List of substrates found:


Substrate: Abl (Proto-oncogene tyrosine-protein kinase ABL1)
Seq-ID: P00519 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16419   WASF1_HUMAN
MINT-50717   CBL_HUMAN
MINT-59466   RIN1_HUMAN
MINT-74427   EGFR_HUMAN
MINT-74429   ERBB2_HUMAN
MINT-74430   ERBB3_HUMAN
MINT-74431   ERBB4_HUMAN
MINT-1955124   KPCD_HUMAN
MINT-1955144   B2CL1_HUMAN
MINT-2831131   EP300_HUMAN
MINT-2880967   MUC1_HUMAN
MINT-3390302   ABI2_HUMAN
MINT-4508216   CTNB1_HUMAN
MINT-6787710   PTN1_HUMAN
MINT-7034009   RAD51_HUMAN
MINT-7046591   SHB_HUMAN
MINT-7213827   PRDX1_HUMAN
MINT-7213847   BRCA1_HUMAN
MINT-7214943   M4K1_MOUSE
MINT-7218198   ADA15_HUMAN
MINT-7226098   ITB2_HUMAN
MINT-7226309   TLN2_HUMAN
MINT-7226674   VAV_HUMAN
MINT-7232904   HCK_HUMAN
MINT-7243294   TRI39_HUMAN
MINT-7243330   RPP38_HUMAN
MINT-7243390   HCN2_HUMAN
MINT-7243438   NFASC_HUMAN
MINT-7243462   CENPA_HUMAN
MINT-7243522   DYN2_HUMAN
MINT-7243582   DDX41_HUMAN
MINT-7243594   TGON2_HUMAN
MINT-7243606   SF3B4_HUMAN
MINT-7243630   AKAP6_HUMAN
MINT-7243654   BAZ2A_HUMAN
MINT-7243690   ORC1_HUMAN
MINT-7243726   MLL4_HUMAN
MINT-7243738   BRCA2_HUMAN
MINT-7243798   DPOD1_HUMAN
MINT-7243810   CELR3_HUMAN
MINT-7243846   SUV92_HUMAN
MINT-7243858   KI67_HUMAN
MINT-7243870   FLNC_HUMAN
MINT-7243882   CDKL5_HUMAN
MINT-7243894   CKAP5_HUMAN
MINT-7243906   PRIC3_HUMAN
MINT-7243954   SNX8_HUMAN
MINT-7243966   EPS15_HUMAN
MINT-7243978   VP13A_HUMAN
MINT-7243990   SNX12_HUMAN
MINT-7244002   SNX17_HUMAN
MINT-7244026   CDC27_HUMAN
MINT-7244086   SPN90_HUMAN
MINT-7244098   LRBA_HUMAN
MINT-7244134   CTGE5_HUMAN
MINT-7244146   ICAL_HUMAN
MINT-7244182   FETUA_HUMAN
MINT-7244194   WNK2_HUMAN
MINT-7244206   RPGF1_HUMAN
MINT-7244230   CD2AP_HUMAN
MINT-7244302   ARHGB_HUMAN
MINT-7244314   SP1_HUMAN
MINT-7244350   OSBL5_HUMAN
MINT-7244362   RTN4_HUMAN
MINT-7244374   MED14_HUMAN
MINT-7244446   SYNJ2_HUMAN
MINT-7244482   ACAP1_HUMAN
MINT-7244494   NELFB_HUMAN
MINT-7244542   LAP2B_HUMAN
MINT-7244554   P2RX7_HUMAN
MINT-7244566   FYB_HUMAN
MINT-7244602   E41L3_HUMAN
MINT-7244614   SNX3_HUMAN
MINT-7244626   GT2D1_HUMAN
MINT-7244638   DYN1_HUMAN
MINT-7244650   ASAP1_HUMAN
MINT-7244662   G3BP2_HUMAN
MINT-7244674   DNLI3_HUMAN
MINT-7244698   DLGP4_HUMAN
MINT-7244746   BRPF3_HUMAN
MINT-7244806   M4K1_HUMAN
MINT-7244830   CUL7_HUMAN
MINT-7244866   FLNA_HUMAN
MINT-7244878   RIMS1_HUMAN
MINT-7245034   SRC_HUMAN
MINT-7246522   FYN_HUMAN
MINT-7249642   NCK1_HUMAN
MINT-7251418   P85A_HUMAN
MINT-7252738   PLCG1_HUMAN
MINT-7253218   GRB2_HUMAN
MINT-7254106   CRK_HUMAN
MINT-7297574   MAVS_HUMAN
MINT-7301011   TOP1_HUMAN
MINT-7309761   P73_HUMAN
MINT-7385614   3BP1_MOUSE
MINT-7385781   ABI1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
magnesium ion binding,
manganese ion binding,
DNA binding,
protein C-terminus binding,
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
proline-rich region binding		 cytosol,
nuclear membrane,
cytoskeleton,
nucleolus,
perinuclear region of cytoplasm		 regulation of transcription involved in S phase of mitotic cell cycle,
mismatch repair,
actin cytoskeleton organization,
signal transduction,
cell adhesion,
peptidyl-tyrosine phosphorylation,
positive regulation of oxidoreductase activity,
DNA damage response, signal transduction resulting in induction of apoptosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 446 GMSPYPGIDLSQVYELLEKDY ATM 9168116
LTP
0.87
 MOD_PIKK_1
 - TyrKc
0.20
 2HZI 68.03%

Substrate: ATM (Serine/threonine kinase)
Seq-ID: Q13315 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-49767   P53_HUMAN
MINT-2843419   H2AX_HUMAN
MINT-6978609   NEMO_HUMAN
MINT-7543535   TYDP1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein dimerization activity,
1-phosphatidylinositol-3-kinase activity,
DNA binding,
identical protein binding,
ATP binding,
DNA-dependent protein kinase activity,
protein N-terminus binding,
protein complex binding		 cytoplasmic membrane-bounded vesicle,
nucleoplasm		 senescence,
DNA repair,
reciprocal meiotic recombination,
positive regulation of DNA damage response, signal transduction by p53 class mediator,
cell cycle arrest,
pre-B cell allelic exclusion,
cellular response to gamma radiation,
G2/M transition DNA damage checkpoint,
protein amino acid autophosphorylation,
mitotic cell cycle spindle assembly checkpoint,
histone mRNA catabolic process,
DNA damage induced protein phosphorylation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 1981 EKRSLAFEEGSQSTTISSLSE ATM 12556884
LTP
1.00
 MOD_PIKK_1
 - -
0.44
 - low

Substrate: Bloom syndrome protein (Enzyme: DNA helicase)
Seq-ID: P54132 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
G-quadruplex DNA binding,
ATP-dependent 3`-5` DNA helicase activity,
DNA strand annealing activity,
p53 binding,
ATP binding,
bubble DNA binding,
four-way junction helicase activity		 cytoplasm,
lateral element,
nucleolus,
nuclear matrix,
PML body		 replication fork processing,
G2 phase of mitotic cell cycle,
positive regulation of transcription,
regulation of cyclin-dependent protein kinase activity,
replication fork protection,
G2/M transition DNA damage checkpoint,
protein oligomerization,
response to X-ray,
double-strand break repair via homologous recombination,
negative regulation of cell division
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 99 FFKNAPAGQETQRGGSKSLLP ATM 11375976
LTP
0.10
 MOD_PIKK_1
 - -
0.63
 - medium

Substrate: BRCA1 (Breast cancer type 1 susceptibility protein)
Seq-ID: P38398 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13705   JAK2_HUMAN
MINT-13786   ESR1_HUMAN
MINT-14573   SMC1A_HUMAN
MINT-16089   BRAP_HUMAN
MINT-16161   P53_HUMAN
MINT-16217   CREB1_HUMAN
MINT-16582   JAK1_HUMAN
MINT-19473   FACD2_HUMAN
MINT-19477   FANCA_HUMAN
MINT-25055   BARD1_HUMAN
MINT-77954   VE7_HPV16
MINT-2490745   H4_HUMAN
MINT-2791487   RD23B_HUMAN
MINT-5115454   FANCJ_HUMAN
MINT-7213847   ABL1_HUMAN
MINT-7250578   NCK1_HUMAN
MINT-7251658   P85A_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA binding,
identical protein binding,
ubiquitin protein ligase binding,
androgen receptor binding,
RNA binding,
transcription coactivator activity,
zinc ion binding,
tubulin binding,
ubiquitin-protein ligase activity		 ribonucleoprotein complex,
gamma-tubulin ring complex,
nucleoplasm,
BRCA1-BARD1 complex,
BRCA1-A complex		 positive regulation of gene-specific transcription from RNA polymerase II promoter,
negative regulation of centriole replication,
response to estrogen stimulus,
apoptosis,
chromosome segregation,
cellular response to indole-3-methanol,
fatty acid biosynthetic process,
regulation of transcription from RNA polymerase III promoter,
cell cycle,
postreplication repair,
G2/M transition DNA damage checkpoint,
positive regulation of protein ubiquitination,
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator,
negative regulation of transcription,
positive regulation of DNA repair,
negative regulation of fatty acid biosynthetic process,
androgen receptor signaling pathway,
regulation of cell proliferation,
protein K6-linked ubiquitination,
DNA damage response, signal transduction resulting in induction of apoptosis,
double-strand break repair via homologous recombination,
response to ionizing radiation,
protein autoubiquitination
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 1330 SSKQMRHQSESQGVGLSDKEL ATM 10550055
LTP
0.35
 MOD_PIKK_1
 - -
0.71
 --
S 1387 SVSEDCSGLSSQSDILTTQQR ATM 12183412
LTP
1.00
 MOD_PIKK_1
 - -
0.67
 --
S 1423 ELEAVLEQHGSQPSNSYPSII ATM 10550055
LTP
1.00
 MOD_PIKK_1
 - COIL
0.74
 --
S 1423 ELEAVLEQHGSQPSNSYPSII ATM 11278964
LTP
1.00
 MOD_PIKK_1
 - COIL
0.74
 --
S 1457 QSTSEKAVLTSQKSSEYPISQ ATM 10550055
LTP
1.00
 MOD_PIKK_1
 - -
0.74
 --
S 1457 QSTSEKAVLTSQKSSEYPISQ ATM 11278964
LTP
1.00
 MOD_PIKK_1
 - -
0.74
 --
S 1466 TSQKSSEYPISQNPEGLSADK ATM 10550055
LTP
0.91
 MOD_PIKK_1
 - -
0.70
 --
S 1497 KNKEPGVERSSPSKCPSLDDR ATM 10550055
LTP
1.00
 MOD_CDK_SPxK_1
 - -
0.76
 --
S 1524 SGSLQNRNYPSQEELIKVVDV ATM 10550055
LTP
1.00
 MOD_PIKK_1
 - -
0.62
 --
S 1524 SGSLQNRNYPSQEELIKVVDV ATM 11278964
LTP
1.00
 MOD_PIKK_1
 - -
0.62
 --

Substrate: CHK1 (Serine/threonine-protein kinase Chk1)
Seq-ID: O14757 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-51394   CSK2B_HUMAN
MINT-1958329   P53_HUMAN
MINT-4793746   RB_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
ATP binding,
protein binding		 condensed nuclear chromosome,
microtubule organizing center,
nucleoplasm		 protein amino acid phosphorylation,
regulation of cyclin-dependent protein kinase activity,
senescence,
DNA repair,
reciprocal meiotic recombination,
negative regulation of cell proliferation,
DNA damage checkpoint,
gamete generation,
DNA replication
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 317 SSEENVKYSSSQPEPRTGLSL ATM 11252893
LTP
0.96
 MOD_PIKK_1
 - -
0.56
 --
S 345 IDKLVQGISFSQPTCPDHMLL ATM 15533933
LTP
1.00
 MOD_PIKK_1
 SFN 14-3-3;
YWHAZ 14-3-3		 -
0.30
 --

Substrate: CHK2 (Serine/threonine-protein kinase Chk2)
Seq-ID: O96017 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13742   P53_HUMAN
MINT-15591   MPIP1_HUMAN
MINT-49652   NBN_HUMAN
MINT-58599   MDM2_HUMAN
MINT-62311   IMA2_HUMAN
MINT-4793727   RB_HUMAN
MINT-6806274   STRAP_HUMAN
MINT-7294980   XRCC1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
metal ion binding,
ATP binding,
protein binding		 PML body protein amino acid phosphorylation,
senescence,
cell cycle,
DNA damage checkpoint,
DNA damage response, signal transduction resulting in induction of apoptosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 19 AQQSHGSSACSQPHGSVTQSQ ATM 10973490
LTP
0.75
 MOD_PIKK_1
 - -
0.81
 --
T 26 SACSQPHGSVTQSQGSSSQSQ ATM 10973490
LTP
0.82
 MOD_PIKK_1
 - -
0.79
 --
S 28 CSQPHGSVTQSQGSSSQSQGI ATM 10973490
LTP
0.02
 MOD_PIKK_1
 - -
0.80
 --
S 33 GSVTQSQGSSSQSQGISSSST ATM 10973490
LTP
0.05
 MOD_PIKK_1
 - -
0.80
 --
S 35 VTQSQGSSSQSQGISSSSTST ATM 10973490
LTP
0.00
 MOD_PIKK_1
 - -
0.80
 --
S 50 SSSTSTMPNSSQSSHSSSGTL ATM 10973490
LTP
1.00
 MOD_PIKK_1
 - -
0.77
 --
T 68 GTLSSLETVSTQELYSIPEDQ ATM 10973490
LTP
0.08
 MOD_PIKK_1
 MDC1 FHA;
PLK1 PBD		 -
0.61
 --

Substrate: CREB (cAMP response element binding protein (CREB).)
Seq-ID: P16220 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-16217   BRCA1_HUMAN
MINT-56642   SGK1_HUMAN
MINT-63231   RECQ5_HUMAN
MINT-63483   VIME_HUMAN
MINT-63485   CHD3_HUMAN
MINT-4979977   CBP_HUMAN
MINT-5209851   EP300_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein dimerization activity,
transcription cofactor activity		 protein amino acid phosphorylation,
signal transduction,
interspecies interaction between organisms,
response to organic substance
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 111 QISTIAESEDSQESVDSVTDS ATM 15073328
LTP
1.00
 MOD_PIKK_1
 - -
0.75
 - low
S 121 SQESVDSVTDSQKRREILSRR ATM 15073328
LTP
1.00
 MOD_PIKK_1
 - pKID
0.73
 - low
S 121 SQESVDSVTDSQKRREILSRR ATM 16293623
LTP
1.00
 MOD_PIKK_1
 - pKID
0.73
 - low

Substrate: CtIP (Retinoblastoma-binding protein 8 (RBBP-8) (CtBP interacting protein) (CtIP) (Retinoblastoma-interacting protein and myosin-like) (RIM))
Seq-ID: Q99708 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-14618   CTBP1_HUMAN
MINT-16160   RBL2_HUMAN
MINT-49958   AATF_HUMAN
MINT-67681   FXR2_HUMAN
MINT-67901   PIN1_HUMAN
MINT-68425   RBL1_HUMAN
MINT-6628409   RB_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
single-stranded DNA specific endodeoxyribonuclease activity,
damaged DNA binding,
protein binding		 nucleus regulation of transcription from RNA polymerase II promoter,
DNA double-strand break processing involved in repair via single-strand annealing,
cell cycle checkpoint
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 664 QWSIDPGADLSQYKMDVTVID ATM 10910365
LTP
1.00
 MOD_PIKK_1
 - -
0.44
 - medium
S 745 EYESCLADSFSQAADEEEELS ATM 10910365
LTP
0.49
 MOD_PIKK_1
 - -
0.50
 - medium

Substrate: Cyclic-AMP-dependent transcription factor ATF-2 (Transcription factor)
Seq-ID: P15336 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-1788416   JUNB_HUMAN
MINT-6628041   JUN_HUMAN
MINT-6628046   CITE1_HUMAN
MINT-6699865   I2BP1_HUMAN
MINT-7555703   HDAC4_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
sequence-specific DNA binding,
protein dimerization activity,
RNA polymerase II transcription factor activity,
transcription coactivator activity,
zinc ion binding,
sequence-specific DNA binding transcription factor activity		 nucleoplasm transcription,
regulation of transcription, DNA-dependent
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 472 MADQSTEPALSQIVMAPSSQS ATM 15916964
LTP
0.00
 MOD_PIKK_1
 - -
0.76
 --
S 480 ALSQIVMAPSSQSQPSGS    ATM 15916964
LTP
0.00
 MOD_PIKK_1
 - -
0.76
 --

Substrate: DNA ligase IV (DNA ligase IV)
Seq-ID: P49917 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA binding,
protein C-terminus binding,
metal ion binding,
ATP binding,
DNA ligase (ATP) activity		 condensed chromosome,
DNA-dependent protein kinase-DNA ligase 4 complex,
DNA ligase IV complex		 chromosome organization,
central nervous system development,
cell division,
positive regulation of neurogenesis,
isotype switching,
DNA ligation involved in DNA recombination,
cell cycle,
T cell receptor V(D)J recombination,
in utero embryonic development,
response to gamma radiation,
response to X-ray,
nucleotide-excision repair, DNA gap filling,
neuron apoptosis,
initiation of viral infection,
negative regulation of neuron apoptosis,
somatic stem cell maintenance,
DNA replication,
T cell differentiation in the thymus,
single strand break repair,
DNA ligation involved in DNA repair,
cell proliferation,
double-strand break repair via nonhomologous end joining,
positive regulation of fibroblast proliferation,
pro-B cell differentiation,
provirus integration
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 199 MIIKDLKLGVSQQTIFSVFHN ATM 10608806
LTP
1.00
 MOD_PIKK_1
 - DNA_ligase_A_N
0.07
 --

Substrate: Double strand break repair protein MRE11A (Deoxyribonuclease)
Seq-ID: P49959 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-7231003   RAD50_HUMAN
MINT-7906697   FACD2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
manganese ion binding,
single-stranded DNA specific endodeoxyribonuclease activity,
protein C-terminus binding,
3`-5` exonuclease activity,
double-stranded DNA binding		 nucleoplasm,
Mre11 complex		 double-strand break repair via nonhomologous end joining,
reciprocal meiotic recombination,
negative regulation of DNA endoreduplication,
positive regulation of kinase activity,
regulation of mitotic recombination,
DNA duplex unwinding,
telomere maintenance via telomerase,
positive regulation of protein amino acid autophosphorylation,
sister chromatid cohesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 264 TKNEQQLFYISQPGSSVVTSL ATM 10608806
LTP
0.25
 MOD_PIKK_1
 - Mre11_DNA_bind
0.35
 - medium

Substrate: E2F-1 (Transcription factor)
Seq-ID: Q01094 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19370   TOPB1_HUMAN
MINT-73331   VE7_HPV16
MINT-4793665   RB_HUMAN
MINT-6804982   MCPH1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription corepressor activity,
sequence-specific DNA binding transcription factor activity		 mitochondrion transcription,
G1 phase of mitotic cell cycle,
apoptosis,
mRNA stabilization,
negative regulation of transcription from RNA polymerase II promoter,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 31 GAGALRLLDSSQIVIISAAQD ATM 11459832
LTP
0.14
 MOD_PIKK_1
 - -
0.33
 - medium

Substrate: eIF4E-binding protein 1 (Eukaryotic translation initiation factor 4E binding protein 1 (4E-BP1) (eIF4E-binding protein 1) (Phosphorylated heat- and acid-stable protein regulated by insulin 1) (PHAS-I))
Seq-ID: Q13541 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19057   IF4E_HUMAN
MINT-64139   ERG19_HUMAN
MINT-6549354   RPTOR_HUMAN
MINT-7021879   HS90B_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cytosol TOR signaling cascade,
positive regulation of mitotic cell cycle,
G1/S transition of mitotic cell cycle
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 8    MSGGSSCSQTPSRAIPAT ATM 10713094
LTP
0.17
 MOD_PIKK_1
 - eIF_4EBP
0.79
 - medium
S 112 PEDKRAGGEESQFEMDI     ATM 11146653
LTP
0.03
 MOD_PIKK_1
 - eIF_4EBP
0.84
 - medium

Substrate: Fanconi anemia, complementation group D2 (Cell cycle control protein)
Seq-ID: Q9BXW9 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19473   BRCA1_HUMAN
MINT-49427   TNR1B_HUMAN
MINT-5206796   FANCE_HUMAN
MINT-7906555   H2AX_HUMAN
MINT-7906687   NBN_HUMAN
MINT-7906697   MRE11_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein binding nucleoplasm DNA repair,
response to gamma radiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 222 ITSLPEILGDSQHADVGKELS ATM 12086603
HTP
1.00
 MOD_PIKK_1
 - -
0.21
 - low
S 1257 KKIEPGTAADSQQIHEEKLLY ATM 12086603
HTP
0.20
 MOD_PIKK_1
 - -
0.28
 - low

Substrate: Histone H2AFX (Histone H2A)
Seq-ID: P16104 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-56621   WRN_HUMAN
MINT-2843419   ATM_HUMAN
MINT-3378379   TP53B_HUMAN
MINT-7543857   XRCC1_HUMAN
MINT-7543888   TYDP1_HUMAN
MINT-7906555   FACD2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
histone binding,
enzyme binding		 nucleoplasm,
nucleosome		 nucleosome assembly,
cell aging,
DNA damage checkpoint,
positive regulation of DNA repair,
meiosis,
response to ionizing radiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 140 PSGGKKATQASQEY        ATM 11571274
LTP
0.57
 MOD_PIKK_1
 - -
0.66
 - medium

Substrate: Histone H2AFX (Histone H2A)
Seq-ID: P27661 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
damaged DNA binding XY body,
replication fork,
male germ cell nucleus,
nucleosome		 nucleosome assembly,
spermatogenesis,
meiosis,
double-strand break repair via homologous recombination
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 140 PAVGKKASQASQEY        ATM 11571274
LTP
0.30
 MOD_PIKK_1
 - -
0.50
 - medium

Substrate: Mdm2 (Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2. -) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2))
Seq-ID: Q00987 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-16320   ARRB2_HUMAN
MINT-58469   MED1_HUMAN
MINT-58599   CHK2_HUMAN
MINT-68739   HIPK2_HUMAN
MINT-1776635   RB_HUMAN
MINT-3376147   ARBK1_HUMAN
MINT-3391121   RL5_HUMAN
MINT-4793330   PML_HUMAN
MINT-6540837   PSME3_HUMAN
MINT-6540889   P53_HUMAN
MINT-6801697   DAXX_HUMAN
MINT-6823537   AKT1_HUMAN
MINT-6823574   PIM2_HUMAN
MINT-6823669   FKBP3_HUMAN
MINT-7013760   RYBP_HUMAN
MINT-7266353   PLK1_HUMAN
MINT-7718939   SNAI1_HUMAN
MINT-7904837   GORAB_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
identical protein binding,
p53 binding,
enzyme binding,
zinc ion binding,
basal transcription repressor activity,
ubiquitin-protein ligase activity		 plasma membrane,
endocytic vesicle membrane,
cytosol,
nucleolus,
nucleoplasm,
insoluble fraction,
protein complex		 positive regulation of cell proliferation,
protein complex assembly,
protein destabilization,
positive regulation of mitotic cell cycle,
negative regulation of DNA damage response, signal transduction by p53 class mediator,
positive regulation of proteasomal ubiquitin-dependent protein catabolic process,
protein ubiquitination involved in ubiquitin-dependent protein catabolic process,
interspecies interaction between organisms,
negative regulation of cell cycle arrest,
negative regulation of transcription from RNA polymerase II promoter,
protein localization in nucleus,
establishment of protein localization
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 395 ASQSQESEDYSQPSTSSSIIY ATM 11331603
LTP
1.00
 MOD_PIKK_1
 - -
0.62
 - medium

Substrate: NF-kappa-B essential modulator (Serine/threonine kinase)
Seq-ID: Q9Y6K9 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-15857   TNAP3_HUMAN
MINT-16075   RIPK1_HUMAN
MINT-16575   RIPK2_HUMAN
MINT-47843   IKBA_HUMAN
MINT-47855   IKBB_HUMAN
MINT-48127   SYVC_HUMAN
MINT-48129   GOGA3_HUMAN
MINT-48131   HS71L_HUMAN
MINT-48132   GRP78_HUMAN
MINT-48133   DREB_HUMAN
MINT-48134   HSP7C_HUMAN
MINT-48137   IKKA_HUMAN
MINT-48140   ADT2_HUMAN
MINT-48142   GRP75_HUMAN
MINT-48144   SYMC_HUMAN
MINT-48146   RS10_HUMAN
MINT-48147   RLA2_HUMAN
MINT-48149   XPO1_HUMAN
MINT-48151   MYO1C_HUMAN
MINT-48152   EPIPL_HUMAN
MINT-48153   RS3_HUMAN
MINT-48154   TIF1B_HUMAN
MINT-48156   RS20_HUMAN
MINT-48157   KINH_HUMAN
MINT-48158   CDC37_HUMAN
MINT-48159   SYIC_HUMAN
MINT-48160   GBLP_HUMAN
MINT-48161   EF1A2_HUMAN
MINT-48162   MSH2_HUMAN
MINT-48166   MCM7_HUMAN
MINT-48167   MYH10_HUMAN
MINT-48168   PYR1_HUMAN
MINT-48169   CALX_HUMAN
MINT-48170   ACTG_HUMAN
MINT-48171   ESYT1_HUMAN
MINT-48173   CLH1_HUMAN
MINT-48174   IKKB_HUMAN
MINT-48177   RS14_HUMAN
MINT-48181   DYHC1_HUMAN
MINT-48186   CALM_HUMAN
MINT-48187   UTP20_HUMAN
MINT-48188   RLA0_HUMAN
MINT-48190   HS90A_HUMAN
MINT-48192   FAS_HUMAN
MINT-48193   TBB5_HUMAN
MINT-48195   ECM29_HUMAN
MINT-48196   TBB4_HUMAN
MINT-48198   RS27_HUMAN
MINT-48199   A16L1_HUMAN
MINT-48204   KCC2D_HUMAN
MINT-48205   USO1_HUMAN
MINT-48206   1433Z_HUMAN
MINT-48207   FLNA_HUMAN
MINT-48208   IPO7_HUMAN
MINT-48209   SMC4_HUMAN
MINT-48213   GCN1L_HUMAN
MINT-48214   MYH9_HUMAN
MINT-48215   HNRPU_HUMAN
MINT-48218   VIME_HUMAN
MINT-48220   PARP1_HUMAN
MINT-48221   ADT3_HUMAN
MINT-48222   CCAR1_HUMAN
MINT-48223   COPA_HUMAN
MINT-48224   TBK1_HUMAN
MINT-48225   PP1G_HUMAN
MINT-48226   PP1B_HUMAN
MINT-48227   TXLNA_HUMAN
MINT-48228   PUR2_HUMAN
MINT-48229   PRKDC_HUMAN
MINT-48230   MYL6_HUMAN
MINT-48232   XPO7_HUMAN
MINT-48235   RS3A_HUMAN
MINT-48239   HS90B_HUMAN
MINT-48240   ML12A_HUMAN
MINT-48241   CH60_HUMAN
MINT-48244   SET_HUMAN
MINT-48245   MYO1D_HUMAN
MINT-48371   M3K3_HUMAN
MINT-48638   NFKB1_HUMAN
MINT-48692   NFKB2_HUMAN
MINT-48784   M3K14_HUMAN
MINT-2844414   SQSTM_HUMAN
MINT-4652797   M3K7_HUMAN
MINT-6177604   MALT1_HUMAN
MINT-6978609   ATM_HUMAN
MINT-6978686   ATR_HUMAN
MINT-6978719   ATRIP_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein domain specific binding,
metal ion binding,
signal transducer activity		 nucleus transcription,
immune response,
interspecies interaction between organisms,
positive regulation of NF-kappaB transcription factor activity,
response to DNA damage stimulus,
T cell receptor signaling pathway,
induction of apoptosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 85 RCEELLHFQASQREEKEFLMC ATM 16497931
LTP
0.89
 MOD_PIKK_1
 - COIL
0.30
 3BRV 56.56%

Substrate: NFAT5 (Transcription factor)
Seq-ID: O94916 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
RNA polymerase II transcription factor activity,
sequence-specific DNA binding transcription factor activity		 nucleus transcription from RNA polymerase II promoter,
signal transduction,
excretion,
regulation of transcription, DNA-dependent
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 1197 PISHIQTPMLSQEQAQPPQQG ATM 15173573
LTP
0.15
 MOD_PIKK_1
 - -
0.85
 - medium
S 1247 SIVAMQSNSPSQEQQQQQQQQ ATM 15173573
LTP
0.20
 MOD_PIKK_1
 - -
0.89
 - medium
S 1367 QIQLVQGSPSSQEQQVTLFLS ATM 15173573
LTP
0.10
 MOD_PIKK_1
 - -
0.61
 - medium

Substrate: Nibrin (NIBRIN (NIJMEGEN BREAKAGE syndrome protein 1) (Cell cycle regulatory protein P95).)
Seq-ID: O60934 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-49652   CHK2_HUMAN
MINT-6805510   MDC1_HUMAN
MINT-7231018   RAD50_HUMAN
MINT-7906687   FACD2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription factor binding,
protein N-terminus binding		 nucleolus,
Golgi apparatus,
nucleoplasm,
nuclear inclusion body,
Mre11 complex,
nuclear chromosome, telomeric region		 mitotic cell cycle G1/S transition checkpoint,
DNA damage response, signal transduction by p53 class mediator,
positive regulation of kinase activity,
cell cycle arrest,
DNA duplex unwinding,
telomere maintenance,
positive regulation of protein amino acid autophosphorylation,
mitotic cell cycle G2/M transition DNA damage checkpoint,
double-strand break repair,
meiosis,
regulation of DNA-dependent DNA replication initiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 278 TCVVDTGITNSQTLIPDCQKK ATM 10839544
LTP
0.93
 MOD_PIKK_1
 - -
0.37
 - high
S 278 TCVVDTGITNSQTLIPDCQKK ATM 15279770
LTP
0.93
 MOD_PIKK_1
 - -
0.37
 - high
S 343 LKTTTPGPSLSQGVSVDEKLM ATM 10839545
LTP
0.95
 MOD_PIKK_1
 - -
0.69
 - high
S 343 LKTTTPGPSLSQGVSVDEKLM ATM 10839544
LTP
0.95
 MOD_PIKK_1
 - -
0.69
 - high
S 343 LKTTTPGPSLSQGVSVDEKLM ATM 15279770
LTP
0.95
 MOD_PIKK_1
 - -
0.69
 - high
S 397 SKMEQKFRMLSQDAPTVKESC ATM 10839545
LTP
0.14
 MOD_PIKK_1
 - -
0.59
 - high

Substrate: p53 (Cellular tumor antigen p53)
Seq-ID: P04637 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13742   CHK2_HUMAN
MINT-15878   UBP7_HUMAN
MINT-16161   BRCA1_HUMAN
MINT-16977   PARP1_HUMAN
MINT-19990   PIN1_HUMAN
MINT-24859   ASPP2_HUMAN
MINT-45889   CEBPZ_HUMAN
MINT-49767   ATM_HUMAN
MINT-50577   SAE1_HUMAN
MINT-56524   SP1_HUMAN
MINT-58470   MED1_HUMAN
MINT-58672   HNRL1_HUMAN
MINT-60094   HIPK2_HUMAN
MINT-61312   MK08_HUMAN
MINT-61317   WWOX_HUMAN
MINT-62206   PP1A_HUMAN
MINT-63290   ARI2_HUMAN
MINT-63365   KITH_HUMAN
MINT-63497   ZNF24_HUMAN
MINT-63537   IF2B_HUMAN
MINT-63547   RAB4A_HUMAN
MINT-63559   SAT1_HUMAN
MINT-64119   STX5_HUMAN
MINT-64188   MD2BP_HUMAN
MINT-64748   K0087_HUMAN
MINT-65132   HSPB1_HUMAN
MINT-65272   MPH6_HUMAN
MINT-68565   BMX_HUMAN
MINT-74886   NPM_HUMAN
MINT-74925   1433Z_HUMAN
MINT-1795431   NMT1_HUMAN
MINT-1891378   CDN1A_HUMAN
MINT-1958329   CHK1_HUMAN
MINT-2634790   RGRF1_HUMAN
MINT-2858243   DVL2_HUMAN
MINT-2866927   SCAM1_HUMAN
MINT-3390028   KC1D_RAT
MINT-3979604   P53_MOUSE
MINT-4049689   NR4A1_HUMAN
MINT-4052116   SYVN1_HUMAN
MINT-4052873   GRP78_HUMAN
MINT-4302642   HS71L_HUMAN
MINT-4303978   XPO1_HUMAN
MINT-4329805   TOPRS_HUMAN
MINT-4793180   EGR1_HUMAN
MINT-4793253   GSK3B_HUMAN
MINT-4793489   PML_HUMAN
MINT-5114724   ZN363_HUMAN
MINT-5207405   HDAC8_HUMAN
MINT-6540866   PSME3_HUMAN
MINT-6540889   MDM2_HUMAN
MINT-6628692   LT_SV40
MINT-6665320   CBP_HUMAN
MINT-6701342   MAP1B_HUMAN
MINT-7013631   PA1_HUMAN
MINT-7013916   RYBP_HUMAN
MINT-7103733   ANDR_HUMAN
MINT-7144912   TOE1_HUMAN
MINT-7222784   FRAP_HUMAN
MINT-7263630   EP300_HUMAN
MINT-7266250   PLK1_HUMAN
MINT-7294020   FAK1_HUMAN
MINT-7295816   IKKB_HUMAN
MINT-7557644   GRP75_HUMAN
MINT-7711943   1433S_HUMAN
MINT-7717378   PHB_HUMAN
MINT-7718917   SNAI1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription activator activity,
protease binding,
DNA strand annealing activity,
chromatin binding,
copper ion binding,
ATP binding,
transcription factor binding,
chaperone binding,
zinc ion binding,
histone acetyltransferase binding,
promoter binding,
sequence-specific DNA binding transcription factor activity,
protein N-terminus binding,
protein heterodimerization activity,
protein phosphatase 2A binding,
protein kinase binding,
ubiquitin protein ligase binding		 nucleolus,
nuclear matrix,
insoluble fraction,
protein complex,
endoplasmic reticulum,
PML body,
mitochondrion		 positive regulation of gene-specific transcription from RNA polymerase II promoter,
senescence,
mitotic cell cycle G1/S DNA damage checkpoint,
cell cycle arrest,
regulation of mitochondrial membrane permeability,
response to gamma radiation,
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator,
response to tumor cell,
ER overload response,
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis,
interspecies interaction between organisms,
Ras protein signal transduction,
nucleotide-excision repair,
protein tetramerization,
cellular response to glucose starvation,
negative regulation of helicase activity,
negative regulation of cell growth,
base-excision repair,
activation of caspase activity by cytochrome c,
cell aging
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 15 QSDPSVEPPLSQETFSDLWKL ATM 11875057
LTP
1.00
 MOD_PIKK_1
 - P53_TAD
0.73
 --
S 46 PSQAMDDLMLSPDDIEQWFTE ATM 20123963
LTP
0.58
 MAGI1 WW;
PIN1 WW		 -
0.63
 --

Substrate: p53-binding protein 1 (Transcription regulatory protein)
Seq-ID: Q12888 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-2829624   H4_HUMAN
MINT-2830088   H31_HUMAN
MINT-3378379   H2AX_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription activator activity,
protein binding		 condensed chromosome kinetochore,
cytoplasm,
nucleoplasm		 transcription,
DNA repair,
positive regulation of transcription, DNA-dependent
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 6      MDPTGSQLDSDFSQQD ATM 12697768
LTP
1.00
 MOD_PIKK_1
 - -
0.87
 --
S 25 QDTPCLIIEDSQPESQVLEDD ATM 12697768
LTP
1.00
 MOD_PIKK_1
 - -
0.77
 --
S 29 CLIIEDSQPESQVLEDDSGSH ATM 12697768
LTP
1.00
 MOD_PIKK_1
 - -
0.75
 --
S 784 PLEGVEKCSDSQSWEDIAPEI ATM 12697768
LTP
0.22
 MOD_PIKK_1
 - -
0.62
 --

Substrate: Rad17 (hRad17 protein)
Seq-ID: O75943 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
nucleoside-triphosphatase activity,
ATP binding,
protein binding		 cytoplasm,
nucleus		 DNA repair,
regulation of phosphorylation,
cell cycle,
DNA damage checkpoint,
DNA replication checkpoint,
DNA replication,
mitotic cell cycle checkpoint
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 646 TVPETWSLPLSQNSASELPAS ATM 10608806
LTP
1.00
 MOD_PIKK_1
 - -
0.64
 - medium
S 656 SQNSASELPASQPQPFSAQGD ATM 10608806
LTP
1.00
 MOD_PIKK_1
 - -
0.83
 - medium

Substrate: RAD50 (DNA binding protein)
Seq-ID: Q92878 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-7231003   MRE11_HUMAN
MINT-7231018   NBN_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA binding,
nuclease activity,
protein binding, bridging,
ATP binding,
zinc ion binding		 Mre11 complex,
nuclear chromosome, telomeric region		 reciprocal meiotic recombination,
positive regulation of kinase activity,
regulation of mitotic recombination,
DNA duplex unwinding,
telomere maintenance via telomerase,
positive regulation of protein amino acid autophosphorylation,
double-strand break repair
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 635 YEDKLFDVCGSQDFESDLDRL ATM 17570479
LTP
1.00
 MOD_PIKK_1
 - COIL
0.31
 - medium

Substrate: Rad9 (Cell cycle checkpoint control protein (RAD9))
Seq-ID: Q99638 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-3379418   TOPB1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
exodeoxyribonuclease III activity,
protein kinase binding,
3`-5` exonuclease activity,
histone deacetylase binding		 nucleus DNA repair,
DNA damage checkpoint,
DNA replication checkpoint,
DNA replication
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 272 LATLSDTDSHSQDLGSPERHQ ATM 11278446
LTP
0.98
 MOD_PIKK_1
 - -
0.78
 --

Substrate: Replication factor-A protein 2 (DNA binding protein)
Seq-ID: P15927 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-69732   LT_SV40
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
single-stranded DNA binding,
protein binding		 nucleoplasm,
DNA replication factor A complex		 nucleotide-excision repair, DNA damage removal,
nucleotide-excision repair, DNA gap filling,
DNA-dependent DNA replication,
DNA recombination
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 21 SSSYGGAGGYTQSPGGFGSPA ATM 14872059
LTP
0.21
 MOD_PIKK_1
 - -
0.55
 --

Substrate: Serine/threonine-protein kinase 11 (Serine/threonine protein kinase 11)
Seq-ID: Q15831 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-56664   SNRK_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
magnesium ion binding,
protein serine/threonine kinase activity,
ATP binding		 cytoplasm,
nucleus		 protein amino acid phosphorylation,
cell cycle arrest,
regulation of fatty acid oxidation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 363 LFDIEDDIIYTQDFTVPGQVP ATM 12234250
LTP
0.08
 MOD_PIKK_1
 - -
0.45
 - medium

Substrate: Structural maintenance of chromosome 1-like 1 protein (Structural maintenance of chromosome 1-like 1 protein)
Seq-ID: Q14683 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14573   BRCA1_HUMAN
MINT-6492397   CTCF_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein heterodimerization activity,
microtubule motor activity,
chromatin binding,
ATP binding		 condensed nuclear chromosome,
condensed chromosome kinetochore,
cytoplasm,
cohesin core heterodimer		 cell division,
DNA repair,
negative regulation of DNA endoreduplication,
mitotic spindle organization,
mitotic sister chromatid cohesion,
response to radiation,
RNA splicing,
meiosis,
cell cycle checkpoint,
DNA damage response, signal transduction
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 957 MDDISQEEGSSQGEDSVSGSQ ATM 11877377
LTP
0.08
 MOD_PIKK_1
 - SMC_N
0.80
 - medium
S 966 SSQGEDSVSGSQRISSIYARE ATM 11877377
LTP
0.28
 MOD_PIKK_1
 - SMC_N
0.57
 - medium

Substrate: Telomeric repeat binding factor 1 (Telomeric repeat binding factor 1 (TTAGGG repeat binding factor 1) (NIMA-interacting protein 2) (Telomeric protein Pin2/TRF1))
Seq-ID: P54274 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14930   TINF2_HUMAN
MINT-16746   PINX1_HUMAN
MINT-17741   MARE1_HUMAN
MINT-17759   NDKA_HUMAN
MINT-62074   SMAD9_HUMAN
MINT-2831362   ORC2_HUMAN
MINT-6178188   STAG1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein heterodimerization activity,
protein homodimerization activity,
DNA bending activity,
telomeric DNA binding,
telomerase inhibitor activity,
microtubule binding,
caspase activator activity,
double-stranded telomeric DNA binding		 spindle,
nuclear telomere cap complex,
cytoplasm,
chromosome, telomeric region,
nucleoplasm,
nucleus		 negative regulation of telomere maintenance via semi-conservative replication,
cell division,
positive regulation of mitotic cell cycle,
activation of caspase activity,
regulation of transcription,
positive regulation of microtubule polymerization,
telomere maintenance via telomerase,
telomere maintenance via telomere shortening,
negative regulation of telomere maintenance via telomerase,
mitosis,
positive regulation of mitosis,
mitotic cell cycle spindle assembly checkpoint,
protein homooligomerization,
induction of apoptosis,
age-dependent telomere shortening,
G2/M transition of mitotic cell cycle,
negative regulation of telomerase activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 219 PFKSKLLMIISQKDTFHSFFQ ATM 11375976
LTP
0.12
 MOD_PIKK_1
 - TRF
0.10
 3BQO 70.49%

Substrate: Werner syndrome helicase (Werner syndrome helicase)
Seq-ID: Q14191 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-56621   H2AX_HUMAN
MINT-6550777   RAD52_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
G-quadruplex DNA binding,
magnesium ion binding,
manganese ion binding,
protein homodimerization activity,
3`-5` exonuclease activity,
ATP-dependent 3`-5` DNA helicase activity,
ATP binding,
bubble DNA binding,
four-way junction helicase activity,
Y-form DNA binding,
protein complex binding		 centrosome,
nucleolus,
nucleoplasm		 replication fork processing,
response to oxidative stress,
response to UV-C,
base-excision repair,
multicellular organismal aging,
regulation of apoptosis,
telomere maintenance,
DNA synthesis involved in DNA repair,
DNA recombination,
positive regulation of hydrolase activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 1141 VQSPEKAYSSSQPVISAQEQE ATM 11252893
LTP
0.60
 MOD_PIKK_1
 - -
0.53
 --
S 1141 VQSPEKAYSSSQPVISAQEQE ATM 10839545
LTP
0.60
 MOD_PIKK_1
 - -
0.53
 --
S 1292 LPLMTIGMHLSQAVKAGCPLD ATM 10608806
LTP
0.32
 MOD_PIKK_1
 - -
0.21
 --

Valid HTML 4.01 Transitional