List of substrates found:


Substrate: MAP2K1 (Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.1.-) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1))
Seq-ID: Q02750 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16002   KSR1_MOUSE
MINT-3391583   M3K1_HUMAN
MINT-4300484   MK01_HUMAN
MINT-7014370   RAF1_HUMAN
MINT-7014390   MK03_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
MAP kinase kinase activity,
ATP binding,
protein tyrosine kinase activity		 cytosol senescence,
negative regulation of cell proliferation,
cell cycle arrest,
chemotaxis,
Ras protein signal transduction
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 23 PAPDGSAVNGTSSAETNLEAL MAP2K_group 7873542
LTP
0.17
 - COIL
0.69
 --
S 24 APDGSAVNGTSSAETNLEALQ MAP2K_group 7873542
LTP
0.44
 - COIL
0.65
 --
S 25 PDGSAVNGTSSAETNLEALQK MAP2K_group 7873542
LTP
0.02
 - COIL
0.63
 --
S 218 DFGVSGQLIDSMANSFVGTRS MAP2K_group 7873542
LTP
1.00
 - S_TKc
0.20
 3EQC 29.51%
S 298 PRPRTPGRPLSSYGMDSRPPM MAP2K_group 7873542
LTP
0.74
 - S_TKc
0.69
 --

Substrate: Mitogen-activated protein kinase 1 (S/T/Y kinase)
Seq-ID: P28482 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-51440   BCL2_HUMAN
MINT-60779   LCK_HUMAN
MINT-65987   YBOX1_HUMAN
MINT-65988   DBPA_HUMAN
MINT-2835582   IEX1_HUMAN
MINT-4300420   PEA15_HUMAN
MINT-4300484   MP2K1_HUMAN
MINT-4301855   CIC_DROME
MINT-4329848   CASP8_HUMAN
MINT-6613181   MBP_BOVIN
MINT-7973774   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA binding,
ATP binding		 microtubule cytoskeleton,
cytosol,
nucleoplasm		 transcription,
cell cycle,
chemotaxis,
interspecies interaction between organisms,
synaptic transmission,
Ras protein signal transduction,
induction of apoptosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 185 DPDHDHTGFLTEYVATRWYRA MAP2K_group 11971971
LTP
1.00
 - S_TKc
0.15
 2GPH 73.97%

Substrate: Mitogen-activated protein kinase 10 (Mitogen activated protein kinase 10)
Seq-ID: P53779 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-63869   TF3C1_HUMAN
MINT-7148332   JUN_HUMAN
MINT-7263136   ARRB1_HUMAN
MINT-7263161   ARRB2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
JUN kinase activity,
MAP kinase kinase activity,
ATP binding,
protein binding		 nucleoplasm
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 221 ARTAGTSFMMTPYVVTRYYRA MAP2K_group 15911620
LTP
1.00
 - S_TKc
0.08
 2O0U 45.21%

Substrate: Mitogen-activated protein kinase 14 (Mitogen-activated protein kinase 14)
Seq-ID: Q16539 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-17884   TAB1_HUMAN
MINT-64844   FKBP8_HUMAN
MINT-66629   TISB_HUMAN
MINT-2833254   LIMK1_HUMAN
MINT-2834463   NCOA3_HUMAN
MINT-4300259   MP2K3_HUMAN
MINT-4300277   MP2K6_HUMAN
MINT-4793793   RB_HUMAN
MINT-7557394   ATG9A_HUMAN
MINT-7973662   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
MP kinase activity,
MAP kinase kinase activity,
ATP binding,
protein binding		 cytosol,
nucleoplasm		 protein amino acid phosphorylation,
response to stress,
cellular component movement,
chemotaxis,
cell surface receptor linked signaling pathway,
Ras protein signal transduction,
intracellular protein kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 180 GLARHTDDEMTGYVATRWYRA MAP2K_group 7750576
LTP
1.00
 - S_TKc
0.18
 2GFS 55.48%
Y 182 ARHTDDEMTGYVATRWYRAPE MAP2K_group 15735649
LTP
1.00
 - S_TKc
0.19
 2GFS 62.88%

Substrate: Mitogen-activated protein kinase 3 (S/T/Y kinase)
Seq-ID: P27361 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-17608   KSR1_MOUSE
MINT-56633   GAB2_HUMAN
MINT-4329823   CASP8_HUMAN
MINT-7014390   MP2K1_HUMAN
MINT-7717318   SQSTM_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
ATP binding,
MAP kinase activity		 microtubule cytoskeleton,
cytosol,
nucleoplasm		 protein amino acid phosphorylation,
cell cycle,
interspecies interaction between organisms,
Ras protein signal transduction
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 202 DPEHDHTGFLTEYVATRWYRA MAP2K_group 11971971
LTP
1.00
 - S_TKc
0.15
 2ZOQ 26.71%
Y 204 EHDHTGFLTEYVATRWYRAPE MAP2K_group 11971971
LTP
1.00
 - S_TKc
0.13
 2ZOQ 48.47%

Substrate: Mitogen-activated protein kinase 9 (Mitogen-activated protein kinase 9)
Seq-ID: P45984 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-64910   XPO7_HUMAN
MINT-66639   K1712_HUMAN
MINT-68376   WDR62_HUMAN
MINT-7148323   JUN_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
JUN kinase activity,
ATP binding,
protein binding		 nucleoplasm positive regulation of macrophage derived foam cell differentiation,
positive regulation of gene expression
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 404 NDISSMSTEQTLASDTDSSLD MAP2K_group 11062067
LTP
1.00
 - -
0.72
 - low
S 407 SSMSTEQTLASDTDSSLDAST MAP2K_group 11062067
LTP
0.83
 - -
0.77
 - low

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