Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

Substrate:

Arachidonate 5 lipoxygenase (Enzyme: Lipase)

Seq-ID:

P09917 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
arachidonate 5-lipoxygenase activity, iron ion binding, lipoxygenase activity, protein binding	nuclear envelope lumen, cytosol, nuclear membrane, nuclear matrix	oxidation reduction, leukotriene biosynthetic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	272	MVECSLERQLSLEQEVQQGNI	CaM-KII_alpha	11844797	LTP	0.64		-	Lipoxygenase	0.18	-	high

Substrate:

C-ets-1 protein (C-ets-1 protein)

Seq-ID:

P14921 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-16586 DAXX_HUMAN
MINT-5207365 ANDR_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, RNA polymerase II transcription factor activity, transcription factor binding, sequence-specific DNA binding transcription factor activity, protein binding	nucleus	transcription from RNA polymerase II promoter, positive regulation of gene-specific transcription from RNA polymerase II promoter, positive regulation of transcription, transcription, cell motility, negative regulation of cell proliferation, positive regulation of cellular component movement, immune response, PML body organization, positive regulation of erythrocyte differentiation, response to antibiotic, induction of apoptosis, negative regulation of cell cycle

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	251	TSRGKLGGQDSFESIESYDSC	CaM-KII_alpha	12475968	LTP	0.52	-	-	0.43	-	-
S	257	GGQDSFESIESYDSCDRLTQS	CaM-KII_alpha	12475968	LTP	0.39	-	-	0.36	-	-
S	282	SSFNSLQRVPSYDSFDSEDYP	CaM-KII_alpha	12475968	LTP	0.55	-	-	0.38	-	-
S	285	NSLQRVPSYDSFDSEDYPAAL	CaM-KII_alpha	12475968	LTP	0.36	-	-	0.40	-	-

Substrate:

CaMK-II alpha subunit (calcium/calmodulin-dependent protein kinase type II alpha chain (from PhosphoBase))

Seq-ID:

Q9UQM7 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-17826   GRIA4_HUMAN
MINT-45875   ACTN1_HUMAN
MINT-5114580   ZN363_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
ATP binding, calmodulin-dependent protein kinase activity, calmodulin binding	endocytic vesicle membrane, cell junction, presynaptic membrane, cytosol, nucleoplasm	protein amino acid phosphorylation, positive regulation of NF-kappaB transcription factor activity

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	286	TVASCMHRQETVDCLKKFNAR	CaM-KII_alpha	16172120	LTP	1.00		-	-	0.30	2VZ6	2.05%

Substrate:

CLCN3 (PDZ domain binding, protein binding)

Seq-ID:

P51790 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
antiporter activity, protein heterodimerization activity, protein homodimerization activity, ATP binding, voltage-gated chloride channel activity, PDZ domain binding	Golgi membrane, early endosome membrane, transport vesicle membrane, cell surface, integral to membrane, late endosome membrane	endosomal lumen acidification

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	51	KDRERHRRINSKKKESAWEMT	CaM-KII_alpha	14754994	LTP	0.20		-	-	0.41	-	medium

Substrate:

CPI-17 (Inhibitor of PPP1CA)

Seq-ID:

Q96A00 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-16604 KC1A_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphoprotein phosphatase inhibitor activity, protein binding	cytoplasm	regulation of phosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	130	RQPGLRQPSPSHDGSLSPLQD	CaM-KII_alpha	12604330	LTP	0.02		-	PP1_inhibitor	0.85	-	medium

Substrate:

Cytosolic phospholipase A2 (Enzyme: Phospholipase)

Seq-ID:

P47712 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
lysophospholipase activity	cytosol, integral to membrane, endoplasmic reticulum membrane	platelet activating factor biosynthetic process, phospholipid catabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	515	SPLSDFATQDSFDDDELDAAV	CaM-KII_alpha	11479288	LTP	0.56		-	PLAc	0.45	-	-

Substrate:

EGFR (Receptor for EGF and other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor,)

Seq-ID:

P00533 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-16802   GRB10_HUMAN
MINT-50935   1433Z_HUMAN
MINT-51101   ANXA1_HUMAN
MINT-51490   ARBK1_HUMAN
MINT-60973   CBL_HUMAN
MINT-61486   CRKL_HUMAN
MINT-61487   CSK_HUMAN
MINT-61490   STA5B_HUMAN
MINT-61540   GRB2_HUMAN
MINT-68514   PDC6I_HUMAN
MINT-74427   ABL1_HUMAN
MINT-74438   ABL2_HUMAN
MINT-74460   ANS1A_HUMAN
MINT-74469   APBB1_HUMAN
MINT-74479   DP13A_HUMAN
MINT-74487   BMX_HUMAN
MINT-74497   CRK_HUMAN
MINT-74535   FES_HUMAN
MINT-74551   IRS1_HUMAN
MINT-74555   IRS4_HUMAN
MINT-74562   JAK2_HUMAN
MINT-74566   SH2B3_HUMAN
MINT-74572   JIP1_HUMAN
MINT-74587   NCK1_HUMAN
MINT-74593   NUMB_HUMAN
MINT-74594   NUMBL_HUMAN
MINT-74606   P85A_HUMAN
MINT-74630   P85B_HUMAN
MINT-74659   P55G_HUMAN
MINT-74678   PLCG1_HUMAN
MINT-74685   PLCG2_HUMAN
MINT-74687   PTK6_HUMAN
MINT-74689   PTN11_HUMAN
MINT-74711   RASA1_HUMAN
MINT-74717   SH2B1_HUMAN
MINT-74720   SH22A_HUMAN
MINT-74732   SHC1_HUMAN
MINT-74746   SLAP1_HUMAN
MINT-74763   KSYK_HUMAN
MINT-74790   TLN1_HUMAN
MINT-74807   ZAP70_HUMAN
MINT-1788719   ERBB2_HUMAN
MINT-6169667   ESR1_HUMAN
MINT-6170031   SOS1_MOUSE
MINT-6170198   SH3G2_HUMAN
MINT-6170268   SH3K1_HUMAN
MINT-6793358   PTN1_HUMAN
MINT-7980526   TM1L1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
epidermal growth factor receptor activity, protein heterodimerization activity, identical protein binding, receptor signaling protein tyrosine kinase activity, double-stranded DNA binding, ATP binding, protein phosphatase binding, actin filament binding, MAP/ERK kinase kinase activity	Shc-EGFR complex, endosome, basolateral plasma membrane, integral to membrane, extracellular space, nucleus	activation of phospholipase C activity, protein insertion into membrane, response to UV-A, positive regulation of nitric oxide biosynthetic process, positive regulation of cell migration, positive regulation of cyclin-dependent protein kinase activity involved in G1/S, positive regulation of catenin protein nuclear translocation, regulation of nitric-oxide synthase activity, positive regulation of protein kinase B signaling cascade, ossification, positive regulation of epithelial cell proliferation, activation of phospholipase A2 activity by calcium-mediated signaling, cell-cell adhesion, regulation of peptidyl-tyrosine phosphorylation, positive regulation of phosphorylation, positive regulation of MAP kinase activity, cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	768	EILDEAYVMASVDNPHVCRLL	CaM-KII_alpha	10347170	LTP	1.00	-	TyrKc	0.10	3BEL	38.52%
S	1070	IKEDSFLQRYSSDPTGALTED	CaM-KII_alpha	10347170	LTP	1.00	-	-	0.59	-	-
S	1071	KEDSFLQRYSSDPTGALTEDS	CaM-KII_alpha	10347170	LTP	0.09	-	-	0.61	-	-
S	1081	SDPTGALTEDSIDDTFLPVPE	CaM-KII_alpha	10347170	LTP	0.23	-	-	0.60	-	-
S	1166	HWAQKGSHQISLDNPDYQQDF	CaM-KII_alpha	10347170	LTP	0.25	-	-	0.64	-	-

Substrate:

ErbB2 (Receptor tyrosine kinase)

Seq-ID:

P04626 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-61505   P85B_HUMAN
MINT-74429   ABL1_HUMAN
MINT-74444   ABL2_HUMAN
MINT-74462   ANS1A_HUMAN
MINT-74470   APBB1_HUMAN
MINT-74486   BLNK_HUMAN
MINT-74488   BMX_HUMAN
MINT-74498   CRK_HUMAN
MINT-74502   CRKL_HUMAN
MINT-74508   DAB1_HUMAN
MINT-74512   DOK1_HUMAN
MINT-74521   SPT6H_HUMAN
MINT-74533   FER_HUMAN
MINT-74538   FGR_HUMAN
MINT-74540   GRAP2_HUMAN
MINT-74542   GRB2_HUMAN
MINT-74544   GRB7_HUMAN
MINT-74553   IRS1_HUMAN
MINT-74556   IRS4_HUMAN
MINT-74558   ITK_HUMAN
MINT-74561   JAK1_HUMAN
MINT-74567   SH2B3_HUMAN
MINT-74575   JIP1_HUMAN
MINT-74582   MATK_HUMAN
MINT-74590   NCK2_HUMAN
MINT-74610   P85A_HUMAN
MINT-74664   P55G_HUMAN
MINT-74680   PLCG1_HUMAN
MINT-74686   PLCG2_HUMAN
MINT-74691   PTN11_HUMAN
MINT-74712   RASA1_HUMAN
MINT-74713   RIN1_HUMAN
MINT-74722   SH22A_HUMAN
MINT-74723   SH23A_HUMAN
MINT-74724   3BP2_HUMAN
MINT-74737   SHC1_HUMAN
MINT-74747   SLAP1_HUMAN
MINT-74755   STAT1_HUMAN
MINT-74756   STAT3_HUMAN
MINT-74769   KSYK_HUMAN
MINT-74777   TEC_HUMAN
MINT-74781   TENC1_HUMAN
MINT-74786   TENS3_HUMAN
MINT-74793   TLN1_HUMAN
MINT-74794   TXK_HUMAN
MINT-74802   VAV2_HUMAN
MINT-1788719   EGFR_HUMAN
MINT-1901925   LAP2_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
epidermal growth factor receptor activity, ErbB-3 class receptor binding, protein heterodimerization activity, DNA binding, protein C-terminus binding, identical protein binding, receptor signaling protein tyrosine kinase activity, ATP binding, protein phosphatase binding	receptor complex, integral to membrane, nucleus, perinuclear region of cytoplasm	regulation of angiogenesis, transcription, regulation of transcription, phosphoinositide 3-kinase cascade, phosphoinositide-mediated signaling, heart development, positive regulation of cell adhesion, protein amino acid autophosphorylation, positive regulation of epithelial cell proliferation, wound healing, positive regulation of MAP kinase activity, cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	1172	PAGATLERPKTLSPGKNGVVK	CaM-KII_alpha	8700533	LTP	0.30		-	-	0.76	-	low

Substrate:

GABA(A) receptor G2 (Gamma-aminobutyric-acid receptor gamma-2 subunit precursor (from PhosphoBase))

Seq-ID:

P22723 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
GABA-A receptor activity, chloride channel activity, extracellular ligand-gated ion channel activity, protein binding	cell junction, chloride channel complex, postsynaptic membrane	post-embryonic development, adult behavior, synaptic transmission, gamma-aminobutyric acid signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	381	KKKNPLLRMFSFKAPTIDIRP	CaM-KII_alpha	8027073	LTP	0.23	-	Neur_chan_memb	0.11	-	medium
S	393	KAPTIDIRPRSATIQMNNATH	CaM-KII_alpha	8027073	LTP	0.18	-	Neur_chan_memb	0.27	-	medium
T	395	PTIDIRPRSATIQMNNATHLQ	CaM-KII_alpha	8027073	LTP	0.19	-	Neur_chan_memb	0.32	-	medium

Substrate:

GABA(A) receptor B1 (gamma-aminobutyric-acid receptor beta-1 subunit precursor (from PhosphoBase))

Seq-ID:

P50571 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
chloride channel activity, extracellular ligand-gated ion channel activity	cell junction, chloride channel complex, postsynaptic membrane

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	409	SASIQYRKPLSSREGFGRGLD	CaM-KII_alpha	8027073	LTP	0.26		-	Neur_chan_memb	0.30	-	low
S	434	PGKGRIRRRASQLKVKIPDLT	CaM-KII_alpha	8027073	LTP	0.79		-	Neur_chan_memb	0.43	-	low

Substrate:

HRH1 (G-protein coupled receptor activity, histamine receptor activity)

Seq-ID:

P35367 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
histamine receptor activity	integral to plasma membrane	inflammatory response, activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	140	QQPLRYLKYRTKTRASATILG	CaM-KII_alpha	15107581	LTP	1.00	-	7tm_1	0.04	-	medium
T	142	PLRYLKYRTKTRASATILGAW	CaM-KII_alpha	15107581	LTP	0.13	-	7tm_1	0.03	-	medium
S	396	YIKFTWKRLRSHSRQYVSGLH	CaM-KII_alpha	15107581	LTP	0.22	-	7tm_1	0.12	-	medium
S	398	KFTWKRLRSHSRQYVSGLHMN	CaM-KII_alpha	15107581	LTP	1.00	-	7tm_1	0.19	-	medium

Substrate:

HSF 1 (Transcription factor)

Seq-ID:

Q00613 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-1785958 STUB1_HUMAN
MINT-6743391 STRAP_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding transcription factor activity, protein binding	cytoplasm	transcription, regulation of transcription, DNA-dependent

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	230	HSMPKYSRQFSLEHVHGSGPY	CaM-KII_alpha	11447121	LTP	1.00		-	-	0.54	-	high

Substrate:

IL-6R (gp130) (gp130 is shared by members of the IL-6 family)

Seq-ID:

Q00560 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-3382101 SOCS3_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	external side of plasma membrane	regulation of Notch signaling pathway, glycogen metabolic process, positive regulation of astrocyte differentiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	780	PSVQVFSRSESTQPLLDSEER	CaM-KII_alpha	16036214	LTP	1.00		-	-	0.68	-	medium

Substrate:

IP3 3-kinase (Enzyme: Phosphorylase)

Seq-ID:

P23677 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
inositol trisphosphate 3-kinase activity, ATP binding, calmodulin binding		signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	311	TEEEHAQRAVTKPRYMQWREG	CaM-KII_alpha	9155020	LTP	1.00		-	IPK	0.48	1W2C	22.60%

Substrate:

Myogenin (Transcription factor)

Seq-ID:

P12979 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-7222760 UBIQ_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription activator activity, RNA polymerase II transcription factor activity, enhancer binding	nucleus	ossification, cellular response to lithium ion, skeletal muscle fiber development, positive regulation of transcription from RNA polymerase II promoter, cellular response to growth factor stimulus

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	87	SVSVDRRRAATLREKRRLKKV	CaM-KII_alpha	14751541	LTP	1.00		-	HLH	0.49	-	medium

Substrate:

Nitric-oxide synthase, brain (Enzyme: Synthetase)

Seq-ID:

P29475 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-3999982 VAC14_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
arginine binding, heme binding, cadmium ion binding, NADP or NADPH binding, FAD binding, calmodulin binding, nitric-oxide synthase activity, tetrahydrobiopterin binding, FMN binding	sarcolemma, sarcoplasmic reticulum, dendritic spine, cytoskeleton, photoreceptor inner segment, perinuclear region of cytoplasm	positive regulation of vasodilation, neurotransmitter biosynthetic process, myoblast fusion, oxidation reduction, response to hypoxia, response to heat, arginine catabolic process, negative regulation of calcium ion transport into cytosol, multicellular organismal response to stress, regulation of cardiac muscle contraction, nitric oxide biosynthetic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	852	ERKSYKVRFNSVSSYSDSQKS	CaM-KII_alpha	10400690	LTP	0.33	-	Flavodoxin_1	0.37	-	medium
S	852	ERKSYKVRFNSVSSYSDSQKS	CaM-KII_alpha	10874031	LTP	0.33	-	Flavodoxin_1	0.37	-	medium
S	852	ERKSYKVRFNSVSSYSDSQKS	CaM-KII_alpha	12630910	LTP	0.33	-	Flavodoxin_1	0.37	-	medium

Substrate:

Phospholamban (Integral membrane protein)

Seq-ID:

P61014 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium channel regulator activity, protein binding	sarcoplasmic reticulum, mitochondrial membrane, integral to membrane	cardiac muscle tissue development, cellular calcium ion homeostasis, regulation of calcium ion transport, regulation of the force of heart contraction, negative regulation of heart contraction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	16	YLTRSAIRRASTIEMPQQARQ	CaM-KII_alpha	2544595	LTP	-	MOD_PKA_1	-	Phospholamban	0.12	-	-
T	17	LTRSAIRRASTIEMPQQARQN	CaM-KII_alpha	10988285	LTP	-		-	Phospholamban	0.13	-	-
T	17	LTRSAIRRASTIEMPQQARQN	CaM-KII_alpha	2544595	LTP	-		-	Phospholamban	0.13	-	-

Substrate:

PLC beta 3 (Enzyme: Phospholipase)

Seq-ID:

Q01970 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-62354   PARD3_HUMAN
MINT-62355   PAR6A_HUMAN
MINT-73251   NHRF1_HUMAN
MINT-73254   EZRI_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium ion binding, phosphoinositide phospholipase C activity, signal transducer activity	cytosol	lipid catabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	537	LEKPSLEPQKSLGDEGLNRGP	CaM-KII_alpha	11325525	LTP	1.00		-	-	0.81	-	medium

Substrate:

Ryanodine receptor 2 (ryanodine receptor, cardiac muscle (from PhosphoBase))

Seq-ID:

Q92736 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19826 DYN2_MOUSE
MINT-61836 SMAD5_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
receptor activity, calcium ion binding, identical protein binding, ryanodine-sensitive calcium-release channel activity, protein kinase A regulatory subunit binding, suramin binding, calmodulin binding, protein kinase A catalytic subunit binding	plasma membrane, calcium channel complex, plasma membrane enriched fraction, sarcoplasmic reticulum membrane	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum, response to hypoxia, regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion, cardiac muscle contraction, induction of apoptosis by ionic changes, response to caffeine, detection of calcium ion, response to redox state

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	2808	MALYNRTRRISQTSQVSVDAA	CaM-KII_alpha	14514795	LTP	0.85	MOD_PKA_1	-	-	0.42	-	medium

Substrate:

Tyr-3-hydroxylase (tyrosine 3-monooxygenase (tyrosine 3-hydroxylase) (TH) (from PhosphoBase))

Seq-ID:

P07101 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
tyrosine 3-monooxygenase activity, protein binding	smooth endoplasmic reticulum, perikaryon, internal side of plasma membrane, cytosol, melanosome membrane, nucleus	synaptic transmission, dopaminergic, embryonic camera-type eye morphogenesis, neurotransmitter biosynthetic process, oxidation reduction, response to hypoxia, heart morphogenesis, learning, eye photoreceptor cell development, regulation of heart contraction, visual perception, norepinephrine biosynthetic process, dopamine biosynthetic process from tyrosine, locomotory behavior, memory, epinephrine biosynthetic process, pigmentation, response to ethanol

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	19	PQAKGFRRAVSELDAKQAEAI	CaM-KII_alpha	1680128	LTP	1.00		-	-	0.58	-	low
S	71	RSPRFIGRRQSLIEDARKERE	CaM-KII_alpha	1680128	LTP	1.00	MOD_PKA_1	-	-	0.61	-	low

Substrate:

Vimentin (vimentin (from PhosphoBase))

Seq-ID:

P08670 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-48218   NEMO_HUMAN
MINT-48335   M3K1_HUMAN
MINT-48490   M3K3_HUMAN
MINT-48555   NFKB1_HUMAN
MINT-49072   RIPK2_HUMAN
MINT-49446   TNR1B_HUMAN
MINT-51249   SMAD3_HUMAN
MINT-63478   FABP4_HUMAN
MINT-63483   CREB1_HUMAN
MINT-63519   SYN1_HUMAN
MINT-64054   RAD51_HUMAN
MINT-64131   TIF1B_HUMAN
MINT-64137   NFAC2_HUMAN
MINT-64185   CASP8_HUMAN
MINT-64286   STX1A_HUMAN
MINT-64820   Q86V38_HUMAN
MINT-64930   SIRT6_HUMAN
MINT-64945   CA103_HUMAN
MINT-64988   PAIRB_HUMAN
MINT-65109   FUBP1_HUMAN
MINT-65490   TARA_HUMAN
MINT-65741   PUF60_HUMAN
MINT-65855   SRRT_HUMAN
MINT-65878   NS1BP_HUMAN
MINT-66105   MYST2_HUMAN
MINT-66208   ABLM1_HUMAN
MINT-66844   K1C20_HUMAN
MINT-66894   GFAP_HUMAN
MINT-67503   PDLI1_HUMAN
MINT-67553   PSA1_HUMAN
MINT-67944   GOPC_HUMAN
MINT-2515544   SYUA_HUMAN
MINT-2791056   RD23A_HUMAN
MINT-2791422   RD23B_HUMAN
MINT-2985160   ZO1_HUMAN
MINT-3297793   1433Z_HUMAN
MINT-3979536   CHD3_HUMAN
MINT-3979774   ZHX1_HUMAN
MINT-3980301   SETB1_HUMAN
MINT-3980318   NFL_HUMAN
MINT-3980438   ING5_HUMAN
MINT-3980472   PPHLN_HUMAN
MINT-3980489   UT14A_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein C-terminus binding, structural constituent of cytoskeleton	intermediate filament, cytosol	cellular component movement, interspecies interaction between organisms

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	83	SVPGVRLLQDSVDFSLADAIN	CaM-KII_alpha	9794428	LTP	0.69		-	Filament_head	0.30	-	-
S	83	SVPGVRLLQDSVDFSLADAIN	CaM-KII_alpha	16140754	LTP	0.69		-	Filament_head	0.30	-	-