List of substrates found:

CD31  CD95 antigen  Shc  Epo-R  CD150  DOK3  IL-4R alpha  FCGR2B  c-met  p62DOK 


Substrate: CD31 (Adhesion molecule)
Seq-ID: P16284 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 690 NKEPLNSDVQYTEVQVSSAES - 15201144
LTP
1.00
INPP5D SH2;
PLCG1 SH2;
PTPN11 SH2;
PTPN6 SH2;
Src SH2
-
0.58
- medium

Substrate: CD95 antigen (Cell surface receptor)
Seq-ID: P25445 [Homo sapiens]
Download:fasta csv
Interaction Network(s):
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 291 WHQLHGKKEAYDTLIKDLKKA - 17195092
LTP
0.97
Fyn SH2;
INPP5D SH2
DEATH
0.33
3EZQ 62.45%
Y 291 WHQLHGKKEAYDTLIKDLKKA - 15660394
LTP
0.97
Fyn SH2;
INPP5D SH2
DEATH
0.33
3EZQ 62.45%

Substrate: Shc ( Adaptor molecule)
Seq-ID: P29353 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
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Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 349 EEEEEPPDHQYYNDFPGKEPP - 11075717
LTP
1.00
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.86
--
Y 349 EEEEEPPDHQYYNDFPGKEPP - 9121430
LTP
1.00
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.86
--
Y 349 EEEEEPPDHQYYNDFPGKEPP SYK 9710204
LTP
1.00
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.86
--
Y 349 EEEEEPPDHQYYNDFPGKEPP ZAP70 9710204
LTP
1.00
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.86
--
Y 349 EEEEEPPDHQYYNDFPGKEPP - 10891441
LTP
1.00
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.86
--
Y 349 EEEEEPPDHQYYNDFPGKEPP - 11687594
LTP
1.00
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.86
--
Y 349 EEEEEPPDHQYYNDFPGKEPP - 15592455
HTP
1.00
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.86
--
Y 349 EEEEEPPDHQYYNDFPGKEPP FLT4 9927207
LTP
1.00
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.86
--
Y 350 EEEEPPDHQYYNDFPGKEPPL - 11075717
LTP
1.00
GRB2 SH2;
INPP5D SH2
-
0.85
--
Y 350 EEEEPPDHQYYNDFPGKEPPL - 9121430
LTP
1.00
GRB2 SH2;
INPP5D SH2
-
0.85
--
Y 350 EEEEPPDHQYYNDFPGKEPPL SYK 9710204
LTP
1.00
GRB2 SH2;
INPP5D SH2
-
0.85
--
Y 350 EEEEPPDHQYYNDFPGKEPPL ZAP70 9710204
LTP
1.00
GRB2 SH2;
INPP5D SH2
-
0.85
--
Y 350 EEEEPPDHQYYNDFPGKEPPL - 15592455
HTP
1.00
GRB2 SH2;
INPP5D SH2
-
0.85
--
Y 350 EEEEPPDHQYYNDFPGKEPPL FLT4 9927207
LTP
1.00
GRB2 SH2;
INPP5D SH2
-
0.85
--
Y 427 PGRELFDDPSYVNVQNLDKAR - 11075717
LTP
0.99
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.62
--
Y 427 PGRELFDDPSYVNVQNLDKAR SYK 9710204
LTP
0.99
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.62
--
Y 427 PGRELFDDPSYVNVQNLDKAR ZAP70 9710204
LTP
0.99
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.62
--
Y 427 PGRELFDDPSYVNVQNLDKAR - 8610109
LTP
0.99
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.62
--
Y 427 PGRELFDDPSYVNVQNLDKAR - 9741627
LTP
0.99
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.62
--
Y 427 PGRELFDDPSYVNVQNLDKAR - 12522270
HTP
0.99
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.62
--
Y 427 PGRELFDDPSYVNVQNLDKAR - 15592455
HTP
0.99
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.62
--
Y 427 PGRELFDDPSYVNVQNLDKAR FLT4 9927207
LTP
0.99
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.62
--
Y 427 PGRELFDDPSYVNVQNLDKAR - 18083107
HTP
0.99
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.62
--
Y 427 PGRELFDDPSYVNVQNLDKAR - 18669648
HTP
0.99
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.62
--

Substrate: Epo-R (Receptor for erythropoietin, a major activator of erythropoiesis)
Seq-ID: P19235 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
erythropoietin receptor activity extracellular region,
integral to plasma membrane
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 368 PVGSEHAQDTYLVLDKWLLPR Lyn 10579919
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
STAT5 SH2;
SYK SH2
-
0.32
- low
Y 368 PVGSEHAQDTYLVLDKWLLPR JAK2 10579919
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
STAT5 SH2;
SYK SH2
-
0.32
- low
Y 426 PEGASAASFEYTILDPSSQLL - 10579919
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2
-
0.45
- low
Y 426 PEGASAASFEYTILDPSSQLL - 12027890
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2
-
0.45
- low
Y 426 PEGASAASFEYTILDPSSQLL - 12441334
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2
-
0.45
- low
Y 426 PEGASAASFEYTILDPSSQLL - 10660611
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2
-
0.45
- low
Y 456 PPTPPHLKYLYLVVSDSGIST - 10579919
LTP
1.00
CISH SH2;
CRKL SH2;
INPP5D SH2;
PLCG2 SH2;
SOCS3 SH2;
STAT5 SH2
-
0.36
- low
Y 456 PPTPPHLKYLYLVVSDSGIST - 11443118
LTP
1.00
CISH SH2;
CRKL SH2;
INPP5D SH2;
PLCG2 SH2;
SOCS3 SH2;
STAT5 SH2
-
0.36
- low
Y 456 PPTPPHLKYLYLVVSDSGIST - 12027890
LTP
1.00
CISH SH2;
CRKL SH2;
INPP5D SH2;
PLCG2 SH2;
SOCS3 SH2;
STAT5 SH2
-
0.36
- low
Y 504 IPAAEPLPPSYVACS       - 10579919
LTP
0.67
INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PLCG2 SH2;
STAT5 SH2
-
0.34
- low
Y 504 IPAAEPLPPSYVACS       - 7559499
LTP
0.67
INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PLCG2 SH2;
STAT5 SH2
-
0.34
- low
Y 504 IPAAEPLPPSYVACS       - 9573010
LTP
0.67
INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PLCG2 SH2;
STAT5 SH2
-
0.34
- low

Substrate: CD150 (T cell antigen receptor)
Seq-ID: Q13291 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 281 TTVEKKSLTIYAQVQKPGPLQ Fyn 11806999
LTP
1.00
FGR SH2;
INPP5D SH2;
PTPN11 SH2;
SH2D1A SH2;
SH2D1B SH2
-
0.39
- low
Y 281 TTVEKKSLTIYAQVQKPGPLQ - 18083107
HTP
1.00
FGR SH2;
INPP5D SH2;
PTPN11 SH2;
SH2D1A SH2;
SH2D1B SH2
-
0.39
- low
Y 307 FPAQDPCTTIYVAATEPVPES Fyn 11806999
LTP
1.00
INPP5D SH2;
PTPN11 SH2;
SH2D1A SH2;
SH2D1B SH2
-
0.40
- low
Y 307 FPAQDPCTTIYVAATEPVPES Lck 11806999
LTP
1.00
INPP5D SH2;
PTPN11 SH2;
SH2D1A SH2;
SH2D1B SH2
-
0.40
- low
Y 327 SVQETNSITVYASVTLPES   Fyn 11806999
LTP
1.00
FGR SH2;
INPP5D SH2;
PTPN11 SH2;
SH2D1A SH2;
SH2D1B SH2
-
0.38
- low
Y 327 SVQETNSITVYASVTLPES   Lyn 15315965
LTP
1.00
FGR SH2;
INPP5D SH2;
PTPN11 SH2;
SH2D1A SH2;
SH2D1B SH2
-
0.38
- low

Substrate: DOK3 (Docking proteins interact with receptor tyrosine kinases)
Seq-ID: Q7L591 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
insulin receptor binding plasma membrane,
cytoplasm
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 381 PEPNDLASGLYASVCKRASGP - 16497976
HTP
1.00
Csk SH2;
INPP5D SH2
-
0.58
- medium

Substrate: IL-4R alpha (Cytokin receptor)
Seq-ID: P24394 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 713 LVDSLGSGIVYSALTCHLCGH - 9670964
LTP
1.00
INPP5D SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2
-
0.17
- medium

Substrate: FCGR2B (protein binding)
Seq-ID: P31994 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 292 DKVGAENTITYSLLMHPDALE Lyn 8756631
LTP
1.00
INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2
-
0.42
- low
Y 292 DKVGAENTITYSLLMHPDALE BLK 8756631
LTP
1.00
INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2
-
0.42
- low

Substrate: c-met (Receptor tyrosine kinase for hepatocyte growth factor.)
Seq-ID: P08581 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
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Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1356 GEHYVHVNATYVNVKCVAPYP - 12475979
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 9444958
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 9252406
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 7513258
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP Met 7731718
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 8662889
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP Met 7961992
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP Met 7687741
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 9826708
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%

Substrate: p62DOK (Docking protein, common target of PTKs)
Seq-ID: Q99704 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 203 QILEPLLSWPYTLLRRYGRDK - 12087092
LTP
1.00
CRKL SH2;
INPP5D SH2
PTBI
0.17
2V76 5.24%
Y 362 KLTDPKEDPIYDEPEGLAPVP - 12087092
LTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2
-
0.82
--
Y 362 KLTDPKEDPIYDEPEGLAPVP INSR 11551902
LTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2
-
0.82
--
Y 362 KLTDPKEDPIYDEPEGLAPVP - 10688886
LTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2
-
0.82
--
Y 362 KLTDPKEDPIYDEPEGLAPVP - 15592455
HTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2
-
0.82
--
Y 362 KLTDPKEDPIYDEPEGLAPVP - 16094384
HTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2
-
0.82
--
Y 377 GLAPVPPQGLYDLPREPKDAW - 12087092
LTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
RASA_group SH2
-
0.62
--
Y 377 GLAPVPPQGLYDLPREPKDAW - 10688886
LTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
RASA_group SH2
-
0.62
--
Y 377 GLAPVPPQGLYDLPREPKDAW - 15592455
HTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
RASA_group SH2
-
0.62
--
Y 377 GLAPVPPQGLYDLPREPKDAW - 16094384
HTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
RASA_group SH2
-
0.62
--


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