Substrate: Hsp60 (Mitochondrial matrix protein import)
Seq-ID: P10809 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-48241   NEMO_HUMAN
MINT-3305086   1433Z_HUMAN
MINT-7965777   MCL1_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
lipopolysaccharide binding,
ATPase activity,
p53 binding,
unfolded protein binding,
DNA replication origin binding,
ATP binding,
chaperone binding,
single-stranded DNA binding,
cell surface binding		 coated vesicle,
early endosome,
cytosol,
coated pit,
cell surface,
lipopolysaccharide receptor complex,
mitochondrial inner membrane,
extracellular space,
stored secretory granule,
mitochondrial matrix		 protein stabilization,
`de novo` protein folding,
response to unfolded protein,
protein maturation,
activation of caspase activity,
positive regulation of T cell mediated immune response to tumor cell,
positive regulation of apoptosis,
positive regulation of T cell activation,
protein refolding,
positive regulation of interleukin-12 production,
isotype switching to IgG isotypes,
interspecies interaction between organisms,
positive regulation of interferon-gamma production,
positive regulation of macrophage activation,
positive regulation of interleukin-10 production,
B cell cytokine production,
MyD88-dependent toll-like receptor signaling pathway,
B cell proliferation,
positive regulation of interferon-alpha production,
negative regulation of apoptosis,
T cell activation,
positive regulation of interleukin-6 production,
chaperone-mediated protein complex assembly
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 70 RTVIIEQSWGSPKVTKDGVTV - 16964243
HTP
0.87
 - Cpn60_TCP1
0.36
 - low
S 70 RTVIIEQSWGSPKVTKDGVTV - 18669648
HTP
0.87
 - Cpn60_TCP1
0.36
 - low
Y 227 MKFDRGYISPYFINTSKGQKC - 15592455
HTP
1.00
 - Cpn60_TCP1
0.22
 - low

Substrate: Hsp60 (Mitochondrial matrix protein import)
Seq-ID: P63038 [Mus musculus]
Download:fasta csv
Interaction Network(s):
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-7965736   MCL1_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
lipopolysaccharide binding,
ATP binding		 mitochondrial matrix,
plasma membrane part,
mitochondrial inner membrane,
stored secretory granule		 T cell activation,
positive regulation of T cell activation,
positive regulation of interferon-gamma production,
positive regulation of interferon-alpha production
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 223 IIEGMKFDRGYISPYFINTSK - 17203969
HTP
0.96
 - Cpn60_TCP1
0.17
 - low

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