List of substrates found:

Band 3 anion transport protein  Bcr  Insulin receptor substrate 1  Integrin beta 3  CTLA-4  Common beta c subunit  LAIR1  STAT 5  PDGF-R alpha  CD31  G-CSF-R  Gab1  Gab2  FCGR2B  c-kit  Leptin receptor  CD33  p62DOK  EGFR  Epo-R  IGF1-R  IL-4R alpha  IL-6R (gp130)  Protein zero related protein  PYK2  PDGF-R beta  TIE2 (TEK)  VEGFR-1  AT1AR  Insulin R  CD150 


Substrate: Band 3 anion transport protein (Anion exchange protein 1)
Seq-ID: P02730 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-58445   CD2A1_HUMAN
MINT-6793324   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
inorganic anion exchanger activity,
protein homodimerization activity,
protein anchor,
ankyrin binding		 cortical cytoskeleton,
basolateral plasma membrane,
integral to plasma membrane		 cellular ion homeostasis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 359 SSPAKPDSSFYKGLDLNGGPD Lyn 10942405
LTP
0.11
 PTPN11 SH2 -
0.45
 --
Y 359 SSPAKPDSSFYKGLDLNGGPD SYK 10942405
LTP
0.11
 PTPN11 SH2 -
0.45
 --
Y 359 SSPAKPDSSFYKGLDLNGGPD - 18083107
HTP
0.11
 PTPN11 SH2 -
0.45
 --

Substrate: Bcr (Breakpoint cluster region protein)
Seq-ID: P11274 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-69534   AT2B1_HUMAN
MINT-69536   CLH1_HUMAN
MINT-69537   CFTR_HUMAN
MINT-69540   ZO2_HUMAN
MINT-69542   RGS12_HUMAN
MINT-4961172   AFAD_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
Rho guanyl-nucleotide exchange factor activity,
protein serine/threonine kinase activity,
ATP binding,
GTPase activator activity		 intracellular protein amino acid phosphorylation,
signal transduction,
regulation of Rho protein signal transduction
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 177 QPGADAEKPFYVNVEFHHERG Fes 8955135
LTP
0.75
 ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2		 -
0.68
 - medium
Y 177 QPGADAEKPFYVNVEFHHERG Fes 10405761
LTP
0.75
 ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2		 -
0.68
 - medium
Y 177 QPGADAEKPFYVNVEFHHERG - 12522270
HTP
0.75
 ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2		 -
0.68
 - medium
Y 177 QPGADAEKPFYVNVEFHHERG - 9178913
LTP
0.75
 ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2		 -
0.68
 - medium
Y 177 QPGADAEKPFYVNVEFHHERG - 12124177
LTP
0.75
 ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2		 -
0.68
 - medium
Y 177 QPGADAEKPFYVNVEFHHERG - 9407116
LTP
0.75
 ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2		 -
0.68
 - medium
Y 177 QPGADAEKPFYVNVEFHHERG Abl 16912036
LTP
0.75
 ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2		 -
0.68
 - medium
Y 177 QPGADAEKPFYVNVEFHHERG HCK 16912036
LTP
0.75
 ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2		 -
0.68
 - medium
Y 177 QPGADAEKPFYVNVEFHHERG - 18083107
HTP
0.75
 ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2		 -
0.68
 - medium

Substrate: Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID: P35568 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19010   INSR_HUMAN
MINT-68735   P85A_HUMAN
MINT-74551   EGFR_HUMAN
MINT-74553   ERBB2_HUMAN
MINT-3975430   1433S_HUMAN
MINT-6628637   LT_SV40
MINT-6793745   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoinositide 3-kinase binding,
protein kinase C binding,
insulin-like growth factor receptor binding,
insulin receptor binding,
transmembrane receptor protein tyrosine kinase docking protein activity,
SH2 domain binding		 microsome,
caveola,
cytosol,
insulin receptor complex,
nucleus		 negative regulation of insulin receptor signaling pathway,
glucose homeostasis,
positive regulation of insulin receptor signaling pathway,
positive regulation of fatty acid beta-oxidation,
phosphoinositide 3-kinase cascade,
negative regulation of insulin secretion,
positive regulation of glycogen biosynthetic process,
insulin receptor signaling pathway,
positive regulation of glucose import,
positive regulation of phosphoinositide 3-kinase activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 662 RHPQRVDPNGYMMMSPSGGCS - 15592455
HTP
1.00
 Fyn SH2;
MATK SH2;
PIK3R1 SH2;
PTPN11 SH2		 -
0.77
 --
Y 896 HPPEPKSPGEYVNIEFGSDQS - 11259577
LTP
1.00
 GRB2 SH2;
PTPN11 SH2		 -
0.76
 --

Substrate: Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID: P35570 [Rattus norvegicus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-45938   ITB2_HUMAN
MINT-45939   ITB3_HUMAN
MINT-60761   INSR_RAT
MINT-6762786   GRB2_HUMAN
MINT-6762811   PTN11_HUMAN
MINT-6762830   PTPRA_HUMAN
MINT-6762866   PTN1_HUMAN
MINT-6762880   P85A_HUMAN
MINT-6762904   CRK_HUMAN
MINT-6795115   INSR_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoinositide 3-kinase binding,
protein kinase C binding,
insulin-like growth factor receptor binding,
insulin-like growth factor receptor activity,
insulin receptor binding,
transmembrane receptor protein tyrosine kinase docking protein activity,
SH2 domain binding		 microsome,
cytosol,
insulin receptor complex,
nucleus		 negative regulation of insulin receptor signaling pathway,
negative regulation of somatostatin secretion,
positive regulation of insulin receptor signaling pathway,
negative regulation of insulin secretion,
protein heterooligomerization,
insulin receptor signaling pathway,
positive regulation of phosphoinositide 3-kinase activity,
positive regulation of phosphorylation,
positive regulation of glucagon secretion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1172 AAGGLEKSLNYIDLDLVKDVK INSR 7504175
LTP
1.00
 PTPN11 SH2 -
0.48
 - medium
Y 1172 AAGGLEKSLNYIDLDLVKDVK IGF1R 11572799
LTP
1.00
 PTPN11 SH2 -
0.48
 - medium
Y 1172 AAGGLEKSLNYIDLDLVKDVK INSR 11572799
LTP
1.00
 PTPN11 SH2 -
0.48
 - medium
Y 1222 PRRSSEDLSTYASINFQKQPE INSR 7504175
LTP
0.09
 PTPN11 SH2 -
0.77
 - medium
Y 1222 PRRSSEDLSTYASINFQKQPE - 12220227
LTP
0.09
 PTPN11 SH2 -
0.77
 - medium

Substrate: Integrin beta 3 (Platelet membrane glycoprotein IIIa)
Seq-ID: P05106 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-25081   ITAV_HUMAN
MINT-45900   EPS8_HUMAN
MINT-45905   RBGP1_HUMAN
MINT-45913   GULP1_HUMAN
MINT-45916   RGS12_HUMAN
MINT-45923   DAB1_MOUSE
MINT-45928   DAB2_MOUSE
MINT-45939   IRS1_RAT
MINT-45952   TLN1_MOUSE
MINT-45957   JIP1_HUMAN
MINT-45960   LIN10_CAEEL
MINT-61480   TENC1_HUMAN
MINT-61568   DOK1_MOUSE
MINT-61569   NUMB_MOUSE
MINT-1795026   TLN1_HUMAN
MINT-6794817   PTN1_HUMAN
MINT-7384376   SRC_MOUSE
MINT-7384444   LYN_HUMAN
MINT-7384460   YES_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor activity,
vascular endothelial growth factor receptor 2 binding,
identical protein binding,
platelet-derived growth factor receptor binding,
cell adhesion molecule binding		 integrin complex,
alphav-beta3 integrin-vitronectin complex,
platelet alpha granule membrane		 positive regulation of peptidyl-tyrosine phosphorylation,
positive regulation of endothelial cell proliferation,
regulation of bone resorption,
blood coagulation,
negative regulation of lipid transport,
tube development,
activation of protein kinase activity,
integrin-mediated signaling pathway,
positive regulation of vascular endothelial growth factor receptor signaling pathway,
negative regulation of lipid storage,
negative regulation of macrophage derived foam cell differentiation,
cell-matrix adhesion,
interspecies interaction between organisms,
smooth muscle cell migration,
negative regulation of lipoprotein metabolic process,
angiogenesis involved in wound healing,
positive regulation of endothelial cell migration,
negative regulation of low-density lipoprotein receptor biosynthetic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 773 AKWDTANNPLYKEATSTFTNI - 8631894
LTP
1.00
 GRB2 SH2;
PTPN11 SH2;
SHC1 PTB;
TLN1 PTB		 Integrin_b_cyt
0.26
 --
Y 773 AKWDTANNPLYKEATSTFTNI SRC 15699036
LTP
1.00
 GRB2 SH2;
PTPN11 SH2;
SHC1 PTB;
TLN1 PTB		 Integrin_b_cyt
0.26
 --
Y 773 AKWDTANNPLYKEATSTFTNI - 18088087
HTP
1.00
 GRB2 SH2;
PTPN11 SH2;
SHC1 PTB;
TLN1 PTB		 Integrin_b_cyt
0.26
 --
Y 773 AKWDTANNPLYKEATSTFTNI SRC 18398066
LTP
1.00
 GRB2 SH2;
PTPN11 SH2;
SHC1 PTB;
TLN1 PTB		 Integrin_b_cyt
0.26
 --
Y 785 EATSTFTNITYRGT        SYK 8631894
LTP
0.98
 PTPN11 SH2;
SHC1 PTB;
SYK SH2		 Integrin_b_cyt
0.26
 --
Y 785 EATSTFTNITYRGT        SRC 8631894
LTP
0.98
 PTPN11 SH2;
SHC1 PTB;
SYK SH2		 Integrin_b_cyt
0.26
 --
Y 785 EATSTFTNITYRGT        - 18088087
HTP
0.98
 PTPN11 SH2;
SHC1 PTB;
SYK SH2		 Integrin_b_cyt
0.26
 --

Substrate: CTLA-4 (CD152 antigen)
Seq-ID: P16410 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
external side of plasma membrane,
integral to plasma membrane,
Golgi apparatus,
perinuclear region of cytoplasm,
clathrin-coated endocytic vesicle		 negative regulation of regulatory T cell differentiation,
immune response
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 201 KKRSPLTTGVYVKMPPTEPEC JAK2 10842319
LTP
1.00
 PIK3R1 SH2;
PTPN11 SH2		 -
0.37
 - low
Y 201 KKRSPLTTGVYVKMPPTEPEC TXK 9813138
LTP
1.00
 PIK3R1 SH2;
PTPN11 SH2		 -
0.37
 - low

Substrate: Common beta c subunit (Cytokine recpetor common beta chain)
Seq-ID: P32927 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cytokine receptor activity granulocyte macrophage colony-stimulating factor receptor complex respiratory gaseous exchange
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 593 QASSFDFNGPYLGPPHSRSLP - 9257712
LTP
1.00
 PTPN11 SH2;
SHC1 PTB;
SHC_group SH2		 -
0.76
 - medium
Y 593 QASSFDFNGPYLGPPHSRSLP - 10362354
LTP
1.00
 PTPN11 SH2;
SHC1 PTB;
SHC_group SH2		 -
0.76
 - medium
Y 628 QKSPPPGSLEYLCLPAGGQVQ - 9257712
LTP
1.00
 PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2;
STAT5 SH2		 -
0.71
 - medium
Y 628 QKSPPPGSLEYLCLPAGGQVQ - 10362354
LTP
1.00
 PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2;
STAT5 SH2		 -
0.71
 - medium
Y 766 PGPVKSGFEGYVELPPIEGRS - 9257712
LTP
1.00
 PTPN11 SH2;
SHC1 SH2;
SHC_group SH2;
STAT5 SH2		 -
0.69
 - medium

Substrate: LAIR1 (Cell surface receptor)
Seq-ID: Q6GTX8 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor activity,
protein binding		 plasma membrane,
integral to membrane
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 251 LAAGSSQEVTYAQLDHWALTQ - 10764762
LTP
0.28
 PTPN11 SH2;
PTPN6 SH2		 -
0.33
 - low

Substrate: STAT 5 (Transcription factor)
Seq-ID: P42229 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-50646   ESR1_HUMAN
MINT-58264   STAP2_HUMAN
MINT-6793989   PTN1_HUMAN
MINT-7891339   EPOR_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
calcium ion binding,
sequence-specific DNA binding transcription factor activity,
protein binding		 cytoplasm,
nucleus		 valine metabolic process,
oxaloacetate metabolic process,
transcription,
creatinine metabolic process,
isoleucine metabolic process,
JAK-STAT cascade,
taurine metabolic process,
allantoin metabolic process,
fatty acid metabolic process,
citrate metabolic process,
2-oxoglutarate metabolic process,
succinate metabolic process,
creatine metabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 694 TPVLAKAVDGYVKPQIKQVVP Lyn 11641791
LTP
0.25
 CRKL SH2;
PTPN11 SH2;
STAT5 SH2		 SH2
0.20
 - medium
Y 694 TPVLAKAVDGYVKPQIKQVVP SRC 11641791
LTP
0.25
 CRKL SH2;
PTPN11 SH2;
STAT5 SH2		 SH2
0.20
 - medium
Y 694 TPVLAKAVDGYVKPQIKQVVP JAK2 11641791
LTP
0.25
 CRKL SH2;
PTPN11 SH2;
STAT5 SH2		 SH2
0.20
 - medium
Y 694 TPVLAKAVDGYVKPQIKQVVP - 17081983
HTP
0.25
 CRKL SH2;
PTPN11 SH2;
STAT5 SH2		 SH2
0.20
 - medium
Y 694 TPVLAKAVDGYVKPQIKQVVP - 18083107
HTP
0.25
 CRKL SH2;
PTPN11 SH2;
STAT5 SH2		 SH2
0.20
 - medium

Substrate: PDGF-R alpha (Receptor tyrosine kinase)
Seq-ID: P16234 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
platelet-derived growth factor alpha-receptor activity,
vascular endothelial growth factor receptor activity,
platelet-derived growth factor binding,
protein homodimerization activity,
platelet-derived growth factor receptor binding,
ATP binding		 integral to plasma membrane positive regulation of DNA replication,
positive regulation of fibroblast proliferation,
cell activation,
positive regulation of cell migration,
protein amino acid autophosphorylation,
peptidyl-tyrosine phosphorylation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 720 LNPADESTRSYVILSFENNGD - 11818394
LTP
0.21
 PTPN11 SH2;
SHB SH2		 TyrKc
0.29
 - medium
Y 754 PMLERKEVSKYSDIQRSLYDR PDGFR_alpha 7523122
LTP
0.27
 PTPN11 SH2 TyrKc
0.29
 - medium

Substrate: CD31 (Adhesion molecule)
Seq-ID: P16284 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-61866   PR40A_HUMAN
MINT-63486   KU70_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein binding cell junction,
integral to membrane,
extracellular space,
platelet alpha granule membrane		 signal transduction,
diapedesis,
cell recognition,
cell adhesion,
phagocytosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 690 NKEPLNSDVQYTEVQVSSAES - 15201144
LTP
1.00
 INPP5D SH2;
PLCG1 SH2;
PTPN11 SH2;
PTPN6 SH2;
Src SH2		 -
0.58
 - medium
Y 713 DLGKKDTETVYSEVRKAVPDA - 15592455
HTP
1.00
 PLCG1 SH2;
PTPN11 SH2;
PTPN6 SH2;
Src SH2		 -
0.63
 - medium
Y 713 DLGKKDTETVYSEVRKAVPDA - 18088087
HTP
1.00
 PLCG1 SH2;
PTPN11 SH2;
PTPN6 SH2;
Src SH2		 -
0.63
 - medium
Y 713 DLGKKDTETVYSEVRKAVPDA - 18083107
HTP
1.00
 PLCG1 SH2;
PTPN11 SH2;
PTPN6 SH2;
Src SH2		 -
0.63
 - medium

Substrate: G-CSF-R (Granulocyte colony stimulating factor receptor)
Seq-ID: P40223 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cytokine receptor activity integral to membrane neutrophil chemotaxis,
cell adhesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 728 NGSLPALVQAYVLQGDPREIS - 8608222
LTP
1.00
 PTPN11 SH2;
STAT3 SH2		 -
0.41
 - medium
Y 728 NGSLPALVQAYVLQGDPREIS - 10329697
LTP
1.00
 PTPN11 SH2;
STAT3 SH2		 -
0.41
 - medium
Y 788 LGGPTPSPKSYENIWFHSRPQ - 8608222
LTP
1.00
 GRB2 SH2;
PTPN11 SH2;
SHC_group SH2		 -
0.60
 - medium

Substrate: Gab1 (Multisubstrate docking protein downstream in the signaling pathways of different RTK.)
Seq-ID: Q13480 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-58395   GRB2_HUMAN
MINT-58403   GRAP2_HUMAN
MINT-58404   MET_HUMAN
MINT-68564   BMX_HUMAN
MINT-1893011   P85A_HUMAN
MINT-6169406   PTN11_HUMAN
MINT-6169502   PAXI_HUMAN
MINT-7971128   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3/SH2 adaptor activity cytosol epidermal growth factor receptor signaling pathway,
insulin receptor signaling pathway,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 447 SVSSEELDENYVPMNPNSPPR INSR 10978177
LTP
1.00
 PIK3R1 SH2;
PIK3R2 SH2;
PTPN11 SH2		 -
0.83
 - low
Y 447 SVSSEELDENYVPMNPNSPPR EGFR 9890893
LTP
1.00
 PIK3R1 SH2;
PIK3R2 SH2;
PTPN11 SH2		 -
0.83
 - low
Y 447 SVSSEELDENYVPMNPNSPPR Met 10734310
LTP
1.00
 PIK3R1 SH2;
PIK3R2 SH2;
PTPN11 SH2		 -
0.83
 - low
Y 589 SSDSHDSEENYVPMNPNLSSE INSR 10978177
LTP
1.00
 PIK3R1 SH2;
PTPN11 SH2		 -
0.89
 - low
Y 589 SSDSHDSEENYVPMNPNLSSE EGFR 9890893
LTP
1.00
 PIK3R1 SH2;
PTPN11 SH2		 -
0.89
 - low
Y 589 SSDSHDSEENYVPMNPNLSSE Met 10734310
LTP
1.00
 PIK3R1 SH2;
PTPN11 SH2		 -
0.89
 - low
Y 627 IKPKGDKQVEYLDLDLDSGKS INSR 10978177
LTP
1.00
 PTPN11 SH2 -
0.72
 - low
Y 627 IKPKGDKQVEYLDLDLDSGKS EGFR 9890893
LTP
1.00
 PTPN11 SH2 -
0.72
 - low
Y 627 IKPKGDKQVEYLDLDLDSGKS Met 10734310
LTP
1.00
 PTPN11 SH2 -
0.72
 - low
Y 627 IKPKGDKQVEYLDLDLDSGKS - 18083107
HTP
1.00
 PTPN11 SH2 -
0.72
 - low
Y 659 GSSVADERVDYVVVDQQKTLA - 10978177
LTP
1.00
 PTPN11 SH2 -
0.61
 - low
Y 659 GSSVADERVDYVVVDQQKTLA EGFR 9890893
LTP
1.00
 PTPN11 SH2 -
0.61
 - low
Y 659 GSSVADERVDYVVVDQQKTLA Met 10734310
LTP
1.00
 PTPN11 SH2 -
0.61
 - low
Y 659 GSSVADERVDYVVVDQQKTLA - 18083107
HTP
1.00
 PTPN11 SH2 -
0.61
 - low
Y 659 GSSVADERVDYVVVDQQKTLA - 18669648
HTP
1.00
 PTPN11 SH2 -
0.61
 - low

Substrate: Gab2 (Adaptor molecule)
Seq-ID: Q9UQC2 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-14688   SHC1_HUMAN
MINT-56633   MK03_HUMAN
MINT-68496   P85A_HUMAN
MINT-7220613   GRB2_HUMAN
MINT-7300434   1433B_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphatidylinositol-3,4-bisphosphate binding,
phosphatidylinositol-3,4,5-trisphosphate binding,
transmembrane receptor protein tyrosine kinase adaptor protein activity		 plasma membrane,
cytoplasm		 positive regulation of cell proliferation,
phosphoinositide-mediated signaling,
positive regulation of mast cell degranulation,
osteoclast differentiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 614 APKKSTGSVDYLALDFQPSSP ZAP70 11572860
LTP
0.96
 PTPN11 SH2;
SHC1 SH2		 -
0.69
 - low
Y 643 SSVTSDEKVDYVQVDKEKTQA - 15170389
LTP
1.00
 PTPN11 SH2 -
0.71
 - low

Substrate: Gab2 (Adaptor molecule)
Seq-ID: Q9Z1S8 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphatidylinositol-3,4-bisphosphate binding,
phosphatidylinositol-3,4,5-trisphosphate binding,
transmembrane receptor protein tyrosine kinase adaptor protein activity		 plasma membrane,
cytoplasm		 positive regulation of cell proliferation,
cell migration,
integrin-mediated signaling pathway,
phosphoinositide-mediated signaling,
positive regulation of mast cell degranulation,
osteoclast differentiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 603 APKKSTGSVDYLALDFQPGSP SRC_group 9885561
LTP
0.96
 PTPN11 SH2 -
0.70
 - medium
Y 632 SSVTSDEKVDYVQVDKEKTQA - 9885561
LTP
1.00
 PTPN11 SH2 -
0.71
 - medium
Y 632 SSVTSDEKVDYVQVDKEKTQA - 11640929
LTP
1.00
 PTPN11 SH2 -
0.71
 - medium

Substrate: FCGR2B (protein binding)
Seq-ID: P31994 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-74919   PTN6_HUMAN
MINT-74920   SHIP1_HUMAN
MINT-7245214   SRC_HUMAN
MINT-7247446   FYN_HUMAN
MINT-7251178   NCK1_HUMAN
MINT-7252786   PLCG1_HUMAN
MINT-7254142   CRK_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor activity,
IgG binding		 plasma membrane,
integral to membrane		 immune response,
interspecies interaction between organisms
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 292 DKVGAENTITYSLLMHPDALE Lyn 8756631
LTP
1.00
 INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2		 -
0.42
 - low
Y 292 DKVGAENTITYSLLMHPDALE BLK 8756631
LTP
1.00
 INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2		 -
0.42
 - low

Substrate: c-kit (Receptor tyrosine kinase)
Seq-ID: P10721 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor signaling protein tyrosine kinase activity,
ATP binding,
protein binding		 integral to membrane,
extracellular space		 male gonad development,
transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 568 KVVEEINGNNYVYIDPTQLPY Kit 9799234
LTP
1.00
 Fyn SH2;
MATK SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2		 -
0.13
 --

Substrate: Leptin receptor (Receptor for the obesity factor Leptin; it belongs to the cytokine receptor family)
Seq-ID: P48356 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-2576222   SOCS3_MOUSE
MINT-2576447   STA5A_MOUSE
MINT-2576732   PLCG1_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cytokine receptor activity integral to plasma membrane cholesterol metabolic process,
negative regulation of hydrolase activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 985 DECQRQPSVKYATLVSNDKLV - 10799542
LTP
1.00
 PTPN11 SH2 -
0.39
 --

Substrate: CD33 (CD antigen)
Seq-ID: P20138 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
sugar binding,
receptor activity		 integral to plasma membrane negative regulation of cell proliferation,
cell-cell signaling,
cell adhesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 340 PTVEMDEELHYASLNFHGMNP - 10206955
LTP
1.00
 PTPN11 SH2;
PTPN6 SH2		 -
0.54
 - low
Y 340 PTVEMDEELHYASLNFHGMNP Lck 10887109
LTP
1.00
 PTPN11 SH2;
PTPN6 SH2		 -
0.54
 - low
Y 340 PTVEMDEELHYASLNFHGMNP SRC 10887109
LTP
1.00
 PTPN11 SH2;
PTPN6 SH2		 -
0.54
 - low

Substrate: p62DOK (Docking protein, common target of PTKs)
Seq-ID: Q99704 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-74512   ERBB2_HUMAN
MINT-7974670   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
insulin receptor binding cytosol,
perinuclear region of cytoplasm		 transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 337 GEGVQRKKPLYWDLYEHAQQQ - 16497976
HTP
1.00
 CRKL SH2;
PTPN11 SH2		 -
0.48
 --

Substrate: EGFR (Receptor for EGF and other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor,)
Seq-ID: P00533 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16802   GRB10_HUMAN
MINT-50935   1433Z_HUMAN
MINT-51101   ANXA1_HUMAN
MINT-51490   ARBK1_HUMAN
MINT-60973   CBL_HUMAN
MINT-61486   CRKL_HUMAN
MINT-61487   CSK_HUMAN
MINT-61490   STA5B_HUMAN
MINT-61540   GRB2_HUMAN
MINT-68514   PDC6I_HUMAN
MINT-74427   ABL1_HUMAN
MINT-74438   ABL2_HUMAN
MINT-74460   ANS1A_HUMAN
MINT-74469   APBB1_HUMAN
MINT-74479   DP13A_HUMAN
MINT-74487   BMX_HUMAN
MINT-74497   CRK_HUMAN
MINT-74535   FES_HUMAN
MINT-74551   IRS1_HUMAN
MINT-74555   IRS4_HUMAN
MINT-74562   JAK2_HUMAN
MINT-74566   SH2B3_HUMAN
MINT-74572   JIP1_HUMAN
MINT-74587   NCK1_HUMAN
MINT-74593   NUMB_HUMAN
MINT-74594   NUMBL_HUMAN
MINT-74606   P85A_HUMAN
MINT-74630   P85B_HUMAN
MINT-74659   P55G_HUMAN
MINT-74678   PLCG1_HUMAN
MINT-74685   PLCG2_HUMAN
MINT-74687   PTK6_HUMAN
MINT-74689   PTN11_HUMAN
MINT-74711   RASA1_HUMAN
MINT-74717   SH2B1_HUMAN
MINT-74720   SH22A_HUMAN
MINT-74732   SHC1_HUMAN
MINT-74746   SLAP1_HUMAN
MINT-74763   KSYK_HUMAN
MINT-74790   TLN1_HUMAN
MINT-74807   ZAP70_HUMAN
MINT-1788719   ERBB2_HUMAN
MINT-6169667   ESR1_HUMAN
MINT-6170031   SOS1_MOUSE
MINT-6170198   SH3G2_HUMAN
MINT-6170268   SH3K1_HUMAN
MINT-6793358   PTN1_HUMAN
MINT-7980526   TM1L1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
epidermal growth factor receptor activity,
protein heterodimerization activity,
identical protein binding,
receptor signaling protein tyrosine kinase activity,
double-stranded DNA binding,
ATP binding,
protein phosphatase binding,
actin filament binding,
MAP/ERK kinase kinase activity		 Shc-EGFR complex,
endosome,
basolateral plasma membrane,
integral to membrane,
extracellular space,
nucleus		 activation of phospholipase C activity,
protein insertion into membrane,
response to UV-A,
positive regulation of nitric oxide biosynthetic process,
positive regulation of cell migration,
positive regulation of cyclin-dependent protein kinase activity involved in G1/S,
positive regulation of catenin protein nuclear translocation,
regulation of nitric-oxide synthase activity,
positive regulation of protein kinase B signaling cascade,
ossification,
positive regulation of epithelial cell proliferation,
activation of phospholipase A2 activity by calcium-mediated signaling,
cell-cell adhesion,
regulation of peptidyl-tyrosine phosphorylation,
positive regulation of phosphorylation,
positive regulation of MAP kinase activity,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 978 FSKMARDPQRYLVIQGDERMH - 16097034
HTP
1.00
 PTPN11 SH2 -
0.35
 3BEL 4.37%

Substrate: Epo-R (Receptor for erythropoietin, a major activator of erythropoiesis)
Seq-ID: P19235 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-73504   PTN6_HUMAN
MINT-74896   PTN6_MOUSE
MINT-6794748   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
erythropoietin receptor activity extracellular region,
integral to plasma membrane
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 426 PEGASAASFEYTILDPSSQLL - 10579919
LTP
1.00
 CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2		 -
0.45
 - low
Y 426 PEGASAASFEYTILDPSSQLL - 12027890
LTP
1.00
 CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2		 -
0.45
 - low
Y 426 PEGASAASFEYTILDPSSQLL - 12441334
LTP
1.00
 CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2		 -
0.45
 - low
Y 426 PEGASAASFEYTILDPSSQLL - 10660611
LTP
1.00
 CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2		 -
0.45
 - low

Substrate: IGF1-R (Receptor tyrosine kinase)
Seq-ID: P08069 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-15644   GRB10_HUMAN
MINT-18053   IRS2_HUMAN
MINT-1774754   ARHGC_MOUSE
MINT-1774976   ARHGC_HUMAN
MINT-6800783   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoinositide 3-kinase binding,
identical protein binding,
insulin-like growth factor receptor activity,
insulin binding,
metal ion binding,
insulin receptor binding,
insulin receptor substrate binding,
ATP binding,
insulin-like growth factor I binding		 microsome,
integral to plasma membrane		 positive regulation of DNA replication,
positive regulation of cell proliferation,
positive regulation of cell migration,
anti-apoptosis,
phosphoinositide 3-kinase cascade,
phosphoinositide-mediated signaling,
immune response,
protein amino acid autophosphorylation,
insulin receptor signaling pathway,
protein tetramerization
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1161 IGDFGMTRDIYETDYYRKGGK IGF1R 8550552
LTP
1.00
 PTPN11 SH2 TyrKc
0.16
 1P4O 3.49%
Y 1161 IGDFGMTRDIYETDYYRKGGK IGF1R 8940173
LTP
1.00
 PTPN11 SH2 TyrKc
0.16
 1P4O 3.49%
Y 1161 IGDFGMTRDIYETDYYRKGGK SRC 8940173
LTP
1.00
 PTPN11 SH2 TyrKc
0.16
 1P4O 3.49%
Y 1161 IGDFGMTRDIYETDYYRKGGK - 18083107
HTP
1.00
 PTPN11 SH2 TyrKc
0.16
 1P4O 3.49%
Y 1165 GMTRDIYETDYYRKGGKGLLP IGF1R 8550552
LTP
1.00
 PTPN11 SH2 TyrKc
0.16
 1P4O 17.03%
Y 1165 GMTRDIYETDYYRKGGKGLLP IGF1R 8940173
LTP
1.00
 PTPN11 SH2 TyrKc
0.16
 1P4O 17.03%
Y 1165 GMTRDIYETDYYRKGGKGLLP SRC 8940173
LTP
1.00
 PTPN11 SH2 TyrKc
0.16
 1P4O 17.03%
Y 1165 GMTRDIYETDYYRKGGKGLLP - 18083107
HTP
1.00
 PTPN11 SH2 TyrKc
0.16
 1P4O 17.03%
Y 1166 MTRDIYETDYYRKGGKGLLPV IGF1R 8550552
LTP
1.00
 PTPN11 SH2 TyrKc
0.14
 1P4O 24.45%
Y 1166 MTRDIYETDYYRKGGKGLLPV IGF1R 8940173
LTP
1.00
 PTPN11 SH2 TyrKc
0.14
 1P4O 24.45%
Y 1166 MTRDIYETDYYRKGGKGLLPV SRC 8940173
LTP
1.00
 PTPN11 SH2 TyrKc
0.14
 1P4O 24.45%
Y 1166 MTRDIYETDYYRKGGKGLLPV - 18083107
HTP
1.00
 PTPN11 SH2 TyrKc
0.14
 1P4O 24.45%
Y 1346 LRASFDERQPYAHMNGGRKNE IGF1R 8550552
LTP
1.00
 Csk SH2;
GRB10 SH2;
PIK3R1 SH2;
PTPN11 SH2		 -
0.63
 --

Substrate: IL-4R alpha (Cytokin receptor)
Seq-ID: P24394 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
MINT-63292   ARI2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor signaling protein activity,
interleukin-4 receptor activity		 extracellular region,
integral to plasma membrane		 immune response
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 713 LVDSLGSGIVYSALTCHLCGH - 9670964
LTP
1.00
 INPP5D SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2		 -
0.17
 - medium

Substrate: IL-6R (gp130) (gp130 is shared by members of the IL-6 family)
Seq-ID: P40189 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
ciliary neurotrophic factor receptor activity,
protein homodimerization activity,
interleukin-27 receptor activity,
ciliary neurotrophic factor receptor binding		 extracellular region,
oncostatin-M receptor complex,
interleukin-6 receptor complex,
extracellular space,
ciliary neurotrophic factor receptor complex		 positive regulation vascular endothelial growth factor production,
positive regulation of tyrosine phosphorylation of Stat3 protein,
positive regulation of anti-apoptosis,
leukemia inhibitory factor signaling pathway,
response to cytokine stimulus,
negative regulation of interleukin-6-mediated signaling pathway,
positive regulation of tyrosine phosphorylation of Stat1 protein,
positive regulation of adaptive immune response,
ciliary neurotrophic factor-mediated signaling pathway,
positive regulation of T cell proliferation,
positive regulation of osteoblast differentiation,
interleukin-27-mediated signaling pathway,
positive regulation of acute inflammatory response,
positive regulation of cardiac muscle hypertrophy
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 759 SSQNTSSTVQYSTVVHSGYRH - 8934572
LTP
1.00
 PTPN11 SH2;
SOCS3 SH2;
STAT5 SH2		 -
0.61
 - medium
Y 759 SSQNTSSTVQYSTVVHSGYRH - 9505191
LTP
1.00
 PTPN11 SH2;
SOCS3 SH2;
STAT5 SH2		 -
0.61
 - medium

Substrate: Protein zero related protein (Immunoglobulin)
Seq-ID: O95297 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
structural molecule activity,
protein binding		 integral to plasma membrane cell-cell signaling,
transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 241 PSGSHQGPVIYAQLDHSGGHH - 10681522
LTP
1.00
 PTPN11 SH2 -
0.48
 - low
Y 241 PSGSHQGPVIYAQLDHSGGHH SRC 11751924
LTP
1.00
 PTPN11 SH2 -
0.48
 - low
Y 241 PSGSHQGPVIYAQLDHSGGHH - 18083107
HTP
1.00
 PTPN11 SH2 -
0.48
 - low
Y 263 DKINKSESVVYADIRKN     - 10681522
LTP
0.11
 PTPN11 SH2 -
0.37
 - low
Y 263 DKINKSESVVYADIRKN     SRC 11751924
LTP
0.11
 PTPN11 SH2 -
0.37
 - low
Y 263 DKINKSESVVYADIRKN     - 18083107
HTP
0.11
 PTPN11 SH2 -
0.37
 - low
Y 263 DKINKSESVVYADIRKN     - 18669648
HTP
0.11
 PTPN11 SH2 -
0.37
 - low

Substrate: PYK2 (Focal adhesion kinase 2)
Seq-ID: Q14289 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-68515   PDC6I_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
signal transducer activity		 positive regulation of cell proliferation,
signal complex assembly,
apoptosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 881 ANLDRTDDLVYLNVMELVRAV - 10880513
LTP
1.00
 GRB2 SH2;
PTPN11 SH2		 Focal_AT
0.23
 3GM1 24.02%

Substrate: PDGF-R beta (Beta platelet-derived growth factor receptor)
Seq-ID: P09619 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-2832596   NHRF2_HUMAN
MINT-2832984   PTEN_HUMAN
MINT-2833042   NHRF1_HUMAN
MINT-6762380   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
vascular endothelial growth factor receptor activity,
platelet-derived growth factor binding,
platelet activating factor receptor activity,
platelet-derived growth factor receptor binding,
ATP binding,
platelet-derived growth factor beta-receptor activity		 integral to plasma membrane positive regulation of cell proliferation,
positive regulation of cell migration,
protein amino acid autophosphorylation,
peptidyl-tyrosine phosphorylation,
cell chemotaxis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 579 IESVSSDGHEYIYVDPMQLPY PDGFR_beta 8195171
LTP
1.00
 Fyn SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2;
SLA SH2;
Src SH2;
STAT5 SH2;
YES1 SH2		 -
0.15
 - medium
Y 581 SVSSDGHEYIYVDPMQLPYDS PDGFR_beta 8617789
LTP
1.00
 Fyn SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2;
RASA_group SH2;
SLA SH2;
Src SH2;
STAT5 SH2;
YES1 SH2		 -
0.16
 - medium
Y 763 PMLDMKGDVKYADIESSNYMA - 10821867
LTP
0.28
 PTPN11 SH2 TyrKc
0.21
 - medium
Y 763 PMLDMKGDVKYADIESSNYMA PDGFR_beta N.N.
LTP
0.28
 PTPN11 SH2 TyrKc
0.21
 - medium
Y 763 PMLDMKGDVKYADIESSNYMA PDGFR_beta 10391677
LTP
0.28
 PTPN11 SH2 TyrKc
0.21
 - medium
Y 1009 RSPLDTSSVLYTAVQPNEGDN PDGFR_beta 8195171
LTP
0.02
 NCK SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2		 -
0.61
 - medium
Y 1021 AVQPNEGDNDYIIPLPDPKPE PDGFR_beta 12062403
LTP
1.00
 PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2		 -
0.75
 - medium

Substrate: TIE2 (TEK) (PTK receptor for angiopoietin 1)
Seq-ID: Q02763 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transmembrane receptor protein tyrosine kinase activity,
ATP binding,
protein binding		 basolateral plasma membrane,
integral to plasma membrane,
cell surface,
microvillus,
apical plasma membrane,
membrane raft		 positive regulation of ERK1 and ERK2 cascade,
protein amino acid phosphorylation,
protein oligomerization,
cell-cell signaling,
positive regulation of protein kinase B signaling cascade,
regulation of cell proliferation,
transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 897 NLLGACEHRGYLYLAIEYAPH - 11080633
LTP
1.00
 PIK3R1 SH2;
PTPN11 SH2		 TyrKc
0.05
 1FVR 36.24%
Y 897 NLLGACEHRGYLYLAIEYAPH - 11513602
LTP
1.00
 PIK3R1 SH2;
PTPN11 SH2		 TyrKc
0.05
 1FVR 36.24%
Y 1113 VNTTLYEKFTYAGIDCSAEEA TIE2 10521483
LTP
1.00
 PIK3R1 SH2;
PTPN11 SH2		 -
0.12
 1FVR 15.72%
Y 1113 VNTTLYEKFTYAGIDCSAEEA - 12665569
LTP
1.00
 PIK3R1 SH2;
PTPN11 SH2		 -
0.12
 1FVR 15.72%

Substrate: VEGFR-1 (Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity.)
Seq-ID: P17948 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-6177086   LDLR_HUMAN
MINT-6539646   CBL_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
vascular endothelial growth factor receptor activity,
ATP binding,
growth factor binding		 cytoplasm,
integral to plasma membrane,
extracellular space		 positive regulation of vascular endothelial growth factor receptor signaling pathway,
female pregnancy,
peptidyl-tyrosine phosphorylation,
cell differentiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1213 FNSGSSDDVRYVNAFKFMSLE FLT1 11513746
LTP
1.00
 GRB2 SH2;
NCK SH2;
PIK3R1 SH2;
PTPN11 SH2		 -
0.20
 - low
Y 1213 FNSGSSDDVRYVNAFKFMSLE FLT1 9722576
LTP
1.00
 GRB2 SH2;
NCK SH2;
PIK3R1 SH2;
PTPN11 SH2		 -
0.20
 - low
Y 1213 FNSGSSDDVRYVNAFKFMSLE - 9600074
LTP
1.00
 GRB2 SH2;
NCK SH2;
PIK3R1 SH2;
PTPN11 SH2		 -
0.20
 - low

Substrate: AT1AR (G protein coupled receptor)
Seq-ID: P30556 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
MINT-4791905   ARRB1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
acetyltransferase activator activity,
angiotensin type II receptor activity,
protein heterodimerization activity,
bradykinin receptor binding,
angiotensin type I receptor activity		 integral to plasma membrane elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger,
regulation of cell growth,
calcium-mediated signaling,
regulation of vasoconstriction,
Rho protein signal transduction,
kidney development,
low-density lipoprotein particle remodeling,
regulation of vasodilation,
positive regulation of macrophage derived foam cell differentiation,
regulation of natriuresis,
positive regulation of NAD(P)H oxidase activity,
positive regulation of phospholipase A2 activity,
positive regulation of inflammatory response,
regulation of blood vessel size by renin-angiotensin,
oxygen and reactive oxygen species metabolic process,
regulation of cell proliferation,
renin-angiotensin regulation of aldosterone production,
cell chemotaxis,
positive regulation of cellular protein metabolic process,
positive regulation of cholesterol esterification
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 319 FKRYFLQLLKYIPPKAKSHSN - 12522132
LTP
0.05
 JAK2 SH2;
PLCG1 SH2;
PTPN11 SH2		 -
0.03
 - medium

Substrate: Insulin R (Receptor tyrosine kinase)
Seq-ID: P06213 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16516   GRB10_HUMAN
MINT-16842   MD2L1_HUMAN
MINT-18199   IRS2_HUMAN
MINT-19010   IRS1_HUMAN
MINT-73466   GRB10_MOUSE
MINT-6793537   INSR_RAT
MINT-6794075   IRS1_MOUSE
MINT-6794090   INSR_MOUSE
MINT-6794946   PTN1_HUMAN
MINT-6795115   IRS1_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
insulin-like growth factor receptor binding,
insulin binding,
PTB domain binding,
GTP binding,
metal ion binding,
insulin receptor substrate binding,
ATP binding,
insulin-like growth factor I binding,
insulin receptor activity,
SH2 domain binding,
phosphoinositide 3-kinase binding,
insulin-like growth factor II binding,
receptor signaling protein tyrosine kinase activity		 microsome,
caveola,
insulin receptor complex,
endosome membrane		 positive regulation of glycolysis,
positive regulation of MAPKKK cascade,
positive regulation of developmental growth,
regulation of embryonic development,
heart morphogenesis,
positive regulation of cell migration,
carbohydrate metabolic process,
protein heterotetramerization,
positive regulation of protein kinase B signaling cascade,
protein amino acid autophosphorylation,
activation of MAPK activity,
positive regulation of glycogen biosynthetic process,
positive regulation of mitosis,
peptidyl-tyrosine phosphorylation,
positive regulation of glucose import,
positive regulation of respiratory burst,
activation of protein kinase B activity,
G-protein coupled receptor protein signaling pathway,
positive regulation of DNA replication,
positive regulation of protein amino acid phosphorylation,
positive regulation of cell proliferation,
glucose homeostasis,
positive regulation of nitric oxide biosynthetic process,
transformation of host cell by virus,
regulation of gene-specific transcription
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1185 IGDFGMTRDIYETDYYRKGGK INSR 7806540
LTP
1.00
 GRB10 SH2;
GRB14 SH2;
PTPN11 SH2;
SH2B1 SH2;
SH2B2 SH2		 TyrKc
0.19
 1IR3 100.87%
Y 1185 IGDFGMTRDIYETDYYRKGGK - 18083107
HTP
1.00
 GRB10 SH2;
GRB14 SH2;
PTPN11 SH2;
SH2B1 SH2;
SH2B2 SH2		 TyrKc
0.19
 1IR3 100.87%
Y 1189 GMTRDIYETDYYRKGGKGLLP INSR 7806540
LTP
1.00
 GRB10 SH2;
GRB14 SH2;
PTPN11 SH2;
SH2B1 SH2;
SH2B2 SH2		 TyrKc
0.19
 1IR3 67.69%
Y 1189 GMTRDIYETDYYRKGGKGLLP - 9506989
LTP
1.00
 GRB10 SH2;
GRB14 SH2;
PTPN11 SH2;
SH2B1 SH2;
SH2B2 SH2		 TyrKc
0.19
 1IR3 67.69%
Y 1189 GMTRDIYETDYYRKGGKGLLP - 18083107
HTP
1.00
 GRB10 SH2;
GRB14 SH2;
PTPN11 SH2;
SH2B1 SH2;
SH2B2 SH2		 TyrKc
0.19
 1IR3 67.69%
Y 1190 MTRDIYETDYYRKGGKGLLPV INSR 7806540
LTP
1.00
 GRB10 SH2;
PTPN11 SH2;
SH2B1 SH2		 TyrKc
0.17
 1IR3 44.54%
Y 1190 MTRDIYETDYYRKGGKGLLPV - 9506989
LTP
1.00
 GRB10 SH2;
PTPN11 SH2;
SH2B1 SH2		 TyrKc
0.17
 1IR3 44.54%
Y 1190 MTRDIYETDYYRKGGKGLLPV - 18083107
HTP
1.00
 GRB10 SH2;
PTPN11 SH2;
SH2B1 SH2		 TyrKc
0.17
 1IR3 44.54%
Y 1361 FKRSYEEHIPYTHMNGGKKNG INSR 1321605
LTP
0.95
 Csk SH2;
GRB10 SH2;
PIK3R1 SH2;
PTPN11 SH2;
SHC1 SH2		 -
0.54
 --

Substrate: CD150 (T cell antigen receptor)
Seq-ID: Q13291 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
antigen binding,
transmembrane receptor activity		 integral to membrane positive regulation of cell proliferation,
lymphocyte activation,
interspecies interaction between organisms
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 281 TTVEKKSLTIYAQVQKPGPLQ Fyn 11806999
LTP
1.00
 FGR SH2;
INPP5D SH2;
PTPN11 SH2;
SH2D1A SH2;
SH2D1B SH2		 -
0.39
 - low
Y 281 TTVEKKSLTIYAQVQKPGPLQ - 18083107
HTP
1.00
 FGR SH2;
INPP5D SH2;
PTPN11 SH2;
SH2D1A SH2;
SH2D1B SH2		 -
0.39
 - low
Y 307 FPAQDPCTTIYVAATEPVPES Fyn 11806999
LTP
1.00
 INPP5D SH2;
PTPN11 SH2;
SH2D1A SH2;
SH2D1B SH2		 -
0.40
 - low
Y 307 FPAQDPCTTIYVAATEPVPES Lck 11806999
LTP
1.00
 INPP5D SH2;
PTPN11 SH2;
SH2D1A SH2;
SH2D1B SH2		 -
0.40
 - low
Y 327 SVQETNSITVYASVTLPES   Fyn 11806999
LTP
1.00
 FGR SH2;
INPP5D SH2;
PTPN11 SH2;
SH2D1A SH2;
SH2D1B SH2		 -
0.38
 - low
Y 327 SVQETNSITVYASVTLPES   Lyn 15315965
LTP
1.00
 FGR SH2;
INPP5D SH2;
PTPN11 SH2;
SH2D1A SH2;
SH2D1B SH2		 -
0.38
 - low

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