Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

Substrate:

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (Enzyme: Phosphotransferase)

Seq-ID:

O60825 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-3304235 1433Z_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
6-phosphofructo-2-kinase activity, fructose-2,6-bisphosphate 2-phosphatase activity, ATP binding	cytosol	fructose 2,6-bisphosphate metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	466	NQTPVRMRRNSFTPLSSSNTI	AMPK_group	12853467	LTP	0.58	MOD_PKB_1	-	-	0.63	-	low

Substrate:

ACACB (Enzyme: carboxylase)

Seq-ID:

O00763 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-7543070 BPL1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
metal ion binding, acetyl-CoA carboxylase activity, biotin carboxylase activity, ATP binding, biotin binding, protein binding	cytosol, Golgi apparatus, membrane, endomembrane system	fatty acid biosynthetic process, regulation of fatty acid oxidation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	222	TRVPTMRPSMSGLHLVKRGRE	AMPK_group	12488245	LTP	0.17		-	-	0.62	-	medium

Substrate:

Acetyl-CoA carboxylase 1 (Enzyme: Carboxylase)

Seq-ID:

P11497 [Rattus norvegicus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
metal ion binding, acetyl-CoA carboxylase activity, biotin carboxylase activity, ATP binding, biotin binding	soluble fraction	response to organic cyclic substance, acetyl-CoA metabolic process, response to drug, fatty acid biosynthetic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	79	GLAFHMRSSMSGLHLVKQGRD	AMPK_group	2900138	LTP	0.17		-	-	0.34	-	low
S	1200	RGNIPTLNRMSFASNLNHYGM	AMPK_group	7915280	LTP	0.83	MOD_PKA_2	-	ACC_central	0.27	-	low
S	1200	RGNIPTLNRMSFASNLNHYGM	AMPK_group	2900138	LTP	0.83	MOD_PKA_2	-	ACC_central	0.27	-	low
S	1200	RGNIPTLNRMSFASNLNHYGM	AMPK_group	1967580	LTP	0.83	MOD_PKA_2	-	ACC_central	0.27	-	low
S	1215	LNHYGMTHVASVSDVLLDNAF	AMPK_group	8035170	LTP	0.61		-	ACC_central	0.17	-	low

Substrate:

Acetyl-CoA carboxylase 1 (Enzyme: Carboxylase)

Seq-ID:

Q13085 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
metal ion binding, acetyl-CoA carboxylase activity, biotin carboxylase activity, ATP binding, protein binding		fatty acid biosynthetic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	80	GLALHIRSSMSGLHLVKQGRD	AMPK_group	11052978	LTP	0.20		-	-	0.32	-	medium
S	80	GLALHIRSSMSGLHLVKQGRD	AMPK_group	19176702	LTP	0.20		-	-	0.32	-	medium
S	80	GLALHIRSSMSGLHLVKQGRD	AMPK_group	18303014	LTP	0.20		-	-	0.32	-	medium
S	80	GLALHIRSSMSGLHLVKQGRD	AMPK_group	17276402	LTP	0.20		-	-	0.32	-	medium
S	80	GLALHIRSSMSGLHLVKQGRD	AMPK_group	15371448	LTP	0.20		-	-	0.32	-	medium
S	1201	RGNIPTLNRMSFSSNLNHYGM	AMPK_group	2900138	LTP	0.84	MOD_PKA_2	-	ACC_central	0.30	-	medium

Substrate:

ADR1 (regulatory protein ADR1 (from PhosphoBase))

Seq-ID:

P07248 [Saccharomyces cerevisiae]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-7929868 FUS3_YEAST

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, zinc ion binding, sequence-specific DNA binding transcription factor activity, protein binding	nucleus	transcription, peroxisome organization, regulation of carbohydrate metabolic process, negative regulation of transcription from RNA polymerase II promoter by glucose

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	230	KYLKKLTRRASFSAQSASSYA	AMPK_group	8910470	LTP	1.00	MOD_PKA_1	-	-	0.41	-	low

Substrate:

AMPK alpha 1 (Serine/threonine kinase)

Seq-ID:

P54645 [Rattus norvegicus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein C-terminus binding, metal ion binding, eukaryotic elongation factor-2 kinase activator activity, ATP binding, AMP-activated protein kinase activity	AMP-activated protein kinase complex	positive regulation of cell proliferation, protein amino acid phosphorylation, regulation of vesicle-mediated transport, cellular response to hydrogen peroxide, positive regulation of gluconeogenesis, response to activity, cellular response to ethanol, fatty acid biosynthetic process, cellular response to organic nitrogen, cellular response to hypoxia, negative regulation of translation, cholesterol biosynthetic process, response to caffeine, protein heterooligomerization, positive regulation of glucose import, positive regulation of fatty acid oxidation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	172	NMMSDGEFLRTSCGSPNYAAP	AMPK_group	8910387	LTP	0.00		-	S_TKc	0.26	-	medium

Substrate:

AMPK alpha 1 (Serine/threonine kinase)

Seq-ID:

Q13131 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-6771238 AAKB1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cAMP-dependent protein kinase activity, metal ion binding, ATP binding, protein binding	cytosol	response to hypoxia, fatty acid biosynthetic process, positive regulation of anti-apoptosis, negative regulation of glucosylceramide biosynthetic process, activation of MAPK activity, cholesterol biosynthetic process, regulation of fatty acid oxidation, positive regulation of cholesterol biosynthetic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	174	NMMSDGEFLRTSCGSPNYAAP	AMPK_group	15980064	LTP	0.00		-	S_TKc	0.26	-	medium
T	174	NMMSDGEFLRTSCGSPNYAAP	AMPK_group	19376078	LTP	0.00		-	S_TKc	0.26	-	medium

Substrate:

AMPK alpha 2 (Serine/threonine kinase)

Seq-ID:

P54646 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
metal ion binding, ATP binding	cytosol, nucleoplasm	protein amino acid phosphorylation, fatty acid biosynthetic process, signal transduction, cholesterol biosynthetic process, regulation of fatty acid oxidation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	172	NMMSDGEFLRTSCGSPNYAAP	AMPK_group	10642499	LTP	1.00		-	S_TKc	0.24	-	-

Substrate:

AMPK beta-1 chain (Regulatory/other subunit)

Seq-ID:

P80386 [Rattus norvegicus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein kinase binding, AMP-activated protein kinase activity	AMP-activated protein kinase complex	response to stress, fatty acid biosynthetic process, regulation of catalytic activity, protein heterooligomerization

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	24	QAGHKTPRRDSSGGTKDGDRP	AMPK_group	9305909	LTP	0.83	-	-	0.89	-	-
S	25	AGHKTPRRDSSGGTKDGDRPK	AMPK_group	9305909	LTP	0.62	-	-	0.88	-	-
S	108	NNWSKLPLTRSQNNFVAILDL	AMPK_group	9305909	LTP	1.00	-	-	0.34	1Z0N	35.25%

Substrate:

Carbon catabolite repressor CRES (Metal ion binding protein)

Seq-ID:

O14401 [Sclerotinia sclerotiorum]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
nucleic acid binding, zinc ion binding	intracellular

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	266	LQAYAMTRAYSHEEDDHYAHR	AMPK_group	10853770	LTP	0.68		-	-	0.67	-	low

Substrate:

Caspase-6 precursor (Cysteine-type peptidase activity)

Seq-ID:

P55212 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-63876 CHD3_HUMAN
MINT-6175501 NUCB1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cysteine-type endopeptidase activity, protein binding	cytosol, nucleoplasm	proteolysis, apoptosis, induction of apoptosis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	257	ELLTLVNRKVSQRRVDFCKDP	AMPK_group	15273717	LTP	0.19		-	CASc	0.16	-	low

Substrate:

E1A-associated protein p300 (Transcription regulatory protein)

Seq-ID:

Q09472 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13681   P73_HUMAN
MINT-17787   GATA4_MOUSE
MINT-50178   TF65_HUMAN
MINT-69559   VE7_HPV16
MINT-2584615   TF2B_HUMAN
MINT-2831131   ABL1_HUMAN
MINT-2982535   HIPK2_HUMAN
MINT-2982660   RUNX1_HUMAN
MINT-2983397   CDK2_HUMAN
MINT-4790867   ITF2_HUMAN
MINT-4791678   HIF1A_HUMAN
MINT-4979756   CREB1_MOUSE
MINT-5209851   CREB1_HUMAN
MINT-6628502   LT_SV40
MINT-6665134   E1A_ADE05
MINT-6743403   STRAP_HUMAN
MINT-7263630   P53_HUMAN
MINT-7943702   SENP3_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
histone acetyltransferase activity, beta-catenin binding, transcription coactivator activity, zinc ion binding	cytoplasm	transcription, response to hypoxia, histone H4 acetylation, apoptosis, positive regulation of transcription factor activity, cell cycle, N-terminal peptidyl-lysine acetylation, interspecies interaction between organisms, positive regulation of transcription from RNA polymerase II promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	89	KQLSELLRSGSSPNLNMGVGG	AMPK_group	11020388	LTP	0.79		-	-	0.74	-	medium
S	89	KQLSELLRSGSSPNLNMGVGG	AMPK_group	12590608	LTP	0.79		-	-	0.74	-	medium

Substrate:

eEF-2 kinase (Elongation factor 2 kinase)

Seq-ID:

O00418 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-15495   KS6B2_HUMAN
MINT-17060   KS6A1_HUMAN
MINT-6549466   CDC2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
translation factor activity, nucleic acid binding, calcium ion binding, ATP binding, elongation factor-2 kinase activity, calmodulin binding	cytosol	protein amino acid phosphorylation, translational elongation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	78	RYSSSGSPANSFHFKEAWKHA	AMPK_group	14709557	LTP	0.03	-	-	0.40	-	medium
S	366	KCGSPRVRTLSGSRPPLLRPL	AMPK_group	14709557	LTP	1.00	-	-	0.69	-	medium
S	398	VTFDSLPSSPSSATPHSQKLD	AMPK_group	14709557	LTP	0.90	-	-	0.73	-	medium

Substrate:

HMG-CoA reductase (3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) (from PhosphoBase))

Seq-ID:

P51639 [Rattus norvegicus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein homodimerization activity, hydroxymethylglutaryl-CoA reductase (NADPH) activity, hydroxymethylglutaryl-CoA reductase activity, NADP or NADPH binding	microsome, integral to membrane, endoplasmic reticulum membrane	coenzyme A metabolic process, oxidation reduction, aging, positive regulation of skeletal muscle tissue development, response to nutrient, cholesterol biosynthetic process, farnesyl diphosphate biosynthetic process, mevalonate pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	871	LVRSHMVHNRSKINLQDLQGT	AMPK_group	2369897	LTP	0.98		-	-	0.39	-	medium

Substrate:

HNF4-alpha (Nuclear receptor)

Seq-ID:

P41235 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-16696 SRBP2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein homodimerization activity, fatty acid binding, zinc ion binding, promoter binding, receptor binding, sequence-specific DNA binding transcription factor activity, steroid hormone receptor activity	cytoplasm, nucleus	regulation of growth hormone receptor signaling pathway, positive regulation of gene-specific transcription from RNA polymerase II promoter, transcription, blood coagulation, negative regulation of cell proliferation, negative regulation of cell growth, lipid homeostasis, regulation of lipid metabolic process, ornithine metabolic process, xenobiotic metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	313	SDPGKIKRLRSQVQVSLEDYI	AMPK_group	12740371	LTP	0.14		-	HOLI	0.28	1PZL	42.62%

Substrate:

Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)

Seq-ID:

P35568 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19010   INSR_HUMAN
MINT-68735   P85A_HUMAN
MINT-74551   EGFR_HUMAN
MINT-74553   ERBB2_HUMAN
MINT-3975430   1433S_HUMAN
MINT-6628637   LT_SV40
MINT-6793745   PTN1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphoinositide 3-kinase binding, protein kinase C binding, insulin-like growth factor receptor binding, insulin receptor binding, transmembrane receptor protein tyrosine kinase docking protein activity, SH2 domain binding	microsome, caveola, cytosol, insulin receptor complex, nucleus	negative regulation of insulin receptor signaling pathway, glucose homeostasis, positive regulation of insulin receptor signaling pathway, positive regulation of fatty acid beta-oxidation, phosphoinositide 3-kinase cascade, negative regulation of insulin secretion, positive regulation of glycogen biosynthetic process, insulin receptor signaling pathway, positive regulation of glucose import, positive regulation of phosphoinositide 3-kinase activity

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	794	ARHQHLRLSTSSGRLLYAATA	AMPK_group	20135346	LTP	1.00		-	-	0.65	-	-

Substrate:

Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)

Seq-ID:

P35569 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-58476   NUCL_MOUSE
MINT-6381887   P85A_MOUSE
MINT-6793439   PTN1_HUMAN
MINT-6794075   INSR_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphoinositide 3-kinase binding, insulin-like growth factor receptor binding, insulin receptor binding, SH2 domain binding	microsome, cytosol, nucleus	positive regulation of mesenchymal cell proliferation, positive regulation of cell migration, protein kinase B signaling cascade, mammary gland development, insulin receptor signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	789	ARHQHLRLSSSSGRLRYTATA	AMPK_group	11598104	LTP	0.03		-	-	0.75	-	-

Substrate:

Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)

Seq-ID:

P35570 [Rattus norvegicus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-45938   ITB2_HUMAN
MINT-45939   ITB3_HUMAN
MINT-60761   INSR_RAT
MINT-6762786   GRB2_HUMAN
MINT-6762811   PTN11_HUMAN
MINT-6762830   PTPRA_HUMAN
MINT-6762866   PTN1_HUMAN
MINT-6762880   P85A_HUMAN
MINT-6762904   CRK_HUMAN
MINT-6795115   INSR_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphoinositide 3-kinase binding, protein kinase C binding, insulin-like growth factor receptor binding, insulin-like growth factor receptor activity, insulin receptor binding, transmembrane receptor protein tyrosine kinase docking protein activity, SH2 domain binding	microsome, cytosol, insulin receptor complex, nucleus	negative regulation of insulin receptor signaling pathway, negative regulation of somatostatin secretion, positive regulation of insulin receptor signaling pathway, negative regulation of insulin secretion, protein heterooligomerization, insulin receptor signaling pathway, positive regulation of phosphoinositide 3-kinase activity, positive regulation of phosphorylation, positive regulation of glucagon secretion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	789	ARHQHLRLSSSSGRLRYTATA	AMPK_group	11598104	LTP	0.03		-	-	0.77	-	medium

Substrate:

KPNA2 (nuclear localization sequence binding, protein binding)

Seq-ID:

P52292 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-24920   IMB1_HUMAN
MINT-47857   IKBB_HUMAN
MINT-48975   RELB_HUMAN
MINT-62311   CHK2_HUMAN
MINT-6733247   LT_SV40

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
nuclear localization sequence binding, protein transporter activity, histone deacetylase binding	cytoplasm, nucleoplasm, nuclear pore	G2 phase of mitotic cell cycle, NLS-bearing substrate import into nucleus, regulation of DNA recombination, DNA metabolic process, interspecies interaction between organisms, M phase specific microtubule process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	105	QATQAARKLLSREKQPPIDNI	AMPK_group	15342649	LTP	1.00		-	-	0.51	-	-

Substrate:

Lipase hormone sensitive (Enzyme: Lipase)

Seq-ID:

P15304 [Rattus norvegicus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-7211789 KAPCA_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
rRNA primary transcript binding, acylglycerol lipase activity, RNA polymerase I transcription termination factor activity, hormone-sensitive lipase activity, protein binding	lipid particle, mitochondrion, caveola, cytosol, extracellular space, nucleus	triglyceride catabolic process, response to drug, female pregnancy, cholesterol metabolic process, transcription initiation from RNA polymerase I promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	865	RLTESMRRSVSEAALAQPEGL	AMPK_group	8506334	LTP	0.43		-	Abhydrolase_3	0.62	-	medium

Substrate:

Lipase hormone sensitive (Enzyme: Lipase)

Seq-ID:

P16386 [Bos taurus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
rRNA primary transcript binding, RNA polymerase I transcription termination factor activity, hormone-sensitive lipase activity, lipase activity	mitochondrion, caveola, cytosol, nucleus	lipid catabolic process, cholesterol metabolic process, transcription initiation from RNA polymerase I promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	10	KTEPMRRSVSEAALTQPEGP	AMPK_group	2537200	LTP	0.82		-	-	0.93	-	medium

Substrate:

Lipase hormone sensitive (Enzyme: Lipase)

Seq-ID:

Q05469 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
hormone-sensitive lipase activity, protein binding	caveola, cytosol	protein amino acid phosphorylation, cholesterol metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	855	PIAEPMRRSVSEAALAQPQGP	AMPK_group	16188906	LTP	0.43	MOD_PKA_2	-	Abhydrolase_3	0.72	-	medium
S	855	PIAEPMRRSVSEAALAQPQGP	AMPK_group	2537200	LTP	0.43	MOD_PKA_2	-	Abhydrolase_3	0.72	-	medium
S	855	PIAEPMRRSVSEAALAQPQGP	AMPK_group	15308678	LTP	0.43	MOD_PKA_2	-	Abhydrolase_3	0.72	-	medium

Substrate:

mTOR (Cell cycle control protein)

Seq-ID:

Q9JLN9 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, ATP binding	Golgi membrane, mitochondrial outer membrane, endoplasmic reticulum membrane, nucleus	negative regulation of macroautophagy, positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of lamellipodium assembly, response to amino acid stimulus, positive regulation of stress fiber assembly, negative regulation of cell size, germ cell development, positive regulation of actin filament polymerization, regulation of Rac GTPase activity, response to insulin stimulus, regulation of protein kinase activity, peptidyl-threonine phosphorylation, ruffle organization

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	2446	TKGNKRSRTRTDSYSAGQSVE	AMPK_group	14970221	LTP	0.11		-	PI3Kc	0.61	-	medium

Substrate:

Nitric-oxide synthase, endothelial (Nitric-oxide synthase, endothelial)

Seq-ID:

P29473 [Bos taurus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
NADP or NADPH binding, FAD binding, calmodulin binding, nitric-oxide synthase activity, FMN binding	caveola, cytoskeleton, Golgi apparatus	blood coagulation, oxidation reduction, anti-apoptosis, positive regulation of guanylate cyclase activity, arginine catabolic process, nitric oxide biosynthetic process, mitochondrion organization

Conservation:

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Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1179	QEVTSRIRTQSFSLQERHLRG	AMPK_group	11292821	LTP	0.12		-	-	0.41	-	-

Substrate:

Nitric-oxide synthase, endothelial (Nitric-oxide synthase, endothelial)

Seq-ID:

Q62600 [Rattus norvegicus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
NADP or NADPH binding, FAD binding, calmodulin binding, nitric-oxide synthase activity, FMN binding	caveola, cytoskeleton, nucleolus, Golgi apparatus, apical part of cell, soluble fraction	oxidation reduction, response to amino acid stimulus, response to hypoxia, response to organic cyclic substance, response to lead ion, aging, response to drug, response to estradiol stimulus, signal transduction, negative regulation of smooth muscle cell proliferation, response to cytokine stimulus, nitric oxide biosynthetic process, response to peptide hormone stimulus, response to hyperoxia, response to ethanol, response to lipoprotein stimulus

Conservation:

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Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	494	AKGTGITRKKTFKEVANAVKI	AMPK_group	10025949	LTP	0.05		-	-	0.32	-	low
S	1176	QEVTSRIRTQSFSLQERQLRG	AMPK_group	10025949	LTP	0.16		-	-	0.40	-	low

Substrate:

PFKFB3 (6-phosphofructo-2-kinase activity, identical protein binding)

Seq-ID:

Q16875 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
6-phosphofructo-2-kinase activity, fructose-2,6-bisphosphate 2-phosphatase activity, identical protein binding, ATP binding	cytosol	fructose 2,6-bisphosphate metabolic process

Conservation:

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Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	461	KGPNPLMRRNSVTPLASPEPT	AMPK_group	12065600	LTP	0.42		-	-	0.77	2AXN	82.79%

Substrate:

Phosphorylase b kinase alpha regulatory chain, skeletal muscle isoform (Enzyme: Phosphorylase)

Seq-ID:

P18688 [Oryctolagus cuniculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calmodulin binding, glucan 1,4-alpha-glucosidase activity	plasma membrane	glycogen metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1018	EIKQVEFRRLSISTESQPNGG	AMPK_group	2567185	LTP	0.45	MOD_PKA_1	-	PHK_AB	0.52	-	low
S	1020	KQVEFRRLSISTESQPNGGHS	AMPK_group	2567185	LTP	0.27		-	PHK_AB	0.54	-	low