List of substrates found:


Substrate: Abl (Proto-oncogene tyrosine-protein kinase ABL1)
Seq-ID: P00519 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16419   WASF1_HUMAN
MINT-50717   CBL_HUMAN
MINT-59466   RIN1_HUMAN
MINT-74427   EGFR_HUMAN
MINT-74429   ERBB2_HUMAN
MINT-74430   ERBB3_HUMAN
MINT-74431   ERBB4_HUMAN
MINT-1955124   KPCD_HUMAN
MINT-1955144   B2CL1_HUMAN
MINT-2831131   EP300_HUMAN
MINT-2880967   MUC1_HUMAN
MINT-3390302   ABI2_HUMAN
MINT-4508216   CTNB1_HUMAN
MINT-6787710   PTN1_HUMAN
MINT-7034009   RAD51_HUMAN
MINT-7046591   SHB_HUMAN
MINT-7213827   PRDX1_HUMAN
MINT-7213847   BRCA1_HUMAN
MINT-7214943   M4K1_MOUSE
MINT-7218198   ADA15_HUMAN
MINT-7226098   ITB2_HUMAN
MINT-7226309   TLN2_HUMAN
MINT-7226674   VAV_HUMAN
MINT-7232904   HCK_HUMAN
MINT-7243294   TRI39_HUMAN
MINT-7243330   RPP38_HUMAN
MINT-7243390   HCN2_HUMAN
MINT-7243438   NFASC_HUMAN
MINT-7243462   CENPA_HUMAN
MINT-7243522   DYN2_HUMAN
MINT-7243582   DDX41_HUMAN
MINT-7243594   TGON2_HUMAN
MINT-7243606   SF3B4_HUMAN
MINT-7243630   AKAP6_HUMAN
MINT-7243654   BAZ2A_HUMAN
MINT-7243690   ORC1_HUMAN
MINT-7243726   MLL4_HUMAN
MINT-7243738   BRCA2_HUMAN
MINT-7243798   DPOD1_HUMAN
MINT-7243810   CELR3_HUMAN
MINT-7243846   SUV92_HUMAN
MINT-7243858   KI67_HUMAN
MINT-7243870   FLNC_HUMAN
MINT-7243882   CDKL5_HUMAN
MINT-7243894   CKAP5_HUMAN
MINT-7243906   PRIC3_HUMAN
MINT-7243954   SNX8_HUMAN
MINT-7243966   EPS15_HUMAN
MINT-7243978   VP13A_HUMAN
MINT-7243990   SNX12_HUMAN
MINT-7244002   SNX17_HUMAN
MINT-7244026   CDC27_HUMAN
MINT-7244086   SPN90_HUMAN
MINT-7244098   LRBA_HUMAN
MINT-7244134   CTGE5_HUMAN
MINT-7244146   ICAL_HUMAN
MINT-7244182   FETUA_HUMAN
MINT-7244194   WNK2_HUMAN
MINT-7244206   RPGF1_HUMAN
MINT-7244230   CD2AP_HUMAN
MINT-7244302   ARHGB_HUMAN
MINT-7244314   SP1_HUMAN
MINT-7244350   OSBL5_HUMAN
MINT-7244362   RTN4_HUMAN
MINT-7244374   MED14_HUMAN
MINT-7244446   SYNJ2_HUMAN
MINT-7244482   ACAP1_HUMAN
MINT-7244494   NELFB_HUMAN
MINT-7244542   LAP2B_HUMAN
MINT-7244554   P2RX7_HUMAN
MINT-7244566   FYB_HUMAN
MINT-7244602   E41L3_HUMAN
MINT-7244614   SNX3_HUMAN
MINT-7244626   GT2D1_HUMAN
MINT-7244638   DYN1_HUMAN
MINT-7244650   ASAP1_HUMAN
MINT-7244662   G3BP2_HUMAN
MINT-7244674   DNLI3_HUMAN
MINT-7244698   DLGP4_HUMAN
MINT-7244746   BRPF3_HUMAN
MINT-7244806   M4K1_HUMAN
MINT-7244830   CUL7_HUMAN
MINT-7244866   FLNA_HUMAN
MINT-7244878   RIMS1_HUMAN
MINT-7245034   SRC_HUMAN
MINT-7246522   FYN_HUMAN
MINT-7249642   NCK1_HUMAN
MINT-7251418   P85A_HUMAN
MINT-7252738   PLCG1_HUMAN
MINT-7253218   GRB2_HUMAN
MINT-7254106   CRK_HUMAN
MINT-7297574   MAVS_HUMAN
MINT-7301011   TOP1_HUMAN
MINT-7309761   P73_HUMAN
MINT-7385614   3BP1_MOUSE
MINT-7385781   ABI1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
magnesium ion binding,
manganese ion binding,
DNA binding,
protein C-terminus binding,
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
proline-rich region binding		 cytosol,
nuclear membrane,
cytoskeleton,
nucleolus,
perinuclear region of cytoplasm		 regulation of transcription involved in S phase of mitotic cell cycle,
mismatch repair,
actin cytoskeleton organization,
signal transduction,
cell adhesion,
peptidyl-tyrosine phosphorylation,
positive regulation of oxidoreductase activity,
DNA damage response, signal transduction resulting in induction of apoptosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 735 GAKDTEWRSVTLPRDLQSTGR TTK 18794806
LTP
1.00
 - -
0.74
 --

Substrate: CDCA8 (protein binding)
Seq-ID: Q53HL2 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-4509524   BIRC5_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein binding spindle,
chromosome, centromeric region,
chromosome passenger complex,
cytoplasm,
nucleolus		 chromosome organization,
cell division,
mitotic metaphase
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 88 GNKQALEEAATADLDITEINK TTK 19530738
LTP
0.95
 - Borealin
0.44
 - medium
T 88 GNKQALEEAATADLDITEINK TTK 18243099
LTP
0.95
 - Borealin
0.44
 - medium
T 94 EEAATADLDITEINKLTAEAI TTK 19530738
LTP
0.14
 - Borealin
0.41
 - medium
T 94 EEAATADLDITEINKLTAEAI TTK 18243099
LTP
0.14
 - Borealin
0.41
 - medium
T 169 GKGKRSSRANTVTPAVGRLEV TTK 19530738
LTP
0.45
 - Borealin
0.62
 - medium
T 169 GKGKRSSRANTVTPAVGRLEV TTK 18243099
LTP
0.45
 - Borealin
0.62
 - medium
T 230 PLADSKEIFLTVPVGGGESLR TTK 19530738
LTP
0.45
 - Borealin
0.40
 - medium
T 230 PLADSKEIFLTVPVGGGESLR TTK 18243099
LTP
0.45
 - Borealin
0.40
 - medium

Substrate: CHK2 (Serine/threonine-protein kinase Chk2)
Seq-ID: O96017 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13742   P53_HUMAN
MINT-15591   MPIP1_HUMAN
MINT-49652   NBN_HUMAN
MINT-58599   MDM2_HUMAN
MINT-62311   IMA2_HUMAN
MINT-4793727   RB_HUMAN
MINT-6806274   STRAP_HUMAN
MINT-7294980   XRCC1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
metal ion binding,
ATP binding,
protein binding		 PML body protein amino acid phosphorylation,
senescence,
cell cycle,
DNA damage checkpoint,
DNA damage response, signal transduction resulting in induction of apoptosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 68 GTLSSLETVSTQELYSIPEDQ TTK 15618221
LTP
0.08
 MOD_PIKK_1
 MDC1 FHA;
PLK1 PBD		 -
0.61
 --

Substrate: Heat shock 70 kDa protein 9
Seq-ID: P38646 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-48070   IKKB_HUMAN
MINT-48096   IKKE_HUMAN
MINT-48142   NEMO_HUMAN
MINT-48251   TANK_HUMAN
MINT-48283   M3K1_HUMAN
MINT-48392   M3K3_HUMAN
MINT-48645   NFKB1_HUMAN
MINT-48701   NFKB2_HUMAN
MINT-48793   M3K14_HUMAN
MINT-48982   RELB_HUMAN
MINT-49042   RIPK1_HUMAN
MINT-49164   TAB1_HUMAN
MINT-49187   TAB2_HUMAN
MINT-49255   TBK1_HUMAN
MINT-49380   TNR1B_HUMAN
MINT-3319320   1433Z_HUMAN
MINT-7557644   P53_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
unfolded protein binding,
ATP binding		 mitochondrial nucleoid,
cell surface		 protein folding,
anti-apoptosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 62 KGAVVGIDLGTTNSCVAVMEG TTK 17573779
LTP
1.00
 - HSP70
0.27
 - medium
S 65 VVGIDLGTTNSCVAVMEGKQA TTK 17573779
LTP
1.00
 - HSP70
0.31
 - medium

Substrate: p53 (Cellular tumor antigen p53)
Seq-ID: P04637 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13742   CHK2_HUMAN
MINT-15878   UBP7_HUMAN
MINT-16161   BRCA1_HUMAN
MINT-16977   PARP1_HUMAN
MINT-19990   PIN1_HUMAN
MINT-24859   ASPP2_HUMAN
MINT-45889   CEBPZ_HUMAN
MINT-49767   ATM_HUMAN
MINT-50577   SAE1_HUMAN
MINT-56524   SP1_HUMAN
MINT-58470   MED1_HUMAN
MINT-58672   HNRL1_HUMAN
MINT-60094   HIPK2_HUMAN
MINT-61312   MK08_HUMAN
MINT-61317   WWOX_HUMAN
MINT-62206   PP1A_HUMAN
MINT-63290   ARI2_HUMAN
MINT-63365   KITH_HUMAN
MINT-63497   ZNF24_HUMAN
MINT-63537   IF2B_HUMAN
MINT-63547   RAB4A_HUMAN
MINT-63559   SAT1_HUMAN
MINT-64119   STX5_HUMAN
MINT-64188   MD2BP_HUMAN
MINT-64748   K0087_HUMAN
MINT-65132   HSPB1_HUMAN
MINT-65272   MPH6_HUMAN
MINT-68565   BMX_HUMAN
MINT-74886   NPM_HUMAN
MINT-74925   1433Z_HUMAN
MINT-1795431   NMT1_HUMAN
MINT-1891378   CDN1A_HUMAN
MINT-1958329   CHK1_HUMAN
MINT-2634790   RGRF1_HUMAN
MINT-2858243   DVL2_HUMAN
MINT-2866927   SCAM1_HUMAN
MINT-3390028   KC1D_RAT
MINT-3979604   P53_MOUSE
MINT-4049689   NR4A1_HUMAN
MINT-4052116   SYVN1_HUMAN
MINT-4052873   GRP78_HUMAN
MINT-4302642   HS71L_HUMAN
MINT-4303978   XPO1_HUMAN
MINT-4329805   TOPRS_HUMAN
MINT-4793180   EGR1_HUMAN
MINT-4793253   GSK3B_HUMAN
MINT-4793489   PML_HUMAN
MINT-5114724   ZN363_HUMAN
MINT-5207405   HDAC8_HUMAN
MINT-6540866   PSME3_HUMAN
MINT-6540889   MDM2_HUMAN
MINT-6628692   LT_SV40
MINT-6665320   CBP_HUMAN
MINT-6701342   MAP1B_HUMAN
MINT-7013631   PA1_HUMAN
MINT-7013916   RYBP_HUMAN
MINT-7103733   ANDR_HUMAN
MINT-7144912   TOE1_HUMAN
MINT-7222784   FRAP_HUMAN
MINT-7263630   EP300_HUMAN
MINT-7266250   PLK1_HUMAN
MINT-7294020   FAK1_HUMAN
MINT-7295816   IKKB_HUMAN
MINT-7557644   GRP75_HUMAN
MINT-7711943   1433S_HUMAN
MINT-7717378   PHB_HUMAN
MINT-7718917   SNAI1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription activator activity,
protease binding,
DNA strand annealing activity,
chromatin binding,
copper ion binding,
ATP binding,
transcription factor binding,
chaperone binding,
zinc ion binding,
histone acetyltransferase binding,
promoter binding,
sequence-specific DNA binding transcription factor activity,
protein N-terminus binding,
protein heterodimerization activity,
protein phosphatase 2A binding,
protein kinase binding,
ubiquitin protein ligase binding		 nucleolus,
nuclear matrix,
insoluble fraction,
protein complex,
endoplasmic reticulum,
PML body,
mitochondrion		 positive regulation of gene-specific transcription from RNA polymerase II promoter,
senescence,
mitotic cell cycle G1/S DNA damage checkpoint,
cell cycle arrest,
regulation of mitochondrial membrane permeability,
response to gamma radiation,
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator,
response to tumor cell,
ER overload response,
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis,
interspecies interaction between organisms,
Ras protein signal transduction,
nucleotide-excision repair,
protein tetramerization,
cellular response to glucose starvation,
negative regulation of helicase activity,
negative regulation of cell growth,
base-excision repair,
activation of caspase activity by cytochrome c,
cell aging
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 18 PSVEPPLSQETFSDLWKLLPE TTK 19332559
LTP
1.00
 MOD_CK1_1
 - P53_TAD
0.64
 --

Substrate: TTK (Dual specificity protein kinase)
Seq-ID: P33981-1 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
identical protein binding,
ATP binding,
protein tyrosine kinase activity		 spindle positive regulation of cell proliferation,
protein amino acid phosphorylation,
positive regulation of pathway-restricted SMAD protein phosphorylation,
mitotic spindle organization,
mitotic cell cycle spindle assembly checkpoint
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 676 GIANQMQPDTTSVVKDSQVGT TTK 19120698
LTP
 - - S_TKc
0.43
 --
T 676 GIANQMQPDTTSVVKDSQVGT TTK 18680479
LTP
 - - S_TKc
0.43
 --
T 676 GIANQMQPDTTSVVKDSQVGT TTK 18083840
LTP
 - - S_TKc
0.43
 --
T 676 GIANQMQPDTTSVVKDSQVGT TTK 18545697
LTP
 - - S_TKc
0.43
 --
T 686 TSVVKDSQVGTVNYMPPEAIK TTK 19120698
LTP
 - - S_TKc
0.39
 3CEK 43.84%

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