Click on substrate name for additional information.


Substrate: MAP3K7 (Mitogen-activated protein kinase kinase kinase 7)
Seq-ID: O43318 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-2842623   TAB1_HUMAN
MINT-2842686   TAB2_HUMAN
MINT-3391633   MP2K7_HUMAN
MINT-4652778   IKKB_HUMAN
MINT-4652797   NEMO_HUMAN
MINT-6177574   MALT1_HUMAN
MINT-6629291   JIP1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
magnesium ion binding,
ATP binding,
MAP kinase kinase kinase activity,
protein binding		 cytosol,
endosome membrane		 positive regulation of I-kappaB kinase/NF-kappaB cascade,
positive regulation of JUN kinase activity,
positive regulation of T cell cytokine production,
activation of NF-kappaB-inducing kinase activity,
I-kappaB phosphorylation,
positive regulation of T cell activation,
transforming growth factor beta receptor signaling pathway,
T cell receptor signaling pathway,
positive regulation of interleukin-2 production
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 184 CDFGTACDIQTHMTNNKGSAA MAP3K7 10838074
LTP
1.00
 - STYKc
0.22
 - low
T 187 GTACDIQTHMTNNKGSAAWMA MAP3K7 10838074
LTP
1.00
 - STYKc
0.26
 - low
S 192 IQTHMTNNKGSAAWMAPEVFE MAP3K7 10838074
LTP
1.00
 - STYKc
0.31
 - low

Substrate: MAP3K7 (Mitogen-activated protein kinase kinase kinase 7)
Seq-ID: Q62073 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
magnesium ion binding,
MAP kinase kinase activity,
ATP binding,
MAP kinase kinase kinase activity,
protein binding		 negative regulation of apoptosis,
angiogenesis,
positive regulation of I-kappaB kinase/NF-kappaB cascade,
MAPKKK cascade,
positive regulation of JUN kinase activity,
I-kappaB phosphorylation,
transforming growth factor beta receptor signaling pathway,
positive regulation of JNK cascade,
neural tube formation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 192 IQTHMTNNKGSAAWMAPEVFE MAP3K7 10702308
LTP
1.00
 - STYKc
0.31
 - medium

Valid HTML 4.01 Transitional