List of substrates found:

PDGF-R alpha  ZAP70  CBL E3 ubiquitin protein ligase  P130Cas  Paxillin  Gab1  SOCS3  Epo-R  CAS-L  Insulin R  Crk-like protein  Disabled homolog 1  STAT 5  p62DOK 


Substrate: PDGF-R alpha (Receptor tyrosine kinase)
Seq-ID: P16234 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
platelet-derived growth factor alpha-receptor activity,
vascular endothelial growth factor receptor activity,
platelet-derived growth factor binding,
protein homodimerization activity,
platelet-derived growth factor receptor binding,
ATP binding		 integral to plasma membrane positive regulation of DNA replication,
positive regulation of fibroblast proliferation,
cell activation,
positive regulation of cell migration,
protein amino acid autophosphorylation,
peptidyl-tyrosine phosphorylation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 762 SKYSDIQRSLYDRPASYKKKS PDGFR_alpha 9546424
LTP
1.00
 CRKL SH2;
CRK SH2		 TyrKc
0.29
 - medium
Y 762 SKYSDIQRSLYDRPASYKKKS - 18083107
HTP
1.00
 CRKL SH2;
CRK SH2		 TyrKc
0.29
 - medium

Substrate: ZAP70 (Cytoplasmic tyrosine kinase)
Seq-ID: P43403 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-59476   LCK_HUMAN
MINT-60980   SHC1_HUMAN
MINT-74806   ERBB3_HUMAN
MINT-74807   EGFR_HUMAN
MINT-3374106   HS90A_HUMAN
MINT-3382488   LAT_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
non-membrane spanning protein tyrosine kinase activity,
ATP binding		 cytosol,
T cell receptor complex		 positive thymic T cell selection,
immune response,
intracellular protein kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 292 RRIDTLNSDGYTPEPARITSP Lck 8756661
LTP
1.00
 CBL PTB;
CBL SH2;
CRKL SH2		 -
0.65
 --
Y 292 RRIDTLNSDGYTPEPARITSP ZAP70 8756661
LTP
1.00
 CBL PTB;
CBL SH2;
CRKL SH2		 -
0.65
 --
Y 292 RRIDTLNSDGYTPEPARITSP Lck 7961936
LTP
1.00
 CBL PTB;
CBL SH2;
CRKL SH2		 -
0.65
 --
Y 292 RRIDTLNSDGYTPEPARITSP ZAP70 7961936
LTP
1.00
 CBL PTB;
CBL SH2;
CRKL SH2		 -
0.65
 --
Y 292 RRIDTLNSDGYTPEPARITSP - 15144186
HTP
1.00
 CBL PTB;
CBL SH2;
CRKL SH2		 -
0.65
 --
Y 292 RRIDTLNSDGYTPEPARITSP - 15592455
HTP
1.00
 CBL PTB;
CBL SH2;
CRKL SH2		 -
0.65
 --
Y 292 RRIDTLNSDGYTPEPARITSP - 16094384
HTP
1.00
 CBL PTB;
CBL SH2;
CRKL SH2		 -
0.65
 --
Y 292 RRIDTLNSDGYTPEPARITSP - 15659558
HTP
1.00
 CBL PTB;
CBL SH2;
CRKL SH2		 -
0.65
 --
Y 292 RRIDTLNSDGYTPEPARITSP - 17192257
HTP
1.00
 CBL PTB;
CBL SH2;
CRKL SH2		 -
0.65
 --
Y 315 PRPMPMDTSVYESPYSDPEEL ZAP70 11828374
LTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL ZAP70 7798261
LTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL - 12522270
HTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL - 15592455
HTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL - 16094384
HTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL ZAP70 10037717
LTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%
Y 319 PMDTSVYESPYSDPEELKDKK - 10202147
LTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 10318843
LTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 12522270
HTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 15592455
HTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 16094384
HTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 10037717
LTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 15268851
LTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 15292262
LTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%

Substrate: CBL E3 ubiquitin protein ligase (Adaptor molecule)
Seq-ID: P22681 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-15516   LCK_HUMAN
MINT-15716   CRK_HUMAN
MINT-16022   CD2AP_HUMAN
MINT-16347   LYN_HUMAN
MINT-16846   LCP2_HUMAN
MINT-17062   FCGR1_HUMAN
MINT-17932   NCK1_HUMAN
MINT-50666   FYN_HUMAN
MINT-50717   ABL1_HUMAN
MINT-50722   CRKL_HUMAN
MINT-58331   ITCH_HUMAN
MINT-60970   RET_HUMAN
MINT-60973   EGFR_HUMAN
MINT-60978   SHC1_HUMAN
MINT-68500   P85A_HUMAN
MINT-2837344   PLCG1_BOVIN
MINT-4299918   ASAP1_HUMAN
MINT-6169713   SPY1_HUMAN
MINT-6170244   SH3G2_HUMAN
MINT-6538940   SPY4_HUMAN
MINT-6538977   KSYK_HUMAN
MINT-6539587   MET_HUMAN
MINT-6539601   SPY2_HUMAN
MINT-6539646   VGFR1_HUMAN
MINT-6539679   RON_HUMAN
MINT-6539730   SRC_HUMAN
MINT-7040249   GRB2_HUMAN
MINT-7046364   ITSN1_HUMAN
MINT-7103623   MK08_HUMAN
MINT-7211864   ARHG7_HUMAN
MINT-7214822   FYN_MOUSE
MINT-7218352   SH3K1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
calcium ion binding,
zinc ion binding,
sequence-specific DNA binding transcription factor activity,
signal transducer activity,
ubiquitin-protein ligase activity		 cytosol,
nucleus		 epidermal growth factor receptor signaling pathway,
positive regulation of receptor-mediated endocytosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 337 ALIDGFREGFYLFPDGRNQNP - 10608804
LTP
1.00
 CRKL SH2;
CRK SH2;
PIK3R2 SH2		 Cbl_N3
0.18
 1YVH 9.61%
Y 674 IKPSSSANAIYSLAARPLPVP - 12522270
HTP
0.25
 CRKL SH2;
PLCG1 SH2		 -
0.55
 --
Y 674 IKPSSSANAIYSLAARPLPVP - 15144186
HTP
0.25
 CRKL SH2;
PLCG1 SH2		 -
0.55
 --
Y 674 IKPSSSANAIYSLAARPLPVP - 15592455
HTP
0.25
 CRKL SH2;
PLCG1 SH2		 -
0.55
 --
Y 674 IKPSSSANAIYSLAARPLPVP - 15922744
LTP
0.25
 CRKL SH2;
PLCG1 SH2		 -
0.55
 --
Y 700 EQCEGEEDTEYMTPSSRPLRP Fyn 9525940
LTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 700 EQCEGEEDTEYMTPSSRPLRP SYK 9525940
LTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 700 EQCEGEEDTEYMTPSSRPLRP Yes 9525940
LTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 700 EQCEGEEDTEYMTPSSRPLRP - 9102067
LTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 700 EQCEGEEDTEYMTPSSRPLRP - 12522270
HTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 700 EQCEGEEDTEYMTPSSRPLRP INSR 11997497
LTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 700 EQCEGEEDTEYMTPSSRPLRP - 10829062
LTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 700 EQCEGEEDTEYMTPSSRPLRP - 15922744
LTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 731 DCDQQIDSCTYEAMYNIQSQA Fyn 9525940
LTP
0.29
 CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2		 -
0.47
 --
Y 731 DCDQQIDSCTYEAMYNIQSQA SYK 9525940
LTP
0.29
 CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2		 -
0.47
 --
Y 731 DCDQQIDSCTYEAMYNIQSQA Yes 9525940
LTP
0.29
 CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2		 -
0.47
 --
Y 731 DCDQQIDSCTYEAMYNIQSQA - 10934191
LTP
0.29
 CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2		 -
0.47
 --
Y 731 DCDQQIDSCTYEAMYNIQSQA Fyn 9890970
LTP
0.29
 CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2		 -
0.47
 --
Y 731 DCDQQIDSCTYEAMYNIQSQA - 12604776
LTP
0.29
 CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2		 -
0.47
 --
Y 731 DCDQQIDSCTYEAMYNIQSQA - 15922744
LTP
0.29
 CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2		 -
0.47
 --
Y 774 PEESENEDDGYDVPKPPVPAV Fyn 9525940
LTP
0.28
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.89
 --
Y 774 PEESENEDDGYDVPKPPVPAV SYK 9525940
LTP
0.28
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.89
 --
Y 774 PEESENEDDGYDVPKPPVPAV Yes 9525940
LTP
0.28
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.89
 --
Y 774 PEESENEDDGYDVPKPPVPAV - 12522270
HTP
0.28
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.89
 --
Y 774 PEESENEDDGYDVPKPPVPAV - 12604776
LTP
0.28
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.89
 --
Y 774 PEESENEDDGYDVPKPPVPAV - 10829062
LTP
0.28
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.89
 --
Y 774 PEESENEDDGYDVPKPPVPAV - 15922744
LTP
0.28
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.89
 --

Substrate: P130Cas (Adaptor molecule. Contain 15 YxxP motifs. )
Seq-ID: P56945 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-74936   PTN12_HUMAN
MINT-74938   FAK1_HUMAN
MINT-3974941   1433S_HUMAN
MINT-6174734   ACTB_HUMAN
MINT-6763936   CRK_HUMAN
MINT-6793484   PTN1_HUMAN
MINT-7104353   CDC42_HUMAN
MINT-7104422   SRC_HUMAN
MINT-7104436   ACK1_HUMAN
MINT-7247002   FYN_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
protein kinase binding,
protein phosphatase binding,
signal transducer activity		 focal adhesion,
membrane fraction,
cytosol,
ruffle		 regulation of cell growth,
B cell receptor signaling pathway,
cell division,
positive regulation of cell migration,
nerve growth factor receptor signaling pathway,
cell migration,
integrin-mediated signaling pathway,
epidermal growth factor receptor signaling pathway,
actin filament organization,
regulation of apoptosis,
platelet-derived growth factor receptor signaling pathway,
T cell receptor signaling pathway,
cell adhesion,
insulin receptor signaling pathway,
cell proliferation,
G-protein coupled receptor protein signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 128 PTPSKAQQGLYQVPGPSPQFQ FGFR1 12601080
LTP
 - CRKL SH2;
CRK SH2		 -
0.76
 - medium
Y 128 PTPSKAQQGLYQVPGPSPQFQ - 18083107
HTP
 - CRKL SH2;
CRK SH2		 -
0.76
 - medium
Y 128 PTPSKAQQGLYQVPGPSPQFQ - 16212419
HTP
 - CRKL SH2;
CRK SH2		 -
0.76
 - medium
Y 165 HPFPSPATDLYQVPPGPGGPA - 15817476
LTP
1.00
 CRKL SH2;
CRK SH2		 -
0.85
 - medium
Y 234 YEAAQPEQDEYDIPRHLLAPG - 18083107
HTP
1.00
 CRKL SH2;
CRK SH2		 -
0.71
 - medium
Y 234 YEAAQPEQDEYDIPRHLLAPG - 16212419
HTP
1.00
 CRKL SH2;
CRK SH2		 -
0.71
 - medium
Y 249 HLLAPGPQDIYDVPPVRGLLP FGFR1 12601080
LTP
1.00
 ABL1 SH2;
CRKL SH2;
CRK SH2		 -
0.56
 - medium
Y 249 HLLAPGPQDIYDVPPVRGLLP - 18083107
HTP
1.00
 ABL1 SH2;
CRKL SH2;
CRK SH2		 -
0.56
 - medium
Y 249 HLLAPGPQDIYDVPPVRGLLP - 16212419
HTP
1.00
 ABL1 SH2;
CRKL SH2;
CRK SH2		 -
0.56
 - medium
Y 306 GLPPSNHHAVYDVPPSVSKDV FGFR1 12601080
LTP
0.94
 ABL1 SH2;
CRKL SH2;
CRK SH2		 -
0.73
 - medium
Y 327 PDGPLLREETYDVPPAFAKAK FGFR1 12601080
LTP
1.00
 CRKL SH2;
CRK SH2		 -
0.61
 - medium
Y 387 GLRRPGPGTLYDVPRERVLPP - 15316024
LTP
0.02
 CRKL SH2;
CRK SH2		 -
0.73
 - medium
Y 387 GLRRPGPGTLYDVPRERVLPP - 18083107
HTP
0.02
 CRKL SH2;
CRK SH2		 -
0.73
 - medium
Y 387 GLRRPGPGTLYDVPRERVLPP - 16212419
HTP
0.02
 CRKL SH2;
CRK SH2		 -
0.73
 - medium
Y 410 ADGGVVDSGVYAVPPPAEREA FGFR1 12601080
LTP
1.00
 ABL1 SH2;
CRKL SH2;
CRK SH2		 -
0.72
 - medium

Substrate: Paxillin (Cytoskeletal protein; component of focal adhesion.)
Seq-ID: P49023 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-1953339   GIT1_HUMAN
MINT-1953360   GIT2_HUMAN
MINT-6169431   CSK_HUMAN
MINT-6169440   PTN11_HUMAN
MINT-6169502   GAB1_HUMAN
MINT-6763928   CRK_HUMAN
MINT-7145479   ASAP1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
beta-catenin binding,
vinculin binding,
zinc ion binding		 focal adhesion,
cytoplasm,
microtubule associated complex,
lamellipodium		 muscle contraction,
signal complex assembly,
signal transduction,
cell-matrix adhesion,
cellular response to reactive oxygen species
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 31 RPVFLSEETPYSYPTGNHTYQ FAK 7537852
LTP
1.00
 CRKL SH2;
CRK SH2		 -
0.57
 - low
Y 31 RPVFLSEETPYSYPTGNHTYQ - 11774284
LTP
1.00
 CRKL SH2;
CRK SH2		 -
0.57
 - low
Y 31 RPVFLSEETPYSYPTGNHTYQ - 10823820
LTP
1.00
 CRKL SH2;
CRK SH2		 -
0.57
 - low
Y 31 RPVFLSEETPYSYPTGNHTYQ - 15107421
LTP
1.00
 CRKL SH2;
CRK SH2		 -
0.57
 - low
Y 31 RPVFLSEETPYSYPTGNHTYQ - 16254239
HTP
1.00
 CRKL SH2;
CRK SH2		 -
0.57
 - low
Y 31 RPVFLSEETPYSYPTGNHTYQ - 15817476
LTP
1.00
 CRKL SH2;
CRK SH2		 -
0.57
 - low
Y 31 RPVFLSEETPYSYPTGNHTYQ Brk 15572663
LTP
1.00
 CRKL SH2;
CRK SH2		 -
0.57
 - low
Y 31 RPVFLSEETPYSYPTGNHTYQ FAK 12408869
LTP
1.00
 CRKL SH2;
CRK SH2		 -
0.57
 - low
Y 118 CSRVGEEEHVYSFPNKQKSAE FAK 7537852
LTP
0.93
 CRKL SH2;
CRK SH2;
Csk SH2		 Paxillin
0.73
 - low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 11774284
LTP
0.93
 CRKL SH2;
CRK SH2;
Csk SH2		 Paxillin
0.73
 - low
Y 118 CSRVGEEEHVYSFPNKQKSAE FAK 7615549
LTP
0.93
 CRKL SH2;
CRK SH2;
Csk SH2		 Paxillin
0.73
 - low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 15592455
HTP
0.93
 CRKL SH2;
CRK SH2;
Csk SH2		 Paxillin
0.73
 - low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 15107421
LTP
0.93
 CRKL SH2;
CRK SH2;
Csk SH2		 Paxillin
0.73
 - low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 16254239
HTP
0.93
 CRKL SH2;
CRK SH2;
Csk SH2		 Paxillin
0.73
 - low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 16094384
HTP
0.93
 CRKL SH2;
CRK SH2;
Csk SH2		 Paxillin
0.73
 - low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 15817476
LTP
0.93
 CRKL SH2;
CRK SH2;
Csk SH2		 Paxillin
0.73
 - low
Y 118 CSRVGEEEHVYSFPNKQKSAE Brk 15572663
LTP
0.93
 CRKL SH2;
CRK SH2;
Csk SH2		 Paxillin
0.73
 - low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 18083107
HTP
0.93
 CRKL SH2;
CRK SH2;
Csk SH2		 Paxillin
0.73
 - low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 18669648
HTP
0.93
 CRKL SH2;
CRK SH2;
Csk SH2		 Paxillin
0.73
 - low

Substrate: Gab1 (Multisubstrate docking protein downstream in the signaling pathways of different RTK.)
Seq-ID: Q13480 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-58395   GRB2_HUMAN
MINT-58403   GRAP2_HUMAN
MINT-58404   MET_HUMAN
MINT-68564   BMX_HUMAN
MINT-1893011   P85A_HUMAN
MINT-6169406   PTN11_HUMAN
MINT-6169502   PAXI_HUMAN
MINT-7971128   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3/SH2 adaptor activity cytosol epidermal growth factor receptor signaling pathway,
insulin receptor signaling pathway,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 242 MNGFFQQQMIYDSPPSRAPSA INSR 10978177
LTP
1.00
 CRKL SH2;
CRK SH2;
NCK SH2		 -
0.65
 - low
Y 259 APSASVDSSLYNLPRSYSHDV - 12522270
HTP
0.15
 CRKL SH2;
CRK SH2		 -
0.59
 - low
Y 307 ETQMRHVSISYDIPPTPGNTY Met 10734310
LTP
0.12
 CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2		 -
0.70
 - low
Y 307 ETQMRHVSISYDIPPTPGNTY EGFR 10734310
LTP
0.12
 CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2		 -
0.70
 - low
Y 317 YDIPPTPGNTYQIPRTFPEGT - 16497976
HTP
0.24
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
RASA_group SH2		 -
0.74
 - low
Y 373 PRTASDTDSSYCIPTAGMSPS INSR 10978177
LTP
0.08
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.66
 - low
Y 373 PRTASDTDSSYCIPTAGMSPS EGFR 9890893
LTP
0.08
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.66
 - low
Y 373 PRTASDTDSSYCIPTAGMSPS - 10753869
LTP
0.08
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.66
 - low
Y 373 PRTASDTDSSYCIPTAGMSPS Met 10734310
LTP
0.08
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.66
 - low
Y 406 LRKDASSQDCYDIPRAFPSDR EGFR 9890893
LTP
1.00
 CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2;
SHC_group SH2		 -
0.61
 - low
Y 406 LRKDASSQDCYDIPRAFPSDR - 10753869
LTP
1.00
 CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2;
SHC_group SH2		 -
0.61
 - low
Y 406 LRKDASSQDCYDIPRAFPSDR Met 10734310
LTP
1.00
 CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2;
SHC_group SH2		 -
0.61
 - low
Y 406 LRKDASSQDCYDIPRAFPSDR - 18083107
HTP
1.00
 CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2;
SHC_group SH2		 -
0.61
 - low

Substrate: SOCS3 (protein kinase inhibitor activity)
Seq-ID: O14543 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
MINT-63063   PIN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein kinase inhibitor activity regulation of growth,
negative regulation of signal transduction,
anti-apoptosis,
JAK-STAT cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 221 PGPIREFLDQYDAPL       - 12783885
LTP
0.99
 CRKL SH2;
NCK SH2;
RASA_group SH2		 SOCS_box
0.43
 --
Y 221 PGPIREFLDQYDAPL       Lck 15173187
LTP
0.99
 CRKL SH2;
NCK SH2;
RASA_group SH2		 SOCS_box
0.43
 --

Substrate: Epo-R (Receptor for erythropoietin, a major activator of erythropoiesis)
Seq-ID: P19235 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-73504   PTN6_HUMAN
MINT-74896   PTN6_MOUSE
MINT-6794748   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
erythropoietin receptor activity extracellular region,
integral to plasma membrane
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 456 PPTPPHLKYLYLVVSDSGIST - 10579919
LTP
1.00
 CISH SH2;
CRKL SH2;
INPP5D SH2;
PLCG2 SH2;
SOCS3 SH2;
STAT5 SH2		 -
0.36
 - low
Y 456 PPTPPHLKYLYLVVSDSGIST - 11443118
LTP
1.00
 CISH SH2;
CRKL SH2;
INPP5D SH2;
PLCG2 SH2;
SOCS3 SH2;
STAT5 SH2		 -
0.36
 - low
Y 456 PPTPPHLKYLYLVVSDSGIST - 12027890
LTP
1.00
 CISH SH2;
CRKL SH2;
INPP5D SH2;
PLCG2 SH2;
SOCS3 SH2;
STAT5 SH2		 -
0.36
 - low

Substrate: CAS-L (Docking protein)
Seq-ID: Q14511 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-50139   ITCH_HUMAN
MINT-62009   SMAD1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein binding focal adhesion,
spindle,
lamellipodium,
Golgi apparatus,
nucleus,
cell cortex		 cell division,
regulation of growth,
integrin-mediated signaling pathway,
signal transduction,
actin filament bundle assembly,
mitosis,
cell adhesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 166 TPVRTGHGYVYEYPSRYQKDV - 12522270
HTP
1.00
 ABL1 SH2;
CRKL SH2;
CRK SH2;
NCK SH2		 -
0.43
 - medium
Y 317 GQSVGSQNDAYDVPRGVQFLE - 18083107
HTP
1.00
 ABL1 SH2;
CRKL SH2;
CRK SH2;
NCK SH2		 -
0.70
 - medium
Y 345 KANPQERDGVYDVPLHNPPDA - 18083107
HTP
1.00
 ABL1 SH2;
CRKL SH2;
CRK SH2;
NCK SH2		 -
0.86
 - medium

Substrate: Insulin R (Receptor tyrosine kinase)
Seq-ID: P06213 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16516   GRB10_HUMAN
MINT-16842   MD2L1_HUMAN
MINT-18199   IRS2_HUMAN
MINT-19010   IRS1_HUMAN
MINT-73466   GRB10_MOUSE
MINT-6793537   INSR_RAT
MINT-6794075   IRS1_MOUSE
MINT-6794090   INSR_MOUSE
MINT-6794946   PTN1_HUMAN
MINT-6795115   IRS1_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
insulin-like growth factor receptor binding,
insulin binding,
PTB domain binding,
GTP binding,
metal ion binding,
insulin receptor substrate binding,
ATP binding,
insulin-like growth factor I binding,
insulin receptor activity,
SH2 domain binding,
phosphoinositide 3-kinase binding,
insulin-like growth factor II binding,
receptor signaling protein tyrosine kinase activity		 microsome,
caveola,
insulin receptor complex,
endosome membrane		 positive regulation of glycolysis,
positive regulation of MAPKKK cascade,
positive regulation of developmental growth,
regulation of embryonic development,
heart morphogenesis,
positive regulation of cell migration,
carbohydrate metabolic process,
protein heterotetramerization,
positive regulation of protein kinase B signaling cascade,
protein amino acid autophosphorylation,
activation of MAPK activity,
positive regulation of glycogen biosynthetic process,
positive regulation of mitosis,
peptidyl-tyrosine phosphorylation,
positive regulation of glucose import,
positive regulation of respiratory burst,
activation of protein kinase B activity,
G-protein coupled receptor protein signaling pathway,
positive regulation of DNA replication,
positive regulation of protein amino acid phosphorylation,
positive regulation of cell proliferation,
glucose homeostasis,
positive regulation of nitric oxide biosynthetic process,
transformation of host cell by virus,
regulation of gene-specific transcription
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 999 GPLYASSNPEYLSASDVFPCS INSR 8662806
LTP
1.00
 CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2		 -
0.11
 --
Y 999 GPLYASSNPEYLSASDVFPCS INSR 1658004
LTP
1.00
 CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2		 -
0.11
 --
Y 999 GPLYASSNPEYLSASDVFPCS - 8393870
LTP
1.00
 CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2		 -
0.11
 --
Y 999 GPLYASSNPEYLSASDVFPCS INSR 10340378
LTP
1.00
 CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2		 -
0.11
 --

Substrate: Crk-like protein (Crk-like protein)
Seq-ID: P46109 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-50722   CBL_HUMAN
MINT-58390   GAB1_MOUSE
MINT-61486   EGFR_HUMAN
MINT-61525   ERBB4_HUMAN
MINT-74502   ERBB2_HUMAN
MINT-74505   ERBB3_HUMAN
MINT-7103282   KCMA1_MOUSE
MINT-7103655   P85A_HUMAN
MINT-7103692   MK08_HUMAN
MINT-7137863   LYN_MOUSE
MINT-7235383   ABL1_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3/SH2 adaptor activity,
protein tyrosine kinase activity		 JNK cascade,
Ras protein signal transduction
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 207 SYGIPEPAHAYAQPQTTTPLP Abl 9710592
LTP
0.62
 CRKL SH2 -
0.67
 - low

Substrate: Disabled homolog 1 (Adapter molecule functioning in neural development)
Seq-ID: O75553 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-74508   ERBB2_HUMAN
MINT-74509   ERBB3_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 220 IRDPETEENIYQVPTSQKKEG - 15316068
LTP
0.93
 CRKL SH2 -
0.70
 - low
Y 232 VPTSQKKEGVYDVPKSQPVSN - 15316068
LTP
1.00
 CRKL SH2 -
0.56
 - low

Substrate: STAT 5 (Transcription factor)
Seq-ID: P42229 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-50646   ESR1_HUMAN
MINT-58264   STAP2_HUMAN
MINT-6793989   PTN1_HUMAN
MINT-7891339   EPOR_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
calcium ion binding,
sequence-specific DNA binding transcription factor activity,
protein binding		 cytoplasm,
nucleus		 valine metabolic process,
oxaloacetate metabolic process,
transcription,
creatinine metabolic process,
isoleucine metabolic process,
JAK-STAT cascade,
taurine metabolic process,
allantoin metabolic process,
fatty acid metabolic process,
citrate metabolic process,
2-oxoglutarate metabolic process,
succinate metabolic process,
creatine metabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 694 TPVLAKAVDGYVKPQIKQVVP Lyn 11641791
LTP
0.25
 CRKL SH2;
PTPN11 SH2;
STAT5 SH2		 SH2
0.20
 - medium
Y 694 TPVLAKAVDGYVKPQIKQVVP SRC 11641791
LTP
0.25
 CRKL SH2;
PTPN11 SH2;
STAT5 SH2		 SH2
0.20
 - medium
Y 694 TPVLAKAVDGYVKPQIKQVVP JAK2 11641791
LTP
0.25
 CRKL SH2;
PTPN11 SH2;
STAT5 SH2		 SH2
0.20
 - medium
Y 694 TPVLAKAVDGYVKPQIKQVVP - 17081983
HTP
0.25
 CRKL SH2;
PTPN11 SH2;
STAT5 SH2		 SH2
0.20
 - medium
Y 694 TPVLAKAVDGYVKPQIKQVVP - 18083107
HTP
0.25
 CRKL SH2;
PTPN11 SH2;
STAT5 SH2		 SH2
0.20
 - medium

Substrate: p62DOK (Docking protein, common target of PTKs)
Seq-ID: Q99704 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-74512   ERBB2_HUMAN
MINT-7974670   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
insulin receptor binding cytosol,
perinuclear region of cytoplasm		 transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 146 SALEMLENSLYSPTWEGSQFW - 11042170
LTP
1.00
 CRKL SH2 -
0.21
 --
Y 203 QILEPLLSWPYTLLRRYGRDK - 12087092
LTP
1.00
 CRKL SH2;
INPP5D SH2		 PTBI
0.17
 2V76 5.24%
Y 296 QELLDSPPALYAEPLDSLRIA - 12087092
LTP
0.05
 ABL1 SH2;
CRKL SH2;
RASA_group SH2		 -
0.48
 --
Y 296 QELLDSPPALYAEPLDSLRIA - 10688886
LTP
0.05
 ABL1 SH2;
CRKL SH2;
RASA_group SH2		 -
0.48
 --
Y 315 IAPCPSQDSLYSDPLDSTSAQ - 12087092
LTP
1.00
 ABL1 SH2;
CRKL SH2;
RASA_group SH2		 -
0.66
 --
Y 315 IAPCPSQDSLYSDPLDSTSAQ - 10688886
LTP
1.00
 ABL1 SH2;
CRKL SH2;
RASA_group SH2		 -
0.66
 --
Y 315 IAPCPSQDSLYSDPLDSTSAQ - 18083107
HTP
1.00
 ABL1 SH2;
CRKL SH2;
RASA_group SH2		 -
0.66
 --
Y 337 GEGVQRKKPLYWDLYEHAQQQ - 16497976
HTP
1.00
 CRKL SH2;
PTPN11 SH2		 -
0.48
 --
Y 341 QRKKPLYWDLYEHAQQQLLKA - 12087092
LTP
0.23
 CRKL SH2 -
0.41
 --
Y 362 KLTDPKEDPIYDEPEGLAPVP - 12087092
LTP
1.00
 ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2		 -
0.82
 --
Y 362 KLTDPKEDPIYDEPEGLAPVP INSR 11551902
LTP
1.00
 ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2		 -
0.82
 --
Y 362 KLTDPKEDPIYDEPEGLAPVP - 10688886
LTP
1.00
 ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2		 -
0.82
 --
Y 362 KLTDPKEDPIYDEPEGLAPVP - 15592455
HTP
1.00
 ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2		 -
0.82
 --
Y 362 KLTDPKEDPIYDEPEGLAPVP - 16094384
HTP
1.00
 ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2		 -
0.82
 --
Y 377 GLAPVPPQGLYDLPREPKDAW - 12087092
LTP
1.00
 ABL1 SH2;
CRKL SH2;
INPP5D SH2;
RASA_group SH2		 -
0.62
 --
Y 377 GLAPVPPQGLYDLPREPKDAW - 10688886
LTP
1.00
 ABL1 SH2;
CRKL SH2;
INPP5D SH2;
RASA_group SH2		 -
0.62
 --
Y 377 GLAPVPPQGLYDLPREPKDAW - 15592455
HTP
1.00
 ABL1 SH2;
CRKL SH2;
INPP5D SH2;
RASA_group SH2		 -
0.62
 --
Y 377 GLAPVPPQGLYDLPREPKDAW - 16094384
HTP
1.00
 ABL1 SH2;
CRKL SH2;
INPP5D SH2;
RASA_group SH2		 -
0.62
 --
Y 398 WCQARVKEEGYELPYNPATDD - 12087092
LTP
0.17
 ABL1 SH2;
CRKL SH2;
RASA_group SH2		 -
0.48
 --
Y 398 WCQARVKEEGYELPYNPATDD INSR 11551902
LTP
0.17
 ABL1 SH2;
CRKL SH2;
RASA_group SH2		 -
0.48
 --
Y 398 WCQARVKEEGYELPYNPATDD - 10688886
LTP
0.17
 ABL1 SH2;
CRKL SH2;
RASA_group SH2		 -
0.48
 --
Y 398 WCQARVKEEGYELPYNPATDD - 15592455
HTP
0.17
 ABL1 SH2;
CRKL SH2;
RASA_group SH2		 -
0.48
 --
Y 398 WCQARVKEEGYELPYNPATDD - 16094384
HTP
0.17
 ABL1 SH2;
CRKL SH2;
RASA_group SH2		 -
0.48
 --
Y 402 RVKEEGYELPYNPATDDYAVP - 15592455
HTP
1.00
 CRKL SH2 -
0.64
 --
Y 409 ELPYNPATDDYAVPPPRSTKP - 12087092
LTP
1.00
 ABL1 SH2;
CRKL SH2;
RASA_group SH2		 -
0.72
 --
Y 409 ELPYNPATDDYAVPPPRSTKP - 10688886
LTP
1.00
 ABL1 SH2;
CRKL SH2;
RASA_group SH2		 -
0.72
 --
Y 409 ELPYNPATDDYAVPPPRSTKP - 15592455
HTP
1.00
 ABL1 SH2;
CRKL SH2;
RASA_group SH2		 -
0.72
 --
Y 409 ELPYNPATDDYAVPPPRSTKP - 16094384
HTP
1.00
 ABL1 SH2;
CRKL SH2;
RASA_group SH2		 -
0.72
 --
Y 449 SGIKSHNSALYSQVQKSGASG - 12087092
LTP
0.00
 CRKL SH2;
SH2D1A SH2		 -
0.59
 --
Y 449 SGIKSHNSALYSQVQKSGASG - 10852966
LTP
0.00
 CRKL SH2;
SH2D1A SH2		 -
0.59
 --
Y 449 SGIKSHNSALYSQVQKSGASG - 12522270
HTP
0.00
 CRKL SH2;
SH2D1A SH2		 -
0.59
 --
Y 449 SGIKSHNSALYSQVQKSGASG - 15592455
HTP
0.00
 CRKL SH2;
SH2D1A SH2		 -
0.59
 --
Y 449 SGIKSHNSALYSQVQKSGASG - 16094384
HTP
0.00
 CRKL SH2;
SH2D1A SH2		 -
0.59
 --
Y 449 SGIKSHNSALYSQVQKSGASG - 15659558
HTP
0.00
 CRKL SH2;
SH2D1A SH2		 -
0.59
 --
Y 449 SGIKSHNSALYSQVQKSGASG - 18083107
HTP
0.00
 CRKL SH2;
SH2D1A SH2		 -
0.59
 --

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