a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

Histone deacetylase 4  Raf1  HDAC7A  Integrin beta 2  RIN1  Cytokeratin 18  BAD  Pde3a  WEE 1 tyrosine kinase  Fam64a  Potassium voltage-gated channel subfamily H member 2  SLP-76  cdc25c  hnRNP C1 / hnRNP C2  PCTAIRE1  Orphan nuclear receptor NR4A1  p53  Kinase suppressor of ras-1 

Substrate:	Histone deacetylase 4 (Enzyme: Deacetylase)
Seq-ID:	P56524 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-49703   MEF2A_HUMAN MINT-49706   MEF2C_HUMAN MINT-3296491   1433Z_HUMAN MINT-3975818   1433S_HUMAN MINT-6802058   HIF1A_HUMAN MINT-7144512   ZN148_HUMAN MINT-7299965   BUB1B_HUMAN MINT-7555703   ATF2_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process potassium ion binding, transcription repressor binding, specific transcriptional repressor activity, transcription activator binding, transcription activator activity, histone deacetylase activity, histone deacetylase binding, zinc ion binding histone deacetylase complex, transcriptional repressor complex B cell differentiation, negative regulation of gene-specific transcription from RNA polymerase II promoter, nervous system development, positive regulation of cell proliferation, negative regulation of transcription factor activity, positive regulation of gene-specific transcription from RNA polymerase II promoter, negative regulation of myotube differentiation, transcription, histone H4 deacetylation, positive regulation of transcription factor activity, response to denervation involved in regulation of muscle adaptation, inflammatory response, histone H3 deacetylation, response to interleukin-1, chromatin remodeling, cardiac muscle hypertrophy in response to stress, negative regulation of glycolysis, positive regulation of protein sumoylation, peptidyl-lysine deacetylation, regulation of protein binding
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	246	KDDFPLRKTASEPNLKLRSRL	-	10958686	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.64	-	low
S	246	KDDFPLRKTASEPNLKLRSRL	-	10869435	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.64	-	low
S	467	RQHRPLGRTQSAPLPQNAQAL	CaM-KIV	11470791	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.84	-	low
S	467	RQHRPLGRTQSAPLPQNAQAL	-	18669648	HTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.84	-	low
S	632	GGHRPLSRAQSSPASATFPVS	CaM-KIV	11470791	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.67	-	low
S	632	GGHRPLSRAQSSPASATFPVS	-	18669648	HTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.67	-	low

Substrate:	Raf1 (RAF proto-oncogene serine/threonine-protein kinase)
Seq-ID:	P04049 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-19324   KPYM_HUMAN MINT-24923   RAP1A_HUMAN MINT-45800   1433Z_HUMAN MINT-51053   K1C19_HUMAN MINT-51055   K1C18_HUMAN MINT-51056   K2C8_HUMAN MINT-56513   CNKR1_HUMAN MINT-3389399   PAK1_HUMAN MINT-3389607   PEBP1_HUMAN MINT-3975386   1433S_HUMAN MINT-6946517   RASH_HUMAN MINT-7014370   MP2K1_HUMAN MINT-7014449   AKT1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process protein serine/threonine kinase activity, metal ion binding, receptor signaling protein activity, ATP binding, protein binding plasma membrane, cytosol, mitochondrial outer membrane protein amino acid phosphorylation, negative regulation of cell proliferation, apoptosis, Ras protein signal transduction, cell proliferation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	259	GSLSQRQRSTSTPNVHMVSTT	PKA_group	11971957	LTP	1.00	MOD_PKB_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.73	-	medium
S	259	GSLSQRQRSTSTPNVHMVSTT	PKB_group	10576742	LTP	1.00	MOD_PKB_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.73	-	medium
S	259	GSLSQRQRSTSTPNVHMVSTT	-	12801936	LTP	1.00	MOD_PKB_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.73	-	medium
S	259	GSLSQRQRSTSTPNVHMVSTT	-	18220336	HTP	1.00	MOD_PKB_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.73	-	medium
S	259	GSLSQRQRSTSTPNVHMVSTT	-	18669648	HTP	1.00	MOD_PKB_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.73	-	medium
S	621	HSLPKINRSASEPSLHRAAHT	PKA_group	11971957	LTP	0.99		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.49	-	medium
S	621	HSLPKINRSASEPSLHRAAHT	-	9091312	LTP	0.99		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.49	-	medium

Substrate:	HDAC7A (Enzyme: Deacetylase)
Seq-ID:	Q8WUI4 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-3296507   1433Z_HUMAN MINT-3975829   1433S_HUMAN MINT-6177417   KPCD2_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process protein kinase C binding, transcription repressor binding, histone deacetylase activity histone deacetylase complex, cytoplasm negative regulation of interleukin-2 production, chromatin modification, transcription, positive regulation of cell migration involved in sprouting angiogenesis, negative regulation of osteoblast differentiation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	155	PEHFPLRKTVSEPNLKLRYKP	PKD1	15623513	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.63	-	medium
S	155	PEHFPLRKTVSEPNLKLRYKP	MARK_group	16980613	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.63	-	medium
S	155	PEHFPLRKTVSEPNLKLRYKP	PKD1	18617643	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.63	-	medium
S	155	PEHFPLRKTVSEPNLKLRYKP	PKD1	18509061	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.63	-	medium

Substrate:	Integrin beta 2 (Adhesion molecule)
Seq-ID:	P05107 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-16748   CSN3_HUMAN MINT-45894   SHC1_MOUSE MINT-45897   EPS8_HUMAN MINT-45904   RBGP1_HUMAN MINT-45912   GULP1_HUMAN MINT-45917   NUMB_MOUSE MINT-45924   DAB1_MOUSE MINT-45938   IRS1_RAT MINT-45944   DOK1_MOUSE MINT-45953   TLN1_MOUSE MINT-45956   JIP1_HUMAN MINT-50069   RANB9_HUMAN MINT-4652127   RADI_HUMAN MINT-4652150   CYH1_HUMAN MINT-7226098   ABL1_HUMAN MINT-7226365   TLN2_HUMAN MINT-7226634   VAV_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process receptor activity, protein kinase binding, glycoprotein binding integrin complex apoptosis, integrin-mediated signaling pathway, regulation of cell shape, inflammatory response, cell-cell signaling, neutrophil chemotaxis, cell-matrix adhesion, regulation of peptidyl-tyrosine phosphorylation, leukocyte cell-cell adhesion
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	758	NNDNPLFKSATTTVMNPKFAE	PKC_group	11700305	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Integrin_b_cyt	0.35	2JF1	93.15%
T	758	NNDNPLFKSATTTVMNPKFAE	PKC_alpha	11700305	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Integrin_b_cyt	0.35	2JF1	93.15%
T	758	NNDNPLFKSATTTVMNPKFAE	PKC_delta	11700305	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Integrin_b_cyt	0.35	2JF1	93.15%
T	758	NNDNPLFKSATTTVMNPKFAE	PKC_eta	11700305	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Integrin_b_cyt	0.35	2JF1	93.15%
T	758	NNDNPLFKSATTTVMNPKFAE	-	12682249	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Integrin_b_cyt	0.35	2JF1	93.15%

Substrate:	RIN1 (Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation)
Seq-ID:	Q13671 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-13962   1433B_HUMAN MINT-17571   1433Z_HUMAN MINT-59456   ABL1_MOUSE MINT-59459   ABL2_HUMAN MINT-59464   RASH_HUMAN MINT-59466   ABL1_HUMAN MINT-74713   ERBB2_HUMAN MINT-74714   ERBB3_HUMAN MINT-7972262   DLG4_RAT
GO-Terms:	[show] Molecular Function Cellular Component Biological Process GTPase activator activity, protein binding plasma membrane, cytoplasm, cytoskeleton signal transduction, endocytosis
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	351	GRRRPLLRSMSAAFCSLLAPE	PKD1	11784866	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.38	-	low
S	351	GRRRPLLRSMSAAFCSLLAPE	-	18669648	HTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.38	-	low

Substrate:	Cytokeratin 18 (Structural protein)
Seq-ID:	P05783 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-51052   1433Z_HUMAN MINT-51055   RAF1_HUMAN MINT-61557   GRB2_HUMAN MINT-67331   EXOC8_HUMAN MINT-68023   HGS_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process structural molecule activity, protein binding centriolar satellite, keratin filament, perinuclear region of cytoplasm negative regulation of apoptosis, anatomical structure morphogenesis, cell cycle, interspecies interaction between organisms, Golgi to plasma membrane CFTR protein transport
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	34	YGARPVSSAASVYAGAGGSGS	-	9524113	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.45	-	low
S	34	YGARPVSSAASVYAGAGGSGS	-	16083285	HTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.45	-	low

Substrate:	BAD (Bcl2-antagonist of cell death (BAD) (Bcl-2 binding component 6) (Bcl- XL/Bcl-2 associated death promoter) (Bcl-2-like 8 protein))
Seq-ID:	Q61337 [Mus musculus]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process cytosol, mitochondrial outer membrane induction of apoptosis by extracellular signals, glucose homeostasis, cytokine-mediated signaling pathway, apoptosis, positive regulation of B cell differentiation, positive regulation of T cell differentiation, glucose catabolic process, cell proliferation, regulation of caspase activity
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	112	GAMETRSRHSSYPAGTEEDEG	PKB_group	9381178	LTP	1.00	MOD_PKB_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Bcl-2_BAD	0.88	-	medium
S	112	GAMETRSRHSSYPAGTEEDEG	PKB_group	10949026	LTP	1.00	MOD_PKB_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Bcl-2_BAD	0.88	-	medium
S	112	GAMETRSRHSSYPAGTEEDEG	-	15849194	LTP	1.00	MOD_PKB_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Bcl-2_BAD	0.88	-	medium
S	112	GAMETRSRHSSYPAGTEEDEG	RSK_group	10880354	LTP	1.00	MOD_PKB_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Bcl-2_BAD	0.88	-	medium
S	112	GAMETRSRHSSYPAGTEEDEG	-	17242355	HTP	1.00	MOD_PKB_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Bcl-2_BAD	0.88	-	medium
S	112	GAMETRSRHSSYPAGTEEDEG	RSK_group	16103085	LTP	1.00	MOD_PKB_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Bcl-2_BAD	0.88	-	medium
S	112	GAMETRSRHSSYPAGTEEDEG	PKB_group	11983683	LTP	1.00	MOD_PKB_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Bcl-2_BAD	0.88	-	medium
S	136	ELSPFRGRSRSAPPNLWAAQR	PKB_group	9381178	LTP	1.00	MOD_PKB_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Bcl-2_BAD	0.66	-	medium
S	136	ELSPFRGRSRSAPPNLWAAQR	PKB_group	10949026	LTP	1.00	MOD_PKB_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Bcl-2_BAD	0.66	-	medium

Substrate:	Pde3a (Enzyme Pphosphodiesterase)
Seq-ID:	Q14432 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	MINT-3295899   1433Z_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process metal ion binding, cGMP-inhibited cyclic-nucleotide phosphodiesterase activity integral to membrane lipid metabolic process, signal transduction
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	428	KLAIPKRLRRSLPPGLLRRVS	-	16964243	HTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.49	-	medium
S	428	KLAIPKRLRRSLPPGLLRRVS	-	18669648	HTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.49	-	medium

Substrate:	WEE 1 tyrosine kinase (Dual specificity kinase)
Seq-ID:	P30291 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-50988   1433B_HUMAN MINT-3295375   1433Z_HUMAN MINT-3975741   1433S_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process magnesium ion binding, protein serine/threonine kinase activity, non-membrane spanning protein tyrosine kinase activity, ATP binding, protein binding nucleoplasm protein amino acid phosphorylation, cell division, mitosis
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	642	LIGKKMNRSVSLTIY	-	15150265	LTP	0.98		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.28	-	medium
S	642	LIGKKMNRSVSLTIY	-	15964826	LTP	0.98		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.28	-	medium

Substrate:	Fam64a (Unclassified)
Seq-ID:	Q9BSJ6 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process protein binding nucleolus
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	16	QNMGTSVRRRSLQHQEQLEDS	-	18669648	HTP	-		YWHAE 14-3-3	DUF1466	0.62	-	medium

Substrate:	Potassium voltage-gated channel subfamily H member 2 (potassium ion transport)
Seq-ID:	Q12809 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process delayed rectifier potassium channel activity, two-component sensor activity voltage-gated potassium channel complex muscle contraction, blood circulation, regulation of heart contraction, two-component signal transduction system (phosphorelay), regulation of transcription, DNA-dependent
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	283	RESCASVRRASSADDIEAMRA	PKA_group	11953308	LTP	0.80	MOD_PKA_1	YWHAE 14-3-3	-	0.55	-	low
S	1137	LPQEGPTRRLSLPGQLGALTS	PKA_group	11953308	LTP	1.00	MOD_PKA_1	YWHAE 14-3-3	-	0.79	-	low
S	1137	LPQEGPTRRLSLPGQLGALTS	-	10837251	LTP	1.00	MOD_PKA_1	YWHAE 14-3-3	-	0.79	-	low

Substrate:	SLP-76 (Adaptor molecule; involved in T cell AG receptor mediate signaling)
Seq-ID:	Q13094 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-15244   FYB_HUMAN MINT-16513   SHC1_HUMAN MINT-16846   CBL_HUMAN MINT-17488   FCGR1_HUMAN MINT-59471   ITK_MOUSE MINT-59473   ITK_HUMAN MINT-59474   LCK_HUMAN MINT-2837400   PLCG1_BOVIN MINT-4302560   STAM1_HUMAN MINT-4302608   STAM2_HUMAN MINT-7041321   GRAP2_HUMAN MINT-7306527   NCK1_HUMAN MINT-7306585   SRC_CHICK MINT-7306598   SRC_HUMAN MINT-7306611   FYN_HUMAN MINT-7306624   P85A_HUMAN MINT-7306637   PLCG1_HUMAN MINT-7306657   GRB2_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process protein binding cytosol immune response, transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	376	ESNSSFPQSASLPPYFSQGPS	MAP4K1	17353368	LTP	0.17		YWHAE 14-3-3	-	0.74	-	medium

Substrate:	cdc25c (M-phase inducer phosphatase 3)
Seq-ID:	P30307 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-16690   PLK1_HUMAN MINT-3294433   1433Z_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process protein tyrosine phosphatase activity, WW domain binding cytosol, nucleoplasm regulation of cyclin-dependent protein kinase activity, cell division, traversing start control point of mitotic cell cycle, protein amino acid dephosphorylation, regulation of mitosis, mitosis, interspecies interaction between organisms, DNA replication, cell proliferation
Conservation:
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Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	216	VSRSGLYRSPSMPENLNRPRL	CHK2	10744722	LTP	0.98		CDC25C 14-3-3; NPHP1 14-3-3; SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	M-inducer_phosp	0.66	-	low
S	216	VSRSGLYRSPSMPENLNRPRL	-	15629715	LTP	0.98		CDC25C 14-3-3; NPHP1 14-3-3; SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	M-inducer_phosp	0.66	-	low
S	216	VSRSGLYRSPSMPENLNRPRL	CHK2	9836640	LTP	0.98		CDC25C 14-3-3; NPHP1 14-3-3; SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	M-inducer_phosp	0.66	-	low
S	216	VSRSGLYRSPSMPENLNRPRL	BRSK1	9543386	LTP	0.98		CDC25C 14-3-3; NPHP1 14-3-3; SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	M-inducer_phosp	0.66	-	low

Substrate:	hnRNP C1 / hnRNP C2 (RNA binding protein)
Seq-ID:	P07910 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-48755   NFKB2_HUMAN MINT-49448   TNR1B_HUMAN MINT-66691   RBM41_HUMAN MINT-67437   FXR2_HUMAN MINT-67442   KPBB_HUMAN MINT-67692   PIN1_HUMAN MINT-67973   AP1M1_HUMAN MINT-3296904   1433Z_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process nucleotide binding, identical protein binding, RNA binding spliceosomal complex nuclear mRNA splicing, via spliceosome
Conservation:
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Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	240	NDKSEEEQSSSSVKKDETNVK	-	17287340	HTP	0.40		YWHAE 14-3-3	-	0.87	-	low
S	240	NDKSEEEQSSSSVKKDETNVK	-	18669648	HTP	0.40		YWHAE 14-3-3	-	0.87	-	low

Substrate:	PCTAIRE1 (Serine/threonine-protein kinase PCTAIRE-1)
Seq-ID:	Q00536 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process cyclin-dependent protein kinase activity, ATP binding, protein binding protein amino acid phosphorylation
Conservation:
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Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	119	ISTEDINKRLSLPADIRLPEG	PKA_group	12154078	LTP	0.96	MOD_PKA_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.47	-	medium
S	119	ISTEDINKRLSLPADIRLPEG	-	17192257	HTP	0.96	MOD_PKA_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.47	-	medium
S	153	KPLSRRLRRVSLSEIGFGKLE	PKA_group	12154078	LTP	0.96	MOD_PKA_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.23	-	medium
S	153	KPLSRRLRRVSLSEIGFGKLE	-	17192257	HTP	0.96	MOD_PKA_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.23	-	medium
S	153	KPLSRRLRRVSLSEIGFGKLE	-	18669648	HTP	0.96	MOD_PKA_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.23	-	medium

Substrate:	Orphan nuclear receptor NR4A1 (Orphan nuclear receptor HMR (Early response protein NAK1) (TR3 orphan receptor))
Seq-ID:	P12813 [Mus musculus]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process sequence-specific DNA binding, protein heterodimerization activity, protein homodimerization activity, transcription activator activity, zinc ion binding, sequence-specific DNA binding transcription factor activity, steroid hormone receptor activity nucleus transcription, negative regulation of caspase activity, induction of apoptosis, positive regulation of transcription from RNA polymerase II promoter
Conservation:
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Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	354	SLKGRRGRLPSKPKQPPDASP	-	9322922	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.77	1CIT	100.82%

Substrate:	p53 (Cellular tumor antigen p53)
Seq-ID:	P04637 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-13742   CHK2_HUMAN MINT-15878   UBP7_HUMAN MINT-16161   BRCA1_HUMAN MINT-16977   PARP1_HUMAN MINT-19990   PIN1_HUMAN MINT-24859   ASPP2_HUMAN MINT-45889   CEBPZ_HUMAN MINT-49767   ATM_HUMAN MINT-50577   SAE1_HUMAN MINT-56524   SP1_HUMAN MINT-58470   MED1_HUMAN MINT-58672   HNRL1_HUMAN MINT-60094   HIPK2_HUMAN MINT-61312   MK08_HUMAN MINT-61317   WWOX_HUMAN MINT-62206   PP1A_HUMAN MINT-63290   ARI2_HUMAN MINT-63365   KITH_HUMAN MINT-63497   ZNF24_HUMAN MINT-63537   IF2B_HUMAN MINT-63547   RAB4A_HUMAN MINT-63559   SAT1_HUMAN MINT-64119   STX5_HUMAN MINT-64188   MD2BP_HUMAN MINT-64748   K0087_HUMAN MINT-65132   HSPB1_HUMAN MINT-65272   MPH6_HUMAN MINT-68565   BMX_HUMAN MINT-74886   NPM_HUMAN MINT-74925   1433Z_HUMAN MINT-1795431   NMT1_HUMAN MINT-1891378   CDN1A_HUMAN MINT-1958329   CHK1_HUMAN MINT-2634790   RGRF1_HUMAN MINT-2858243   DVL2_HUMAN MINT-2866927   SCAM1_HUMAN MINT-3390028   KC1D_RAT MINT-3979604   P53_MOUSE MINT-4049689   NR4A1_HUMAN MINT-4052116   SYVN1_HUMAN MINT-4052873   GRP78_HUMAN MINT-4302642   HS71L_HUMAN MINT-4303978   XPO1_HUMAN MINT-4329805   TOPRS_HUMAN MINT-4793180   EGR1_HUMAN MINT-4793253   GSK3B_HUMAN MINT-4793489   PML_HUMAN MINT-5114724   ZN363_HUMAN MINT-5207405   HDAC8_HUMAN MINT-6540866   PSME3_HUMAN MINT-6540889   MDM2_HUMAN MINT-6628692   LT_SV40 MINT-6665320   CBP_HUMAN MINT-6701342   MAP1B_HUMAN MINT-7013631   PA1_HUMAN MINT-7013916   RYBP_HUMAN MINT-7103733   ANDR_HUMAN MINT-7144912   TOE1_HUMAN MINT-7222784   FRAP_HUMAN MINT-7263630   EP300_HUMAN MINT-7266250   PLK1_HUMAN MINT-7294020   FAK1_HUMAN MINT-7295816   IKKB_HUMAN MINT-7557644   GRP75_HUMAN MINT-7711943   1433S_HUMAN MINT-7717378   PHB_HUMAN MINT-7718917   SNAI1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process transcription activator activity, protease binding, DNA strand annealing activity, chromatin binding, copper ion binding, ATP binding, transcription factor binding, chaperone binding, zinc ion binding, histone acetyltransferase binding, promoter binding, sequence-specific DNA binding transcription factor activity, protein N-terminus binding, protein heterodimerization activity, protein phosphatase 2A binding, protein kinase binding, ubiquitin protein ligase binding nucleolus, nuclear matrix, insoluble fraction, protein complex, endoplasmic reticulum, PML body, mitochondrion positive regulation of gene-specific transcription from RNA polymerase II promoter, senescence, mitotic cell cycle G1/S DNA damage checkpoint, cell cycle arrest, regulation of mitochondrial membrane permeability, response to gamma radiation, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, response to tumor cell, ER overload response, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, interspecies interaction between organisms, Ras protein signal transduction, nucleotide-excision repair, protein tetramerization, cellular response to glucose starvation, negative regulation of helicase activity, negative regulation of cell growth, base-excision repair, activation of caspase activity by cytochrome c, cell aging
Conservation:
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Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	376	SSHLKSKKGQSTSRHKKLMFK	CDK7	9315650	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.81	-	-
S	378	HLKSKKGQSTSRHKKLMFKTE	CDK7	9315650	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.82	-	-

Substrate:	Kinase suppressor of ras-1 (ATP binding)
Seq-ID:	Q61097 [Mus musculus]
Download:	fasta csv
Interaction Network(s):	-
External Source(s):
MINT Interaction(s):	[show] MINT-13707   1433B_HUMAN MINT-13837   CDC37_HUMAN MINT-14037   HS90B_HUMAN MINT-16002   MP2K1_HUMAN MINT-17370   HSP71_HUMAN MINT-17529   MP2K2_HUMAN MINT-17608   MK03_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process protein serine/threonine kinase activity, metal ion binding, ATP binding, protein binding cytoplasm, membrane protein amino acid phosphorylation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	297	PSFPTLTRSKSHESQLGNRID	-	9858547	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.59	-	medium
S	392	LPLARLRRTESVPSDINNPVD	-	9858547	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.61	-	medium
S	392	LPLARLRRTESVPSDINNPVD	-	12105213	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.61	-	medium