List of substrates found:


Substrate: BRCA1 (Breast cancer type 1 susceptibility protein)
Seq-ID: P38398 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13705   JAK2_HUMAN
MINT-13786   ESR1_HUMAN
MINT-14573   SMC1A_HUMAN
MINT-16089   BRAP_HUMAN
MINT-16161   P53_HUMAN
MINT-16217   CREB1_HUMAN
MINT-16582   JAK1_HUMAN
MINT-19473   FACD2_HUMAN
MINT-19477   FANCA_HUMAN
MINT-25055   BARD1_HUMAN
MINT-77954   VE7_HPV16
MINT-2490745   H4_HUMAN
MINT-2791487   RD23B_HUMAN
MINT-5115454   FANCJ_HUMAN
MINT-7213847   ABL1_HUMAN
MINT-7250578   NCK1_HUMAN
MINT-7251658   P85A_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA binding,
identical protein binding,
ubiquitin protein ligase binding,
androgen receptor binding,
RNA binding,
transcription coactivator activity,
zinc ion binding,
tubulin binding,
ubiquitin-protein ligase activity		 ribonucleoprotein complex,
gamma-tubulin ring complex,
nucleoplasm,
BRCA1-BARD1 complex,
BRCA1-A complex		 positive regulation of gene-specific transcription from RNA polymerase II promoter,
negative regulation of centriole replication,
response to estrogen stimulus,
apoptosis,
chromosome segregation,
cellular response to indole-3-methanol,
fatty acid biosynthetic process,
regulation of transcription from RNA polymerase III promoter,
cell cycle,
postreplication repair,
G2/M transition DNA damage checkpoint,
positive regulation of protein ubiquitination,
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator,
negative regulation of transcription,
positive regulation of DNA repair,
negative regulation of fatty acid biosynthetic process,
androgen receptor signaling pathway,
regulation of cell proliferation,
protein K6-linked ubiquitination,
DNA damage response, signal transduction resulting in induction of apoptosis,
double-strand break repair via homologous recombination,
response to ionizing radiation,
protein autoubiquitination
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 988 YRIPPLFPIKSFVKTKCKKNL CHK2 12111733
LTP
1.00
 - -
0.34
 --
S 988 YRIPPLFPIKSFVKTKCKKNL CHK2 14701743
LTP
1.00
 - -
0.34
 --

Substrate: Cdc25A (Protein tyrosine phosphatase activity)
Seq-ID: P79923 [Xenopus laevis]
Download:fasta csv
Interaction Network(s): -
External Source(s):
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein tyrosine phosphatase activity intracellular protein amino acid dephosphorylation,
M phase of mitotic cell cycle
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 137 GSSPAFKRNLSYSLECEVFHL CHK2 15272308
LTP
0.28
 - M-inducer_phosp
0.23
 - low
S 190 GKEGLVQRQKSAPACMLSSPR CHK2 15272308
LTP
1.00
 - M-inducer_phosp
0.58
 - low
S 295 DTPEKSKRRKSMSEIVNEGLD CHK2 15272308
LTP
1.00
 - M-inducer_phosp
0.65
 - low

Substrate: cdc25A (Dual specificity phosphatase)
Seq-ID: P30304 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-15591   CHK2_HUMAN
MINT-3294407   1433Z_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein tyrosine phosphatase activity,
protein binding		 nucleoplasm regulation of cyclin-dependent protein kinase activity,
cell division,
protein amino acid dephosphorylation,
mitosis,
DNA replication,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 124 GCSPALKRSHSDSLDHDIFQL CHK2 11298456
LTP
0.29
 - M-inducer_phosp
0.45
 - high
S 178 GKDLFTQRQNSAPARMLSSNE CHK2 12676583
LTP
1.00
 - M-inducer_phosp
0.69
 - high
S 279 TRSVLKRPERSQEESPPGSTK CHK2 12676583
LTP
0.07
 - M-inducer_phosp
0.89
 - high
S 293 SPPGSTKRRKSMSGASPKEST CHK2 12676583
LTP
1.00
 - M-inducer_phosp
0.89
 - high

Substrate: cdc25c (M-phase inducer phosphatase 3)
Seq-ID: P30307 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16690   PLK1_HUMAN
MINT-3294433   1433Z_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein tyrosine phosphatase activity,
WW domain binding		 cytosol,
nucleoplasm		 regulation of cyclin-dependent protein kinase activity,
cell division,
traversing start control point of mitotic cell cycle,
protein amino acid dephosphorylation,
regulation of mitosis,
mitosis,
interspecies interaction between organisms,
DNA replication,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 216 VSRSGLYRSPSMPENLNRPRL CHK2 10744722
LTP
0.98
 CDC25C 14-3-3;
NPHP1 14-3-3;
SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 M-inducer_phosp
0.66
 - low
S 216 VSRSGLYRSPSMPENLNRPRL CHK2 9836640
LTP
0.98
 CDC25C 14-3-3;
NPHP1 14-3-3;
SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 M-inducer_phosp
0.66
 - low

Substrate: CHK2 (Serine/threonine-protein kinase Chk2)
Seq-ID: O96017 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13742   P53_HUMAN
MINT-15591   MPIP1_HUMAN
MINT-49652   NBN_HUMAN
MINT-58599   MDM2_HUMAN
MINT-62311   IMA2_HUMAN
MINT-4793727   RB_HUMAN
MINT-6806274   STRAP_HUMAN
MINT-7294980   XRCC1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
metal ion binding,
ATP binding,
protein binding		 PML body protein amino acid phosphorylation,
senescence,
cell cycle,
DNA damage checkpoint,
DNA damage response, signal transduction resulting in induction of apoptosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 68 GTLSSLETVSTQELYSIPEDQ CHK2 11901158
LTP
0.08
 MOD_PIKK_1
 MDC1 FHA;
PLK1 PBD		 -
0.61
 --
T 383 KILGETSLMRTLCGTPTYLAP CHK2 11390408
LTP
1.00
 - S_TKc
0.13
 2W0J 40.41%
T 387 ETSLMRTLCGTPTYLAPEVLV CHK2 11390408
LTP
1.00
 - S_TKc
0.11
 2W0J 86.30%
S 516 TALPQVLAQPSTSRKRPREGE CHK2 12805407
LTP
0.08
 - -
0.69
 --

Substrate: E2F-1 (Transcription factor)
Seq-ID: Q01094 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19370   TOPB1_HUMAN
MINT-73331   VE7_HPV16
MINT-4793665   RB_HUMAN
MINT-6804982   MCPH1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription corepressor activity,
sequence-specific DNA binding transcription factor activity		 mitochondrion transcription,
G1 phase of mitotic cell cycle,
apoptosis,
mRNA stabilization,
negative regulation of transcription from RNA polymerase II promoter,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 364 EQEPLLSRMGSLRAPVDEDRL CHK2 12717439
LTP
0.11
 - -
0.59
 - medium

Substrate: p53 (Cellular tumor antigen p53)
Seq-ID: P04637 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13742   CHK2_HUMAN
MINT-15878   UBP7_HUMAN
MINT-16161   BRCA1_HUMAN
MINT-16977   PARP1_HUMAN
MINT-19990   PIN1_HUMAN
MINT-24859   ASPP2_HUMAN
MINT-45889   CEBPZ_HUMAN
MINT-49767   ATM_HUMAN
MINT-50577   SAE1_HUMAN
MINT-56524   SP1_HUMAN
MINT-58470   MED1_HUMAN
MINT-58672   HNRL1_HUMAN
MINT-60094   HIPK2_HUMAN
MINT-61312   MK08_HUMAN
MINT-61317   WWOX_HUMAN
MINT-62206   PP1A_HUMAN
MINT-63290   ARI2_HUMAN
MINT-63365   KITH_HUMAN
MINT-63497   ZNF24_HUMAN
MINT-63537   IF2B_HUMAN
MINT-63547   RAB4A_HUMAN
MINT-63559   SAT1_HUMAN
MINT-64119   STX5_HUMAN
MINT-64188   MD2BP_HUMAN
MINT-64748   K0087_HUMAN
MINT-65132   HSPB1_HUMAN
MINT-65272   MPH6_HUMAN
MINT-68565   BMX_HUMAN
MINT-74886   NPM_HUMAN
MINT-74925   1433Z_HUMAN
MINT-1795431   NMT1_HUMAN
MINT-1891378   CDN1A_HUMAN
MINT-1958329   CHK1_HUMAN
MINT-2634790   RGRF1_HUMAN
MINT-2858243   DVL2_HUMAN
MINT-2866927   SCAM1_HUMAN
MINT-3390028   KC1D_RAT
MINT-3979604   P53_MOUSE
MINT-4049689   NR4A1_HUMAN
MINT-4052116   SYVN1_HUMAN
MINT-4052873   GRP78_HUMAN
MINT-4302642   HS71L_HUMAN
MINT-4303978   XPO1_HUMAN
MINT-4329805   TOPRS_HUMAN
MINT-4793180   EGR1_HUMAN
MINT-4793253   GSK3B_HUMAN
MINT-4793489   PML_HUMAN
MINT-5114724   ZN363_HUMAN
MINT-5207405   HDAC8_HUMAN
MINT-6540866   PSME3_HUMAN
MINT-6540889   MDM2_HUMAN
MINT-6628692   LT_SV40
MINT-6665320   CBP_HUMAN
MINT-6701342   MAP1B_HUMAN
MINT-7013631   PA1_HUMAN
MINT-7013916   RYBP_HUMAN
MINT-7103733   ANDR_HUMAN
MINT-7144912   TOE1_HUMAN
MINT-7222784   FRAP_HUMAN
MINT-7263630   EP300_HUMAN
MINT-7266250   PLK1_HUMAN
MINT-7294020   FAK1_HUMAN
MINT-7295816   IKKB_HUMAN
MINT-7557644   GRP75_HUMAN
MINT-7711943   1433S_HUMAN
MINT-7717378   PHB_HUMAN
MINT-7718917   SNAI1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription activator activity,
protease binding,
DNA strand annealing activity,
chromatin binding,
copper ion binding,
ATP binding,
transcription factor binding,
chaperone binding,
zinc ion binding,
histone acetyltransferase binding,
promoter binding,
sequence-specific DNA binding transcription factor activity,
protein N-terminus binding,
protein heterodimerization activity,
protein phosphatase 2A binding,
protein kinase binding,
ubiquitin protein ligase binding		 nucleolus,
nuclear matrix,
insoluble fraction,
protein complex,
endoplasmic reticulum,
PML body,
mitochondrion		 positive regulation of gene-specific transcription from RNA polymerase II promoter,
senescence,
mitotic cell cycle G1/S DNA damage checkpoint,
cell cycle arrest,
regulation of mitochondrial membrane permeability,
response to gamma radiation,
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator,
response to tumor cell,
ER overload response,
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis,
interspecies interaction between organisms,
Ras protein signal transduction,
nucleotide-excision repair,
protein tetramerization,
cellular response to glucose starvation,
negative regulation of helicase activity,
negative regulation of cell growth,
base-excision repair,
activation of caspase activity by cytochrome c,
cell aging
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 20 VEPPLSQETFSDLWKLLPENN CHK2 17339337
LTP
0.95
 - P53_TAD
0.60
 --

Substrate: Protein kinase Cds1 (Protein serine/threonine kinase activity)
Seq-ID: Q98TW0 [Xenopus laevis]
Download:fasta csv
Interaction Network(s): -
External Source(s):
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
ATP binding		 protein amino acid phosphorylation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 355 KILGETSLMRTLCGTPTYLAP CHK2 15509799
LTP
1.00
 - S_TKc
0.15
 - medium
T 359 ETSLMRTLCGTPTYLAPEVLN CHK2 15509799
LTP
1.00
 - S_TKc
0.17
 - medium

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