List of substrates found:

VEGFR-1  VEGFR-2  ZAP70  SH3 domain-binding protein 2  c-met  SYK  LAT  TRKB 


Substrate: VEGFR-1 (Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity.)
Seq-ID: P17948 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
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Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 794 KRSSSEIKTDYLSIIMDPDEV - 11741094
LTP
0.97
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2
-
0.30
- low
Y 794 KRSSSEIKTDYLSIIMDPDEV - 9398617
LTP
0.97
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2
-
0.30
- low
Y 1169 QANVQQDGKDYIPINAILTGN - 11513746
LTP
1.00
PIK3R1 SH2;
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2
-
0.30
- low
Y 1169 QANVQQDGKDYIPINAILTGN - 9299537
LTP
1.00
PIK3R1 SH2;
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2
-
0.30
- low
Y 1333 PPPDYNSVVLYSTPPI      FLT1 11513746
LTP
0.46
CRK SH2;
NCK SH2;
PLCG_group SH2
-
0.37
- low
Y 1333 PPPDYNSVVLYSTPPI      FLT1 9722576
LTP
0.46
CRK SH2;
NCK SH2;
PLCG_group SH2
-
0.37
- low
Y 1333 PPPDYNSVVLYSTPPI      - 9600074
LTP
0.46
CRK SH2;
NCK SH2;
PLCG_group SH2
-
0.37
- low

Substrate: VEGFR-2 (Receptor tyrosine kinase)
Seq-ID: P35968 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 801 RANGGELKTGYLSIVMDPDEL - 11741094
LTP
1.00
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2
-
0.23
--
Y 1175 QANAQQDGKDYIVLPISETLS KDR 10579917
LTP
1.00
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2;
SHB SH2;
SHC2 SH2
-
0.41
--
Y 1175 QANAQQDGKDYIVLPISETLS KDR 11387210
LTP
1.00
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2;
SHB SH2;
SHC2 SH2
-
0.41
--
Y 1175 QANAQQDGKDYIVLPISETLS - 10749680
LTP
1.00
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2;
SHB SH2;
SHC2 SH2
-
0.41
--
Y 1175 QANAQQDGKDYIVLPISETLS - 14532277
LTP
1.00
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2;
SHB SH2;
SHC2 SH2
-
0.41
--

Substrate: ZAP70 (Cytoplasmic tyrosine kinase)
Seq-ID: P43403 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 315 PRPMPMDTSVYESPYSDPEEL ZAP70 11828374
LTP
1.00
CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2
-
0.69
2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL ZAP70 7798261
LTP
1.00
CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2
-
0.69
2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL - 12522270
HTP
1.00
CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2
-
0.69
2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL - 15592455
HTP
1.00
CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2
-
0.69
2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL - 16094384
HTP
1.00
CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2
-
0.69
2OZO 6.42%
Y 315 PRPMPMDTSVYESPYSDPEEL ZAP70 10037717
LTP
1.00
CRKL SH2;
CRK SH2;
PLCG1 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV_group SH2
-
0.69
2OZO 6.42%
Y 319 PMDTSVYESPYSDPEELKDKK - 10202147
LTP
1.00
CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2
-
0.52
2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 10318843
LTP
1.00
CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2
-
0.52
2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 12522270
HTP
1.00
CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2
-
0.52
2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 15592455
HTP
1.00
CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2
-
0.52
2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 16094384
HTP
1.00
CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2
-
0.52
2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 10037717
LTP
1.00
CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2
-
0.52
2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 15268851
LTP
1.00
CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2
-
0.52
2OZO 1.83%
Y 319 PMDTSVYESPYSDPEELKDKK - 15292262
LTP
1.00
CRKL SH2;
CRK SH2;
Lck SH2;
PLCG1 SH2;
PLCG_group SH2
-
0.52
2OZO 1.83%

Substrate: SH3 domain-binding protein 2 (Adaptor molecule)
Seq-ID: P78314 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
SH3/SH2 adaptor activity
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 183 DYEHDDEDDSYLEPDSPEPGR - 11390470
LTP
1.00
PLCG1 SH2;
PLCG2 SH2;
PLCG_group SH2;
VAV1 SH2;
VAV2 SH2;
VAV_group SH2
-
0.89
- medium

Substrate: c-met (Receptor tyrosine kinase for hepatocyte growth factor.)
Seq-ID: P08581 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1349 AIFSTFIGEHYVHVNATYVNV Met 12475979
LTP
1.00
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.03
3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV - 9444958
LTP
1.00
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.03
3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV - 9252406
LTP
1.00
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.03
3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV - 7513258
LTP
1.00
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.03
3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV Met 7731718
LTP
1.00
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.03
3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV Met 7687741
LTP
1.00
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.03
3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV - 9826708
LTP
1.00
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.03
3F66 100.00%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 12475979
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 9444958
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 9252406
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 7513258
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP Met 7731718
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 8662889
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP Met 7961992
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP Met 7687741
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 9826708
LTP
1.00
GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2
-
0.06
1R0P 15.72%

Substrate: SYK (Spleen tyrosine kinase )
Seq-ID: P48025 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 342 REALPMDTEVYESPYADPEEI SYK 8657103
LTP
1.00
PLCG_group SH2;
VAV1 SH2
-
0.58
--
Y 342 REALPMDTEVYESPYADPEEI Lyn 9820500
LTP
1.00
PLCG_group SH2;
VAV1 SH2
-
0.58
--
Y 346 PMDTEVYESPYADPEEIRPKE SYK 8657103
LTP
1.00
PLCG_group SH2 -
0.54
--
Y 346 PMDTEVYESPYADPEEIRPKE Lyn 9820500
LTP
1.00
PLCG_group SH2 -
0.54
--

Substrate: LAT (Adaptor molecule involved in the TCR signal pathway)
Seq-ID: O54957 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 136 DEDEDDYPNGYLVVLPDSSPA - 10811803
LTP
0.00
PLCG_group SH2 -
0.77
- low
Y 136 DEDEDDYPNGYLVVLPDSSPA ZAP70 11368773
LTP
0.00
PLCG_group SH2 -
0.77
- low
Y 136 DEDEDDYPNGYLVVLPDSSPA ZAP70 11457888
LTP
0.00
PLCG_group SH2 -
0.77
- low

Substrate: TRKB (Receptor for brain-derived neurothrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5.)
Seq-ID: P15209 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 816 LQNLAKASPVYLDILG      TRKB 8106527
LTP
1.00
PLCG_group SH2 -
0.07
- medium
Y 816 LQNLAKASPVYLDILG      TRKB 9582017
LTP
1.00
PLCG_group SH2 -
0.07
- medium
Y 816 LQNLAKASPVYLDILG      TRKB 10533983
LTP
1.00
PLCG_group SH2 -
0.07
- medium


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