List of substrates found:

CD31  CD95 antigen  Shc  Epo-R  CD150  DOK3  IL-4R alpha  FCGR2B  c-met  p62DOK 


Substrate: CD31 (Adhesion molecule)
Seq-ID: P16284 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 690 NKEPLNSDVQYTEVQVSSAES - 15201144
LTP
1.00
INPP5D SH2;
PLCG1 SH2;
PTPN11 SH2;
PTPN6 SH2;
Src SH2
-
0.58
- medium

Substrate: CD95 antigen (Cell surface receptor)
Seq-ID: P25445 [Homo sapiens]
Download:fasta csv
Interaction Network(s):
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 291 WHQLHGKKEAYDTLIKDLKKA - 17195092
LTP
0.97
Fyn SH2;
INPP5D SH2
DEATH
0.33
3EZQ 62.45%
Y 291 WHQLHGKKEAYDTLIKDLKKA - 15660394
LTP
0.97
Fyn SH2;
INPP5D SH2
DEATH
0.33
3EZQ 62.45%

Substrate: Shc ( Adaptor molecule)
Seq-ID: P29353 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 349 EEEEEPPDHQYYNDFPGKEPP - 11075717
LTP
1.00
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.86
--
Y 349 EEEEEPPDHQYYNDFPGKEPP - 9121430
LTP
1.00
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.86
--
Y 349 EEEEEPPDHQYYNDFPGKEPP SYK 9710204
LTP
1.00
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.86
--
Y 349 EEEEEPPDHQYYNDFPGKEPP ZAP70 9710204
LTP
1.00
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.86
--
Y 349 EEEEEPPDHQYYNDFPGKEPP - 10891441
LTP
1.00
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.86
--
Y 349 EEEEEPPDHQYYNDFPGKEPP - 11687594
LTP
1.00
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.86
--
Y 349 EEEEEPPDHQYYNDFPGKEPP - 15592455
HTP
1.00
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.86
--
Y 349 EEEEEPPDHQYYNDFPGKEPP FLT4 9927207
LTP
1.00
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.86
--
Y 350 EEEEPPDHQYYNDFPGKEPPL - 11075717
LTP
1.00
GRB2 SH2;
INPP5D SH2
-
0.85
--
Y 350 EEEEPPDHQYYNDFPGKEPPL - 9121430
LTP
1.00
GRB2 SH2;
INPP5D SH2
-
0.85
--
Y 350 EEEEPPDHQYYNDFPGKEPPL SYK 9710204
LTP
1.00
GRB2 SH2;
INPP5D SH2
-
0.85
--
Y 350 EEEEPPDHQYYNDFPGKEPPL ZAP70 9710204
LTP
1.00
GRB2 SH2;
INPP5D SH2
-
0.85
--
Y 350 EEEEPPDHQYYNDFPGKEPPL - 15592455
HTP
1.00
GRB2 SH2;
INPP5D SH2
-
0.85
--
Y 350 EEEEPPDHQYYNDFPGKEPPL FLT4 9927207
LTP
1.00
GRB2 SH2;
INPP5D SH2
-
0.85
--
Y 427 PGRELFDDPSYVNVQNLDKAR - 11075717
LTP
0.99
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.62
--
Y 427 PGRELFDDPSYVNVQNLDKAR SYK 9710204
LTP
0.99
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.62
--
Y 427 PGRELFDDPSYVNVQNLDKAR ZAP70 9710204
LTP
0.99
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.62
--
Y 427 PGRELFDDPSYVNVQNLDKAR - 8610109
LTP
0.99
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.62
--
Y 427 PGRELFDDPSYVNVQNLDKAR - 9741627
LTP
0.99
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.62
--
Y 427 PGRELFDDPSYVNVQNLDKAR - 12522270
HTP
0.99
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.62
--
Y 427 PGRELFDDPSYVNVQNLDKAR - 15592455
HTP
0.99
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.62
--
Y 427 PGRELFDDPSYVNVQNLDKAR FLT4 9927207
LTP
0.99
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.62
--
Y 427 PGRELFDDPSYVNVQNLDKAR - 18083107
HTP
0.99
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.62
--
Y 427 PGRELFDDPSYVNVQNLDKAR - 18669648
HTP
0.99
GRAP2 SH2;
GRB2 SH2;
INPP5D SH2
-
0.62
--

Substrate: Epo-R (Receptor for erythropoietin, a major activator of erythropoiesis)
Seq-ID: P19235 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
erythropoietin receptor activity extracellular region,
integral to plasma membrane
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 368 PVGSEHAQDTYLVLDKWLLPR Lyn 10579919
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
STAT5 SH2;
SYK SH2
-
0.32
- low
Y 368 PVGSEHAQDTYLVLDKWLLPR JAK2 10579919
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
STAT5 SH2;
SYK SH2
-
0.32
- low
Y 426 PEGASAASFEYTILDPSSQLL - 10579919
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2
-
0.45
- low
Y 426 PEGASAASFEYTILDPSSQLL - 12027890
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2
-
0.45
- low
Y 426 PEGASAASFEYTILDPSSQLL - 12441334
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2
-
0.45
- low
Y 426 PEGASAASFEYTILDPSSQLL - 10660611
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2
-
0.45
- low
Y 456 PPTPPHLKYLYLVVSDSGIST - 10579919
LTP
1.00
CISH SH2;
CRKL SH2;
INPP5D SH2;
PLCG2 SH2;
SOCS3 SH2;
STAT5 SH2
-
0.36
- low
Y 456 PPTPPHLKYLYLVVSDSGIST - 11443118
LTP
1.00
CISH SH2;
CRKL SH2;
INPP5D SH2;
PLCG2 SH2;
SOCS3 SH2;
STAT5 SH2
-
0.36
- low
Y 456 PPTPPHLKYLYLVVSDSGIST - 12027890
LTP
1.00
CISH SH2;
CRKL SH2;
INPP5D SH2;
PLCG2 SH2;
SOCS3 SH2;
STAT5 SH2
-
0.36
- low
Y 504 IPAAEPLPPSYVACS       - 10579919
LTP
0.67
INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PLCG2 SH2;
STAT5 SH2
-
0.34
- low
Y 504 IPAAEPLPPSYVACS       - 7559499
LTP
0.67
INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PLCG2 SH2;
STAT5 SH2
-
0.34
- low
Y 504 IPAAEPLPPSYVACS       - 9573010
LTP
0.67
INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PLCG2 SH2;
STAT5 SH2
-
0.34
- low

Substrate: CD150 (T cell antigen receptor)
Seq-ID: Q13291 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 281 TTVEKKSLTIYAQVQKPGPLQ Fyn 11806999
LTP
1.00
FGR SH2;
INPP5D SH2;
PTPN11 SH2;
SH2D1A SH2;
SH2D1B SH2
-
0.39
- low
Y 281 TTVEKKSLTIYAQVQKPGPLQ - 18083107
HTP
1.00
FGR SH2;
INPP5D SH2;
PTPN11 SH2;
SH2D1A SH2;
SH2D1B SH2
-
0.39
- low
Y 307 FPAQDPCTTIYVAATEPVPES Fyn 11806999
LTP
1.00
INPP5D SH2;
PTPN11 SH2;
SH2D1A SH2;
SH2D1B SH2
-
0.40
- low
Y 307 FPAQDPCTTIYVAATEPVPES Lck 11806999
LTP
1.00
INPP5D SH2;
PTPN11 SH2;
SH2D1A SH2;
SH2D1B SH2
-
0.40
- low
Y 327 SVQETNSITVYASVTLPES   Fyn 11806999
LTP
1.00
FGR SH2;
INPP5D SH2;
PTPN11 SH2;
SH2D1A SH2;
SH2D1B SH2
-
0.38
- low
Y 327 SVQETNSITVYASVTLPES   Lyn 15315965
LTP
1.00
FGR SH2;
INPP5D SH2;
PTPN11 SH2;
SH2D1A SH2;
SH2D1B SH2
-
0.38
- low

Substrate: DOK3 (Docking proteins interact with receptor tyrosine kinases)
Seq-ID: Q7L591 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
insulin receptor binding plasma membrane,
cytoplasm
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 381 PEPNDLASGLYASVCKRASGP - 16497976
HTP
1.00
Csk SH2;
INPP5D SH2
-
0.58
- medium

Substrate: IL-4R alpha (Cytokin receptor)
Seq-ID: P24394 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 713 LVDSLGSGIVYSALTCHLCGH - 9670964
LTP
1.00
INPP5D SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2
-
0.17
- medium

Substrate: FCGR2B (protein binding)
Seq-ID: P31994 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 292 DKVGAENTITYSLLMHPDALE Lyn 8756631
LTP
1.00
INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2
-
0.42
- low
Y 292 DKVGAENTITYSLLMHPDALE BLK 8756631
LTP
1.00
INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2
-
0.42
- low

Substrate: c-met (Receptor tyrosine kinase for hepatocyte growth factor.)
Seq-ID: P08581 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1356 GEHYVHVNATYVNVKCVAPYP - 12475979
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 9444958
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 9252406
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 7513258
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP Met 7731718
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 8662889
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP Met 7961992
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP Met 7687741
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 9826708
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%

Substrate: p62DOK (Docking protein, common target of PTKs)
Seq-ID: Q99704 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 203 QILEPLLSWPYTLLRRYGRDK - 12087092
LTP
1.00
CRKL SH2;
INPP5D SH2
PTBI
0.17
2V76 5.24%
Y 362 KLTDPKEDPIYDEPEGLAPVP - 12087092
LTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2
-
0.82
--
Y 362 KLTDPKEDPIYDEPEGLAPVP INSR 11551902
LTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2
-
0.82
--
Y 362 KLTDPKEDPIYDEPEGLAPVP - 10688886
LTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2
-
0.82
--
Y 362 KLTDPKEDPIYDEPEGLAPVP - 15592455
HTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2
-
0.82
--
Y 362 KLTDPKEDPIYDEPEGLAPVP - 16094384
HTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2
-
0.82
--
Y 377 GLAPVPPQGLYDLPREPKDAW - 12087092
LTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
RASA_group SH2
-
0.62
--
Y 377 GLAPVPPQGLYDLPREPKDAW - 10688886
LTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
RASA_group SH2
-
0.62
--
Y 377 GLAPVPPQGLYDLPREPKDAW - 15592455
HTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
RASA_group SH2
-
0.62
--
Y 377 GLAPVPPQGLYDLPREPKDAW - 16094384
HTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
RASA_group SH2
-
0.62
--


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