List of substrates found:

Dystroglycan  Src  SIT Protein  Paxillin  IGF1-R  Insulin R  LCK  Caveolin-1  DOK3  CDH5  PAG1 


Substrate: Dystroglycan (Adhesion molecule)
Seq-ID: Q14118 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 892 NMTPYRSPPPYVPP        SRC 12795607
LTP
1.00
Csk SH2;
Fyn SH2;
NCK SH2;
Src SH2
DAG1
0.77
- medium

Substrate: Src (Proto-oncogene tyrosine-protein kinase Src)
Seq-ID: P12931 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14765   DDR2_HUMAN
MINT-15459   CAV1_HUMAN
MINT-46002   CTNB1_MOUSE
MINT-50376   RASH_HUMAN
MINT-62340   KPCD_HUMAN
MINT-62342   CDCP1_HUMAN
MINT-65953   DYN1_HUMAN
MINT-65954   DYN2_HUMAN
MINT-68512   PDC6I_HUMAN
MINT-74753   ERBB3_HUMAN
MINT-2792760   PAK2_HUMAN
MINT-2793013   ADA15_HUMAN
MINT-2840132   TLR3_HUMAN
MINT-3381308   FAK1_HUMAN
MINT-3381360   FYN_HUMAN
MINT-4051815   ADRB2_HUMAN
MINT-4961196   AFAD_HUMAN
MINT-4980122   SNIP_MOUSE
MINT-5210599   SNIP_HUMAN
MINT-6539730   CBL_HUMAN
MINT-6771405   FAK1_MOUSE
MINT-6794909   ACTS_HUMAN
MINT-6795322   ACTN1_HUMAN
MINT-6795447   PTN1_HUMAN
MINT-7035260   HNRPK_HUMAN
MINT-7040283   CBLB_HUMAN
MINT-7104422   BCAR1_HUMAN
MINT-7145938   RL10_HUMAN
MINT-7244986   ASAP1_HUMAN
MINT-7244998   FANCA_HUMAN
MINT-7245022   PHAR2_HUMAN
MINT-7245034   ABL1_HUMAN
MINT-7245058   DLGP4_HUMAN
MINT-7245070   SNX17_HUMAN
MINT-7245106   RTN4_HUMAN
MINT-7245118   ASAP2_HUMAN
MINT-7245142   E41L3_HUMAN
MINT-7245154   ICAL_HUMAN
MINT-7245214   FCG2B_HUMAN
MINT-7245226   FCG2C_HUMAN
MINT-7245334   SHAN2_HUMAN
MINT-7245346   SHRM2_HUMAN
MINT-7245358   DNLI3_HUMAN
MINT-7245370   EIF3D_HUMAN
MINT-7245406   HCN2_HUMAN
MINT-7245490   CKAP5_HUMAN
MINT-7245502   M4K1_HUMAN
MINT-7245538   RPP38_HUMAN
MINT-7245562   SP1_HUMAN
MINT-7245574   DOCK1_HUMAN
MINT-7245586   RLGPB_HUMAN
MINT-7245598   ABL2_HUMAN
MINT-7245610   CELR2_HUMAN
MINT-7245622   SOS1_HUMAN
MINT-7245634   AKAP6_HUMAN
MINT-7245670   DPOD1_HUMAN
MINT-7245682   DAG1_HUMAN
MINT-7245694   SNX3_HUMAN
MINT-7245730   KI67_HUMAN
MINT-7245742   CD97_HUMAN
MINT-7245754   RPGF1_HUMAN
MINT-7245778   ACAP1_HUMAN
MINT-7245790   PRIC3_HUMAN
MINT-7245814   AKAP2_HUMAN
MINT-7245826   RRAS_HUMAN
MINT-7296136   P85A_HUMAN
MINT-7296149   ACTB_HUMAN
MINT-7306598   LCP2_HUMAN
MINT-7552515   PTPRA_MOUSE
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
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Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 419 GLARLIEDNEYTARQGAKFPI - 6273838
LTP
1.00
CBL PTB;
Csk SH2;
Src SH2
TyrKc
0.17
1Y57 26.20%
Y 419 GLARLIEDNEYTARQGAKFPI - 11278940
LTP
1.00
CBL PTB;
Csk SH2;
Src SH2
TyrKc
0.17
1Y57 26.20%
Y 419 GLARLIEDNEYTARQGAKFPI SRC 7578094
LTP
1.00
CBL PTB;
Csk SH2;
Src SH2
TyrKc
0.17
1Y57 26.20%
Y 419 GLARLIEDNEYTARQGAKFPI SRC 11804588
LTP
1.00
CBL PTB;
Csk SH2;
Src SH2
TyrKc
0.17
1Y57 26.20%
Y 419 GLARLIEDNEYTARQGAKFPI SRC 15489898
LTP
1.00
CBL PTB;
Csk SH2;
Src SH2
TyrKc
0.17
1Y57 26.20%
Y 419 GLARLIEDNEYTARQGAKFPI - 17081983
HTP
1.00
CBL PTB;
Csk SH2;
Src SH2
TyrKc
0.17
1Y57 26.20%
Y 419 GLARLIEDNEYTARQGAKFPI - 17192257
HTP
1.00
CBL PTB;
Csk SH2;
Src SH2
TyrKc
0.17
1Y57 26.20%
Y 530 EDYFTSTEPQYQPGENL     - 3103926
LTP
0.94
MOD_TYR_CSK
Csk SH2;
Fyn SH2;
Lck SH2;
PIK3R1 SH2;
Src SH2
-
0.46
1FMK 18.34%
Y 530 EDYFTSTEPQYQPGENL     Csk 12468645
LTP
0.94
MOD_TYR_CSK
Csk SH2;
Fyn SH2;
Lck SH2;
PIK3R1 SH2;
Src SH2
-
0.46
1FMK 18.34%
Y 530 EDYFTSTEPQYQPGENL     - 12387813
LTP
0.94
MOD_TYR_CSK
Csk SH2;
Fyn SH2;
Lck SH2;
PIK3R1 SH2;
Src SH2
-
0.46
1FMK 18.34%

Substrate: SIT Protein (Adapter molecule)
Seq-ID: Q9Y3P8 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 169 SQASGPEPELYASVCAQTRRA - 10209036
LTP
- Csk SH2 -
0.66
- medium

Substrate: Paxillin (Cytoskeletal protein; component of focal adhesion.)
Seq-ID: P49023 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 88 HQQPQSSSPVYGSSAKTSSVS SRC 11695992
LTP
0.90
Csk SH2 Paxillin
0.76
- low
Y 88 HQQPQSSSPVYGSSAKTSSVS - 16254239
HTP
0.90
Csk SH2 Paxillin
0.76
- low
Y 88 HQQPQSSSPVYGSSAKTSSVS - 18083107
HTP
0.90
Csk SH2 Paxillin
0.76
- low
Y 118 CSRVGEEEHVYSFPNKQKSAE FAK 7537852
LTP
0.93
CRKL SH2;
CRK SH2;
Csk SH2
Paxillin
0.73
- low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 11774284
LTP
0.93
CRKL SH2;
CRK SH2;
Csk SH2
Paxillin
0.73
- low
Y 118 CSRVGEEEHVYSFPNKQKSAE FAK 7615549
LTP
0.93
CRKL SH2;
CRK SH2;
Csk SH2
Paxillin
0.73
- low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 15592455
HTP
0.93
CRKL SH2;
CRK SH2;
Csk SH2
Paxillin
0.73
- low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 15107421
LTP
0.93
CRKL SH2;
CRK SH2;
Csk SH2
Paxillin
0.73
- low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 16254239
HTP
0.93
CRKL SH2;
CRK SH2;
Csk SH2
Paxillin
0.73
- low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 16094384
HTP
0.93
CRKL SH2;
CRK SH2;
Csk SH2
Paxillin
0.73
- low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 15817476
LTP
0.93
CRKL SH2;
CRK SH2;
Csk SH2
Paxillin
0.73
- low
Y 118 CSRVGEEEHVYSFPNKQKSAE Brk 15572663
LTP
0.93
CRKL SH2;
CRK SH2;
Csk SH2
Paxillin
0.73
- low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 18083107
HTP
0.93
CRKL SH2;
CRK SH2;
Csk SH2
Paxillin
0.73
- low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 18669648
HTP
0.93
CRKL SH2;
CRK SH2;
Csk SH2
Paxillin
0.73
- low

Substrate: IGF1-R (Receptor tyrosine kinase)
Seq-ID: P08069 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 973 NNSRLGNGVLYASVNPEYFSA IGF1R 8550552
LTP
1.00
CRK SH2;
Csk SH2
-
0.16
--
Y 973 NNSRLGNGVLYASVNPEYFSA IGF1R 8940173
LTP
1.00
CRK SH2;
Csk SH2
-
0.16
--
Y 1346 LRASFDERQPYAHMNGGRKNE IGF1R 8550552
LTP
1.00
Csk SH2;
GRB10 SH2;
PIK3R1 SH2;
PTPN11 SH2
-
0.63
--

Substrate: Insulin R (Receptor tyrosine kinase)
Seq-ID: P06213 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1361 FKRSYEEHIPYTHMNGGKKNG INSR 1321605
LTP
0.95
Csk SH2;
GRB10 SH2;
PIK3R1 SH2;
PTPN11 SH2;
SHC1 SH2
-
0.54
--

Substrate: LCK (proto-oncogene tyrosine-protein kinase Lck (from PhosphoBase))
Seq-ID: P06239 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 394 GLARLIEDNEYTAREGAKFPI Lck 3265417
LTP
0.84
Csk SH2 TyrKc
0.18
3LCK 54.59%
Y 394 GLARLIEDNEYTAREGAKFPI - 15592455
HTP
0.84
Csk SH2 TyrKc
0.18
3LCK 54.59%
Y 394 GLARLIEDNEYTAREGAKFPI - 15659558
HTP
0.84
Csk SH2 TyrKc
0.18
3LCK 54.59%
Y 394 GLARLIEDNEYTAREGAKFPI - 17192257
HTP
0.84
Csk SH2 TyrKc
0.18
3LCK 54.59%

Substrate: Caveolin-1 (May act as a scaffolding protein within the caveolar membranes )
Seq-ID: Q03135 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
nitric-oxide synthase binding,
protein complex scaffold,
cholesterol binding,
peptidase activator activity,
receptor binding,
protein binding
lipid particle,
basolateral plasma membrane,
caveola,
perinuclear region of cytoplasm,
apical plasma membrane,
endoplasmic reticulum,
Golgi membrane
cellular response to starvation,
negative regulation of gene-specific transcription from RNA polymerase II promoter,
positive regulation of vasoconstriction,
inactivation of MAPK activity,
maintenance of protein location in cell,
regulation of blood coagulation,
negative regulation of BMP signaling pathway,
cholesterol homeostasis,
positive regulation of calcium ion transport into cytosol,
lipid storage,
mammary gland involution,
positive regulation of peptidyl-serine phosphorylation,
negative regulation of canonical Wnt receptor signaling pathway,
negative regulation of epithelial cell differentiation,
positive regulation of metalloenzyme activity,
negative regulation of peptidyl-serine phosphorylation,
calcium ion transport,
interspecies interaction between organisms,
cytosolic calcium ion homeostasis,
T cell costimulation,
triglyceride metabolic process,
protein homooligomerization,
vesicle organization,
negative regulation of endothelial cell proliferation,
nitric oxide homeostasis,
receptor internalization,
caveola assembly,
regulation of smooth muscle contraction,
membrane depolarization,
regulation of fatty acid metabolic process,
response to hypoxia,
response to estrogen stimulus,
positive regulation of canonical Wnt receptor signaling pathway,
response to progesterone stimulus,
negative regulation of nitric oxide biosynthetic process,
response to calcium ion,
negative regulation of MAPKKK cascade,
negative regulation of protein binding,
vasculogenesis,
skeletal muscle tissue development
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
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Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 14 GKYVDSEGHLYTVPIREQGNI Fyn 12921535
LTP
0.69
Csk SH2 Caveolin
0.29
- low
Y 14 GKYVDSEGHLYTVPIREQGNI SRC 12921535
LTP
0.69
Csk SH2 Caveolin
0.29
- low
Y 14 GKYVDSEGHLYTVPIREQGNI - 14992595
LTP
0.69
Csk SH2 Caveolin
0.29
- low
Y 14 GKYVDSEGHLYTVPIREQGNI - 18083107
HTP
0.69
Csk SH2 Caveolin
0.29
- low

Substrate: DOK3 (Docking proteins interact with receptor tyrosine kinases)
Seq-ID: Q7L591 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
insulin receptor binding plasma membrane,
cytoplasm
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 381 PEPNDLASGLYASVCKRASGP - 16497976
HTP
1.00
Csk SH2;
INPP5D SH2
-
0.58
- medium

Substrate: CDH5
Seq-ID: P33151 [Homo sapiens]
Download:fasta csv
Interaction Network(s):
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 685 RPALDARPSLYAQVQKPPRHA - 18083107
HTP
0.24
Csk SH2;
Src SH2
Cadherin_C
0.61
- medium

Substrate: PAG1
Seq-ID: Q9NWQ8 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 317 TLTEEEISAMYSSVNKPGQLV - 16497976
HTP
1.00
Csk SH2 -
0.73
- medium
Y 317 TLTEEEISAMYSSVNKPGQLV - 18083107
HTP
1.00
Csk SH2 -
0.73
- medium


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