Click on substrate name for additional information.


Substrate: c-met (Receptor tyrosine kinase for hepatocyte growth factor.)
Seq-ID: P08581 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1230 VADFGLARDMYDKEYYSVHNK Met 12475979
LTP
1.00
- TyrKc
0.11
3F66 34.06%
Y 1234 GLARDMYDKEYYSVHNKTGAK Met 1247597
LTP
1.00
- TyrKc
0.18
3F66 31.88%
Y 1234 GLARDMYDKEYYSVHNKTGAK Met 8302603
LTP
1.00
- TyrKc
0.18
3F66 31.88%
Y 1234 GLARDMYDKEYYSVHNKTGAK Met 7961992
LTP
1.00
- TyrKc
0.18
3F66 31.88%
Y 1235 LARDMYDKEYYSVHNKTGAKL Met 8302603
LTP
1.00
- TyrKc
0.18
3F66 10.48%
Y 1349 AIFSTFIGEHYVHVNATYVNV Met 12475979
LTP
1.00
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.03
3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV Met 7731718
LTP
1.00
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.03
3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV Met 7687741
LTP
1.00
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.03
3F66 100.00%
Y 1356 GEHYVHVNATYVNVKCVAPYP Met 7731718
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP Met 7961992
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP Met 7687741
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%

Substrate: c-met (Receptor tyrosine kinase for hepatocyte growth factor.)
Seq-ID: P16056 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1228 VADFGLARDMYDKEYYSVHNK Met 8302603
LTP
1.00
- TyrKc
0.11
3F66 34.06%
Y 1232 GLARDMYDKEYYSVHNKTGAK Met 8302603
LTP
1.00
- TyrKc
0.17
3F66 31.88%
Y 1233 LARDMYDKEYYSVHNKTGAKL Met 8302603
LTP
1.00
- TyrKc
0.17
3F66 10.48%
Y 1233 LARDMYDKEYYSVHNKTGAKL Met 1655790
LTP
1.00
- TyrKc
0.17
3F66 10.48%

Substrate: Gab1 (Multisubstrate docking protein downstream in the signaling pathways of different RTK.)
Seq-ID: Q13480 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 285 PSSTEADGELYVFNTPSGTSS Met 10734310
LTP
0.93
- -
0.71
- low
Y 307 ETQMRHVSISYDIPPTPGNTY Met 10734310
LTP
0.12
CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2
-
0.70
- low
Y 373 PRTASDTDSSYCIPTAGMSPS Met 10734310
LTP
0.08
CRKL SH2;
CRK SH2;
PLCG1 SH2
-
0.66
- low
Y 406 LRKDASSQDCYDIPRAFPSDR Met 10734310
LTP
1.00
CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2;
SHC_group SH2
-
0.61
- low
Y 447 SVSSEELDENYVPMNPNSPPR Met 10734310
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2;
PTPN11 SH2
-
0.83
- low
Y 472 SFTEPIQEANYVPMTPGTFDF Met 10734310
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2
-
0.54
- low
Y 589 SSDSHDSEENYVPMNPNLSSE Met 10734310
LTP
1.00
PIK3R1 SH2;
PTPN11 SH2
-
0.89
- low
Y 627 IKPKGDKQVEYLDLDLDSGKS Met 10734310
LTP
1.00
PTPN11 SH2 -
0.72
- low
Y 659 GSSVADERVDYVVVDQQKTLA Met 10734310
LTP
1.00
PTPN11 SH2 -
0.61
- low

Substrate: Gab1 (Multisubstrate docking protein downstream in the signaling pathways of different RTK.)
Seq-ID: Q9QYY0 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 285 PSSTEADGELYTFNTPSGTAG Met 10734310
LTP
0.93
- -
0.77
- medium
Y 307 ETQMRHVSISYDIPPTPGNTY Met 10734310
LTP
0.12
- -
0.71
- medium
Y 373 PRTASDTDSSYCIPPPAGMTP Met 10734310
LTP
0.08
- -
0.75
- medium
Y 407 LRKDASSQDCYDIPRTFPSDR Met 10734310
LTP
1.00
- -
0.66
- medium
Y 448 GVSGEELDENYVPMNPNSPPR Met 10734310
LTP
1.00
- -
0.87
- medium
Y 473 SFTEPIQEPNYVPMTPGTFDF Met 10734310
LTP
1.00
- -
0.61
- medium
Y 590 SSDSHDSEENYVPMNPNLSGE Met 10734310
LTP
1.00
- -
0.90
- medium
Y 628 NKPKGDKQVEYLDLDLDSGKS Met 10734310
LTP
1.00
- -
0.78
- medium
Y 660 GSSMADERVDYVVVDQQKTLA Met 10734310
LTP
1.00
- -
0.68
- medium


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