List of substrates found:


Substrate: CDK2 (Cell division protein kinase 2)
Seq-ID: P23437 [Xenopus laevis]
Download:fasta csv
Interaction Network(s): -
External Source(s):
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cyclin-dependent protein kinase activity,
ATP binding,
protein binding		 protein amino acid phosphorylation,
cell division,
mitosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 160 RAFGVPVRTFTHEVVTLWYRA CDK7 8393783
LTP
0.97
 - S_TKc
0.03
 - low

Substrate: CDK4 (cell division protein kinase 4 (EC 2.7.1.-) (PSK-J3) (CRK3) (from PhosphoBase))
Seq-ID: P11802 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-50417   MCM2_HUMAN
MINT-50418   CDN1A_HUMAN
MINT-50433   CCND1_HUMAN
MINT-50438   CCND3_HUMAN
MINT-3379718   CDN1B_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cyclin-dependent protein kinase activity,
ATP binding		 cytosol,
cyclin-dependent protein kinase holoenzyme complex		 positive regulation of fibroblast proliferation,
protein amino acid phosphorylation,
cell division,
G1/S transition of mitotic cell cycle,
response to drug
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 172 ARIYSYQMALTPVVVTLWYRA CDK7 8139570
LTP
1.00
 - S_TKc
0.03
 2W96 77.48%

Substrate: CDK4 (cell division protein kinase 4 (EC 2.7.1.-) (PSK-J3) (CRK3) (from PhosphoBase))
Seq-ID: P30285 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-7033488   CCND1_MOUSE
MINT-7033534   CCND1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cyclin-dependent protein kinase activity,
ATP binding		 transcription factor complex,
cyclin-dependent protein kinase holoenzyme complex		 protein amino acid phosphorylation,
regulation of cell cycle,
cell division,
signal transduction
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 172 ARIYSYQMALTPVVVTLWYRA CDK7 8139570
LTP
1.00
 - S_TKc
0.03
 - low

Substrate: CDK7 (cell division protein kinase 7 (EC 2.7.1.-) (p40MO15) (from PhosphoBase))
Seq-ID: P50613 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-7972052   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein C-terminus binding,
androgen receptor binding,
DNA-dependent ATPase activity,
cyclin-dependent protein kinase activity,
ATP binding,
transcription coactivator activity,
RNA polymerase II carboxy-terminal domain kinase activity		 mitochondrion,
holo TFIIH complex		 protein amino acid phosphorylation,
regulation of cyclin-dependent protein kinase activity,
cell division,
nucleotide-excision repair, DNA damage removal,
androgen receptor signaling pathway,
transcription initiation from RNA polymerase II promoter,
RNA elongation from RNA polymerase II promoter,
positive regulation of transcription from RNA polymerase II promoter,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 164 ADFGLAKSFGSPNRAYTHQVV CDK7 11113184
LTP
1.00
 MOD_CDK_SPxK_1
 - S_TKc
0.11
 1UA2 28.69%
T 170 KSFGSPNRAYTHQVVTRWYRA CDK7 11113184
LTP
1.00
 - S_TKc
0.14
 1UA2 40.41%

Substrate: Cell division control protein 2 (Cell division control protein 2 homolog (EC 2.7.1.-) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1))
Seq-ID: P06493 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-15829   1433S_HUMAN
MINT-73507   VE7_HPV16
MINT-77985   LT_SV40
MINT-1792672   TOPK_HUMAN
MINT-6166774   RGAP1_HUMAN
MINT-6549466   EF2K_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cyclin-dependent protein kinase activity,
ATP binding,
RNA polymerase II carboxy-terminal domain kinase activity		 midbody,
spindle microtubule,
cytosol,
nucleoplasm		 cell division,
positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle,
anti-apoptosis,
protein localization to kinetochore,
mitosis,
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 161 RAFGIPIRVYTHEVVTLWYRS CDK7 8344251
LTP
1.00
 - S_TKc
0.03
 - medium

Substrate: E2F-1 (Transcription factor)
Seq-ID: Q01094 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19370   TOPB1_HUMAN
MINT-73331   VE7_HPV16
MINT-4793665   RB_HUMAN
MINT-6804982   MCPH1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription corepressor activity,
sequence-specific DNA binding transcription factor activity		 mitochondrion transcription,
G1 phase of mitotic cell cycle,
apoptosis,
mRNA stabilization,
negative regulation of transcription from RNA polymerase II promoter,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 403 GLLPEEFISLSPPHEALDYHF CDK7 10428966
LTP
1.00
 - -
0.41
 - medium
T 433 DLFDCDFGDLTPLDF       CDK7 10428966
LTP
1.00
 - -
0.19
 - medium

Substrate: Estrogen receptor alpha (Estrogen receptor (ER) (Estradiol receptor) (ER-alpha); nuclear hormone receptor. )
Seq-ID: P03372 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-13786   BRCA1_HUMAN
MINT-50646   STA5A_HUMAN
MINT-50709   M3K1_HUMAN
MINT-5222241   NCOA1_HUMAN
MINT-6169667   EGFR_HUMAN
MINT-6614126   SMCA4_HUMAN
MINT-6614301   CHD3_HUMAN
MINT-6614361   MTA1_HUMAN
MINT-6614421   MTA2_HUMAN
MINT-6761899   PTN1_HUMAN
MINT-6761906   PTN6_HUMAN
MINT-7013584   PA1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
beta-catenin binding,
nitric-oxide synthase regulator activity,
estrogen response element binding,
steroid binding,
zinc ion binding,
sequence-specific DNA binding transcription factor activity,
estrogen receptor activity		 chromatin remodeling complex response to estradiol stimulus,
transcription, DNA-dependent,
regulation of transcription, DNA-dependent,
positive regulation of retinoic acid receptor signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 118 LMLLHPPPQLSPFLQPHGQQV CDK7 10949034
LTP
1.00
 MOD_ProDKin_1
 - Oest_recep
0.50
 --
S 118 LMLLHPPPQLSPFLQPHGQQV CDK7 15461668
LTP
1.00
 MOD_ProDKin_1
 - Oest_recep
0.50
 --
S 118 LMLLHPPPQLSPFLQPHGQQV CDK7 12118371
LTP
1.00
 MOD_ProDKin_1
 - Oest_recep
0.50
 --

Substrate: ICK (ATP binding, magnesium ion binding)
Seq-ID: Q9UPZ9 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-62019   SMAD1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
magnesium ion binding,
cyclin-dependent protein kinase activity,
ATP binding		 cytosol,
nucleus		 protein amino acid phosphorylation,
multicellular organismal development,
intracellular protein kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 157 AREIRSKPPYTDYVSTRWYRA CDK7 15988018
LTP
1.00
 - S_TKc
0.18
 - medium

Substrate: LASP1 (Cytoskeletal protein)
Seq-ID: Q14847 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-66300   TRP13_HUMAN
MINT-66313   PLS1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
ion transmembrane transporter activity,
SH3/SH2 adaptor activity,
zinc ion binding,
actin binding		 focal adhesion,
cortical actin cytoskeleton
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 146 GEGMEPERRDSQDGSSYRRPL CDK7 12571245
LTP
0.95
 MOD_PKA_1
 - -
0.90
 - low

Substrate: Octamer binding transcription factor 1 (Transcription factor)
Seq-ID: P14859 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-6803426   SP1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription repressor activity,
sequence-specific DNA binding,
sequence-specific DNA binding transcription factor activity,
protein binding		 transcription,
negative regulation of transcription, DNA-dependent
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 385 GLSRRRKKRTSIETNIRVALE CDK7 9368058
LTP
1.00
 MOD_PKA_1
 - HOX
0.43
 1HF0 90.16%

Substrate: p53 (Cellular tumor antigen p53)
Seq-ID: P04637 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13742   CHK2_HUMAN
MINT-15878   UBP7_HUMAN
MINT-16161   BRCA1_HUMAN
MINT-16977   PARP1_HUMAN
MINT-19990   PIN1_HUMAN
MINT-24859   ASPP2_HUMAN
MINT-45889   CEBPZ_HUMAN
MINT-49767   ATM_HUMAN
MINT-50577   SAE1_HUMAN
MINT-56524   SP1_HUMAN
MINT-58470   MED1_HUMAN
MINT-58672   HNRL1_HUMAN
MINT-60094   HIPK2_HUMAN
MINT-61312   MK08_HUMAN
MINT-61317   WWOX_HUMAN
MINT-62206   PP1A_HUMAN
MINT-63290   ARI2_HUMAN
MINT-63365   KITH_HUMAN
MINT-63497   ZNF24_HUMAN
MINT-63537   IF2B_HUMAN
MINT-63547   RAB4A_HUMAN
MINT-63559   SAT1_HUMAN
MINT-64119   STX5_HUMAN
MINT-64188   MD2BP_HUMAN
MINT-64748   K0087_HUMAN
MINT-65132   HSPB1_HUMAN
MINT-65272   MPH6_HUMAN
MINT-68565   BMX_HUMAN
MINT-74886   NPM_HUMAN
MINT-74925   1433Z_HUMAN
MINT-1795431   NMT1_HUMAN
MINT-1891378   CDN1A_HUMAN
MINT-1958329   CHK1_HUMAN
MINT-2634790   RGRF1_HUMAN
MINT-2858243   DVL2_HUMAN
MINT-2866927   SCAM1_HUMAN
MINT-3390028   KC1D_RAT
MINT-3979604   P53_MOUSE
MINT-4049689   NR4A1_HUMAN
MINT-4052116   SYVN1_HUMAN
MINT-4052873   GRP78_HUMAN
MINT-4302642   HS71L_HUMAN
MINT-4303978   XPO1_HUMAN
MINT-4329805   TOPRS_HUMAN
MINT-4793180   EGR1_HUMAN
MINT-4793253   GSK3B_HUMAN
MINT-4793489   PML_HUMAN
MINT-5114724   ZN363_HUMAN
MINT-5207405   HDAC8_HUMAN
MINT-6540866   PSME3_HUMAN
MINT-6540889   MDM2_HUMAN
MINT-6628692   LT_SV40
MINT-6665320   CBP_HUMAN
MINT-6701342   MAP1B_HUMAN
MINT-7013631   PA1_HUMAN
MINT-7013916   RYBP_HUMAN
MINT-7103733   ANDR_HUMAN
MINT-7144912   TOE1_HUMAN
MINT-7222784   FRAP_HUMAN
MINT-7263630   EP300_HUMAN
MINT-7266250   PLK1_HUMAN
MINT-7294020   FAK1_HUMAN
MINT-7295816   IKKB_HUMAN
MINT-7557644   GRP75_HUMAN
MINT-7711943   1433S_HUMAN
MINT-7717378   PHB_HUMAN
MINT-7718917   SNAI1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription activator activity,
protease binding,
DNA strand annealing activity,
chromatin binding,
copper ion binding,
ATP binding,
transcription factor binding,
chaperone binding,
zinc ion binding,
histone acetyltransferase binding,
promoter binding,
sequence-specific DNA binding transcription factor activity,
protein N-terminus binding,
protein heterodimerization activity,
protein phosphatase 2A binding,
protein kinase binding,
ubiquitin protein ligase binding		 nucleolus,
nuclear matrix,
insoluble fraction,
protein complex,
endoplasmic reticulum,
PML body,
mitochondrion		 positive regulation of gene-specific transcription from RNA polymerase II promoter,
senescence,
mitotic cell cycle G1/S DNA damage checkpoint,
cell cycle arrest,
regulation of mitochondrial membrane permeability,
response to gamma radiation,
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator,
response to tumor cell,
ER overload response,
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis,
interspecies interaction between organisms,
Ras protein signal transduction,
nucleotide-excision repair,
protein tetramerization,
cellular response to glucose starvation,
negative regulation of helicase activity,
negative regulation of cell growth,
base-excision repair,
activation of caspase activity by cytochrome c,
cell aging
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 33 WKLLPENNVLSPLPSQAMDDL CDK7 9372954
LTP
0.88
 MOD_GSK3_1
 PIN1 WW -
0.56
 --
S 371 GSRAHSSHLKSKKGQSTSRHK CDK7 9315650
LTP
0.66
 - -
0.88
 --
S 376 SSHLKSKKGQSTSRHKKLMFK CDK7 9315650
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.81
 --
S 378 HLKSKKGQSTSRHKKLMFKTE CDK7 9315650
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.82
 --
S 392 KLMFKTEGPDSD          CDK7 9315650
LTP
0.31
 - -
0.56
 --

Substrate: Retinoic acid receptor alpha (Nuclear hormone receptor family)
Seq-ID: P10276 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-24895   RXRA_HUMAN
MINT-25022   RXRA_MOUSE
MINT-2834436   NCOA3_HUMAN
MINT-2862542   UBE3A_HUMAN
MINT-5209864   NCOA1_HUMAN
MINT-5209905   MED1_HUMAN
MINT-7972514   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein heterodimerization activity,
retinoic acid binding,
retinoic acid receptor activity,
chromatin DNA binding,
protein domain specific binding,
transcription corepressor activity,
enzyme binding,
retinoic acid-responsive element binding,
transcription coactivator activity,
zinc ion binding,
receptor binding,
sequence-specific DNA binding transcription factor activity,
steroid hormone receptor activity		 cytoplasm,
cell surface,
nucleus		 negative regulation of granulocyte differentiation,
negative regulation of tumor necrosis factor production,
positive regulation of cell cycle,
response to estradiol stimulus,
positive regulation of gene-specific transcription,
positive regulation of interleukin-5 production,
positive regulation of binding,
cellular response to estrogen stimulus,
estrogen receptor signaling pathway,
cellular response to retinoic acid,
negative regulation of interferon-gamma production,
positive regulation of transcription from RNA polymerase II promoter,
apoptotic cell clearance,
positive regulation of interleukin-13 production,
negative regulation of gene-specific transcription,
positive regulation of interleukin-4 production,
positive regulation of cell proliferation,
protein amino acid phosphorylation,
transcription,
positive regulation of T-helper 2 cell differentiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 77 SSEEIVPSPPSPPPLPRIYKP CDK7 9230306
LTP
0.97
 - -
0.48
 --

Valid HTML 4.01 Transitional