Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

Substrate:

Alpha-NAC (Unclassified)

Seq-ID:

Q13765 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-64154   CC90B_HUMAN
MINT-64155   FUND2_HUMAN
MINT-64156   CA103_HUMAN
MINT-64157   ZHX1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
DNA binding	nascent polypeptide-associated complex, nucleus	transcription, protein transport, interspecies interaction between organisms, translation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	159	AVSNIQENTQTPTVQEESEEE	GSK-3_beta	15005626	LTP	0.77	MOD_GSK3_1	-	-	0.79	-	medium

Substrate:

Amyloid beta A4 protein (Cell surface receptor)

Seq-ID:

P05067 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14547   JIP1_HUMAN
MINT-49648   APBB1_RAT
MINT-49659   GRB2_HUMAN
MINT-49660   SHC1_HUMAN
MINT-49984   ABL1_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
serine-type endopeptidase inhibitor activity, DNA binding, acetylcholine receptor binding, identical protein binding, metal ion binding, heparin binding	extracellular region, dendritic shaft, integral to plasma membrane, coated pit, cell surface, Golgi apparatus, platelet alpha granule lumen, axon, dendritic spine	dendrite development, G2 phase of mitotic cell cycle, positive regulation of mitotic cell cycle, regulation of multicellular organism growth, regulation of epidermal growth factor receptor activity, ionotropic glutamate receptor signaling pathway, mRNA polyadenylation, collateral sprouting in the absence of injury, adult locomotory behavior, extracellular matrix organization, Notch signaling pathway, regulation of translation, visual learning, neuron apoptosis, axon midline choice point recognition, cell adhesion, neuron remodeling, mating behavior, endocytosis, axon cargo transport, cellular copper ion homeostasis, protein amino acid phosphorylation, regulation of synapse structure and activity

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	743	HGVVEVDAAVTPEERHLSKMQ	GSK-3_beta	8764598	LTP	1.00		-	APP_amyloid	0.47	-	-

Substrate:

Ataxin 3 (DNA repair protein)

Seq-ID:

P54252 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-2790957   RD23B_HUMAN
MINT-2837891   TERA_HUMAN
MINT-2858647   EWS_HUMAN
MINT-2862451   RD23A_HUMAN
MINT-2877777   RHG19_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
ubiquitin thiolesterase activity, cysteine-type peptidase activity, protein binding	cytoplasm, nuclear matrix, nucleoplasm	nervous system development, transcription, regulation of transcription, synaptic transmission, nucleotide-excision repair, cell death

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	256	EADLRRAIQLSMQGSSRNISQ	GSK-3_beta	17434145	LTP	1.00	MOD_GSK3_1	-	UIM	0.63	-	medium

Substrate:

Axin1 (Adapter molecule)

Seq-ID:

O35625 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein complex scaffold, I-SMAD binding, protein C-terminus binding, protein homodimerization activity, specific transcriptional repressor activity, protein kinase binding, ubiquitin protein ligase binding, beta-catenin binding, signal transducer activity	Axin-APC-beta-catenin-GSK3B complex, cytoplasmic membrane-bounded vesicle, glycoprotein network, soluble fraction, nucleus, cell cortex	negative regulation of gene-specific transcription elongation from RNA polymerase II promoter, positive regulation of transcription, dorsal/ventral axis specification, negative regulation of fat cell differentiation, tail morphogenesis, apoptosis, positive regulation of JUN kinase activity, sensory perception of sound, axial mesoderm formation, genetic imprinting, negative regulation of Wnt receptor signaling pathway, canonical Wnt receptor signaling pathway, negative regulation of protein metabolic process, protein catabolic process, positive regulation of ubiquitin-protein ligase activity, positive regulation of JNK cascade, protein homooligomerization

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	480	LDEHVQRVMRTPGCQSPGPGH	GSK-3_beta	10581160	LTP	1.00		-	Axin_b-cat_bind	0.84	-	medium
S	485	QRVMRTPGCQSPGPGHRSPDS	GSK-3_beta	10581160	LTP	1.00		-	Axin_b-cat_bind	0.91	-	medium

Substrate:

c-myc (Myc proto-oncogene protein (c-myc))

Seq-ID:

P01106 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-25075   MAX_HUMAN
MINT-6628157   VE7_HPV16
MINT-7040788   AXN1_HUMAN
MINT-7306800   BIN1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription activator activity, E-box binding, sequence-specific DNA binding transcription factor activity	nucleolus	branching involved in ureteric bud morphogenesis, cellular iron ion homeostasis, cell cycle arrest, response to drug, cell proliferation, positive regulation of metanephric cap mesenchymal cell proliferation, regulation of telomere maintenance

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	58	DIWKKFELLPTPPLSPSRRSG	GSK-3_beta	14563837	LTP	1.00	MOD_GSK3_1	-	Myc_N	0.38	-	low

Substrate:

C/EBP beta (Transcription factor)

Seq-ID:

P28033 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein heterodimerization activity, protein homodimerization activity, transcription activator activity, RNA polymerase II transcription factor activity, enhancer binding	cytoplasm	mammary gland epithelial cell differentiation, regulation of interleukin-6 biosynthetic process, transcription, mammary gland epithelial cell proliferation, anti-apoptosis, embryonic placenta development, brown fat cell differentiation, response to lipopolysaccharide, induction of apoptosis, positive regulation of transcription from RNA polymerase II promoter, neuron differentiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	179	TPSGSSGSLSTSSSSSPPGTP	GSK-3_beta	15985551	LTP	0.29	MOD_GSK3_1	-	-	0.88	-	medium
S	184	SGSLSTSSSSSPPGTPSPADA	GSK-3_beta	15985552	LTP	0.18	MOD_GSK3_1	-	-	0.87	-	medium

Substrate:

CCND3 (protein binding)

Seq-ID:

P30281 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-50438   CDK4_HUMAN
MINT-50439   CDK6_HUMAN
MINT-50440   MCM10_HUMAN
MINT-50441   CDN1A_HUMAN
MINT-50583   EIF3K_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein kinase binding	cytoplasm, cyclin-dependent protein kinase holoenzyme complex, nucleus	positive regulation of protein amino acid phosphorylation, cell division, positive regulation of cyclin-dependent protein kinase activity

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	283	SSSQGPSQTSTPTDVTAIHL	GSK-3_beta	15326477	LTP	0.98	MOD_GSK3_1	-	Cyclin_C	0.74	-	medium
T	283	SSSQGPSQTSTPTDVTAIHL	GSK-3_beta	15252116	LTP	0.98	MOD_GSK3_1	-	Cyclin_C	0.74	-	medium

Substrate:

CD227 (CD antigen)

Seq-ID:

P15941 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-2880967 ABL1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	extracellular region, cytoplasm, integral to plasma membrane, nucleus, apical plasma membrane

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1227	RYVPPSSTDRSPYEKVSAGNG	GSK-3_beta	9819408	LTP	0.24	MOD_GSK3_1	-	-	0.55	-	low

Substrate:

Cryptochrome-2 (Transcription regulatory protein)

Seq-ID:

Q9R194 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
nucleotide binding, photoreceptor activity, DNA photolyase activity, protein binding	cytoplasm, nucleus	transcription, DNA repair, protein import into nucleus, regulation of transcription, protein-chromophore linkage, circadian rhythm

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	553	ISNTGPRALSSGPASPKRKLE	GSK-3_beta	15980066	LTP	0.10	MOD_GSK3_1	-	-	0.74	-	low
S	557	GPRALSSGPASPKRKLEAAEE	GSK-3_beta	15980066	LTP	0.33	MOD_GSK3_1	-	-	0.79	-	low

Substrate:

Cyclin D1 (Cyclin D1)

Seq-ID:

P25322 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-7033488 CDK4_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cyclin-dependent protein kinase regulator activity, protein kinase binding, protein kinase activity	cytosol, cyclin-dependent protein kinase holoenzyme complex, nucleoplasm	protein amino acid phosphorylation, fat cell differentiation, cell division, mitotic cell cycle G1/S DNA damage checkpoint, mammary gland epithelial cell proliferation, G1/S transition of mitotic cell cycle, negative regulation of epithelial cell differentiation, negative regulation of Wnt receptor signaling pathway, canonical Wnt receptor signaling pathway, lactation, re-entry into mitotic cell cycle, endoplasmic reticulum unfolded protein response, mammary gland alveolus development

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	286	EVEEEAGLACTPTDVRDVDI	GSK-3_beta	15075324	LTP	1.00		-	Cyclin_C	0.44	-	medium
T	286	EVEEEAGLACTPTDVRDVDI	GSK-3_beta	11124803	LTP	1.00		-	Cyclin_C	0.44	-	medium

Substrate:

Cyclin E1 (Cell cycle control protein)

Seq-ID:

P24864 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14269   FBXW7_HUMAN
MINT-1788668   FOXM1_HUMAN
MINT-2635177   CDN1A_HUMAN
MINT-2983466   CDK2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
androgen receptor binding, transcription coactivator activity	cytosol, nucleoplasm	cell division, positive regulation of transcription, DNA-dependent, G1/S transition of mitotic cell cycle, androgen receptor signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	395	RASPLPSGLLTPPQSGKKQSS	GSK-3_beta	14536078	LTP	1.00	MOD_GSK3_1	-	-	0.77	-	-

Substrate:

DRP-2 (Cytoskeletal associated protein)

Seq-ID:

Q16555 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-6826109 RK_BOVIN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
dihydropyrimidinase activity, protein binding	microtubule cytoskeleton	signal transduction, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	509	YDGPVCEVSVTPKTVTPASSA	GSK-3_beta	15466863	LTP	0.56		-	-	0.52	-	medium
T	514	CEVSVTPKTVTPASSAKTSPA	GSK-3_beta	15466863	LTP	0.67	MOD_GSK3_1	-	-	0.65	-	medium
T	514	CEVSVTPKTVTPASSAKTSPA	GSK-3_beta	15652488	LTP	0.67	MOD_GSK3_1	-	-	0.65	-	medium
S	518	VTPKTVTPASSAKTSPAKQQA	GSK-3_beta	15466863	LTP	0.72	MOD_GSK3_1	-	-	0.78	-	medium

Substrate:

DRP-3 (Dihydropyrimidinase related protein-3)

Seq-ID:

ENSP00000343690 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

Molecular Function	Cellular Component	Biological Process
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	623	YDGPVFDLTTTPKGGTPAGSA	GSK-3_beta	15466863	LTP	0.68		-	-	0.65	-	medium
T	628	FDLTTTPKGGTPAGSARGSPT	GSK-3_beta	15466863	LTP	0.75	MOD_GSK3_1	-	-	0.81	-	medium
S	632	TTPKGGTPAGSARGSPTRPNP	GSK-3_beta	15466863	LTP	0.74	MOD_GSK3_1	-	-	0.92	-	medium

Substrate:

Estrogen receptor alpha (Estrogen receptor (ER) (Estradiol receptor) (ER-alpha); nuclear hormone receptor. )

Seq-ID:

P03372 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13786   BRCA1_HUMAN
MINT-50646   STA5A_HUMAN
MINT-50709   M3K1_HUMAN
MINT-5222241   NCOA1_HUMAN
MINT-6169667   EGFR_HUMAN
MINT-6614126   SMCA4_HUMAN
MINT-6614301   CHD3_HUMAN
MINT-6614361   MTA1_HUMAN
MINT-6614421   MTA2_HUMAN
MINT-6761899   PTN1_HUMAN
MINT-6761906   PTN6_HUMAN
MINT-7013584   PA1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
beta-catenin binding, nitric-oxide synthase regulator activity, estrogen response element binding, steroid binding, zinc ion binding, sequence-specific DNA binding transcription factor activity, estrogen receptor activity	chromatin remodeling complex	response to estradiol stimulus, transcription, DNA-dependent, regulation of transcription, DNA-dependent, positive regulation of retinoic acid receptor signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	102	NGLGGFPPLNSVSPSPLMLLH	GSK-3_beta	16076840	LTP	0.85	MOD_GSK3_1	-	Oest_recep	0.46	-	-
S	104	LGGFPPLNSVSPSPLMLLHPP	GSK-3_beta	10949034	LTP	0.61	MOD_GSK3_1	-	Oest_recep	0.48	-	-
S	104	LGGFPPLNSVSPSPLMLLHPP	GSK-3_beta	16076840	LTP	0.61	MOD_GSK3_1	-	Oest_recep	0.48	-	-
S	106	GFPPLNSVSPSPLMLLHPPPQ	GSK-3_beta	16076840	LTP	0.96	MOD_GSK3_1	-	Oest_recep	0.52	-	-
S	118	LMLLHPPPQLSPFLQPHGQQV	GSK-3_beta	16076840	LTP	1.00	MOD_ProDKin_1	-	Oest_recep	0.50	-	-

Substrate:

glycogen synthase (Glycogen [starch] synthase, muscle)

Seq-ID:

P13807 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
glycogen (starch) synthase activity, protein binding		glycogen biosynthetic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	641	AQGYRYPRPASVPPSPSLSRH	GSK-3_beta	6772446	LTP	1.00	MOD_GSK3_1	-	Glycogen_syn	0.72	-	medium
S	645	RYPRPASVPPSPSLSRHSSPH	GSK-3_beta	6772446	LTP	1.00	MOD_GSK3_1	-	Glycogen_syn	0.82	-	medium
S	649	PASVPPSPSLSRHSSPHQSED	GSK-3_beta	6772446	LTP	1.00	MOD_GSK3_1	-	Glycogen_syn	0.90	-	medium

Substrate:

hnRPD (Ribonucleoprotein)

Seq-ID:

Q14103 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
nucleotide binding, transcription activator activity, telomeric DNA binding, RNA binding, protein binding	chromosome, heterogeneous nuclear ribonucleoprotein complex	transcription, regulation of transcription, DNA-dependent, RNA catabolic process, RNA splicing

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	83	NEEDEGHSNSSPRHSEAATAQ	GSK-3_beta	12819195	LTP	-	MOD_GSK3_1	-	-	0.92	-	-

Substrate:

IPP2 (protein phosphatase inhibitor 2 (IPP-2) (from PhosphoBase))

Seq-ID:

P41236 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine phosphatase inhibitor activity, protein binding		regulation of phosphoprotein phosphatase activity, regulation of signal transduction, glycogen metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	73	YGLMKIDEPSTPYHSMMGDDE	GSK-3_beta	12761178	LTP	1.00	MOD_GSK3_1	-	IPP-2	0.70	-	high

Substrate:

MCL1 (protein binding, protein channel activity)

Seq-ID:

Q07820 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-17381   B2L11_MOUSE
MINT-68750   HUWE1_HUMAN
MINT-68751   B2L11_HUMAN
MINT-4821036   BECN1_HUMAN
MINT-4980380   B2L11_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein heterodimerization activity, protein channel activity	integral to membrane, mitochondrial outer membrane, nucleoplasm	apoptosis, anti-apoptosis, cellular homeostasis, response to cytokine stimulus, cell fate determination, multicellular organismal development

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	159	ESGNNTSTDGSLPSTPPPAEE	GSK-3_beta	16543145	LTP	1.00	MOD_GSK3_1	-	-	0.96	-	low

Substrate:

Mdm2 (Ubiquitin-protein ligase E3 Mdm2 (EC 6.3.2. -) (p53-binding protein Mdm2) (Oncoprotein Mdm2) (Double minute 2 protein) (Hdm2))

Seq-ID:

P23804 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19799 ARRB1_HUMAN
MINT-7266318 PLK1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
p53 binding, ubiquitin-protein ligase activity	cytoplasm, nucleolus	traversing start control point of mitotic cell cycle, positive regulation of cell cycle

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	254	SVEFEVESLDSEDYSLSDEGH	GSK-3_beta	16055726	LTP	1.00	MOD_GSK3_1	-	-	0.58	-	medium

Substrate:

Microphthalmia-associated transcription factor (Transcription factor)

Seq-ID:

O75030-2 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription activator activity	nucleus	melanocyte differentiation, transcription

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	399	LEMQARAHGLSLIPSTGLCSP	GSK-3_beta	10587587	LTP	0.20	MOD_GSK3_1	-	-	0.40	-	medium

Substrate:

MKI67IP (protein binding, RNA binding)

Seq-ID:

Q9BYG3 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-50550 KI67_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
nucleotide binding, RNA binding, protein binding	condensed nuclear chromosome, cytoplasm, nucleolus, nucleoplasm	protein complex assembly, rRNA transcription, rRNA metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	230	TLDTPEKTVDSQGPTPVCTPT	GSK-3_beta	16244663	LTP	1.00	MOD_GSK3_1	-	-	0.68	-	medium
T	234	PEKTVDSQGPTPVCTPTFLER	GSK-3_beta	16244663	LTP	1.00	MOD_GSK3_1	MKI67 FHA	-	0.65	-	medium

Substrate:

Notch2 (Cell surface receptor)

Seq-ID:

O35516 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
receptor activity, calcium ion binding, protein binding	integral to plasma membrane, cell surface, nucleus	morphogenesis of an epithelial sheet, transcription, negative regulation of cell proliferation, cell cycle arrest, cell growth, positive regulation of Ras protein signal transduction, regulation of transcription, positive regulation of apoptosis, Notch signaling pathway, determination of left/right symmetry, regulation of developmental process, cell fate determination, embryonic limb morphogenesis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	2066	IVRLLDEYNVTPSPPGTVLTS	GSK-3_beta	12794074	LTP	0.00	MOD_GSK3_1	-	-	0.47	-	medium
S	2068	RLLDEYNVTPSPPGTVLTSAL	GSK-3_beta	12794074	LTP	1.00	MOD_GSK3_1	-	-	0.49	-	medium
T	2072	EYNVTPSPPGTVLTSALSPVL	GSK-3_beta	12794074	LTP	0.08	MOD_GSK3_1	-	-	0.52	-	medium
S	2091	VLCGPNRSFLSLKHTPMGKKA	GSK-3_beta	12794074	LTP	0.25	MOD_GSK3_1	-	-	0.55	-	medium

Substrate:

Nuclear factor NF-kappa-B p105 subunit (Nuclear factor NF-kappa-B p105 subunit)

Seq-ID:

P19838 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-47827   M3K8_HUMAN
MINT-47861   IKBB_HUMAN
MINT-48545   TPR_HUMAN
MINT-48546   KCRB_HUMAN
MINT-48547   CLH1_HUMAN
MINT-48555   VIME_HUMAN
MINT-48556   ADT3_HUMAN
MINT-48557   DESP_HUMAN
MINT-48560   JIP4_HUMAN
MINT-48561   COPB2_HUMAN
MINT-48636   BAG2_HUMAN
MINT-48638   NEMO_HUMAN
MINT-48639   HS71L_HUMAN
MINT-48640   GRP78_HUMAN
MINT-48641   HSP7C_HUMAN
MINT-48642   HNRPF_HUMAN
MINT-48643   IKKA_HUMAN
MINT-48644   ADT2_HUMAN
MINT-48645   GRP75_HUMAN
MINT-48646   RUVB2_HUMAN
MINT-48648   IMA3_HUMAN
MINT-48650   DNJA1_HUMAN
MINT-48651   IMA4_HUMAN
MINT-48653   C1QBP_HUMAN
MINT-48654   EF1A2_HUMAN
MINT-48655   MATR3_HUMAN
MINT-48656   IKBA_HUMAN
MINT-48659   MYH10_HUMAN
MINT-48660   PYR1_HUMAN
MINT-48663   ACTG_HUMAN
MINT-48665   STUB1_HUMAN
MINT-48666   REL_HUMAN
MINT-48669   TBB6_HUMAN
MINT-48670   CALM_HUMAN
MINT-48671   NONO_HUMAN
MINT-48672   TBB5_HUMAN
MINT-48673   TBB4_HUMAN
MINT-48675   K1967_HUMAN
MINT-48677   DNJA3_HUMAN
MINT-48678   MYH9_HUMAN
MINT-48679   RS8_HUMAN
MINT-48680   SFPQ_HUMAN
MINT-48682   HS90A_HUMAN
MINT-48684   PRKDC_HUMAN
MINT-48685   MYL6_HUMAN
MINT-48687   HNRPM_HUMAN
MINT-48688   HS90B_HUMAN
MINT-48689   ML12A_HUMAN
MINT-48724   NFKB2_HUMAN
MINT-48996   RELB_HUMAN
MINT-50169   HDAC1_HUMAN
MINT-7023862   CTNB1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
promoter binding, sequence-specific DNA binding transcription factor activity, protein binding	cytosol, I-kappaB/NF-kappaB complex, nucleoplasm	negative regulation of gene-specific transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter, positive regulation of transcription, negative regulation of cellular protein metabolic process, apoptosis, anti-apoptosis, negative regulation of cholesterol transport, membrane protein intracellular domain proteolysis, positive regulation of lipid storage, signal transduction, inflammatory response, positive regulation of macrophage derived foam cell differentiation, negative regulation of vitamin D biosynthetic process, negative regulation of calcidiol 1-monooxygenase activity

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	903	SPVKTTSQAHSLPLSPASTRQ	GSK-3_beta	12871932	LTP	-	MOD_GSK3_1	-	-	0.66	-	-
S	907	TTSQAHSLPLSPASTRQQIDE	GSK-3_beta	12871932	LTP	-	MOD_GSK3_1	-	-	0.62	-	-

Substrate:

p21 (Cyclin-dependent kinase inhibitor 1 (p21))

Seq-ID:

P38936 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-50392   CC45L_HUMAN
MINT-50407   CDC6_HUMAN
MINT-50418   CDK4_HUMAN
MINT-50421   CDK6_HUMAN
MINT-50432   CCNB2_HUMAN
MINT-50437   CCND1_HUMAN
MINT-50441   CCND3_HUMAN
MINT-50445   GEMI_HUMAN
MINT-50660   CCNB1_HUMAN
MINT-73322   VE7_HPV16
MINT-73323   CDK2_HUMAN
MINT-1774121   SKP2_HUMAN
MINT-1780042   MCM7_HUMAN
MINT-1891378   P53_HUMAN
MINT-2635177   CCNE1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cyclin-dependent protein kinase inhibitor activity, metal ion binding	cytosol, cyclin-dependent protein kinase holoenzyme complex, nucleoplasm, PCNA-p21 complex	cellular response to extracellular stimulus, positive regulation of fibroblast proliferation, senescence, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, negative regulation of cell proliferation, negative regulation of cell growth, cell cycle arrest, G1/S transition of mitotic cell cycle, induction of apoptosis by intracellular signals, Ras protein signal transduction, G2/M transition of mitotic cell cycle

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	57	ERWNFDFVTETPLEGDFAWER	GSK-3_beta	11779850	LTP	1.00	MOD_ProDKin_1	-	CDI	0.36	-	medium
S	114	GTAEEDHVDLSLSCTLVPRSG	GSK-3_beta	17283049	LTP	0.04	MOD_GSK3_1	-	-	0.49	-	medium

Substrate:

p65 (Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit), RelA)

Seq-ID:

Q04206 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-50016   IKBA_MOUSE
MINT-50017   IKBB_MOUSE
MINT-50025   KAPCA_HUMAN
MINT-50073   KS6A5_HUMAN
MINT-50084   KPCZ_HUMAN
MINT-50090   CSK21_HUMAN
MINT-50107   IKKA_HUMAN
MINT-50167   IKKB_HUMAN
MINT-50171   HDAC1_HUMAN
MINT-50175   KAT2B_HUMAN
MINT-50178   EP300_HUMAN
MINT-50179   HDAC3_HUMAN
MINT-58638   NCF1_HUMAN
MINT-62399   TF2B_HUMAN
MINT-2834593   NCOA3_HUMAN
MINT-6166971   OGT1_HUMAN
MINT-7235700   ASPP2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription repressor activity, transcription repressor binding, identical protein binding, protein kinase binding, ubiquitin protein ligase binding, transcription activator binding, transcription activator activity, RNA polymerase II transcription factor activity, enhancer binding, promoter binding, protein N-terminus binding, phosphate binding, NF-kappaB binding	cytosol, transcription factor complex	transcription, positive regulation of I-kappaB kinase/NF-kappaB cascade, cytokine-mediated signaling pathway, anti-apoptosis, defense response to virus, membrane protein intracellular domain proteolysis, cellular defense response, inflammatory response, nucleotide-binding oligomerization domain containing 2 signaling pathway, response to interleukin-1, interspecies interaction between organisms, positive regulation of NF-kappaB transcription factor activity, positive regulation of transcription from RNA polymerase II promoter, response to UV-B, negative regulation of gene-specific transcription

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	468	TDPAVFTDLASVDNSEFQQLL	GSK-3_beta	15465828	LTP	0.91	MOD_GSK3_1	-	-	0.53	-	-

Substrate:

Presenilin 1 (Presenilin 1 (PS-1) (S182 protein))

Seq-ID:

P49768 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14193   PKP4_HUMAN
MINT-15987   FLNB_HUMAN
MINT-16205   B2CL1_HUMAN
MINT-17726   FLNA_HUMAN
MINT-49819   CADH1_HUMAN
MINT-2837737   GSK3B_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium channel activity, beta-catenin binding, endopeptidase activity, PDZ domain binding	centrosome, Golgi membrane, smooth endoplasmic reticulum, integral to plasma membrane, cell surface, kinetochore, nuclear outer membrane, endoplasmic reticulum membrane, rough endoplasmic reticulum, gamma-secretase complex	induction of apoptosis by extracellular signals, membrane protein ectodomain proteolysis, anti-apoptosis, Notch receptor processing, membrane protein intracellular domain proteolysis, Notch signaling pathway, amyloid precursor protein catabolic process, cell-cell adhesion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	353	QRDSHLGPHRSTPESRAAVQE	GSK-3_beta	11104755	LTP	0.15	MOD_GSK3_1	-	PSN	0.59	-	medium
S	357	HLGPHRSTPESRAAVQELSSS	GSK-3_beta	11104755	LTP	0.93	MOD_GSK3_1	-	PSN	0.48	-	medium

Substrate:

PTEN (Lipid phosphatase)

Seq-ID:

P60484 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-63918   SCG1_HUMAN
MINT-63919   HBA_HUMAN
MINT-63921   UT14A_HUMAN
MINT-2832448   NHRF1_HUMAN
MINT-2832646   NHRF2_HUMAN
MINT-2832742   NHRF2_MOUSE
MINT-2832984   PGFRB_HUMAN
MINT-6793823   CAV1_HUMAN
MINT-7266561   PRDX1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity, protein tyrosine phosphatase activity, phosphatidylinositol-3-phosphatase activity, lipid binding, protein serine/threonine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity, phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity, enzyme binding, inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity, PDZ domain binding	cytosol, nucleus	protein stabilization, inositol phosphate dephosphorylation, central nervous system development, regulation of cyclin-dependent protein kinase activity, regulation of neuron projection development, apoptosis, positive regulation of transcription factor activity, protein amino acid dephosphorylation, canonical Wnt receptor signaling pathway, phosphoinositide dephosphorylation, negative regulation of cell migration, induction of apoptosis, negative regulation of focal adhesion assembly, negative regulation of protein kinase B signaling cascade, cell proliferation, negative regulation of protein amino acid phosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	362	EEPSNPEASSSTSVTPDVSDN	GSK-3_beta	16107342	LTP	0.79	MOD_GSK3_1	-	-	0.87	-	-
T	366	NPEASSSTSVTPDVSDNEPDH	GSK-3_beta	16107342	LTP	0.79	MOD_GSK3_1	-	-	0.83	-	-

Substrate:

Rap1GAP (GTPase activating protein)

Seq-ID:

P47736 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-3308267 1433Z_HUMAN
MINT-6543629 RAP1B_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein homodimerization activity, GTPase activator activity, Ras GTPase binding	Golgi membrane	signal transduction, regulation of Ras GTPase activity

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	525	SPPAGQKTPDSGHVSQEPKSE	GSK-3_beta	14660640	LTP	0.89	MOD_GSK3_1	-	-	0.95	-	low

Substrate:

SNAI1 (Transcription regulatory protein)

Seq-ID:

O95863 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-7384899   EGR1_HUMAN
MINT-7718917   P53_HUMAN
MINT-7718939   MDM2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
zinc ion binding, protein binding	cytoplasm, nucleus	mesoderm formation, epithelial to mesenchymal transition, positive regulation of epithelial to mesenchymal transition

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	104	EDSGKGSQPPSPPSPAPSSFS	GSK-3_beta	15647282	LTP	0.41	MOD_GSK3_1	-	-	0.89	-	low
S	107	GKGSQPPSPPSPAPSSFSSTS	GSK-3_beta	15647282	LTP	0.58	MOD_GSK3_1	-	-	0.82	-	low

Substrate:

tau (Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau))

Seq-ID:

P10636 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-49642   AATF_HUMAN
MINT-74874   KS6B1_HUMAN
MINT-3390085   KC1D_RAT
MINT-3974182   CDK5_HUMAN
MINT-3974216   GSK3B_HUMAN
MINT-7148384   EAA2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
apolipoprotein E binding, SH3 domain binding, lipoprotein binding, identical protein binding, structural constituent of cytoskeleton, enzyme binding, microtubule binding	plasma membrane, cytosol, microtubule associated complex, tubulin complex, axon, growth cone, microtubule	positive regulation of microtubule polymerization, superior temporal gyrus development, negative regulation of microtubule depolymerization, positive regulation of axon extension, microtubule cytoskeleton organization

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	548	REPKKVAVVRTPPKSPSSAKS	GSK-3_beta	9565682	LTP	1.00	MOD_GSK3_1	-	-	0.89	-	medium
S	552	KVAVVRTPPKSPSSAKSRLQT	GSK-3_beta	9565682	LTP	1.00	MOD_GSK3_1	-	-	0.87	-	medium
S	575	VPMPDLKNVKSKIGSTENLKH	GSK-3_beta	12714590	LTP	1.00	MOD_GSK3_1	-	Tubulin-binding	0.81	-	medium
S	579	DLKNVKSKIGSTENLKHQPGG	GSK-3_beta	12714590	LTP	1.00	MOD_GSK3_1	-	Tubulin-binding	0.83	-	medium
S	713	TDHGAEIVYKSPVVSGDTSPR	GSK-3_beta	9565682	LTP	1.00	MOD_GSK3_1	-	-	0.57	-	medium
S	721	YKSPVVSGDTSPRHLSNVSST	GSK-3_beta	9565682	LTP	1.00	MOD_GSK3_1	-	-	0.61	-	medium