List of substrates found:


Substrate: CDK5 activator 1
Seq-ID: Q15078 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
calcium ion binding,
cadherin binding		 plasma membrane,
neuronal cell body,
cyclin-dependent protein kinase 5 holoenzyme complex,
dendritic spine,
contractile fiber,
neuromuscular junction,
axon,
perinuclear region of cytoplasm,
growth cone		 brain development,
regulation of neuron differentiation,
axon guidance,
regulation of cyclin-dependent protein kinase activity,
positive regulation of neuron apoptosis,
neuron cell-cell adhesion,
ionotropic glutamate receptor signaling pathway,
muscarinic acetylcholine receptor signaling pathway,
axonal fasciculation,
neuron migration,
cell proliferation,
embryo development
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 8    MGTVLSLSPSYRKATLFE CDK5 18326489
LTP
1.00
 - CDK5_activator
0.33
 - medium
T 138 APHPAVTSAGTPKRVIVQAST CDK5 18326489
LTP
0.29
 MOD_CDK_SPxK_1
 - CDK5_activator
0.48
 - medium

Substrate: Doublecortin (Cytoskeletal associated protein)
Seq-ID: O88809 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein binding cytoplasm brain development,
neuron migration,
axon extension,
central nervous system projection neuron axonogenesis,
dendrite morphogenesis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 289 SAAAGPKASPTPQKTSAKSPG CDK5 15099191
LTP
0.28
 MOD_CDK_SPxK_1
 - -
0.90
 --
S 297 SPTPQKTSAKSPGPMRRSKSP CDK5 14741103
LTP
1.00
 - -
0.92
 --
S 297 SPTPQKTSAKSPGPMRRSKSP CDK5 15099191
LTP
1.00
 - -
0.92
 --

Substrate: Erzin (Connection of cytoscheletro structure to plasma membrane)
Seq-ID: P26040 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
MINT-4085294   TNR6_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cell adhesion molecule binding,
actin filament binding		 uropod,
actin filament,
microtubule basal body,
ruffle membrane,
microvillus membrane,
extrinsic to membrane,
apical plasma membrane,
cell cortex		 establishment or maintenance of apical/basal cell polarity,
regulation of cell shape,
actin filament bundle assembly
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 235 LNIYEKDDKLTPKIGFPWSEI CDK5 12769842
LTP
0.96
 - FERM_C
0.23
 - medium

Substrate: IPP1 (protein phosphatase inhibitor 1 (IPP-1) (from PhosphoBase))
Seq-ID: P19103 [Rattus norvegicus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoprotein phosphatase inhibitor activity signal transduction,
glycogen metabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 6      MEPDNSPRKIQFTVPL CDK5 17400554
LTP
0.16
 MOD_CDK_SPxK_1
 - DARPP-32
0.83
 - medium

Substrate: IPP2 (protein phosphatase inhibitor 2 (IPP-2) (from PhosphoBase))
Seq-ID: P41236 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine phosphatase inhibitor activity,
protein binding		 regulation of phosphoprotein phosphatase activity,
regulation of signal transduction,
glycogen metabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 73 YGLMKIDEPSTPYHSMMGDDE CDK5 11320080
LTP
1.00
 MOD_GSK3_1
 - IPP-2
0.70
 - high

Substrate: MAP2K1 (Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.1.-) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1))
Seq-ID: P31938 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
MINT-16657   BRAF_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
MAP kinase kinase activity,
ATP binding,
protein tyrosine kinase activity,
receptor signaling protein tyrosine phosphatase activity		 placenta blood vessel development,
positive regulation of cell differentiation,
cell motility,
keratinocyte differentiation,
labyrinthine layer development,
activation of MAPK activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 286 GCHVEGDAAETPPRPRTPGRP CDK5 11684694
LTP
0.12
 MOD_CDK_SPxK_1
 - S_TKc
0.70
 --
T 286 GCHVEGDAAETPPRPRTPGRP CDK5 15665076
LTP
0.12
 MOD_CDK_SPxK_1
 - S_TKc
0.70
 --

Substrate: Myocyte-specific enhancer factor 2A (Transcription factor)
Seq-ID: Q02078 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-49703   HDAC4_HUMAN
MINT-3380349   SUMO1_HUMAN
MINT-7973732   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
sequence-specific DNA binding,
sequence-specific DNA binding transcription factor activity		 nucleoplasm nervous system development,
transcription,
apoptosis,
muscle organ development,
regulation of transcription, DNA-dependent,
cell differentiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 408 QNISIKSEPISPPRDRMTPSG CDK5 12691662
LTP
1.00
 MOD_CDK_SPxK_1
 - -
0.88
 - medium

Substrate: Neurabin II protein (Cytoskeletal protein)
Seq-ID: Q6R891 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-4953730   RGS2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
actin binding filopodium,
dendritic spine,
cell junction,
cortical actin cytoskeleton,
synapse,
nucleus		 dendrite development,
actin filament organization,
regulation of protein amino acid phosphorylation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 17 RGPGGPLRSASPHRSAYEAGI CDK5 15728359
LTP
1.00
 MOD_CDK_SPxK_1
 - -
0.81
 - low

Substrate: Nude like protein (Cell cycle control protein)
Seq-ID: Q9ERR1 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-7686110   DC1I1_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
beta-tubulin binding,
microtubule binding,
alpha-tubulin binding		 centrosome,
spindle,
condensed chromosome kinetochore,
neurofilament cytoskeleton,
microtubule associated complex,
axon,
microtubule,
cell leading edge		 central nervous system neuron axonogenesis,
neurofilament cytoskeleton organization,
inner cell mass cell proliferation,
neuron migration,
activation of Cdc42 GTPase activity,
centrosome localization,
retrograde axon cargo transport,
vesicle transport along microtubule,
microtubule cytoskeleton organization
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 198 QEVTRKSAPSSPTLDCEKMDS CDK5 12796778
LTP
1.00
 - NUDE_C
0.68
 - medium
T 219 AVQASLSLPATPVGKGTENSF CDK5 12796778
LTP
1.00
 - NUDE_C
0.61
 - medium
S 231 VGKGTENSFPSPKAIPNGFGT CDK5 12796778
LTP
0.92
 - NUDE_C
0.69
 - medium
S 242 PKAIPNGFGTSPLTPSARISA CDK5 12796778
LTP
0.14
 - NUDE_C
0.55
 - medium
T 245 IPNGFGTSPLTPSARISALNI CDK5 12796778
LTP
1.00
 - NUDE_C
0.48
 - medium

Substrate: PCTAIRE1 (Serine/threonine-protein kinase PCTAIRE-1)
Seq-ID: Q04735 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cyclin-dependent protein kinase activity,
ATP binding		 protein amino acid phosphorylation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 95 ASATSSDEVQSPVRVRMRNHP CDK5 12084709
LTP
0.80
 MOD_CDK_SPxK_1
 - -
0.80
 - medium

Substrate: Presenilin 1 (Presenilin 1 (PS-1) (S182 protein))
Seq-ID: P49768 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14193   PKP4_HUMAN
MINT-15987   FLNB_HUMAN
MINT-16205   B2CL1_HUMAN
MINT-17726   FLNA_HUMAN
MINT-49819   CADH1_HUMAN
MINT-2837737   GSK3B_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
calcium channel activity,
beta-catenin binding,
endopeptidase activity,
PDZ domain binding		 centrosome,
Golgi membrane,
smooth endoplasmic reticulum,
integral to plasma membrane,
cell surface,
kinetochore,
nuclear outer membrane,
endoplasmic reticulum membrane,
rough endoplasmic reticulum,
gamma-secretase complex		 induction of apoptosis by extracellular signals,
membrane protein ectodomain proteolysis,
anti-apoptosis,
Notch receptor processing,
membrane protein intracellular domain proteolysis,
Notch signaling pathway,
amyloid precursor protein catabolic process,
cell-cell adhesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 354 RDSHLGPHRSTPESRAAVQEL CDK5 12056836
LTP
0.11
 - PSN
0.58
 - medium

Substrate: SDS3 (Enzyme: histone deacetylase)
Seq-ID: Q8BR65 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
identical protein binding,
histone deacetylase binding		 Sin3 complex chromatin modification,
transcription,
negative regulation of transcription
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 228 EDLRTLNKLKSPKRPASPSSP CDK5 15489224
LTP
0.17
 MOD_CDK_SPxK_1
 - -
0.73
 - low

Substrate: Serine/threonine-protein kinase PAK 1 (Ser/Thr protein kinase family)
Seq-ID: O88643 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19486   ARHG7_HUMAN
MINT-19793   NCK1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
ATP binding		 focal adhesion,
axon,
growth cone		 dendrite development,
protein amino acid phosphorylation,
neuromuscular junction development,
receptor clustering
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 212 TRSVIEPLPVTPTRDVATSPI CDK5 11604394
LTP
0.13
 MOD_CDK_SPxK_1
 - -
0.68
 --

Substrate: Src (Proto-oncogene tyrosine-protein kinase Src)
Seq-ID: P12931 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14765   DDR2_HUMAN
MINT-15459   CAV1_HUMAN
MINT-46002   CTNB1_MOUSE
MINT-50376   RASH_HUMAN
MINT-62340   KPCD_HUMAN
MINT-62342   CDCP1_HUMAN
MINT-65953   DYN1_HUMAN
MINT-65954   DYN2_HUMAN
MINT-68512   PDC6I_HUMAN
MINT-74753   ERBB3_HUMAN
MINT-2792760   PAK2_HUMAN
MINT-2793013   ADA15_HUMAN
MINT-2840132   TLR3_HUMAN
MINT-3381308   FAK1_HUMAN
MINT-3381360   FYN_HUMAN
MINT-4051815   ADRB2_HUMAN
MINT-4961196   AFAD_HUMAN
MINT-4980122   SNIP_MOUSE
MINT-5210599   SNIP_HUMAN
MINT-6539730   CBL_HUMAN
MINT-6771405   FAK1_MOUSE
MINT-6794909   ACTS_HUMAN
MINT-6795322   ACTN1_HUMAN
MINT-6795447   PTN1_HUMAN
MINT-7035260   HNRPK_HUMAN
MINT-7040283   CBLB_HUMAN
MINT-7104422   BCAR1_HUMAN
MINT-7145938   RL10_HUMAN
MINT-7244986   ASAP1_HUMAN
MINT-7244998   FANCA_HUMAN
MINT-7245022   PHAR2_HUMAN
MINT-7245034   ABL1_HUMAN
MINT-7245058   DLGP4_HUMAN
MINT-7245070   SNX17_HUMAN
MINT-7245106   RTN4_HUMAN
MINT-7245118   ASAP2_HUMAN
MINT-7245142   E41L3_HUMAN
MINT-7245154   ICAL_HUMAN
MINT-7245214   FCG2B_HUMAN
MINT-7245226   FCG2C_HUMAN
MINT-7245334   SHAN2_HUMAN
MINT-7245346   SHRM2_HUMAN
MINT-7245358   DNLI3_HUMAN
MINT-7245370   EIF3D_HUMAN
MINT-7245406   HCN2_HUMAN
MINT-7245490   CKAP5_HUMAN
MINT-7245502   M4K1_HUMAN
MINT-7245538   RPP38_HUMAN
MINT-7245562   SP1_HUMAN
MINT-7245574   DOCK1_HUMAN
MINT-7245586   RLGPB_HUMAN
MINT-7245598   ABL2_HUMAN
MINT-7245610   CELR2_HUMAN
MINT-7245622   SOS1_HUMAN
MINT-7245634   AKAP6_HUMAN
MINT-7245670   DPOD1_HUMAN
MINT-7245682   DAG1_HUMAN
MINT-7245694   SNX3_HUMAN
MINT-7245730   KI67_HUMAN
MINT-7245742   CD97_HUMAN
MINT-7245754   RPGF1_HUMAN
MINT-7245778   ACAP1_HUMAN
MINT-7245790   PRIC3_HUMAN
MINT-7245814   AKAP2_HUMAN
MINT-7245826   RRAS_HUMAN
MINT-7296136   P85A_HUMAN
MINT-7296149   ACTB_HUMAN
MINT-7306598   LCP2_HUMAN
MINT-7552515   PTPRA_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3/SH2 adaptor activity,
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
integrin binding,
SH2 domain binding		 caveola,
cytosol		 protein amino acid phosphorylation,
regulation of bone resorption,
signal complex assembly,
regulation of vascular permeability,
response to interleukin-1,
interspecies interaction between organisms,
Ras protein signal transduction,
positive regulation of integrin activation,
intracellular protein kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 75 GGFNSSDTVTSPQRAGPLAGG CDK5 10544291
LTP
0.14
 MOD_CDK_SPxK_1
 - -
0.64
 --

Substrate: STXB2 (Unclassified)
Seq-ID: Q15833 [Homo sapiens]
Download:fasta csv
Interaction Network(s):
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
syntaxin-3 binding plasma membrane,
cytosol,
tertiary granule,
specific granule,
azurophil granule		 vesicle docking involved in exocytosis,
protein transport,
neutrophil degranulation,
regulation of mast cell degranulation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 572 EVLIGSSHILTPTRFLDDLKA CDK5 17716669
LTP
1.00
 MOD_CDK_SPxK_1
 - Sec1
0.15
 - medium

Substrate: Syntaxin binding protein 1 (Syntaxin binding protein 1 (Unc-18 homolog) (Unc-18A) (Unc-18-1) (N- Sec1) (rbSec1) (p67))
Seq-ID: O08599 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
syntaxin-1 binding mitochondrion vesicle docking involved in exocytosis,
synaptic vesicle maturation,
protein transport,
long term synaptic depression,
neurotransmitter secretion,
negative regulation of neuron apoptosis,
negative regulation of synaptic transmission, GABAergic,
axon target recognition,
neuromuscular synaptic transmission
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 574 EVLIGSTHILTPQKLLDTLKK CDK5 9933594
LTP
0.98
 MOD_CDK_SPxK_1
 - Sec1
0.19
 3C98 11.64%

Substrate: Tyr-3-hydroxylase (tyrosine 3-monooxygenase (tyrosine 3-hydroxylase) (TH) (from PhosphoBase))
Seq-ID: P24529 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
tyrosine 3-monooxygenase activity perikaryon,
nucleus		 synaptic transmission, dopaminergic,
eating behavior,
embryonic camera-type eye morphogenesis,
neurotransmitter biosynthetic process,
oxidation reduction,
learning,
eye photoreceptor cell development,
regulation of heart contraction,
visual perception,
heart development,
dopamine biosynthetic process from tyrosine,
locomotory behavior,
memory,
mating behavior
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 31 QDTKQAEAVTSPRFIGRRQSL CDK5 15447670
LTP
0.84
 - -
0.58
 - medium
S 31 QDTKQAEAVTSPRFIGRRQSL CDK5 15471880
LTP
0.84
 - -
0.58
 - medium

Substrate: Voltage-dependent L-type calcium channel alpha-1C subunit (dihydropyridine-sensitive L-type, cardiac muscle calcium channel (from PhosphoBase))
Seq-ID: Q01815 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
dihydropyridine-sensitive calcium channel activity,
protein binding		 neuronal cell body,
membrane fraction,
dendritic shaft,
T-tubule,
caveolar macromolecular signaling complex,
voltage-gated calcium channel complex		 glucose homeostasis,
regulation of blood pressure,
regulation of vasoconstriction,
growth hormone secretion,
smooth muscle contraction involved in micturition,
calcium ion-dependent exocytosis,
cellular calcium ion homeostasis,
adult walking behavior,
visual learning,
regulation of organ growth,
synaptic transmission,
insulin secretion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 783 KERKKLARTASPEKKQEVMEK CDK5 16155576
LTP
1.00
 MOD_CDK_SPxK_1
 - -
0.70
 - medium

Valid HTML 4.01 Transitional