List of substrates found:

Vav  CD31  IL-4R alpha  EGFR  Epo-R  SLP-76  CD22  FCGR2B  c-kit  Common beta c subunit  LAIR1  SIGLEC10  CD33  ROS1 


Substrate: Vav (Adaptor molecule. GDP/GTP exchange factor in Rho/Rac molecule)
Seq-ID: P15498 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-17467   CRK_HUMAN
MINT-2837376   PLCG1_BOVIN
MINT-4549720   3BP2_HUMAN
MINT-6743318   RAC1_HUMAN
MINT-6743347   RHOA_HUMAN
MINT-6743356   CDC42_HUMAN
MINT-7226634   ITB2_HUMAN
MINT-7226674   ABL1_HUMAN
MINT-7300569   KHDR1_MOUSE
MINT-7300587   KHDR1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
Rho guanyl-nucleotide exchange factor activity,
metal ion binding,
sequence-specific DNA binding transcription factor activity,
protein binding		 plasma membrane,
cytosol		 induction of apoptosis by extracellular signals,
apoptosis,
regulation of Rho protein signal transduction
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 174 ENEEAEGDEIYEDLMRSEPVS - 898671
LTP
1.00
 Fyn SH2;
PTPN6 SH2		 -
0.54
 - medium
Y 174 ENEEAEGDEIYEDLMRSEPVS - 10669745
LTP
1.00
 Fyn SH2;
PTPN6 SH2		 -
0.54
 - medium

Substrate: CD31 (Adhesion molecule)
Seq-ID: P16284 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-61866   PR40A_HUMAN
MINT-63486   KU70_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein binding cell junction,
integral to membrane,
extracellular space,
platelet alpha granule membrane		 signal transduction,
diapedesis,
cell recognition,
cell adhesion,
phagocytosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 690 NKEPLNSDVQYTEVQVSSAES - 15201144
LTP
1.00
 INPP5D SH2;
PLCG1 SH2;
PTPN11 SH2;
PTPN6 SH2;
Src SH2		 -
0.58
 - medium
Y 713 DLGKKDTETVYSEVRKAVPDA - 15592455
HTP
1.00
 PLCG1 SH2;
PTPN11 SH2;
PTPN6 SH2;
Src SH2		 -
0.63
 - medium
Y 713 DLGKKDTETVYSEVRKAVPDA - 18088087
HTP
1.00
 PLCG1 SH2;
PTPN11 SH2;
PTPN6 SH2;
Src SH2		 -
0.63
 - medium
Y 713 DLGKKDTETVYSEVRKAVPDA - 18083107
HTP
1.00
 PLCG1 SH2;
PTPN11 SH2;
PTPN6 SH2;
Src SH2		 -
0.63
 - medium

Substrate: IL-4R alpha (Cytokin receptor)
Seq-ID: P24394 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
MINT-63292   ARI2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor signaling protein activity,
interleukin-4 receptor activity		 extracellular region,
integral to plasma membrane		 immune response
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 575 AAPVSAPTSGYQEFVHAVEQG - 10358772
LTP
1.00
 PTPN6 SH2;
STAT6 SH2		 -
0.58
 - medium
Y 713 LVDSLGSGIVYSALTCHLCGH - 9670964
LTP
1.00
 INPP5D SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2		 -
0.17
 - medium

Substrate: EGFR (Receptor for EGF and other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor,)
Seq-ID: P00533 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16802   GRB10_HUMAN
MINT-50935   1433Z_HUMAN
MINT-51101   ANXA1_HUMAN
MINT-51490   ARBK1_HUMAN
MINT-60973   CBL_HUMAN
MINT-61486   CRKL_HUMAN
MINT-61487   CSK_HUMAN
MINT-61490   STA5B_HUMAN
MINT-61540   GRB2_HUMAN
MINT-68514   PDC6I_HUMAN
MINT-74427   ABL1_HUMAN
MINT-74438   ABL2_HUMAN
MINT-74460   ANS1A_HUMAN
MINT-74469   APBB1_HUMAN
MINT-74479   DP13A_HUMAN
MINT-74487   BMX_HUMAN
MINT-74497   CRK_HUMAN
MINT-74535   FES_HUMAN
MINT-74551   IRS1_HUMAN
MINT-74555   IRS4_HUMAN
MINT-74562   JAK2_HUMAN
MINT-74566   SH2B3_HUMAN
MINT-74572   JIP1_HUMAN
MINT-74587   NCK1_HUMAN
MINT-74593   NUMB_HUMAN
MINT-74594   NUMBL_HUMAN
MINT-74606   P85A_HUMAN
MINT-74630   P85B_HUMAN
MINT-74659   P55G_HUMAN
MINT-74678   PLCG1_HUMAN
MINT-74685   PLCG2_HUMAN
MINT-74687   PTK6_HUMAN
MINT-74689   PTN11_HUMAN
MINT-74711   RASA1_HUMAN
MINT-74717   SH2B1_HUMAN
MINT-74720   SH22A_HUMAN
MINT-74732   SHC1_HUMAN
MINT-74746   SLAP1_HUMAN
MINT-74763   KSYK_HUMAN
MINT-74790   TLN1_HUMAN
MINT-74807   ZAP70_HUMAN
MINT-1788719   ERBB2_HUMAN
MINT-6169667   ESR1_HUMAN
MINT-6170031   SOS1_MOUSE
MINT-6170198   SH3G2_HUMAN
MINT-6170268   SH3K1_HUMAN
MINT-6793358   PTN1_HUMAN
MINT-7980526   TM1L1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
epidermal growth factor receptor activity,
protein heterodimerization activity,
identical protein binding,
receptor signaling protein tyrosine kinase activity,
double-stranded DNA binding,
ATP binding,
protein phosphatase binding,
actin filament binding,
MAP/ERK kinase kinase activity		 Shc-EGFR complex,
endosome,
basolateral plasma membrane,
integral to membrane,
extracellular space,
nucleus		 activation of phospholipase C activity,
protein insertion into membrane,
response to UV-A,
positive regulation of nitric oxide biosynthetic process,
positive regulation of cell migration,
positive regulation of cyclin-dependent protein kinase activity involved in G1/S,
positive regulation of catenin protein nuclear translocation,
regulation of nitric-oxide synthase activity,
positive regulation of protein kinase B signaling cascade,
ossification,
positive regulation of epithelial cell proliferation,
activation of phospholipase A2 activity by calcium-mediated signaling,
cell-cell adhesion,
regulation of peptidyl-tyrosine phosphorylation,
positive regulation of phosphorylation,
positive regulation of MAP kinase activity,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1092 IDDTFLPVPEYINQSVPKRPA EGFR 8845374
LTP
0.05
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2		 -
0.57
 --
Y 1092 IDDTFLPVPEYINQSVPKRPA - 15302935
HTP
0.05
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2		 -
0.57
 --
Y 1092 IDDTFLPVPEYINQSVPKRPA - 17081983
HTP
0.05
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2		 -
0.57
 --
Y 1092 IDDTFLPVPEYINQSVPKRPA - 18083107
HTP
0.05
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2		 -
0.57
 --
Y 1172 SHQISLDNPDYQQDFFPKEAK EGFR 8845374
LTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 PTB;
SHC3 PTB;
Src SH2;
VAV2 SH2		 -
0.67
 --
Y 1172 SHQISLDNPDYQQDFFPKEAK - 15302935
HTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 PTB;
SHC3 PTB;
Src SH2;
VAV2 SH2		 -
0.67
 --
Y 1172 SHQISLDNPDYQQDFFPKEAK - 17081983
HTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 PTB;
SHC3 PTB;
Src SH2;
VAV2 SH2		 -
0.67
 --
Y 1172 SHQISLDNPDYQQDFFPKEAK - 18083107
HTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 PTB;
SHC3 PTB;
Src SH2;
VAV2 SH2		 -
0.67
 --
Y 1197 FKGSTAENAEYLRVAPQSSEF EGFR 8845374
LTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2		 -
0.54
 --
Y 1197 FKGSTAENAEYLRVAPQSSEF - 15302935
HTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2		 -
0.54
 --
Y 1197 FKGSTAENAEYLRVAPQSSEF - 17081983
HTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2		 -
0.54
 --
Y 1197 FKGSTAENAEYLRVAPQSSEF - 18083107
HTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2		 -
0.54
 --

Substrate: Epo-R (Receptor for erythropoietin, a major activator of erythropoiesis)
Seq-ID: P19235 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-73504   PTN6_HUMAN
MINT-74896   PTN6_MOUSE
MINT-6794748   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
erythropoietin receptor activity extracellular region,
integral to plasma membrane
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 454 ELPPTPPHLKYLYLVVSDSGI - 10579919
LTP
0.96
 CISH SH2;
PTPN6 SH2;
SOCS3 SH2;
STAT5 SH2;
SYK SH2		 -
0.37
 - low
Y 454 ELPPTPPHLKYLYLVVSDSGI - 12027890
LTP
0.96
 CISH SH2;
PTPN6 SH2;
SOCS3 SH2;
STAT5 SH2;
SYK SH2		 -
0.37
 - low

Substrate: SLP-76 (Adaptor molecule; involved in T cell AG receptor mediate signaling)
Seq-ID: Q13094 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-15244   FYB_HUMAN
MINT-16513   SHC1_HUMAN
MINT-16846   CBL_HUMAN
MINT-17488   FCGR1_HUMAN
MINT-59471   ITK_MOUSE
MINT-59473   ITK_HUMAN
MINT-59474   LCK_HUMAN
MINT-2837400   PLCG1_BOVIN
MINT-4302560   STAM1_HUMAN
MINT-4302608   STAM2_HUMAN
MINT-7041321   GRAP2_HUMAN
MINT-7306527   NCK1_HUMAN
MINT-7306585   SRC_CHICK
MINT-7306598   SRC_HUMAN
MINT-7306611   FYN_HUMAN
MINT-7306624   P85A_HUMAN
MINT-7306637   PLCG1_HUMAN
MINT-7306657   GRB2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein binding cytosol immune response,
transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 113 GGWSSFEEDDYESPNDDQDGE - 8892604
LTP
0.99
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.92
 - medium
Y 113 GGWSSFEEDDYESPNDDQDGE ZAP70 9047237
LTP
0.99
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.92
 - medium
Y 113 GGWSSFEEDDYESPNDDQDGE SYK 15388330
LTP
0.99
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.92
 - medium
Y 113 GGWSSFEEDDYESPNDDQDGE ZAP70 12817019
LTP
0.99
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.92
 - medium
Y 113 GGWSSFEEDDYESPNDDQDGE Lck 8702662
LTP
0.99
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.92
 - medium
Y 113 GGWSSFEEDDYESPNDDQDGE ZAP70 8702662
LTP
0.99
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.92
 - medium
Y 128 DDQDGEDDGDYESPNEEEEAP - 8892604
LTP
0.30
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.98
 - medium
Y 128 DDQDGEDDGDYESPNEEEEAP ZAP70 9047237
LTP
0.30
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.98
 - medium
Y 128 DDQDGEDDGDYESPNEEEEAP SYK 15388330
LTP
0.30
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.98
 - medium
Y 128 DDQDGEDDGDYESPNEEEEAP ZAP70 12817019
LTP
0.30
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.98
 - medium
Y 128 DDQDGEDDGDYESPNEEEEAP Lck 8702662
LTP
0.30
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.98
 - medium
Y 128 DDQDGEDDGDYESPNEEEEAP ZAP70 8702662
LTP
0.30
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.98
 - medium
Y 145 EEAPVEDDADYEPPPSNDEEA TXK 8892604
LTP
1.00
 ITK SH2;
NCK SH2;
PTPN6 SH2;
VAV1 SH2		 -
0.97
 - medium
Y 145 EEAPVEDDADYEPPPSNDEEA ZAP70 8892604
LTP
1.00
 ITK SH2;
NCK SH2;
PTPN6 SH2;
VAV1 SH2		 -
0.97
 - medium

Substrate: CD22 (protein binding)
Seq-ID: P20273 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
sugar binding,
protein binding		 cell adhesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 842 ERPQAQENVDYVILKH      - 16393971
LTP
1.00
 PTPN6 SH2 -
0.49
 - low

Substrate: FCGR2B (protein binding)
Seq-ID: P31994 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-74919   PTN6_HUMAN
MINT-74920   SHIP1_HUMAN
MINT-7245214   SRC_HUMAN
MINT-7247446   FYN_HUMAN
MINT-7251178   NCK1_HUMAN
MINT-7252786   PLCG1_HUMAN
MINT-7254142   CRK_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor activity,
IgG binding		 plasma membrane,
integral to membrane		 immune response,
interspecies interaction between organisms
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 292 DKVGAENTITYSLLMHPDALE Lyn 8756631
LTP
1.00
 INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2		 -
0.42
 - low
Y 292 DKVGAENTITYSLLMHPDALE BLK 8756631
LTP
1.00
 INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2		 -
0.42
 - low

Substrate: c-kit (Receptor tyrosine kinase)
Seq-ID: P10721 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor signaling protein tyrosine kinase activity,
ATP binding,
protein binding		 integral to membrane,
extracellular space		 male gonad development,
transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 568 KVVEEINGNNYVYIDPTQLPY Kit 9799234
LTP
1.00
 Fyn SH2;
MATK SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2		 -
0.13
 --
Y 570 VEEINGNNYVYIDPTQLPYDH Kit 9799234
LTP
1.00
 Fyn SH2;
MATK SH2;
PTPN6 SH2;
SHC1 SH2		 -
0.13
 --

Substrate: Common beta c subunit (Cytokine recpetor common beta chain)
Seq-ID: P32927 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cytokine receptor activity granulocyte macrophage colony-stimulating factor receptor complex respiratory gaseous exchange
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 628 QKSPPPGSLEYLCLPAGGQVQ - 9257712
LTP
1.00
 PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2;
STAT5 SH2		 -
0.71
 - medium
Y 628 QKSPPPGSLEYLCLPAGGQVQ - 10362354
LTP
1.00
 PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2;
STAT5 SH2		 -
0.71
 - medium

Substrate: LAIR1 (Cell surface receptor)
Seq-ID: Q6GTX8 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor activity,
protein binding		 plasma membrane,
integral to membrane
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 251 LAAGSSQEVTYAQLDHWALTQ - 10764762
LTP
0.28
 PTPN11 SH2;
PTPN6 SH2		 -
0.33
 - low
Y 281 STKPMAESITYAAVARH     - 10764762
LTP
1.00
 PTPN6 SH2 -
0.59
 - low

Substrate: SIGLEC10 (cell adhesion molecule)
Seq-ID: Q96LC7 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
sugar binding plasma membrane,
extracellular region,
integral to membrane		 cell adhesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 667 ESQESQEELHYATLNFPGVRP Lck 11733002
LTP
1.00
 PTPN6 SH2 -
0.78
 - low
Y 667 ESQESQEELHYATLNFPGVRP ITK 11733002
LTP
1.00
 PTPN6 SH2 -
0.78
 - low
Y 667 ESQESQEELHYATLNFPGVRP JAK3 11733002
LTP
1.00
 PTPN6 SH2 -
0.78
 - low

Substrate: CD33 (CD antigen)
Seq-ID: P20138 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
sugar binding,
receptor activity		 integral to plasma membrane negative regulation of cell proliferation,
cell-cell signaling,
cell adhesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 340 PTVEMDEELHYASLNFHGMNP - 10206955
LTP
1.00
 PTPN11 SH2;
PTPN6 SH2		 -
0.54
 - low
Y 340 PTVEMDEELHYASLNFHGMNP Lck 10887109
LTP
1.00
 PTPN11 SH2;
PTPN6 SH2		 -
0.54
 - low
Y 340 PTVEMDEELHYASLNFHGMNP SRC 10887109
LTP
1.00
 PTPN11 SH2;
PTPN6 SH2		 -
0.54
 - low

Substrate: ROS1 (Ros proto-oncogene tyrosine kinase (from PhosphoBase))
Seq-ID: P08922 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-6799814   PTN1_HUMAN
MINT-6799844   PTN6_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transmembrane receptor protein tyrosine kinase activity,
ATP binding,
protein binding		 membrane fraction,
sodium:potassium-exchanging ATPase complex		 protein amino acid phosphorylation,
transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 2274 METKNREGLNYMVLATECGQG - 15456853
LTP
1.00
 PTPN6 SH2 -
0.42
 - medium
Y 2334 CPSGKPEGLNYACLTHSGYGD - 15456853
LTP
1.00
 PTPN6 SH2 -
0.37
 - medium

Valid HTML 4.01 Transitional