Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

Substrate:

Band 3 anion transport protein (Anion exchange protein 1)

Seq-ID:

P02730 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-58445 CD2A1_HUMAN
MINT-6793324 PTN1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
inorganic anion exchanger activity, protein homodimerization activity, protein anchor, ankyrin binding	cortical cytoskeleton, basolateral plasma membrane, integral to plasma membrane	cellular ion homeostasis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	8	MEELQDDYEDMMEENLEQ	Lyn	10942405	LTP	0.00	Lyn SH2	-	0.80	-	-
Y	21	MMEENLEQEEYEDPDIPESQM	Lyn	10942405	LTP	0.79	Lyn SH2	-	0.89	-	-
Y	359	SSPAKPDSSFYKGLDLNGGPD	Lyn	10942405	LTP	0.11	PTPN11 SH2	-	0.45	-	-
Y	904	TFDEEEGRDEYDEVAMPV	Lyn	10942405	LTP	1.00	-	-	0.37	-	-

Substrate:

BTK (Bruton's tyrosine kinase)

Seq-ID:

Q06187 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-49799   IBTK_HUMAN
MINT-59463   BLNK_MOUSE
MINT-59465   BLNK_HUMAN
MINT-7230913   ARI3A_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphatidylinositol-3,4,5-trisphosphate binding, identical protein binding, metal ion binding, non-membrane spanning protein tyrosine kinase activity, ATP binding	plasma membrane, cytosol, nucleus, membrane raft	induction of apoptosis by extracellular signals, calcium-mediated signaling, mesoderm development

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	551	GLSRYVLDDEYTSSVGSKFPV	Lyn	8630736	LTP	1.00		-	TyrKc	0.10	1K2P	8.73%

Substrate:

Casein kinase II, alpha chain (casein kinase II, alpha chain (CKII) (EC 2.7.1.37) (from PhosphoBase))

Seq-ID:

P68400 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14550   ENPL_HUMAN
MINT-15215   UB2R1_HUMAN
MINT-15821   PIN1_HUMAN
MINT-17591   TCP4_HUMAN
MINT-50090   TF65_HUMAN
MINT-50947   1433B_HUMAN
MINT-51176   XRCC4_HUMAN
MINT-51183   XRCC1_HUMAN
MINT-62785   CSK2B_HUMAN
MINT-63998   ZHX1_HUMAN
MINT-1779097   KAP2_BOVIN
MINT-3372672   PACS1_HUMAN
MINT-3975397   1433S_HUMAN
MINT-4791613   HIF1A_HUMAN
MINT-4961111   KANK2_HUMAN
MINT-6628644   LT_SV40
MINT-6628799   VE7_HPV16
MINT-6744190   PTN1_HUMAN
MINT-6805408   MDC1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, ATP binding, protein N-terminus binding	plasma membrane, Sin3 complex, NuRD complex	protein amino acid phosphorylation, signal transduction, Wnt receptor signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	255	IAKVLGTEDLYDYIDKYNIEL	Lyn	12628006	LTP	0.49		-	S_TKc	0.09	3H30	17.90%

Substrate:

CD150 (T cell antigen receptor)

Seq-ID:

Q13291 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
antigen binding, transmembrane receptor activity	integral to membrane	positive regulation of cell proliferation, lymphocyte activation, interspecies interaction between organisms

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	327	SVQETNSITVYASVTLPES	Lyn	15315965	LTP	1.00		FGR SH2; INPP5D SH2; PTPN11 SH2; SH2D1A SH2; SH2D1B SH2	-	0.38	-	low

Substrate:

CD19 (Antigen of human B-lymphocytes)

Seq-ID:

P15391 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
receptor signaling protein activity, protein binding	integral to plasma membrane	cellular defense response

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	500	REATSLGSQSYEDMRGILYAA	Lyn	10933394	LTP	1.00		PIK3R1 SH2	-	0.73	-	medium
Y	531	GPNHEEDADSYENMDNPDGPD	Lyn	10933394	LTP	1.00		PIK3R1 SH2	-	0.97	-	medium

Substrate:

CD32 (CD antigen. Binds to the Fc region of immunoglobulins gamma.)

Seq-ID:

P12318 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
receptor activity, IgG binding	plasma membrane, integral to membrane

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	281	KRQLEETNNDYETADGGYMTL	Lyn	8756631	LTP	1.00		-	-	0.57	-	low
Y	288	NNDYETADGGYMTLNPRAPTD	Lyn	8756631	LTP	0.46	LIG_TYR_ITAM	-	-	0.66	-	low
Y	304	RAPTDDDKNIYLTLPPNDHVN	Lyn	8756631	LTP	0.08	LIG_TYR_ITAM	-	-	0.66	-	low

Substrate:

CD79A (B cell antigen receptor)

Seq-ID:

P11912 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transmembrane receptor activity	B cell receptor complex, external side of plasma membrane, integral to membrane, multivesicular body, membrane raft	B cell differentiation, B cell receptor signaling pathway, B cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	188	AGDEYEDENLYEGLNLDDCSM	Lyn	9531288	LTP	1.00	LIG_TYR_ITAM	BLK SH2; SHC1 SH2; SYK SH2	ITAM	0.35	-	low

Substrate:

CD79B (B cell antigen receptor)

Seq-ID:

P40259 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transmembrane receptor activity	integral to plasma membrane	immune response, cell surface receptor linked signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	196	SKAGMEEDHTYEGLDIDQTAT	Lyn	9531288	LTP	-	LIG_TYR_ITAM	BLK SH2	ITAM	0.48	-	medium
Y	207	EGLDIDQTATYEDIVTLRTGE	Lyn	9531288	LTP	-	LIG_TYR_ITAM	BLK SH2	ITAM	0.23	-	medium

Substrate:

Epo-R (Receptor for erythropoietin, a major activator of erythropoiesis)

Seq-ID:

P19235 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-73504   PTN6_HUMAN
MINT-74896   PTN6_MOUSE
MINT-6794748   PTN1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
erythropoietin receptor activity	extracellular region, integral to plasma membrane

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	368	PVGSEHAQDTYLVLDKWLLPR	Lyn	10579919	LTP	1.00		CISH SH2; INPP5D SH2; PLCG2 SH2; STAT5 SH2; SYK SH2	-	0.32	-	low

Substrate:

FCGR2B (protein binding)

Seq-ID:

P31994 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-74919   PTN6_HUMAN
MINT-74920   SHIP1_HUMAN
MINT-7245214   SRC_HUMAN
MINT-7247446   FYN_HUMAN
MINT-7251178   NCK1_HUMAN
MINT-7252786   PLCG1_HUMAN
MINT-7254142   CRK_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
receptor activity, IgG binding	plasma membrane, integral to membrane	immune response, interspecies interaction between organisms

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	292	DKVGAENTITYSLLMHPDALE	Lyn	8756631	LTP	1.00		INPP5D SH2; Lyn SH2; PIK3R1 SH2; PTPN11 SH2; PTPN6 SH2; SHC1 SH2	-	0.42	-	low

Substrate:

FCGR2C (transmembrane receptor activity)

Seq-ID:

P31995 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-7245226   SRC_HUMAN
MINT-7247458   FYN_HUMAN
MINT-7251190   NCK1_HUMAN
MINT-7252798   PLCG1_HUMAN
MINT-7254154   CRK_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transmembrane receptor activity, IgG binding	plasma membrane, cytoplasm, integral to membrane	immune response

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	310	RAPTDDDKNIYLTLPPNDHVN	Lyn	8756631	LTP	0.83	LIG_TYR_ITAM	-	-	0.67	-	medium

Substrate:

LckBP1 (Hematopoietic cell-specific LYN substrate 1)

Seq-ID:

P14317 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-61343   LYN_HUMAN
MINT-67768   SH24A_HUMAN
MINT-7971786   DLG4_RAT

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding transcription factor activity	mitochondrion, nucleus, membrane	intracellular signaling pathway, positive regulation of cell proliferation, response to hormone stimulus, erythrocyte differentiation, positive regulation of tyrosine phosphorylation of STAT protein, regulation of transcription, DNA-dependent

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	222	FNEMEAPTTAYKKTTPIEAAS	Lyn	10066823	LTP	1.00	-	HS1_rep	0.68	-	medium
Y	378	PEPEPEPENDYEDVEEMDRHE	Lyn	9104825	LTP	0.18	Lyn SH2	-	0.98	-	medium
Y	397	HEQEDEPEGDYEEVLEPEDSS	Lyn	9104825	LTP	0.80	Lyn SH2	-	0.95	-	medium

Substrate:

Leupaxin (may assemble and regulate leukocyte signalling complexes 2)

Seq-ID:

Q99N69 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
zinc ion binding	cytoplasm

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	72	YATNIQEPNVYSEVQEPKESV	Lyn	17640867	LTP	0.14		-	-	0.60	-	medium

Substrate:

Microtubule associated protein 2 (Cytoskeletal protein)

Seq-ID:

P11137 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-50652 FYN_HUMAN
MINT-50656 GRB2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
beta-dystroglycan binding, structural molecule activity, calmodulin binding	cytoplasm, microtubule associated complex, microtubule	negative regulation of microtubule depolymerization

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	67	AFGEHGSQGTYSNTKENGING	Lyn	15536091	LTP	1.00		GRB2 SH2	-	0.85	-	medium

Substrate:

NIPP1 (RNA binding protein)

Seq-ID:

Q12972 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-15257   CDC5L_HUMAN
MINT-62188   PP1A_HUMAN
MINT-64092   STC2_HUMAN
MINT-64094   SETB1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
DNA binding, protein serine/threonine phosphatase inhibitor activity, endonuclease activity, ribonuclease E activity, RNA binding, protein binding	spliceosomal complex, cytoplasm, nuclear speck	mRNA processing, transcription, regulation of transcription, RNA catabolic process, RNA splicing

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	264	MQNFAFSGGLYGGLPPTHSEA	Lyn	11104670	LTP	1.00		-	-	0.56	-	medium
Y	335	EAVNEPKKKKYAKEAWPGKKP	Lyn	11104670	LTP	1.00		-	-	0.70	-	medium

Substrate:

NMT1 (Unclassified)

Seq-ID:

P30419 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-1795337 CAN2_HUMAN
MINT-1795431 P53_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
glycylpeptide N-tetradecanoyltransferase activity	cytosol	protein lipoylation, N-terminal protein myristoylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	117	KTMEEASKRSYQFWDTQPVPK	Lyn	11594778	LTP	0.89		-	-	0.54	-	-
Y	180	KELYTLLNENYVEDDDNMFRF	Lyn	11594778	LTP	1.00		-	NMT	0.13	1RXT	25.33%

Substrate:

PAG1

Seq-ID:

Q3U1F9 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein binding	plasma membrane, integral to membrane, membrane raft	intracellular signaling pathway, negative regulation of T cell activation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	386	RRPSEEPEPDYEAIQTLNRED	Lyn	16920712	LTP	1.00		-	-	0.88	-	low
Y	414	NGHHVPKESDYESIGDLQQCR	Lyn	16920712	LTP	1.00		-	-	0.71	-	low

Substrate:

PKC delta (Protein kinase C, delta)

Seq-ID:

P28867 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein kinase C activity, metal ion binding, insulin receptor substrate binding, ATP binding	cytoplasm, membrane	protein amino acid phosphorylation, negative regulation of insulin receptor signaling pathway, negative regulation of peptidyl-tyrosine phosphorylation, interleukin-10 production, B cell proliferation, immunoglobulin mediated immune response, interleukin-12 production

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	52	KTLVQKKPTMYPEWKTTFDAH	Lyn	7575560	LTP	0.95	-	C2	0.32	-	low
Y	155	RGAIKQAKIHYIKNHEFIATF	Lyn	7575560	LTP	0.37	-	-	0.11	-	low
Y	565	FESIRVDTPHYPRWITKESKD	Lyn	7575560	LTP	1.00	-	S_TKc	0.26	-	low

Substrate:

PLC gamma 2 (Involved in transmembrane signaling)

Seq-ID:

P16885 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-60791   Z512B_HUMAN
MINT-74685   EGFR_HUMAN
MINT-74686   ERBB2_HUMAN
MINT-7252126   P85A_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphoinositide phospholipase C activity, signal transducer activity, protein binding	plasma membrane	phospholipid catabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	743	YPVTPELLERYNMERDINSLY	Lyn	12181444	LTP	0.05		-	-	0.27	-	medium

Substrate:

Protein disulfide-isomerase A3 precursor (Protein disulfide isomerase family)

Seq-ID:

P11598 [Rattus norvegicus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein disulfide isomerase activity	melanosome, endoplasmic reticulum lumen	cell redox homeostasis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	445	DATANDVPSPYEVKGFPTIYF	Lyn	8631326	LTP	0.32	-	Thioredoxin	0.36	-	low
Y	454	PYEVKGFPTIYFSPANKKLTP	Lyn	8631326	LTP	0.98	-	Thioredoxin	0.31	-	low
Y	467	PANKKLTPKKYEGGRELNDFI	Lyn	8631326	LTP	1.00	-	Thioredoxin	0.41	-	low

Substrate:

RGS16 (Regulator of G-protein signaling 16)

Seq-ID:

O15492 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
GTPase activator activity, calmodulin binding, signal transducer activity		negative regulation of signal transduction, visual perception, regulation of G-protein coupled receptor protein signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	177	SYPRFLKSPAYRDLAAQASAA	Lyn	12588871	LTP	1.00		Src SH2	RGS	0.29	2BT2	0.87%

Substrate:

STAT 5 (Transcription factor)

Seq-ID:

P42229 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-50646   ESR1_HUMAN
MINT-58264   STAP2_HUMAN
MINT-6793989   PTN1_HUMAN
MINT-7891339   EPOR_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium ion binding, sequence-specific DNA binding transcription factor activity, protein binding	cytoplasm, nucleus	valine metabolic process, oxaloacetate metabolic process, transcription, creatinine metabolic process, isoleucine metabolic process, JAK-STAT cascade, taurine metabolic process, allantoin metabolic process, fatty acid metabolic process, citrate metabolic process, 2-oxoglutarate metabolic process, succinate metabolic process, creatine metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	694	TPVLAKAVDGYVKPQIKQVVP	Lyn	11641791	LTP	0.25		CRKL SH2; PTPN11 SH2; STAT5 SH2	SH2	0.20	-	medium

Substrate:

SYK (Spleen tyrosine kinase )

Seq-ID:

P48025 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-56734 P85A_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
receptor signaling protein tyrosine kinase activity, non-membrane spanning protein tyrosine kinase activity, ATP binding	B cell receptor complex, cytoplasm	positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of interleukin-3 biosynthetic process, B cell receptor signaling pathway, serotonin secretion, positive regulation of alpha-beta T cell proliferation, positive regulation of calcium-mediated signaling, positive regulation of B cell differentiation, activation of JUN kinase activity, positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process, beta selection, positive regulation of gamma-delta T cell differentiation, positive regulation of mast cell degranulation, leukotriene biosynthetic process, protein amino acid autophosphorylation, enzyme linked receptor protein signaling pathway, peptidyl-tyrosine phosphorylation, positive regulation of alpha-beta T cell differentiation, G-protein coupled receptor protein signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	130	EDLKENLIREYVKQTWNLQGQ	Lyn	9820500	LTP	1.00	-	-	0.28	-	-
Y	317	RPESTVSFNPYEPTGGPWGPD	Lyn	9820500	LTP	1.00	CBL SH2	-	0.69	-	-
Y	342	REALPMDTEVYESPYADPEEI	Lyn	9820500	LTP	1.00	PLCG_group SH2; VAV1 SH2	-	0.58	-	-
Y	346	PMDTEVYESPYADPEEIRPKE	Lyn	9820500	LTP	1.00	PLCG_group SH2	-	0.54	-	-

Substrate:

Tyrosine-protein kinase Lyn (Tyr protein kinase family)

Seq-ID:

P07948 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-15243   SHC1_HUMAN
MINT-15994   HNRPK_RAT
MINT-16347   CBL_HUMAN
MINT-17535   KHDR1_HUMAN
MINT-17602   FAK1_HUMAN
MINT-48486   M3K3_HUMAN
MINT-50926   CIP4_HUMAN
MINT-61343   HCLS1_HUMAN
MINT-62784   CSK2B_HUMAN
MINT-2792057   PAK2_HUMAN
MINT-2792372   ADA15_HUMAN
MINT-7384444   ITB3_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
receptor signaling protein tyrosine kinase activity, non-membrane spanning protein tyrosine kinase activity, ATP binding, protein binding	plasma membrane, cytosol, Golgi apparatus, nucleus, perinuclear region of cytoplasm, membrane raft	positive regulation of cell proliferation, response to hormone stimulus, positive regulation of cellular component movement, positive regulation of stress-activated protein kinase signaling cascade, erythrocyte differentiation, positive regulation of tyrosine phosphorylation of STAT protein, interspecies interaction between organisms, response to DNA damage stimulus, peptidyl-tyrosine phosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	397	GLARVIEDNEYTAREGAKFPI	Lyn	8530369	LTP	0.86		-	TyrKc	0.16	-	medium

Substrate:

Tyrosine-protein kinase Lyn (Tyr protein kinase family)

Seq-ID:

P25911 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-58750   SKAP2_MOUSE
MINT-58751   FYB_MOUSE
MINT-58757   SRC8_MOUSE
MINT-58758   HCLS1_MOUSE
MINT-58759   BCAR1_MOUSE
MINT-58760   EFS_MOUSE
MINT-58761   IRS2_MOUSE
MINT-58762   DBNL_MOUSE
MINT-58763   DOK2_MOUSE
MINT-7137863   CRKL_HUMAN
MINT-7214337   PLCG2_MOUSE
MINT-7214388   P85A_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
SH3 domain binding, erythropoietin receptor binding, non-membrane spanning protein tyrosine kinase activity, ATP binding	Golgi apparatus, nucleus, perinuclear region of cytoplasm	intracellular signaling pathway, B cell receptor signaling pathway, hemoglobin biosynthetic process, signal transduction, neuron projection development, erythrocyte differentiation, positive regulation of tyrosine phosphorylation of STAT protein, protein amino acid autophosphorylation, peptidyl-tyrosine phosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	397	GLARVIEDNEYTAREGAKFPI	Lyn	10415030	LTP	0.88		-	TyrKc	0.16	-	-

Substrate:

Vanilloid receptor like channel 2 (Membrane transport protein)

Seq-ID:

Q9EPK8 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-4050151 ITCH_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
osmosensor activity, calcium channel activity, calmodulin binding	cilium, integral to membrane, adherens junction	vasopressin secretion, hyperosmotic salinity response, osmosensory signaling pathway, regulation of response to osmotic stress, cell-cell junction assembly

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	253	HIAIERRCKHYVELLVAQGAD	Lyn	12538589	LTP	0.17		-	ANK	0.13	-	low

Substrate:

Vanilloid receptor like channel 2 (Membrane transport protein)

Seq-ID:

Q9HBA0 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
identical protein binding, calcium channel activity, calmodulin binding	integral to membrane, adherens junction	cell volume homeostasis, osmosensory signaling pathway, cell-cell junction assembly, response to mechanical stimulus, elevation of cytosolic calcium ion concentration, cell death

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	253	HIAIERRCKHYVELLVAQGAD	Lyn	12538589	LTP	0.17		-	ANK	0.12	-	low