List of substrates found:


Substrate: Arachidonate 5 lipoxygenase (Enzyme: Lipase)
Seq-ID: P09917 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
arachidonate 5-lipoxygenase activity,
iron ion binding,
lipoxygenase activity,
protein binding		 nuclear envelope lumen,
cytosol,
nuclear membrane,
nuclear matrix		 oxidation reduction,
leukotriene biosynthetic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 272 MVECSLERQLSLEQEVQQGNI MAPKAPK2 10779545
LTP
0.64
 - Lipoxygenase
0.18
 - high

Substrate: BAG2 (chaperone regulator activity)
Seq-ID: O95816 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-48271   M3K1_HUMAN
MINT-48367   M3K3_HUMAN
MINT-48636   NFKB1_HUMAN
MINT-48783   M3K14_HUMAN
MINT-49182   TAB2_HUMAN
MINT-49367   TNR1B_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein binding protein folding,
apoptosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 20 ANEGRFCRSSSMADRSSRLLE MAPKAPK2 15271996
LTP
1.00
 - COIL
0.48
 - medium

Substrate: cdc25B (Dual specificity phosphatase)
Seq-ID: P30305 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19329   1433Z_HUMAN
MINT-19330   1433F_HUMAN
MINT-25122   1433B_HUMAN
MINT-51069   1433S_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein tyrosine phosphatase activity,
protein binding		 cytosol,
microtubule organizing center,
nucleoplasm		 positive regulation of cell proliferation,
cell division,
protein amino acid dephosphorylation,
mitosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 323 SKCQRLFRSPSMPCSVIRPIL MAPKAPK2 15629715
LTP
1.00
 MOD_ProDKin_1
 YWHAH 14-3-3 M-inducer_phosp
0.29
 - medium

Substrate: CHOP (Transcription factor)
Seq-ID: P35639 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
sequence-specific DNA binding,
sequence-specific DNA binding transcription factor activity,
protein binding		 nucleus cell cycle arrest,
negative regulation of canonical Wnt receptor signaling pathway,
ER overload response,
regulation of transcription, DNA-dependent,
endoplasmic reticulum unfolded protein response
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 78 GPTEVTRTSQSPRSPDSSQSS MAPKAPK2 8650547
LTP
1.00
 MOD_ProDKin_1
 - -
0.93
 - medium
S 81 EVTRTSQSPRSPDSSQSSMAQ MAPKAPK2 8650547
LTP
1.00
 MOD_ProDKin_1
 - -
0.92
 - medium

Substrate: CREB (cAMP response element binding protein (CREB).)
Seq-ID: P16220 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-16217   BRCA1_HUMAN
MINT-56642   SGK1_HUMAN
MINT-63231   RECQ5_HUMAN
MINT-63483   VIME_HUMAN
MINT-63485   CHD3_HUMAN
MINT-4979977   CBP_HUMAN
MINT-5209851   EP300_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein dimerization activity,
transcription cofactor activity		 protein amino acid phosphorylation,
signal transduction,
interspecies interaction between organisms,
response to organic substance
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 133 KRREILSRRPSYRKILNDLSS MAPKAPK2 8887554
LTP
1.00
 - pKID
0.54
 - low

Substrate: eEF-2 kinase (Elongation factor 2 kinase)
Seq-ID: O00418 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-15495   KS6B2_HUMAN
MINT-17060   KS6A1_HUMAN
MINT-6549466   CDC2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
translation factor activity, nucleic acid binding,
calcium ion binding,
ATP binding,
elongation factor-2 kinase activity,
calmodulin binding		 cytosol protein amino acid phosphorylation,
translational elongation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 377 GSRPPLLRPLSENSGDENMSD MAPKAPK2 12171600
LTP
1.00
 - -
0.79
 - medium

Substrate: Heterogeneous nuclear ribonucleoprotein A0 (This protein is a component of ribonucleosomes)
Seq-ID: ENSMUSP00000007980 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
nucleotide binding,
nucleic acid binding
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 84 GNTVELKRAVSREDSARPGAH MAPKAPK2 12456657
LTP
1.00
 - -
0.54
 - medium

Substrate: HSF 1 (Transcription factor)
Seq-ID: Q00613 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-1785958   STUB1_HUMAN
MINT-6743391   STRAP_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
sequence-specific DNA binding transcription factor activity,
protein binding		 cytoplasm transcription,
regulation of transcription, DNA-dependent
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 121 LLENIKRKVTSVSTLKSEDIK MAPKAPK2 16278218
LTP
0.22
 - HSF_DNA-bind
0.31
 - high

Substrate: HSP27 (heat shock 27 kD protein (HSP 27) (from PhosphoBase))
Seq-ID: P04792 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14024   IF4G1_HUMAN
MINT-16434   CRYAA_HUMAN
MINT-16469   CRBB2_HUMAN
MINT-17168   CRYAB_HUMAN
MINT-65132   P53_HUMAN
MINT-65135   CA103_HUMAN
MINT-3305331   1433Z_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
identical protein binding spindle,
cell surface,
nucleus		 response to unfolded protein,
anti-apoptosis,
cellular component movement,
response to heat,
regulation of translational initiation,
cell death,
response to virus
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 15 RVPFSLLRGPSWDPFRDWYPH MAPKAPK2 1332886
LTP
1.00
 - -
0.14
 - medium
S 15 RVPFSLLRGPSWDPFRDWYPH MAPKAPK2 10383393
LTP
1.00
 - -
0.14
 - medium
S 78 VAAPAYSRALSRQLSSGVSEI MAPKAPK2 1332886
LTP
0.26
 - -
0.40
 - medium
S 78 VAAPAYSRALSRQLSSGVSEI MAPKAPK2 10383393
LTP
0.26
 - -
0.40
 - medium
S 82 AYSRALSRQLSSGVSEIRHTA MAPKAPK2 1332886
LTP
0.30
 - -
0.42
 - medium
S 82 AYSRALSRQLSSGVSEIRHTA MAPKAPK2 1332886
LTP
0.30
 - -
0.42
 - medium

Substrate: Lymphocyte specific protein (Calcium binding protein)
Seq-ID: P33241 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
actin binding,
signal transducer activity		 plasma membrane,
actin cytoskeleton		 cellular component movement,
cellular defense response
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 204 PTTKLIDRTESLNRSIEKSNS MAPKAPK2 8995217
LTP
1.00
 - -
0.67
 - medium
S 252 GRTPKLARQASIELPSMAVAS MAPKAPK2 8995217
LTP
1.00
 - -
0.63
 - medium

Substrate: MAP kinase-activated protein kinase 2 (MAP kinase-activated protein kinase 2 (EC 2.7.1.-) (from PhosphoBase))
Seq-ID: P49137 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
MINT-2833388   LIMK1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
ATP binding,
signal transducer activity,
protein binding		 cytosol,
nucleus		 protein amino acid phosphorylation,
MAPKKK cascade,
Ras protein signal transduction
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 338 STKVPQTPLHTSRVLKEDKER MAPKAPK2 8846784
LTP
0.87
 - -
0.55
 2OZA 0.00%

Substrate: SRF (Serum response factor)
Seq-ID: P11831 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-15523   MYOD1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein homodimerization activity,
specific RNA polymerase II transcription factor activity,
transcription factor binding,
sequence-specific DNA binding transcription factor activity,
serum response element binding		 cytoplasm,
nucleus		 senescence,
transcription,
positive regulation of cell differentiation,
neuron development,
regulation of smooth muscle cell differentiation,
response to hormone stimulus,
response to toxin,
positive regulation of transcription via serum response element binding,
response to cytokine stimulus,
heart looping,
positive regulation of smooth muscle contraction,
cell migration involved in sprouting angiogenesis,
muscle cell homeostasis,
trophectodermal cell differentiation,
angiogenesis involved in wound healing,
positive regulation of transcription initiation from RNA polymerase II promoter
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 85 LYSGSEGDSESGEEEELGAER MAPKAPK2 10318869
LTP
0.31
 - -
0.79
 --

Substrate: Tristetraproline (tristetraproline (TTP) (TIS11A) (TIS11) (ZFP-36) (from PhosphoBase))
Seq-ID: P22893 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA binding,
AU-rich element binding,
mRNA binding,
zinc ion binding		 cytosol,
nucleus		 negative regulation of myeloid cell differentiation,
negative regulation of inflammatory response,
nuclear-transcribed mRNA poly(A) tail shortening,
regulation of mRNA stability,
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening,
RNA destabilization,
intracellular protein kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 52 VTSRLTGRSTSLVEGRSCGWV MAPKAPK2 14688255
LTP
1.00
 YWHAB 14-3-3 -
0.45
 - low
S 80 PLAPRPGPELSPSPTSPTATP MAPKAPK2 14688255
LTP
0.62
 MOD_ProDKin_1
 - -
0.86
 - low
S 82 APRPGPELSPSPTSPTATPTT MAPKAPK2 14688255
LTP
0.62
 MOD_ProDKin_1
 - -
0.89
 - low
S 85 PGPELSPSPTSPTATPTTSSR MAPKAPK2 14688255
LTP
0.51
 MOD_ProDKin_1
 - -
0.87
 - low
S 178 GQPHVLRQSISFSGLPSGRRS MAPKAPK2 14688255
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAG 14-3-3;
YWHAZ 14-3-3		 -
0.65
 - low
T 250 ACCPSCRRSTTPSTIWGPLGG MAPKAPK2 14688255
LTP
0.33
 MOD_ProDKin_1
 - -
0.43
 - low
S 316 PRRLPIFNRISVSE        MAPKAPK2 14688255
LTP
1.00
 - -
0.48
 - low

Substrate: Tuberin (GTPase activating protein)
Seq-ID: P49815 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14051   1433T_HUMAN
MINT-16238   TSC1_HUMAN
MINT-16580   1433F_HUMAN
MINT-17162   1433B_HUMAN
MINT-17710   1433S_HUMAN
MINT-3317863   1433Z_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein homodimerization activity,
GTPase activator activity		 TSC1-TSC2 complex,
Golgi apparatus,
nucleus,
perinuclear region of cytoplasm		 neural tube closure,
protein import into nucleus,
regulation of insulin receptor signaling pathway,
positive regulation of GTPase activity,
insulin-like growth factor receptor signaling pathway,
heart development,
negative regulation of phosphoinositide 3-kinase cascade,
superior temporal gyrus development,
positive chemotaxis,
protein kinase B signaling cascade,
regulation of small GTPase mediated signal transduction,
regulation of endocytosis,
endocytosis,
negative regulation of protein kinase B signaling cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 1254 HRDTALYKSLSVPAASTAKPP MAPKAPK2 12582162
LTP
0.11
 - -
0.56
 - medium

Substrate: Tyr-3-hydroxylase (tyrosine 3-monooxygenase (tyrosine 3-hydroxylase) (TH) (from PhosphoBase))
Seq-ID: P07101 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
tyrosine 3-monooxygenase activity,
protein binding		 smooth endoplasmic reticulum,
perikaryon,
internal side of plasma membrane,
cytosol,
melanosome membrane,
nucleus		 synaptic transmission, dopaminergic,
embryonic camera-type eye morphogenesis,
neurotransmitter biosynthetic process,
oxidation reduction,
response to hypoxia,
heart morphogenesis,
learning,
eye photoreceptor cell development,
regulation of heart contraction,
visual perception,
norepinephrine biosynthetic process,
dopamine biosynthetic process from tyrosine,
locomotory behavior,
memory,
epinephrine biosynthetic process,
pigmentation,
response to ethanol
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 19 PQAKGFRRAVSELDAKQAEAI MAPKAPK2 7901013
LTP
1.00
 - -
0.58
 - low
S 40 MVRGQGAPGPSLTGSPWPGTA MAPKAPK2 7901013
LTP
 - - -
0.78
 - low

Substrate: Vimentin (vimentin (from PhosphoBase))
Seq-ID: P08670 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-48218   NEMO_HUMAN
MINT-48335   M3K1_HUMAN
MINT-48490   M3K3_HUMAN
MINT-48555   NFKB1_HUMAN
MINT-49072   RIPK2_HUMAN
MINT-49446   TNR1B_HUMAN
MINT-51249   SMAD3_HUMAN
MINT-63478   FABP4_HUMAN
MINT-63483   CREB1_HUMAN
MINT-63519   SYN1_HUMAN
MINT-64054   RAD51_HUMAN
MINT-64131   TIF1B_HUMAN
MINT-64137   NFAC2_HUMAN
MINT-64185   CASP8_HUMAN
MINT-64286   STX1A_HUMAN
MINT-64820   Q86V38_HUMAN
MINT-64930   SIRT6_HUMAN
MINT-64945   CA103_HUMAN
MINT-64988   PAIRB_HUMAN
MINT-65109   FUBP1_HUMAN
MINT-65490   TARA_HUMAN
MINT-65741   PUF60_HUMAN
MINT-65855   SRRT_HUMAN
MINT-65878   NS1BP_HUMAN
MINT-66105   MYST2_HUMAN
MINT-66208   ABLM1_HUMAN
MINT-66844   K1C20_HUMAN
MINT-66894   GFAP_HUMAN
MINT-67503   PDLI1_HUMAN
MINT-67553   PSA1_HUMAN
MINT-67944   GOPC_HUMAN
MINT-2515544   SYUA_HUMAN
MINT-2791056   RD23A_HUMAN
MINT-2791422   RD23B_HUMAN
MINT-2985160   ZO1_HUMAN
MINT-3297793   1433Z_HUMAN
MINT-3979536   CHD3_HUMAN
MINT-3979774   ZHX1_HUMAN
MINT-3980301   SETB1_HUMAN
MINT-3980318   NFL_HUMAN
MINT-3980438   ING5_HUMAN
MINT-3980472   PPHLN_HUMAN
MINT-3980489   UT14A_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein C-terminus binding,
structural constituent of cytoskeleton		 intermediate filament,
cytosol		 cellular component movement,
interspecies interaction between organisms
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 39 SYVTTSTRTYSLGSALRPSTS MAPKAPK2 12761892
LTP
0.71
 - Filament_head
0.49
 --
S 51 GSALRPSTSRSLYASSPGGVY MAPKAPK2 12761892
LTP
0.61
 - Filament_head
0.47
 --
S 56 PSTSRSLYASSPGGVYATRSS MAPKAPK2 12761892
LTP
0.61
 MOD_ProDKin_1
 - Filament_head
0.48
 --
S 83 SVPGVRLLQDSVDFSLADAIN MAPKAPK2 12761892
LTP
0.69
 - Filament_head
0.30
 --

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