a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

Dystroglycan  Src  SIT Protein  Paxillin  IGF1-R  Insulin R  LCK  Caveolin-1  DOK3  CDH5  PAG1 

Substrate:	Dystroglycan (Adhesion molecule)
Seq-ID:	Q14118 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):	-
External Source(s):
MINT Interaction(s):	[show] MINT-18977   UTRO_HUMAN MINT-7245682   SRC_HUMAN MINT-7247422   FYN_HUMAN MINT-7249366   NCK1_HUMAN MINT-7251982   P85A_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process calcium ion binding, structural constituent of muscle, laminin-1 binding, vinculin binding, actin binding, alpha-actinin binding, tubulin binding filopodium, basement membrane, integral to membrane of membrane fraction, lamellipodium, cytoskeleton, integral to membrane, extracellular space, nucleoplasm, contractile ring negative regulation of MAPKKK cascade, microtubule anchoring, negative regulation of cell migration, cytoskeletal anchoring at plasma membrane, negative regulation of protein kinase B signaling cascade
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	892	NMTPYRSPPPYVPP	SRC	12795607	LTP	1.00		Csk SH2; Fyn SH2; NCK SH2; Src SH2	DAG1	0.77	-	medium

Substrate:	Src (Proto-oncogene tyrosine-protein kinase Src)
Seq-ID:	P12931 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-14765   DDR2_HUMAN MINT-15459   CAV1_HUMAN MINT-46002   CTNB1_MOUSE MINT-50376   RASH_HUMAN MINT-62340   KPCD_HUMAN MINT-62342   CDCP1_HUMAN MINT-65953   DYN1_HUMAN MINT-65954   DYN2_HUMAN MINT-68512   PDC6I_HUMAN MINT-74753   ERBB3_HUMAN MINT-2792760   PAK2_HUMAN MINT-2793013   ADA15_HUMAN MINT-2840132   TLR3_HUMAN MINT-3381308   FAK1_HUMAN MINT-3381360   FYN_HUMAN MINT-4051815   ADRB2_HUMAN MINT-4961196   AFAD_HUMAN MINT-4980122   SNIP_MOUSE MINT-5210599   SNIP_HUMAN MINT-6539730   CBL_HUMAN MINT-6771405   FAK1_MOUSE MINT-6794909   ACTS_HUMAN MINT-6795322   ACTN1_HUMAN MINT-6795447   PTN1_HUMAN MINT-7035260   HNRPK_HUMAN MINT-7040283   CBLB_HUMAN MINT-7104422   BCAR1_HUMAN MINT-7145938   RL10_HUMAN MINT-7244986   ASAP1_HUMAN MINT-7244998   FANCA_HUMAN MINT-7245022   PHAR2_HUMAN MINT-7245034   ABL1_HUMAN MINT-7245058   DLGP4_HUMAN MINT-7245070   SNX17_HUMAN MINT-7245106   RTN4_HUMAN MINT-7245118   ASAP2_HUMAN MINT-7245142   E41L3_HUMAN MINT-7245154   ICAL_HUMAN MINT-7245214   FCG2B_HUMAN MINT-7245226   FCG2C_HUMAN MINT-7245334   SHAN2_HUMAN MINT-7245346   SHRM2_HUMAN MINT-7245358   DNLI3_HUMAN MINT-7245370   EIF3D_HUMAN MINT-7245406   HCN2_HUMAN MINT-7245490   CKAP5_HUMAN MINT-7245502   M4K1_HUMAN MINT-7245538   RPP38_HUMAN MINT-7245562   SP1_HUMAN MINT-7245574   DOCK1_HUMAN MINT-7245586   RLGPB_HUMAN MINT-7245598   ABL2_HUMAN MINT-7245610   CELR2_HUMAN MINT-7245622   SOS1_HUMAN MINT-7245634   AKAP6_HUMAN MINT-7245670   DPOD1_HUMAN MINT-7245682   DAG1_HUMAN MINT-7245694   SNX3_HUMAN MINT-7245730   KI67_HUMAN MINT-7245742   CD97_HUMAN MINT-7245754   RPGF1_HUMAN MINT-7245778   ACAP1_HUMAN MINT-7245790   PRIC3_HUMAN MINT-7245814   AKAP2_HUMAN MINT-7245826   RRAS_HUMAN MINT-7296136   P85A_HUMAN MINT-7296149   ACTB_HUMAN MINT-7306598   LCP2_HUMAN MINT-7552515   PTPRA_MOUSE
GO-Terms:	[show] Molecular Function Cellular Component Biological Process SH3/SH2 adaptor activity, non-membrane spanning protein tyrosine kinase activity, ATP binding, integrin binding, SH2 domain binding caveola, cytosol protein amino acid phosphorylation, regulation of bone resorption, signal complex assembly, regulation of vascular permeability, response to interleukin-1, interspecies interaction between organisms, Ras protein signal transduction, positive regulation of integrin activation, intracellular protein kinase cascade
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	419	GLARLIEDNEYTARQGAKFPI	-	6273838	LTP	1.00		CBL PTB; Csk SH2; Src SH2	TyrKc	0.17	1Y57	26.20%
Y	419	GLARLIEDNEYTARQGAKFPI	-	11278940	LTP	1.00		CBL PTB; Csk SH2; Src SH2	TyrKc	0.17	1Y57	26.20%
Y	419	GLARLIEDNEYTARQGAKFPI	SRC	7578094	LTP	1.00		CBL PTB; Csk SH2; Src SH2	TyrKc	0.17	1Y57	26.20%
Y	419	GLARLIEDNEYTARQGAKFPI	SRC	11804588	LTP	1.00		CBL PTB; Csk SH2; Src SH2	TyrKc	0.17	1Y57	26.20%
Y	419	GLARLIEDNEYTARQGAKFPI	SRC	15489898	LTP	1.00		CBL PTB; Csk SH2; Src SH2	TyrKc	0.17	1Y57	26.20%
Y	419	GLARLIEDNEYTARQGAKFPI	-	17081983	HTP	1.00		CBL PTB; Csk SH2; Src SH2	TyrKc	0.17	1Y57	26.20%
Y	419	GLARLIEDNEYTARQGAKFPI	-	17192257	HTP	1.00		CBL PTB; Csk SH2; Src SH2	TyrKc	0.17	1Y57	26.20%
Y	530	EDYFTSTEPQYQPGENL	-	3103926	LTP	0.94	MOD_TYR_CSK	Csk SH2; Fyn SH2; Lck SH2; PIK3R1 SH2; Src SH2	-	0.46	1FMK	18.34%
Y	530	EDYFTSTEPQYQPGENL	Csk	12468645	LTP	0.94	MOD_TYR_CSK	Csk SH2; Fyn SH2; Lck SH2; PIK3R1 SH2; Src SH2	-	0.46	1FMK	18.34%
Y	530	EDYFTSTEPQYQPGENL	-	12387813	LTP	0.94	MOD_TYR_CSK	Csk SH2; Fyn SH2; Lck SH2; PIK3R1 SH2; Src SH2	-	0.46	1FMK	18.34%

Substrate:	SIT Protein (Adapter molecule)
Seq-ID:	Q9Y3P8 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process kinase binding, SH2 domain binding integral to plasma membrane signal transduction, regulation of T cell activation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	169	SQASGPEPELYASVCAQTRRA	-	10209036	LTP	-		Csk SH2	-	0.66	-	medium

Substrate:	Paxillin (Cytoskeletal protein; component of focal adhesion.)
Seq-ID:	P49023 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-1953339   GIT1_HUMAN MINT-1953360   GIT2_HUMAN MINT-6169431   CSK_HUMAN MINT-6169440   PTN11_HUMAN MINT-6169502   GAB1_HUMAN MINT-6763928   CRK_HUMAN MINT-7145479   ASAP1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process beta-catenin binding, vinculin binding, zinc ion binding focal adhesion, cytoplasm, microtubule associated complex, lamellipodium muscle contraction, signal complex assembly, signal transduction, cell-matrix adhesion, cellular response to reactive oxygen species
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	88	HQQPQSSSPVYGSSAKTSSVS	SRC	11695992	LTP	0.90		Csk SH2	Paxillin	0.76	-	low
Y	88	HQQPQSSSPVYGSSAKTSSVS	-	16254239	HTP	0.90		Csk SH2	Paxillin	0.76	-	low
Y	88	HQQPQSSSPVYGSSAKTSSVS	-	18083107	HTP	0.90		Csk SH2	Paxillin	0.76	-	low
Y	118	CSRVGEEEHVYSFPNKQKSAE	FAK	7537852	LTP	0.93		CRKL SH2; CRK SH2; Csk SH2	Paxillin	0.73	-	low
Y	118	CSRVGEEEHVYSFPNKQKSAE	-	11774284	LTP	0.93		CRKL SH2; CRK SH2; Csk SH2	Paxillin	0.73	-	low
Y	118	CSRVGEEEHVYSFPNKQKSAE	FAK	7615549	LTP	0.93		CRKL SH2; CRK SH2; Csk SH2	Paxillin	0.73	-	low
Y	118	CSRVGEEEHVYSFPNKQKSAE	-	15592455	HTP	0.93		CRKL SH2; CRK SH2; Csk SH2	Paxillin	0.73	-	low
Y	118	CSRVGEEEHVYSFPNKQKSAE	-	15107421	LTP	0.93		CRKL SH2; CRK SH2; Csk SH2	Paxillin	0.73	-	low
Y	118	CSRVGEEEHVYSFPNKQKSAE	-	16254239	HTP	0.93		CRKL SH2; CRK SH2; Csk SH2	Paxillin	0.73	-	low
Y	118	CSRVGEEEHVYSFPNKQKSAE	-	16094384	HTP	0.93		CRKL SH2; CRK SH2; Csk SH2	Paxillin	0.73	-	low
Y	118	CSRVGEEEHVYSFPNKQKSAE	-	15817476	LTP	0.93		CRKL SH2; CRK SH2; Csk SH2	Paxillin	0.73	-	low
Y	118	CSRVGEEEHVYSFPNKQKSAE	Brk	15572663	LTP	0.93		CRKL SH2; CRK SH2; Csk SH2	Paxillin	0.73	-	low
Y	118	CSRVGEEEHVYSFPNKQKSAE	-	18083107	HTP	0.93		CRKL SH2; CRK SH2; Csk SH2	Paxillin	0.73	-	low
Y	118	CSRVGEEEHVYSFPNKQKSAE	-	18669648	HTP	0.93		CRKL SH2; CRK SH2; Csk SH2	Paxillin	0.73	-	low

Substrate:	IGF1-R (Receptor tyrosine kinase)
Seq-ID:	P08069 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-15644   GRB10_HUMAN MINT-18053   IRS2_HUMAN MINT-1774754   ARHGC_MOUSE MINT-1774976   ARHGC_HUMAN MINT-6800783   PTN1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process phosphoinositide 3-kinase binding, identical protein binding, insulin-like growth factor receptor activity, insulin binding, metal ion binding, insulin receptor binding, insulin receptor substrate binding, ATP binding, insulin-like growth factor I binding microsome, integral to plasma membrane positive regulation of DNA replication, positive regulation of cell proliferation, positive regulation of cell migration, anti-apoptosis, phosphoinositide 3-kinase cascade, phosphoinositide-mediated signaling, immune response, protein amino acid autophosphorylation, insulin receptor signaling pathway, protein tetramerization
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	973	NNSRLGNGVLYASVNPEYFSA	IGF1R	8550552	LTP	1.00		CRK SH2; Csk SH2	-	0.16	-	-
Y	973	NNSRLGNGVLYASVNPEYFSA	IGF1R	8940173	LTP	1.00		CRK SH2; Csk SH2	-	0.16	-	-
Y	1346	LRASFDERQPYAHMNGGRKNE	IGF1R	8550552	LTP	1.00		Csk SH2; GRB10 SH2; PIK3R1 SH2; PTPN11 SH2	-	0.63	-	-

Substrate:	Insulin R (Receptor tyrosine kinase)
Seq-ID:	P06213 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-16516   GRB10_HUMAN MINT-16842   MD2L1_HUMAN MINT-18199   IRS2_HUMAN MINT-19010   IRS1_HUMAN MINT-73466   GRB10_MOUSE MINT-6793537   INSR_RAT MINT-6794075   IRS1_MOUSE MINT-6794090   INSR_MOUSE MINT-6794946   PTN1_HUMAN MINT-6795115   IRS1_RAT
GO-Terms:	[show] Molecular Function Cellular Component Biological Process insulin-like growth factor receptor binding, insulin binding, PTB domain binding, GTP binding, metal ion binding, insulin receptor substrate binding, ATP binding, insulin-like growth factor I binding, insulin receptor activity, SH2 domain binding, phosphoinositide 3-kinase binding, insulin-like growth factor II binding, receptor signaling protein tyrosine kinase activity microsome, caveola, insulin receptor complex, endosome membrane positive regulation of glycolysis, positive regulation of MAPKKK cascade, positive regulation of developmental growth, regulation of embryonic development, heart morphogenesis, positive regulation of cell migration, carbohydrate metabolic process, protein heterotetramerization, positive regulation of protein kinase B signaling cascade, protein amino acid autophosphorylation, activation of MAPK activity, positive regulation of glycogen biosynthetic process, positive regulation of mitosis, peptidyl-tyrosine phosphorylation, positive regulation of glucose import, positive regulation of respiratory burst, activation of protein kinase B activity, G-protein coupled receptor protein signaling pathway, positive regulation of DNA replication, positive regulation of protein amino acid phosphorylation, positive regulation of cell proliferation, glucose homeostasis, positive regulation of nitric oxide biosynthetic process, transformation of host cell by virus, regulation of gene-specific transcription
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1361	FKRSYEEHIPYTHMNGGKKNG	INSR	1321605	LTP	0.95		Csk SH2; GRB10 SH2; PIK3R1 SH2; PTPN11 SH2; SHC1 SH2	-	0.54	-	-

Substrate:	LCK (proto-oncogene tyrosine-protein kinase Lck (from PhosphoBase))
Seq-ID:	P06239 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-15516   CBL_HUMAN MINT-56730   KSYK_HUMAN MINT-59474   LCP2_HUMAN MINT-59476   ZAP70_HUMAN MINT-60779   MK01_HUMAN MINT-60782   CD3Z_HUMAN MINT-61276   G3BP1_HUMAN MINT-66002   CD4_HUMAN MINT-66003   P85A_HUMAN MINT-68489   DLG1_HUMAN MINT-3373863   HS90A_HUMAN MINT-3373920   GCR_HUMAN MINT-7135817   SH22A_HUMAN MINT-7212471   KHDR1_HUMAN MINT-7212499   WASP_HUMAN MINT-7218109   ADA15_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process phosphoinositide 3-kinase binding, protein C-terminus binding, protein kinase binding, protein serine/threonine phosphatase activity, glycoprotein binding, non-membrane spanning protein tyrosine kinase activity, ATP binding, CD8 receptor binding, ATPase binding, CD4 receptor binding, SH2 domain binding plasma membrane, cytosol, Golgi apparatus, membrane raft, pericentriolar material protein amino acid phosphorylation, T cell differentiation, response to drug, activation of caspase activity, positive regulation of T cell activation, positive regulation of T cell receptor signaling pathway, release of sequestered calcium ion into cytosol, interspecies interaction between organisms, cellular zinc ion homeostasis, induction of apoptosis
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	394	GLARLIEDNEYTAREGAKFPI	Lck	3265417	LTP	0.84		Csk SH2	TyrKc	0.18	3LCK	54.59%
Y	394	GLARLIEDNEYTAREGAKFPI	-	15592455	HTP	0.84		Csk SH2	TyrKc	0.18	3LCK	54.59%
Y	394	GLARLIEDNEYTAREGAKFPI	-	15659558	HTP	0.84		Csk SH2	TyrKc	0.18	3LCK	54.59%
Y	394	GLARLIEDNEYTAREGAKFPI	-	17192257	HTP	0.84		Csk SH2	TyrKc	0.18	3LCK	54.59%

Substrate:	Caveolin-1 (May act as a scaffolding protein within the caveolar membranes )
Seq-ID:	Q03135 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-14113   RASH_HUMAN MINT-15459   SRC_HUMAN MINT-50920   MDR1_HUMAN MINT-6764866   PTN1_HUMAN MINT-6793815   PTN6_HUMAN MINT-6793823   PTEN_HUMAN MINT-6793881   PTN11_HUMAN MINT-7234712   SDPR_HUMAN MINT-7234742   PRDBP_HUMAN MINT-7307629   TRXR1_HUMAN MINT-7309906   SCRB2_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process nitric-oxide synthase binding, protein complex scaffold, cholesterol binding, peptidase activator activity, receptor binding, protein binding lipid particle, basolateral plasma membrane, caveola, perinuclear region of cytoplasm, apical plasma membrane, endoplasmic reticulum, Golgi membrane cellular response to starvation, negative regulation of gene-specific transcription from RNA polymerase II promoter, positive regulation of vasoconstriction, inactivation of MAPK activity, maintenance of protein location in cell, regulation of blood coagulation, negative regulation of BMP signaling pathway, cholesterol homeostasis, positive regulation of calcium ion transport into cytosol, lipid storage, mammary gland involution, positive regulation of peptidyl-serine phosphorylation, negative regulation of canonical Wnt receptor signaling pathway, negative regulation of epithelial cell differentiation, positive regulation of metalloenzyme activity, negative regulation of peptidyl-serine phosphorylation, calcium ion transport, interspecies interaction between organisms, cytosolic calcium ion homeostasis, T cell costimulation, triglyceride metabolic process, protein homooligomerization, vesicle organization, negative regulation of endothelial cell proliferation, nitric oxide homeostasis, receptor internalization, caveola assembly, regulation of smooth muscle contraction, membrane depolarization, regulation of fatty acid metabolic process, response to hypoxia, response to estrogen stimulus, positive regulation of canonical Wnt receptor signaling pathway, response to progesterone stimulus, negative regulation of nitric oxide biosynthetic process, response to calcium ion, negative regulation of MAPKKK cascade, negative regulation of protein binding, vasculogenesis, skeletal muscle tissue development
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	14	GKYVDSEGHLYTVPIREQGNI	Fyn	12921535	LTP	0.69		Csk SH2	Caveolin	0.29	-	low
Y	14	GKYVDSEGHLYTVPIREQGNI	SRC	12921535	LTP	0.69		Csk SH2	Caveolin	0.29	-	low
Y	14	GKYVDSEGHLYTVPIREQGNI	-	14992595	LTP	0.69		Csk SH2	Caveolin	0.29	-	low
Y	14	GKYVDSEGHLYTVPIREQGNI	-	18083107	HTP	0.69		Csk SH2	Caveolin	0.29	-	low

Substrate:	DOK3 (Docking proteins interact with receptor tyrosine kinases)
Seq-ID:	Q7L591 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	MINT-4329711   SHIP1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process insulin receptor binding plasma membrane, cytoplasm
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	381	PEPNDLASGLYASVCKRASGP	-	16497976	HTP	1.00		Csk SH2; INPP5D SH2	-	0.58	-	medium

Substrate:	CDH5
Seq-ID:	P33151 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-49634   VGFR2_HUMAN MINT-49636   SHC1_HUMAN MINT-4085197   PARD3_HUMAN MINT-4085223   CTNB1_HUMAN MINT-4085515   PAR6A_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process calcium ion binding, beta-catenin binding, receptor binding membrane fraction, integral to membrane homophilic cell adhesion
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	685	RPALDARPSLYAQVQKPPRHA	-	18083107	HTP	0.24		Csk SH2; Src SH2	Cadherin_C	0.61	-	medium

Substrate:	PAG1
Seq-ID:	Q9NWQ8 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	MINT-19912   NHRF1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process SH3/SH2 adaptor activity, SH2 domain binding plasma membrane, integral to membrane, membrane raft intracellular signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	317	TLTEEEISAMYSSVNKPGQLV	-	16497976	HTP	1.00		Csk SH2	-	0.73	-	medium
Y	317	TLTEEEISAMYSSVNKPGQLV	-	18083107	HTP	1.00		Csk SH2	-	0.73	-	medium