List of substrates found:


Substrate: Alpha-synuclein (Chaperone)
Seq-ID: P37840 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-2515544   VIME_HUMAN
MINT-3387974   TPPP_HUMAN
MINT-7555062   HSP71_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
histone binding,
ferrous iron binding,
phospholipase binding,
caspase inhibitor activity,
dynein binding,
alpha-tubulin binding,
zinc ion binding,
Hsp70 protein binding,
kinesin binding,
magnesium ion binding,
calcium ion binding,
tau protein binding		 plasma membrane,
cytosol,
nucleus,
axon,
actin cytoskeleton,
cell cortex,
growth cone,
fibril		 response to magnesium ion,
positive regulation of release of sequestered calcium ion into cytosol,
response to interferon-gamma,
regulation of phospholipase activity,
negative regulation of platelet-derived growth factor receptor signaling pathway,
positive regulation of inositol phosphate biosynthetic process,
response to interleukin-1,
response to iron(II) ion,
synaptic vesicle endocytosis,
negative regulation of monooxygenase activity,
positive regulation of receptor recycling,
response to lipopolysaccharide,
negative regulation of norepinephrine uptake,
negative regulation of exocytosis,
negative regulation of histone acetylation,
negative regulation of serotonin uptake,
receptor internalization,
cell death,
negative regulation of dopamine uptake,
negative regulation of transporter activity,
negative regulation of thrombin receptor signaling pathway,
positive regulation of endocytosis,
anti-apoptosis,
negative regulation of caspase activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 125 DMPVDPDNEAYEMPSEEGYQD SYK 11744621
LTP
0.26
 - Synuclein
0.82
 --
Y 133 EAYEMPSEEGYQDYEPEA    SYK 11744621
LTP
0.12
 - -
0.80
 --
Y 136 EMPSEEGYQDYEPEA       SYK 11744621
LTP
0.20
 - -
0.81
 --

Substrate: Band 3 anion transport protein (Anion exchange protein 1)
Seq-ID: P02730 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-58445   CD2A1_HUMAN
MINT-6793324   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
inorganic anion exchanger activity,
protein homodimerization activity,
protein anchor,
ankyrin binding		 cortical cytoskeleton,
basolateral plasma membrane,
integral to plasma membrane		 cellular ion homeostasis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 8    MEELQDDYEDMMEENLEQ SYK 10942405
LTP
0.00
 Lyn SH2 -
0.80
 --
Y 21 MMEENLEQEEYEDPDIPESQM SYK 10942405
LTP
0.79
 Lyn SH2 -
0.89
 --
Y 359 SSPAKPDSSFYKGLDLNGGPD SYK 10942405
LTP
0.11
 PTPN11 SH2 -
0.45
 --
Y 904 TFDEEEGRDEYDEVAMPV    SYK 10942405
LTP
1.00
 - -
0.37
 --

Substrate: BLNK (Adapter molecule)
Seq-ID: Q8WV28 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-59465   BTK_HUMAN
MINT-74486   ERBB2_HUMAN
MINT-6621148   KSYK_HUMAN
MINT-7144603   GRB2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3/SH2 adaptor activity,
transmembrane receptor protein tyrosine kinase adaptor protein activity		 plasma membrane,
cytoplasm		 B cell differentiation,
intracellular signaling pathway,
humoral immune response,
inflammatory response
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 72 EQWSDDFDSDYENPDEHSDSE SYK 12456653
LTP
1.00
 - -
0.81
 - low
Y 84 NPDEHSDSEMYVMPAEENADD SYK 12456653
LTP
1.00
 - -
0.86
 - low
Y 96 MPAEENADDSYEPPPVEQETR SYK 12456653
LTP
1.00
 - -
0.91
 - low
Y 178 PKGLLEDEADYVVPVEDNDEN SYK 9697839
LTP
1.00
 - -
0.80
 - low

Substrate: CBL E3 ubiquitin protein ligase (Adaptor molecule)
Seq-ID: P22681 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-15516   LCK_HUMAN
MINT-15716   CRK_HUMAN
MINT-16022   CD2AP_HUMAN
MINT-16347   LYN_HUMAN
MINT-16846   LCP2_HUMAN
MINT-17062   FCGR1_HUMAN
MINT-17932   NCK1_HUMAN
MINT-50666   FYN_HUMAN
MINT-50717   ABL1_HUMAN
MINT-50722   CRKL_HUMAN
MINT-58331   ITCH_HUMAN
MINT-60970   RET_HUMAN
MINT-60973   EGFR_HUMAN
MINT-60978   SHC1_HUMAN
MINT-68500   P85A_HUMAN
MINT-2837344   PLCG1_BOVIN
MINT-4299918   ASAP1_HUMAN
MINT-6169713   SPY1_HUMAN
MINT-6170244   SH3G2_HUMAN
MINT-6538940   SPY4_HUMAN
MINT-6538977   KSYK_HUMAN
MINT-6539587   MET_HUMAN
MINT-6539601   SPY2_HUMAN
MINT-6539646   VGFR1_HUMAN
MINT-6539679   RON_HUMAN
MINT-6539730   SRC_HUMAN
MINT-7040249   GRB2_HUMAN
MINT-7046364   ITSN1_HUMAN
MINT-7103623   MK08_HUMAN
MINT-7211864   ARHG7_HUMAN
MINT-7214822   FYN_MOUSE
MINT-7218352   SH3K1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
calcium ion binding,
zinc ion binding,
sequence-specific DNA binding transcription factor activity,
signal transducer activity,
ubiquitin-protein ligase activity		 cytosol,
nucleus		 epidermal growth factor receptor signaling pathway,
positive regulation of receptor-mediated endocytosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 700 EQCEGEEDTEYMTPSSRPLRP SYK 9525940
LTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 731 DCDQQIDSCTYEAMYNIQSQA SYK 9525940
LTP
0.29
 CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2		 -
0.47
 --
Y 774 PEESENEDDGYDVPKPPVPAV SYK 9525940
LTP
0.28
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.89
 --

Substrate: CD32 (CD antigen. Binds to the Fc region of immunoglobulins gamma.)
Seq-ID: P12318 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor activity,
IgG binding		 plasma membrane,
integral to membrane
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 281 KRQLEETNNDYETADGGYMTL SYK 8756631
LTP
1.00
 - -
0.57
 - low
Y 288 NNDYETADGGYMTLNPRAPTD SYK 8756631
LTP
0.46
 LIG_TYR_ITAM
 - -
0.66
 - low
Y 304 RAPTDDDKNIYLTLPPNDHVN SYK 8756631
LTP
0.08
 LIG_TYR_ITAM
 - -
0.66
 - low

Substrate: Dual specificity phosphatase 3 (Dual specificity phosphatase)
Seq-ID: P51452 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein tyrosine phosphatase activity,
protein tyrosine/serine/threonine phosphatase activity,
MAP kinase phosphatase activity		 cytosol,
immunological synapse,
nucleoplasm		 negative regulation of T cell activation,
inactivation of MAPK activity,
positive regulation of mitotic cell cycle,
negative regulation of T cell receptor signaling pathway,
peptidyl-tyrosine dephosphorylation,
negative regulation of JNK cascade,
negative regulation of ERK1 and ERK2 cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 138 YSRSPTLVIAYLMMRQKMDVK SYK 12447358
LTP
1.00
 - DSPc
0.17
 1VHR 3.93%

Substrate: FCGR2C (transmembrane receptor activity)
Seq-ID: P31995 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-7245226   SRC_HUMAN
MINT-7247458   FYN_HUMAN
MINT-7251190   NCK1_HUMAN
MINT-7252798   PLCG1_HUMAN
MINT-7254154   CRK_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transmembrane receptor activity,
IgG binding		 plasma membrane,
cytoplasm,
integral to membrane		 immune response
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 287 KRQPEETNNDYETADGGYMTL SYK 8756631
LTP
0.47
 - -
0.71
 - medium

Substrate: Integrin beta 3 (Platelet membrane glycoprotein IIIa)
Seq-ID: P05106 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-25081   ITAV_HUMAN
MINT-45900   EPS8_HUMAN
MINT-45905   RBGP1_HUMAN
MINT-45913   GULP1_HUMAN
MINT-45916   RGS12_HUMAN
MINT-45923   DAB1_MOUSE
MINT-45928   DAB2_MOUSE
MINT-45939   IRS1_RAT
MINT-45952   TLN1_MOUSE
MINT-45957   JIP1_HUMAN
MINT-45960   LIN10_CAEEL
MINT-61480   TENC1_HUMAN
MINT-61568   DOK1_MOUSE
MINT-61569   NUMB_MOUSE
MINT-1795026   TLN1_HUMAN
MINT-6794817   PTN1_HUMAN
MINT-7384376   SRC_MOUSE
MINT-7384444   LYN_HUMAN
MINT-7384460   YES_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor activity,
vascular endothelial growth factor receptor 2 binding,
identical protein binding,
platelet-derived growth factor receptor binding,
cell adhesion molecule binding		 integrin complex,
alphav-beta3 integrin-vitronectin complex,
platelet alpha granule membrane		 positive regulation of peptidyl-tyrosine phosphorylation,
positive regulation of endothelial cell proliferation,
regulation of bone resorption,
blood coagulation,
negative regulation of lipid transport,
tube development,
activation of protein kinase activity,
integrin-mediated signaling pathway,
positive regulation of vascular endothelial growth factor receptor signaling pathway,
negative regulation of lipid storage,
negative regulation of macrophage derived foam cell differentiation,
cell-matrix adhesion,
interspecies interaction between organisms,
smooth muscle cell migration,
negative regulation of lipoprotein metabolic process,
angiogenesis involved in wound healing,
positive regulation of endothelial cell migration,
negative regulation of low-density lipoprotein receptor biosynthetic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 785 EATSTFTNITYRGT        SYK 8631894
LTP
0.98
 PTPN11 SH2;
SHC1 PTB;
SYK SH2		 Integrin_b_cyt
0.26
 --

Substrate: LckBP1 (Hematopoietic cell-specific LYN substrate 1)
Seq-ID: P14317 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-61343   LYN_HUMAN
MINT-67768   SH24A_HUMAN
MINT-7971786   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
sequence-specific DNA binding transcription factor activity mitochondrion,
nucleus,
membrane		 intracellular signaling pathway,
positive regulation of cell proliferation,
response to hormone stimulus,
erythrocyte differentiation,
positive regulation of tyrosine phosphorylation of STAT protein,
regulation of transcription, DNA-dependent
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 378 PEPEPEPENDYEDVEEMDRHE SYK 9104825
LTP
0.18
 Lyn SH2 -
0.98
 - medium
Y 397 HEQEDEPEGDYEEVLEPEDSS SYK 9104825
LTP
0.80
 Lyn SH2 -
0.95
 - medium

Substrate: MAP4K1 (Hematopoietic progenitor kinase)
Seq-ID: Q92918 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-7212968   GRB2_HUMAN
MINT-7244806   ABL1_HUMAN
MINT-7245502   SRC_HUMAN
MINT-7246558   FYN_HUMAN
MINT-7249558   NCK1_HUMAN
MINT-7252330   P85A_HUMAN
MINT-7252558   PLCG1_HUMAN
MINT-7254804   CRK_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
MAP kinase kinase kinase kinase activity,
small GTPase regulator activity,
ATP binding,
protein binding		 activation of JUN kinase activity,
activation of MAPKKK activity,
peptidyl-serine phosphorylation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 381 KQLSESSDDDYDDVDIPTPAE SYK 11514608
LTP
0.04
 BLNK SH2 -
0.91
 - medium

Substrate: PKC alpha (Serine/threonine kinase)
Seq-ID: P17252 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-62532   RBP1_HUMAN
MINT-2490678   RAC1_HUMAN
MINT-2833162   BRAF_HUMAN
MINT-2833275   KPCE_HUMAN
MINT-2833291   KS6A2_HUMAN
MINT-3973484   NCF1_HUMAN
MINT-4298329   NUMB_DROME
MINT-4300836   INADL_HUMAN
MINT-4507294   JAK1_HUMAN
MINT-4507312   TYK2_HUMAN
MINT-4507332   IF2A_HUMAN
MINT-4507367   JAK2_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
histone kinase activity (H3-T6 specific),
ATP binding,
enzyme binding,
zinc ion binding		 plasma membrane,
cytosol,
endoplasmic reticulum		 induction of apoptosis by extracellular signals,
response to interleukin-1
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 658 IDQSDFEGFSYVNPQFVHPIL SYK 12881490
LTP
0.55
 - S_TK_X
0.23
 --

Substrate: PKC alpha (Serine/threonine kinase)
Seq-ID: P20444 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-4545254   CLOCK_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
calcium-dependent protein kinase C activity,
ATP binding,
zinc ion binding,
protein binding		 plasma membrane,
mitochondrion,
nucleus		 positive regulation of protein amino acid phosphorylation,
inactivation of MAPK activity,
negative regulation of insulin receptor signaling pathway,
negative regulation of cell proliferation,
negative regulation of glucose import,
cellular calcium ion homeostasis,
neutrophil chemotaxis,
positive regulation of inflammatory response,
regulation of muscle contraction,
induction of apoptosis by intracellular signals,
induction of positive chemotaxis,
regulation of the force of heart contraction,
regulation of peptidyl-tyrosine phosphorylation,
chondrocyte differentiation,
negative regulation of protein amino acid phosphorylation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 658 IDQSDFEGFSYVNPQFVHPIL SYK 12881490
LTP
0.55
 - S_TK_X
0.24
 - medium

Substrate: PLC gamma 1 (Major substrate for eparin binding growth factor)
Seq-ID: P19174 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19688   RBP2_MOUSE
MINT-74678   EGFR_HUMAN
MINT-74680   ERBB2_HUMAN
MINT-74682   ERBB3_HUMAN
MINT-7146767   AKT1_HUMAN
MINT-7229970   RAC1_HUMAN
MINT-7231507   PLD1_HUMAN
MINT-7252402   ICAL_HUMAN
MINT-7252438   TRAIP_HUMAN
MINT-7252450   SNX17_HUMAN
MINT-7252486   ASAP2_HUMAN
MINT-7252498   ARHGB_HUMAN
MINT-7252534   ASAP1_HUMAN
MINT-7252546   RRAS_HUMAN
MINT-7252558   M4K1_HUMAN
MINT-7252594   GHR_HUMAN
MINT-7252618   RGS7_HUMAN
MINT-7252642   CKAP5_HUMAN
MINT-7252666   JAK2_HUMAN
MINT-7252678   SOS1_HUMAN
MINT-7252690   FLNB_HUMAN
MINT-7252714   FLNA_HUMAN
MINT-7252738   ABL1_HUMAN
MINT-7252750   SUV92_HUMAN
MINT-7252762   SC24B_HUMAN
MINT-7252786   FCG2B_HUMAN
MINT-7252798   FCG2C_HUMAN
MINT-7252810   PHAR2_HUMAN
MINT-7252846   FANCA_HUMAN
MINT-7252858   TGON2_HUMAN
MINT-7252882   CAF1A_HUMAN
MINT-7252894   MAP4_HUMAN
MINT-7252954   SHAN2_HUMAN
MINT-7252966   DNLI3_HUMAN
MINT-7252978   NELFB_HUMAN
MINT-7253038   DTBP1_HUMAN
MINT-7253050   ABL2_HUMAN
MINT-7253062   AKAP2_HUMAN
MINT-7253086   FLNC_HUMAN
MINT-7253122   MINT_HUMAN
MINT-7253146   LIPA4_HUMAN
MINT-7253158   ADNP_HUMAN
MINT-7306637   LCP2_HUMAN
MINT-7309951   SCRB2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoinositide phospholipase C activity,
receptor signaling protein activity		 plasma membrane,
cytosol		 interspecies interaction between organisms,
phospholipid catabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 771 LEKIGTAEPDYGALYEGRNPG SYK 8657103
LTP
0.12
 - -
0.36
 - medium
Y 783 ALYEGRNPGFYVEANPMPTFK SYK 8657103
LTP
1.00
 - -
0.28
 - medium

Substrate: PYK2 (Focal adhesion kinase 2)
Seq-ID: Q14289 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-68515   PDC6I_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
signal transducer activity		 positive regulation of cell proliferation,
signal complex assembly,
apoptosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 402 SESCSIESDIYAEIPDETLRR SYK 8816475
LTP
1.00
 Fyn SH2;
MATK SH2;
Src SH2		 -
0.37
 --

Substrate: SH3 domain-binding protein 2 (Adaptor molecule)
Seq-ID: ENSMUSP00000098874 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 218 LSSYPMDNEDYEHEDEDDSYL SYK 12709437
LTP
1.00
 - -
0.72
 - medium
Y 227 DYEHEDEDDSYLEPDSPGPMK SYK 12709437
LTP
1.00
 - -
0.85
 - medium
Y 490 DTGEEDSDEDYEKVPLPNSVF SYK 12709437
LTP
1.00
 - -
0.70
 - medium

Substrate: Shc ( Adaptor molecule)
Seq-ID: P29353 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13959   DDR2_HUMAN
MINT-14688   GAB2_HUMAN
MINT-15243   LYN_HUMAN
MINT-15425   FYN_HUMAN
MINT-15946   FCGR1_HUMAN
MINT-16179   SHIP1_HUMAN
MINT-16513   LCP2_HUMAN
MINT-17269   SRC_CHICK
MINT-17501   P85A_HUMAN
MINT-49636   CADH5_HUMAN
MINT-49637   VGFR2_HUMAN
MINT-49660   A4_HUMAN
MINT-60978   CBL_HUMAN
MINT-60980   ZAP70_HUMAN
MINT-60981   RET_HUMAN
MINT-61536   ERBB4_HUMAN
MINT-61537   GRB2_HUMAN
MINT-74732   EGFR_HUMAN
MINT-74737   ERBB2_HUMAN
MINT-74738   ERBB3_HUMAN
MINT-1782423   SOS1_HUMAN
MINT-2738306   JAK2_MOUSE
MINT-7714840   IQGA1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
epidermal growth factor receptor binding,
insulin-like growth factor receptor binding,
insulin receptor binding,
phospholipid binding,
transmembrane receptor protein tyrosine kinase adaptor protein activity		 mitochondrial matrix,
Shc-EGFR complex,
cytosol		 positive regulation of DNA replication,
positive regulation of cell proliferation,
regulation of growth,
regulation of epidermal growth factor receptor activity,
epidermal growth factor receptor signaling pathway,
activation of MAPK activity,
Ras protein signal transduction,
insulin receptor signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 349 EEEEEPPDHQYYNDFPGKEPP SYK 9710204
LTP
1.00
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.86
 --
Y 350 EEEEPPDHQYYNDFPGKEPPL SYK 9710204
LTP
1.00
 GRB2 SH2;
INPP5D SH2		 -
0.85
 --
Y 427 PGRELFDDPSYVNVQNLDKAR SYK 9710204
LTP
0.99
 GRAP2 SH2;
GRB2 SH2;
INPP5D SH2		 -
0.62
 --

Substrate: SLP-76 (Adaptor molecule; involved in T cell AG receptor mediate signaling)
Seq-ID: Q13094 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-15244   FYB_HUMAN
MINT-16513   SHC1_HUMAN
MINT-16846   CBL_HUMAN
MINT-17488   FCGR1_HUMAN
MINT-59471   ITK_MOUSE
MINT-59473   ITK_HUMAN
MINT-59474   LCK_HUMAN
MINT-2837400   PLCG1_BOVIN
MINT-4302560   STAM1_HUMAN
MINT-4302608   STAM2_HUMAN
MINT-7041321   GRAP2_HUMAN
MINT-7306527   NCK1_HUMAN
MINT-7306585   SRC_CHICK
MINT-7306598   SRC_HUMAN
MINT-7306611   FYN_HUMAN
MINT-7306624   P85A_HUMAN
MINT-7306637   PLCG1_HUMAN
MINT-7306657   GRB2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein binding cytosol immune response,
transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 113 GGWSSFEEDDYESPNDDQDGE SYK 15388330
LTP
0.99
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.92
 - medium
Y 128 DDQDGEDDGDYESPNEEEEAP SYK 15388330
LTP
0.30
 ITK SH2;
NCK SH2;
PIK3R1 SH2;
PTPN6 SH2;
VAV1 SH2;
VAV_group SH2		 -
0.98
 - medium

Substrate: SYK (Spleen tyrosine kinase )
Seq-ID: P43405 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-56730   LCK_HUMAN
MINT-56732   P85A_HUMAN
MINT-56739   FGR_HUMAN
MINT-56749   P85B_HUMAN
MINT-74763   EGFR_HUMAN
MINT-74769   ERBB2_HUMAN
MINT-74775   ERBB3_HUMAN
MINT-74776   ERBB4_HUMAN
MINT-6538977   CBL_HUMAN
MINT-6621148   BLNK_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
integrin binding		 cytoplasm,
T cell receptor complex		 protein complex assembly,
organ morphogenesis,
integrin-mediated signaling pathway,
neutrophil chemotaxis,
interspecies interaction between organisms,
cell proliferation,
leukocyte cell-cell adhesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 348 REALPMDTEVYESPYADPEEI SYK 8657103
LTP
0.93
 FGR SH2;
Lck SH2;
PLCG1 SH2;
VAV1 SH2		 -
0.59
 --
Y 352 PMDTEVYESPYADPEEIRPKE SYK 8657103
LTP
1.00
 FGR SH2;
Lck SH2;
PLCG1 SH2;
VAV1 SH2		 -
0.53
 --
Y 525 LSKALRADENYYKAQTHGKWP SYK 8657103
LTP
1.00
 CBL PTB;
Lck SH2		 TyrKc
0.19
 1XBA 41.92%
Y 526 SKALRADENYYKAQTHGKWPV SYK 8657103
LTP
1.00
 CBL PTB;
Lck SH2		 TyrKc
0.17
 1XBA 30.57%

Substrate: SYK (Spleen tyrosine kinase )
Seq-ID: P48025 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-56734   P85A_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor signaling protein tyrosine kinase activity,
non-membrane spanning protein tyrosine kinase activity,
ATP binding		 B cell receptor complex,
cytoplasm		 positive regulation of peptidyl-tyrosine phosphorylation,
positive regulation of interleukin-3 biosynthetic process,
B cell receptor signaling pathway,
serotonin secretion,
positive regulation of alpha-beta T cell proliferation,
positive regulation of calcium-mediated signaling,
positive regulation of B cell differentiation,
activation of JUN kinase activity,
positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process,
beta selection,
positive regulation of gamma-delta T cell differentiation,
positive regulation of mast cell degranulation,
leukotriene biosynthetic process,
protein amino acid autophosphorylation,
enzyme linked receptor protein signaling pathway,
peptidyl-tyrosine phosphorylation,
positive regulation of alpha-beta T cell differentiation,
G-protein coupled receptor protein signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 130 EDLKENLIREYVKQTWNLQGQ SYK 9820500
LTP
1.00
 - -
0.28
 --
Y 342 REALPMDTEVYESPYADPEEI SYK 8657103
LTP
1.00
 PLCG_group SH2;
VAV1 SH2		 -
0.58
 --
Y 346 PMDTEVYESPYADPEEIRPKE SYK 8657103
LTP
1.00
 PLCG_group SH2 -
0.54
 --
Y 358 DPEEIRPKEVYLDRSLLTLED SYK 8657103
LTP
0.16
 - -
0.44
 1XBA 68.12%
Y 519 LSKALRADENYYKAQTHGKWP SYK 8657103
LTP
1.00
 - TyrKc
0.19
 1XBA 41.92%
Y 520 SKALRADENYYKAQTHGKWPV SYK 8657103
LTP
1.00
 - TyrKc
0.17
 1XBA 30.57%

Substrate: TUBA1A (Structural protein)
Seq-ID: P68369 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
GTPase activity,
GTP binding,
structural molecule activity		 microtubule protein polymerization,
microtubule-based movement
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 432 REDMAALEKDYEEVGVDSVEG SYK 8566014
LTP
0.97
 Fyn SH2 -
0.47
 1SA0 0.44%

Substrate: TYRO protein tyrosine kinase-binding protein precursor (Cell surface receptor)
Seq-ID: O43914 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor signaling protein activity,
protein binding		 integral to plasma membrane intracellular signaling pathway,
cellular defense response
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 91 KQRITETESPYQELQGQRSDV SYK 9490415
LTP
1.00
 - -
0.52
 - low
Y 102 QELQGQRSDVYSDLNTQRPYY SYK 9490415
LTP
1.00
 - -
0.41
 - low

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