List of substrates found:

EPHB3  VEGFR-1  PDGF-R alpha  ZAP70  CBL E3 ubiquitin protein ligase  P130Cas  Paxillin  EGFR  Gab1  IGF1-R  CAS-L  PDGF-R beta  EPHA3  Crk 


Substrate: EPHB3 (Receptor for member of the ephrinB family)
Seq-ID: P54753 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 614 GMKVYIDPFTYEDPNEAVREF EphB3 9674711
LTP
1.00
CRK SH2;
Fyn SH2;
RASA_group SH2
-
0.26
- low

Substrate: VEGFR-1 (Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity.)
Seq-ID: P17948 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1333 PPPDYNSVVLYSTPPI      FLT1 11513746
LTP
0.46
CRK SH2;
NCK SH2;
PLCG_group SH2
-
0.37
- low
Y 1333 PPPDYNSVVLYSTPPI      FLT1 9722576
LTP
0.46
CRK SH2;
NCK SH2;
PLCG_group SH2
-
0.37
- low
Y 1333 PPPDYNSVVLYSTPPI      - 9600074
LTP
0.46
CRK SH2;
NCK SH2;
PLCG_group SH2
-
0.37
- low

Substrate: PDGF-R alpha (Receptor tyrosine kinase)
Seq-ID: P16234 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 762 SKYSDIQRSLYDRPASYKKKS PDGFR_alpha 9546424
LTP
1.00
CRKL SH2;
CRK SH2
TyrKc
0.29
- medium
Y 762 SKYSDIQRSLYDRPASYKKKS - 18083107
HTP
1.00
CRKL SH2;
CRK SH2
TyrKc
0.29
- medium

Substrate: ZAP70 (Cytoplasmic tyrosine kinase)
Seq-ID: P43403 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 315 PRPMPMDTSVYESPYSDPEEL ZAP70 11828374
LTP
1.00
CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2
-
0.69
2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL ZAP70 7798261
LTP
1.00
CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2
-
0.69
2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL - 12522270
HTP
1.00
CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2
-
0.69
2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL - 15592455
HTP
1.00
CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2
-
0.69
2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL - 16094384
HTP
1.00
CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2
-
0.69
2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL ZAP70 10037717
LTP
1.00
CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2
-
0.69
2OZO 6.42%
Y 319 PMDTSVYESPYSDPEELKDKK - 10202147
LTP
1.00
CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2
-
0.52
2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 10318843
LTP
1.00
CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2
-
0.52
2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 12522270
HTP
1.00
CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2
-
0.52
2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 15592455
HTP
1.00
CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2
-
0.52
2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 16094384
HTP
1.00
CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2
-
0.52
2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 10037717
LTP
1.00
CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2
-
0.52
2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 15268851
LTP
1.00
CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2
-
0.52
2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 15292262
LTP
1.00
CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2
-
0.52
2OZO 1.83%

Substrate: CBL E3 ubiquitin protein ligase (Adaptor molecule)
Seq-ID: P22681 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 337 ALIDGFREGFYLFPDGRNQNP - 10608804
LTP
1.00
CRKL SH2;
CRK SH2;
PIK3R2 SH2
Cbl_N3
0.18
1YVH 9.61%
Y 700 EQCEGEEDTEYMTPSSRPLRP Fyn 9525940
LTP
0.63
CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2
-
0.85
--
Y 700 EQCEGEEDTEYMTPSSRPLRP SYK 9525940
LTP
0.63
CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2
-
0.85
--
Y 700 EQCEGEEDTEYMTPSSRPLRP Yes 9525940
LTP
0.63
CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2
-
0.85
--
Y 700 EQCEGEEDTEYMTPSSRPLRP - 9102067
LTP
0.63
CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2
-
0.85
--
Y 700 EQCEGEEDTEYMTPSSRPLRP - 12522270
HTP
0.63
CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2
-
0.85
--
Y 700 EQCEGEEDTEYMTPSSRPLRP INSR 11997497
LTP
0.63
CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2
-
0.85
--
Y 700 EQCEGEEDTEYMTPSSRPLRP - 10829062
LTP
0.63
CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2
-
0.85
--
Y 700 EQCEGEEDTEYMTPSSRPLRP - 15922744
LTP
0.63
CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2
-
0.85
--
Y 731 DCDQQIDSCTYEAMYNIQSQA Fyn 9525940
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 731 DCDQQIDSCTYEAMYNIQSQA SYK 9525940
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 731 DCDQQIDSCTYEAMYNIQSQA Yes 9525940
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 731 DCDQQIDSCTYEAMYNIQSQA - 10934191
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 731 DCDQQIDSCTYEAMYNIQSQA Fyn 9890970
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 731 DCDQQIDSCTYEAMYNIQSQA - 12604776
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 731 DCDQQIDSCTYEAMYNIQSQA - 15922744
LTP
0.29
CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2
-
0.47
--
Y 774 PEESENEDDGYDVPKPPVPAV Fyn 9525940
LTP
0.28
CRKL SH2;
CRK SH2;
PLCG1 SH2
-
0.89
--
Y 774 PEESENEDDGYDVPKPPVPAV SYK 9525940
LTP
0.28
CRKL SH2;
CRK SH2;
PLCG1 SH2
-
0.89
--
Y 774 PEESENEDDGYDVPKPPVPAV Yes 9525940
LTP
0.28
CRKL SH2;
CRK SH2;
PLCG1 SH2
-
0.89
--
Y 774 PEESENEDDGYDVPKPPVPAV - 12522270
HTP
0.28
CRKL SH2;
CRK SH2;
PLCG1 SH2
-
0.89
--
Y 774 PEESENEDDGYDVPKPPVPAV - 12604776
LTP
0.28
CRKL SH2;
CRK SH2;
PLCG1 SH2
-
0.89
--
Y 774 PEESENEDDGYDVPKPPVPAV - 10829062
LTP
0.28
CRKL SH2;
CRK SH2;
PLCG1 SH2
-
0.89
--
Y 774 PEESENEDDGYDVPKPPVPAV - 15922744
LTP
0.28
CRKL SH2;
CRK SH2;
PLCG1 SH2
-
0.89
--

Substrate: P130Cas (Adaptor molecule. Contain 15 YxxP motifs. )
Seq-ID: P56945 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 128 PTPSKAQQGLYQVPGPSPQFQ FGFR1 12601080
LTP
- CRKL SH2;
CRK SH2
-
0.76
- medium
Y 128 PTPSKAQQGLYQVPGPSPQFQ - 18083107
HTP
- CRKL SH2;
CRK SH2
-
0.76
- medium
Y 128 PTPSKAQQGLYQVPGPSPQFQ - 16212419
HTP
- CRKL SH2;
CRK SH2
-
0.76
- medium
Y 165 HPFPSPATDLYQVPPGPGGPA - 15817476
LTP
1.00
CRKL SH2;
CRK SH2
-
0.85
- medium
Y 234 YEAAQPEQDEYDIPRHLLAPG - 18083107
HTP
1.00
CRKL SH2;
CRK SH2
-
0.71
- medium
Y 234 YEAAQPEQDEYDIPRHLLAPG - 16212419
HTP
1.00
CRKL SH2;
CRK SH2
-
0.71
- medium
Y 249 HLLAPGPQDIYDVPPVRGLLP FGFR1 12601080
LTP
1.00
ABL1 SH2;
CRKL SH2;
CRK SH2
-
0.56
- medium
Y 249 HLLAPGPQDIYDVPPVRGLLP - 18083107
HTP
1.00
ABL1 SH2;
CRKL SH2;
CRK SH2
-
0.56
- medium
Y 249 HLLAPGPQDIYDVPPVRGLLP - 16212419
HTP
1.00
ABL1 SH2;
CRKL SH2;
CRK SH2
-
0.56
- medium
Y 306 GLPPSNHHAVYDVPPSVSKDV FGFR1 12601080
LTP
0.94
ABL1 SH2;
CRKL SH2;
CRK SH2
-
0.73
- medium
Y 327 PDGPLLREETYDVPPAFAKAK FGFR1 12601080
LTP
1.00
CRKL SH2;
CRK SH2
-
0.61
- medium
Y 387 GLRRPGPGTLYDVPRERVLPP - 15316024
LTP
0.02
CRKL SH2;
CRK SH2
-
0.73
- medium
Y 387 GLRRPGPGTLYDVPRERVLPP - 18083107
HTP
0.02
CRKL SH2;
CRK SH2
-
0.73
- medium
Y 387 GLRRPGPGTLYDVPRERVLPP - 16212419
HTP
0.02
CRKL SH2;
CRK SH2
-
0.73
- medium
Y 410 ADGGVVDSGVYAVPPPAEREA FGFR1 12601080
LTP
1.00
ABL1 SH2;
CRKL SH2;
CRK SH2
-
0.72
- medium

Substrate: Paxillin (Cytoskeletal protein; component of focal adhesion.)
Seq-ID: P49023 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 31 RPVFLSEETPYSYPTGNHTYQ FAK 7537852
LTP
1.00
CRKL SH2;
CRK SH2
-
0.57
- low
Y 31 RPVFLSEETPYSYPTGNHTYQ - 11774284
LTP
1.00
CRKL SH2;
CRK SH2
-
0.57
- low
Y 31 RPVFLSEETPYSYPTGNHTYQ - 10823820
LTP
1.00
CRKL SH2;
CRK SH2
-
0.57
- low
Y 31 RPVFLSEETPYSYPTGNHTYQ - 15107421
LTP
1.00
CRKL SH2;
CRK SH2
-
0.57
- low
Y 31 RPVFLSEETPYSYPTGNHTYQ - 16254239
HTP
1.00
CRKL SH2;
CRK SH2
-
0.57
- low
Y 31 RPVFLSEETPYSYPTGNHTYQ - 15817476
LTP
1.00
CRKL SH2;
CRK SH2
-
0.57
- low
Y 31 RPVFLSEETPYSYPTGNHTYQ Brk 15572663
LTP
1.00
CRKL SH2;
CRK SH2
-
0.57
- low
Y 31 RPVFLSEETPYSYPTGNHTYQ FAK 12408869
LTP
1.00
CRKL SH2;
CRK SH2
-
0.57
- low
Y 40 PYSYPTGNHTYQEIAVPPPVP SRC 11695992
LTP
0.93
CRK SH2;
Src SH2
-
0.77
- low
Y 40 PYSYPTGNHTYQEIAVPPPVP - 16254239
HTP
0.93
CRK SH2;
Src SH2
-
0.77
- low
Y 118 CSRVGEEEHVYSFPNKQKSAE FAK 7537852
LTP
0.93
CRKL SH2;
CRK SH2;
Csk SH2
Paxillin
0.73
- low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 11774284
LTP
0.93
CRKL SH2;
CRK SH2;
Csk SH2
Paxillin
0.73
- low
Y 118 CSRVGEEEHVYSFPNKQKSAE FAK 7615549
LTP
0.93
CRKL SH2;
CRK SH2;
Csk SH2
Paxillin
0.73
- low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 15592455
HTP
0.93
CRKL SH2;
CRK SH2;
Csk SH2
Paxillin
0.73
- low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 15107421
LTP
0.93
CRKL SH2;
CRK SH2;
Csk SH2
Paxillin
0.73
- low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 16254239
HTP
0.93
CRKL SH2;
CRK SH2;
Csk SH2
Paxillin
0.73
- low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 16094384
HTP
0.93
CRKL SH2;
CRK SH2;
Csk SH2
Paxillin
0.73
- low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 15817476
LTP
0.93
CRKL SH2;
CRK SH2;
Csk SH2
Paxillin
0.73
- low
Y 118 CSRVGEEEHVYSFPNKQKSAE Brk 15572663
LTP
0.93
CRKL SH2;
CRK SH2;
Csk SH2
Paxillin
0.73
- low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 18083107
HTP
0.93
CRKL SH2;
CRK SH2;
Csk SH2
Paxillin
0.73
- low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 18669648
HTP
0.93
CRKL SH2;
CRK SH2;
Csk SH2
Paxillin
0.73
- low
Y 181 PPLPGALSPLYGVPETNSPLG - 11774284
LTP
1.00
CRK SH2 Paxillin
0.77
- low
Y 181 PPLPGALSPLYGVPETNSPLG - 16254239
HTP
1.00
CRK SH2 Paxillin
0.77
- low

Substrate: EGFR (Receptor for EGF and other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor,)
Seq-ID: P00533 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1016 DMDDVVDADEYLIPQQGFFSS SRC 8845374
LTP
1.00
CRK SH2;
PLCG1 SH2;
RASA_group SH2;
Src SH2
-
0.41
1XKK 41.92%
Y 1016 DMDDVVDADEYLIPQQGFFSS - 7680558
LTP
1.00
CRK SH2;
PLCG1 SH2;
RASA_group SH2;
Src SH2
-
0.41
1XKK 41.92%
Y 1016 DMDDVVDADEYLIPQQGFFSS - 15302935
HTP
1.00
CRK SH2;
PLCG1 SH2;
RASA_group SH2;
Src SH2
-
0.41
1XKK 41.92%

Substrate: Gab1 (Multisubstrate docking protein downstream in the signaling pathways of different RTK.)
Seq-ID: Q13480 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 242 MNGFFQQQMIYDSPPSRAPSA INSR 10978177
LTP
1.00
CRKL SH2;
CRK SH2;
NCK SH2
-
0.65
- low
Y 259 APSASVDSSLYNLPRSYSHDV - 12522270
HTP
0.15
CRKL SH2;
CRK SH2
-
0.59
- low
Y 307 ETQMRHVSISYDIPPTPGNTY Met 10734310
LTP
0.12
CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2
-
0.70
- low
Y 307 ETQMRHVSISYDIPPTPGNTY EGFR 10734310
LTP
0.12
CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2
-
0.70
- low
Y 317 YDIPPTPGNTYQIPRTFPEGT - 16497976
HTP
0.24
CRKL SH2;
CRK SH2;
PLCG1 SH2;
RASA_group SH2
-
0.74
- low
Y 373 PRTASDTDSSYCIPTAGMSPS INSR 10978177
LTP
0.08
CRKL SH2;
CRK SH2;
PLCG1 SH2
-
0.66
- low
Y 373 PRTASDTDSSYCIPTAGMSPS EGFR 9890893
LTP
0.08
CRKL SH2;
CRK SH2;
PLCG1 SH2
-
0.66
- low
Y 373 PRTASDTDSSYCIPTAGMSPS - 10753869
LTP
0.08
CRKL SH2;
CRK SH2;
PLCG1 SH2
-
0.66
- low
Y 373 PRTASDTDSSYCIPTAGMSPS Met 10734310
LTP
0.08
CRKL SH2;
CRK SH2;
PLCG1 SH2
-
0.66
- low
Y 406 LRKDASSQDCYDIPRAFPSDR EGFR 9890893
LTP
1.00
CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2;
SHC_group SH2
-
0.61
- low
Y 406 LRKDASSQDCYDIPRAFPSDR - 10753869
LTP
1.00
CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2;
SHC_group SH2
-
0.61
- low
Y 406 LRKDASSQDCYDIPRAFPSDR Met 10734310
LTP
1.00
CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2;
SHC_group SH2
-
0.61
- low
Y 406 LRKDASSQDCYDIPRAFPSDR - 18083107
HTP
1.00
CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2;
SHC_group SH2
-
0.61
- low

Substrate: IGF1-R (Receptor tyrosine kinase)
Seq-ID: P08069 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 973 NNSRLGNGVLYASVNPEYFSA IGF1R 8550552
LTP
1.00
CRK SH2;
Csk SH2
-
0.16
--
Y 973 NNSRLGNGVLYASVNPEYFSA IGF1R 8940173
LTP
1.00
CRK SH2;
Csk SH2
-
0.16
--
Y 980 GVLYASVNPEYFSAADVYVPD IGF1R 8550552
LTP
1.00
CRK SH2;
IRS1 PTB;
RASA_group SH2;
SHC PTB
-
0.07
1P4O 89.96%
Y 980 GVLYASVNPEYFSAADVYVPD IGF1R 8940173
LTP
1.00
CRK SH2;
IRS1 PTB;
RASA_group SH2;
SHC PTB
-
0.07
1P4O 89.96%
Y 980 GVLYASVNPEYFSAADVYVPD - 7537849
LTP
1.00
CRK SH2;
IRS1 PTB;
RASA_group SH2;
SHC PTB
-
0.07
1P4O 89.96%
Y 980 GVLYASVNPEYFSAADVYVPD - 7559478
LTP
1.00
CRK SH2;
IRS1 PTB;
RASA_group SH2;
SHC PTB
-
0.07
1P4O 89.96%

Substrate: CAS-L (Docking protein)
Seq-ID: Q14511 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 166 TPVRTGHGYVYEYPSRYQKDV - 12522270
HTP
1.00
ABL1 SH2;
CRKL SH2;
CRK SH2;
NCK SH2
-
0.43
- medium
Y 317 GQSVGSQNDAYDVPRGVQFLE - 18083107
HTP
1.00
ABL1 SH2;
CRKL SH2;
CRK SH2;
NCK SH2
-
0.70
- medium
Y 345 KANPQERDGVYDVPLHNPPDA - 18083107
HTP
1.00
ABL1 SH2;
CRKL SH2;
CRK SH2;
NCK SH2
-
0.86
- medium

Substrate: PDGF-R beta (Beta platelet-derived growth factor receptor)
Seq-ID: P09619 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 771 VKYADIESSNYMAPYDNYVPS PDGFR_beta 8195171
LTP
1.00
CRK SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2
TyrKc
0.25
- medium

Substrate: EPHA3 (Receptor for member of the ephrinA family)
Seq-ID: P29320 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
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Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 596 GHLKLPGLRTYVDPHTYEDPT - 11870224
LTP
1.00
CRK SH2 -
0.38
2QO7 13.54%
Y 596 GHLKLPGLRTYVDPHTYEDPT - 8622983
LTP
1.00
CRK SH2 -
0.38
2QO7 13.54%
Y 602 GLRTYVDPHTYEDPTQAVHEF EphA3 11870224
LTP
1.00
CRK SH2 -
0.39
2QOD 13.97%

Substrate: Crk (The Crk protein contains a single SH2 and two SH3 domains in the order SH2-SH3-SH3)
Seq-ID: P46108 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-15716   CBL_HUMAN
MINT-17467   VAV_HUMAN
MINT-51245   SMAD3_HUMAN
MINT-72620   WASL_HUMAN
MINT-74497   EGFR_HUMAN
MINT-74498   ERBB2_HUMAN
MINT-74500   ERBB3_HUMAN
MINT-2855127   ATX1_HUMAN
MINT-6762904   IRS1_RAT
MINT-6763928   PAXI_HUMAN
MINT-6763936   BCAR1_HUMAN
MINT-7103547   MK08_HUMAN
MINT-7104372   ACK1_HUMAN
MINT-7235318   ABL1_MOUSE
MINT-7253878   SNX17_HUMAN
MINT-7253890   PHAR2_HUMAN
MINT-7253902   FANCA_HUMAN
MINT-7253974   AKAP6_HUMAN
MINT-7254022   MINT_HUMAN
MINT-7254046   AKAP2_HUMAN
MINT-7254082   ICAL_HUMAN
MINT-7254106   ABL1_HUMAN
MINT-7254130   ASAP2_HUMAN
MINT-7254142   FCG2B_HUMAN
MINT-7254154   FCG2C_HUMAN
MINT-7254202   ASAP1_HUMAN
MINT-7254250   DOCK1_HUMAN
MINT-7254262   RRAS_HUMAN
MINT-7254274   SOS1_HUMAN
MINT-7254286   RGS7_HUMAN
MINT-7254334   E41L3_HUMAN
MINT-7254406   DNLI3_HUMAN
MINT-7254430   RPGF1_HUMAN
MINT-7254454   DLGP4_HUMAN
MINT-7254478   SP1_HUMAN
MINT-7254490   FLNB_HUMAN
MINT-7254502   TGON2_HUMAN
MINT-7254514   C1QR1_HUMAN
MINT-7254526   GHR_HUMAN
MINT-7254538   SHAN2_HUMAN
MINT-7254550   SUV92_HUMAN
MINT-7254562   CELR2_HUMAN
MINT-7254574   ABL2_HUMAN
MINT-7254586   THOC2_HUMAN
MINT-7254634   ASPP2_HUMAN
MINT-7254658   TPX2_HUMAN
MINT-7254694   NFASC_HUMAN
MINT-7254706   STF1_HUMAN
MINT-7254718   FLNC_HUMAN
MINT-7254754   DDX41_HUMAN
MINT-7254766   MLL4_HUMAN
MINT-7254780   TRI39_HUMAN
MINT-7254804   M4K1_HUMAN
MINT-7254852   TAL1_HUMAN
MINT-7254864   ARHGB_HUMAN
MINT-7254876   FLNA_HUMAN
MINT-7254936   KIF22_HUMAN
MINT-7254948   BMX_HUMAN
MINT-7254960   DYN2_HUMAN
MINT-7254999   MY18B_HUMAN
MINT-7255074   RPP38_HUMAN
MINT-7255086   SNX3_HUMAN
MINT-7255245   PRIC3_HUMAN
MINT-7255257   BRD4_HUMAN
MINT-7255293   GCF_HUMAN
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 221 QPLGGPEPGPYAQPSVNTPLP - 12198159
LTP
0.31
CRK SH2 -
0.84
--
Y 221 QPLGGPEPGPYAQPSVNTPLP - 9642287
LTP
0.31
CRK SH2 -
0.84
--
Y 221 QPLGGPEPGPYAQPSVNTPLP - 9480991
LTP
0.31
CRK SH2 -
0.84
--
Y 221 QPLGGPEPGPYAQPSVNTPLP Abl 8194526
LTP
0.31
CRK SH2 -
0.84
--


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