List of substrates found:

CBL E3 ubiquitin protein ligase  Gab1  Insulin receptor substrate 1  c-kit  PDGF-R beta  TIE2 (TEK) 


Substrate: CBL E3 ubiquitin protein ligase (Adaptor molecule)
Seq-ID: P22681 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 337 ALIDGFREGFYLFPDGRNQNP - 10608804
LTP
1.00
CRKL SH2;
CRK SH2;
PIK3R2 SH2
Cbl_N3
0.18
1YVH 9.61%
Y 700 EQCEGEEDTEYMTPSSRPLRP Fyn 9525940
LTP
0.63
CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2
-
0.85
--
Y 700 EQCEGEEDTEYMTPSSRPLRP SYK 9525940
LTP
0.63
CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2
-
0.85
--
Y 700 EQCEGEEDTEYMTPSSRPLRP Yes 9525940
LTP
0.63
CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2
-
0.85
--
Y 700 EQCEGEEDTEYMTPSSRPLRP - 9102067
LTP
0.63
CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2
-
0.85
--
Y 700 EQCEGEEDTEYMTPSSRPLRP - 12522270
HTP
0.63
CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2
-
0.85
--
Y 700 EQCEGEEDTEYMTPSSRPLRP INSR 11997497
LTP
0.63
CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2
-
0.85
--
Y 700 EQCEGEEDTEYMTPSSRPLRP - 10829062
LTP
0.63
CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2
-
0.85
--
Y 700 EQCEGEEDTEYMTPSSRPLRP - 15922744
LTP
0.63
CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2
-
0.85
--
Y 731 DCDQQIDSCTYEAMYNIQSQA Fyn 9525940
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 731 DCDQQIDSCTYEAMYNIQSQA SYK 9525940
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 731 DCDQQIDSCTYEAMYNIQSQA Yes 9525940
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 731 DCDQQIDSCTYEAMYNIQSQA - 10934191
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 731 DCDQQIDSCTYEAMYNIQSQA Fyn 9890970
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 731 DCDQQIDSCTYEAMYNIQSQA - 12604776
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 731 DCDQQIDSCTYEAMYNIQSQA - 15922744
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--

Substrate: Gab1 (Multisubstrate docking protein downstream in the signaling pathways of different RTK.)
Seq-ID: Q13480 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 447 SVSSEELDENYVPMNPNSPPR INSR 10978177
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2;
PTPN11 SH2
-
0.83
- low
Y 447 SVSSEELDENYVPMNPNSPPR EGFR 9890893
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2;
PTPN11 SH2
-
0.83
- low
Y 447 SVSSEELDENYVPMNPNSPPR Met 10734310
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2;
PTPN11 SH2
-
0.83
- low
Y 472 SFTEPIQEANYVPMTPGTFDF INSR 10978177
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2
-
0.54
- low
Y 472 SFTEPIQEANYVPMTPGTFDF EGFR 9890893
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2
-
0.54
- low
Y 472 SFTEPIQEANYVPMTPGTFDF Met 10734310
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2
-
0.54
- low

Substrate: Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID: P35568 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 612 DSSTLHTDDGYMPMSPGVAPV - 15001544
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2
-
0.81
--
Y 612 DSSTLHTDDGYMPMSPGVAPV - 18083107
HTP
1.00
PIK3R1 SH2;
PIK3R2 SH2
-
0.81
--
Y 632 VPSGRKGSGDYMPMSPKSVSA - 15001544
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2
-
0.83
--
Y 632 VPSGRKGSGDYMPMSPKSVSA - 18083107
HTP
1.00
PIK3R1 SH2;
PIK3R2 SH2
-
0.83
--

Substrate: c-kit (Receptor tyrosine kinase)
Seq-ID: P10721 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 721 ESSCSDSTNEYMDMKPGVSYV - N.N.
LTP
1.00
MATK SH2;
PIK3R1 SH2;
PIK3R2 SH2;
SHC1 SH2
TyrKc
0.36
--
Y 721 ESSCSDSTNEYMDMKPGVSYV - 9038210
LTP
1.00
MATK SH2;
PIK3R1 SH2;
PIK3R2 SH2;
SHC1 SH2
TyrKc
0.36
--

Substrate: PDGF-R beta (Beta platelet-derived growth factor receptor)
Seq-ID: P09619 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 751 MDMSKDESVDYVPMLDMKGDV PDGFR_beta 8195171
LTP
1.00
Fyn SH2;
NCK SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2;
Src SH2
TyrKc
0.29
- medium
Y 751 MDMSKDESVDYVPMLDMKGDV PDGFR_group 8195171
LTP
1.00
Fyn SH2;
NCK SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2;
Src SH2
TyrKc
0.29
- medium

Substrate: TIE2 (TEK) (PTK receptor for angiopoietin 1)
Seq-ID: Q02763 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1102 LNRMLEERKTYVNTTLYEKFT - 10521483
LTP
1.00
GRB2 SH2;
GRB7 SH2;
PIK3R1 SH2;
PIK3R2 SH2;
SHC1 SH2
-
0.15
1FVR 3.49%
Y 1102 LNRMLEERKTYVNTTLYEKFT - 9632797
LTP
1.00
GRB2 SH2;
GRB7 SH2;
PIK3R1 SH2;
PIK3R2 SH2;
SHC1 SH2
-
0.15
1FVR 3.49%
Y 1102 LNRMLEERKTYVNTTLYEKFT TIE2 12082108
LTP
1.00
GRB2 SH2;
GRB7 SH2;
PIK3R1 SH2;
PIK3R2 SH2;
SHC1 SH2
-
0.15
1FVR 3.49%


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