List of substrates found:


Substrate: Calmodulin (Calmodulin)
Seq-ID: P62158 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-48052   IKKA_HUMAN
MINT-48084   IKKB_HUMAN
MINT-48113   IKKE_HUMAN
MINT-48186   NEMO_HUMAN
MINT-48261   TANK_HUMAN
MINT-48323   M3K1_HUMAN
MINT-48456   M3K3_HUMAN
MINT-48670   NFKB1_HUMAN
MINT-48738   NFKB2_HUMAN
MINT-48841   M3K14_HUMAN
MINT-49007   RELB_HUMAN
MINT-49067   RIPK2_HUMAN
MINT-49173   TAB1_HUMAN
MINT-49204   TAB2_HUMAN
MINT-49274   TBK1_HUMAN
MINT-49428   TNR1B_HUMAN
MINT-51638   CRFR1_HUMAN
MINT-58232   CANB1_HUMAN
MINT-58242   FKBP8_HUMAN
MINT-67316   K1683_HUMAN
MINT-3295975   1433Z_HUMAN
MINT-5114562   ZN363_HUMAN
MINT-6595938   MYO10_HUMAN
MINT-7148437   THOP1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
thioesterase binding,
N-terminal myristoylation domain binding,
calcium ion binding,
protein domain specific binding,
titin binding		 centrosome,
plasma membrane,
extracellular region,
spindle microtubule,
cytosol,
spindle pole,
nucleoplasm		 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum,
muscle contraction,
regulation of cytokinesis,
response to calcium ion,
negative regulation of ryanodine-sensitive calcium-release channel activity,
positive regulation of ryanodine-sensitive calcium-release channel activity,
G-protein coupled receptor protein signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 100 FRVFDKDGNGYISAAELRHVM EGFR 7925415
LTP
0.46
 - EFh
0.31
 1FW4 36.68%

Substrate: CD227 (CD antigen)
Seq-ID: P15941 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
MINT-2880967   ABL1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
extracellular region,
cytoplasm,
integral to plasma membrane,
nucleus,
apical plasma membrane
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1229 VPPSSTDRSPYEKVSAGNGGS EGFR 11483589
LTP
0.00
 - -
0.54
 - low

Substrate: EGFR (Receptor for EGF and other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor,)
Seq-ID: P00533 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16802   GRB10_HUMAN
MINT-50935   1433Z_HUMAN
MINT-51101   ANXA1_HUMAN
MINT-51490   ARBK1_HUMAN
MINT-60973   CBL_HUMAN
MINT-61486   CRKL_HUMAN
MINT-61487   CSK_HUMAN
MINT-61490   STA5B_HUMAN
MINT-61540   GRB2_HUMAN
MINT-68514   PDC6I_HUMAN
MINT-74427   ABL1_HUMAN
MINT-74438   ABL2_HUMAN
MINT-74460   ANS1A_HUMAN
MINT-74469   APBB1_HUMAN
MINT-74479   DP13A_HUMAN
MINT-74487   BMX_HUMAN
MINT-74497   CRK_HUMAN
MINT-74535   FES_HUMAN
MINT-74551   IRS1_HUMAN
MINT-74555   IRS4_HUMAN
MINT-74562   JAK2_HUMAN
MINT-74566   SH2B3_HUMAN
MINT-74572   JIP1_HUMAN
MINT-74587   NCK1_HUMAN
MINT-74593   NUMB_HUMAN
MINT-74594   NUMBL_HUMAN
MINT-74606   P85A_HUMAN
MINT-74630   P85B_HUMAN
MINT-74659   P55G_HUMAN
MINT-74678   PLCG1_HUMAN
MINT-74685   PLCG2_HUMAN
MINT-74687   PTK6_HUMAN
MINT-74689   PTN11_HUMAN
MINT-74711   RASA1_HUMAN
MINT-74717   SH2B1_HUMAN
MINT-74720   SH22A_HUMAN
MINT-74732   SHC1_HUMAN
MINT-74746   SLAP1_HUMAN
MINT-74763   KSYK_HUMAN
MINT-74790   TLN1_HUMAN
MINT-74807   ZAP70_HUMAN
MINT-1788719   ERBB2_HUMAN
MINT-6169667   ESR1_HUMAN
MINT-6170031   SOS1_MOUSE
MINT-6170198   SH3G2_HUMAN
MINT-6170268   SH3K1_HUMAN
MINT-6793358   PTN1_HUMAN
MINT-7980526   TM1L1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
epidermal growth factor receptor activity,
protein heterodimerization activity,
identical protein binding,
receptor signaling protein tyrosine kinase activity,
double-stranded DNA binding,
ATP binding,
protein phosphatase binding,
actin filament binding,
MAP/ERK kinase kinase activity		 Shc-EGFR complex,
endosome,
basolateral plasma membrane,
integral to membrane,
extracellular space,
nucleus		 activation of phospholipase C activity,
protein insertion into membrane,
response to UV-A,
positive regulation of nitric oxide biosynthetic process,
positive regulation of cell migration,
positive regulation of cyclin-dependent protein kinase activity involved in G1/S,
positive regulation of catenin protein nuclear translocation,
regulation of nitric-oxide synthase activity,
positive regulation of protein kinase B signaling cascade,
ossification,
positive regulation of epithelial cell proliferation,
activation of phospholipase A2 activity by calcium-mediated signaling,
cell-cell adhesion,
regulation of peptidyl-tyrosine phosphorylation,
positive regulation of phosphorylation,
positive regulation of MAP kinase activity,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1092 IDDTFLPVPEYINQSVPKRPA EGFR 8845374
LTP
0.05
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2		 -
0.57
 --
Y 1110 RPAGSVQNPVYHNQPLNPAPS EGFR 8845374
LTP
1.00
 GRB2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 PTB;
Src SH2;
STAT3 SH2		 -
0.80
 --
Y 1172 SHQISLDNPDYQQDFFPKEAK EGFR 8845374
LTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 PTB;
SHC3 PTB;
Src SH2;
VAV2 SH2		 -
0.67
 --
Y 1197 FKGSTAENAEYLRVAPQSSEF EGFR 8845374
LTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2		 -
0.54
 --

Substrate: EGFR (Receptor for EGF and other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor,)
Seq-ID: Q01279 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-49967   EPS15_MOUSE
MINT-60748   DOK2_MOUSE
MINT-6765439   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
epidermal growth factor receptor activity,
receptor signaling protein tyrosine kinase activity,
ATP binding		 basolateral plasma membrane,
integral to membrane,
endocytic vesicle		 cerebral cortex cell migration,
hair follicle development,
embryonic placenta development,
protein amino acid autophosphorylation,
positive regulation of epithelial cell proliferation,
digestive tract morphogenesis,
regulation of peptidyl-tyrosine phosphorylation,
salivary gland morphogenesis,
morphogenesis of an epithelial fold
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1069 RVKEDAFLQRYSSDPTGAVTE EGFR 10635327
LTP
1.00
 - -
0.54
 --

Substrate: Erzin (Connection of cytoscheletro structure to plasma membrane)
Seq-ID: P15311 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-73250   TB10A_HUMAN
MINT-73254   PLCB3_HUMAN
MINT-73256   NHRF1_HUMAN
MINT-3318887   1433Z_HUMAN
MINT-6380786   FES_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cell adhesion molecule binding,
actin filament binding		 filopodium,
cortical cytoskeleton,
actin filament,
cytosol,
ruffle membrane,
microvillus membrane,
extrinsic to membrane,
apical plasma membrane		 membrane to membrane docking,
regulation of cell shape,
actin filament bundle assembly,
cytoskeletal anchoring at plasma membrane,
leukocyte cell-cell adhesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 146 DYNKEVHKSGYLSSERLIPQR EGFR 1382070
LTP
0.76
 - B41
0.26
 1NI2 9.61%
Y 354 KEELMLRLQDYEEKTKKAERE EGFR 1382070
LTP
0.22
 PIK3R1 SH2 COIL
0.49
 --

Substrate: Gab1 (Multisubstrate docking protein downstream in the signaling pathways of different RTK.)
Seq-ID: Q13480 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-58395   GRB2_HUMAN
MINT-58403   GRAP2_HUMAN
MINT-58404   MET_HUMAN
MINT-68564   BMX_HUMAN
MINT-1893011   P85A_HUMAN
MINT-6169406   PTN11_HUMAN
MINT-6169502   PAXI_HUMAN
MINT-7971128   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3/SH2 adaptor activity cytosol epidermal growth factor receptor signaling pathway,
insulin receptor signaling pathway,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 285 PSSTEADGELYVFNTPSGTSS EGFR 9890893
LTP
0.93
 - -
0.71
 - low
Y 307 ETQMRHVSISYDIPPTPGNTY EGFR 10734310
LTP
0.12
 CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2		 -
0.70
 - low
Y 373 PRTASDTDSSYCIPTAGMSPS EGFR 9890893
LTP
0.08
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.66
 - low
Y 406 LRKDASSQDCYDIPRAFPSDR EGFR 9890893
LTP
1.00
 CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2;
SHC_group SH2		 -
0.61
 - low
Y 447 SVSSEELDENYVPMNPNSPPR EGFR 9890893
LTP
1.00
 PIK3R1 SH2;
PIK3R2 SH2;
PTPN11 SH2		 -
0.83
 - low
Y 472 SFTEPIQEANYVPMTPGTFDF EGFR 9890893
LTP
1.00
 PIK3R1 SH2;
PIK3R2 SH2		 -
0.54
 - low
Y 589 SSDSHDSEENYVPMNPNLSSE EGFR 9890893
LTP
1.00
 PIK3R1 SH2;
PTPN11 SH2		 -
0.89
 - low
Y 627 IKPKGDKQVEYLDLDLDSGKS EGFR 9890893
LTP
1.00
 PTPN11 SH2 -
0.72
 - low
Y 659 GSSVADERVDYVVVDQQKTLA EGFR 9890893
LTP
1.00
 PTPN11 SH2 -
0.61
 - low

Substrate: Gab1 (Multisubstrate docking protein downstream in the signaling pathways of different RTK.)
Seq-ID: Q9QYY0 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-58371   MET_MOUSE
MINT-58374   MET_HUMAN
MINT-58378   PLCG1_MOUSE
MINT-58379   SHC1_MOUSE
MINT-58385   SHIP2_HUMAN
MINT-58390   CRKL_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
signal transducer activity,
protein binding		 cytoplasm epidermis development,
interleukin-6-mediated signaling pathway,
positive regulation of MAPKKK cascade,
regulation of cell migration,
response to oxidative stress,
activation of JUN kinase activity,
epidermal growth factor receptor signaling pathway,
heart development,
labyrinthine layer development,
platelet-derived growth factor receptor signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 285 PSSTEADGELYTFNTPSGTAG EGFR 10734310
LTP
0.93
 - -
0.77
 - medium
Y 307 ETQMRHVSISYDIPPTPGNTY EGFR 10734310
LTP
0.12
 - -
0.71
 - medium
Y 373 PRTASDTDSSYCIPPPAGMTP EGFR 10734310
LTP
0.08
 - -
0.75
 - medium
Y 407 LRKDASSQDCYDIPRTFPSDR EGFR 10734310
LTP
1.00
 - -
0.66
 - medium
Y 448 GVSGEELDENYVPMNPNSPPR EGFR 10734310
LTP
1.00
 - -
0.87
 - medium
Y 473 SFTEPIQEPNYVPMTPGTFDF EGFR 10734310
LTP
1.00
 - -
0.61
 - medium
Y 590 SSDSHDSEENYVPMNPNLSGE EGFR 10734310
LTP
1.00
 - -
0.90
 - medium
Y 628 NKPKGDKQVEYLDLDLDSGKS EGFR 10734310
LTP
1.00
 - -
0.78
 - medium
Y 660 GSSMADERVDYVVVDQQKTLA EGFR 10734310
LTP
1.00
 - -
0.68
 - medium

Substrate: Grb2 (Adaptor molecule)
Seq-ID: P62993 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14744   RPGF1_HUMAN
MINT-49659   A4_HUMAN
MINT-50656   MAP2_HUMAN
MINT-58395   GAB1_HUMAN
MINT-60975   RET_HUMAN
MINT-61518   ERBB3_HUMAN
MINT-61534   ERBB4_HUMAN
MINT-61537   SHC1_HUMAN
MINT-61540   EGFR_HUMAN
MINT-61541   IQGA1_HUMAN
MINT-61542   RGAP1_HUMAN
MINT-61546   AP2B1_HUMAN
MINT-61548   AP2M1_HUMAN
MINT-61549   CBLB_HUMAN
MINT-61552   PTN11_HUMAN
MINT-61554   K2C7_HUMAN
MINT-61555   K2C8_HUMAN
MINT-61556   K1C17_HUMAN
MINT-61557   K1C18_HUMAN
MINT-61558   PLEC1_HUMAN
MINT-61559   EPIPL_HUMAN
MINT-61561   H31_HUMAN
MINT-61562   SMD2_HUMAN
MINT-62810   BAT2_HUMAN
MINT-62876   ACK1_HUMAN
MINT-65952   DYN1_HUMAN
MINT-65974   P85A_HUMAN
MINT-74542   ERBB2_HUMAN
MINT-2516705   DYN2_HUMAN
MINT-2792931   PAK2_HUMAN
MINT-3381238   VGFR2_HUMAN
MINT-3382436   LAT_HUMAN
MINT-6169717   SPY1_HUMAN
MINT-6169734   SPY2_HUMAN
MINT-6169976   SOS1_MOUSE
MINT-6170118   SOS1_HUMAN
MINT-6762786   IRS1_RAT
MINT-6794792   PTN1_HUMAN
MINT-7040249   CBL_HUMAN
MINT-7144603   BLNK_HUMAN
MINT-7212968   M4K1_HUMAN
MINT-7218139   ADA15_HUMAN
MINT-7219650   CDN1B_HUMAN
MINT-7220613   GAB2_HUMAN
MINT-7253206   FANCA_HUMAN
MINT-7253218   ABL1_HUMAN
MINT-7253230   FLNB_HUMAN
MINT-7253290   FLNA_HUMAN
MINT-7253314   FLNC_HUMAN
MINT-7253338   RRAS_HUMAN
MINT-7253374   SHAN2_HUMAN
MINT-7253410   PHAR2_HUMAN
MINT-7253470   DLGP4_HUMAN
MINT-7253494   TGON2_HUMAN
MINT-7253518   ICAL_HUMAN
MINT-7253542   KI13A_HUMAN
MINT-7253590   SHRM2_HUMAN
MINT-7253662   SUV92_HUMAN
MINT-7253674   ARHGB_HUMAN
MINT-7253686   AKAP2_HUMAN
MINT-7253698   SNX3_HUMAN
MINT-7253734   ASAP1_HUMAN
MINT-7253770   PTN13_HUMAN
MINT-7253782   ABL2_HUMAN
MINT-7253806   BAZ2A_HUMAN
MINT-7253818   TRAIP_HUMAN
MINT-7253842   TAL2_HUMAN
MINT-7306657   LCP2_HUMAN
MINT-7980585   TM1L1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
epidermal growth factor receptor binding,
insulin receptor substrate binding,
SH3/SH2 adaptor activity		 cytosol,
Golgi apparatus		 epidermal growth factor receptor signaling pathway,
cell-cell signaling,
interspecies interaction between organisms,
Ras protein signal transduction,
insulin receptor signaling pathway,
receptor internalization
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 209 HGQTGMFPRNYVTPVNRNV   EGFR 11726515
LTP
1.00
 - SH3
0.39
 2VWF 35.37%

Substrate: Hrs (Adapter molecule)
Seq-ID: O14964 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-50313   TS101_HUMAN
MINT-58565   TM1L1_HUMAN
MINT-58566   TOM1_HUMAN
MINT-58567   GGA1_HUMAN
MINT-66293   K1C19_HUMAN
MINT-66600   EHMT2_HUMAN
MINT-66780   EXOC8_HUMAN
MINT-67563   BEGIN_HUMAN
MINT-67925   STAM2_HUMAN
MINT-68023   K1C18_HUMAN
MINT-68442   STAM1_HUMAN
MINT-2866086   UBQL4_HUMAN
MINT-6173438   CEP55_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein domain specific binding,
zinc ion binding		 multivesicular body membrane,
early endosome membrane,
cytosol		 negative regulation of cell proliferation,
endosome transport,
signal transduction,
intracellular protein transport,
negative regulation of JAK-STAT cascade,
regulation of protein catabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 329 AEDIDPELARYLNRNYWEKKQ EGFR 12953068
LTP
1.00
 - -
0.59
 - medium

Substrate: Lipocortin I (annexinI) ( Ca++, phospholipids and actin-binding protein)
Seq-ID: P04083 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-51101   EGFR_HUMAN
MINT-3297886   1433Z_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
calcium-dependent phospholipid binding,
calcium ion binding,
phospholipase A2 inhibitor activity,
protein binding, bridging,
structural molecule activity,
receptor binding		 extracellular region,
cilium,
cytoplasm,
basolateral plasma membrane,
cornified envelope,
nucleus		 positive regulation of vesicle fusion,
lipid metabolic process,
keratinocyte differentiation,
anti-apoptosis,
cellular component movement,
signal transduction,
inflammatory response,
cell surface receptor linked signaling pathway,
peptide cross-linking
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 21 AWFIENEEQEYVQTVKSSKGG EGFR 2457390
LTP
0.13
 - -
0.42
 --

Substrate: Lipocortin I (annexinI) ( Ca++, phospholipids and actin-binding protein)
Seq-ID: P19619 [Sus scrofa]
Download:fasta csv
Interaction Network(s): -
External Source(s):
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
calcium-dependent phospholipid binding,
calcium ion binding,
phospholipase A2 inhibitor activity		 cilium,
cytoplasm,
basolateral plasma membrane,
nucleus
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 21 AWFIDNEEQEYIKTVKGSKGG EGFR 3020049
LTP
0.15
 - -
0.42
 1HM6 6.55%

Substrate: Myosin regulatory light chain 2, smooth muscle (myosin regulatory light chain 2, smooth muscle major isoform (from PhosphoBase))
Seq-ID: P02612 [Gallus gallus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s):
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
calcium ion binding,
motor activity		 myosin complex
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 143 RFTDEEVDEMYREAPIDKKGN EGFR 6313687
LTP
0.31
 - -
0.49
 - low
Y 156 APIDKKGNFNYVEFTRILKHG EGFR 6313687
LTP
0.93
 - -
0.26
 - low

Substrate: Myosin regulatory light chain 2, smooth muscle isoform
Seq-ID: P24844 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
calcium ion binding,
structural constituent of muscle,
motor activity		 muscle myosin complex muscle contraction,
regulation of muscle contraction
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 143 RFTDEEVDEMYREAPIDKKGN EGFR 8578591
LTP
0.31
 - -
0.49
 - low
Y 156 APIDKKGNFNYVEFTRILKHG EGFR 8578591
LTP
0.93
 - -
0.26
 - low

Substrate: PKI-alpha (cAMP-dependent protein kinase inhibitor, muscle/brain form (from PhosphoBase))
Seq-ID: P61925 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
Molecular FunctionCellular ComponentBiological Process
cAMP-dependent protein kinase inhibitor activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 8    MTDVETTYADFIASGRTG EGFR 1956339
LTP
0.76
 - PKI
0.55
 - low

Substrate: PLC gamma 1 (Major substrate for eparin binding growth factor)
Seq-ID: P08487 [Bos taurus]
Download:fasta csv
Interaction Network(s): -
External Source(s):
MINT Interaction(s):
[show]
MINT-2837344   CBL_HUMAN
MINT-2837376   VAV_HUMAN
MINT-2837400   LCP2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoinositide phospholipase C activity,
signal transducer activity		 in utero embryonic development,
phospholipid catabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 472 KHKKLAEGSAYEEVPTSVMYS EGFR 1708307
LTP
0.14
 - -
0.38
 - medium
Y 771 LEKIGTAEPDYGALYEGRNPG EGFR 1708307
LTP
0.12
 - -
0.38
 - medium
Y 783 ALYEGRNPGFYVEANPMPTFK EGFR 1708307
LTP
1.00
 - -
0.29
 - medium
Y 1254 RAREGSFEARYQQPFEDFRIS EGFR 1689310
LTP
0.14
 - -
0.39
 - medium
Y 1254 RAREGSFEARYQQPFEDFRIS EGFR 1708307
LTP
0.14
 - -
0.39
 - medium

Substrate: PLC gamma 1 (Major substrate for eparin binding growth factor)
Seq-ID: P19174 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19688   RBP2_MOUSE
MINT-74678   EGFR_HUMAN
MINT-74680   ERBB2_HUMAN
MINT-74682   ERBB3_HUMAN
MINT-7146767   AKT1_HUMAN
MINT-7229970   RAC1_HUMAN
MINT-7231507   PLD1_HUMAN
MINT-7252402   ICAL_HUMAN
MINT-7252438   TRAIP_HUMAN
MINT-7252450   SNX17_HUMAN
MINT-7252486   ASAP2_HUMAN
MINT-7252498   ARHGB_HUMAN
MINT-7252534   ASAP1_HUMAN
MINT-7252546   RRAS_HUMAN
MINT-7252558   M4K1_HUMAN
MINT-7252594   GHR_HUMAN
MINT-7252618   RGS7_HUMAN
MINT-7252642   CKAP5_HUMAN
MINT-7252666   JAK2_HUMAN
MINT-7252678   SOS1_HUMAN
MINT-7252690   FLNB_HUMAN
MINT-7252714   FLNA_HUMAN
MINT-7252738   ABL1_HUMAN
MINT-7252750   SUV92_HUMAN
MINT-7252762   SC24B_HUMAN
MINT-7252786   FCG2B_HUMAN
MINT-7252798   FCG2C_HUMAN
MINT-7252810   PHAR2_HUMAN
MINT-7252846   FANCA_HUMAN
MINT-7252858   TGON2_HUMAN
MINT-7252882   CAF1A_HUMAN
MINT-7252894   MAP4_HUMAN
MINT-7252954   SHAN2_HUMAN
MINT-7252966   DNLI3_HUMAN
MINT-7252978   NELFB_HUMAN
MINT-7253038   DTBP1_HUMAN
MINT-7253050   ABL2_HUMAN
MINT-7253062   AKAP2_HUMAN
MINT-7253086   FLNC_HUMAN
MINT-7253122   MINT_HUMAN
MINT-7253146   LIPA4_HUMAN
MINT-7253158   ADNP_HUMAN
MINT-7306637   LCP2_HUMAN
MINT-7309951   SCRB2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoinositide phospholipase C activity,
receptor signaling protein activity		 plasma membrane,
cytosol		 interspecies interaction between organisms,
phospholipid catabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 771 LEKIGTAEPDYGALYEGRNPG EGFR 1689310
LTP
0.12
 - -
0.36
 - medium
Y 783 ALYEGRNPGFYVEANPMPTFK EGFR 1689310
LTP
1.00
 - -
0.28
 - medium
Y 1253 RAREGSFESRYQQPFEDFRIS EGFR 1689310
LTP
0.13
 - -
0.41
 - medium

Substrate: Protein 4.1 (Erythrocyte protein 4.1)
Seq-ID: P11171 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-51239   SMAD3_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
spectrin binding,
structural constituent of cytoskeleton,
phosphatidylinositol binding,
actin binding		 plasma membrane,
spectrin-associated cytoskeleton,
nucleus,
extrinsic to membrane,
protein complex,
spectrin		 cortical actin cytoskeleton organization,
positive regulation of protein binding,
blood circulation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 660 KRERLDGENIYIRHSNLMLED EGFR 1647028
LTP
1.00
 - -
0.53
 - medium

Substrate: Protein Eps15 (Epidermal growth factor receptor substrate 15)
Seq-ID: P42567 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-49967   EGFR_MOUSE
MINT-50455   AP2A2_MOUSE
MINT-5206832   ITSN1_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
calcium ion binding		 plasma membrane,
early endosome membrane		 protein transport
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 850 DPSNFANFSAYPSEEDMIEWA EGFR 10953014
LTP
0.41
 - -
0.61
 --

Substrate: Ras GTPase-activating protein 1 (Ras p21 activator protein (GAP))
Seq-ID: P20936 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-74708   ERBB3_HUMAN
MINT-74709   ERBB4_HUMAN
MINT-74711   EGFR_HUMAN
MINT-74712   ERBB2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
potassium channel inhibitor activity,
Ras GTPase activator activity,
glycoprotein binding,
GTPase binding,
receptor binding		 cytoplasm intracellular signaling pathway,
cytokinesis,
regulation of actin filament polymerization,
positive regulation of anti-apoptosis,
regulation of cell shape,
signal transduction,
negative regulation of cell-matrix adhesion,
vasculogenesis,
negative regulation of neuron apoptosis,
regulation of small GTPase mediated signal transduction,
regulation of RNA metabolic process,
embryo development
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 460 LNDTVDGKEIYNTIRRKTKDA EGFR 1850098
LTP
1.00
 Lck SH2;
Src SH2		 -
0.31
 - low

Substrate: RGS16 (Regulator of G-protein signaling 16)
Seq-ID: O15492 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
GTPase activator activity,
calmodulin binding,
signal transducer activity		 negative regulation of signal transduction,
visual perception,
regulation of G-protein coupled receptor protein signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 168 KTRTLMEKDSYPRFLKSPAYR EGFR 11602604
LTP
1.00
 - RGS
0.34
 2BT2 9.17%
Y 177 SYPRFLKSPAYRDLAAQASAA EGFR 11602604
LTP
1.00
 Src SH2 RGS
0.29
 2BT2 0.87%

Substrate: STAT 5B (Transcription factor)
Seq-ID: P51692 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-58270   STAP2_HUMAN
MINT-61490   EGFR_HUMAN
MINT-61524   ERBB4_HUMAN
MINT-6794005   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
glucocorticoid receptor binding,
calcium ion binding,
sequence-specific DNA binding transcription factor activity		 nucleus valine metabolic process,
oxaloacetate metabolic process,
creatinine metabolic process,
isoleucine metabolic process,
taurine metabolic process,
response to estradiol stimulus,
allantoin metabolic process,
fatty acid metabolic process,
citrate metabolic process,
JAK-STAT cascade involved in growth hormone signaling pathway,
2-oxoglutarate metabolic process,
succinate metabolic process,
creatine metabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 725 SADAGGGSATYMDQAPSPAVC EGFR 11751923
LTP
0.03
 - -
0.54
 - medium
Y 740 PSPAVCPQAHYNMYPQNPDSV EGFR 11751923
LTP
0.03
 - -
0.53
 - medium
Y 743 AVCPQAHYNMYPQNPDSVLDT EGFR 11751923
LTP
0.15
 - -
0.51
 - medium

Substrate: Tyrosine-protein phosphatase, non-receptor type 1 (Protein tyrosine phosphatase 1B)
Seq-ID: P18031 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-51115   PPIP1_HUMAN
MINT-73489   CADH2_HUMAN
MINT-6744190   CSK21_HUMAN
MINT-6761890   GSK3B_HUMAN
MINT-6761899   ESR1_HUMAN
MINT-6762163   IKBA_HUMAN
MINT-6762380   PGFRB_HUMAN
MINT-6762549   PAXI_MOUSE
MINT-6762573   FAK1_MOUSE
MINT-6762866   IRS1_RAT
MINT-6763504   BCAR1_MOUSE
MINT-6763556   INSR_RAT
MINT-6764602   JAK2_HUMAN
MINT-6764613   STAT3_HUMAN
MINT-6764665   TRPV6_HUMAN
MINT-6764866   CAV1_HUMAN
MINT-6765163   PIAS1_HUMAN
MINT-6765185   SUMO1_HUMAN
MINT-6765318   CTND1_MOUSE
MINT-6765333   LPP_MOUSE
MINT-6765355   SRC8_MOUSE
MINT-6765370   ZO1_MOUSE
MINT-6765383   PLCG1_MOUSE
MINT-6765422   DOK1_MOUSE
MINT-6765439   EGFR_MOUSE
MINT-6765460   PGFRB_MOUSE
MINT-6787689   MET_HUMAN
MINT-6787710   ABL1_HUMAN
MINT-6793324   B3AT_HUMAN
MINT-6793358   EGFR_HUMAN
MINT-6793387   CAN1_HUMAN
MINT-6793394   CAN2_HUMAN
MINT-6793439   IRS1_MOUSE
MINT-6793452   INSR_MOUSE
MINT-6793484   BCAR1_HUMAN
MINT-6793722   AKT1_MOUSE
MINT-6793745   IRS1_HUMAN
MINT-6793782   TYK2_HUMAN
MINT-6793941   NTRK1_HUMAN
MINT-6793957   NTRK3_HUMAN
MINT-6793973   LTK_HUMAN
MINT-6793989   STA5A_HUMAN
MINT-6794005   STA5B_HUMAN
MINT-6794135   LAT_HUMAN
MINT-6794748   EPOR_HUMAN
MINT-6794792   GRB2_HUMAN
MINT-6794817   ITB3_HUMAN
MINT-6794878   ACTS_HUMAN
MINT-6794892   FAK1_HUMAN
MINT-6794946   INSR_HUMAN
MINT-6794972   KPCG_HUMAN
MINT-6795050   JAK2_MOUSE
MINT-6795199   SRC8_HUMAN
MINT-6795447   SRC_HUMAN
MINT-6796717   PLD2_HUMAN
MINT-6797067   CLK2_HUMAN
MINT-6797829   GHR_HUMAN
MINT-6799814   ROS_HUMAN
MINT-6800783   IGF1R_HUMAN
MINT-7972220   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein tyrosine phosphatase activity,
zinc ion binding		 cytosol,
endoplasmic reticulum membrane		 negative regulation of insulin receptor signaling pathway,
signal transduction
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 66 RIKLHQEDNDYINASLIKMEE EGFR 9355745
LTP
1.00
 - PTPc
0.36
 2CM2 0.00%

Substrate: Vav 2 (Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases)
Seq-ID: P52735 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-74802   ERBB2_HUMAN
MINT-74803   ERBB3_HUMAN
MINT-7301276   3BP2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
Rho guanyl-nucleotide exchange factor activity,
metal ion binding		 cytosol induction of apoptosis by extracellular signals,
angiogenesis,
apoptosis,
regulation of Rho protein signal transduction
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 142 EETTENDDDVYRSLEELADEH EGFR 12454019
LTP
1.00
 - -
0.54
 - low
Y 159 ADEHDLGEDIYDCVPCEDGGD EGFR 12454019
LTP
0.04
 - -
0.31
 - low
Y 172 VPCEDGGDDIYEDIIKVEVQQ EGFR 12454019
LTP
1.00
 - -
0.25
 - low

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