List of substrates found:

Amyloid beta A4 protein  P130Cas  EGFR  Bcr  RIN1  p73  CAS-L  p62DOK 


Substrate: Amyloid beta A4 protein (Cell surface receptor)
Seq-ID: P05067 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
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Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 757 RHLSKMQQNGYENPTYKFFEQ - 11279131
LTP
1.00
ABL1 SH2;
GRB2 SH2;
SHC1 SH2
APP_amyloid
0.38
--
Y 757 RHLSKMQQNGYENPTYKFFEQ - 18083107
HTP
1.00
ABL1 SH2;
GRB2 SH2;
SHC1 SH2
APP_amyloid
0.38
--

Substrate: P130Cas (Adaptor molecule. Contain 15 YxxP motifs. )
Seq-ID: P56945 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 249 HLLAPGPQDIYDVPPVRGLLP FGFR1 12601080
LTP
1.00
ABL1 SH2;
CRKL SH2;
CRK SH2
-
0.56
- medium
Y 249 HLLAPGPQDIYDVPPVRGLLP - 18083107
HTP
1.00
ABL1 SH2;
CRKL SH2;
CRK SH2
-
0.56
- medium
Y 249 HLLAPGPQDIYDVPPVRGLLP - 16212419
HTP
1.00
ABL1 SH2;
CRKL SH2;
CRK SH2
-
0.56
- medium
Y 306 GLPPSNHHAVYDVPPSVSKDV FGFR1 12601080
LTP
0.94
ABL1 SH2;
CRKL SH2;
CRK SH2
-
0.73
- medium
Y 410 ADGGVVDSGVYAVPPPAEREA FGFR1 12601080
LTP
1.00
ABL1 SH2;
CRKL SH2;
CRK SH2
-
0.72
- medium

Substrate: EGFR (Receptor for EGF and other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor,)
Seq-ID: P00533 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1172 SHQISLDNPDYQQDFFPKEAK EGFR 8845374
LTP
1.00
ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 PTB;
SHC3 PTB;
Src SH2;
VAV2 SH2
-
0.67
--
Y 1172 SHQISLDNPDYQQDFFPKEAK - 15302935
HTP
1.00
ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 PTB;
SHC3 PTB;
Src SH2;
VAV2 SH2
-
0.67
--
Y 1172 SHQISLDNPDYQQDFFPKEAK - 17081983
HTP
1.00
ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 PTB;
SHC3 PTB;
Src SH2;
VAV2 SH2
-
0.67
--
Y 1172 SHQISLDNPDYQQDFFPKEAK - 18083107
HTP
1.00
ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 PTB;
SHC3 PTB;
Src SH2;
VAV2 SH2
-
0.67
--
Y 1197 FKGSTAENAEYLRVAPQSSEF EGFR 8845374
LTP
1.00
ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2
-
0.54
--
Y 1197 FKGSTAENAEYLRVAPQSSEF - 15302935
HTP
1.00
ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2
-
0.54
--
Y 1197 FKGSTAENAEYLRVAPQSSEF - 17081983
HTP
1.00
ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2
-
0.54
--
Y 1197 FKGSTAENAEYLRVAPQSSEF - 18083107
HTP
1.00
ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2
-
0.54
--

Substrate: Bcr (Breakpoint cluster region protein)
Seq-ID: P11274 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 177 QPGADAEKPFYVNVEFHHERG Fes 8955135
LTP
0.75
ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2
-
0.68
- medium
Y 177 QPGADAEKPFYVNVEFHHERG Fes 10405761
LTP
0.75
ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2
-
0.68
- medium
Y 177 QPGADAEKPFYVNVEFHHERG - 12522270
HTP
0.75
ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2
-
0.68
- medium
Y 177 QPGADAEKPFYVNVEFHHERG - 9178913
LTP
0.75
ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2
-
0.68
- medium
Y 177 QPGADAEKPFYVNVEFHHERG - 12124177
LTP
0.75
ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2
-
0.68
- medium
Y 177 QPGADAEKPFYVNVEFHHERG - 9407116
LTP
0.75
ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2
-
0.68
- medium
Y 177 QPGADAEKPFYVNVEFHHERG Abl 16912036
LTP
0.75
ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2
-
0.68
- medium
Y 177 QPGADAEKPFYVNVEFHHERG HCK 16912036
LTP
0.75
ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2
-
0.68
- medium
Y 177 QPGADAEKPFYVNVEFHHERG - 18083107
HTP
0.75
ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2
-
0.68
- medium
Y 246 SESSCGVDGDYEDAELNPRFL Fes 8955135
LTP
1.00
ABL1 SH2;
GRB10 SH2;
GRB2 SH2
-
0.57
- medium
Y 276 GSRPPWPPLEYQPYQSIYVGG Fes 8955135
LTP
0.00
ABL1 SH2;
GRB10 SH2;
GRB2 SH2;
SHC1 SH2;
SHC_group SH2
-
0.58
- medium
Y 279 PPWPPLEYQPYQSIYVGGMME Fes 8955135
LTP
1.00
ABL1 SH2;
GRB10 SH2;
GRB2 SH2;
SHC1 SH2;
SHC_group SH2
-
0.58
- medium
Y 283 PLEYQPYQSIYVGGMMEGEGK Fes 8955135
LTP
1.00
ABL1 SH2;
GRB10 SH2;
GRB2 SH2;
SHC1 SH2;
SHC_group SH2
-
0.61
- medium

Substrate: RIN1 (Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation)
Seq-ID: Q13671 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 36 AREKPAQDPLYDVPNASGGQA - 16497976
LTP
0.14
ABL1 SH2;
ABL2 SH2
-
0.77
- low
Y 36 AREKPAQDPLYDVPNASGGQA - 18083107
HTP
0.14
ABL1 SH2;
ABL2 SH2
-
0.77
- low

Substrate: p73 (Member of the TP53 family. It participates in the apoptotic response to DNA damage)
Seq-ID: O15350 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 99 HAASVPTHSPYAQPSSTFDTM Abl 10391251
LTP
1.00
ABL1 SH2 -
0.64
- medium

Substrate: CAS-L (Docking protein)
Seq-ID: Q14511 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 166 TPVRTGHGYVYEYPSRYQKDV - 12522270
HTP
1.00
ABL1 SH2;
CRKL SH2;
CRK SH2;
NCK SH2
-
0.43
- medium
Y 317 GQSVGSQNDAYDVPRGVQFLE - 18083107
HTP
1.00
ABL1 SH2;
CRKL SH2;
CRK SH2;
NCK SH2
-
0.70
- medium
Y 345 KANPQERDGVYDVPLHNPPDA - 18083107
HTP
1.00
ABL1 SH2;
CRKL SH2;
CRK SH2;
NCK SH2
-
0.86
- medium

Substrate: p62DOK (Docking protein, common target of PTKs)
Seq-ID: Q99704 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 296 QELLDSPPALYAEPLDSLRIA - 12087092
LTP
0.05
ABL1 SH2;
CRKL SH2;
RASA_group SH2
-
0.48
--
Y 296 QELLDSPPALYAEPLDSLRIA - 10688886
LTP
0.05
ABL1 SH2;
CRKL SH2;
RASA_group SH2
-
0.48
--
Y 315 IAPCPSQDSLYSDPLDSTSAQ - 12087092
LTP
1.00
ABL1 SH2;
CRKL SH2;
RASA_group SH2
-
0.66
--
Y 315 IAPCPSQDSLYSDPLDSTSAQ - 10688886
LTP
1.00
ABL1 SH2;
CRKL SH2;
RASA_group SH2
-
0.66
--
Y 315 IAPCPSQDSLYSDPLDSTSAQ - 18083107
HTP
1.00
ABL1 SH2;
CRKL SH2;
RASA_group SH2
-
0.66
--
Y 362 KLTDPKEDPIYDEPEGLAPVP - 12087092
LTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2
-
0.82
--
Y 362 KLTDPKEDPIYDEPEGLAPVP INSR 11551902
LTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2
-
0.82
--
Y 362 KLTDPKEDPIYDEPEGLAPVP - 10688886
LTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2
-
0.82
--
Y 362 KLTDPKEDPIYDEPEGLAPVP - 15592455
HTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2
-
0.82
--
Y 362 KLTDPKEDPIYDEPEGLAPVP - 16094384
HTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2
-
0.82
--
Y 377 GLAPVPPQGLYDLPREPKDAW - 12087092
LTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
RASA_group SH2
-
0.62
--
Y 377 GLAPVPPQGLYDLPREPKDAW - 10688886
LTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
RASA_group SH2
-
0.62
--
Y 377 GLAPVPPQGLYDLPREPKDAW - 15592455
HTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
RASA_group SH2
-
0.62
--
Y 377 GLAPVPPQGLYDLPREPKDAW - 16094384
HTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
RASA_group SH2
-
0.62
--
Y 398 WCQARVKEEGYELPYNPATDD - 12087092
LTP
0.17
ABL1 SH2;
CRKL SH2;
RASA_group SH2
-
0.48
--
Y 398 WCQARVKEEGYELPYNPATDD INSR 11551902
LTP
0.17
ABL1 SH2;
CRKL SH2;
RASA_group SH2
-
0.48
--
Y 398 WCQARVKEEGYELPYNPATDD - 10688886
LTP
0.17
ABL1 SH2;
CRKL SH2;
RASA_group SH2
-
0.48
--
Y 398 WCQARVKEEGYELPYNPATDD - 15592455
HTP
0.17
ABL1 SH2;
CRKL SH2;
RASA_group SH2
-
0.48
--
Y 398 WCQARVKEEGYELPYNPATDD - 16094384
HTP
0.17
ABL1 SH2;
CRKL SH2;
RASA_group SH2
-
0.48
--
Y 409 ELPYNPATDDYAVPPPRSTKP - 12087092
LTP
1.00
ABL1 SH2;
CRKL SH2;
RASA_group SH2
-
0.72
--
Y 409 ELPYNPATDDYAVPPPRSTKP - 10688886
LTP
1.00
ABL1 SH2;
CRKL SH2;
RASA_group SH2
-
0.72
--
Y 409 ELPYNPATDDYAVPPPRSTKP - 15592455
HTP
1.00
ABL1 SH2;
CRKL SH2;
RASA_group SH2
-
0.72
--
Y 409 ELPYNPATDDYAVPPPRSTKP - 16094384
HTP
1.00
ABL1 SH2;
CRKL SH2;
RASA_group SH2
-
0.72
--


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