List of substrates found:

ZAP70  TRKB  G-CSF-R  Bcr  Gab1  Gab2  Common beta c subunit  PDGF-R beta  c-met  ErbB3  ErbB2 


Substrate: ZAP70 (Cytoplasmic tyrosine kinase)
Seq-ID: P43403 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-59476   LCK_HUMAN
MINT-60980   SHC1_HUMAN
MINT-74806   ERBB3_HUMAN
MINT-74807   EGFR_HUMAN
MINT-3374106   HS90A_HUMAN
MINT-3382488   LAT_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
non-membrane spanning protein tyrosine kinase activity,
ATP binding		 cytosol,
T cell receptor complex		 positive thymic T cell selection,
immune response,
intracellular protein kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 474 ARNVLLVNRHYAKISDFGLSK Lck 9685404
LTP
1.00
 SHC_group SH2 TyrKc
0.07
 1U59 13.97%

Substrate: TRKB (Receptor for brain-derived neurothrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5.)
Seq-ID: P15209 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transmembrane receptor protein tyrosine kinase activity,
ATP binding		 cytosol,
integral to plasma membrane,
terminal button		 regulation of metabolic process,
feeding behavior,
vasculogenesis,
glutamate secretion,
mechanoreceptor differentiation,
retinal rod cell development
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 515 TKIPVIENPQYFGITNSQLKP TRKB 9582017
LTP
1.00
 SHC_group SH2 -
0.26
 - medium
Y 515 TKIPVIENPQYFGITNSQLKP TRKB 10533983
LTP
1.00
 SHC_group SH2 -
0.26
 - medium

Substrate: G-CSF-R (Granulocyte colony stimulating factor receptor)
Seq-ID: P40223 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cytokine receptor activity integral to membrane neutrophil chemotaxis,
cell adhesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 788 LGGPTPSPKSYENIWFHSRPQ - 8608222
LTP
1.00
 GRB2 SH2;
PTPN11 SH2;
SHC_group SH2		 -
0.60
 - medium

Substrate: Bcr (Breakpoint cluster region protein)
Seq-ID: P11274 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-69534   AT2B1_HUMAN
MINT-69536   CLH1_HUMAN
MINT-69537   CFTR_HUMAN
MINT-69540   ZO2_HUMAN
MINT-69542   RGS12_HUMAN
MINT-4961172   AFAD_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
Rho guanyl-nucleotide exchange factor activity,
protein serine/threonine kinase activity,
ATP binding,
GTPase activator activity		 intracellular protein amino acid phosphorylation,
signal transduction,
regulation of Rho protein signal transduction
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 276 GSRPPWPPLEYQPYQSIYVGG Fes 8955135
LTP
0.00
 ABL1 SH2;
GRB10 SH2;
GRB2 SH2;
SHC1 SH2;
SHC_group SH2		 -
0.58
 - medium
Y 279 PPWPPLEYQPYQSIYVGGMME Fes 8955135
LTP
1.00
 ABL1 SH2;
GRB10 SH2;
GRB2 SH2;
SHC1 SH2;
SHC_group SH2		 -
0.58
 - medium
Y 283 PLEYQPYQSIYVGGMMEGEGK Fes 8955135
LTP
1.00
 ABL1 SH2;
GRB10 SH2;
GRB2 SH2;
SHC1 SH2;
SHC_group SH2		 -
0.61
 - medium

Substrate: Gab1 (Multisubstrate docking protein downstream in the signaling pathways of different RTK.)
Seq-ID: Q13480 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-58395   GRB2_HUMAN
MINT-58403   GRAP2_HUMAN
MINT-58404   MET_HUMAN
MINT-68564   BMX_HUMAN
MINT-1893011   P85A_HUMAN
MINT-6169406   PTN11_HUMAN
MINT-6169502   PAXI_HUMAN
MINT-7971128   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3/SH2 adaptor activity cytosol epidermal growth factor receptor signaling pathway,
insulin receptor signaling pathway,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 406 LRKDASSQDCYDIPRAFPSDR EGFR 9890893
LTP
1.00
 CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2;
SHC_group SH2		 -
0.61
 - low
Y 406 LRKDASSQDCYDIPRAFPSDR - 10753869
LTP
1.00
 CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2;
SHC_group SH2		 -
0.61
 - low
Y 406 LRKDASSQDCYDIPRAFPSDR Met 10734310
LTP
1.00
 CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2;
SHC_group SH2		 -
0.61
 - low
Y 406 LRKDASSQDCYDIPRAFPSDR - 18083107
HTP
1.00
 CRKL SH2;
CRK SH2;
NCK SH2;
PLCG1 SH2;
SHC_group SH2		 -
0.61
 - low

Substrate: Gab2 (Adaptor molecule)
Seq-ID: Q9Z1S8 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphatidylinositol-3,4-bisphosphate binding,
phosphatidylinositol-3,4,5-trisphosphate binding,
transmembrane receptor protein tyrosine kinase adaptor protein activity		 plasma membrane,
cytoplasm		 positive regulation of cell proliferation,
cell migration,
integrin-mediated signaling pathway,
phosphoinositide-mediated signaling,
positive regulation of mast cell degranulation,
osteoclast differentiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 193 PTLSTSAPQEYLYLHQCISRR SRC_group 12819203
LTP
0.93
 SHC_group SH2 -
0.41
 - medium

Substrate: Common beta c subunit (Cytokine recpetor common beta chain)
Seq-ID: P32927 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cytokine receptor activity granulocyte macrophage colony-stimulating factor receptor complex respiratory gaseous exchange
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 593 QASSFDFNGPYLGPPHSRSLP - 9257712
LTP
1.00
 PTPN11 SH2;
SHC1 PTB;
SHC_group SH2		 -
0.76
 - medium
Y 593 QASSFDFNGPYLGPPHSRSLP - 10362354
LTP
1.00
 PTPN11 SH2;
SHC1 PTB;
SHC_group SH2		 -
0.76
 - medium
Y 766 PGPVKSGFEGYVELPPIEGRS - 9257712
LTP
1.00
 PTPN11 SH2;
SHC1 SH2;
SHC_group SH2;
STAT5 SH2		 -
0.69
 - medium

Substrate: PDGF-R beta (Beta platelet-derived growth factor receptor)
Seq-ID: P09619 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-2832596   NHRF2_HUMAN
MINT-2832984   PTEN_HUMAN
MINT-2833042   NHRF1_HUMAN
MINT-6762380   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
vascular endothelial growth factor receptor activity,
platelet-derived growth factor binding,
platelet activating factor receptor activity,
platelet-derived growth factor receptor binding,
ATP binding,
platelet-derived growth factor beta-receptor activity		 integral to plasma membrane positive regulation of cell proliferation,
positive regulation of cell migration,
protein amino acid autophosphorylation,
peptidyl-tyrosine phosphorylation,
cell chemotaxis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 579 IESVSSDGHEYIYVDPMQLPY PDGFR_beta 8195171
LTP
1.00
 Fyn SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2;
SLA SH2;
Src SH2;
STAT5 SH2;
YES1 SH2		 -
0.15
 - medium
Y 740 VSLTGESDGGYMDMSKDESVD PDGFR_beta 8195171
LTP
1.00
 Fyn SH2;
NCK SH2;
PIK3R1 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2		 TyrKc
0.45
 - medium
Y 751 MDMSKDESVDYVPMLDMKGDV PDGFR_beta 8195171
LTP
1.00
 Fyn SH2;
NCK SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2;
Src SH2		 TyrKc
0.29
 - medium
Y 751 MDMSKDESVDYVPMLDMKGDV PDGFR_group 8195171
LTP
1.00
 Fyn SH2;
NCK SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2;
Src SH2		 TyrKc
0.29
 - medium
Y 771 VKYADIESSNYMAPYDNYVPS PDGFR_beta 8195171
LTP
1.00
 CRK SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2		 TyrKc
0.25
 - medium

Substrate: c-met (Receptor tyrosine kinase for hepatocyte growth factor.)
Seq-ID: P08581 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-18299   RANB9_HUMAN
MINT-58374   GAB1_MOUSE
MINT-58404   GAB1_HUMAN
MINT-6539587   CBL_HUMAN
MINT-6787689   PTN1_HUMAN
MINT-6798640   PTN11_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
hepatocyte growth factor receptor activity,
ATP binding,
protein binding		 integral to plasma membrane,
basal plasma membrane		 protein amino acid phosphorylation,
multicellular organismal development,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1349 AIFSTFIGEHYVHVNATYVNV Met 12475979
LTP
1.00
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.03
 3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV - 9444958
LTP
1.00
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.03
 3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV - 9252406
LTP
1.00
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.03
 3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV - 7513258
LTP
1.00
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.03
 3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV Met 7731718
LTP
1.00
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.03
 3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV Met 7687741
LTP
1.00
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.03
 3F66 100.00%
Y 1349 AIFSTFIGEHYVHVNATYVNV - 9826708
LTP
1.00
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.03
 3F66 100.00%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 12475979
LTP
1.00
 GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.06
 1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 9444958
LTP
1.00
 GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.06
 1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 9252406
LTP
1.00
 GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.06
 1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 7513258
LTP
1.00
 GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.06
 1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP Met 7731718
LTP
1.00
 GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.06
 1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 8662889
LTP
1.00
 GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.06
 1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP Met 7961992
LTP
1.00
 GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.06
 1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP Met 7687741
LTP
1.00
 GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.06
 1R0P 15.72%
Y 1356 GEHYVHVNATYVNVKCVAPYP - 9826708
LTP
1.00
 GRB2 SH2;
INPP5D SH2;
INPPL1 SH2;
PIK3R1 SH2;
PLCG1 SH2;
PLCG_group SH2;
SHC_group SH2;
Src SH2		 -
0.06
 1R0P 15.72%

Substrate: ErbB3 (Receptor tyrosine kinase)
Seq-ID: P21860 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-61514   CSK_HUMAN
MINT-61518   GRB2_HUMAN
MINT-61520   P85B_HUMAN
MINT-74430   ABL1_HUMAN
MINT-74454   ABL2_HUMAN
MINT-74500   CRK_HUMAN
MINT-74505   CRKL_HUMAN
MINT-74509   DAB1_HUMAN
MINT-74510   DAPP1_HUMAN
MINT-74534   FER_HUMAN
MINT-74539   FGFR1_HUMAN
MINT-74548   GRB7_HUMAN
MINT-74550   HCK_HUMAN
MINT-74559   ITK_HUMAN
MINT-74563   JAK2_HUMAN
MINT-74564   JAK3_HUMAN
MINT-74569   SH2B3_HUMAN
MINT-74588   NCK1_HUMAN
MINT-74592   NCK2_HUMAN
MINT-74617   P85A_HUMAN
MINT-74672   P55G_HUMAN
MINT-74682   PLCG1_HUMAN
MINT-74688   PTK6_HUMAN
MINT-74708   RASA1_HUMAN
MINT-74714   RIN1_HUMAN
MINT-74738   SHC1_HUMAN
MINT-74753   SRC_HUMAN
MINT-74775   KSYK_HUMAN
MINT-74784   TENC1_HUMAN
MINT-74788   TENS3_HUMAN
MINT-74795   TXK_HUMAN
MINT-74803   VAV2_HUMAN
MINT-74806   ZAP70_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein heterodimerization activity,
transmembrane receptor protein tyrosine kinase activity,
receptor signaling protein tyrosine kinase activity,
protein homodimerization activity,
protein tyrosine kinase activator activity,
ATP binding,
growth factor binding		 receptor complex,
basolateral plasma membrane,
integral to plasma membrane,
extracellular space		 protein amino acid phosphorylation,
positive regulation of phosphoinositide 3-kinase cascade,
negative regulation of signal transduction,
phosphoinositide 3-kinase cascade,
heart development,
negative regulation of secretion,
neuron apoptosis,
negative regulation of neuron apoptosis,
regulation of cell proliferation,
negative regulation of cell adhesion,
transmembrane receptor protein tyrosine kinase signaling pathway,
cranial nerve development,
wound healing,
Schwann cell differentiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1328 ATDSAFDNPDYWHSRLFPKAN - 9694850
LTP
1.00
 SHC1 PTB;
SHC_group SH2		 -
0.50
 - medium

Substrate: ErbB2 (Receptor tyrosine kinase)
Seq-ID: P04626 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-61505   P85B_HUMAN
MINT-74429   ABL1_HUMAN
MINT-74444   ABL2_HUMAN
MINT-74462   ANS1A_HUMAN
MINT-74470   APBB1_HUMAN
MINT-74486   BLNK_HUMAN
MINT-74488   BMX_HUMAN
MINT-74498   CRK_HUMAN
MINT-74502   CRKL_HUMAN
MINT-74508   DAB1_HUMAN
MINT-74512   DOK1_HUMAN
MINT-74521   SPT6H_HUMAN
MINT-74533   FER_HUMAN
MINT-74538   FGR_HUMAN
MINT-74540   GRAP2_HUMAN
MINT-74542   GRB2_HUMAN
MINT-74544   GRB7_HUMAN
MINT-74553   IRS1_HUMAN
MINT-74556   IRS4_HUMAN
MINT-74558   ITK_HUMAN
MINT-74561   JAK1_HUMAN
MINT-74567   SH2B3_HUMAN
MINT-74575   JIP1_HUMAN
MINT-74582   MATK_HUMAN
MINT-74590   NCK2_HUMAN
MINT-74610   P85A_HUMAN
MINT-74664   P55G_HUMAN
MINT-74680   PLCG1_HUMAN
MINT-74686   PLCG2_HUMAN
MINT-74691   PTN11_HUMAN
MINT-74712   RASA1_HUMAN
MINT-74713   RIN1_HUMAN
MINT-74722   SH22A_HUMAN
MINT-74723   SH23A_HUMAN
MINT-74724   3BP2_HUMAN
MINT-74737   SHC1_HUMAN
MINT-74747   SLAP1_HUMAN
MINT-74755   STAT1_HUMAN
MINT-74756   STAT3_HUMAN
MINT-74769   KSYK_HUMAN
MINT-74777   TEC_HUMAN
MINT-74781   TENC1_HUMAN
MINT-74786   TENS3_HUMAN
MINT-74793   TLN1_HUMAN
MINT-74794   TXK_HUMAN
MINT-74802   VAV2_HUMAN
MINT-1788719   EGFR_HUMAN
MINT-1901925   LAP2_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
epidermal growth factor receptor activity,
ErbB-3 class receptor binding,
protein heterodimerization activity,
DNA binding,
protein C-terminus binding,
identical protein binding,
receptor signaling protein tyrosine kinase activity,
ATP binding,
protein phosphatase binding		 receptor complex,
integral to membrane,
nucleus,
perinuclear region of cytoplasm		 regulation of angiogenesis,
transcription,
regulation of transcription,
phosphoinositide 3-kinase cascade,
phosphoinositide-mediated signaling,
heart development,
positive regulation of cell adhesion,
protein amino acid autophosphorylation,
positive regulation of epithelial cell proliferation,
wound healing,
positive regulation of MAP kinase activity,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1221 PAFSPAFDNLYYWDQDPPERG ErbB2 11500516
LTP
0.19
 GRB2 SH2;
SHC1 SH2;
SHC_group SH2		 -
0.67
 - low
Y 1222 AFSPAFDNLYYWDQDPPERGA ErbB2 11500516
LTP
1.00
 SHC_group SH2;
STAT3 SH2		 -
0.68
 - low

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