List of substrates found:

PYK2  Insulin receptor substrate 1  TRKA  c-kit  ErbB2 


Substrate: PYK2 (Focal adhesion kinase 2)
Seq-ID: Q14289 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 402 SESCSIESDIYAEIPDETLRR SYK 8816475
LTP
1.00
Fyn SH2;
MATK SH2;
Src SH2
-
0.37
--
Y 402 SESCSIESDIYAEIPDETLRR - 9560226
LTP
1.00
Fyn SH2;
MATK SH2;
Src SH2
-
0.37
--
Y 402 SESCSIESDIYAEIPDETLRR PYK2 15105428
LTP
1.00
Fyn SH2;
MATK SH2;
Src SH2
-
0.37
--

Substrate: Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID: P35568 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 662 RHPQRVDPNGYMMMSPSGGCS - 15592455
HTP
1.00
Fyn SH2;
MATK SH2;
PIK3R1 SH2;
PTPN11 SH2
-
0.77
--

Substrate: TRKA (Required for high affinity binding to nerve growth factor , neurotrophin-3 and neurotrophin-4/5r.)
Seq-ID: P04629 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 791 LQALAQAPPVYLDVLG      TRKA 11159935
LTP
1.00
MATK SH2;
PLCG1 SH2;
SHC1 SH2
-
0.11
- medium
Y 791 LQALAQAPPVYLDVLG      TRKA 8155326
LTP
1.00
MATK SH2;
PLCG1 SH2;
SHC1 SH2
-
0.11
- medium

Substrate: c-kit (Receptor tyrosine kinase)
Seq-ID: P10721 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 568 KVVEEINGNNYVYIDPTQLPY Kit 9799234
LTP
1.00
Fyn SH2;
MATK SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2
-
0.13
--
Y 570 VEEINGNNYVYIDPTQLPYDH Kit 9799234
LTP
1.00
Fyn SH2;
MATK SH2;
PTPN6 SH2;
SHC1 SH2
-
0.13
--
Y 721 ESSCSDSTNEYMDMKPGVSYV - N.N.
LTP
1.00
MATK SH2;
PIK3R1 SH2;
PIK3R2 SH2;
SHC1 SH2
TyrKc
0.36
--
Y 721 ESSCSDSTNEYMDMKPGVSYV - 9038210
LTP
1.00
MATK SH2;
PIK3R1 SH2;
PIK3R2 SH2;
SHC1 SH2
TyrKc
0.36
--

Substrate: ErbB2 (Receptor tyrosine kinase)
Seq-ID: P04626 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1248 KGTPTAENPEYLGLDVPV    ErbB2 11500516
LTP
1.00
MATK SH2 -
0.69
- low
Y 1248 KGTPTAENPEYLGLDVPV    - 17081983
HTP
1.00
MATK SH2 -
0.69
- low


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