List of substrates found:


Substrate: Beta-2 adrenergic receptor (Protein G coupled receptor)
Seq-ID: P04274 [Mesocricetus auratus]
Download:fasta csv
Interaction Network(s): -
External Source(s):
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein homodimerization activity,
norepinephrine binding,
beta2-adrenergic receptor activity		 plasma membrane,
receptor complex,
integral to membrane		 positive regulation of MAPKKK cascade,
receptor-mediated endocytosis,
activation of adenylate cyclase activity,
desensitization of G-protein coupled receptor protein signaling pathway by arrestin
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 132 ETLCVIAVDRYIAITSPFKYQ INSR 8557631
LTP
1.00
 - 7tm_1
0.01
 - medium
Y 141 RYIAITSPFKYQSLLTKNKAR INSR 8557631
LTP
1.00
 - 7tm_1
0.02
 - medium
Y 350 LCLRRSSSKAYGNGYSSNSNG INSR 8557631
LTP
0.10
 GRB2 SH2 -
0.30
 - medium
Y 354 RSSSKAYGNGYSSNSNGKTDY INSR 8557631
LTP
0.08
 - -
0.42
 - medium
Y 364 YSSNSNGKTDYMGEASGCQLG INSR 8557631
LTP
0.15
 - -
0.39
 - medium

Substrate: BLVRA (Biliverdin reductase)
Seq-ID: P53004 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
biliverdin reductase activity,
zinc ion binding		 cytoplasm oxidation reduction,
heme catabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 198 ATLEERKEDQYMKMTVCLETE INSR 15870194
LTP
0.17
 - Biliv-reduc_cat
0.32
 2H63 38.86%
Y 228 EKGPGLKRNRYLSFHFKSGSL INSR 15870194
LTP
0.07
 - Biliv-reduc_cat
0.20
 2H63 32.31%
Y 291 CLGLAEEIQKYCCSRK      INSR 15870194
LTP
0.08
 - -
0.09
 2H63 37.12%

Substrate: Calmodulin (Calmodulin)
Seq-ID: P62158 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-48052   IKKA_HUMAN
MINT-48084   IKKB_HUMAN
MINT-48113   IKKE_HUMAN
MINT-48186   NEMO_HUMAN
MINT-48261   TANK_HUMAN
MINT-48323   M3K1_HUMAN
MINT-48456   M3K3_HUMAN
MINT-48670   NFKB1_HUMAN
MINT-48738   NFKB2_HUMAN
MINT-48841   M3K14_HUMAN
MINT-49007   RELB_HUMAN
MINT-49067   RIPK2_HUMAN
MINT-49173   TAB1_HUMAN
MINT-49204   TAB2_HUMAN
MINT-49274   TBK1_HUMAN
MINT-49428   TNR1B_HUMAN
MINT-51638   CRFR1_HUMAN
MINT-58232   CANB1_HUMAN
MINT-58242   FKBP8_HUMAN
MINT-67316   K1683_HUMAN
MINT-3295975   1433Z_HUMAN
MINT-5114562   ZN363_HUMAN
MINT-6595938   MYO10_HUMAN
MINT-7148437   THOP1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
thioesterase binding,
N-terminal myristoylation domain binding,
calcium ion binding,
protein domain specific binding,
titin binding		 centrosome,
plasma membrane,
extracellular region,
spindle microtubule,
cytosol,
spindle pole,
nucleoplasm		 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum,
muscle contraction,
regulation of cytokinesis,
response to calcium ion,
negative regulation of ryanodine-sensitive calcium-release channel activity,
positive regulation of ryanodine-sensitive calcium-release channel activity,
G-protein coupled receptor protein signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 100 FRVFDKDGNGYISAAELRHVM INSR 8639568
LTP
0.46
 - EFh
0.31
 1FW4 36.68%
Y 100 FRVFDKDGNGYISAAELRHVM INSR 2843348
LTP
0.46
 - EFh
0.31
 1FW4 36.68%

Substrate: CBL E3 ubiquitin protein ligase (Adaptor molecule)
Seq-ID: P22681 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-15516   LCK_HUMAN
MINT-15716   CRK_HUMAN
MINT-16022   CD2AP_HUMAN
MINT-16347   LYN_HUMAN
MINT-16846   LCP2_HUMAN
MINT-17062   FCGR1_HUMAN
MINT-17932   NCK1_HUMAN
MINT-50666   FYN_HUMAN
MINT-50717   ABL1_HUMAN
MINT-50722   CRKL_HUMAN
MINT-58331   ITCH_HUMAN
MINT-60970   RET_HUMAN
MINT-60973   EGFR_HUMAN
MINT-60978   SHC1_HUMAN
MINT-68500   P85A_HUMAN
MINT-2837344   PLCG1_BOVIN
MINT-4299918   ASAP1_HUMAN
MINT-6169713   SPY1_HUMAN
MINT-6170244   SH3G2_HUMAN
MINT-6538940   SPY4_HUMAN
MINT-6538977   KSYK_HUMAN
MINT-6539587   MET_HUMAN
MINT-6539601   SPY2_HUMAN
MINT-6539646   VGFR1_HUMAN
MINT-6539679   RON_HUMAN
MINT-6539730   SRC_HUMAN
MINT-7040249   GRB2_HUMAN
MINT-7046364   ITSN1_HUMAN
MINT-7103623   MK08_HUMAN
MINT-7211864   ARHG7_HUMAN
MINT-7214822   FYN_MOUSE
MINT-7218352   SH3K1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
calcium ion binding,
zinc ion binding,
sequence-specific DNA binding transcription factor activity,
signal transducer activity,
ubiquitin-protein ligase activity		 cytosol,
nucleus		 epidermal growth factor receptor signaling pathway,
positive regulation of receptor-mediated endocytosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 371 IKVTQEQYELYCEMGSTFQLC INSR 11997497
LTP
1.00
 PIK3R1 SH2 -
0.11
 1FBV 5.24%
Y 700 EQCEGEEDTEYMTPSSRPLRP INSR 11997497
LTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --

Substrate: Fatty acid-binding protein, adipocyte (Chaperone)
Seq-ID: P04117 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription repressor activity,
lipid binding,
transporter activity		 nucleus cholesterol homeostasis,
white fat cell differentiation,
cytokine production,
brown fat cell differentiation,
positive regulation of inflammatory response,
cellular response to lithium ion,
negative regulation of protein kinase activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 20 KLVSSENFDDYMKEVGVGFAT INSR 1956339
LTP
1.00
 - Lipocalin
0.17
 1AB0 4.80%

Substrate: Gab1 (Multisubstrate docking protein downstream in the signaling pathways of different RTK.)
Seq-ID: Q13480 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-58395   GRB2_HUMAN
MINT-58403   GRAP2_HUMAN
MINT-58404   MET_HUMAN
MINT-68564   BMX_HUMAN
MINT-1893011   P85A_HUMAN
MINT-6169406   PTN11_HUMAN
MINT-6169502   PAXI_HUMAN
MINT-7971128   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3/SH2 adaptor activity cytosol epidermal growth factor receptor signaling pathway,
insulin receptor signaling pathway,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 242 MNGFFQQQMIYDSPPSRAPSA INSR 10978177
LTP
1.00
 CRKL SH2;
CRK SH2;
NCK SH2		 -
0.65
 - low
Y 373 PRTASDTDSSYCIPTAGMSPS INSR 10978177
LTP
0.08
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.66
 - low
Y 447 SVSSEELDENYVPMNPNSPPR INSR 10978177
LTP
1.00
 PIK3R1 SH2;
PIK3R2 SH2;
PTPN11 SH2		 -
0.83
 - low
Y 472 SFTEPIQEANYVPMTPGTFDF INSR 10978177
LTP
1.00
 PIK3R1 SH2;
PIK3R2 SH2		 -
0.54
 - low
Y 589 SSDSHDSEENYVPMNPNLSSE INSR 10978177
LTP
1.00
 PIK3R1 SH2;
PTPN11 SH2		 -
0.89
 - low
Y 627 IKPKGDKQVEYLDLDLDSGKS INSR 10978177
LTP
1.00
 PTPN11 SH2 -
0.72
 - low

Substrate: Insulin R (Receptor tyrosine kinase)
Seq-ID: P06213 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16516   GRB10_HUMAN
MINT-16842   MD2L1_HUMAN
MINT-18199   IRS2_HUMAN
MINT-19010   IRS1_HUMAN
MINT-73466   GRB10_MOUSE
MINT-6793537   INSR_RAT
MINT-6794075   IRS1_MOUSE
MINT-6794090   INSR_MOUSE
MINT-6794946   PTN1_HUMAN
MINT-6795115   IRS1_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
insulin-like growth factor receptor binding,
insulin binding,
PTB domain binding,
GTP binding,
metal ion binding,
insulin receptor substrate binding,
ATP binding,
insulin-like growth factor I binding,
insulin receptor activity,
SH2 domain binding,
phosphoinositide 3-kinase binding,
insulin-like growth factor II binding,
receptor signaling protein tyrosine kinase activity		 microsome,
caveola,
insulin receptor complex,
endosome membrane		 positive regulation of glycolysis,
positive regulation of MAPKKK cascade,
positive regulation of developmental growth,
regulation of embryonic development,
heart morphogenesis,
positive regulation of cell migration,
carbohydrate metabolic process,
protein heterotetramerization,
positive regulation of protein kinase B signaling cascade,
protein amino acid autophosphorylation,
activation of MAPK activity,
positive regulation of glycogen biosynthetic process,
positive regulation of mitosis,
peptidyl-tyrosine phosphorylation,
positive regulation of glucose import,
positive regulation of respiratory burst,
activation of protein kinase B activity,
G-protein coupled receptor protein signaling pathway,
positive regulation of DNA replication,
positive regulation of protein amino acid phosphorylation,
positive regulation of cell proliferation,
glucose homeostasis,
positive regulation of nitric oxide biosynthetic process,
transformation of host cell by virus,
regulation of gene-specific transcription
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 992 RQPDGPLGPLYASSNPEYLSA INSR 1658004
LTP
1.00
 GRB2 SH2 -
0.33
 --
Y 999 GPLYASSNPEYLSASDVFPCS INSR 8662806
LTP
1.00
 CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2		 -
0.11
 --
Y 999 GPLYASSNPEYLSASDVFPCS INSR 1658004
LTP
1.00
 CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2		 -
0.11
 --
Y 999 GPLYASSNPEYLSASDVFPCS INSR 10340378
LTP
1.00
 CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2		 -
0.11
 --
Y 1011 SASDVFPCSVYVPDEWEVSRE INSR 12707268
LTP
0.06
 GRB2 SH2 -
0.11
 1IR3 77.98%
Y 1185 IGDFGMTRDIYETDYYRKGGK INSR 7806540
LTP
1.00
 GRB10 SH2;
GRB14 SH2;
PTPN11 SH2;
SH2B1 SH2;
SH2B2 SH2		 TyrKc
0.19
 1IR3 100.87%
Y 1189 GMTRDIYETDYYRKGGKGLLP INSR 7806540
LTP
1.00
 GRB10 SH2;
GRB14 SH2;
PTPN11 SH2;
SH2B1 SH2;
SH2B2 SH2		 TyrKc
0.19
 1IR3 67.69%
Y 1190 MTRDIYETDYYRKGGKGLLPV INSR 7806540
LTP
1.00
 GRB10 SH2;
PTPN11 SH2;
SH2B1 SH2		 TyrKc
0.17
 1IR3 44.54%
Y 1355 GGSSLGFKRSYEEHIPYTHMN INSR 1321605
LTP
0.85
 GRB10 SH2;
PIK3R1 SH2		 -
0.50
 --
Y 1361 FKRSYEEHIPYTHMNGGKKNG INSR 1321605
LTP
0.95
 Csk SH2;
GRB10 SH2;
PIK3R1 SH2;
PTPN11 SH2;
SHC1 SH2		 -
0.54
 --

Substrate: Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID: P35570 [Rattus norvegicus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-45938   ITB2_HUMAN
MINT-45939   ITB3_HUMAN
MINT-60761   INSR_RAT
MINT-6762786   GRB2_HUMAN
MINT-6762811   PTN11_HUMAN
MINT-6762830   PTPRA_HUMAN
MINT-6762866   PTN1_HUMAN
MINT-6762880   P85A_HUMAN
MINT-6762904   CRK_HUMAN
MINT-6795115   INSR_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoinositide 3-kinase binding,
protein kinase C binding,
insulin-like growth factor receptor binding,
insulin-like growth factor receptor activity,
insulin receptor binding,
transmembrane receptor protein tyrosine kinase docking protein activity,
SH2 domain binding		 microsome,
cytosol,
insulin receptor complex,
nucleus		 negative regulation of insulin receptor signaling pathway,
negative regulation of somatostatin secretion,
positive regulation of insulin receptor signaling pathway,
negative regulation of insulin secretion,
protein heterooligomerization,
insulin receptor signaling pathway,
positive regulation of phosphoinositide 3-kinase activity,
positive regulation of phosphorylation,
positive regulation of glucagon secretion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 460 PARGEEELSNYICMGGKGAST INSR 7504175
LTP
1.00
 - -
0.58
 - medium
Y 608 DSSNLHTDDGYMPMSPGVAPV INSR 7504175
LTP
1.00
 PIK3R1 SH2 -
0.79
 - medium
Y 608 DSSNLHTDDGYMPMSPGVAPV INSR 11572799
LTP
1.00
 PIK3R1 SH2 -
0.79
 - medium
Y 628 VPSNRKGNGDYMPMSPKSVSA INSR 7504175
LTP
1.00
 PIK3R1 SH2 -
0.81
 - medium
Y 628 VPSNRKGNGDYMPMSPKSVSA INSR 11572799
LTP
1.00
 PIK3R1 SH2 -
0.81
 - medium
Y 895 HPPEPKSPGEYVNIEFGSGQP INSR 7504175
LTP
1.00
 GRB2 SH2 -
0.80
 - medium
Y 895 HPPEPKSPGEYVNIEFGSGQP INSR 8530377
LTP
1.00
 GRB2 SH2 -
0.80
 - medium
Y 939 APREETGSEEYMNMDLGPGRR INSR 7504175
LTP
1.00
 PIK3R1 SH2 -
0.87
 - medium
Y 939 APREETGSEEYMNMDLGPGRR INSR 11572799
LTP
1.00
 PIK3R1 SH2 -
0.87
 - medium
Y 987 TRSVPNSRGDYMTMQIGCPRQ INSR 7504175
LTP
0.16
 - -
0.64
 - medium
Y 987 TRSVPNSRGDYMTMQIGCPRQ INSR 11572799
LTP
0.16
 - -
0.64
 - medium
Y 1172 AAGGLEKSLNYIDLDLVKDVK INSR 7504175
LTP
1.00
 PTPN11 SH2 -
0.48
 - medium
Y 1172 AAGGLEKSLNYIDLDLVKDVK INSR 11572799
LTP
1.00
 PTPN11 SH2 -
0.48
 - medium
Y 1222 PRRSSEDLSTYASINFQKQPE INSR 7504175
LTP
0.09
 PTPN11 SH2 -
0.77
 - medium

Substrate: Insulin receptor substrate 2 (Adaptor molecule)
Seq-ID: P81122 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-58556   NUCL_MOUSE
MINT-58581   ZN592_MOUSE
MINT-58761   LYN_MOUSE
MINT-60762   INSR_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein kinase binding,
signal transducer activity		 cytosol brain development,
negative regulation of kinase activity,
positive regulation of insulin secretion,
positive regulation of mesenchymal cell proliferation,
positive regulation of B cell proliferation,
positive regulation of cell migration,
response to glucose stimulus,
mammary gland development,
negative regulation of B cell apoptosis,
insulin receptor signaling pathway,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 624 ASSPKVAYNPYPEDYGDIEIG INSR 9195949
LTP
1.00
 - -
0.54
 - medium
Y 628 KVAYNPYPEDYGDIEIGSHKS INSR 9195949
LTP
0.15
 - -
0.56
 - medium

Substrate: p62DOK (Docking protein, common target of PTKs)
Seq-ID: Q99704 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-74512   ERBB2_HUMAN
MINT-7974670   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
insulin receptor binding cytosol,
perinuclear region of cytoplasm		 transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 362 KLTDPKEDPIYDEPEGLAPVP INSR 11551902
LTP
1.00
 ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2		 -
0.82
 --
Y 398 WCQARVKEEGYELPYNPATDD INSR 11551902
LTP
0.17
 ABL1 SH2;
CRKL SH2;
RASA_group SH2		 -
0.48
 --

Substrate: PI3-kinase p85-alpha subunit (Adaptor molecule. Phopshatidylinositol 3-kinase regulatory alpha subunit.)
Seq-ID: P27986 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16109   ARAF_HUMAN
MINT-17501   SHC1_HUMAN
MINT-19009   CDC42_HUMAN
MINT-56732   KSYK_HUMAN
MINT-56734   KSYK_MOUSE
MINT-65974   GRB2_HUMAN
MINT-66003   LCK_HUMAN
MINT-68496   GAB2_HUMAN
MINT-68500   CBL_HUMAN
MINT-68735   IRS1_HUMAN
MINT-74606   EGFR_HUMAN
MINT-74610   ERBB2_HUMAN
MINT-74617   ERBB3_HUMAN
MINT-1893011   GAB1_HUMAN
MINT-2840114   TLR3_HUMAN
MINT-3378272   SEPT2_HUMAN
MINT-6762880   IRS1_RAT
MINT-7103574   FLT3_HUMAN
MINT-7103638   MK08_HUMAN
MINT-7103655   CRKL_HUMAN
MINT-7251262   ICAL_HUMAN
MINT-7251286   SNX17_HUMAN
MINT-7251334   DAB2_HUMAN
MINT-7251346   CDC27_HUMAN
MINT-7251370   FLNA_HUMAN
MINT-7251382   SYNJ2_HUMAN
MINT-7251406   CSDE1_HUMAN
MINT-7251418   ABL1_HUMAN
MINT-7251430   SUV92_HUMAN
MINT-7251442   VP13A_HUMAN
MINT-7251454   FLNB_HUMAN
MINT-7251526   SOS1_HUMAN
MINT-7251538   ASAP2_HUMAN
MINT-7251550   LIPA3_HUMAN
MINT-7251562   AKAP2_HUMAN
MINT-7251574   ARHGB_HUMAN
MINT-7251598   PHAR2_HUMAN
MINT-7251610   DLGP4_HUMAN
MINT-7251622   ELK3_HUMAN
MINT-7251658   BRCA1_HUMAN
MINT-7251706   CKAP5_HUMAN
MINT-7251718   RRAS_HUMAN
MINT-7251730   ECT2_HUMAN
MINT-7251754   TPX2_HUMAN
MINT-7251766   JAK2_HUMAN
MINT-7251778   ASAP1_HUMAN
MINT-7251790   FLNC_HUMAN
MINT-7251802   DNLI3_HUMAN
MINT-7251814   TGON2_HUMAN
MINT-7251838   SHAN2_HUMAN
MINT-7251850   KI13A_HUMAN
MINT-7251862   ABL2_HUMAN
MINT-7251886   BRPF3_HUMAN
MINT-7251898   SH3K1_HUMAN
MINT-7251934   MYRIP_HUMAN
MINT-7251982   DAG1_HUMAN
MINT-7251994   STF1_HUMAN
MINT-7252006   P3C2B_HUMAN
MINT-7252018   SNX8_HUMAN
MINT-7252030   BRD4_HUMAN
MINT-7252078   MINT_HUMAN
MINT-7252126   PLCG2_HUMAN
MINT-7252150   MAP4_HUMAN
MINT-7252174   MYLK_HUMAN
MINT-7252186   PEBP1_HUMAN
MINT-7252234   CAF1A_HUMAN
MINT-7252258   DTBP1_HUMAN
MINT-7252270   NELFB_HUMAN
MINT-7252282   AKAP6_HUMAN
MINT-7252294   FANCA_HUMAN
MINT-7252318   GHR_HUMAN
MINT-7252330   M4K1_HUMAN
MINT-7252342   RPGF1_HUMAN
MINT-7296136   SRC_HUMAN
MINT-7306624   LCP2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
ErbB-3 class receptor binding,
insulin-like growth factor receptor binding,
phosphoinositide 3-kinase regulator activity,
insulin binding,
insulin receptor binding,
insulin receptor substrate binding,
phosphatidylinositol binding,
protein phosphatase binding		 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex phosphoinositide 3-kinase cascade,
insulin-like growth factor receptor signaling pathway,
phosphoinositide phosphorylation,
interspecies interaction between organisms,
positive regulation of establishment of protein localization in plasma membrane,
insulin receptor signaling pathway,
positive regulation of glucose import,
growth hormone receptor signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 368 RDASTKMHGDYTLTLRKGGNN INSR 8385099
LTP
0.95
 - SH2
0.45
 2IUG 6.99%
Y 580 LIQLRKTRDQYLMWLTQKGVR INSR 8385099
LTP
1.00
 - -
0.29
 2RD0 55.02%
Y 607 WLGNENTEDQYSLVEDDEDLP INSR 8385099
LTP
1.00
 - -
0.55
 --

Substrate: Tyrosine-protein phosphatase, non-receptor type 1 (Protein tyrosine phosphatase 1B)
Seq-ID: P18031 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-51115   PPIP1_HUMAN
MINT-73489   CADH2_HUMAN
MINT-6744190   CSK21_HUMAN
MINT-6761890   GSK3B_HUMAN
MINT-6761899   ESR1_HUMAN
MINT-6762163   IKBA_HUMAN
MINT-6762380   PGFRB_HUMAN
MINT-6762549   PAXI_MOUSE
MINT-6762573   FAK1_MOUSE
MINT-6762866   IRS1_RAT
MINT-6763504   BCAR1_MOUSE
MINT-6763556   INSR_RAT
MINT-6764602   JAK2_HUMAN
MINT-6764613   STAT3_HUMAN
MINT-6764665   TRPV6_HUMAN
MINT-6764866   CAV1_HUMAN
MINT-6765163   PIAS1_HUMAN
MINT-6765185   SUMO1_HUMAN
MINT-6765318   CTND1_MOUSE
MINT-6765333   LPP_MOUSE
MINT-6765355   SRC8_MOUSE
MINT-6765370   ZO1_MOUSE
MINT-6765383   PLCG1_MOUSE
MINT-6765422   DOK1_MOUSE
MINT-6765439   EGFR_MOUSE
MINT-6765460   PGFRB_MOUSE
MINT-6787689   MET_HUMAN
MINT-6787710   ABL1_HUMAN
MINT-6793324   B3AT_HUMAN
MINT-6793358   EGFR_HUMAN
MINT-6793387   CAN1_HUMAN
MINT-6793394   CAN2_HUMAN
MINT-6793439   IRS1_MOUSE
MINT-6793452   INSR_MOUSE
MINT-6793484   BCAR1_HUMAN
MINT-6793722   AKT1_MOUSE
MINT-6793745   IRS1_HUMAN
MINT-6793782   TYK2_HUMAN
MINT-6793941   NTRK1_HUMAN
MINT-6793957   NTRK3_HUMAN
MINT-6793973   LTK_HUMAN
MINT-6793989   STA5A_HUMAN
MINT-6794005   STA5B_HUMAN
MINT-6794135   LAT_HUMAN
MINT-6794748   EPOR_HUMAN
MINT-6794792   GRB2_HUMAN
MINT-6794817   ITB3_HUMAN
MINT-6794878   ACTS_HUMAN
MINT-6794892   FAK1_HUMAN
MINT-6794946   INSR_HUMAN
MINT-6794972   KPCG_HUMAN
MINT-6795050   JAK2_MOUSE
MINT-6795199   SRC8_HUMAN
MINT-6795447   SRC_HUMAN
MINT-6796717   PLD2_HUMAN
MINT-6797067   CLK2_HUMAN
MINT-6797829   GHR_HUMAN
MINT-6799814   ROS_HUMAN
MINT-6800783   IGF1R_HUMAN
MINT-7972220   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein tyrosine phosphatase activity,
zinc ion binding		 cytosol,
endoplasmic reticulum membrane		 negative regulation of insulin receptor signaling pathway,
signal transduction
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 152 LTLISEDIKSYYTVRQLELEN INSR 11106648
LTP
0.95
 - PTPc_DSPc
0.14
 2CM2 56.33%
Y 153 TLISEDIKSYYTVRQLELENL INSR 11106648
LTP
1.00
 - PTPc_DSPc
0.17
 2CM2 13.10%

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