Phospho.ELM Currently 19650 Instances in Phospho.ELM database.

List of substrates found:

Vav  Estrogen receptor alpha  IKB-alpha  CD28  CTLA-4  IL-2R beta  PKC delta  CD31  PTEN  CD33  LAMP  ZAP70  CBL E3 ubiquitin protein ligase  Vav 2  Shc  SIGLEC10  LCK  PKC theta  Tyrosine-protein phosphatase, non-receptor type 6  PLC gamma 2  Spectrin  DAPP1  LNK  ITK  SOCS3  Erzin  CD5  CD150 

Substrate
Short Description
UniPROT/Ensembl Id
Species
Interaction Network
Position
Sequence
Kinase
PubMed
Source
Phospho-peptide
Binding Domain
Smart/Pfam
ELM
PDB/MSD
Adaptor molecule. GDP/GTP exchange factor in Rho/Rac molecule
Mus musculus
Y142
EDSALNDEDIYSGLSDQIDDT
Lck
10669745
LTP
-
-
-
-
     
Y160
DDTAEEDEDLYDCVENEEAEG
Lck
10669745
LTP
-
-
-
-
     
Y174
ENEEAEGDEIYEDLMRLESVP
Lck
10669745
LTP
-
-
-
-
             
Adaptor molecule. GDP/GTP exchange factor in Rho/Rac molecule
Homo sapiens
Y142
EEESVGDEDIYSGLSDQIDDT
Lck
16285729
LTP
-
-
-
-
     
Y160
DDTVEEDEDLYDCVENEEAEG
Lck
16285729
15699036
LTP
-
-
-
-
     
Y174
ENEEAEGDEIYEDLMRSEPVS
Lck
898671
10669745
LTP
PTPN6 SH2
-
-
-
             
 
Substrate
Short Description
UniPROT/Ensembl Id
Species
Interaction Network
Position
Sequence
Kinase
PubMed
Source
Phospho-peptide
Binding Domain
Smart/Pfam
ELM
PDB/MSD
Estrogen receptor (ER) (Estradiol receptor) (ER-alpha); nuclear hormone receptor.
Homo sapiens
Y537
SMKCKNVVPLYDLLLEMLDAH
Lck;
Src
7539106
LTP
-
-
-
1r5k
3erd
3ert
1a52
1zky
             
 
Substrate
Short Description
UniPROT/Ensembl Id
Species
Interaction Network
Position
Sequence
Kinase
PubMed
Source
Phospho-peptide
Binding Domain
Smart/Pfam
ELM
PDB/MSD
Major histocompatibility complex enhancer-binding protein MAD3
Homo sapiens
Y42
SGLDSMKDEEYEQMVKELQEI
Lck;
Src
8797825
12432072
9792645
LTP
-
-
-
-
             
 
Substrate
Short Description
UniPROT/Ensembl Id
Species
Interaction Network
Position
Sequence
Kinase
PubMed
Source
Phospho-peptide
Binding Domain
Smart/Pfam
ELM
PDB/MSD
Involved in T cell activation
Homo sapiens
Y191
SKRSRLLHSDYMNMTPRRPGP
Lck;
ITK
8992971
16094384
HTP/LTP
GRB2 SH2;
PIK3R1 SH2
-
-
-
             
 
Substrate
Short Description
UniPROT/Ensembl Id
Species
Interaction Network
Position
Sequence
Kinase
PubMed
Source
Phospho-peptide
Binding Domain
Smart/Pfam
ELM
PDB/MSD
CD152 antigen
Mus musculus
-
Y201
KKRSPLTTGVYVKMPPTEPEC
Lck;
JAK2
10842319
9973379
LTP
-
-
-
-
     
Y218
EPECEKQFQPYFIPIN
Lck
9973379
LTP
-
-
-
-
             
 
Substrate
Short Description
UniPROT/Ensembl Id
Species
Interaction Network
Position
Sequence
Kinase
PubMed
Source
Phospho-peptide
Binding Domain
Smart/Pfam
ELM
PDB/MSD
Cytokin receptor
Homo sapiens
Y381
DALEIEACQVYFTYDPYSEED
Lck
10214954
2047859
LTP
-
-
-
-
     
Y384
EIEACQVYFTYDPYSEEDPDE
Lck
10214954
2047859
LTP
-
-
-
-
     
Y387
ACQVYFTYDPYSEEDPDEGVA
Lck
10214954
2047859
LTP
-
-
-
-
     
Y418
LQPLSGEDDAYCTFPSRDDLL
Lck
10214954
LTP
STAT5 SH2
-
-
-
     
Y536
NARLPLNTDAYLSLQELQGQD
Lck
10214954
LTP
STAT5 SH2
-
-
-
             
 
Substrate
Short Description
UniPROT/Ensembl Id
Species
Interaction Network
Position
Sequence
Kinase
PubMed
Source
Phospho-peptide
Binding Domain
Smart/Pfam
ELM
PDB/MSD
Protein kinase C, delta
Mus musculus
Y311
KLDTTESVGIYQGFEKKPEVS
Lck
11381116
19144319
HTP/LTP
-
-
-
-
             
 
Substrate
Short Description
UniPROT/Ensembl Id
Species
Interaction Network
Position
Sequence
Kinase
PubMed
Source
Phospho-peptide
Binding Domain
Smart/Pfam
ELM
PDB/MSD
Adhesion molecule
Mus musculus
-
Y679
NKDPQNMDVEYTEVEVSSLEP
Lck
9624175
LTP
-
-
-
-
             
 
Substrate
Short Description
UniPROT/Ensembl Id
Species
Interaction Network
Position
Sequence
Kinase
PubMed
Source
Phospho-peptide
Binding Domain
Smart/Pfam
ELM
PDB/MSD
Lipid phosphatase
Homo sapiens
Y240
GPTRREDKFMYFEFPQPLPVC
Lck
11948419
LTP
-
-
-
-
     
Y315
SIERADNDKEYLVLTLTKNDL
Lck
11948419
LTP
-
-
-
-
             
 
Substrate
Short Description
UniPROT/Ensembl Id
Species
Interaction Network
Position
Sequence
Kinase
PubMed
Source
Phospho-peptide
Binding Domain
Smart/Pfam
ELM
PDB/MSD
CD antigen
Homo sapiens
Y340
PTVEMDEELHYASLNFHGMNP
Lck;
Src
10206955
10887109
LTP
-
-
-
-
             
 
Substrate
Short Description
UniPROT/Ensembl Id
Species
Interaction Network
Position
Sequence
Kinase
PubMed
Source
Phospho-peptide
Binding Domain
Smart/Pfam
ELM
PDB/MSD
Unclassified
Human herpesvirus 8
-
Y480
QAATQPTDDLYEEVLFPRN
Fyn;
Lck;
Yes;
HCK
12915550
LTP
-
-
-
-
             
 
Substrate
Short Description
UniPROT/Ensembl Id
Species
Interaction Network
Position
Sequence
Kinase
PubMed
Source
Phospho-peptide
Binding Domain
Smart/Pfam
ELM
PDB/MSD
Cytoplasmic tyrosine kinase
Homo sapiens
Y292
RRIDTLNSDGYTPEPARITSP
Lck;
ZAP70
8756661
7961936
15144186
15592455
16094384
15659558
17192257
HTP/LTP
CBL SH2
-
-
-
     
Y474
ARNVLLVNRHYAKISDFGLSK
Lck
9685404
LTP
SHC_group SH2
TyrKc
-
-
     
Y492
LSKALGADDSYYTARSAGKWP
Lck;
ZAP70
8756661
7961936
7642520
12522270
15592455
11270871
16094384
15659558
17192257
HTP/LTP
-
TyrKc
-
-
     
Y493
SKALGADDSYYTARSAGKWPL
Lck;
ZAP70
8756661
7961936
7642520
12522270
15144186
15592455
11270871
16094384
15659558
HTP/LTP
-
TyrKc
-
-
             
 
Substrate
Short Description
UniPROT/Ensembl Id
Species
Interaction Network
Position
Sequence
Kinase
PubMed
Source
Phospho-peptide
Binding Domain
Smart/Pfam
ELM
PDB/MSD
Adaptor molecule
Homo sapiens
Y700
EQCEGEEDTEYMTPSSRPLRP
Fyn;
Lck;
Abl;
Syk;
Yes;
InsR
9525940
9102067
12522270
11997497
10829062
HTP/LTP
CRK SH2;
VAV_group SH2
-
-
-
     
Y731
DCDQQIDSCTYEAMYNIQSQA
Fyn;
Lck;
Syk;
Src;
Yes;
HCK
9525940
10934191
9890970
12604776
LTP
PIK3R1 SH2
-
-
-
     
Y774
PEESENEDDGYDVPKPPVPAV
Fyn;
Lck;
Abl;
Syk;
Src;
InsR
9525940
12522270
12604776
10829062
HTP/LTP
CRKL SH2
-
-
-
             
 
Substrate
Short Description
UniPROT/Ensembl Id
Species
Interaction Network
Position
Sequence
Kinase
PubMed
Source
Phospho-peptide
Binding Domain
Smart/Pfam
ELM
PDB/MSD
Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases
Homo sapiens
Y142
EETTENDDDVYRSLEELADEH
Lck;
EGFR
12454019
LTP
-
-
-
-
     
Y159
ADEHDLGEDIYDCVPCEDGGD
Lck;
EGFR
12454019
LTP
-
-
-
-
     
Y172
VPCEDGGDDIYEDIIKVEVQQ
Lck;
EGFR
12454019
LTP
-
-
-
-
             
 
Substrate
Short Description
UniPROT/Ensembl Id
Species
Interaction Network
Position
Sequence
Kinase
PubMed
Source
Phospho-peptide
Binding Domain
Smart/Pfam
ELM
PDB/MSD
Adaptor molecule
Homo sapiens
Y427
PGRELFDDPSYVNVQNLDKAR
Fyn;
Lck;
InsR;
PDGFR_group;
FLT4
11075717
9710204
8610109
9741627
12522270
15592455
9927207
HTP/LTP
GRB2 SH2
-
-
-
             
 
Substrate
Short Description
UniPROT/Ensembl Id
Species
Interaction Network
Position
Sequence
Kinase
PubMed
Source
Phospho-peptide
Binding Domain
Smart/Pfam
ELM
PDB/MSD
cell adhesion molecule
Homo sapiens
Y597
RFSRHSTILDYINVVPTAGPL
Lck;
JAK3;
ITK
11733002
LTP
-
-
-
-
     
Y667
ESQESQEELHYATLNFPGVRP
Lck;
JAK3;
ITK
11733002
LTP
-
-
-
-
     
Y691
ARMPKGTQADYAEVKFQ
Lck;
JAK3
11733002
LTP
-
-
-
-
             
 
Substrate
Short Description
UniPROT/Ensembl Id
Species
Interaction Network
Position
Sequence
Kinase
PubMed
Source
Phospho-peptide
Binding Domain
Smart/Pfam
ELM
PDB/MSD
proto-oncogene tyrosine-protein kinase Lck (from PhosphoBase)
Homo sapiens
Y394
GLARLIEDNEYTAREGAKFPI
Lck
3265417
15592455
15659558
17192257
HTP/LTP
-
TyrKc
-
-
     
Y505
EDFFTATEGQYQPQP
Lck
3265417
15592455
8945479
17192257
HTP/LTP
-
-
-
-
             
 
Substrate
Short Description
UniPROT/Ensembl Id
Species
Interaction Network
Position
Sequence
Kinase
PubMed
Source
Phospho-peptide
Binding Domain
Smart/Pfam
ELM
PDB/MSD
Serine/threonine kinase
Homo sapiens
Y90
DLISETTVELYSLAERCRKNN
Lck
10652356
LTP
-
-
-
2fk9
             
 
Substrate
Short Description
UniPROT/Ensembl Id
Species
Interaction Network
Position
Sequence
Kinase
PubMed
Source
Phospho-peptide
Binding Domain
Smart/Pfam
ELM
PDB/MSD
Protein tyrosine phosphatase containing SH2 domains
Homo sapiens
Y536
LQSQKGQESEYGNITYPPAMK
Lck;
Src
12468540
8114715
8692915
7512963
14757045
14699166
LTP
-
-
-
-
     
Y564
RTSSKHKEDVYENLHTKNKRE
Lck;
Src
12468540
8114715
8692915
14757045
14699166
10488096
LTP
-
-
-
-
             
 
Substrate
Short Description
UniPROT/Ensembl Id
Species
Interaction Network
Position
Sequence
Kinase
PubMed
Source
Phospho-peptide
Binding Domain
Smart/Pfam
ELM
PDB/MSD
Involved in transmembrane signaling
Homo sapiens
Y743
YPVTPELLERYNMERDINSLY
Fyn;
Lck;
Lyn
12181444
LTP
-
-
-
-
     
Y753
YNMERDINSLYDVSRMYVDPS
Fyn;
Lck;
Lyn;
Src;
BTK
11507089
11606584
12181444
15144186
HTP/LTP
-
-
-
-
     
Y759
INSLYDVSRMYVDPSEINPSM
Fyn;
Lck;
Lyn;
Src;
BTK
11507089
11606584
12181444
14656219
LTP
-
-
-
-
             
 
Substrate
Short Description
UniPROT/Ensembl Id
Species
Interaction Network
Position
Sequence
Kinase
PubMed
Source
Phospho-peptide
Binding Domain
Smart/Pfam
ELM
PDB/MSD
Cytoskeletal protein
Homo sapiens
Y1176
EVQAVQQQEVYGMMPRDETDS
Lck;
Src
11971983
LTP
-
-
-
-
             
 
Substrate
Short Description
UniPROT/Ensembl Id
Species
Interaction Network
Position
Sequence
Kinase
PubMed
Source
Phospho-peptide
Binding Domain
Smart/Pfam
ELM
PDB/MSD
Adapter molecule
Homo sapiens
Y139
YPRKVEEPSIYESVRVHTAMQ
Lck
10880360
LTP
-
-
-
-
             
 
Substrate
Short Description
UniPROT/Ensembl Id
Species
Interaction Network
Position
Sequence
Kinase
PubMed
Source
Phospho-peptide
Binding Domain
Smart/Pfam
ELM
PDB/MSD
Adapter molecule
Homo sapiens
Y273
CTRLEMPDNLYTFVLKVKDRT
Lck;
ZAP70
9169414
LTP
-
PH
-
-
             
 
Substrate
Short Description
UniPROT/Ensembl Id
Species
Interaction Network
Position
Sequence
Kinase
PubMed
Source
Phospho-peptide
Binding Domain
Smart/Pfam
ELM
PDB/MSD
Tyrosine kinase
Homo sapiens
Y512
GMTRFVLDDQYTSSTGTKFPV
Lck
9312162
15144186
12842872
17192257
HTP/LTP
-
TyrKc
-
-
             
 
Substrate
Short Description
UniPROT/Ensembl Id
Species
Interaction Network
Position
Sequence
Kinase
PubMed
Source
Phospho-peptide
Binding Domain
Smart/Pfam
ELM
PDB/MSD
protein kinase inhibitor activity
Homo sapiens
Y204
RKTVNGHLDSYEKVTQLPGPI
Lck
12783885
LTP
-
-
-
-
     
Y221
PGPIREFLDQYDAPL
Lck
12783885
15173187
LTP
-
-
-
-
             
 
Substrate
Short Description
UniPROT/Ensembl Id
Species
Interaction Network
Position
Sequence
Kinase
PubMed
Source
Phospho-peptide
Binding Domain
Smart/Pfam
ELM
PDB/MSD
Connection of cytoscheletro structure to plasma membrane
Homo sapiens
Y146
DYNKEVHKSGYLSSERLIPQR
Lck;
EGFR
1382070
12560083
LTP
-
B41
-
-
             
 
Substrate
Short Description
UniPROT/Ensembl Id
Species
Interaction Network
Position
Sequence
Kinase
PubMed
Source
Phospho-peptide
Binding Domain
Smart/Pfam
ELM
PDB/MSD
T-cell surface glycoprotein CD5 precursor (Lymphocyte glycoprotein T1/Leu-1) (Lymphocyte antigen CD5)
Homo sapiens
Y453
NPTASHVDNEYSQPPRNSRLS
Lck
12522270
15144186
11298344
15659558
HTP/LTP
-
-
-
-
     
Y487
MQPDNSSDSDYDLHGAQRL
Lck
11298344
LTP
-
-
-
-
             
 
Substrate
Short Description
UniPROT/Ensembl Id
Species
Interaction Network
Position
Sequence
Kinase
PubMed
Source
Phospho-peptide
Binding Domain
Smart/Pfam
ELM
PDB/MSD
T cell antigen receptor
Homo sapiens
Y307
FPAQDPCTTIYVAATEPVPES
Fyn;
Lck
11806999
LTP
-
-
-
-