Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

ATP-citrate synthase
Aurora kinase A
Beta-catenin
c-Jun
c-Myb
c-myc
C/EBP alpha
Calcipressin 1
cAMP-dependent protein kinase type II-alpha regulatory subunit
CREB
Cyclin D1
E-cadherin
eIF-2B
glycogen synthase
HSF 1
IPP2
Mdm2
MLCK
p53

Substrate:

ATP-citrate synthase (ATPase)

Seq-ID:

P53396 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
ATP citrate synthase activity, metal ion binding, ATP binding, succinate-CoA ligase (ADP-forming) activity, citrate (pro-3S)-lyase activity, protein binding	cytosol, citrate lyase complex	coenzyme A metabolic process, ATP catabolic process, citrate metabolic process, cellular carbohydrate metabolic process, lipid biosynthetic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	447	FLLNASGSTSTPAPSRTASFS	GSK-3_group	2176822	LTP	0.64	MOD_GSK3_1	-	-	0.59	-	medium
S	451	ASGSTSTPAPSRTASFSESRA	GSK-3_group	2176822	LTP	0.55	MOD_GSK3_1	-	-	0.73	-	medium

Substrate:

Aurora kinase A (Serine/threonine kinase)

Seq-ID:

Q91820 [Xenopus laevis]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, ATP binding, microtubule binding, kinesin binding	centrosome, spindle microtubule, spindle pole	cell division, peptidyl-serine phosphorylation, protein amino acid autophosphorylation, mitosis, spindle assembly involved in mitosis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	290	ADFGWSVHAPSSRRTTLCGTL	GSK-3_group	14724178	LTP	0.79	MOD_GSK3_1	-	S_TKc	0.17	-	medium
S	291	DFGWSVHAPSSRRTTLCGTLD	GSK-3_group	14724178	LTP	0.75	MOD_GSK3_1	-	S_TKc	0.18	-	medium
S	349	DTHQETYRRISKVEFQYPPYV	GSK-3_group	14724178	LTP	0.56		-	S_TKc	0.36	-	medium

Substrate:

Beta-catenin (Adhesion molecule)

Seq-ID:

P35222 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-46005   CADH1_HUMAN
MINT-46006   CTNA1_HUMAN
MINT-49803   ANDR_HUMAN
MINT-49805   NCOA2_HUMAN
MINT-1779698   TF7L2_HUMAN
MINT-1792780   LAP2_HUMAN
MINT-1792796   PKP4_HUMAN
MINT-2839028   LAP2B_HUMAN
MINT-2839079   EMD_HUMAN
MINT-4085223   CADH5_HUMAN
MINT-4085261   PARD3_HUMAN
MINT-4085491   CADH2_HUMAN
MINT-4508051   GSK3B_HUMAN
MINT-4508065   ITF2_HUMAN
MINT-4508192   AXN1_HUMAN
MINT-4508216   ABL1_HUMAN
MINT-4508229   APC_HUMAN
MINT-6823807   HDAC1_HUMAN
MINT-7023862   NFKB1_HUMAN
MINT-7952417   TNIK_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
R-SMAD binding, cadherin binding, androgen receptor binding, alpha-catenin binding, kinase binding, protein phosphatase binding, transcription coactivator activity, promoter binding, signal transducer activity, estrogen receptor binding, I-SMAD binding, protein C-terminus binding	Axin-APC-beta-catenin-GSK3B complex, catenin complex, transcription factor complex, perinuclear region of cytoplasm, cell cortex, protein-DNA complex, beta-catenin-TCF7L2 complex, centrosome, cell-substrate adherens junction, lateral plasma membrane	positive regulation of gene-specific transcription from RNA polymerase II promoter, patterning of blood vessels, protein localization at cell surface, positive regulation of heparan sulfate proteoglycan biosynthetic process, negative regulation of cell proliferation, cellular response to indole-3-methanol, response to drug, positive regulation of anti-apoptosis, positive regulation of apoptosis, canonical Wnt receptor signaling pathway, regulation of calcium ion import, androgen receptor signaling pathway, adherens junction assembly, regulation of fibroblast proliferation, epithelial to mesenchymal transition, regulation of smooth muscle cell proliferation, cell-cell adhesion, cellular response to growth factor stimulus, positive regulation of epithelial to mesenchymal transition, regulation of angiogenesis, endothelial tube morphogenesis, negative regulation of apoptosis, transcription, regulation of centriole-centriole cohesion, regulation of centromeric sister chromatid cohesion, response to estradiol stimulus

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	33	SHWQQQSYLDSGIHSGATTTA	GSK-3_group	12051714	LTP	0.30	MOD_GSK3_1	-	-	0.58	-	-
S	37	QQSYLDSGIHSGATTTAPSLS	GSK-3_group	12051714	LTP	0.96	MOD_GSK3_1	-	-	0.62	-	-
T	41	LDSGIHSGATTTAPSLSGKGN	GSK-3_group	12051714	LTP	0.90	MOD_GSK3_1	-	-	0.75	-	-

Substrate:

c-Jun (c-Jun (Transcription factor AP-1))

Seq-ID:

P05412 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14077   DDX21_HUMAN
MINT-68803   VE7_HPV16
MINT-68804   FOS_HUMAN
MINT-6628041   ATF2_HUMAN
MINT-6628056   CITE1_HUMAN
MINT-7148314   MK08_HUMAN
MINT-7148323   MK09_HUMAN
MINT-7148332   MK10_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription repressor activity, R-SMAD binding, RNA polymerase II transcription factor activity, enhancer binding, Rho GTPase activator activity, transcription coactivator activity, promoter binding		SMAD protein nuclear translocation, positive regulation by host of viral transcription, SMAD protein signal transduction, negative regulation of DNA binding, transforming growth factor beta receptor signaling pathway, positive regulation of transcription from RNA polymerase II promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	239	PQTVPEMPGETPPLSPIDMES	GSK-3_group	1956339	LTP	0.27	MOD_GSK3_1	PIN1 WW	Jun	0.90	-	-
T	239	PQTVPEMPGETPPLSPIDMES	GSK-3_group	1846781	LTP	0.27	MOD_GSK3_1	PIN1 WW	Jun	0.90	-	-

Substrate:

c-Myb (Transcription factor)

Seq-ID:

P01103 [Gallus gallus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	nucleus	transcription

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	346	TRTSGDNAPVSCLGEHHHCTP	GSK-3_group	1956339	LTP	0.27	-	-	0.65	-	medium
T	355	VSCLGEHHHCTPSPPVDHGCL	GSK-3_group	1956339	LTP	0.42	-	-	0.55	-	medium
S	357	CLGEHHHCTPSPPVDHGCLPE	GSK-3_group	1956339	LTP	0.27	-	-	0.60	-	medium

Substrate:

c-myc (Myc proto-oncogene protein (c-myc))

Seq-ID:

P01106 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-25075   MAX_HUMAN
MINT-6628157   VE7_HPV16
MINT-7040788   AXN1_HUMAN
MINT-7306800   BIN1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription activator activity, E-box binding, sequence-specific DNA binding transcription factor activity	nucleolus	branching involved in ureteric bud morphogenesis, cellular iron ion homeostasis, cell cycle arrest, response to drug, cell proliferation, positive regulation of metanephric cap mesenchymal cell proliferation, regulation of telomere maintenance

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	58	DIWKKFELLPTPPLSPSRRSG	GSK-3_group	11018017	LTP	1.00	MOD_GSK3_1	-	Myc_N	0.38	-	low
T	58	DIWKKFELLPTPPLSPSRRSG	GSK-3_group	15150404	LTP	1.00	MOD_GSK3_1	-	Myc_N	0.38	-	low

Substrate:

C/EBP alpha (Transcription factor)

Seq-ID:

P53566 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-5225582 FOXO1_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein homodimerization activity, specific RNA polymerase II transcription factor activity, RNA polymerase II transcription factor activity, enhancer binding, transcription factor binding, promoter binding		positive regulation of gene-specific transcription from RNA polymerase II promoter, lung development, macrophage differentiation, transcription, cytokine-mediated signaling pathway, negative regulation of cell proliferation, white fat cell differentiation, cellular response to organic cyclic substance, urea cycle, embryonic placenta development, cell maturation, brown fat cell differentiation, liver development, positive regulation of fat cell differentiation, cellular response to lithium ion, negative regulation of transcription from RNA polymerase II promoter, mitochondrion organization

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	222	TTMHLQPGHPTPPPTPVPSPH	GSK-3_group	10567568	LTP	0.45	MOD_GSK3_1	-	-	0.97	-	low
T	222	TTMHLQPGHPTPPPTPVPSPH	GSK-3_group	12668682	LTP	0.45	MOD_GSK3_1	-	-	0.97	-	low
T	226	LQPGHPTPPPTPVPSPHAAPA	GSK-3_group	10567568	LTP	1.00	MOD_GSK3_1	-	-	0.97	-	low
T	226	LQPGHPTPPPTPVPSPHAAPA	GSK-3_group	12668682	LTP	1.00	MOD_GSK3_1	-	-	0.97	-	low

Substrate:

Calcipressin 1 (Unclassified)

Seq-ID:

P53805 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding transcription factor activity, protein binding	nucleus	central nervous system development, calcium-mediated signaling, blood circulation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	108	PPNPDKQFLISPPASPPVGWK	GSK-3_group	12063245	LTP	0.00	MOD_GSK3_1	-	Calcipressin	0.50	-	low

Substrate:

cAMP-dependent protein kinase type II-alpha regulatory subunit (cAMP-dependent protein kinase type II-alpha regulatory chain)

Seq-ID:

P00515 [Bos taurus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-1779097 CSK21_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cAMP binding, cAMP-dependent protein kinase regulator activity	cAMP-dependent protein kinase complex	signal transduction, regulation of protein amino acid phosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	45	DYFTRLREARSRASTPPAAPP	GSK-3_group	6293815	LTP	0.78	MOD_GSK3_1	-	RIIa	0.68	-	medium
S	48	TRLREARSRASTPPAAPPSGS	GSK-3_group	6293815	LTP	0.39	MOD_GSK3_1	-	-	0.80	-	medium

Substrate:

CREB (cAMP response element binding protein (CREB).)

Seq-ID:

P16220 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-16217   BRCA1_HUMAN
MINT-56642   SGK1_HUMAN
MINT-63231   RECQ5_HUMAN
MINT-63483   VIME_HUMAN
MINT-63485   CHD3_HUMAN
MINT-4979977   CBP_HUMAN
MINT-5209851   EP300_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein dimerization activity, transcription cofactor activity		protein amino acid phosphorylation, signal transduction, interspecies interaction between organisms, response to organic substance

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	129	TDSQKRREILSRRPSYRKILN	GSK-3_group	20541704	LTP	1.00	MOD_GSK3_1	-	pKID	0.56	-	low
S	129	TDSQKRREILSRRPSYRKILN	GSK-3_group	7798217	LTP	1.00	MOD_GSK3_1	-	pKID	0.56	-	low
S	129	TDSQKRREILSRRPSYRKILN	GSK-3_group	15073527	LTP	1.00	MOD_GSK3_1	-	pKID	0.56	-	low

Substrate:

Cyclin D1 (Cyclin D1)

Seq-ID:

P24385 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-50433   CDK4_HUMAN
MINT-50434   CDK6_HUMAN
MINT-50435   MCM10_HUMAN
MINT-50437   CDN1A_HUMAN
MINT-7033534   CDK4_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein kinase binding	cytosol, cyclin-dependent protein kinase holoenzyme complex, nucleoplasm	positive regulation of protein amino acid phosphorylation, cell division, response to UV-A, mitotic cell cycle G1/S DNA damage checkpoint, G1/S transition of mitotic cell cycle, response to drug, positive regulation of cyclin-dependent protein kinase activity

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	286	EEEEEVDLACTPTDVRDVDI	GSK-3_group	9832503	LTP	0.98		-	-	0.49	-	-
T	286	EEEEEVDLACTPTDVRDVDI	GSK-3_group	10766840	LTP	0.98		-	-	0.49	-	-

Substrate:

E-cadherin (Epithelial-cadherin precursor (E-cadherin) (Uvomorulin) (Cadherin-1) (CAM 120/80))

Seq-ID:

P09803 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-46039 GSK3B_RAT

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium ion binding, protein domain specific binding, beta-catenin binding, protein phosphatase binding, RPTP-like protein binding	cell-cell adherens junction, basolateral plasma membrane, integral to membrane, apical part of cell	protein metabolic process, trophectodermal cell differentiation, protein homooligomerization, regulation of branching involved in salivary gland morphogenesis, salivary gland cavitation, homophilic cell adhesion, regulation of caspase activity

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	849	GSGSEAASLSSLNSSESDQDQ	GSK-3_group	10671552	LTP	1.00	MOD_GSK3_1	-	Cadherin_C	0.83	1I7W	103.28%

Substrate:

eIF-2B (Translation initiation factor eIF-2B epsilon subunit (eIF-2B GDP-GTP exchange factor))

Seq-ID:

Q13144 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
guanyl-nucleotide exchange factor activity, translation initiation factor activity, transferase activity, translation initiation factor binding	eukaryotic translation initiation factor 2B complex, nucleus	oligodendrocyte development, myelination, response to heat, negative regulation of translational initiation in response to stress, response to glucose stimulus, astrocyte development, response to peptide hormone stimulus, ovarian follicle development

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	535	SESESEQSMDSEEPDSRGGSP	GSK-3_group	12133000	LTP	0.02		-	-	0.96	-	medium

Substrate:

eIF-2B (Translation initiation factor eIF-2B epsilon subunit (eIF-2B GDP-GTP exchange factor))

Seq-ID:

Q64350 [Rattus norvegicus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
guanyl-nucleotide exchange factor activity, translation initiation factor activity, transferase activity, translation initiation factor binding	eukaryotic translation initiation factor 2B complex	oligodendrocyte development, myelination, response to heat, negative regulation of translational initiation in response to stress, response to glucose stimulus, astrocyte development, response to peptide hormone stimulus, ovarian follicle development

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	535	ERSVDPEELDSRAGSPQLDDI	GSK-3_group	11500362	LTP	1.00	MOD_GSK3_1	-	-	0.65	-	low

Substrate:

glycogen synthase (Glycogen [starch] synthase, muscle)

Seq-ID:

P13834 [Oryctolagus cuniculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
glycogen (starch) synthase activity, protein binding		glycogen biosynthetic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	649	PASVPPSPSLSRHSSPHQSED	GSK-3_group	6772446	LTP	1.00	MOD_GSK3_1	-	Glycogen_syn	0.90	-	low
S	649	PASVPPSPSLSRHSSPHQSED	GSK-3_group	8226927	LTP	1.00	MOD_GSK3_1	-	Glycogen_syn	0.90	-	low

Substrate:

HSF 1 (Transcription factor)

Seq-ID:

Q00613 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-1785958 STUB1_HUMAN
MINT-6743391 STRAP_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding transcription factor activity, protein binding	cytoplasm	transcription, regulation of transcription, DNA-dependent

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	303	PLVRVKEEPPSPPQSPRVEEA	GSK-3_group	12665592	LTP	1.00	MOD_GSK3_1	-	Vert_HS_TF	0.93	-	high

Substrate:

IPP2 (protein phosphatase inhibitor 2 (IPP-2) (from PhosphoBase))

Seq-ID:

P11845 [Oryctolagus cuniculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphoprotein phosphatase inhibitor activity		regulation of phosphoprotein phosphatase activity, regulation of signal transduction, glycogen metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	73	YGLMKIDEPSTPYHSMIGDDD	GSK-3_group	8288648	LTP	1.00	MOD_GSK3_1	-	IPP-2	0.66	-	medium

Substrate:

Mdm2 (Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2. -) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2))

Seq-ID:

P23804 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19799 ARRB1_HUMAN
MINT-7266318 PLK1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
p53 binding, ubiquitin-protein ligase activity	cytoplasm, nucleolus	traversing start control point of mitotic cell cycle, positive regulation of cell cycle

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	240	SGDCLDQDSVSDQFSVEFEVE	GSK-3_group	15610030	LTP	1.00	MOD_GSK3_1	-	-	0.48	-	medium

Substrate:

MLCK (Serine/threonine Kinase)

Seq-ID:

Q15746 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-7250086 NCK1_HUMAN
MINT-7252174 P85A_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
myosin light chain kinase activity, metal ion binding, ATP binding, actin binding, calmodulin binding	cytosol	protein amino acid phosphorylation, muscle contraction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	16	LVASSHISKTSLSVDPSRVDS	GSK-3_group	11964068	LTP	1.00	MOD_GSK3_1	-	-	0.44	-	medium

Substrate:

p53 (Cellular tumor antigen p53)

Seq-ID:

P04637 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13742   CHK2_HUMAN
MINT-15878   UBP7_HUMAN
MINT-16161   BRCA1_HUMAN
MINT-16977   PARP1_HUMAN
MINT-19990   PIN1_HUMAN
MINT-24859   ASPP2_HUMAN
MINT-45889   CEBPZ_HUMAN
MINT-49767   ATM_HUMAN
MINT-50577   SAE1_HUMAN
MINT-56524   SP1_HUMAN
MINT-58470   MED1_HUMAN
MINT-58672   HNRL1_HUMAN
MINT-60094   HIPK2_HUMAN
MINT-61312   MK08_HUMAN
MINT-61317   WWOX_HUMAN
MINT-62206   PP1A_HUMAN
MINT-63290   ARI2_HUMAN
MINT-63365   KITH_HUMAN
MINT-63497   ZNF24_HUMAN
MINT-63537   IF2B_HUMAN
MINT-63547   RAB4A_HUMAN
MINT-63559   SAT1_HUMAN
MINT-64119   STX5_HUMAN
MINT-64188   MD2BP_HUMAN
MINT-64748   K0087_HUMAN
MINT-65132   HSPB1_HUMAN
MINT-65272   MPH6_HUMAN
MINT-68565   BMX_HUMAN
MINT-74886   NPM_HUMAN
MINT-74925   1433Z_HUMAN
MINT-1795431   NMT1_HUMAN
MINT-1891378   CDN1A_HUMAN
MINT-1958329   CHK1_HUMAN
MINT-2634790   RGRF1_HUMAN
MINT-2858243   DVL2_HUMAN
MINT-2866927   SCAM1_HUMAN
MINT-3390028   KC1D_RAT
MINT-3979604   P53_MOUSE
MINT-4049689   NR4A1_HUMAN
MINT-4052116   SYVN1_HUMAN
MINT-4052873   GRP78_HUMAN
MINT-4302642   HS71L_HUMAN
MINT-4303978   XPO1_HUMAN
MINT-4329805   TOPRS_HUMAN
MINT-4793180   EGR1_HUMAN
MINT-4793253   GSK3B_HUMAN
MINT-4793489   PML_HUMAN
MINT-5114724   ZN363_HUMAN
MINT-5207405   HDAC8_HUMAN
MINT-6540866   PSME3_HUMAN
MINT-6540889   MDM2_HUMAN
MINT-6628692   LT_SV40
MINT-6665320   CBP_HUMAN
MINT-6701342   MAP1B_HUMAN
MINT-7013631   PA1_HUMAN
MINT-7013916   RYBP_HUMAN
MINT-7103733   ANDR_HUMAN
MINT-7144912   TOE1_HUMAN
MINT-7222784   FRAP_HUMAN
MINT-7263630   EP300_HUMAN
MINT-7266250   PLK1_HUMAN
MINT-7294020   FAK1_HUMAN
MINT-7295816   IKKB_HUMAN
MINT-7557644   GRP75_HUMAN
MINT-7711943   1433S_HUMAN
MINT-7717378   PHB_HUMAN
MINT-7718917   SNAI1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription activator activity, protease binding, DNA strand annealing activity, chromatin binding, copper ion binding, ATP binding, transcription factor binding, chaperone binding, zinc ion binding, histone acetyltransferase binding, promoter binding, sequence-specific DNA binding transcription factor activity, protein N-terminus binding, protein heterodimerization activity, protein phosphatase 2A binding, protein kinase binding, ubiquitin protein ligase binding	nucleolus, nuclear matrix, insoluble fraction, protein complex, endoplasmic reticulum, PML body, mitochondrion	positive regulation of gene-specific transcription from RNA polymerase II promoter, senescence, mitotic cell cycle G1/S DNA damage checkpoint, cell cycle arrest, regulation of mitochondrial membrane permeability, response to gamma radiation, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, response to tumor cell, ER overload response, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, interspecies interaction between organisms, Ras protein signal transduction, nucleotide-excision repair, protein tetramerization, cellular response to glucose starvation, negative regulation of helicase activity, negative regulation of cell growth, base-excision repair, activation of caspase activity by cytochrome c, cell aging

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	33	WKLLPENNVLSPLPSQAMDDL	GSK-3_group	11483158	LTP	0.88	MOD_GSK3_1	PIN1 WW	-	0.56	-	-