a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

ErbB3  Ptpn11  FAK  Caveolin-1  c-kit  PDGF-R beta  ErbB2  EPHB1  TIE2 (TEK) 

Substrate:	ErbB3 (Receptor tyrosine kinase)
Seq-ID:	P21860 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-61514   CSK_HUMAN MINT-61518   GRB2_HUMAN MINT-61520   P85B_HUMAN MINT-74430   ABL1_HUMAN MINT-74454   ABL2_HUMAN MINT-74500   CRK_HUMAN MINT-74505   CRKL_HUMAN MINT-74509   DAB1_HUMAN MINT-74510   DAPP1_HUMAN MINT-74534   FER_HUMAN MINT-74539   FGFR1_HUMAN MINT-74548   GRB7_HUMAN MINT-74550   HCK_HUMAN MINT-74559   ITK_HUMAN MINT-74563   JAK2_HUMAN MINT-74564   JAK3_HUMAN MINT-74569   SH2B3_HUMAN MINT-74588   NCK1_HUMAN MINT-74592   NCK2_HUMAN MINT-74617   P85A_HUMAN MINT-74672   P55G_HUMAN MINT-74682   PLCG1_HUMAN MINT-74688   PTK6_HUMAN MINT-74708   RASA1_HUMAN MINT-74714   RIN1_HUMAN MINT-74738   SHC1_HUMAN MINT-74753   SRC_HUMAN MINT-74775   KSYK_HUMAN MINT-74784   TENC1_HUMAN MINT-74788   TENS3_HUMAN MINT-74795   TXK_HUMAN MINT-74803   VAV2_HUMAN MINT-74806   ZAP70_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process protein heterodimerization activity, transmembrane receptor protein tyrosine kinase activity, receptor signaling protein tyrosine kinase activity, protein homodimerization activity, protein tyrosine kinase activator activity, ATP binding, growth factor binding receptor complex, basolateral plasma membrane, integral to plasma membrane, extracellular space protein amino acid phosphorylation, positive regulation of phosphoinositide 3-kinase cascade, negative regulation of signal transduction, phosphoinositide 3-kinase cascade, heart development, negative regulation of secretion, neuron apoptosis, negative regulation of neuron apoptosis, regulation of cell proliferation, negative regulation of cell adhesion, transmembrane receptor protein tyrosine kinase signaling pathway, cranial nerve development, wound healing, Schwann cell differentiation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1199	EEEDEDEEYEYMNRRRRHSPP	-	9516479	LTP	1.00		GRB7 SH2; PIK3R1 SH2	-	0.92	-	medium
Y	1262	AGTTPDEDYEYMNRQRDGGGP	-	9516479	LTP	0.07		GRB7 SH2	-	0.88	-	medium

Substrate:	Ptpn11 (Protein-tyrosine phosphatase, non-receptor type 11)
Seq-ID:	Q06124 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-50695   CATA_HUMAN MINT-61523   ERBB4_HUMAN MINT-61552   GRB2_HUMAN MINT-74689   EGFR_HUMAN MINT-74691   ERBB2_HUMAN MINT-74885   DDR1_HUMAN MINT-6169406   GAB1_HUMAN MINT-6169440   PAXI_HUMAN MINT-6762811   IRS1_RAT MINT-6793881   CAV1_HUMAN MINT-6798640   MET_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process non-membrane spanning protein tyrosine phosphatase activity cytosol
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	584	AEMREDSARVYENVGLMQQQK	-	11684012	LTP	0.82		GRB7 SH2	-	0.51	-	-
Y	584	AEMREDSARVYENVGLMQQQK	-	8622870	LTP	0.82		GRB7 SH2	-	0.51	-	-
Y	584	AEMREDSARVYENVGLMQQQK	-	16094384	HTP	0.82		GRB7 SH2	-	0.51	-	-
Y	584	AEMREDSARVYENVGLMQQQK	-	18083107	HTP	0.82		GRB7 SH2	-	0.51	-	-
Y	584	AEMREDSARVYENVGLMQQQK	-	17287340	HTP	0.82		GRB7 SH2	-	0.51	-	-

Substrate:	FAK (Focal adhesion kinase)
Seq-ID:	Q05397 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-17602   LYN_HUMAN MINT-74938   BCAR1_HUMAN MINT-3381308   SRC_HUMAN MINT-6794892   PTN1_HUMAN MINT-7294020   P53_HUMAN MINT-7385708   SRC_MOUSE
GO-Terms:	[show] Molecular Function Cellular Component Biological Process non-membrane spanning protein tyrosine kinase activity, ATP binding, SH2 domain binding, signal transducer activity focal adhesion, cytosol, cytoskeleton signal complex assembly, integrin-mediated signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	397	HAVSVSETDDYAEIIDEEDTY	FAK	7509446	LTP	1.00		Fyn SH2; GRB2 SH2; GRB7 SH2; NCK SH2; PIK3R1 SH2; Src SH2; STAT3 SH2	-	0.49	-	-
Y	397	HAVSVSETDDYAEIIDEEDTY	-	17192257	HTP	1.00		Fyn SH2; GRB2 SH2; GRB7 SH2; NCK SH2; PIK3R1 SH2; Src SH2; STAT3 SH2	-	0.49	-	-
Y	397	HAVSVSETDDYAEIIDEEDTY	-	18083107	HTP	1.00		Fyn SH2; GRB2 SH2; GRB7 SH2; NCK SH2; PIK3R1 SH2; Src SH2; STAT3 SH2	-	0.49	-	-

Substrate:	Caveolin-1 (May act as a scaffolding protein within the caveolar membranes )
Seq-ID:	P49817 [Mus musculus]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-7307575   TRXR1_HUMAN MINT-7307618   TRXR1_MOUSE
GO-Terms:	[show] Molecular Function Cellular Component Biological Process peptidase activator activity caveola, integral to membrane of membrane fraction, integral to plasma membrane, perinuclear region of cytoplasm, protein complex, cell cortex, endoplasmic reticulum, Golgi membrane negative regulation of gene-specific transcription from RNA polymerase II promoter, positive regulation of vasoconstriction, inactivation of MAPK activity, negative regulation of tyrosine phosphorylation of Stat5 protein, cholesterol homeostasis, positive regulation of calcium ion transport into cytosol, lipid storage, mammary gland involution, vasoconstriction, negative regulation of nitric oxide biosynthetic process, negative regulation of canonical Wnt receptor signaling pathway, negative regulation of epithelial cell differentiation, positive regulation of metalloenzyme activity, response to calcium ion, negative regulation of MAPKKK cascade, lactation, vasculogenesis, calcium ion transport, skeletal muscle tissue development, T cell costimulation, triglyceride metabolic process, protein homooligomerization, negative regulation of endothelial cell proliferation, nitric oxide homeostasis, endocytosis, negative regulation of cytokine-mediated signaling pathway, regulation of smooth muscle contraction, membrane depolarization, regulation of fatty acid metabolic process, response to hypoxia, response to estrogen stimulus
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	14	GKYVDSEGHLYTVPIREQGNI	-	12036959	LTP	-		GRB7 SH2	Caveolin	0.30	-	low
Y	14	GKYVDSEGHLYTVPIREQGNI	Abl	11075810	LTP	-		GRB7 SH2	Caveolin	0.30	-	low
Y	14	GKYVDSEGHLYTVPIREQGNI	SRC	11075810	LTP	-		GRB7 SH2	Caveolin	0.30	-	low
Y	14	GKYVDSEGHLYTVPIREQGNI	SRC	8632005	LTP	-		GRB7 SH2	Caveolin	0.30	-	low
Y	14	GKYVDSEGHLYTVPIREQGNI	Abl	12531427	LTP	-		GRB7 SH2	Caveolin	0.30	-	low
Y	14	GKYVDSEGHLYTVPIREQGNI	-	11094059	LTP	-		GRB7 SH2	Caveolin	0.30	-	low
Y	14	GKYVDSEGHLYTVPIREQGNI	-	15592455	HTP	-		GRB7 SH2	Caveolin	0.30	-	low

Substrate:	c-kit (Receptor tyrosine kinase)
Seq-ID:	P10721 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process receptor signaling protein tyrosine kinase activity, ATP binding, protein binding integral to membrane, extracellular space male gonad development, transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	936	KQISESTNHIYSNLANCSPNR	Kit	10377264	LTP	1.00		GRB2 SH2; GRB7 SH2; PLCG1 SH2	-	0.38	-	-
Y	936	KQISESTNHIYSNLANCSPNR	-	18083107	HTP	1.00		GRB2 SH2; GRB7 SH2; PLCG1 SH2	-	0.38	-	-

Substrate:	PDGF-R beta (Beta platelet-derived growth factor receptor)
Seq-ID:	P09619 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-2832596   NHRF2_HUMAN MINT-2832984   PTEN_HUMAN MINT-2833042   NHRF1_HUMAN MINT-6762380   PTN1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process vascular endothelial growth factor receptor activity, platelet-derived growth factor binding, platelet activating factor receptor activity, platelet-derived growth factor receptor binding, ATP binding, platelet-derived growth factor beta-receptor activity integral to plasma membrane positive regulation of cell proliferation, positive regulation of cell migration, protein amino acid autophosphorylation, peptidyl-tyrosine phosphorylation, cell chemotaxis
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	716	DKRRPPSAELYSNALPVGLPL	PDGFR_beta	8940081	LTP	1.00		GRB2 SH2; GRB7 SH2	TyrKc	0.46	-	medium
Y	716	DKRRPPSAELYSNALPVGLPL	PDGFR_beta	7935391	LTP	1.00		GRB2 SH2; GRB7 SH2	TyrKc	0.46	-	medium
Y	775	DIESSNYMAPYDNYVPSAPER	PDGFR_beta	8940081	LTP	1.00		GRB2 SH2; GRB7 SH2; STAT5 SH2	TyrKc	0.34	-	medium

Substrate:	ErbB2 (Receptor tyrosine kinase)
Seq-ID:	P04626 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-61505   P85B_HUMAN MINT-74429   ABL1_HUMAN MINT-74444   ABL2_HUMAN MINT-74462   ANS1A_HUMAN MINT-74470   APBB1_HUMAN MINT-74486   BLNK_HUMAN MINT-74488   BMX_HUMAN MINT-74498   CRK_HUMAN MINT-74502   CRKL_HUMAN MINT-74508   DAB1_HUMAN MINT-74512   DOK1_HUMAN MINT-74521   SPT6H_HUMAN MINT-74533   FER_HUMAN MINT-74538   FGR_HUMAN MINT-74540   GRAP2_HUMAN MINT-74542   GRB2_HUMAN MINT-74544   GRB7_HUMAN MINT-74553   IRS1_HUMAN MINT-74556   IRS4_HUMAN MINT-74558   ITK_HUMAN MINT-74561   JAK1_HUMAN MINT-74567   SH2B3_HUMAN MINT-74575   JIP1_HUMAN MINT-74582   MATK_HUMAN MINT-74590   NCK2_HUMAN MINT-74610   P85A_HUMAN MINT-74664   P55G_HUMAN MINT-74680   PLCG1_HUMAN MINT-74686   PLCG2_HUMAN MINT-74691   PTN11_HUMAN MINT-74712   RASA1_HUMAN MINT-74713   RIN1_HUMAN MINT-74722   SH22A_HUMAN MINT-74723   SH23A_HUMAN MINT-74724   3BP2_HUMAN MINT-74737   SHC1_HUMAN MINT-74747   SLAP1_HUMAN MINT-74755   STAT1_HUMAN MINT-74756   STAT3_HUMAN MINT-74769   KSYK_HUMAN MINT-74777   TEC_HUMAN MINT-74781   TENC1_HUMAN MINT-74786   TENS3_HUMAN MINT-74793   TLN1_HUMAN MINT-74794   TXK_HUMAN MINT-74802   VAV2_HUMAN MINT-1788719   EGFR_HUMAN MINT-1901925   LAP2_MOUSE
GO-Terms:	[show] Molecular Function Cellular Component Biological Process epidermal growth factor receptor activity, ErbB-3 class receptor binding, protein heterodimerization activity, DNA binding, protein C-terminus binding, identical protein binding, receptor signaling protein tyrosine kinase activity, ATP binding, protein phosphatase binding receptor complex, integral to membrane, nucleus, perinuclear region of cytoplasm regulation of angiogenesis, transcription, regulation of transcription, phosphoinositide 3-kinase cascade, phosphoinositide-mediated signaling, heart development, positive regulation of cell adhesion, protein amino acid autophosphorylation, positive regulation of epithelial cell proliferation, wound healing, positive regulation of MAP kinase activity, cell proliferation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1139	APLTCSPQPEYVNQPDVRPQP	ErbB2	11500516	LTP	1.00		GRB2 SH2; GRB7 SH2; Src SH2; STAT3 SH2	-	0.85	-	low

Substrate:	EPHB1 (Receptor for member of the ephrinB family)
Seq-ID:	Q07494 [Gallus gallus]
Download:	fasta csv
Interaction Network(s):	-
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process ephrin receptor activity, ATP binding, protein binding integral to plasma membrane protein amino acid phosphorylation, transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	928	DWLSAVKMSQYRDNFLSAGFT	-	12223469	LTP	1.00		GRB10 SH2; GRB7 SH2	SAM	0.15	-	low
Y	928	DWLSAVKMSQYRDNFLSAGFT	-	7731717	LTP	1.00		GRB10 SH2; GRB7 SH2	SAM	0.15	-	low

Substrate:	TIE2 (TEK) (PTK receptor for angiopoietin 1)
Seq-ID:	Q02763 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process transmembrane receptor protein tyrosine kinase activity, ATP binding, protein binding basolateral plasma membrane, integral to plasma membrane, cell surface, microvillus, apical plasma membrane, membrane raft positive regulation of ERK1 and ERK2 cascade, protein amino acid phosphorylation, protein oligomerization, cell-cell signaling, positive regulation of protein kinase B signaling cascade, regulation of cell proliferation, transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1102	LNRMLEERKTYVNTTLYEKFT	-	10521483	LTP	1.00		GRB2 SH2; GRB7 SH2; PIK3R1 SH2; PIK3R2 SH2; SHC1 SH2	-	0.15	1FVR	3.49%
Y	1102	LNRMLEERKTYVNTTLYEKFT	-	9632797	LTP	1.00		GRB2 SH2; GRB7 SH2; PIK3R1 SH2; PIK3R2 SH2; SHC1 SH2	-	0.15	1FVR	3.49%
Y	1102	LNRMLEERKTYVNTTLYEKFT	TIE2	12082108	LTP	1.00		GRB2 SH2; GRB7 SH2; PIK3R1 SH2; PIK3R2 SH2; SHC1 SH2	-	0.15	1FVR	3.49%