Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

Substrate:

40S ribosomal protein S6 (40S ribosomal protein S6 (phosphoprotein NP33) (from PhosphoBase))

Seq-ID:

P62753 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-48303   M3K1_HUMAN
MINT-48824   M3K14_HUMAN
MINT-72675   HS90B_HUMAN
MINT-2833465   KS6A2_HUMAN
MINT-2833483   KS6B2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
structural constituent of ribosome, protein binding	nucleolus, cytosolic small ribosomal subunit	TOR signaling cascade, ribosomal small subunit biogenesis, glucose homeostasis, rRNA processing, positive regulation of apoptosis, translational elongation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	235	QEQIAKRRRLSSLRASTSKSE	RSK_group	17360704	LTP	0.59		-	COIL	0.73	-	medium
S	236	EQIAKRRRLSSLRASTSKSES	RSK_group	17360704	LTP	0.42		-	COIL	0.74	-	medium

Substrate:

BAD (Bcl2-antagonist of cell death (BAD) (Bcl-2 binding component 6) (Bcl- XL/Bcl-2 associated death promoter) (Bcl-2-like 8 protein))

Seq-ID:

Q61337 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	cytosol, mitochondrial outer membrane	induction of apoptosis by extracellular signals, glucose homeostasis, cytokine-mediated signaling pathway, apoptosis, positive regulation of B cell differentiation, positive regulation of T cell differentiation, glucose catabolic process, cell proliferation, regulation of caspase activity

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	112	GAMETRSRHSSYPAGTEEDEG	RSK_group	10880354	LTP	1.00	MOD_PKB_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Bcl-2_BAD	0.88	-	medium
S	112	GAMETRSRHSSYPAGTEEDEG	RSK_group	16103085	LTP	1.00	MOD_PKB_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Bcl-2_BAD	0.88	-	medium
S	155	QRYGRELRRMSDEFEGSFKGL	RSK_group	10837486	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Bcl-2_BAD	0.60	-	medium
S	155	QRYGRELRRMSDEFEGSFKGL	RSK_group	10880354	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Bcl-2_BAD	0.60	-	medium

Substrate:

BAD (Bcl2-antagonist of cell death (BAD) (Bcl-2 binding component 6) (Bcl- XL/Bcl-2 associated death promoter) (Bcl-2-like 8 protein))

Seq-ID:

Q92934 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14699   B2CL1_HUMAN
MINT-66103   1433S_HUMAN
MINT-7034091   B2L11_HUMAN
MINT-7717137   NAF1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein kinase binding	cytosol, mitochondrial outer membrane	induction of apoptosis by extracellular signals, activation of pro-apoptotic gene products

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	75	GAVEIRSRHSSYPAGTEDDEG	RSK_group	14678993	LTP	0.32	MOD_PKA_2	-	Bcl-2_BAD	0.83	-	medium
S	99	EPSPFRGRSRSAPPNLWAAQR	RSK_group	10558990	LTP	1.00	MOD_PKB_1	-	Bcl-2_BAD	0.76	-	medium

Substrate:

C/EBP beta (Transcription factor)

Seq-ID:

P28033 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein heterodimerization activity, protein homodimerization activity, transcription activator activity, RNA polymerase II transcription factor activity, enhancer binding	cytoplasm	mammary gland epithelial cell differentiation, regulation of interleukin-6 biosynthetic process, transcription, mammary gland epithelial cell proliferation, anti-apoptosis, embryonic placenta development, brown fat cell differentiation, response to lipopolysaccharide, induction of apoptosis, positive regulation of transcription from RNA polymerase II promoter, neuron differentiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	217	AAPAKAKAKKTVDKLSDEYKM	RSK_group	11684016	LTP	0.07		-	-	0.63	-	medium

Substrate:

CREB (cAMP response element binding protein (CREB).)

Seq-ID:

P16220 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-16217   BRCA1_HUMAN
MINT-56642   SGK1_HUMAN
MINT-63231   RECQ5_HUMAN
MINT-63483   VIME_HUMAN
MINT-63485   CHD3_HUMAN
MINT-4979977   CBP_HUMAN
MINT-5209851   EP300_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein dimerization activity, transcription cofactor activity		protein amino acid phosphorylation, signal transduction, interspecies interaction between organisms, response to organic substance

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	133	KRREILSRRPSYRKILNDLSS	RSK_group	9687510	LTP	1.00		-	pKID	0.54	-	low

Substrate:

CREB (cAMP response element binding protein (CREB).)

Seq-ID:

Q01147 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-50074   MYOD1_MOUSE
MINT-2411496   SMCA5_MOUSE
MINT-4979712   CBP_MOUSE
MINT-4979756   EP300_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein dimerization activity	transcription factor complex	response to drug, regulation of cell size, positive regulation of hormone secretion, positive regulation of multicellular organism growth, lactation, axonogenesis, pituitary gland development

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	133	KRREILSRRPSYRKILNDLSS	RSK_group	15138267	LTP	1.00		-	pKID	0.54	-	medium

Substrate:

Cyclin dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor 1B (Cyclin-dependent kinase inhibitor p27) (p27Kip1))

Seq-ID:

P46527 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-17680   AKT1_HUMAN
MINT-17889   1433T_HUMAN
MINT-63858   GDIR1_HUMAN
MINT-1779946   MCM7_HUMAN
MINT-3379700   CDK2_HUMAN
MINT-3379718   CDK4_HUMAN
MINT-7219650   GRB2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cyclin-dependent protein kinase inhibitor activity, transforming growth factor beta receptor, cytoplasmic mediator activity, protein binding	cytosol, nucleus	negative regulation of kinase activity, regulation of cyclin-dependent protein kinase activity, negative regulation of cell proliferation, negative regulation of cell growth, cell cycle arrest, G1/S transition of mitotic cell cycle, autophagic cell death, cellular response to lithium ion, induction of apoptosis, negative regulation of gene-specific transcription

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	198	PKKPGLRRRQT	RSK_group	14504289	LTP	0.00		YWHAQ 14-3-3	-	0.54	-	-

Substrate:

DAP kinase 1 (Serine/threonine kinase)

Seq-ID:

P53355 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-7014569 BECN1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, ATP binding, calmodulin binding	cytoplasm, actin cytoskeleton	induction of apoptosis by extracellular signals, protein amino acid phosphorylation, apoptosis, intracellular protein kinase cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	289	DTQQALSRKASAVNMEKFKKF	RSK_group	16213824	LTP	1.00		-	-	0.37	-	medium

Substrate:

eEF-2 kinase (Elongation factor 2 kinase)

Seq-ID:

O00418 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-15495   KS6B2_HUMAN
MINT-17060   KS6A1_HUMAN
MINT-6549466   CDC2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
translation factor activity, nucleic acid binding, calcium ion binding, ATP binding, elongation factor-2 kinase activity, calmodulin binding	cytosol	protein amino acid phosphorylation, translational elongation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	366	KCGSPRVRTLSGSRPPLLRPL	RSK_group	11500364	LTP	1.00		-	-	0.69	-	medium

Substrate:

Estrogen receptor alpha (Estrogen receptor (ER) (Estradiol receptor) (ER-alpha); nuclear hormone receptor. )

Seq-ID:

P03372 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13786   BRCA1_HUMAN
MINT-50646   STA5A_HUMAN
MINT-50709   M3K1_HUMAN
MINT-5222241   NCOA1_HUMAN
MINT-6169667   EGFR_HUMAN
MINT-6614126   SMCA4_HUMAN
MINT-6614301   CHD3_HUMAN
MINT-6614361   MTA1_HUMAN
MINT-6614421   MTA2_HUMAN
MINT-6761899   PTN1_HUMAN
MINT-6761906   PTN6_HUMAN
MINT-7013584   PA1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
beta-catenin binding, nitric-oxide synthase regulator activity, estrogen response element binding, steroid binding, zinc ion binding, sequence-specific DNA binding transcription factor activity, estrogen receptor activity	chromatin remodeling complex	response to estradiol stimulus, transcription, DNA-dependent, regulation of transcription, DNA-dependent, positive regulation of retinoic acid receptor signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	118	LMLLHPPPQLSPFLQPHGQQV	RSK_group	7838153	LTP	1.00	MOD_ProDKin_1	-	Oest_recep	0.50	-	-
S	167	RRQGGRERLASTNDKGSMAME	RSK_group	7838153	LTP	0.28	MOD_PKB_1	-	Oest_recep	0.75	-	-
S	167	RRQGGRERLASTNDKGSMAME	RSK_group	11432835	LTP	0.28	MOD_PKB_1	-	Oest_recep	0.75	-	-

Substrate:

Filamin A (Anchor protein)

Seq-ID:

P21333 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13995   PSN2_HUMAN
MINT-17726   PSN1_HUMAN
MINT-48088   IKKB_HUMAN
MINT-48207   NEMO_HUMAN
MINT-48331   M3K1_HUMAN
MINT-48481   M3K3_HUMAN
MINT-49211   TAB2_HUMAN
MINT-49436   TNR1B_HUMAN
MINT-51375   ITB1_HUMAN
MINT-51381   ITB4_HUMAN
MINT-61733   SMAD3_HUMAN
MINT-72661   HS90B_HUMAN
MINT-2984809   ZO1_HUMAN
MINT-3318808   1433Z_HUMAN
MINT-4653380   CCNB2_HUMAN
MINT-5226955   ITB7_HUMAN
MINT-7244866   ABL1_HUMAN
MINT-7246834   FYN_HUMAN
MINT-7251370   P85A_HUMAN
MINT-7252714   PLCG1_HUMAN
MINT-7253290   GRB2_HUMAN
MINT-7254876   CRK_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein homodimerization activity, GTP-Ral binding, glycoprotein binding, Rac GTPase binding, transcription factor binding, signal transducer activity, actin filament binding, Fc-gamma receptor I complex binding	plasma membrane, extracellular region, cytosol, nucleus, actin cytoskeleton, cell cortex	protein stabilization, negative regulation of transcription factor activity, cytoplasmic sequestering of protein, positive regulation of I-kappaB kinase/NF-kappaB cascade, protein localization at cell surface, inhibition of adenylate cyclase activity by dopamine receptor signaling pathway, negative regulation of protein catabolic process, actin cytoskeleton reorganization, receptor clustering, positive regulation of transcription factor import into nucleus, actin crosslink formation, establishment of protein localization

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	2152	ESITRRRRAPSVANVGSHCDL	RSK_group	15024089	LTP	0.88		-	IG_FLMN	0.48	2J3S	66.39%

Substrate:

Fos (Transcription factor)

Seq-ID:

P01100 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-68804   JUN_HUMAN
MINT-68820   VE7_HPV16
MINT-1788374   JUNB_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
R-SMAD binding, specific RNA polymerase II transcription factor activity, promoter binding, sequence-specific DNA binding transcription factor activity		DNA methylation, inflammatory response, SMAD protein signal transduction, transforming growth factor beta receptor signaling pathway, cellular response to reactive oxygen species

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	362	PSCAAAHRKGSSSNEPSSDSL	RSK_group	8248197	LTP	1.00		-	-	0.58	-	low

Substrate:

GMF-beta (Glia maturation factor)

Seq-ID:

P60983 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
enzyme activator activity, protein kinase inhibitor activity, growth factor activity, actin binding, signal transducer activity	intracellular	nervous system development, protein amino acid phosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	27	KLRKFRFRKETNNAAIIMKID	RSK_group	9030586	LTP	0.31	MOD_PKA_1	-	ADF	0.19	-	medium

Substrate:

GSK-3 beta (Glycogen synthase kinase-3 beta)

Seq-ID:

P49841 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-65985   DBPA_HUMAN
MINT-65986   YBOX1_HUMAN
MINT-2837737   PSN1_HUMAN
MINT-3974216   TAU_HUMAN
MINT-4049759   PCM1_HUMAN
MINT-4049773   NIN_HUMAN
MINT-4508051   CTNB1_HUMAN
MINT-4508259   AXN1_HUMAN
MINT-4793253   P53_HUMAN
MINT-6761890   PTN1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, tau-protein kinase activity, p53 binding, beta-catenin binding, ATP binding, protein kinase A catalytic subunit binding, NF-kappaB binding	Axin-APC-beta-catenin-GSK3B complex, beta-catenin destruction complex, cytosol, nucleus	positive regulation of protein catabolic process, hippocampus development, negative regulation of apoptosis, positive regulation of protein export from nucleus, positive regulation of Rac GTPase activity, positive regulation of protein complex assembly, peptidyl-serine phosphorylation, glycogen metabolic process, superior temporal gyrus development, canonical Wnt receptor signaling pathway, ER overload response, negative regulation of protein binding, positive regulation of cell-matrix adhesion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	9	MSGRPRTTSFAESCKPVQQ	RSK_group	16039586	LTP	0.60	MOD_PKA_2	-	-	0.61	-	-

Substrate:

Lamin B receptor (lamin B receptor (from PhosphoBase))

Seq-ID:

P23913 [Gallus gallus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
receptor activity, DNA binding	nuclear inner membrane, integral to membrane

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	76	QSSSSSPSRRSRSRSRSRSPG	RSK_group	9045635	LTP	0.00	-	-	0.92	-	medium
S	78	SSSSPSRRSRSRSRSRSPGRP	RSK_group	9045635	LTP	0.16	-	-	0.93	-	medium
S	80	SSPSRRSRSRSRSRSPGRPAK	RSK_group	9045635	LTP	1.00	-	-	0.92	-	medium
S	82	PSRRSRSRSRSRSPGRPAKGR	RSK_group	9045635	LTP	1.00	-	-	0.92	-	medium
S	84	RRSRSRSRSRSPGRPAKGRRR	RSK_group	9045635	LTP	1.00	-	-	0.91	-	medium

Substrate:

NFATC4 (transcription coactivator activity)

Seq-ID:

Q14934 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-7972976 DLG4_RAT

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription coactivator activity, sequence-specific DNA binding transcription factor activity	cytoplasm, nucleus	transcription from RNA polymerase II promoter, inflammatory response, regulation of transcription, DNA-dependent, cell differentiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	676	FYVSNGRRKRSPTQSFRFLPV	RSK_group	15657420	LTP	1.00	MOD_ProDKin_1	-	IPT	0.32	-	-

Substrate:

Nitric-oxide synthase, brain (Enzyme: Synthetase)

Seq-ID:

P29476 [Rattus norvegicus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-58323 AT2B4_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
amino acid binding, protein homodimerization activity, heme binding, cadmium ion binding, enzyme binding, NADP or NADPH binding, FAD binding, calmodulin binding, nitric-oxide synthase activity, FMN binding	dendritic spine, cytosol, nuclear membrane, synapse, photoreceptor inner segment, mitochondrial outer membrane, azurophil granule, perinuclear region of cytoplasm, sarcolemma	response to organic nitrogen, negative regulation of blood pressure, response to vitamin E, oxidation reduction, response to hypoxia, response to estrogen stimulus, response to organic cyclic substance, aging, response to heat, arginine catabolic process, negative regulation of insulin secretion, nitric oxide biosynthetic process, negative regulation of heart contraction, regulation of sensory perception of pain, response to ethanol, positive regulation of vasodilation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	847	ERKSYKVRFNSVSSYSDSRKS	RSK_group	16984226	LTP	1.00		-	Flavodoxin_1	0.36	1TLL	45.90%

Substrate:

Raptor (Unclassified)

Seq-ID:

Q8N122 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-6549354 4EBP1_HUMAN
MINT-7556099 FRAP_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein complex binding	TORC1 complex, cytosol	positive regulation of TOR signaling cascade, regulation of cell size, cellular response to nutrient levels

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	719	RDSPCTPRLRSVSSYGNIRAV	RSK_group	18722121	LTP	0.12		-	-	0.38	-	medium
S	722	PCTPRLRSVSSYGNIRAVATA	RSK_group	18722121	LTP	0.20		-	-	0.34	-	medium

Substrate:

S6K-alpha 1 (Ribosomal protein S6 kinase alpha 1)

Seq-ID:

Q15418 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-17060   EF2K_HUMAN
MINT-19367   1433B_HUMAN
MINT-2793474   IF4B_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, protein serine/threonine kinase activity, ATP binding, protein binding	cytosol, nucleoplasm	protein amino acid phosphorylation, intracellular protein kinase cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	221	EAIDHEKKAYSFCGTVEYMAP	RSK_group	7642538	LTP	1.00		-	S_TKc	0.16	-	-

Substrate:

Serine/threonine-protein kinase 11 (Serine/threonine protein kinase 11)

Seq-ID:

Q15831 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-56664 SNRK_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, protein serine/threonine kinase activity, ATP binding	cytoplasm, nucleus	protein amino acid phosphorylation, cell cycle arrest, regulation of fatty acid oxidation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	428	CSASSKIRRLSACKQQ	RSK_group	11297520	LTP	1.00		-	-	0.43	-	medium

Substrate:

Serine/threonine-protein kinase 11 (Serine/threonine protein kinase 11)

Seq-ID:

Q9WTK7 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, protein serine/threonine kinase activity, LRR domain binding, ATP binding	cytoplasm, nucleus	protein amino acid phosphorylation, regulation of Wnt receptor signaling pathway, cell cycle arrest, canonical Wnt receptor signaling pathway, regulation of protein kinase B signaling cascade, negative regulation of epithelial cell proliferation involved in prostate gland development, tissue homeostasis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	431	VCSSNKIRRLSACKQQ	RSK_group	11297520	LTP	0.16	MOD_PKA_1	-	-	0.37	-	low

Substrate:

Sodium/hydrogen exchanger 1 (Membrane transport protein)

Seq-ID:

P19634 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	integral to membrane	regulation of pH, sodium ion transport

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	703	SPTMSRARIGSDPLAYEPKED	RSK_group	10400637	LTP	0.21		-	-	0.71	-	medium

Substrate:

SRF (Serum response factor)

Seq-ID:

P11831 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-15523 MYOD1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein homodimerization activity, specific RNA polymerase II transcription factor activity, transcription factor binding, sequence-specific DNA binding transcription factor activity, serum response element binding	cytoplasm, nucleus	senescence, transcription, positive regulation of cell differentiation, neuron development, regulation of smooth muscle cell differentiation, response to hormone stimulus, response to toxin, positive regulation of transcription via serum response element binding, response to cytokine stimulus, heart looping, positive regulation of smooth muscle contraction, cell migration involved in sprouting angiogenesis, muscle cell homeostasis, trophectodermal cell differentiation, angiogenesis involved in wound healing, positive regulation of transcription initiation from RNA polymerase II promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	103	AERRGLKRSLSEMEIGMVVGG	RSK_group	8413226	LTP	0.91		-	-	0.53	-	-

Substrate:

Troponin I, cardiac muscle (troponin I, cardiac muscle (from PhosphoBase))

Seq-ID:

P48787 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
actin binding		regulation of systemic arterial blood pressure by ischemic conditions, cellular calcium ion homeostasis, vasculogenesis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	23	QPAPAPVRRRSSANYRAYATE	RSK_group	15840586	LTP	0.18	MOD_PKA_1	-	-	0.73	-	-
S	24	PAPAPVRRRSSANYRAYATEP	RSK_group	15840586	LTP	0.18	MOD_PKA_1	-	-	0.72	-	-

Substrate:

Tuberin (GTPase activating protein)

Seq-ID:

P49815 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14051   1433T_HUMAN
MINT-16238   TSC1_HUMAN
MINT-16580   1433F_HUMAN
MINT-17162   1433B_HUMAN
MINT-17710   1433S_HUMAN
MINT-3317863   1433Z_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein homodimerization activity, GTPase activator activity	TSC1-TSC2 complex, Golgi apparatus, nucleus, perinuclear region of cytoplasm	neural tube closure, protein import into nucleus, regulation of insulin receptor signaling pathway, positive regulation of GTPase activity, insulin-like growth factor receptor signaling pathway, heart development, negative regulation of phosphoinositide 3-kinase cascade, superior temporal gyrus development, positive chemotaxis, protein kinase B signaling cascade, regulation of small GTPase mediated signal transduction, regulation of endocytosis, endocytosis, negative regulation of protein kinase B signaling cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1798	YEVGQRKRLISSVEDFTEFV	RSK_group	15342917	LTP	1.00		-	-	0.32	-	medium