List of substrates found:

SYK  ZAP70  SH3 domain-binding protein 2  SLP-76  LAT  CD19 


Substrate: SYK (Spleen tyrosine kinase )
Seq-ID: P43405 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-56730   LCK_HUMAN
MINT-56732   P85A_HUMAN
MINT-56739   FGR_HUMAN
MINT-56749   P85B_HUMAN
MINT-74763   EGFR_HUMAN
MINT-74769   ERBB2_HUMAN
MINT-74775   ERBB3_HUMAN
MINT-74776   ERBB4_HUMAN
MINT-6538977   CBL_HUMAN
MINT-6621148   BLNK_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
integrin binding		 cytoplasm,
T cell receptor complex		 protein complex assembly,
organ morphogenesis,
integrin-mediated signaling pathway,
neutrophil chemotaxis,
interspecies interaction between organisms,
cell proliferation,
leukocyte cell-cell adhesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 348 REALPMDTEVYESPYADPEEI SYK 8657103
LTP
0.93
 FGR SH2;
Lck SH2;
PLCG1 SH2;
VAV1 SH2		 -
0.59
 --
Y 348 REALPMDTEVYESPYADPEEI - 12522270
HTP
0.93
 FGR SH2;
Lck SH2;
PLCG1 SH2;
VAV1 SH2		 -
0.59
 --
Y 348 REALPMDTEVYESPYADPEEI - 18083107
HTP
0.93
 FGR SH2;
Lck SH2;
PLCG1 SH2;
VAV1 SH2		 -
0.59
 --
Y 352 PMDTEVYESPYADPEEIRPKE SYK 8657103
LTP
1.00
 FGR SH2;
Lck SH2;
PLCG1 SH2;
VAV1 SH2		 -
0.53
 --
Y 352 PMDTEVYESPYADPEEIRPKE - 12522270
HTP
1.00
 FGR SH2;
Lck SH2;
PLCG1 SH2;
VAV1 SH2		 -
0.53
 --
Y 352 PMDTEVYESPYADPEEIRPKE - 18083107
HTP
1.00
 FGR SH2;
Lck SH2;
PLCG1 SH2;
VAV1 SH2		 -
0.53
 --

Substrate: SYK (Spleen tyrosine kinase )
Seq-ID: P48025 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-56734   P85A_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor signaling protein tyrosine kinase activity,
non-membrane spanning protein tyrosine kinase activity,
ATP binding		 B cell receptor complex,
cytoplasm		 positive regulation of peptidyl-tyrosine phosphorylation,
positive regulation of interleukin-3 biosynthetic process,
B cell receptor signaling pathway,
serotonin secretion,
positive regulation of alpha-beta T cell proliferation,
positive regulation of calcium-mediated signaling,
positive regulation of B cell differentiation,
activation of JUN kinase activity,
positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process,
beta selection,
positive regulation of gamma-delta T cell differentiation,
positive regulation of mast cell degranulation,
leukotriene biosynthetic process,
protein amino acid autophosphorylation,
enzyme linked receptor protein signaling pathway,
peptidyl-tyrosine phosphorylation,
positive regulation of alpha-beta T cell differentiation,
G-protein coupled receptor protein signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 342 REALPMDTEVYESPYADPEEI SYK 8657103
LTP
1.00
 PLCG_group SH2;
VAV1 SH2		 -
0.58
 --
Y 342 REALPMDTEVYESPYADPEEI Lyn 9820500
LTP
1.00
 PLCG_group SH2;
VAV1 SH2		 -
0.58
 --

Substrate: ZAP70 (Cytoplasmic tyrosine kinase)
Seq-ID: P43403 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-59476   LCK_HUMAN
MINT-60980   SHC1_HUMAN
MINT-74806   ERBB3_HUMAN
MINT-74807   EGFR_HUMAN
MINT-3374106   HS90A_HUMAN
MINT-3382488   LAT_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
non-membrane spanning protein tyrosine kinase activity,
ATP binding		 cytosol,
T cell receptor complex		 positive thymic T cell selection,
immune response,
intracellular protein kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 315 PRPMPMDTSVYESPYSDPEEL ZAP70 11828374
LTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL ZAP70 7798261
LTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL - 12522270
HTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL - 15592455
HTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL - 16094384
HTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL ZAP70 10037717
LTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%

Substrate: SH3 domain-binding protein 2 (Adaptor molecule)
Seq-ID: P78314 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-17097   1433T_HUMAN
MINT-74724   ERBB2_HUMAN
MINT-4549720   VAV_HUMAN
MINT-4563345   DBNL_HUMAN
MINT-4563367   SH3K1_HUMAN
MINT-7301276   VAV2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
SH3/SH2 adaptor activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 183 DYEHDDEDDSYLEPDSPEPGR - 11390470
LTP
1.00
 PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV2 SH2;
VAV_group SH2		 -
0.89
 - medium

Substrate: SH3 domain-binding protein 2 (Adaptor molecule)
Seq-ID: Q06649 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 183 DYEHEDEDDSYLEPDSPGPMK - 12709437
LTP
1.00
 VAV1 SH2 -
0.85
 - low
Y 446 DTGEEDSDEDYEKVPLPNSVF - 12709437
LTP
1.00
 Lck SH2;
Lyn SH2;
VAV1 SH2		 -
0.70
 - low

Substrate: SLP-76 (Adaptor molecule; involved in T cell AG receptor mediate signaling)
Seq-ID: Q13094 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-15244   FYB_HUMAN
MINT-16513   SHC1_HUMAN
MINT-16846   CBL_HUMAN
MINT-17488   FCGR1_HUMAN
MINT-59471   ITK_MOUSE
MINT-59473   ITK_HUMAN
MINT-59474   LCK_HUMAN
MINT-2837400   PLCG1_BOVIN
MINT-4302560   STAM1_HUMAN
MINT-4302608   STAM2_HUMAN
MINT-7041321   GRAP2_HUMAN
MINT-7306527   NCK1_HUMAN
MINT-7306585   SRC_CHICK
MINT-7306598   SRC_HUMAN
MINT-7306611   FYN_HUMAN
MINT-7306624   P85A_HUMAN
MINT-7306637   PLCG1_HUMAN
MINT-7306657   GRB2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein binding cytosol immune response,
transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 113 GGWSSFEEDDYESPNDDQDGE - 8892604
LTP
0.99
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.92
 - medium
Y 113 GGWSSFEEDDYESPNDDQDGE ZAP70 9047237
LTP
0.99
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.92
 - medium
Y 113 GGWSSFEEDDYESPNDDQDGE SYK 15388330
LTP
0.99
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.92
 - medium
Y 113 GGWSSFEEDDYESPNDDQDGE ZAP70 12817019
LTP
0.99
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.92
 - medium
Y 113 GGWSSFEEDDYESPNDDQDGE Lck 8702662
LTP
0.99
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.92
 - medium
Y 113 GGWSSFEEDDYESPNDDQDGE ZAP70 8702662
LTP
0.99
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.92
 - medium
Y 128 DDQDGEDDGDYESPNEEEEAP - 8892604
LTP
0.30
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.98
 - medium
Y 128 DDQDGEDDGDYESPNEEEEAP ZAP70 9047237
LTP
0.30
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.98
 - medium
Y 128 DDQDGEDDGDYESPNEEEEAP SYK 15388330
LTP
0.30
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.98
 - medium
Y 128 DDQDGEDDGDYESPNEEEEAP ZAP70 12817019
LTP
0.30
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.98
 - medium
Y 128 DDQDGEDDGDYESPNEEEEAP Lck 8702662
LTP
0.30
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.98
 - medium
Y 128 DDQDGEDDGDYESPNEEEEAP ZAP70 8702662
LTP
0.30
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.98
 - medium
Y 145 EEAPVEDDADYEPPPSNDEEA TXK 8892604
LTP
1.00
 ITK SH2;
NCK SH2;
PTPN6 SH2;
VAV1 SH2		 -
0.97
 - medium
Y 145 EEAPVEDDADYEPPPSNDEEA ZAP70 8892604
LTP
1.00
 ITK SH2;
NCK SH2;
PTPN6 SH2;
VAV1 SH2		 -
0.97
 - medium

Substrate: LAT (Adaptor molecule involved in the TCR signal pathway)
Seq-ID: O43561 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-3382436   GRB2_HUMAN
MINT-3382457   SOS1_MOUSE
MINT-3382488   ZAP70_HUMAN
MINT-6794135   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3/SH2 adaptor activity immunological synapse,
integral to membrane,
membrane raft		 calcium-mediated signaling,
integrin-mediated signaling pathway,
mast cell degranulation,
regulation of T cell activation,
Ras protein signal transduction
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 220 AEASLDGSREYVNVSQELHPG - 15659558
HTP
1.00
 GRAP2 SH2;
GRB2 SH2;
PIK3R1 SH2;
PLCG1 SH2;
VAV1 SH2		 -
0.71
 - medium

Substrate: CD19 (Antigen of human B-lymphocytes)
Seq-ID: P15391 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor signaling protein activity,
protein binding		 integral to plasma membrane cellular defense response
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 409 VGPEEEEGEGYEEPDSEEDSE - 10706702
LTP
1.00
 PLCG2 SH2;
VAV1 SH2;
VAV2 SH2;
VAV_group SH2		 -
0.97
 - medium

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