List of substrates found:

Tpo-R  INF-alpha REC  EGFR  G-CSF-R  BMX  GH-R  IL-6R (gp130)  Leptin receptor  STAT 3  ErbB2  c-met  FAK 


Substrate: Tpo-R (Thrombopoietin R mlp belongs to the hematopoietic R superfamily)
Seq-ID: P40238 [Homo sapiens]
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cytokine receptor activity integral to plasma membrane cell proliferation
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 631 IANHSYLPLSYWQQP       - 9122198
LTP
0.68
STAT3 SH2 -
0.23
- medium

Substrate: INF-alpha REC (Interferon receptor)
Seq-ID: P17181 [Homo sapiens]
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 466 AAKVFLRCINYVFFPSLKPSS Tyk2 8605876
LTP
1.00
STAT1 SH2;
STAT2 SH2;
STAT3 SH2;
TYK2 SH2
-
0.03
- low
Y 466 AAKVFLRCINYVFFPSLKPSS Tyk2 8700538
LTP
1.00
STAT1 SH2;
STAT2 SH2;
STAT3 SH2;
TYK2 SH2
-
0.03
- low

Substrate: EGFR (Receptor for EGF and other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor,)
Seq-ID: P00533 [Homo sapiens]
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1092 IDDTFLPVPEYINQSVPKRPA EGFR 8845374
LTP
0.05
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2
-
0.57
--
Y 1092 IDDTFLPVPEYINQSVPKRPA - 15302935
HTP
0.05
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2
-
0.57
--
Y 1092 IDDTFLPVPEYINQSVPKRPA - 17081983
HTP
0.05
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2
-
0.57
--
Y 1092 IDDTFLPVPEYINQSVPKRPA - 18083107
HTP
0.05
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2
-
0.57
--
Y 1110 RPAGSVQNPVYHNQPLNPAPS EGFR 8845374
LTP
1.00
GRB2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 PTB;
Src SH2;
STAT3 SH2
-
0.80
--
Y 1110 RPAGSVQNPVYHNQPLNPAPS - 15302935
HTP
1.00
GRB2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 PTB;
Src SH2;
STAT3 SH2
-
0.80
--

Substrate: G-CSF-R (Granulocyte colony stimulating factor receptor)
Seq-ID: P40223 [Mus musculus]
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cytokine receptor activity integral to membrane neutrophil chemotaxis,
cell adhesion
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 728 NGSLPALVQAYVLQGDPREIS - 8608222
LTP
1.00
PTPN11 SH2;
STAT3 SH2
-
0.41
- medium
Y 728 NGSLPALVQAYVLQGDPREIS - 10329697
LTP
1.00
PTPN11 SH2;
STAT3 SH2
-
0.41
- medium
Y 768 ESPTSPGVMQYIRSDSTQPLL - 8608222
LTP
1.00
STAT3 SH2 -
0.64
- medium

Substrate: G-CSF-R (Granulocyte colony stimulating factor receptor)
Seq-ID: Q99062 [Homo sapiens]
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 727 TCGLPTLVQTYVLQGDPRAVS - 12133942
LTP
1.00
STAT3 SH2 -
0.36
- medium

Substrate: BMX (Tyrosine kinase)
Seq-ID: P51813 [Homo sapiens]
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 224 AQYDSNSKKIYGSQPNFNMQY BTK 12573241
LTP
- STAT3 SH2 -
0.44
- medium
Y 224 AQYDSNSKKIYGSQPNFNMQY TEC 12573241
LTP
- STAT3 SH2 -
0.44
- medium

Substrate: GH-R (Growth hormon receptor)
Seq-ID: P10912 [Homo sapiens]
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 487 NPSSLSNIDFYAQVSDITPAG JAK2 9121492
LTP
1.00
CISH SH2;
GRB10 SH2;
SOCS2 SH2;
STAT3 SH2;
STAT5 SH2
-
0.42
- low
Y 534 CQENFLMDNAYFCEADAKKCI - 9121492
LTP
0.93
GRB10 SH2;
STAT3 SH2;
STAT5 SH2
-
0.16
- low
Y 534 CQENFLMDNAYFCEADAKKCI - 8647880
LTP
0.93
GRB10 SH2;
STAT3 SH2;
STAT5 SH2
-
0.16
- low
Y 566 IQPSLNQEDIYITTESLTTAA - 9121492
LTP
1.00
GRB10 SH2;
STAT3 SH2;
STAT5 SH2
-
0.47
- low
Y 566 IQPSLNQEDIYITTESLTTAA - 8647880
LTP
1.00
GRB10 SH2;
STAT3 SH2;
STAT5 SH2
-
0.47
- low
Y 627 PDKEFLSSCGYVSTDQLNKIM - 9121492
LTP
1.00
STAT3 SH2;
STAT5 SH2
-
0.29
- low
Y 627 PDKEFLSSCGYVSTDQLNKIM - 8647880
LTP
1.00
STAT3 SH2;
STAT5 SH2
-
0.29
- low

Substrate: IL-6R (gp130) (gp130 is shared by members of the IL-6 family)
Seq-ID: P40189 [Homo sapiens]
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 767 VQYSTVVHSGYRHQVPSVQVF - 8612579
LTP
1.00
STAT3 SH2 -
0.45
- medium
Y 767 VQYSTVVHSGYRHQVPSVQVF - 10661409
LTP
1.00
STAT3 SH2 -
0.45
- medium
Y 814 GGDGILPRQQYFKQNCSQHES - 8612579
LTP
1.00
STAT3 SH2 -
0.61
- medium
Y 814 GGDGILPRQQYFKQNCSQHES - 10661409
LTP
1.00
STAT3 SH2 -
0.61
- medium
Y 905 AATDEGMPKSYLPQTVRQGGY - 8612579
LTP
1.00
STAT1 SH2;
STAT3 SH2
-
0.70
- medium
Y 905 AATDEGMPKSYLPQTVRQGGY - 10661409
LTP
1.00
STAT1 SH2;
STAT3 SH2
-
0.70
- medium
Y 915 YLPQTVRQGGYMPQ        - 8612579
LTP
1.00
STAT1 SH2;
STAT3 SH2
-
0.64
- medium
Y 915 YLPQTVRQGGYMPQ        - 10661409
LTP
1.00
STAT1 SH2;
STAT3 SH2
-
0.64
- medium

Substrate: Leptin receptor (Receptor for the obesity factor Leptin; it belongs to the cytokine receptor family)
Seq-ID: P48356 [Mus musculus]
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1138 LGTSGENFVPYMPQFQTCSTH - 10799542
LTP
0.97
STAT3 SH2 -
0.29
--

Substrate: Leptin receptor (Receptor for the obesity factor Leptin; it belongs to the cytokine receptor family)
Seq-ID: P48357 [Homo sapiens]
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1141 GTSSKKTFASYMPQFQTCSTQ - 14625304
LTP
1.00
STAT3 SH2 -
0.29
- medium

Substrate: STAT 3 (Transcription factor)
Seq-ID: P40763 [Homo sapiens]
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 705 PEADPGSAAPYLKTKFICVTP - 9083098
LTP
0.63
STAT3 SH2 -
0.34
1BG1 138.86%
Y 705 PEADPGSAAPYLKTKFICVTP - 11429593
LTP
0.63
STAT3 SH2 -
0.34
1BG1 138.86%
Y 705 PEADPGSAAPYLKTKFICVTP JAK2 9582023
LTP
0.63
STAT3 SH2 -
0.34
1BG1 138.86%
Y 705 PEADPGSAAPYLKTKFICVTP - 15592455
HTP
0.63
STAT3 SH2 -
0.34
1BG1 138.86%
Y 705 PEADPGSAAPYLKTKFICVTP - 12244095
LTP
0.63
STAT3 SH2 -
0.34
1BG1 138.86%
Y 705 PEADPGSAAPYLKTKFICVTP - 14551213
LTP
0.63
STAT3 SH2 -
0.34
1BG1 138.86%
Y 705 PEADPGSAAPYLKTKFICVTP ALK 11850821
LTP
0.63
STAT3 SH2 -
0.34
1BG1 138.86%
Y 705 PEADPGSAAPYLKTKFICVTP - 9305919
LTP
0.63
STAT3 SH2 -
0.34
1BG1 138.86%
Y 705 PEADPGSAAPYLKTKFICVTP - 18083107
HTP
0.63
STAT3 SH2 -
0.34
1BG1 138.86%

Substrate: ErbB2 (Receptor tyrosine kinase)
Seq-ID: P04626 [Homo sapiens]
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1139 APLTCSPQPEYVNQPDVRPQP ErbB2 11500516
LTP
1.00
GRB2 SH2;
GRB7 SH2;
Src SH2;
STAT3 SH2
-
0.85
- low
Y 1222 AFSPAFDNLYYWDQDPPERGA ErbB2 11500516
LTP
1.00
SHC_group SH2;
STAT3 SH2
-
0.68
- low

Substrate: c-met (Receptor tyrosine kinase for hepatocyte growth factor.)
Seq-ID: P08581 [Homo sapiens]
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1313 LQPEYCPDPLYEVMLKCWHPK - 7708691
LTP
0.97
PIK3R1 SH2;
STAT3 SH2
TyrKc
0.10
3F66 15.28%
Y 1313 LQPEYCPDPLYEVMLKCWHPK - 10069803
LTP
0.97
PIK3R1 SH2;
STAT3 SH2
TyrKc
0.10
3F66 15.28%

Substrate: FAK (Focal adhesion kinase)
Seq-ID: Q05397 [Homo sapiens]
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 397 HAVSVSETDDYAEIIDEEDTY FAK 7509446
LTP
1.00
Fyn SH2;
GRB2 SH2;
GRB7 SH2;
NCK SH2;
PIK3R1 SH2;
Src SH2;
STAT3 SH2
-
0.49
--
Y 397 HAVSVSETDDYAEIIDEEDTY - 17192257
HTP
1.00
Fyn SH2;
GRB2 SH2;
GRB7 SH2;
NCK SH2;
PIK3R1 SH2;
Src SH2;
STAT3 SH2
-
0.49
--
Y 397 HAVSVSETDDYAEIIDEEDTY - 18083107
HTP
1.00
Fyn SH2;
GRB2 SH2;
GRB7 SH2;
NCK SH2;
PIK3R1 SH2;
Src SH2;
STAT3 SH2
-
0.49
--
Y 925 ANLDRSNDKVYENVTGLVKAV - 12370821
LTP
1.00
GRB2 SH2;
STAT3 SH2
Focal_AT
0.45
1K04 39.30%
Y 925 ANLDRSNDKVYENVTGLVKAV - 7997267
LTP
1.00
GRB2 SH2;
STAT3 SH2
Focal_AT
0.45
1K04 39.30%


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