Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

Substrate:

ATRIP (Required for checkpoint signaling after DNA damage)

Seq-ID:

Q8WXE1 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-6978719 NEMO_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, protein binding	nucleoplasm	DNA repair, DNA damage checkpoint, DNA replication

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	224	KLAAPSVSHVSPRKNPSVVIK	CDK2	17638878	LTP	1.00	MOD_CDK_SPxK_1	-	-	0.58	-	medium
S	239	PSVVIKPEACSPQFGKTSFPT	CDK2	17638878	LTP	1.00		-	-	0.47	-	medium

Substrate:

B-Myb (Transcription factor)

Seq-ID:

P10244 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-4053806   E2F3_HUMAN
MINT-4054286   HDAC2_HUMAN
MINT-4301520   LIN9_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding transcription factor activity	nucleus	transcription

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	444	DSCNSLTPKSTPVKTLPFSPS	CDK2	9840932	LTP	0.97	MOD_CDK_SPxK_1	-	-	0.52	-	medium
T	487	PVCSQKVVVTTPLHRDKTPLH	CDK2	9840932	LTP	0.89		-	Cmyb_C	0.59	-	medium
T	494	VVTTPLHRDKTPLHQKHAAFV	CDK2	9840932	LTP	0.87		-	Cmyb_C	0.60	-	medium
S	577	KQKRKPGLRRSPIKKVRKSLA	CDK2	9840932	LTP	0.50	MOD_CDK_SPxK_1	-	Cmyb_C	0.63	-	medium

Substrate:

B-Myb (Transcription factor)

Seq-ID:

P48972 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
DNA binding	nucleus	transcription, regulation of transcription

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	267	PVPADLGEVRTPEPPESLKRE	CDK2	10593981	LTP	0.41		-	-	0.79	-	medium
S	283	SLKREYQEFSSPETSLPYKWV	CDK2	10593981	LTP	0.66		-	-	0.46	-	medium
S	396	RSSRGELIPISPSTEFGGSGI	CDK2	10593981	LTP	0.91		-	-	0.59	-	medium
T	408	STEFGGSGIGTPPSVLKRQKK	CDK2	10593981	LTP	0.92		-	-	0.66	-	medium
T	443	LSFLDSCNSLTPKSTPVKTLP	CDK2	10095772	LTP	0.92		-	-	0.48	-	medium
T	447	DSCNSLTPKSTPVKTLPFSPS	CDK2	9840932	LTP	0.93	MOD_CDK_SPxK_1	-	-	0.54	-	medium
T	447	DSCNSLTPKSTPVKTLPFSPS	CDK2	11264176	LTP	0.93	MOD_CDK_SPxK_1	-	-	0.54	-	medium
S	455	KSTPVKTLPFSPSQFLNFWNK	CDK2	10593981	LTP	0.87		-	Cmyb_C	0.41	-	medium
T	490	PVCSQKVVVTTPLHRDKTPLH	CDK2	9840932	LTP	0.88		-	Cmyb_C	0.58	-	medium
T	490	PVCSQKVVVTTPLHRDKTPLH	CDK2	11264176	LTP	0.88		-	Cmyb_C	0.58	-	medium
T	497	VVTTPLHRDKTPLHQKYPSSE	CDK2	9840932	LTP	0.84		-	Cmyb_C	0.66	-	medium
T	497	VVTTPLHRDKTPLHQKYPSSE	CDK2	10593981	LTP	0.84		-	Cmyb_C	0.66	-	medium
T	497	VVTTPLHRDKTPLHQKYPSSE	CDK2	11264176	LTP	0.84		-	Cmyb_C	0.66	-	medium
T	519	LPDQKYSMDNTPHTPTPFKNA	CDK2	10593981	LTP	0.87		-	Cmyb_C	0.73	-	medium
T	522	QKYSMDNTPHTPTPFKNALEK	CDK2	10593981	LTP	1.00	MOD_CDK_SPxK_1	-	Cmyb_C	0.71	-	medium
T	524	YSMDNTPHTPTPFKNALEKYG	CDK2	10095772	LTP	1.00	MOD_CDK_SPxK_1	-	Cmyb_C	0.70	-	medium
S	581	KQKRKPGLRRSPIKKVRKSLA	CDK2	9840932	LTP	0.47	MOD_CDK_SPxK_1	-	Cmyb_C	0.68	-	medium
S	581	KQKRKPGLRRSPIKKVRKSLA	CDK2	10593981	LTP	0.47	MOD_CDK_SPxK_1	-	Cmyb_C	0.68	-	medium
S	581	KQKRKPGLRRSPIKKVRKSLA	CDK2	11264176	LTP	0.47	MOD_CDK_SPxK_1	-	Cmyb_C	0.68	-	medium

Substrate:

BRCA1 (Breast cancer type 1 susceptibility protein)

Seq-ID:

P38398 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13705   JAK2_HUMAN
MINT-13786   ESR1_HUMAN
MINT-14573   SMC1A_HUMAN
MINT-16089   BRAP_HUMAN
MINT-16161   P53_HUMAN
MINT-16217   CREB1_HUMAN
MINT-16582   JAK1_HUMAN
MINT-19473   FACD2_HUMAN
MINT-19477   FANCA_HUMAN
MINT-25055   BARD1_HUMAN
MINT-77954   VE7_HPV16
MINT-2490745   H4_HUMAN
MINT-2791487   RD23B_HUMAN
MINT-5115454   FANCJ_HUMAN
MINT-7213847   ABL1_HUMAN
MINT-7250578   NCK1_HUMAN
MINT-7251658   P85A_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
DNA binding, identical protein binding, ubiquitin protein ligase binding, androgen receptor binding, RNA binding, transcription coactivator activity, zinc ion binding, tubulin binding, ubiquitin-protein ligase activity	ribonucleoprotein complex, gamma-tubulin ring complex, nucleoplasm, BRCA1-BARD1 complex, BRCA1-A complex	positive regulation of gene-specific transcription from RNA polymerase II promoter, negative regulation of centriole replication, response to estrogen stimulus, apoptosis, chromosome segregation, cellular response to indole-3-methanol, fatty acid biosynthetic process, regulation of transcription from RNA polymerase III promoter, cell cycle, postreplication repair, G2/M transition DNA damage checkpoint, positive regulation of protein ubiquitination, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, negative regulation of transcription, positive regulation of DNA repair, negative regulation of fatty acid biosynthetic process, androgen receptor signaling pathway, regulation of cell proliferation, protein K6-linked ubiquitination, DNA damage response, signal transduction resulting in induction of apoptosis, double-strand break repair via homologous recombination, response to ionizing radiation, protein autoubiquitination

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1497	KNKEPGVERSSPSKCPSLDDR	CDK2	10373534	LTP	1.00	MOD_CDK_SPxK_1	-	-	0.76	-	-

Substrate:

CDK7 (cell division protein kinase 7 (EC 2.7.1.-) (p40MO15) (from PhosphoBase))

Seq-ID:

P50613 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-7972052 DLG4_RAT

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein C-terminus binding, androgen receptor binding, DNA-dependent ATPase activity, cyclin-dependent protein kinase activity, ATP binding, transcription coactivator activity, RNA polymerase II carboxy-terminal domain kinase activity	mitochondrion, holo TFIIH complex	protein amino acid phosphorylation, regulation of cyclin-dependent protein kinase activity, cell division, nucleotide-excision repair, DNA damage removal, androgen receptor signaling pathway, transcription initiation from RNA polymerase II promoter, RNA elongation from RNA polymerase II promoter, positive regulation of transcription from RNA polymerase II promoter, cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	164	ADFGLAKSFGSPNRAYTHQVV	CDK2	11113184	LTP	1.00	MOD_CDK_SPxK_1	-	S_TKc	0.11	1UA2	28.69%
T	170	KSFGSPNRAYTHQVVTRWYRA	CDK2	11113184	LTP	1.00		-	S_TKc	0.14	1UA2	40.41%

Substrate:

Cell division control protein 6 homolog (Cell cycle control protein)

Seq-ID:

Q99741 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-50400   MCM10_HUMAN
MINT-50401   MCM2_HUMAN
MINT-50402   MCM3_HUMAN
MINT-50403   ORC1_HUMAN
MINT-50404   ORC2_HUMAN
MINT-50405   ORC3_HUMAN
MINT-50406   CD2A1_HUMAN
MINT-50407   CDN1A_HUMAN
MINT-50423   CDT1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
nucleoside-triphosphatase activity, ATP binding, protein binding	cytosol, nucleoplasm	regulation of cyclin-dependent protein kinase activity, cell division, negative regulation of cell proliferation, traversing start control point of mitotic cell cycle, DNA replication checkpoint, mitosis, DNA replication

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	54	CSPRVKALPLSPRKRLGDDNL	CDK2	9889196	LTP	1.00	MOD_CDK_SPxK_1	-	-	0.61	-	medium
S	54	CSPRVKALPLSPRKRLGDDNL	CDK2	10339564	LTP	1.00	MOD_CDK_SPxK_1	-	-	0.61	-	medium
S	74	LCNTPHLPPCSPPKQGKKENG	CDK2	9889196	LTP	0.28	MOD_CDK_SPxK_1	-	-	0.82	-	medium
S	74	LCNTPHLPPCSPPKQGKKENG	CDK2	10339564	LTP	0.28	MOD_CDK_SPxK_1	-	-	0.82	-	medium
S	106	LVFDNQLTIKSPSKRELAKVH	CDK2	10339564	LTP	0.16	MOD_CDK_SPxK_1	-	-	0.53	-	medium

Substrate:

Coilin (RNA binding protein)

Seq-ID:

P38432 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-2856455   ACTN4_HUMAN
MINT-2856571   ACTN1_HUMAN
MINT-2856747   ACTN2_HUMAN
MINT-2857230   BYST_HUMAN
MINT-2857268   C1QBP_HUMAN
MINT-2857838   CSK2B_HUMAN
MINT-2859824   ANM1_HUMAN
MINT-2860236   IMA3_HUMAN
MINT-2861993   PSA1_HUMAN
MINT-2863455   TAF9_HUMAN
MINT-2864784   ATX1_HUMAN
MINT-2864955   MD1L1_HUMAN
MINT-2865160   DHX16_HUMAN
MINT-2865791   DNJA3_HUMAN
MINT-2866883   FXR2_HUMAN
MINT-2867369   SART3_HUMAN
MINT-2868160   PSME3_HUMAN
MINT-2871676   PKHG4_HUMAN
MINT-2875116   NTKL_HUMAN
MINT-2875196   KLDC5_HUMAN
MINT-2875723   TSYL2_HUMAN
MINT-2876052   KLC2_HUMAN
MINT-2876547   CEP76_HUMAN
MINT-2877853   KLC4_HUMAN
MINT-2878132   TGS1_HUMAN
MINT-7041203   HABP4_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein C-terminus binding	Cajal body, nucleolus

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	184	GDDNEEAKRKSPKKKEKCEYK	CDK2	11102515	LTP	0.29	MOD_CDK_SPxK_1	-	-	0.65	-	medium

Substrate:

Cyclin dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1))

Seq-ID:

P46527 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-17680   AKT1_HUMAN
MINT-17889   1433T_HUMAN
MINT-63858   GDIR1_HUMAN
MINT-1779946   MCM7_HUMAN
MINT-3379700   CDK2_HUMAN
MINT-3379718   CDK4_HUMAN
MINT-7219650   GRB2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cyclin-dependent protein kinase inhibitor activity, transforming growth factor beta receptor, cytoplasmic mediator activity, protein binding	cytosol, nucleus	negative regulation of kinase activity, regulation of cyclin-dependent protein kinase activity, negative regulation of cell proliferation, negative regulation of cell growth, cell cycle arrest, G1/S transition of mitotic cell cycle, autophagic cell death, cellular response to lithium ion, induction of apoptosis, negative regulation of gene-specific transcription

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	187	GSPNAGSVEQTPKKPGLRRRQ	CDK2	12700233	LTP	1.00	MOD_CDK_SPxK_1	-	-	0.94	-	-

Substrate:

Cyclin E1 (Cell cycle control protein)

Seq-ID:

P24864 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14269   FBXW7_HUMAN
MINT-1788668   FOXM1_HUMAN
MINT-2635177   CDN1A_HUMAN
MINT-2983466   CDK2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
androgen receptor binding, transcription coactivator activity	cytosol, nucleoplasm	cell division, positive regulation of transcription, DNA-dependent, G1/S transition of mitotic cell cycle, androgen receptor signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	395	RASPLPSGLLTPPQSGKKQSS	CDK2	14536078	LTP	1.00	MOD_GSK3_1	-	-	0.77	-	-
S	399	LPSGLLTPPQSGKKQSSGPEM	CDK2	14536078	LTP	1.00		-	-	0.78	-	-

Substrate:

DNA replication licensing factor MCM4 (DNA binding protein)

Seq-ID:

P33991 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-2984401 SSRP1_HUMAN
MINT-2984454 SP16H_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
ATP binding, protein binding	nucleoplasm	transcription, regulation of transcription, DNA-dependent DNA replication initiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	32	QTPRSEDARSSPSQRRRGEDS	CDK2	12714602	LTP	0.85		-	-	0.98	-	medium
S	54	STGELQPMPTSPGVDLQSPAA	CDK2	12714602	LTP	0.15		-	-	0.93	-	medium
T	110	EGTPRSGVRGTPVRQRPDLGS	CDK2	12714602	LTP	0.18	MOD_CDK_SPxK_1	-	-	0.84	-	medium

Substrate:

DNA replication licensing factor MCM4 (DNA binding protein)

Seq-ID:

P49717 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
nucleoside-triphosphatase activity, ATP binding, single-stranded DNA binding, protein binding	nucleus	transcription, regulation of transcription, DNA unwinding involved in replication, DNA-dependent DNA replication initiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	3	MSSPASTPSRRSS	CDK2	11454864	LTP	0.62	-	-	0.82	-	medium
T	19	SRRSSRRGRVTPTQSLRSEES	CDK2	11454864	LTP	0.10	-	-	0.93	-	medium
T	19	SRRSSRRGRVTPTQSLRSEES	CDK2	16519687	LTP	0.10	-	-	0.93	-	medium
S	53	STGELLPMPTSPGADLQSPPA	CDK2	11454864	LTP	0.23	-	-	0.93	-	medium

Substrate:

DNA-binding protein inhibitor ID-2 (Transcription regulatory protein)

Seq-ID:

Q02363 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-64030 CA103_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription repressor activity, protein binding	nucleus	negative regulation of transcription factor activity

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	5	MKAFSPVRSVRKNSL	CDK2	9029153	LTP	0.89	MOD_CDK_SPxK_1	-	-	0.44	-	medium

Substrate:

DNA-binding protein inhibitor ID-3 (Transcription regulatory protein)

Seq-ID:

Q02535 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription corepressor activity	nucleus	negative regulation of transcription factor activity

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	5	MKALSPVRGCYEAVC	CDK2	9372912	LTP	-	MOD_CDK_SPxK_1	-	-	0.09	-	medium

Substrate:

E2F5 (Transcription factor)

Seq-ID:

Q61502 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding transcription factor activity, protein binding	cytoplasm, transcription factor complex, nuclear envelope	regulation of cell cycle, transcription, organ morphogenesis, G1/S transition of mitotic cell cycle, regulation of transcription, DNA-dependent

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	251	QPSSQSSTSVTPQKSTMAAQN	CDK2	10783242	LTP	0.06	MOD_CDK_SPxK_1	-	-	0.78	-	medium

Substrate:

Forkhead box protein M1 (Transcription factor)

Seq-ID:

Q08050-2 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-73149 VE7_HPV16

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription factor activity, protein binding	nucleus	positive regulation of cell proliferation, transcription from RNA polymerase II promoter, regulation of cell growth, transcription, regulation of cell cycle arrest, cell cycle, regulation of Ras protein signal transduction, negative regulation of stress-activated MAPK cascade, negative regulation of cell aging, regulation of cell proliferation, regulation of transcription, DNA-dependent, regulation of oxygen and reactive oxygen species metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	596	PIKETLPISSTPSKSVLPRTP	CDK2	15024056	LTP	1.00	MOD_CDK_SPxK_1	-	-	0.69	-	medium

Substrate:

HIRA (transcription corepressor activity, transcription factor activity)

Seq-ID:

P54198 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription corepressor activity, chromatin binding, sequence-specific DNA binding transcription factor activity		chromatin modification, transcription, regulation of transcription from RNA polymerase II promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	555	PAALSPSVLTTPSKIEPMKAF	CDK2	11238922	LTP	0.49	MOD_CDK_SPxK_1	-	-	0.58	-	medium

Substrate:

Mcm3ap (Cell cycle control protein)

Seq-ID:

Q9WUU9 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

Molecular Function	Cellular Component	Biological Process
	nucleus

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	502	VVIFWHKKKISPSKKLFPLKE	CDK2	11526238	LTP	1.00	MOD_CDK_SPxK_1	-	-	0.17	-	medium

Substrate:

Mdm2 (Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2. -) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2))

Seq-ID:

P23804 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19799 ARRB1_HUMAN
MINT-7266318 PLK1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
p53 binding, ubiquitin-protein ligase activity	cytoplasm, nucleolus	traversing start control point of mitotic cell cycle, positive regulation of cell cycle

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	216	SSSSSSESTETPSHQDLDDGV	CDK2	11359766	LTP	0.08		-	-	0.90	-	medium

Substrate:

Myogenic factor 3 (Transcription factor)

Seq-ID:

P10085 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-50074 CREB1_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription activator activity, RNA polymerase II transcription factor activity, enhancer binding, transcription factor binding	transcription factor complex	transcription, regulation of alternative nuclear mRNA splicing, via spliceosome, myoblast cell fate determination, positive regulation of skeletal muscle tissue regeneration, striated muscle cell differentiation, skeletal muscle tissue development, positive regulation of transcription from RNA polymerase II promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	200	EHYSGDSDASSPRSNCSDGMM	CDK2	10082583	LTP	1.00		-	-	0.76	-	medium
S	200	EHYSGDSDASSPRSNCSDGMM	CDK2	10942602	LTP	1.00		-	-	0.76	-	medium

Substrate:

p21 (Cyclin-dependent kinase inhibitor 1 (p21))

Seq-ID:

P38936 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-50392   CC45L_HUMAN
MINT-50407   CDC6_HUMAN
MINT-50418   CDK4_HUMAN
MINT-50421   CDK6_HUMAN
MINT-50432   CCNB2_HUMAN
MINT-50437   CCND1_HUMAN
MINT-50441   CCND3_HUMAN
MINT-50445   GEMI_HUMAN
MINT-50660   CCNB1_HUMAN
MINT-73322   VE7_HPV16
MINT-73323   CDK2_HUMAN
MINT-1774121   SKP2_HUMAN
MINT-1780042   MCM7_HUMAN
MINT-1891378   P53_HUMAN
MINT-2635177   CCNE1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cyclin-dependent protein kinase inhibitor activity, metal ion binding	cytosol, cyclin-dependent protein kinase holoenzyme complex, nucleoplasm, PCNA-p21 complex	cellular response to extracellular stimulus, positive regulation of fibroblast proliferation, senescence, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, negative regulation of cell proliferation, negative regulation of cell growth, cell cycle arrest, G1/S transition of mitotic cell cycle, induction of apoptosis by intracellular signals, Ras protein signal transduction, G2/M transition of mitotic cell cycle

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	130	VPRSGEQAEGSPGGPGDSQGR	CDK2	12730199	LTP	0.03	MOD_ProDKin_1	-	-	0.91	-	medium
S	130	VPRSGEQAEGSPGGPGDSQGR	CDK2	15964852	LTP	0.03	MOD_ProDKin_1	-	-	0.91	-	medium

Substrate:

p73 (Member of the TP53 family. It participates in the apoptotic response to DNA damage)

Seq-ID:

O15350 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13681   EP300_HUMAN
MINT-45880   ASPP1_HUMAN
MINT-45891   CEBPZ_HUMAN
MINT-60132   WWOX_HUMAN
MINT-3389173   ITCH_HUMAN
MINT-7309761   ABL1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription activator activity, transcription factor binding, zinc ion binding, promoter binding, sequence-specific DNA binding transcription factor activity, protein binding	nucleus	mismatch repair, transcription, negative regulation of cell growth, positive regulation of gene-specific transcription, response to tumor cell, DNA damage response, signal transduction resulting in induction of apoptosis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	86	SSRAASASPYTPEHAASVPTH	CDK2	12676926	LTP	0.17		-	-	0.65	-	medium

Substrate:

Progesterone receptor (Progesterone receptor (PR))

Seq-ID:

P06401 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-4788079 JDP2_HUMAN
MINT-4788120 NCOR2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
steroid binding, zinc ion binding, receptor binding, sequence-specific DNA binding transcription factor activity, protein binding, steroid hormone receptor activity	cytoplasm, nucleus	transcription, cell-cell signaling

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	162	PAAPATQRVLSPLMSRSGCKV	CDK2	11110801	LTP	0.52		-	Prog_receptor	0.69	-	medium
S	162	PAAPATQRVLSPLMSRSGCKV	CDK2	9171245	LTP	0.52		-	Prog_receptor	0.69	-	medium
S	190	AAHKVLPRGLSPARQLLLPAS	CDK2	11110801	LTP	1.00	MOD_CDK_SPxK_1	-	Prog_receptor	0.59	-	medium
S	190	AAHKVLPRGLSPARQLLLPAS	CDK2	9171245	LTP	1.00	MOD_CDK_SPxK_1	-	Prog_receptor	0.59	-	medium
S	213	PHWSGAPVKPSPQAAAVEVEE	CDK2	11110801	LTP	0.68		-	Prog_receptor	0.77	-	medium
S	400	EEEGAEASARSPRSYLVAGAN	CDK2	11110801	LTP	0.59		-	Prog_receptor	0.63	-	medium
S	400	EEEGAEASARSPRSYLVAGAN	CDK2	9171245	LTP	0.59		-	Prog_receptor	0.63	-	medium
S	676	SQALSQRFTFSPGQDIQLIPP	CDK2	11110801	LTP	1.00		-	-	0.19	-	medium

Substrate:

Retinoblastoma like 2 (Cell cycle control protein)

Seq-ID:

Q08999 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-16160   RBBP8_HUMAN
MINT-68815   VE7_HPV16
MINT-6665139   E1A_ADE05

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
DNA binding, protein binding		chromatin modification, transcription, regulation of transcription, cell cycle, regulation of lipid kinase activity

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	413	LTGVRYIKENSPCVTPVSTAT	CDK2	11157749	LTP	0.05		-	-	0.38	-	medium
T	417	RYIKENSPCVTPVSTATHSLS	CDK2	11157749	LTP	1.00		-	RB_A	0.40	-	medium
S	639	ERADEICIAGSPLTPRRVTEV	CDK2	11157749	LTP	1.00	MOD_CDK_SPxK_1	-	-	0.45	-	medium
T	642	DEICIAGSPLTPRRVTEVRAD	CDK2	11157749	LTP	0.21	MOD_CDK_SPxK_1	-	-	0.46	-	medium
S	662	DTGGLGRSITSPTTLYDRYSS	CDK2	11157749	LTP	0.24		-	-	0.57	-	medium
S	688	TRRRLFVENDSPSDGGTPGRM	CDK2	11157749	LTP	0.20		-	-	0.86	-	medium
T	694	VENDSPSDGGTPGRMPPQPLV	CDK2	11157749	LTP	0.23	MOD_CDK_SPxK_1	-	-	0.89	-	medium
S	952	GSSDSRSHQNSPTELNKDRTS	CDK2	11157749	LTP	0.20		-	RB_B	0.89	-	medium
S	1044	LSPYPFVRTGSPRRIQLSQNH	CDK2	11157749	LTP	0.28	MOD_CDK_SPxK_1	-	-	0.63	-	medium
S	1068	ISPHKNETMLSPREKIFYYFS	CDK2	11157749	LTP	0.20		-	-	0.40	-	medium
S	1080	REKIFYYFSNSPSKRLREINS	CDK2	11157749	LTP	1.00	MOD_CDK_SPxK_1	-	-	0.34	-	medium
T	1097	EINSMIRTGETPTKKRGILLE	CDK2	11157749	LTP	0.18	MOD_CDK_SPxK_1	-	-	0.56	-	medium
S	1112	RGILLEDGSESPAKRICPENH	CDK2	11157749	LTP	1.00	MOD_CDK_SPxK_1	-	-	0.54	-	medium

Substrate:

SMAD3 (Transcription regulatory protein)

Seq-ID:

P84022 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14023   CEBPB_HUMAN
MINT-15105   MED15_HUMAN
MINT-19375   LAP2_MOUSE
MINT-51235   SRBP2_HUMAN
MINT-51239   41_HUMAN
MINT-51243   MYO5B_HUMAN
MINT-51244   TPM3_HUMAN
MINT-51245   CRK_HUMAN
MINT-51247   GT2D1_HUMAN
MINT-51248   LMNA_HUMAN
MINT-51249   VIME_HUMAN
MINT-51250   SF3A1_HUMAN
MINT-51251   ACTB_HUMAN
MINT-51253   PYGL_HUMAN
MINT-61695   MLL4_HUMAN
MINT-61696   KU70_HUMAN
MINT-61697   KDM2A_HUMAN
MINT-61703   GMEB1_HUMAN
MINT-61705   PCDH1_HUMAN
MINT-61707   ZEB2_HUMAN
MINT-61710   RANB9_HUMAN
MINT-61711   MCM3A_HUMAN
MINT-61716   MTF2_HUMAN
MINT-61717   CFDP1_HUMAN
MINT-61720   SP130_HUMAN
MINT-61721   NCOA6_HUMAN
MINT-61723   K1267_HUMAN
MINT-61726   ZEP1_HUMAN
MINT-61732   GI24_HUMAN
MINT-61733   FLNA_HUMAN
MINT-61734   RLA0_HUMAN
MINT-61735   RU17_HUMAN
MINT-61737   TGM2_HUMAN
MINT-61949   SMAD4_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transforming growth factor beta receptor binding, protein homodimerization activity, R-SMAD binding, protein kinase binding, co-SMAD binding, ubiquitin protein ligase binding, transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity, beta-catenin binding, transcription factor binding, promoter binding, sequence-specific DNA binding transcription factor activity	nuclear inner membrane, receptor complex, cytosol	protein stabilization, negative regulation of cell growth, SMAD protein complex assembly, cell cycle arrest, positive regulation of canonical Wnt receptor signaling pathway, positive regulation of catenin protein nuclear translocation, activation of caspase activity, immune response, regulation of transforming growth factor beta receptor signaling pathway, transport, positive regulation of transcription factor import into nucleus, regulation of transforming growth factor-beta2 production, transforming growth factor beta receptor signaling pathway, negative regulation of mitotic cell cycle, wound healing, induction of apoptosis, positive regulation of epithelial to mesenchymal transition, cell-cell junction organization, negative regulation of protein amino acid phosphorylation, primary microRNA processing, transcription, evasion of host defenses by virus, negative regulation of protein catabolic process, response to hypoxia

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	8	MSSILPFTPPIVKRLLGW	CDK2	15520018	LTP	1.00		-	-	0.17	1OZJ	32.19%
T	179	GIEPQSNIPETPPPGYLSEDG	CDK2	15241418	LTP	0.57	MOD_ProDKin_1	-	-	0.80	-	-
S	213	GSPNLSPNPMSPAHNNLDLQP	CDK2	15241418	LTP	0.82	MOD_ProDKin_1	-	-	0.68	-	-

Substrate:

Splicing factor 3B subunit 1 (Ribonucleoprotein)

Seq-ID:

O75533 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-61826   SMAD5_HUMAN
MINT-61997   SMAD1_HUMAN
MINT-62081   SMAD9_HUMAN
MINT-62164   SNIP1_HUMAN
MINT-72780   WWOX_HUMAN
MINT-73049   WBP4_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein binding	spliceosomal complex, nuclear speck	nuclear mRNA splicing, via spliceosome

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	244	ETPGRAKGSETPGATPGSKIW	CDK2	12105215	LTP	0.59	PPP1R8 FHA	-	0.93	-	medium
T	248	RAKGSETPGATPGSKIWDPTP	CDK2	12105215	LTP	0.44	PPP1R8 FHA	-	0.94	-	medium
T	313	TPGHGSGWAETPRTDRGGDSI	CDK2	12105215	LTP	0.79	PPP1R8 FHA	-	0.94	-	medium

Substrate:

TK1 (thymidine kinase activity)

Seq-ID:

P04183 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-63364   G3P_HUMAN
MINT-63365   P53_HUMAN
MINT-63367   TLE1_HUMAN
MINT-63371   SETB1_HUMAN
MINT-63375   CC90B_HUMAN
MINT-63376   CA103_HUMAN
MINT-3296457   1433Z_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
ATP binding, thymidine kinase activity	cytoplasm	DNA replication

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	13	CINLPTVLPGSPSKTRGQIQV	CDK2	9575153	LTP	0.86	MOD_CDK_SPxK_1	-	-	0.28	-	-

Substrate:

TTK (Dual specificity protein kinase)

Seq-ID:

P33981-1 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, identical protein binding, ATP binding, protein tyrosine kinase activity	spindle	positive regulation of cell proliferation, protein amino acid phosphorylation, positive regulation of pathway-restricted SMAD protein phosphorylation, mitotic spindle organization, mitotic cell cycle spindle assembly checkpoint

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	468	TLDDYMSCFRTPVVKNDFPPA	CDK2	17804818	LTP	-		-	-	0.31	-	-

Substrate:

UBF-1 (Transcription factor)

Seq-ID:

P17480 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-62331   ZMYM2_HUMAN
MINT-63514   SCG1_HUMAN
MINT-1894291   FBRL_HUMAN
MINT-4543985   SET_HUMAN
MINT-7720853   CEBPA_HUMAN
MINT-7971422   DLG4_RAT

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
DNA binding, RNA polymerase I transcription factor activity, protein binding	nucleolus, nucleoplasm	transcription, positive regulation of transcription from RNA polymerase I promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	389	MLNINKKQATSPASKKPAQEG	CDK2	11698641	LTP	0.85		-	-	0.81	-	-

Substrate:

UBF-1 (Transcription factor)

Seq-ID:

P25976 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-4652979 CCNB2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
DNA binding, protein binding	nucleolus	transcription, positive regulation of transcription from RNA polymerase I promoter, chromatin silencing at rDNA

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	389	MLNINKKQTTSPASKKPSQEG	CDK2	11698641	LTP	0.85		-	-	0.84	-	-

Substrate:

Ubiquitin-conjugating enzyme E2 A (Ubiquitin proteasome system protein)

Seq-ID:

P49459 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
ubiquitin protein ligase binding, ATP binding, ubiquitin-protein ligase activity		positive regulation of cell proliferation, regulation of protein metabolic process, response to UV, protein autoubiquitination, histone H2A ubiquitination, postreplication repair, protein K11-linked ubiquitination, protein K48-linked ubiquitination, ubiquitin-dependent protein catabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	120	QSLLDEPNPNSPANSQAAQLY	CDK2	11953320	LTP	1.00		-	UBCc	0.63	-	medium