List of substrates found:

EPHB3  VEGFR-1  PDGF-R alpha  ZAP70  CBL E3 ubiquitin protein ligase  P130Cas  Paxillin  EGFR  Gab1  IGF1-R  CAS-L  PDGF-R beta  EPHA3  Crk 


Substrate: EPHB3 (Receptor for member of the ephrinB family)
Seq-ID: P54753 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-58214   AFAD_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
ephrin receptor activity,
ATP binding,
protein binding		 integral to plasma membrane protein amino acid phosphorylation,
transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 614 GMKVYIDPFTYEDPNEAVREF EphB3 9674711
LTP
1.00
 CRK SH2;
Fyn SH2;
RASA_group SH2		 -
0.26
 - low

Substrate: VEGFR-1 (Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity.)
Seq-ID: P17948 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-6177086   LDLR_HUMAN
MINT-6539646   CBL_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
vascular endothelial growth factor receptor activity,
ATP binding,
growth factor binding		 cytoplasm,
integral to plasma membrane,
extracellular space		 positive regulation of vascular endothelial growth factor receptor signaling pathway,
female pregnancy,
peptidyl-tyrosine phosphorylation,
cell differentiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1333 PPPDYNSVVLYSTPPI      FLT1 11513746
LTP
0.46
 CRK SH2;
NCK SH2;
PLCG_group SH2		 -
0.37
 - low
Y 1333 PPPDYNSVVLYSTPPI      FLT1 9722576
LTP
0.46
 CRK SH2;
NCK SH2;
PLCG_group SH2		 -
0.37
 - low
Y 1333 PPPDYNSVVLYSTPPI      - 9600074
LTP
0.46
 CRK SH2;
NCK SH2;
PLCG_group SH2		 -
0.37
 - low

Substrate: PDGF-R alpha (Receptor tyrosine kinase)
Seq-ID: P16234 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
platelet-derived growth factor alpha-receptor activity,
vascular endothelial growth factor receptor activity,
platelet-derived growth factor binding,
protein homodimerization activity,
platelet-derived growth factor receptor binding,
ATP binding		 integral to plasma membrane positive regulation of DNA replication,
positive regulation of fibroblast proliferation,
cell activation,
positive regulation of cell migration,
protein amino acid autophosphorylation,
peptidyl-tyrosine phosphorylation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 762 SKYSDIQRSLYDRPASYKKKS PDGFR_alpha 9546424
LTP
1.00
 CRKL SH2;
CRK SH2		 TyrKc
0.29
 - medium
Y 762 SKYSDIQRSLYDRPASYKKKS - 18083107
HTP
1.00
 CRKL SH2;
CRK SH2		 TyrKc
0.29
 - medium

Substrate: ZAP70 (Cytoplasmic tyrosine kinase)
Seq-ID: P43403 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-59476   LCK_HUMAN
MINT-60980   SHC1_HUMAN
MINT-74806   ERBB3_HUMAN
MINT-74807   EGFR_HUMAN
MINT-3374106   HS90A_HUMAN
MINT-3382488   LAT_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
non-membrane spanning protein tyrosine kinase activity,
ATP binding		 cytosol,
T cell receptor complex		 positive thymic T cell selection,
immune response,
intracellular protein kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 315 PRPMPMDTSVYESPYSDPEEL ZAP70 11828374
LTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL ZAP70 7798261
LTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL - 12522270
HTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL - 15592455
HTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL - 16094384
HTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL ZAP70 10037717
LTP
1.00
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2		 -
0.69
 2OZO 6.42%
Y 319 PMDTSVYESPYSDPEELKDKK - 10202147
LTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 10318843
LTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 12522270
HTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 15592455
HTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 16094384
HTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 10037717
LTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 15268851
LTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 15292262
LTP
1.00
 CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2		 -
0.52
 2OZO 1.83%

Substrate: CBL E3 ubiquitin protein ligase (Adaptor molecule)
Seq-ID: P22681 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-15516   LCK_HUMAN
MINT-15716   CRK_HUMAN
MINT-16022   CD2AP_HUMAN
MINT-16347   LYN_HUMAN
MINT-16846   LCP2_HUMAN
MINT-17062   FCGR1_HUMAN
MINT-17932   NCK1_HUMAN
MINT-50666   FYN_HUMAN
MINT-50717   ABL1_HUMAN
MINT-50722   CRKL_HUMAN
MINT-58331   ITCH_HUMAN
MINT-60970   RET_HUMAN
MINT-60973   EGFR_HUMAN
MINT-60978   SHC1_HUMAN
MINT-68500   P85A_HUMAN
MINT-2837344   PLCG1_BOVIN
MINT-4299918   ASAP1_HUMAN
MINT-6169713   SPY1_HUMAN
MINT-6170244   SH3G2_HUMAN
MINT-6538940   SPY4_HUMAN
MINT-6538977   KSYK_HUMAN
MINT-6539587   MET_HUMAN
MINT-6539601   SPY2_HUMAN
MINT-6539646   VGFR1_HUMAN
MINT-6539679   RON_HUMAN
MINT-6539730   SRC_HUMAN
MINT-7040249   GRB2_HUMAN
MINT-7046364   ITSN1_HUMAN
MINT-7103623   MK08_HUMAN
MINT-7211864   ARHG7_HUMAN
MINT-7214822   FYN_MOUSE
MINT-7218352   SH3K1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
calcium ion binding,
zinc ion binding,
sequence-specific DNA binding transcription factor activity,
signal transducer activity,
ubiquitin-protein ligase activity		 cytosol,
nucleus		 epidermal growth factor receptor signaling pathway,
positive regulation of receptor-mediated endocytosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 337 ALIDGFREGFYLFPDGRNQNP - 10608804
LTP
1.00
 CRKL SH2;
CRK SH2;
PIK3R2 SH2		 Cbl_N3
0.18
 1YVH 9.61%
Y 700 EQCEGEEDTEYMTPSSRPLRP Fyn 9525940
LTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 700 EQCEGEEDTEYMTPSSRPLRP SYK 9525940
LTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 700 EQCEGEEDTEYMTPSSRPLRP Yes 9525940
LTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 700 EQCEGEEDTEYMTPSSRPLRP - 9102067
LTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 700 EQCEGEEDTEYMTPSSRPLRP - 12522270
HTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 700 EQCEGEEDTEYMTPSSRPLRP INSR 11997497
LTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 700 EQCEGEEDTEYMTPSSRPLRP - 10829062
LTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 700 EQCEGEEDTEYMTPSSRPLRP - 15922744
LTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 731 DCDQQIDSCTYEAMYNIQSQA Fyn 9525940
LTP
0.29
 CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2		 -
0.47
 --
Y 731 DCDQQIDSCTYEAMYNIQSQA SYK 9525940
LTP
0.29
 CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2		 -
0.47
 --
Y 731 DCDQQIDSCTYEAMYNIQSQA Yes 9525940
LTP
0.29
 CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2		 -
0.47
 --
Y 731 DCDQQIDSCTYEAMYNIQSQA - 10934191
LTP
0.29
 CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2		 -
0.47
 --
Y 731 DCDQQIDSCTYEAMYNIQSQA Fyn 9890970
LTP
0.29
 CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2		 -
0.47
 --
Y 731 DCDQQIDSCTYEAMYNIQSQA - 12604776
LTP
0.29
 CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2		 -
0.47
 --
Y 731 DCDQQIDSCTYEAMYNIQSQA - 15922744
LTP
0.29
 CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2		 -
0.47
 --
Y 774 PEESENEDDGYDVPKPPVPAV Fyn 9525940
LTP
0.28
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.89
 --
Y 774 PEESENEDDGYDVPKPPVPAV SYK 9525940
LTP
0.28
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.89
 --
Y 774 PEESENEDDGYDVPKPPVPAV Yes 9525940
LTP
0.28
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.89
 --
Y 774 PEESENEDDGYDVPKPPVPAV - 12522270
HTP
0.28
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.89
 --
Y 774 PEESENEDDGYDVPKPPVPAV - 12604776
LTP
0.28
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.89
 --
Y 774 PEESENEDDGYDVPKPPVPAV - 10829062
LTP
0.28
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.89
 --
Y 774 PEESENEDDGYDVPKPPVPAV - 15922744
LTP
0.28
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.89
 --

Substrate: P130Cas (Adaptor molecule. Contain 15 YxxP motifs. )
Seq-ID: P56945 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-74936   PTN12_HUMAN
MINT-74938   FAK1_HUMAN
MINT-3974941   1433S_HUMAN
MINT-6174734   ACTB_HUMAN
MINT-6763936   CRK_HUMAN
MINT-6793484   PTN1_HUMAN
MINT-7104353   CDC42_HUMAN
MINT-7104422   SRC_HUMAN
MINT-7104436   ACK1_HUMAN
MINT-7247002   FYN_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
protein kinase binding,
protein phosphatase binding,
signal transducer activity		 focal adhesion,
membrane fraction,
cytosol,
ruffle		 regulation of cell growth,
B cell receptor signaling pathway,
cell division,
positive regulation of cell migration,
nerve growth factor receptor signaling pathway,
cell migration,
integrin-mediated signaling pathway,
epidermal growth factor receptor signaling pathway,
actin filament organization,
regulation of apoptosis,
platelet-derived growth factor receptor signaling pathway,
T cell receptor signaling pathway,
cell adhesion,
insulin receptor signaling pathway,
cell proliferation,
G-protein coupled receptor protein signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 128 PTPSKAQQGLYQVPGPSPQFQ FGFR1 12601080
LTP
 - CRKL SH2;
CRK SH2		 -
0.76
 - medium
Y 128 PTPSKAQQGLYQVPGPSPQFQ - 18083107
HTP
 - CRKL SH2;
CRK SH2		 -
0.76
 - medium
Y 128 PTPSKAQQGLYQVPGPSPQFQ - 16212419
HTP
 - CRKL SH2;
CRK SH2		 -
0.76
 - medium
Y 165 HPFPSPATDLYQVPPGPGGPA - 15817476
LTP
1.00
 CRKL SH2;
CRK SH2		 -
0.85
 - medium
Y 234 YEAAQPEQDEYDIPRHLLAPG - 18083107
HTP
1.00
 CRKL SH2;
CRK SH2		 -
0.71
 - medium
Y 234 YEAAQPEQDEYDIPRHLLAPG - 16212419
HTP
1.00
 CRKL SH2;
CRK SH2		 -
0.71
 - medium
Y 249 HLLAPGPQDIYDVPPVRGLLP FGFR1 12601080
LTP
1.00
 ABL1 SH2;
CRKL SH2;
CRK SH2		 -
0.56
 - medium
Y 249 HLLAPGPQDIYDVPPVRGLLP - 18083107
HTP
1.00
 ABL1 SH2;
CRKL SH2;
CRK SH2		 -
0.56
 - medium
Y 249 HLLAPGPQDIYDVPPVRGLLP - 16212419
HTP
1.00
 ABL1 SH2;
CRKL SH2;
CRK SH2		 -
0.56
 - medium
Y 306 GLPPSNHHAVYDVPPSVSKDV FGFR1 12601080
LTP
0.94
 ABL1 SH2;
CRKL SH2;
CRK SH2		 -
0.73
 - medium
Y 327 PDGPLLREETYDVPPAFAKAK FGFR1 12601080
LTP
1.00
 CRKL SH2;
CRK SH2		 -
0.61
 - medium
Y 387 GLRRPGPGTLYDVPRERVLPP - 15316024
LTP
0.02
 CRKL SH2;
CRK SH2		 -
0.73
 - medium
Y 387 GLRRPGPGTLYDVPRERVLPP - 18083107
HTP
0.02
 CRKL SH2;
CRK SH2		 -
0.73
 - medium
Y 387 GLRRPGPGTLYDVPRERVLPP - 16212419
HTP
0.02
 CRKL SH2;
CRK SH2		 -
0.73
 - medium
Y 410 ADGGVVDSGVYAVPPPAEREA FGFR1 12601080
LTP
1.00
 ABL1 SH2;
CRKL SH2;
CRK SH2		 -
0.72
 - medium

Substrate: Paxillin (Cytoskeletal protein; component of focal adhesion.)
Seq-ID: P49023 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-1953339   GIT1_HUMAN
MINT-1953360   GIT2_HUMAN
MINT-6169431   CSK_HUMAN
MINT-6169440   PTN11_HUMAN
MINT-6169502   GAB1_HUMAN
MINT-6763928   CRK_HUMAN
MINT-7145479   ASAP1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
beta-catenin binding,
vinculin binding,
zinc ion binding		 focal adhesion,
cytoplasm,
microtubule associated complex,
lamellipodium		 muscle contraction,
signal complex assembly,
signal transduction,
cell-matrix adhesion,
cellular response to reactive oxygen species
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 31 RPVFLSEETPYSYPTGNHTYQ FAK 7537852
LTP
1.00
 CRKL SH2;
CRK SH2		 -
0.57
 - low
Y 31 RPVFLSEETPYSYPTGNHTYQ - 11774284
LTP
1.00
 CRKL SH2;
CRK SH2		 -
0.57
 - low
Y 31 RPVFLSEETPYSYPTGNHTYQ - 10823820
LTP
1.00
 CRKL SH2;
CRK SH2		 -
0.57
 - low
Y 31 RPVFLSEETPYSYPTGNHTYQ - 15107421
LTP
1.00
 CRKL SH2;
CRK SH2		 -
0.57
 - low
Y 31 RPVFLSEETPYSYPTGNHTYQ - 16254239
HTP
1.00
 CRKL SH2;
CRK SH2		 -
0.57
 - low
Y 31 RPVFLSEETPYSYPTGNHTYQ - 15817476
LTP
1.00
 CRKL SH2;
CRK SH2		 -
0.57
 - low
Y 31 RPVFLSEETPYSYPTGNHTYQ Brk 15572663
LTP
1.00
 CRKL SH2;
CRK SH2		 -
0.57
 - low
Y 31 RPVFLSEETPYSYPTGNHTYQ FAK 12408869
LTP
1.00
 CRKL SH2;
CRK SH2		 -
0.57
 - low
Y 40 PYSYPTGNHTYQEIAVPPPVP SRC 11695992
LTP
0.93
 CRK SH2;
Src SH2		 -
0.77
 - low
Y 40 PYSYPTGNHTYQEIAVPPPVP - 16254239
HTP
0.93
 CRK SH2;
Src SH2		 -
0.77
 - low
Y 118 CSRVGEEEHVYSFPNKQKSAE FAK 7537852
LTP
0.93
 CRKL SH2;
CRK SH2;
Csk SH2		 Paxillin
0.73
 - low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 11774284
LTP
0.93
 CRKL SH2;
CRK SH2;
Csk SH2		 Paxillin
0.73
 - low
Y 118 CSRVGEEEHVYSFPNKQKSAE FAK 7615549
LTP
0.93
 CRKL SH2;
CRK SH2;
Csk SH2		 Paxillin
0.73
 - low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 15592455
HTP
0.93
 CRKL SH2;
CRK SH2;
Csk SH2		 Paxillin
0.73
 - low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 15107421
LTP
0.93
 CRKL SH2;
CRK SH2;
Csk SH2		 Paxillin
0.73
 - low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 16254239
HTP
0.93
 CRKL SH2;
CRK SH2;
Csk SH2		 Paxillin
0.73
 - low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 16094384
HTP
0.93
 CRKL SH2;
CRK SH2;
Csk SH2		 Paxillin
0.73
 - low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 15817476
LTP
0.93
 CRKL SH2;
CRK SH2;
Csk SH2		 Paxillin
0.73
 - low
Y 118 CSRVGEEEHVYSFPNKQKSAE Brk 15572663
LTP
0.93
 CRKL SH2;
CRK SH2;
Csk SH2		 Paxillin
0.73
 - low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 18083107
HTP
0.93
 CRKL SH2;
CRK SH2;
Csk SH2		 Paxillin
0.73
 - low
Y 118 CSRVGEEEHVYSFPNKQKSAE - 18669648
HTP
0.93
 CRKL SH2;
CRK SH2;
Csk SH2		 Paxillin
0.73
 - low
Y 181 PPLPGALSPLYGVPETNSPLG - 11774284
LTP
1.00
 CRK SH2 Paxillin
0.77
 - low
Y 181 PPLPGALSPLYGVPETNSPLG - 16254239
HTP
1.00
 CRK SH2 Paxillin
0.77
 - low

Substrate: EGFR (Receptor for EGF and other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor,)
Seq-ID: P00533 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16802   GRB10_HUMAN
MINT-50935   1433Z_HUMAN
MINT-51101   ANXA1_HUMAN
MINT-51490   ARBK1_HUMAN
MINT-60973   CBL_HUMAN
MINT-61486   CRKL_HUMAN
MINT-61487   CSK_HUMAN
MINT-61490   STA5B_HUMAN
MINT-61540   GRB2_HUMAN
MINT-68514   PDC6I_HUMAN
MINT-74427   ABL1_HUMAN
MINT-74438   ABL2_HUMAN
MINT-74460   ANS1A_HUMAN
MINT-74469   APBB1_HUMAN
MINT-74479   DP13A_HUMAN
MINT-74487   BMX_HUMAN
MINT-74497   CRK_HUMAN
MINT-74535   FES_HUMAN
MINT-74551   IRS1_HUMAN
MINT-74555   IRS4_HUMAN
MINT-74562   JAK2_HUMAN
MINT-74566   SH2B3_HUMAN
MINT-74572   JIP1_HUMAN
MINT-74587   NCK1_HUMAN
MINT-74593   NUMB_HUMAN
MINT-74594   NUMBL_HUMAN
MINT-74606   P85A_HUMAN
MINT-74630   P85B_HUMAN
MINT-74659   P55G_HUMAN
MINT-74678   PLCG1_HUMAN
MINT-74685   PLCG2_HUMAN
MINT-74687   PTK6_HUMAN
MINT-74689   PTN11_HUMAN
MINT-74711   RASA1_HUMAN
MINT-74717   SH2B1_HUMAN
MINT-74720   SH22A_HUMAN
MINT-74732   SHC1_HUMAN
MINT-74746   SLAP1_HUMAN
MINT-74763   KSYK_HUMAN
MINT-74790   TLN1_HUMAN
MINT-74807   ZAP70_HUMAN
MINT-1788719   ERBB2_HUMAN
MINT-6169667   ESR1_HUMAN
MINT-6170031   SOS1_MOUSE
MINT-6170198   SH3G2_HUMAN
MINT-6170268   SH3K1_HUMAN
MINT-6793358   PTN1_HUMAN
MINT-7980526   TM1L1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
epidermal growth factor receptor activity,
protein heterodimerization activity,
identical protein binding,
receptor signaling protein tyrosine kinase activity,
double-stranded DNA binding,
ATP binding,
protein phosphatase binding,
actin filament binding,
MAP/ERK kinase kinase activity		 Shc-EGFR complex,
endosome,
basolateral plasma membrane,
integral to membrane,
extracellular space,
nucleus		 activation of phospholipase C activity,
protein insertion into membrane,
response to UV-A,
positive regulation of nitric oxide biosynthetic process,
positive regulation of cell migration,
positive regulation of cyclin-dependent protein kinase activity involved in G1/S,
positive regulation of catenin protein nuclear translocation,
regulation of nitric-oxide synthase activity,
positive regulation of protein kinase B signaling cascade,
ossification,
positive regulation of epithelial cell proliferation,
activation of phospholipase A2 activity by calcium-mediated signaling,
cell-cell adhesion,
regulation of peptidyl-tyrosine phosphorylation,
positive regulation of phosphorylation,
positive regulation of MAP kinase activity,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1016 DMDDVVDADEYLIPQQGFFSS SRC 8845374
LTP
1.00
 CRK SH2;
PLCG1 SH2;
RASA_group SH2;
Src SH2		 -
0.41
 1XKK 41.92%
Y 1016 DMDDVVDADEYLIPQQGFFSS - 7680558
LTP
1.00
 CRK SH2;
PLCG1 SH2;
RASA_group SH2;
Src SH2		 -
0.41
 1XKK 41.92%
Y 1016 DMDDVVDADEYLIPQQGFFSS - 15302935
HTP
1.00
 CRK SH2;
PLCG1 SH2;
RASA_group SH2;
Src SH2		 -
0.41
 1XKK 41.92%

Substrate: Gab1 (Multisubstrate docking protein downstream in the signaling pathways of different RTK.)
Seq-ID: Q13480 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-58395   GRB2_HUMAN
MINT-58403   GRAP2_HUMAN
MINT-58404   MET_HUMAN
MINT-68564   BMX_HUMAN
MINT-1893011   P85A_HUMAN
MINT-6169406   PTN11_HUMAN
MINT-6169502   PAXI_HUMAN
MINT-7971128   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3/SH2 adaptor activity cytosol epidermal growth factor receptor signaling pathway,
insulin receptor signaling pathway,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 242 MNGFFQQQMIYDSPPSRAPSA INSR 10978177
LTP
1.00
 CRKL SH2;
CRK SH2;
NCK SH2		 -
0.65
 - low
Y 259 APSASVDSSLYNLPRSYSHDV - 12522270
HTP
0.15
 CRKL SH2;
CRK SH2		 -
0.59
 - low
Y 307 ETQMRHVSISYDIPPTPGNTY Met 10734310
LTP
0.12
 CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2		 -
0.70
 - low
Y 307 ETQMRHVSISYDIPPTPGNTY EGFR 10734310
LTP
0.12
 CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2		 -
0.70
 - low
Y 317 YDIPPTPGNTYQIPRTFPEGT - 16497976
HTP
0.24
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
RASA_group SH2		 -
0.74
 - low
Y 373 PRTASDTDSSYCIPTAGMSPS INSR 10978177
LTP
0.08
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.66
 - low
Y 373 PRTASDTDSSYCIPTAGMSPS EGFR 9890893
LTP
0.08
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.66
 - low
Y 373 PRTASDTDSSYCIPTAGMSPS - 10753869
LTP
0.08
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.66
 - low
Y 373 PRTASDTDSSYCIPTAGMSPS Met 10734310
LTP
0.08
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.66
 - low
Y 406 LRKDASSQDCYDIPRAFPSDR EGFR 9890893
LTP
1.00
 CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2;
SHC_group SH2		 -
0.61
 - low
Y 406 LRKDASSQDCYDIPRAFPSDR - 10753869
LTP
1.00
 CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2;
SHC_group SH2		 -
0.61
 - low
Y 406 LRKDASSQDCYDIPRAFPSDR Met 10734310
LTP
1.00
 CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2;
SHC_group SH2		 -
0.61
 - low
Y 406 LRKDASSQDCYDIPRAFPSDR - 18083107
HTP
1.00
 CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2;
SHC_group SH2		 -
0.61
 - low

Substrate: IGF1-R (Receptor tyrosine kinase)
Seq-ID: P08069 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-15644   GRB10_HUMAN
MINT-18053   IRS2_HUMAN
MINT-1774754   ARHGC_MOUSE
MINT-1774976   ARHGC_HUMAN
MINT-6800783   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoinositide 3-kinase binding,
identical protein binding,
insulin-like growth factor receptor activity,
insulin binding,
metal ion binding,
insulin receptor binding,
insulin receptor substrate binding,
ATP binding,
insulin-like growth factor I binding		 microsome,
integral to plasma membrane		 positive regulation of DNA replication,
positive regulation of cell proliferation,
positive regulation of cell migration,
anti-apoptosis,
phosphoinositide 3-kinase cascade,
phosphoinositide-mediated signaling,
immune response,
protein amino acid autophosphorylation,
insulin receptor signaling pathway,
protein tetramerization
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 973 NNSRLGNGVLYASVNPEYFSA IGF1R 8550552
LTP
1.00
 CRK SH2;
Csk SH2		 -
0.16
 --
Y 973 NNSRLGNGVLYASVNPEYFSA IGF1R 8940173
LTP
1.00
 CRK SH2;
Csk SH2		 -
0.16
 --
Y 980 GVLYASVNPEYFSAADVYVPD IGF1R 8550552
LTP
1.00
 CRK SH2;
IRS1 PTB;
RASA_group SH2;
SHC PTB		 -
0.07
 1P4O 89.96%
Y 980 GVLYASVNPEYFSAADVYVPD IGF1R 8940173
LTP
1.00
 CRK SH2;
IRS1 PTB;
RASA_group SH2;
SHC PTB		 -
0.07
 1P4O 89.96%
Y 980 GVLYASVNPEYFSAADVYVPD - 7537849
LTP
1.00
 CRK SH2;
IRS1 PTB;
RASA_group SH2;
SHC PTB		 -
0.07
 1P4O 89.96%
Y 980 GVLYASVNPEYFSAADVYVPD - 7559478
LTP
1.00
 CRK SH2;
IRS1 PTB;
RASA_group SH2;
SHC PTB		 -
0.07
 1P4O 89.96%

Substrate: CAS-L (Docking protein)
Seq-ID: Q14511 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-50139   ITCH_HUMAN
MINT-62009   SMAD1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein binding focal adhesion,
spindle,
lamellipodium,
Golgi apparatus,
nucleus,
cell cortex		 cell division,
regulation of growth,
integrin-mediated signaling pathway,
signal transduction,
actin filament bundle assembly,
mitosis,
cell adhesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 166 TPVRTGHGYVYEYPSRYQKDV - 12522270
HTP
1.00
 ABL1 SH2;
CRKL SH2;
CRK SH2;
NCK SH2		 -
0.43
 - medium
Y 317 GQSVGSQNDAYDVPRGVQFLE - 18083107
HTP
1.00
 ABL1 SH2;
CRKL SH2;
CRK SH2;
NCK SH2		 -
0.70
 - medium
Y 345 KANPQERDGVYDVPLHNPPDA - 18083107
HTP
1.00
 ABL1 SH2;
CRKL SH2;
CRK SH2;
NCK SH2		 -
0.86
 - medium

Substrate: PDGF-R beta (Beta platelet-derived growth factor receptor)
Seq-ID: P09619 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-2832596   NHRF2_HUMAN
MINT-2832984   PTEN_HUMAN
MINT-2833042   NHRF1_HUMAN
MINT-6762380   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
vascular endothelial growth factor receptor activity,
platelet-derived growth factor binding,
platelet activating factor receptor activity,
platelet-derived growth factor receptor binding,
ATP binding,
platelet-derived growth factor beta-receptor activity		 integral to plasma membrane positive regulation of cell proliferation,
positive regulation of cell migration,
protein amino acid autophosphorylation,
peptidyl-tyrosine phosphorylation,
cell chemotaxis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 771 VKYADIESSNYMAPYDNYVPS PDGFR_beta 8195171
LTP
1.00
 CRK SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2		 TyrKc
0.25
 - medium

Substrate: EPHA3 (Receptor for member of the ephrinA family)
Seq-ID: P29320 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
ATP binding,
protein binding		 extracellular region,
integral to plasma membrane		 protein amino acid phosphorylation,
transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 596 GHLKLPGLRTYVDPHTYEDPT - 11870224
LTP
1.00
 CRK SH2 -
0.38
 2QO7 13.54%
Y 596 GHLKLPGLRTYVDPHTYEDPT - 8622983
LTP
1.00
 CRK SH2 -
0.38
 2QO7 13.54%
Y 602 GLRTYVDPHTYEDPTQAVHEF EphA3 11870224
LTP
1.00
 CRK SH2 -
0.39
 2QOD 13.97%

Substrate: Crk (The Crk protein contains a single SH2 and two SH3 domains in the order SH2-SH3-SH3)
Seq-ID: P46108 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-15716   CBL_HUMAN
MINT-17467   VAV_HUMAN
MINT-51245   SMAD3_HUMAN
MINT-72620   WASL_HUMAN
MINT-74497   EGFR_HUMAN
MINT-74498   ERBB2_HUMAN
MINT-74500   ERBB3_HUMAN
MINT-2855127   ATX1_HUMAN
MINT-6762904   IRS1_RAT
MINT-6763928   PAXI_HUMAN
MINT-6763936   BCAR1_HUMAN
MINT-7103547   MK08_HUMAN
MINT-7104372   ACK1_HUMAN
MINT-7235318   ABL1_MOUSE
MINT-7253878   SNX17_HUMAN
MINT-7253890   PHAR2_HUMAN
MINT-7253902   FANCA_HUMAN
MINT-7253974   AKAP6_HUMAN
MINT-7254022   MINT_HUMAN
MINT-7254046   AKAP2_HUMAN
MINT-7254082   ICAL_HUMAN
MINT-7254106   ABL1_HUMAN
MINT-7254130   ASAP2_HUMAN
MINT-7254142   FCG2B_HUMAN
MINT-7254154   FCG2C_HUMAN
MINT-7254202   ASAP1_HUMAN
MINT-7254250   DOCK1_HUMAN
MINT-7254262   RRAS_HUMAN
MINT-7254274   SOS1_HUMAN
MINT-7254286   RGS7_HUMAN
MINT-7254334   E41L3_HUMAN
MINT-7254406   DNLI3_HUMAN
MINT-7254430   RPGF1_HUMAN
MINT-7254454   DLGP4_HUMAN
MINT-7254478   SP1_HUMAN
MINT-7254490   FLNB_HUMAN
MINT-7254502   TGON2_HUMAN
MINT-7254514   C1QR1_HUMAN
MINT-7254526   GHR_HUMAN
MINT-7254538   SHAN2_HUMAN
MINT-7254550   SUV92_HUMAN
MINT-7254562   CELR2_HUMAN
MINT-7254574   ABL2_HUMAN
MINT-7254586   THOC2_HUMAN
MINT-7254634   ASPP2_HUMAN
MINT-7254658   TPX2_HUMAN
MINT-7254694   NFASC_HUMAN
MINT-7254706   STF1_HUMAN
MINT-7254718   FLNC_HUMAN
MINT-7254754   DDX41_HUMAN
MINT-7254766   MLL4_HUMAN
MINT-7254780   TRI39_HUMAN
MINT-7254804   M4K1_HUMAN
MINT-7254852   TAL1_HUMAN
MINT-7254864   ARHGB_HUMAN
MINT-7254876   FLNA_HUMAN
MINT-7254936   KIF22_HUMAN
MINT-7254948   BMX_HUMAN
MINT-7254960   DYN2_HUMAN
MINT-7254999   MY18B_HUMAN
MINT-7255074   RPP38_HUMAN
MINT-7255086   SNX3_HUMAN
MINT-7255245   PRIC3_HUMAN
MINT-7255257   BRD4_HUMAN
MINT-7255293   GCF_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH2 domain binding plasma membrane,
endosome,
cytosol,
nucleus		 actin cytoskeleton organization,
regulation of transcription from RNA polymerase II promoter
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 221 QPLGGPEPGPYAQPSVNTPLP - 12198159
LTP
0.31
 CRK SH2 -
0.84
 --
Y 221 QPLGGPEPGPYAQPSVNTPLP - 9642287
LTP
0.31
 CRK SH2 -
0.84
 --
Y 221 QPLGGPEPGPYAQPSVNTPLP - 9480991
LTP
0.31
 CRK SH2 -
0.84
 --
Y 221 QPLGGPEPGPYAQPSVNTPLP Abl 8194526
LTP
0.31
 CRK SH2 -
0.84
 --

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