a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

PYK2  Insulin receptor substrate 1  TRKA  c-kit  ErbB2 

Substrate:	PYK2 (Focal adhesion kinase 2)
Seq-ID:	Q14289 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	MINT-68515   PDC6I_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process non-membrane spanning protein tyrosine kinase activity, ATP binding, signal transducer activity positive regulation of cell proliferation, signal complex assembly, apoptosis
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	402	SESCSIESDIYAEIPDETLRR	SYK	8816475	LTP	1.00		Fyn SH2; MATK SH2; Src SH2	-	0.37	-	-
Y	402	SESCSIESDIYAEIPDETLRR	-	9560226	LTP	1.00		Fyn SH2; MATK SH2; Src SH2	-	0.37	-	-
Y	402	SESCSIESDIYAEIPDETLRR	PYK2	15105428	LTP	1.00		Fyn SH2; MATK SH2; Src SH2	-	0.37	-	-

Substrate:	Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID:	P35568 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-19010   INSR_HUMAN MINT-68735   P85A_HUMAN MINT-74551   EGFR_HUMAN MINT-74553   ERBB2_HUMAN MINT-3975430   1433S_HUMAN MINT-6628637   LT_SV40 MINT-6793745   PTN1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process phosphoinositide 3-kinase binding, protein kinase C binding, insulin-like growth factor receptor binding, insulin receptor binding, transmembrane receptor protein tyrosine kinase docking protein activity, SH2 domain binding microsome, caveola, cytosol, insulin receptor complex, nucleus negative regulation of insulin receptor signaling pathway, glucose homeostasis, positive regulation of insulin receptor signaling pathway, positive regulation of fatty acid beta-oxidation, phosphoinositide 3-kinase cascade, negative regulation of insulin secretion, positive regulation of glycogen biosynthetic process, insulin receptor signaling pathway, positive regulation of glucose import, positive regulation of phosphoinositide 3-kinase activity
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	662	RHPQRVDPNGYMMMSPSGGCS	-	15592455	HTP	1.00		Fyn SH2; MATK SH2; PIK3R1 SH2; PTPN11 SH2	-	0.77	-	-

Substrate:	TRKA (Required for high affinity binding to nerve growth factor , neurotrophin-3 and neurotrophin-4/5r.)
Seq-ID:	P04629 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	MINT-6793941   PTN1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process transmembrane receptor protein tyrosine kinase activity, neurotrophin receptor activity, ATP binding endosome, integral to plasma membrane activation of adenylate cyclase activity, Ras protein signal transduction, transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	791	LQALAQAPPVYLDVLG	TRKA	11159935	LTP	1.00		MATK SH2; PLCG1 SH2; SHC1 SH2	-	0.11	-	medium
Y	791	LQALAQAPPVYLDVLG	TRKA	8155326	LTP	1.00		MATK SH2; PLCG1 SH2; SHC1 SH2	-	0.11	-	medium

Substrate:	c-kit (Receptor tyrosine kinase)
Seq-ID:	P10721 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process receptor signaling protein tyrosine kinase activity, ATP binding, protein binding integral to membrane, extracellular space male gonad development, transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	568	KVVEEINGNNYVYIDPTQLPY	Kit	9799234	LTP	1.00		Fyn SH2; MATK SH2; PTPN11 SH2; PTPN6 SH2; SHC1 SH2	-	0.13	-	-
Y	570	VEEINGNNYVYIDPTQLPYDH	Kit	9799234	LTP	1.00		Fyn SH2; MATK SH2; PTPN6 SH2; SHC1 SH2	-	0.13	-	-
Y	721	ESSCSDSTNEYMDMKPGVSYV	-	N.N.	LTP	1.00		MATK SH2; PIK3R1 SH2; PIK3R2 SH2; SHC1 SH2	TyrKc	0.36	-	-
Y	721	ESSCSDSTNEYMDMKPGVSYV	-	9038210	LTP	1.00		MATK SH2; PIK3R1 SH2; PIK3R2 SH2; SHC1 SH2	TyrKc	0.36	-	-

Substrate:	ErbB2 (Receptor tyrosine kinase)
Seq-ID:	P04626 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-61505   P85B_HUMAN MINT-74429   ABL1_HUMAN MINT-74444   ABL2_HUMAN MINT-74462   ANS1A_HUMAN MINT-74470   APBB1_HUMAN MINT-74486   BLNK_HUMAN MINT-74488   BMX_HUMAN MINT-74498   CRK_HUMAN MINT-74502   CRKL_HUMAN MINT-74508   DAB1_HUMAN MINT-74512   DOK1_HUMAN MINT-74521   SPT6H_HUMAN MINT-74533   FER_HUMAN MINT-74538   FGR_HUMAN MINT-74540   GRAP2_HUMAN MINT-74542   GRB2_HUMAN MINT-74544   GRB7_HUMAN MINT-74553   IRS1_HUMAN MINT-74556   IRS4_HUMAN MINT-74558   ITK_HUMAN MINT-74561   JAK1_HUMAN MINT-74567   SH2B3_HUMAN MINT-74575   JIP1_HUMAN MINT-74582   MATK_HUMAN MINT-74590   NCK2_HUMAN MINT-74610   P85A_HUMAN MINT-74664   P55G_HUMAN MINT-74680   PLCG1_HUMAN MINT-74686   PLCG2_HUMAN MINT-74691   PTN11_HUMAN MINT-74712   RASA1_HUMAN MINT-74713   RIN1_HUMAN MINT-74722   SH22A_HUMAN MINT-74723   SH23A_HUMAN MINT-74724   3BP2_HUMAN MINT-74737   SHC1_HUMAN MINT-74747   SLAP1_HUMAN MINT-74755   STAT1_HUMAN MINT-74756   STAT3_HUMAN MINT-74769   KSYK_HUMAN MINT-74777   TEC_HUMAN MINT-74781   TENC1_HUMAN MINT-74786   TENS3_HUMAN MINT-74793   TLN1_HUMAN MINT-74794   TXK_HUMAN MINT-74802   VAV2_HUMAN MINT-1788719   EGFR_HUMAN MINT-1901925   LAP2_MOUSE
GO-Terms:	[show] Molecular Function Cellular Component Biological Process epidermal growth factor receptor activity, ErbB-3 class receptor binding, protein heterodimerization activity, DNA binding, protein C-terminus binding, identical protein binding, receptor signaling protein tyrosine kinase activity, ATP binding, protein phosphatase binding receptor complex, integral to membrane, nucleus, perinuclear region of cytoplasm regulation of angiogenesis, transcription, regulation of transcription, phosphoinositide 3-kinase cascade, phosphoinositide-mediated signaling, heart development, positive regulation of cell adhesion, protein amino acid autophosphorylation, positive regulation of epithelial cell proliferation, wound healing, positive regulation of MAP kinase activity, cell proliferation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1248	KGTPTAENPEYLGLDVPV	ErbB2	11500516	LTP	1.00		MATK SH2	-	0.69	-	low
Y	1248	KGTPTAENPEYLGLDVPV	-	17081983	HTP	1.00		MATK SH2	-	0.69	-	low