List of substrates found:


Substrate: FGFR-1 (Receptor tyrosine kinase)
Seq-ID: P11362 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
MINT-74539   ERBB3_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
heparin binding,
fibroblast growth factor receptor activity,
ATP binding		 extracellular region,
membrane fraction,
integral to plasma membrane		 protein amino acid phosphorylation,
MAPKKK cascade,
cell growth
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 154 TKPNRMPVAPYWTSPEKMEKK FGFR1 12601080
LTP
0.25
 - -
0.62
 1CVS 50.66%
Y 280 GSNVEFMCKVYSDPQPHIQWL FGFR1 12601080
LTP
0.83
 - IGc2
0.16
 1CVS 51.09%
Y 307 GSKIGPDNLPYVQILKTAGVN FGFR1 12601080
LTP
0.88
 - IGc2
0.26
 1CVS 29.26%
Y 463 GTPMLAGVSEYELPEDPRWEL FGFR1 8622701
LTP
0.65
 - -
0.41
 --
Y 583 LQARRPPGLEYCYNPSHNPEE FGFR1 8622701
LTP
1.00
 - TyrKc
0.48
 --
Y 585 ARRPPGLEYCYNPSHNPEEQL FGFR1 8622701
LTP
0.61
 - TyrKc
0.51
 --
Y 605 LSSKDLVSCAYQVARGMEYLA FGFR1 12601080
LTP
0.97
 - TyrKc
0.12
 1FGK 15.72%
Y 653 GLARDIHHIDYYKKTTNGRLP FGFR1 8622701
LTP
1.00
 - TyrKc
0.20
 1FGK 19.21%
Y 654 LARDIHHIDYYKKTTNGRLPV FGFR1 8622701
LTP
1.00
 - TyrKc
0.20
 1FGK 67.69%
Y 730 DKPSNCTNELYMMMRDCWHAV FGFR1 8622701
LTP
1.00
 - TyrKc
0.26
 1FGK 15.28%
Y 766 RIVALTSNQEYLDLSMPLDQY FGFR1 8622701
LTP
0.89
 PLCG1 SH2 -
0.29
 --

Substrate: Heterogeneous nuclear ribonucleoprotein Q (RNA binding)
Seq-ID: O60506 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-7041249   HABP4_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
nucleotide binding,
protein binding		 microsome,
spliceosomal complex,
nucleoplasm,
CRD-mediated mRNA stability complex,
histone pre-mRNA 3`end processing complex,
endoplasmic reticulum		 mRNA processing,
interspecies interaction between organisms,
RNA splicing,
CRD-mediated mRNA stabilization
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 373 KLERVKKLKDYAFIHFDERDG FGFR1 12601080
LTP
1.00
 - RRM
0.22
 --

Substrate: P130Cas (Adaptor molecule. Contain 15 YxxP motifs. )
Seq-ID: P56945 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-74936   PTN12_HUMAN
MINT-74938   FAK1_HUMAN
MINT-3974941   1433S_HUMAN
MINT-6174734   ACTB_HUMAN
MINT-6763936   CRK_HUMAN
MINT-6793484   PTN1_HUMAN
MINT-7104353   CDC42_HUMAN
MINT-7104422   SRC_HUMAN
MINT-7104436   ACK1_HUMAN
MINT-7247002   FYN_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
protein kinase binding,
protein phosphatase binding,
signal transducer activity		 focal adhesion,
membrane fraction,
cytosol,
ruffle		 regulation of cell growth,
B cell receptor signaling pathway,
cell division,
positive regulation of cell migration,
nerve growth factor receptor signaling pathway,
cell migration,
integrin-mediated signaling pathway,
epidermal growth factor receptor signaling pathway,
actin filament organization,
regulation of apoptosis,
platelet-derived growth factor receptor signaling pathway,
T cell receptor signaling pathway,
cell adhesion,
insulin receptor signaling pathway,
cell proliferation,
G-protein coupled receptor protein signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 128 PTPSKAQQGLYQVPGPSPQFQ FGFR1 12601080
LTP
 - CRKL SH2;
CRK SH2		 -
0.76
 - medium
Y 249 HLLAPGPQDIYDVPPVRGLLP FGFR1 12601080
LTP
1.00
 ABL1 SH2;
CRKL SH2;
CRK SH2		 -
0.56
 - medium
Y 306 GLPPSNHHAVYDVPPSVSKDV FGFR1 12601080
LTP
0.94
 ABL1 SH2;
CRKL SH2;
CRK SH2		 -
0.73
 - medium
Y 327 PDGPLLREETYDVPPAFAKAK FGFR1 12601080
LTP
1.00
 CRKL SH2;
CRK SH2		 -
0.61
 - medium
Y 410 ADGGVVDSGVYAVPPPAEREA FGFR1 12601080
LTP
1.00
 ABL1 SH2;
CRKL SH2;
CRK SH2		 -
0.72
 - medium

Substrate: S6K-alpha 3 (Serine/threonine kinase)
Seq-ID: P51812 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
magnesium ion binding,
protein serine/threonine kinase activity,
ATP binding		 cytosol,
nucleoplasm		 protein amino acid phosphorylation,
central nervous system development,
skeletal system development,
intracellular protein kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 707 HLVKGAMAATYSALNRNQSPV FGFR1 12601080
LTP
0.97
 - -
0.38
 2QR8 5.68%

Substrate: Src substrate cortactin (Involved in the organization of cell structure)
Seq-ID: Q14247 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-6541916   WASL_HUMAN
MINT-6541935   PAK1_HUMAN
MINT-6541954   PAK2_HUMAN
MINT-6795199   PTN1_HUMAN
MINT-7103135   KCMA1_MOUSE
MINT-7145534   ASAP1_HUMAN
MINT-7145612   DYN2_HUMAN
MINT-7306884   MTSS1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein binding lamellipodium,
cytoskeleton,
soluble fraction,
cell cortex,
ruffle
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 446 PVSGTEPEPVYSMEAADYREA FGFR1 12601080
LTP
0.93
 - -
0.71
 --

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