Substrate: IL-4R alpha (Cytokin receptor)
Seq-ID: P24394 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
MINT-63292   ARI2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor signaling protein activity,
interleukin-4 receptor activity		 extracellular region,
integral to plasma membrane		 immune response
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 497 TPLVIAGNPAYRSFSNSLSQS - 9545332
LTP
1.00
 FRS2 PTB;
IRS1 PTB;
SHC1 SH2		 -
0.47
 - medium
Y 497 TPLVIAGNPAYRSFSNSLSQS - 9697832
LTP
1.00
 FRS2 PTB;
IRS1 PTB;
SHC1 SH2		 -
0.47
 - medium

Substrate: TRKA (Required for high affinity binding to nerve growth factor , neurotrophin-3 and neurotrophin-4/5r.)
Seq-ID: P04629 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
MINT-6793941   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transmembrane receptor protein tyrosine kinase activity,
neurotrophin receptor activity,
ATP binding		 endosome,
integral to plasma membrane		 activation of adenylate cyclase activity,
Ras protein signal transduction,
transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 496 LQGHIIENPQYFSDACVHHIK TRKA 11159935
LTP
1.00
 FRS2 PTB;
GRB2 SH2;
PLCG1 SH2;
SHC1 PTB;
SHC1 SH2		 -
0.16
 - medium
Y 496 LQGHIIENPQYFSDACVHHIK TRKA 8155326
LTP
1.00
 FRS2 PTB;
GRB2 SH2;
PLCG1 SH2;
SHC1 PTB;
SHC1 SH2		 -
0.16
 - medium

Substrate: RET (Probable receptor with tyrosine-protein kinase activity; important for development.)
Seq-ID: P07949 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-60970   CBL_HUMAN
MINT-60975   GRB2_HUMAN
MINT-60981   SHC1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
calcium ion binding,
transmembrane receptor protein tyrosine kinase activity,
ATP binding		 integral to membrane protein amino acid phosphorylation,
posterior midgut development,
homophilic cell adhesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1062 LPSTWIENKLYGMSDPNWPGE - 11470823
LTP
0.19
 FRS2 PTB;
IRS1 PTB;
PIK3R1 SH2;
SHC1 PTB;
SHC1 SH2;
SHC3 PTB;
SHC3 SH2		 -
0.43
 --
Y 1062 LPSTWIENKLYGMSDPNWPGE RET 14711813
LTP
0.19
 FRS2 PTB;
IRS1 PTB;
PIK3R1 SH2;
SHC1 PTB;
SHC1 SH2;
SHC3 PTB;
SHC3 SH2		 -
0.43
 --
Y 1062 LPSTWIENKLYGMSDPNWPGE RET 14981541
LTP
0.19
 FRS2 PTB;
IRS1 PTB;
PIK3R1 SH2;
SHC1 PTB;
SHC1 SH2;
SHC3 PTB;
SHC3 SH2		 -
0.43
 --

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