List of substrates found:


Substrate: ARHGDIA (protein binding, Rho GDP-dissociation inhibitor activity)
Seq-ID: P52565 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 101 TGDLESFKKQSFVLKEGVEYR PAK1 15225553
LTP
0.57
- Rho_GDI
0.22
1KMT 40.98%
S 174 EAPKGMLARGSYSIKSRFTDD PAK1 15225553
LTP
0.58
- Rho_GDI
0.35
1KMT 58.20%

Substrate: B-Raf (B-Raf proto-oncogene serine/threonine-protein kinase)
Seq-ID: P15056 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 446 NRMKTLGRRDSSDDWEIPDGQ PAK1 15710605
LTP
1.00
- -
0.65
--

Substrate: BAD (Bcl2-antagonist of cell death (BAD) (Bcl-2 binding component 6) (Bcl- XL/Bcl-2 associated death promoter) (Bcl-2-like 8 protein))
Seq-ID: Q92934 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 99 EPSPFRGRSRSAPPNLWAAQR PAK1 10611223
LTP
1.00
MOD_PKB_1
- Bcl-2_BAD
0.76
- medium

Substrate: CPI-17 (Inhibitor of PPP1CA)
Seq-ID: Q91VC7 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoprotein phosphatase inhibitor activity cytoplasm regulation of phosphorylation
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 38 SGLQKRHARVTVKYDRRELQR PAK1 12359219
LTP
1.00
- PP1_inhibitor
0.51
- low

Substrate: Dynein light chain 1, cytoplasmic (Motor activity)
Seq-ID: P63168 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 88 LGQVAILLFKSG          PAK1 15504720
LTP
0.00
- Dynein_light
0.02
1CMI 32.79%

Substrate: Estrogen receptor alpha (Estrogen receptor (ER) (Estradiol receptor) (ER-alpha); nuclear hormone receptor. )
Seq-ID: P03372 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 305 PLMIKRSKKNSLALSLTADQM PAK1 12374744
LTP
0.93
- -
0.31
2QA8 64.75%

Substrate: Filamin A (Anchor protein)
Seq-ID: P21333 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 2152 ESITRRRRAPSVANVGSHCDL PAK1 12198493
LTP
0.88
- IG_FLMN
0.48
2J3S 66.39%

Substrate: Forkhead box protein L2 (Transcription regulatory protein)
Seq-ID: P58012 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 263 ASYGPYTRVQSMALPPGVVNS PAK1 12560069
LTP
0.26
- -
0.40
- medium

Substrate: Gz-alpha (G protein)
Seq-ID: P19086 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 16 SSEEKEAARRSRRIDRHLRSE PAK1 10531372
LTP
1.00
- G_alpha
0.65
- medium

Substrate: Gz-alpha (G protein)
Seq-ID: ENSP00000248996 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
GTP binding,
signal transducer activity
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 16 SSEEKEAARRSRRIDRHLRSE PAK1 10531372
LTP
- - G_alpha
0.65
- medium

Substrate: LIM domain kinase 1 (Serine/threonine kinase)
Seq-ID: P53667 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 508 LKKPDRKKRYTVVGNPYWMAP PAK1 10559936
LTP
1.00
- STYKc
0.29
- medium

Substrate: MAP2K1 (Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.1.-) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1))
Seq-ID: Q02750 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 298 PRPRTPGRPLSSYGMDSRPPM PAK1 12876277
LTP
0.74
- S_TKc
0.69
--
S 298 PRPRTPGRPLSSYGMDSRPPM PAK1 9351825
LTP
0.74
- S_TKc
0.69
--
S 298 PRPRTPGRPLSSYGMDSRPPM PAK1 16129686
LTP
0.74
- S_TKc
0.69
--
S 298 PRPRTPGRPLSSYGMDSRPPM PAK1 14993270
LTP
0.74
- S_TKc
0.69
--

Substrate: Mitogen-activated protein kinase kinase kinase 1 (Ser/Thr protein kinase family. MAP kinase family)
Seq-ID: Q62925 [Rattus norvegicus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 67 WRRQQLRKVRSVELDQLPEQP PAK1 12228228
LTP
0.95
- -
0.78
- low

Substrate: PGM1 (phosphoglucomutase activity)
Seq-ID: P36871 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
magnesium ion binding,
phosphoglucomutase activity
cytosol glucose metabolic process
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 467 KQFSANDKVYTVEKADNFEYS PAK1 15378030
LTP
0.27
- PGM_PMM_IV
0.26
- medium

Substrate: Phosphoglycerate mutase 1 (Phosphoglycerate mutase)
Seq-ID: P18669 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 23 ESAWNLENRFSGWYDADLSPA PAK1 12189148
LTP
0.21
- PGAM
0.22
1YFK 9.84%
S 118 GEAQVKIWRRSYDVPPPPMEP PAK1 12189148
LTP
1.00
- PGAM
0.50
1YFK 20.49%

Substrate: Protein phosphatase 1, regulatory subunit 12A (Myosin phosphatase target subunit 1)
Seq-ID: Q10728 [Rattus norvegicus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoprotein phosphatase activity,
protein binding
cytoplasm
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 697 SRQARQSRRSTQGVTLTDLQE PAK1 12359219
LTP
1.00
- -
0.78
- medium

Substrate: Raf1 (RAF proto-oncogene serine/threonine-protein kinase)
Seq-ID: P04049 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 338 NKIRPRGQRDSSYYWEIEASE PAK1 11733498
LTP
0.96
- -
0.43
- medium
S 338 NKIRPRGQRDSSYYWEIEASE PAK1 10801448
LTP
0.96
- -
0.43
- medium
S 339 KIRPRGQRDSSYYWEIEASEV PAK1 15849194
LTP
0.93
- -
0.41
- medium

Substrate: Rho/Rac guanine nucleotide exchange factor 2 (Stimulates guanine nucleotide exchange of Rac and Rho)
Seq-ID: ENSP00000357298 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 887 ARRPVDPRRRSLPAGDALYLS PAK1 14970201
LTP
0.09
- -
0.64
- medium

Substrate: Rho/Rac guanine nucleotide exchange factor 2 (Stimulates guanine nucleotide exchange of Rac and Rho)
Seq-ID: Q92974 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 885 ARRPVDPRRRSSPQAMPCT   PAK1 14970201
LTP
0.00
- -
0.83
- low

Substrate: SNAI1 (Transcription regulatory protein)
Seq-ID: O95863 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 246 YQCQACARTFSRMSLLHKHQE PAK1 15833848
LTP
1.00
- ZnF_C2H2
0.11
- low

Substrate: STAT 5 (Transcription factor)
Seq-ID: P42230 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
sequence-specific DNA binding transcription factor activity,
signal transducer activity,
protein binding,
calcium ion binding
cytoplasm,
nucleus
valine metabolic process,
positive regulation of mast cell proliferation,
oxaloacetate metabolic process,
creatinine metabolic process,
isoleucine metabolic process,
cytokine-mediated signaling pathway,
positive regulation of mitotic cell cycle,
positive regulation of B cell differentiation,
lipid storage,
taurine metabolic process,
allantoin metabolic process,
fatty acid metabolic process,
Peyer`s patch development,
positive regulation of interleukin-2 biosynthetic process,
development of secondary male sexual characteristics,
citrate metabolic process,
lactation,
female pregnancy,
JAK-STAT cascade involved in growth hormone signaling pathway,
T cell homeostasis,
peptidyl-tyrosine phosphorylation,
2-oxoglutarate metabolic process,
development of secondary female sexual characteristics,
negative regulation of erythrocyte differentiation,
luteinization,
positive regulation of transcription from RNA polymerase II promoter,
regulation of cell adhesion,
succinate metabolic process,
T cell differentiation in the thymus,
creatine metabolic process,
natural killer cell differentiation,
positive regulation of mast cell differentiation,
positive regulation of activated T cell proliferation,
transcription,
prostate gland epithelium morphogenesis,
positive regulation of natural killer cell differentiation,
regulation of steroid metabolic process,
epithelial cell differentiation involved in prostate gland development,
positive regulation of survival gene product expression,
positive regulation of gamma-delta T cell differentiation,
positive regulation of natural killer cell mediated cytotoxicity,
regulation of epithelial cell differentiation,
positive regulation of inflammatory response,
negative regulation of mast cell apoptosis,
positive regulation of multicellular organism growth
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 779 RPMDSLDARLSPPAGLFTSAR PAK1 12732616
LTP
0.76
- -
0.50
--

Substrate: Stathmin (stathmin (phosphoprotein p19) (oncoprotein 18) (Op18) (from PhosphoBase))
Seq-ID: P16949 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 16 IQVKELEKRASGQAFELILSP PAK1 7925472
LTP
1.00
- Stathmin
0.46
- medium

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