List of substrates found:


Substrate: ATRIP (Required for checkpoint signaling after DNA damage)
Seq-ID: Q8WXE1 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-6978719   NEMO_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
protein binding		 nucleoplasm DNA repair,
DNA damage checkpoint,
DNA replication
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 68 DDLEELDTLASQALSQCPAAA ATR 15451423
LTP
1.00
 MOD_PIKK_1
 - -
0.62
 - medium
S 72 ELDTLASQALSQCPAAARDVS ATR 15451423
LTP
0.12
 MOD_PIKK_1
 - -
0.64
 - medium

Substrate: BRCA1 (Breast cancer type 1 susceptibility protein)
Seq-ID: P38398 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13705   JAK2_HUMAN
MINT-13786   ESR1_HUMAN
MINT-14573   SMC1A_HUMAN
MINT-16089   BRAP_HUMAN
MINT-16161   P53_HUMAN
MINT-16217   CREB1_HUMAN
MINT-16582   JAK1_HUMAN
MINT-19473   FACD2_HUMAN
MINT-19477   FANCA_HUMAN
MINT-25055   BARD1_HUMAN
MINT-77954   VE7_HPV16
MINT-2490745   H4_HUMAN
MINT-2791487   RD23B_HUMAN
MINT-5115454   FANCJ_HUMAN
MINT-7213847   ABL1_HUMAN
MINT-7250578   NCK1_HUMAN
MINT-7251658   P85A_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA binding,
identical protein binding,
ubiquitin protein ligase binding,
androgen receptor binding,
RNA binding,
transcription coactivator activity,
zinc ion binding,
tubulin binding,
ubiquitin-protein ligase activity		 ribonucleoprotein complex,
gamma-tubulin ring complex,
nucleoplasm,
BRCA1-BARD1 complex,
BRCA1-A complex		 positive regulation of gene-specific transcription from RNA polymerase II promoter,
negative regulation of centriole replication,
response to estrogen stimulus,
apoptosis,
chromosome segregation,
cellular response to indole-3-methanol,
fatty acid biosynthetic process,
regulation of transcription from RNA polymerase III promoter,
cell cycle,
postreplication repair,
G2/M transition DNA damage checkpoint,
positive regulation of protein ubiquitination,
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator,
negative regulation of transcription,
positive regulation of DNA repair,
negative regulation of fatty acid biosynthetic process,
androgen receptor signaling pathway,
regulation of cell proliferation,
protein K6-linked ubiquitination,
DNA damage response, signal transduction resulting in induction of apoptosis,
double-strand break repair via homologous recombination,
response to ionizing radiation,
protein autoubiquitination
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 1423 ELEAVLEQHGSQPSNSYPSII ATR 11278964
LTP
1.00
 MOD_PIKK_1
 - COIL
0.74
 --
S 1423 ELEAVLEQHGSQPSNSYPSII ATR 11114888
LTP
1.00
 MOD_PIKK_1
 - COIL
0.74
 --
S 1457 QSTSEKAVLTSQKSSEYPISQ ATR 11278964
LTP
1.00
 MOD_PIKK_1
 - -
0.74
 --
S 1524 SGSLQNRNYPSQEELIKVVDV ATR 11278964
LTP
1.00
 MOD_PIKK_1
 - -
0.62
 --

Substrate: CHK1 (Serine/threonine-protein kinase Chk1)
Seq-ID: O14757 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-51394   CSK2B_HUMAN
MINT-1958329   P53_HUMAN
MINT-4793746   RB_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
ATP binding,
protein binding		 condensed nuclear chromosome,
microtubule organizing center,
nucleoplasm		 protein amino acid phosphorylation,
regulation of cyclin-dependent protein kinase activity,
senescence,
DNA repair,
reciprocal meiotic recombination,
negative regulation of cell proliferation,
DNA damage checkpoint,
gamete generation,
DNA replication
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 317 SSEENVKYSSSQPEPRTGLSL ATR 11390642
LTP
0.96
 MOD_PIKK_1
 - -
0.56
 --
S 345 IDKLVQGISFSQPTCPDHMLL ATR 11390642
LTP
1.00
 MOD_PIKK_1
 SFN 14-3-3;
YWHAZ 14-3-3		 -
0.30
 --
S 345 IDKLVQGISFSQPTCPDHMLL ATR 10859164
LTP
1.00
 MOD_PIKK_1
 SFN 14-3-3;
YWHAZ 14-3-3		 -
0.30
 --
S 345 IDKLVQGISFSQPTCPDHMLL ATR 15533933
LTP
1.00
 MOD_PIKK_1
 SFN 14-3-3;
YWHAZ 14-3-3		 -
0.30
 --

Substrate: CREB (cAMP response element binding protein (CREB).)
Seq-ID: P16220 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-16217   BRCA1_HUMAN
MINT-56642   SGK1_HUMAN
MINT-63231   RECQ5_HUMAN
MINT-63483   VIME_HUMAN
MINT-63485   CHD3_HUMAN
MINT-4979977   CBP_HUMAN
MINT-5209851   EP300_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein dimerization activity,
transcription cofactor activity		 protein amino acid phosphorylation,
signal transduction,
interspecies interaction between organisms,
response to organic substance
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 121 SQESVDSVTDSQKRREILSRR ATR 15073328
LTP
1.00
 MOD_PIKK_1
 - pKID
0.73
 - low
S 121 SQESVDSVTDSQKRREILSRR ATR 16293623
LTP
1.00
 MOD_PIKK_1
 - pKID
0.73
 - low

Substrate: E2F-1 (Transcription factor)
Seq-ID: Q01094 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19370   TOPB1_HUMAN
MINT-73331   VE7_HPV16
MINT-4793665   RB_HUMAN
MINT-6804982   MCPH1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription corepressor activity,
sequence-specific DNA binding transcription factor activity		 mitochondrion transcription,
G1 phase of mitotic cell cycle,
apoptosis,
mRNA stabilization,
negative regulation of transcription from RNA polymerase II promoter,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 31 GAGALRLLDSSQIVIISAAQD ATR 11459832
LTP
0.14
 MOD_PIKK_1
 - -
0.33
 - medium

Substrate: Mdm2 (Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2. -) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2))
Seq-ID: Q00987 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-16320   ARRB2_HUMAN
MINT-58469   MED1_HUMAN
MINT-58599   CHK2_HUMAN
MINT-68739   HIPK2_HUMAN
MINT-1776635   RB_HUMAN
MINT-3376147   ARBK1_HUMAN
MINT-3391121   RL5_HUMAN
MINT-4793330   PML_HUMAN
MINT-6540837   PSME3_HUMAN
MINT-6540889   P53_HUMAN
MINT-6801697   DAXX_HUMAN
MINT-6823537   AKT1_HUMAN
MINT-6823574   PIM2_HUMAN
MINT-6823669   FKBP3_HUMAN
MINT-7013760   RYBP_HUMAN
MINT-7266353   PLK1_HUMAN
MINT-7718939   SNAI1_HUMAN
MINT-7904837   GORAB_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
identical protein binding,
p53 binding,
enzyme binding,
zinc ion binding,
basal transcription repressor activity,
ubiquitin-protein ligase activity		 plasma membrane,
endocytic vesicle membrane,
cytosol,
nucleolus,
nucleoplasm,
insoluble fraction,
protein complex		 positive regulation of cell proliferation,
protein complex assembly,
protein destabilization,
positive regulation of mitotic cell cycle,
negative regulation of DNA damage response, signal transduction by p53 class mediator,
positive regulation of proteasomal ubiquitin-dependent protein catabolic process,
protein ubiquitination involved in ubiquitin-dependent protein catabolic process,
interspecies interaction between organisms,
negative regulation of cell cycle arrest,
negative regulation of transcription from RNA polymerase II promoter,
protein localization in nucleus,
establishment of protein localization
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 407 PSTSSSIIYSSQEDVKEFERE ATR 14654783
LTP
1.00
 MOD_PIKK_1
 - -
0.53
 - medium

Valid HTML 4.01 Transitional