List of substrates found:


Substrate: Beta-2 adrenergic receptor (Protein G coupled receptor)
Seq-ID: P04274 [Mesocricetus auratus]
Download:fasta csv
Interaction Network(s): -
External Source(s):
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 132 ETLCVIAVDRYIAITSPFKYQ INSR 8557631
LTP
1.00
- 7tm_1
0.01
- medium
Y 141 RYIAITSPFKYQSLLTKNKAR INSR 8557631
LTP
1.00
- 7tm_1
0.02
- medium
Y 350 LCLRRSSSKAYGNGYSSNSNG INSR 8557631
LTP
0.10
GRB2 SH2 -
0.30
- medium
Y 354 RSSSKAYGNGYSSNSNGKTDY INSR 8557631
LTP
0.08
- -
0.42
- medium
Y 364 YSSNSNGKTDYMGEASGCQLG INSR 8557631
LTP
0.15
- -
0.39
- medium

Substrate: BLVRA (Biliverdin reductase)
Seq-ID: P53004 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 198 ATLEERKEDQYMKMTVCLETE INSR 15870194
LTP
0.17
- Biliv-reduc_cat
0.32
2H63 38.86%
Y 228 EKGPGLKRNRYLSFHFKSGSL INSR 15870194
LTP
0.07
- Biliv-reduc_cat
0.20
2H63 32.31%
Y 291 CLGLAEEIQKYCCSRK      INSR 15870194
LTP
0.08
- -
0.09
2H63 37.12%

Substrate: Calmodulin (Calmodulin)
Seq-ID: P62158 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 100 FRVFDKDGNGYISAAELRHVM INSR 8639568
LTP
0.46
- EFh
0.31
1FW4 36.68%
Y 100 FRVFDKDGNGYISAAELRHVM INSR 2843348
LTP
0.46
- EFh
0.31
1FW4 36.68%

Substrate: CBL E3 ubiquitin protein ligase (Adaptor molecule)
Seq-ID: P22681 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 371 IKVTQEQYELYCEMGSTFQLC INSR 11997497
LTP
1.00
PIK3R1 SH2 -
0.11
1FBV 5.24%
Y 700 EQCEGEEDTEYMTPSSRPLRP INSR 11997497
LTP
0.63
CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2
-
0.85
--

Substrate: Fatty acid-binding protein, adipocyte (Chaperone)
Seq-ID: P04117 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 20 KLVSSENFDDYMKEVGVGFAT INSR 1956339
LTP
1.00
- Lipocalin
0.17
1AB0 4.80%

Substrate: Gab1 (Multisubstrate docking protein downstream in the signaling pathways of different RTK.)
Seq-ID: Q13480 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 242 MNGFFQQQMIYDSPPSRAPSA INSR 10978177
LTP
1.00
CRKL SH2;
CRK SH2;
NCK SH2
-
0.65
- low
Y 373 PRTASDTDSSYCIPTAGMSPS INSR 10978177
LTP
0.08
CRKL SH2;
CRK SH2;
PLCG1 SH2
-
0.66
- low
Y 447 SVSSEELDENYVPMNPNSPPR INSR 10978177
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2;
PTPN11 SH2
-
0.83
- low
Y 472 SFTEPIQEANYVPMTPGTFDF INSR 10978177
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2
-
0.54
- low
Y 589 SSDSHDSEENYVPMNPNLSSE INSR 10978177
LTP
1.00
PIK3R1 SH2;
PTPN11 SH2
-
0.89
- low
Y 627 IKPKGDKQVEYLDLDLDSGKS INSR 10978177
LTP
1.00
PTPN11 SH2 -
0.72
- low

Substrate: Insulin R (Receptor tyrosine kinase)
Seq-ID: P06213 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 992 RQPDGPLGPLYASSNPEYLSA INSR 1658004
LTP
1.00
GRB2 SH2 -
0.33
--
Y 999 GPLYASSNPEYLSASDVFPCS INSR 8662806
LTP
1.00
CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2
-
0.11
--
Y 999 GPLYASSNPEYLSASDVFPCS INSR 1658004
LTP
1.00
CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2
-
0.11
--
Y 999 GPLYASSNPEYLSASDVFPCS INSR 10340378
LTP
1.00
CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2
-
0.11
--
Y 1011 SASDVFPCSVYVPDEWEVSRE INSR 12707268
LTP
0.06
GRB2 SH2 -
0.11
1IR3 77.98%
Y 1185 IGDFGMTRDIYETDYYRKGGK INSR 7806540
LTP
1.00
GRB10 SH2;
GRB14 SH2;
PTPN11 SH2;
SH2B1 SH2;
SH2B2 SH2
TyrKc
0.19
1IR3 100.87%
Y 1189 GMTRDIYETDYYRKGGKGLLP INSR 7806540
LTP
1.00
GRB10 SH2;
GRB14 SH2;
PTPN11 SH2;
SH2B1 SH2;
SH2B2 SH2
TyrKc
0.19
1IR3 67.69%
Y 1190 MTRDIYETDYYRKGGKGLLPV INSR 7806540
LTP
1.00
GRB10 SH2;
PTPN11 SH2;
SH2B1 SH2
TyrKc
0.17
1IR3 44.54%
Y 1355 GGSSLGFKRSYEEHIPYTHMN INSR 1321605
LTP
0.85
GRB10 SH2;
PIK3R1 SH2
-
0.50
--
Y 1361 FKRSYEEHIPYTHMNGGKKNG INSR 1321605
LTP
0.95
Csk SH2;
GRB10 SH2;
PIK3R1 SH2;
PTPN11 SH2;
SHC1 SH2
-
0.54
--

Substrate: Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID: P35570 [Rattus norvegicus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 460 PARGEEELSNYICMGGKGAST INSR 7504175
LTP
1.00
- -
0.58
- medium
Y 608 DSSNLHTDDGYMPMSPGVAPV INSR 7504175
LTP
1.00
PIK3R1 SH2 -
0.79
- medium
Y 608 DSSNLHTDDGYMPMSPGVAPV INSR 11572799
LTP
1.00
PIK3R1 SH2 -
0.79
- medium
Y 628 VPSNRKGNGDYMPMSPKSVSA INSR 7504175
LTP
1.00
PIK3R1 SH2 -
0.81
- medium
Y 628 VPSNRKGNGDYMPMSPKSVSA INSR 11572799
LTP
1.00
PIK3R1 SH2 -
0.81
- medium
Y 895 HPPEPKSPGEYVNIEFGSGQP INSR 7504175
LTP
1.00
GRB2 SH2 -
0.80
- medium
Y 895 HPPEPKSPGEYVNIEFGSGQP INSR 8530377
LTP
1.00
GRB2 SH2 -
0.80
- medium
Y 939 APREETGSEEYMNMDLGPGRR INSR 7504175
LTP
1.00
PIK3R1 SH2 -
0.87
- medium
Y 939 APREETGSEEYMNMDLGPGRR INSR 11572799
LTP
1.00
PIK3R1 SH2 -
0.87
- medium
Y 987 TRSVPNSRGDYMTMQIGCPRQ INSR 7504175
LTP
0.16
- -
0.64
- medium
Y 987 TRSVPNSRGDYMTMQIGCPRQ INSR 11572799
LTP
0.16
- -
0.64
- medium
Y 1172 AAGGLEKSLNYIDLDLVKDVK INSR 7504175
LTP
1.00
PTPN11 SH2 -
0.48
- medium
Y 1172 AAGGLEKSLNYIDLDLVKDVK INSR 11572799
LTP
1.00
PTPN11 SH2 -
0.48
- medium
Y 1222 PRRSSEDLSTYASINFQKQPE INSR 7504175
LTP
0.09
PTPN11 SH2 -
0.77
- medium

Substrate: Insulin receptor substrate 2 (Adaptor molecule)
Seq-ID: P81122 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 624 ASSPKVAYNPYPEDYGDIEIG INSR 9195949
LTP
1.00
- -
0.54
- medium
Y 628 KVAYNPYPEDYGDIEIGSHKS INSR 9195949
LTP
0.15
- -
0.56
- medium

Substrate: p62DOK (Docking protein, common target of PTKs)
Seq-ID: Q99704 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
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Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 362 KLTDPKEDPIYDEPEGLAPVP INSR 11551902
LTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2
-
0.82
--
Y 398 WCQARVKEEGYELPYNPATDD INSR 11551902
LTP
0.17
ABL1 SH2;
CRKL SH2;
RASA_group SH2
-
0.48
--

Substrate: PI3-kinase p85-alpha subunit (Adaptor molecule. Phopshatidylinositol 3-kinase regulatory alpha subunit.)
Seq-ID: P27986 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16109   ARAF_HUMAN
MINT-17501   SHC1_HUMAN
MINT-19009   CDC42_HUMAN
MINT-56732   KSYK_HUMAN
MINT-56734   KSYK_MOUSE
MINT-65974   GRB2_HUMAN
MINT-66003   LCK_HUMAN
MINT-68496   GAB2_HUMAN
MINT-68500   CBL_HUMAN
MINT-68735   IRS1_HUMAN
MINT-74606   EGFR_HUMAN
MINT-74610   ERBB2_HUMAN
MINT-74617   ERBB3_HUMAN
MINT-1893011   GAB1_HUMAN
MINT-2840114   TLR3_HUMAN
MINT-3378272   SEPT2_HUMAN
MINT-6762880   IRS1_RAT
MINT-7103574   FLT3_HUMAN
MINT-7103638   MK08_HUMAN
MINT-7103655   CRKL_HUMAN
MINT-7251262   ICAL_HUMAN
MINT-7251286   SNX17_HUMAN
MINT-7251334   DAB2_HUMAN
MINT-7251346   CDC27_HUMAN
MINT-7251370   FLNA_HUMAN
MINT-7251382   SYNJ2_HUMAN
MINT-7251406   CSDE1_HUMAN
MINT-7251418   ABL1_HUMAN
MINT-7251430   SUV92_HUMAN
MINT-7251442   VP13A_HUMAN
MINT-7251454   FLNB_HUMAN
MINT-7251526   SOS1_HUMAN
MINT-7251538   ASAP2_HUMAN
MINT-7251550   LIPA3_HUMAN
MINT-7251562   AKAP2_HUMAN
MINT-7251574   ARHGB_HUMAN
MINT-7251598   PHAR2_HUMAN
MINT-7251610   DLGP4_HUMAN
MINT-7251622   ELK3_HUMAN
MINT-7251658   BRCA1_HUMAN
MINT-7251706   CKAP5_HUMAN
MINT-7251718   RRAS_HUMAN
MINT-7251730   ECT2_HUMAN
MINT-7251754   TPX2_HUMAN
MINT-7251766   JAK2_HUMAN
MINT-7251778   ASAP1_HUMAN
MINT-7251790   FLNC_HUMAN
MINT-7251802   DNLI3_HUMAN
MINT-7251814   TGON2_HUMAN
MINT-7251838   SHAN2_HUMAN
MINT-7251850   KI13A_HUMAN
MINT-7251862   ABL2_HUMAN
MINT-7251886   BRPF3_HUMAN
MINT-7251898   SH3K1_HUMAN
MINT-7251934   MYRIP_HUMAN
MINT-7251982   DAG1_HUMAN
MINT-7251994   STF1_HUMAN
MINT-7252006   P3C2B_HUMAN
MINT-7252018   SNX8_HUMAN
MINT-7252030   BRD4_HUMAN
MINT-7252078   MINT_HUMAN
MINT-7252126   PLCG2_HUMAN
MINT-7252150   MAP4_HUMAN
MINT-7252174   MYLK_HUMAN
MINT-7252186   PEBP1_HUMAN
MINT-7252234   CAF1A_HUMAN
MINT-7252258   DTBP1_HUMAN
MINT-7252270   NELFB_HUMAN
MINT-7252282   AKAP6_HUMAN
MINT-7252294   FANCA_HUMAN
MINT-7252318   GHR_HUMAN
MINT-7252330   M4K1_HUMAN
MINT-7252342   RPGF1_HUMAN
MINT-7296136   SRC_HUMAN
MINT-7306624   LCP2_HUMAN
GO-Terms:
[show]
Conservation:

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Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 368 RDASTKMHGDYTLTLRKGGNN INSR 8385099
LTP
0.95
- SH2
0.45
2IUG 6.99%
Y 580 LIQLRKTRDQYLMWLTQKGVR INSR 8385099
LTP
1.00
- -
0.29
2RD0 55.02%
Y 607 WLGNENTEDQYSLVEDDEDLP INSR 8385099
LTP
1.00
- -
0.55
--

Substrate: Tyrosine-protein phosphatase, non-receptor type 1 (Protein tyrosine phosphatase 1B)
Seq-ID: P18031 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-51115   PPIP1_HUMAN
MINT-73489   CADH2_HUMAN
MINT-6744190   CSK21_HUMAN
MINT-6761890   GSK3B_HUMAN
MINT-6761899   ESR1_HUMAN
MINT-6762163   IKBA_HUMAN
MINT-6762380   PGFRB_HUMAN
MINT-6762549   PAXI_MOUSE
MINT-6762573   FAK1_MOUSE
MINT-6762866   IRS1_RAT
MINT-6763504   BCAR1_MOUSE
MINT-6763556   INSR_RAT
MINT-6764602   JAK2_HUMAN
MINT-6764613   STAT3_HUMAN
MINT-6764665   TRPV6_HUMAN
MINT-6764866   CAV1_HUMAN
MINT-6765163   PIAS1_HUMAN
MINT-6765185   SUMO1_HUMAN
MINT-6765318   CTND1_MOUSE
MINT-6765333   LPP_MOUSE
MINT-6765355   SRC8_MOUSE
MINT-6765370   ZO1_MOUSE
MINT-6765383   PLCG1_MOUSE
MINT-6765422   DOK1_MOUSE
MINT-6765439   EGFR_MOUSE
MINT-6765460   PGFRB_MOUSE
MINT-6787689   MET_HUMAN
MINT-6787710   ABL1_HUMAN
MINT-6793324   B3AT_HUMAN
MINT-6793358   EGFR_HUMAN
MINT-6793387   CAN1_HUMAN
MINT-6793394   CAN2_HUMAN
MINT-6793439   IRS1_MOUSE
MINT-6793452   INSR_MOUSE
MINT-6793484   BCAR1_HUMAN
MINT-6793722   AKT1_MOUSE
MINT-6793745   IRS1_HUMAN
MINT-6793782   TYK2_HUMAN
MINT-6793941   NTRK1_HUMAN
MINT-6793957   NTRK3_HUMAN
MINT-6793973   LTK_HUMAN
MINT-6793989   STA5A_HUMAN
MINT-6794005   STA5B_HUMAN
MINT-6794135   LAT_HUMAN
MINT-6794748   EPOR_HUMAN
MINT-6794792   GRB2_HUMAN
MINT-6794817   ITB3_HUMAN
MINT-6794878   ACTS_HUMAN
MINT-6794892   FAK1_HUMAN
MINT-6794946   INSR_HUMAN
MINT-6794972   KPCG_HUMAN
MINT-6795050   JAK2_MOUSE
MINT-6795199   SRC8_HUMAN
MINT-6795447   SRC_HUMAN
MINT-6796717   PLD2_HUMAN
MINT-6797067   CLK2_HUMAN
MINT-6797829   GHR_HUMAN
MINT-6799814   ROS_HUMAN
MINT-6800783   IGF1R_HUMAN
MINT-7972220   DLG4_RAT
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
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Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 152 LTLISEDIKSYYTVRQLELEN INSR 11106648
LTP
0.95
- PTPc_DSPc
0.14
2CM2 56.33%
Y 153 TLISEDIKSYYTVRQLELENL INSR 11106648
LTP
1.00
- PTPc_DSPc
0.17
2CM2 13.10%

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