List of substrates found:

ErbB3  Ptpn11  FAK  Caveolin-1  c-kit  PDGF-R beta  ErbB2  EPHB1  TIE2 (TEK) 


Substrate: ErbB3 (Receptor tyrosine kinase)
Seq-ID: P21860 [Homo sapiens]
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1199 EEEDEDEEYEYMNRRRRHSPP - 9516479
LTP
1.00
GRB7 SH2;
PIK3R1 SH2
-
0.92
- medium
Y 1262 AGTTPDEDYEYMNRQRDGGGP - 9516479
LTP
0.07
GRB7 SH2 -
0.88
- medium

Substrate: Ptpn11 (Protein-tyrosine phosphatase, non-receptor type 11)
Seq-ID: Q06124 [Homo sapiens]
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
non-membrane spanning protein tyrosine phosphatase activity cytosol
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 584 AEMREDSARVYENVGLMQQQK - 11684012
LTP
0.82
GRB7 SH2 -
0.51
--
Y 584 AEMREDSARVYENVGLMQQQK - 8622870
LTP
0.82
GRB7 SH2 -
0.51
--
Y 584 AEMREDSARVYENVGLMQQQK - 16094384
HTP
0.82
GRB7 SH2 -
0.51
--
Y 584 AEMREDSARVYENVGLMQQQK - 18083107
HTP
0.82
GRB7 SH2 -
0.51
--
Y 584 AEMREDSARVYENVGLMQQQK - 17287340
HTP
0.82
GRB7 SH2 -
0.51
--

Substrate: FAK (Focal adhesion kinase)
Seq-ID: Q05397 [Homo sapiens]
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 397 HAVSVSETDDYAEIIDEEDTY FAK 7509446
LTP
1.00
Fyn SH2;
GRB2 SH2;
GRB7 SH2;
NCK SH2;
PIK3R1 SH2;
Src SH2;
STAT3 SH2
-
0.49
--
Y 397 HAVSVSETDDYAEIIDEEDTY - 17192257
HTP
1.00
Fyn SH2;
GRB2 SH2;
GRB7 SH2;
NCK SH2;
PIK3R1 SH2;
Src SH2;
STAT3 SH2
-
0.49
--
Y 397 HAVSVSETDDYAEIIDEEDTY - 18083107
HTP
1.00
Fyn SH2;
GRB2 SH2;
GRB7 SH2;
NCK SH2;
PIK3R1 SH2;
Src SH2;
STAT3 SH2
-
0.49
--

Substrate: Caveolin-1 (May act as a scaffolding protein within the caveolar membranes )
Seq-ID: P49817 [Mus musculus]
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 14 GKYVDSEGHLYTVPIREQGNI - 12036959
LTP
- GRB7 SH2 Caveolin
0.30
- low
Y 14 GKYVDSEGHLYTVPIREQGNI Abl 11075810
LTP
- GRB7 SH2 Caveolin
0.30
- low
Y 14 GKYVDSEGHLYTVPIREQGNI SRC 11075810
LTP
- GRB7 SH2 Caveolin
0.30
- low
Y 14 GKYVDSEGHLYTVPIREQGNI SRC 8632005
LTP
- GRB7 SH2 Caveolin
0.30
- low
Y 14 GKYVDSEGHLYTVPIREQGNI Abl 12531427
LTP
- GRB7 SH2 Caveolin
0.30
- low
Y 14 GKYVDSEGHLYTVPIREQGNI - 11094059
LTP
- GRB7 SH2 Caveolin
0.30
- low
Y 14 GKYVDSEGHLYTVPIREQGNI - 15592455
HTP
- GRB7 SH2 Caveolin
0.30
- low

Substrate: c-kit (Receptor tyrosine kinase)
Seq-ID: P10721 [Homo sapiens]
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 936 KQISESTNHIYSNLANCSPNR Kit 10377264
LTP
1.00
GRB2 SH2;
GRB7 SH2;
PLCG1 SH2
-
0.38
--
Y 936 KQISESTNHIYSNLANCSPNR - 18083107
HTP
1.00
GRB2 SH2;
GRB7 SH2;
PLCG1 SH2
-
0.38
--

Substrate: PDGF-R beta (Beta platelet-derived growth factor receptor)
Seq-ID: P09619 [Homo sapiens]
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 716 DKRRPPSAELYSNALPVGLPL PDGFR_beta 8940081
LTP
1.00
GRB2 SH2;
GRB7 SH2
TyrKc
0.46
- medium
Y 716 DKRRPPSAELYSNALPVGLPL PDGFR_beta 7935391
LTP
1.00
GRB2 SH2;
GRB7 SH2
TyrKc
0.46
- medium
Y 775 DIESSNYMAPYDNYVPSAPER PDGFR_beta 8940081
LTP
1.00
GRB2 SH2;
GRB7 SH2;
STAT5 SH2
TyrKc
0.34
- medium

Substrate: ErbB2 (Receptor tyrosine kinase)
Seq-ID: P04626 [Homo sapiens]
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1139 APLTCSPQPEYVNQPDVRPQP ErbB2 11500516
LTP
1.00
GRB2 SH2;
GRB7 SH2;
Src SH2;
STAT3 SH2
-
0.85
- low

Substrate: EPHB1 (Receptor for member of the ephrinB family)
Seq-ID: Q07494 [Gallus gallus]
Interaction Network(s): -
External Source(s):
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 928 DWLSAVKMSQYRDNFLSAGFT - 12223469
LTP
1.00
GRB10 SH2;
GRB7 SH2
SAM
0.15
- low
Y 928 DWLSAVKMSQYRDNFLSAGFT - 7731717
LTP
1.00
GRB10 SH2;
GRB7 SH2
SAM
0.15
- low

Substrate: TIE2 (TEK) (PTK receptor for angiopoietin 1)
Seq-ID: Q02763 [Homo sapiens]
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1102 LNRMLEERKTYVNTTLYEKFT - 10521483
LTP
1.00
GRB2 SH2;
GRB7 SH2;
PIK3R1 SH2;
PIK3R2 SH2;
SHC1 SH2
-
0.15
1FVR 3.49%
Y 1102 LNRMLEERKTYVNTTLYEKFT - 9632797
LTP
1.00
GRB2 SH2;
GRB7 SH2;
PIK3R1 SH2;
PIK3R2 SH2;
SHC1 SH2
-
0.15
1FVR 3.49%
Y 1102 LNRMLEERKTYVNTTLYEKFT TIE2 12082108
LTP
1.00
GRB2 SH2;
GRB7 SH2;
PIK3R1 SH2;
PIK3R2 SH2;
SHC1 SH2
-
0.15
1FVR 3.49%


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