Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

Click on substrate name for additional information.

Substrate: c-met (Receptor tyrosine kinase for hepatocyte growth factor.)

Seq-ID: P08581 [Homo sapiens]

Download: fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):
[show]

MINT-18299   RANB9_HUMAN
MINT-58374   GAB1_MOUSE
MINT-58404   GAB1_HUMAN
MINT-6539587   CBL_HUMAN
MINT-6787689   PTN1_HUMAN
MINT-6798640   PTN11_HUMAN

GO-Terms:
[show]

Molecular Function Cellular Component Biological Process

hepatocyte growth factor receptor activity,
ATP binding,
protein binding integral to plasma membrane,
basal plasma membrane protein amino acid phosphorylation,
multicellular organismal development,
cell proliferation

Conservation:

Click on table headers for sorting

Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.

Y 1230 VADFGLARDMYDKEYYSVHNK Met 12475979
LTP

1.00
- TyrKc
0.11
3F66 34.06%

Y 1234 GLARDMYDKEYYSVHNKTGAK Met 1247597
LTP

1.00
- TyrKc
0.18
3F66 31.88%

Y 1234 GLARDMYDKEYYSVHNKTGAK Met 8302603
LTP

1.00
- TyrKc
0.18
3F66 31.88%

Y 1234 GLARDMYDKEYYSVHNKTGAK Met 7961992
LTP

1.00
- TyrKc
0.18
3F66 31.88%

Y 1235 LARDMYDKEYYSVHNKTGAKL Met 8302603
LTP

1.00
- TyrKc
0.18
3F66 10.48%

Y 1349 AIFSTFIGEHYVHVNATYVNV Met 12475979
LTP

1.00
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2 -
0.03
3F66 100.00%

Y 1349 AIFSTFIGEHYVHVNATYVNV Met 7731718
LTP

1.00
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2 -
0.03
3F66 100.00%

Y 1349 AIFSTFIGEHYVHVNATYVNV Met 7687741
LTP

1.00
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2 -
0.03
3F66 100.00%

Y 1356 GEHYVHVNATYVNVKCVAPYP Met 7731718
LTP

1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2 -
0.06
1R0P 15.72%

Y 1356 GEHYVHVNATYVNVKCVAPYP Met 7961992
LTP

1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2 -
0.06
1R0P 15.72%

Y 1356 GEHYVHVNATYVNVKCVAPYP Met 7687741
LTP

1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2 -
0.06
1R0P 15.72%

Substrate: c-met (Receptor tyrosine kinase for hepatocyte growth factor.)

Seq-ID: P16056 [Mus musculus]

Download: fasta csv

Interaction Network(s): -

External Source(s):

MINT Interaction(s):
MINT-58371   GAB1_MOUSE

GO-Terms:
[show]

Molecular Function Cellular Component Biological Process

hepatocyte growth factor receptor activity,
ATP binding,
protein binding membrane fraction,
integral to membrane brain development,
muscle cell migration,
myotube differentiation,
regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling,
placenta development,
adult behavior,
myoblast proliferation,
protein amino acid autophosphorylation,
activation of MAPK activity,
skeletal muscle tissue development,
liver development

Conservation:

Click on table headers for sorting

Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.

Y 1228 VADFGLARDMYDKEYYSVHNK Met 8302603
LTP

1.00
- TyrKc
0.11
3F66 34.06%

Y 1232 GLARDMYDKEYYSVHNKTGAK Met 8302603
LTP

1.00
- TyrKc
0.17
3F66 31.88%

Y 1233 LARDMYDKEYYSVHNKTGAKL Met 8302603
LTP

1.00
- TyrKc
0.17
3F66 10.48%

Y 1233 LARDMYDKEYYSVHNKTGAKL Met 1655790
LTP

1.00
- TyrKc
0.17
3F66 10.48%

Substrate: Gab1 (Multisubstrate docking protein downstream in the signaling pathways of different RTK.)

Seq-ID: Q13480 [Homo sapiens]

Download: fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):
[show]

MINT-58395   GRB2_HUMAN
MINT-58403   GRAP2_HUMAN
MINT-58404   MET_HUMAN
MINT-68564   BMX_HUMAN
MINT-1893011   P85A_HUMAN
MINT-6169406   PTN11_HUMAN
MINT-6169502   PAXI_HUMAN
MINT-7971128   DLG4_RAT

GO-Terms:
[show]

Molecular Function Cellular Component Biological Process

SH3/SH2 adaptor activity cytosol epidermal growth factor receptor signaling pathway,
insulin receptor signaling pathway,
cell proliferation

Conservation:

Click on table headers for sorting

Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.

Y 285 PSSTEADGELYVFNTPSGTSS Met 10734310
LTP

0.93
- -
0.71
- low

Y 307 ETQMRHVSISYDIPPTPGNTY Met 10734310
LTP

0.12
CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2 -
0.70
- low

Y 373 PRTASDTDSSYCIPTAGMSPS Met 10734310
LTP

0.08
CRKL SH2;
CRK SH2;
PLCG1 SH2 -
0.66
- low

Y 406 LRKDASSQDCYDIPRAFPSDR Met 10734310
LTP

1.00
CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2;
SHC_group SH2 -
0.61
- low

Y 447 SVSSEELDENYVPMNPNSPPR Met 10734310
LTP

1.00
PIK3R1 SH2;
PIK3R2 SH2;
PTPN11 SH2 -
0.83
- low

Y 472 SFTEPIQEANYVPMTPGTFDF Met 10734310
LTP

1.00
PIK3R1 SH2;
PIK3R2 SH2 -
0.54
- low

Y 589 SSDSHDSEENYVPMNPNLSSE Met 10734310
LTP

1.00
PIK3R1 SH2;
PTPN11 SH2 -
0.89
- low

Y 627 IKPKGDKQVEYLDLDLDSGKS Met 10734310
LTP

1.00
PTPN11 SH2 -
0.72
- low

Y 659 GSSVADERVDYVVVDQQKTLA Met 10734310
LTP

1.00
PTPN11 SH2 -
0.61
- low

Substrate: Gab1 (Multisubstrate docking protein downstream in the signaling pathways of different RTK.)

Seq-ID: Q9QYY0 [Mus musculus]

Download: fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):
[show]

MINT-58371   MET_MOUSE
MINT-58374   MET_HUMAN
MINT-58378   PLCG1_MOUSE
MINT-58379   SHC1_MOUSE
MINT-58385   SHIP2_HUMAN
MINT-58390   CRKL_HUMAN

GO-Terms:
[show]

Molecular Function Cellular Component Biological Process

signal transducer activity,
protein binding cytoplasm epidermis development,
interleukin-6-mediated signaling pathway,
positive regulation of MAPKKK cascade,
regulation of cell migration,
response to oxidative stress,
activation of JUN kinase activity,
epidermal growth factor receptor signaling pathway,
heart development,
labyrinthine layer development,
platelet-derived growth factor receptor signaling pathway

Conservation:

Click on table headers for sorting

Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.

Y 285 PSSTEADGELYTFNTPSGTAG Met 10734310
LTP

0.93
- -
0.77
- medium

Y 307 ETQMRHVSISYDIPPTPGNTY Met 10734310
LTP

0.12
- -
0.71
- medium

Y 373 PRTASDTDSSYCIPPPAGMTP Met 10734310
LTP

0.08
- -
0.75
- medium

Y 407 LRKDASSQDCYDIPRTFPSDR Met 10734310
LTP

1.00
- -
0.66
- medium

Y 448 GVSGEELDENYVPMNPNSPPR Met 10734310
LTP

1.00
- -
0.87
- medium

Y 473 SFTEPIQEPNYVPMTPGTFDF Met 10734310
LTP

1.00
- -
0.61
- medium

Y 590 SSDSHDSEENYVPMNPNLSGE Met 10734310
LTP

1.00
- -
0.90
- medium

Y 628 NKPKGDKQVEYLDLDLDSGKS Met 10734310
LTP

1.00
- -
0.78
- medium

Y 660 GSSMADERVDYVVVDQQKTLA Met 10734310
LTP

1.00
- -
0.68
- medium

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1230	VADFGLARDMYDKEYYSVHNK	Met	12475979	LTP	1.00	-	TyrKc	0.11	3F66	34.06%
Y	1234	GLARDMYDKEYYSVHNKTGAK	Met	1247597	LTP	1.00	-	TyrKc	0.18	3F66	31.88%
Y	1234	GLARDMYDKEYYSVHNKTGAK	Met	8302603	LTP	1.00	-	TyrKc	0.18	3F66	31.88%
Y	1234	GLARDMYDKEYYSVHNKTGAK	Met	7961992	LTP	1.00	-	TyrKc	0.18	3F66	31.88%
Y	1235	LARDMYDKEYYSVHNKTGAKL	Met	8302603	LTP	1.00	-	TyrKc	0.18	3F66	10.48%
Y	1349	AIFSTFIGEHYVHVNATYVNV	Met	12475979	LTP	1.00	GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.03	3F66	100.00%
Y	1349	AIFSTFIGEHYVHVNATYVNV	Met	7731718	LTP	1.00	GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.03	3F66	100.00%
Y	1349	AIFSTFIGEHYVHVNATYVNV	Met	7687741	LTP	1.00	GRB2 SH2; Lck SH2; PIK3R1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.03	3F66	100.00%
Y	1356	GEHYVHVNATYVNVKCVAPYP	Met	7731718	LTP	1.00	GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	Met	7961992	LTP	1.00	GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%
Y	1356	GEHYVHVNATYVNVKCVAPYP	Met	7687741	LTP	1.00	GRB2 SH2; INPP5D SH2; INPPL1 SH2; PIK3R1 SH2; PLCG1 SH2; PLCG_group SH2; SHC_group SH2; Src SH2	-	0.06	1R0P	15.72%

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1228	VADFGLARDMYDKEYYSVHNK	Met	8302603	LTP	1.00	-	TyrKc	0.11	3F66	34.06%
Y	1232	GLARDMYDKEYYSVHNKTGAK	Met	8302603	LTP	1.00	-	TyrKc	0.17	3F66	31.88%
Y	1233	LARDMYDKEYYSVHNKTGAKL	Met	8302603	LTP	1.00	-	TyrKc	0.17	3F66	10.48%
Y	1233	LARDMYDKEYYSVHNKTGAKL	Met	1655790	LTP	1.00	-	TyrKc	0.17	3F66	10.48%

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	285	PSSTEADGELYVFNTPSGTSS	Met	10734310	LTP	0.93	-	-	0.71	-	low
Y	307	ETQMRHVSISYDIPPTPGNTY	Met	10734310	LTP	0.12	CRKL SH2; CRK SH2; NCK SH2; PLCG1 SH2	-	0.70	-	low
Y	373	PRTASDTDSSYCIPTAGMSPS	Met	10734310	LTP	0.08	CRKL SH2; CRK SH2; PLCG1 SH2	-	0.66	-	low
Y	406	LRKDASSQDCYDIPRAFPSDR	Met	10734310	LTP	1.00	CRKL SH2; CRK SH2; NCK SH2; PLCG1 SH2; SHC_group SH2	-	0.61	-	low
Y	447	SVSSEELDENYVPMNPNSPPR	Met	10734310	LTP	1.00	PIK3R1 SH2; PIK3R2 SH2; PTPN11 SH2	-	0.83	-	low
Y	472	SFTEPIQEANYVPMTPGTFDF	Met	10734310	LTP	1.00	PIK3R1 SH2; PIK3R2 SH2	-	0.54	-	low
Y	589	SSDSHDSEENYVPMNPNLSSE	Met	10734310	LTP	1.00	PIK3R1 SH2; PTPN11 SH2	-	0.89	-	low
Y	627	IKPKGDKQVEYLDLDLDSGKS	Met	10734310	LTP	1.00	PTPN11 SH2	-	0.72	-	low
Y	659	GSSVADERVDYVVVDQQKTLA	Met	10734310	LTP	1.00	PTPN11 SH2	-	0.61	-	low

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	285	PSSTEADGELYTFNTPSGTAG	Met	10734310	LTP	0.93	-	-	0.77	-	medium
Y	307	ETQMRHVSISYDIPPTPGNTY	Met	10734310	LTP	0.12	-	-	0.71	-	medium
Y	373	PRTASDTDSSYCIPPPAGMTP	Met	10734310	LTP	0.08	-	-	0.75	-	medium
Y	407	LRKDASSQDCYDIPRTFPSDR	Met	10734310	LTP	1.00	-	-	0.66	-	medium
Y	448	GVSGEELDENYVPMNPNSPPR	Met	10734310	LTP	1.00	-	-	0.87	-	medium
Y	473	SFTEPIQEPNYVPMTPGTFDF	Met	10734310	LTP	1.00	-	-	0.61	-	medium
Y	590	SSDSHDSEENYVPMNPNLSGE	Met	10734310	LTP	1.00	-	-	0.90	-	medium
Y	628	NKPKGDKQVEYLDLDLDSGKS	Met	10734310	LTP	1.00	-	-	0.78	-	medium
Y	660	GSSMADERVDYVVVDQQKTLA	Met	10734310	LTP	1.00	-	-	0.68	-	medium