List of substrates found:

Band 3 anion transport protein  Bcr  Insulin receptor substrate 1  Integrin beta 3  CTLA-4  Common beta c subunit  LAIR1  STAT 5  PDGF-R alpha  CD31  G-CSF-R  Gab1  Gab2  FCGR2B  c-kit  Leptin receptor  CD33  p62DOK  EGFR  Epo-R  IGF1-R  IL-4R alpha  IL-6R (gp130)  Protein zero related protein  PYK2  PDGF-R beta  TIE2 (TEK)  VEGFR-1  AT1AR  Insulin R  CD150 


Substrate: Band 3 anion transport protein (Anion exchange protein 1)
Seq-ID: P02730 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 359 SSPAKPDSSFYKGLDLNGGPD Lyn 10942405
LTP
0.11
PTPN11 SH2 -
0.45
--
Y 359 SSPAKPDSSFYKGLDLNGGPD SYK 10942405
LTP
0.11
PTPN11 SH2 -
0.45
--
Y 359 SSPAKPDSSFYKGLDLNGGPD - 18083107
HTP
0.11
PTPN11 SH2 -
0.45
--

Substrate: Bcr (Breakpoint cluster region protein)
Seq-ID: P11274 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 177 QPGADAEKPFYVNVEFHHERG Fes 8955135
LTP
0.75
ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2
-
0.68
- medium
Y 177 QPGADAEKPFYVNVEFHHERG Fes 10405761
LTP
0.75
ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2
-
0.68
- medium
Y 177 QPGADAEKPFYVNVEFHHERG - 12522270
HTP
0.75
ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2
-
0.68
- medium
Y 177 QPGADAEKPFYVNVEFHHERG - 9178913
LTP
0.75
ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2
-
0.68
- medium
Y 177 QPGADAEKPFYVNVEFHHERG - 12124177
LTP
0.75
ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2
-
0.68
- medium
Y 177 QPGADAEKPFYVNVEFHHERG - 9407116
LTP
0.75
ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2
-
0.68
- medium
Y 177 QPGADAEKPFYVNVEFHHERG Abl 16912036
LTP
0.75
ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2
-
0.68
- medium
Y 177 QPGADAEKPFYVNVEFHHERG HCK 16912036
LTP
0.75
ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2
-
0.68
- medium
Y 177 QPGADAEKPFYVNVEFHHERG - 18083107
HTP
0.75
ABL1 SH2;
FES SH2;
GRAP SH2;
GRB2 SH2;
PTPN11 SH2
-
0.68
- medium

Substrate: Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID: P35568 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 662 RHPQRVDPNGYMMMSPSGGCS - 15592455
HTP
1.00
Fyn SH2;
MATK SH2;
PIK3R1 SH2;
PTPN11 SH2
-
0.77
--
Y 896 HPPEPKSPGEYVNIEFGSDQS - 11259577
LTP
1.00
GRB2 SH2;
PTPN11 SH2
-
0.76
--

Substrate: Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID: P35570 [Rattus norvegicus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1172 AAGGLEKSLNYIDLDLVKDVK INSR 7504175
LTP
1.00
PTPN11 SH2 -
0.48
- medium
Y 1172 AAGGLEKSLNYIDLDLVKDVK IGF1R 11572799
LTP
1.00
PTPN11 SH2 -
0.48
- medium
Y 1172 AAGGLEKSLNYIDLDLVKDVK INSR 11572799
LTP
1.00
PTPN11 SH2 -
0.48
- medium
Y 1222 PRRSSEDLSTYASINFQKQPE INSR 7504175
LTP
0.09
PTPN11 SH2 -
0.77
- medium
Y 1222 PRRSSEDLSTYASINFQKQPE - 12220227
LTP
0.09
PTPN11 SH2 -
0.77
- medium

Substrate: Integrin beta 3 (Platelet membrane glycoprotein IIIa)
Seq-ID: P05106 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 773 AKWDTANNPLYKEATSTFTNI - 8631894
LTP
1.00
GRB2 SH2;
PTPN11 SH2;
SHC1 PTB;
TLN1 PTB
Integrin_b_cyt
0.26
--
Y 773 AKWDTANNPLYKEATSTFTNI SRC 15699036
LTP
1.00
GRB2 SH2;
PTPN11 SH2;
SHC1 PTB;
TLN1 PTB
Integrin_b_cyt
0.26
--
Y 773 AKWDTANNPLYKEATSTFTNI - 18088087
HTP
1.00
GRB2 SH2;
PTPN11 SH2;
SHC1 PTB;
TLN1 PTB
Integrin_b_cyt
0.26
--
Y 773 AKWDTANNPLYKEATSTFTNI SRC 18398066
LTP
1.00
GRB2 SH2;
PTPN11 SH2;
SHC1 PTB;
TLN1 PTB
Integrin_b_cyt
0.26
--
Y 785 EATSTFTNITYRGT        SYK 8631894
LTP
0.98
PTPN11 SH2;
SHC1 PTB;
SYK SH2
Integrin_b_cyt
0.26
--
Y 785 EATSTFTNITYRGT        SRC 8631894
LTP
0.98
PTPN11 SH2;
SHC1 PTB;
SYK SH2
Integrin_b_cyt
0.26
--
Y 785 EATSTFTNITYRGT        - 18088087
HTP
0.98
PTPN11 SH2;
SHC1 PTB;
SYK SH2
Integrin_b_cyt
0.26
--

Substrate: CTLA-4 (CD152 antigen)
Seq-ID: P16410 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 201 KKRSPLTTGVYVKMPPTEPEC JAK2 10842319
LTP
1.00
PIK3R1 SH2;
PTPN11 SH2
-
0.37
- low
Y 201 KKRSPLTTGVYVKMPPTEPEC TXK 9813138
LTP
1.00
PIK3R1 SH2;
PTPN11 SH2
-
0.37
- low

Substrate: Common beta c subunit (Cytokine recpetor common beta chain)
Seq-ID: P32927 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 593 QASSFDFNGPYLGPPHSRSLP - 9257712
LTP
1.00
PTPN11 SH2;
SHC1 PTB;
SHC_group SH2
-
0.76
- medium
Y 593 QASSFDFNGPYLGPPHSRSLP - 10362354
LTP
1.00
PTPN11 SH2;
SHC1 PTB;
SHC_group SH2
-
0.76
- medium
Y 628 QKSPPPGSLEYLCLPAGGQVQ - 9257712
LTP
1.00
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2;
STAT5 SH2
-
0.71
- medium
Y 628 QKSPPPGSLEYLCLPAGGQVQ - 10362354
LTP
1.00
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2;
STAT5 SH2
-
0.71
- medium
Y 766 PGPVKSGFEGYVELPPIEGRS - 9257712
LTP
1.00
PTPN11 SH2;
SHC1 SH2;
SHC_group SH2;
STAT5 SH2
-
0.69
- medium

Substrate: LAIR1 (Cell surface receptor)
Seq-ID: Q6GTX8 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor activity,
protein binding
plasma membrane,
integral to membrane
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 251 LAAGSSQEVTYAQLDHWALTQ - 10764762
LTP
0.28
PTPN11 SH2;
PTPN6 SH2
-
0.33
- low

Substrate: STAT 5 (Transcription factor)
Seq-ID: P42229 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 694 TPVLAKAVDGYVKPQIKQVVP Lyn 11641791
LTP
0.25
CRKL SH2;
PTPN11 SH2;
STAT5 SH2
SH2
0.20
- medium
Y 694 TPVLAKAVDGYVKPQIKQVVP SRC 11641791
LTP
0.25
CRKL SH2;
PTPN11 SH2;
STAT5 SH2
SH2
0.20
- medium
Y 694 TPVLAKAVDGYVKPQIKQVVP JAK2 11641791
LTP
0.25
CRKL SH2;
PTPN11 SH2;
STAT5 SH2
SH2
0.20
- medium
Y 694 TPVLAKAVDGYVKPQIKQVVP - 17081983
HTP
0.25
CRKL SH2;
PTPN11 SH2;
STAT5 SH2
SH2
0.20
- medium
Y 694 TPVLAKAVDGYVKPQIKQVVP - 18083107
HTP
0.25
CRKL SH2;
PTPN11 SH2;
STAT5 SH2
SH2
0.20
- medium

Substrate: PDGF-R alpha (Receptor tyrosine kinase)
Seq-ID: P16234 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 720 LNPADESTRSYVILSFENNGD - 11818394
LTP
0.21
PTPN11 SH2;
SHB SH2
TyrKc
0.29
- medium
Y 754 PMLERKEVSKYSDIQRSLYDR PDGFR_alpha 7523122
LTP
0.27
PTPN11 SH2 TyrKc
0.29
- medium

Substrate: CD31 (Adhesion molecule)
Seq-ID: P16284 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 690 NKEPLNSDVQYTEVQVSSAES - 15201144
LTP
1.00
INPP5D SH2;
PLCG1 SH2;
PTPN11 SH2;
PTPN6 SH2;
Src SH2
-
0.58
- medium
Y 713 DLGKKDTETVYSEVRKAVPDA - 15592455
HTP
1.00
PLCG1 SH2;
PTPN11 SH2;
PTPN6 SH2;
Src SH2
-
0.63
- medium
Y 713 DLGKKDTETVYSEVRKAVPDA - 18088087
HTP
1.00
PLCG1 SH2;
PTPN11 SH2;
PTPN6 SH2;
Src SH2
-
0.63
- medium
Y 713 DLGKKDTETVYSEVRKAVPDA - 18083107
HTP
1.00
PLCG1 SH2;
PTPN11 SH2;
PTPN6 SH2;
Src SH2
-
0.63
- medium

Substrate: G-CSF-R (Granulocyte colony stimulating factor receptor)
Seq-ID: P40223 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cytokine receptor activity integral to membrane neutrophil chemotaxis,
cell adhesion
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 728 NGSLPALVQAYVLQGDPREIS - 8608222
LTP
1.00
PTPN11 SH2;
STAT3 SH2
-
0.41
- medium
Y 728 NGSLPALVQAYVLQGDPREIS - 10329697
LTP
1.00
PTPN11 SH2;
STAT3 SH2
-
0.41
- medium
Y 788 LGGPTPSPKSYENIWFHSRPQ - 8608222
LTP
1.00
GRB2 SH2;
PTPN11 SH2;
SHC_group SH2
-
0.60
- medium

Substrate: Gab1 (Multisubstrate docking protein downstream in the signaling pathways of different RTK.)
Seq-ID: Q13480 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 447 SVSSEELDENYVPMNPNSPPR INSR 10978177
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2;
PTPN11 SH2
-
0.83
- low
Y 447 SVSSEELDENYVPMNPNSPPR EGFR 9890893
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2;
PTPN11 SH2
-
0.83
- low
Y 447 SVSSEELDENYVPMNPNSPPR Met 10734310
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2;
PTPN11 SH2
-
0.83
- low
Y 589 SSDSHDSEENYVPMNPNLSSE INSR 10978177
LTP
1.00
PIK3R1 SH2;
PTPN11 SH2
-
0.89
- low
Y 589 SSDSHDSEENYVPMNPNLSSE EGFR 9890893
LTP
1.00
PIK3R1 SH2;
PTPN11 SH2
-
0.89
- low
Y 589 SSDSHDSEENYVPMNPNLSSE Met 10734310
LTP
1.00
PIK3R1 SH2;
PTPN11 SH2
-
0.89
- low
Y 627 IKPKGDKQVEYLDLDLDSGKS INSR 10978177
LTP
1.00
PTPN11 SH2 -
0.72
- low
Y 627 IKPKGDKQVEYLDLDLDSGKS EGFR 9890893
LTP
1.00
PTPN11 SH2 -
0.72
- low
Y 627 IKPKGDKQVEYLDLDLDSGKS Met 10734310
LTP
1.00
PTPN11 SH2 -
0.72
- low
Y 627 IKPKGDKQVEYLDLDLDSGKS - 18083107
HTP
1.00
PTPN11 SH2 -
0.72
- low
Y 659 GSSVADERVDYVVVDQQKTLA - 10978177
LTP
1.00
PTPN11 SH2 -
0.61
- low
Y 659 GSSVADERVDYVVVDQQKTLA EGFR 9890893
LTP
1.00
PTPN11 SH2 -
0.61
- low
Y 659 GSSVADERVDYVVVDQQKTLA Met 10734310
LTP
1.00
PTPN11 SH2 -
0.61
- low
Y 659 GSSVADERVDYVVVDQQKTLA - 18083107
HTP
1.00
PTPN11 SH2 -
0.61
- low
Y 659 GSSVADERVDYVVVDQQKTLA - 18669648
HTP
1.00
PTPN11 SH2 -
0.61
- low

Substrate: Gab2 (Adaptor molecule)
Seq-ID: Q9UQC2 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 614 APKKSTGSVDYLALDFQPSSP ZAP70 11572860
LTP
0.96
PTPN11 SH2;
SHC1 SH2
-
0.69
- low
Y 643 SSVTSDEKVDYVQVDKEKTQA - 15170389
LTP
1.00
PTPN11 SH2 -
0.71
- low

Substrate: Gab2 (Adaptor molecule)
Seq-ID: Q9Z1S8 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 603 APKKSTGSVDYLALDFQPGSP SRC_group 9885561
LTP
0.96
PTPN11 SH2 -
0.70
- medium
Y 632 SSVTSDEKVDYVQVDKEKTQA - 9885561
LTP
1.00
PTPN11 SH2 -
0.71
- medium
Y 632 SSVTSDEKVDYVQVDKEKTQA - 11640929
LTP
1.00
PTPN11 SH2 -
0.71
- medium

Substrate: FCGR2B (protein binding)
Seq-ID: P31994 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 292 DKVGAENTITYSLLMHPDALE Lyn 8756631
LTP
1.00
INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2
-
0.42
- low
Y 292 DKVGAENTITYSLLMHPDALE BLK 8756631
LTP
1.00
INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2
-
0.42
- low

Substrate: c-kit (Receptor tyrosine kinase)
Seq-ID: P10721 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 568 KVVEEINGNNYVYIDPTQLPY Kit 9799234
LTP
1.00
Fyn SH2;
MATK SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2
-
0.13
--

Substrate: Leptin receptor (Receptor for the obesity factor Leptin; it belongs to the cytokine receptor family)
Seq-ID: P48356 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 985 DECQRQPSVKYATLVSNDKLV - 10799542
LTP
1.00
PTPN11 SH2 -
0.39
--

Substrate: CD33 (CD antigen)
Seq-ID: P20138 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 340 PTVEMDEELHYASLNFHGMNP - 10206955
LTP
1.00
PTPN11 SH2;
PTPN6 SH2
-
0.54
- low
Y 340 PTVEMDEELHYASLNFHGMNP Lck 10887109
LTP
1.00
PTPN11 SH2;
PTPN6 SH2
-
0.54
- low
Y 340 PTVEMDEELHYASLNFHGMNP SRC 10887109
LTP
1.00
PTPN11 SH2;
PTPN6 SH2
-
0.54
- low

Substrate: p62DOK (Docking protein, common target of PTKs)
Seq-ID: Q99704 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 337 GEGVQRKKPLYWDLYEHAQQQ - 16497976
HTP
1.00
CRKL SH2;
PTPN11 SH2
-
0.48
--

Substrate: EGFR (Receptor for EGF and other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor,)
Seq-ID: P00533 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 978 FSKMARDPQRYLVIQGDERMH - 16097034
HTP
1.00
PTPN11 SH2 -
0.35
3BEL 4.37%

Substrate: Epo-R (Receptor for erythropoietin, a major activator of erythropoiesis)
Seq-ID: P19235 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
erythropoietin receptor activity extracellular region,
integral to plasma membrane
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 426 PEGASAASFEYTILDPSSQLL - 10579919
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2
-
0.45
- low
Y 426 PEGASAASFEYTILDPSSQLL - 12027890
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2
-
0.45
- low
Y 426 PEGASAASFEYTILDPSSQLL - 12441334
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2
-
0.45
- low
Y 426 PEGASAASFEYTILDPSSQLL - 10660611
LTP
1.00
CISH SH2;
INPP5D SH2;
PLCG2 SH2;
PTPN11 SH2;
SHC2 SH2;
SOCS2 SH2;
SOCS3 SH2;
SOCS_group SH2;
STAT5 SH2;
SYK SH2
-
0.45
- low

Substrate: IGF1-R (Receptor tyrosine kinase)
Seq-ID: P08069 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1161 IGDFGMTRDIYETDYYRKGGK IGF1R 8550552
LTP
1.00
PTPN11 SH2 TyrKc
0.16
1P4O 3.49%
Y 1161 IGDFGMTRDIYETDYYRKGGK IGF1R 8940173
LTP
1.00
PTPN11 SH2 TyrKc
0.16
1P4O 3.49%
Y 1161 IGDFGMTRDIYETDYYRKGGK SRC 8940173
LTP
1.00
PTPN11 SH2 TyrKc
0.16
1P4O 3.49%
Y 1161 IGDFGMTRDIYETDYYRKGGK - 18083107
HTP
1.00
PTPN11 SH2 TyrKc
0.16
1P4O 3.49%
Y 1165 GMTRDIYETDYYRKGGKGLLP IGF1R 8550552
LTP
1.00
PTPN11 SH2 TyrKc
0.16
1P4O 17.03%
Y 1165 GMTRDIYETDYYRKGGKGLLP IGF1R 8940173
LTP
1.00
PTPN11 SH2 TyrKc
0.16
1P4O 17.03%
Y 1165 GMTRDIYETDYYRKGGKGLLP SRC 8940173
LTP
1.00
PTPN11 SH2 TyrKc
0.16
1P4O 17.03%
Y 1165 GMTRDIYETDYYRKGGKGLLP - 18083107
HTP
1.00
PTPN11 SH2 TyrKc
0.16
1P4O 17.03%
Y 1166 MTRDIYETDYYRKGGKGLLPV IGF1R 8550552
LTP
1.00
PTPN11 SH2 TyrKc
0.14
1P4O 24.45%
Y 1166 MTRDIYETDYYRKGGKGLLPV IGF1R 8940173
LTP
1.00
PTPN11 SH2 TyrKc
0.14
1P4O 24.45%
Y 1166 MTRDIYETDYYRKGGKGLLPV SRC 8940173
LTP
1.00
PTPN11 SH2 TyrKc
0.14
1P4O 24.45%
Y 1166 MTRDIYETDYYRKGGKGLLPV - 18083107
HTP
1.00
PTPN11 SH2 TyrKc
0.14
1P4O 24.45%
Y 1346 LRASFDERQPYAHMNGGRKNE IGF1R 8550552
LTP
1.00
Csk SH2;
GRB10 SH2;
PIK3R1 SH2;
PTPN11 SH2
-
0.63
--

Substrate: IL-4R alpha (Cytokin receptor)
Seq-ID: P24394 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

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Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 713 LVDSLGSGIVYSALTCHLCGH - 9670964
LTP
1.00
INPP5D SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2
-
0.17
- medium

Substrate: IL-6R (gp130) (gp130 is shared by members of the IL-6 family)
Seq-ID: P40189 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 759 SSQNTSSTVQYSTVVHSGYRH - 8934572
LTP
1.00
PTPN11 SH2;
SOCS3 SH2;
STAT5 SH2
-
0.61
- medium
Y 759 SSQNTSSTVQYSTVVHSGYRH - 9505191
LTP
1.00
PTPN11 SH2;
SOCS3 SH2;
STAT5 SH2
-
0.61
- medium

Substrate: Protein zero related protein (Immunoglobulin)
Seq-ID: O95297 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 241 PSGSHQGPVIYAQLDHSGGHH - 10681522
LTP
1.00
PTPN11 SH2 -
0.48
- low
Y 241 PSGSHQGPVIYAQLDHSGGHH SRC 11751924
LTP
1.00
PTPN11 SH2 -
0.48
- low
Y 241 PSGSHQGPVIYAQLDHSGGHH - 18083107
HTP
1.00
PTPN11 SH2 -
0.48
- low
Y 263 DKINKSESVVYADIRKN     - 10681522
LTP
0.11
PTPN11 SH2 -
0.37
- low
Y 263 DKINKSESVVYADIRKN     SRC 11751924
LTP
0.11
PTPN11 SH2 -
0.37
- low
Y 263 DKINKSESVVYADIRKN     - 18083107
HTP
0.11
PTPN11 SH2 -
0.37
- low
Y 263 DKINKSESVVYADIRKN     - 18669648
HTP
0.11
PTPN11 SH2 -
0.37
- low

Substrate: PYK2 (Focal adhesion kinase 2)
Seq-ID: Q14289 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

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Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 881 ANLDRTDDLVYLNVMELVRAV - 10880513
LTP
1.00
GRB2 SH2;
PTPN11 SH2
Focal_AT
0.23
3GM1 24.02%

Substrate: PDGF-R beta (Beta platelet-derived growth factor receptor)
Seq-ID: P09619 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 579 IESVSSDGHEYIYVDPMQLPY PDGFR_beta 8195171
LTP
1.00
Fyn SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2;
SLA SH2;
Src SH2;
STAT5 SH2;
YES1 SH2
-
0.15
- medium
Y 581 SVSSDGHEYIYVDPMQLPYDS PDGFR_beta 8617789
LTP
1.00
Fyn SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2;
RASA_group SH2;
SLA SH2;
Src SH2;
STAT5 SH2;
YES1 SH2
-
0.16
- medium
Y 763 PMLDMKGDVKYADIESSNYMA - 10821867
LTP
0.28
PTPN11 SH2 TyrKc
0.21
- medium
Y 763 PMLDMKGDVKYADIESSNYMA PDGFR_beta N.N.
LTP
0.28
PTPN11 SH2 TyrKc
0.21
- medium
Y 763 PMLDMKGDVKYADIESSNYMA PDGFR_beta 10391677
LTP
0.28
PTPN11 SH2 TyrKc
0.21
- medium
Y 1009 RSPLDTSSVLYTAVQPNEGDN PDGFR_beta 8195171
LTP
0.02
NCK SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2
-
0.61
- medium
Y 1021 AVQPNEGDNDYIIPLPDPKPE PDGFR_beta 12062403
LTP
1.00
PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2
-
0.75
- medium

Substrate: TIE2 (TEK) (PTK receptor for angiopoietin 1)
Seq-ID: Q02763 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 897 NLLGACEHRGYLYLAIEYAPH - 11080633
LTP
1.00
PIK3R1 SH2;
PTPN11 SH2
TyrKc
0.05
1FVR 36.24%
Y 897 NLLGACEHRGYLYLAIEYAPH - 11513602
LTP
1.00
PIK3R1 SH2;
PTPN11 SH2
TyrKc
0.05
1FVR 36.24%
Y 1113 VNTTLYEKFTYAGIDCSAEEA TIE2 10521483
LTP
1.00
PIK3R1 SH2;
PTPN11 SH2
-
0.12
1FVR 15.72%
Y 1113 VNTTLYEKFTYAGIDCSAEEA - 12665569
LTP
1.00
PIK3R1 SH2;
PTPN11 SH2
-
0.12
1FVR 15.72%

Substrate: VEGFR-1 (Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity.)
Seq-ID: P17948 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1213 FNSGSSDDVRYVNAFKFMSLE FLT1 11513746
LTP
1.00
GRB2 SH2;
NCK SH2;
PIK3R1 SH2;
PTPN11 SH2
-
0.20
- low
Y 1213 FNSGSSDDVRYVNAFKFMSLE FLT1 9722576
LTP
1.00
GRB2 SH2;
NCK SH2;
PIK3R1 SH2;
PTPN11 SH2
-
0.20
- low
Y 1213 FNSGSSDDVRYVNAFKFMSLE - 9600074
LTP
1.00
GRB2 SH2;
NCK SH2;
PIK3R1 SH2;
PTPN11 SH2
-
0.20
- low

Substrate: AT1AR (G protein coupled receptor)
Seq-ID: P30556 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 319 FKRYFLQLLKYIPPKAKSHSN - 12522132
LTP
0.05
JAK2 SH2;
PLCG1 SH2;
PTPN11 SH2
-
0.03
- medium

Substrate: Insulin R (Receptor tyrosine kinase)
Seq-ID: P06213 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1185 IGDFGMTRDIYETDYYRKGGK INSR 7806540
LTP
1.00
GRB10 SH2;
GRB14 SH2;
PTPN11 SH2;
SH2B1 SH2;
SH2B2 SH2
TyrKc
0.19
1IR3 100.87%
Y 1185 IGDFGMTRDIYETDYYRKGGK - 18083107
HTP
1.00
GRB10 SH2;
GRB14 SH2;
PTPN11 SH2;
SH2B1 SH2;
SH2B2 SH2
TyrKc
0.19
1IR3 100.87%
Y 1189 GMTRDIYETDYYRKGGKGLLP INSR 7806540
LTP
1.00
GRB10 SH2;
GRB14 SH2;
PTPN11 SH2;
SH2B1 SH2;
SH2B2 SH2
TyrKc
0.19
1IR3 67.69%
Y 1189 GMTRDIYETDYYRKGGKGLLP - 9506989
LTP
1.00
GRB10 SH2;
GRB14 SH2;
PTPN11 SH2;
SH2B1 SH2;
SH2B2 SH2
TyrKc
0.19
1IR3 67.69%
Y 1189 GMTRDIYETDYYRKGGKGLLP - 18083107
HTP
1.00
GRB10 SH2;
GRB14 SH2;
PTPN11 SH2;
SH2B1 SH2;
SH2B2 SH2
TyrKc
0.19
1IR3 67.69%
Y 1190 MTRDIYETDYYRKGGKGLLPV INSR 7806540
LTP
1.00
GRB10 SH2;
PTPN11 SH2;
SH2B1 SH2
TyrKc
0.17
1IR3 44.54%
Y 1190 MTRDIYETDYYRKGGKGLLPV - 9506989
LTP
1.00
GRB10 SH2;
PTPN11 SH2;
SH2B1 SH2
TyrKc
0.17
1IR3 44.54%
Y 1190 MTRDIYETDYYRKGGKGLLPV - 18083107
HTP
1.00
GRB10 SH2;
PTPN11 SH2;
SH2B1 SH2
TyrKc
0.17
1IR3 44.54%
Y 1361 FKRSYEEHIPYTHMNGGKKNG INSR 1321605
LTP
0.95
Csk SH2;
GRB10 SH2;
PIK3R1 SH2;
PTPN11 SH2;
SHC1 SH2
-
0.54
--

Substrate: CD150 (T cell antigen receptor)
Seq-ID: Q13291 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 281 TTVEKKSLTIYAQVQKPGPLQ Fyn 11806999
LTP
1.00
FGR SH2;
INPP5D SH2;
PTPN11 SH2;
SH2D1A SH2;
SH2D1B SH2
-
0.39
- low
Y 281 TTVEKKSLTIYAQVQKPGPLQ - 18083107
HTP
1.00
FGR SH2;
INPP5D SH2;
PTPN11 SH2;
SH2D1A SH2;
SH2D1B SH2
-
0.39
- low
Y 307 FPAQDPCTTIYVAATEPVPES Fyn 11806999
LTP
1.00
INPP5D SH2;
PTPN11 SH2;
SH2D1A SH2;
SH2D1B SH2
-
0.40
- low
Y 307 FPAQDPCTTIYVAATEPVPES Lck 11806999
LTP
1.00
INPP5D SH2;
PTPN11 SH2;
SH2D1A SH2;
SH2D1B SH2
-
0.40
- low
Y 327 SVQETNSITVYASVTLPES   Fyn 11806999
LTP
1.00
FGR SH2;
INPP5D SH2;
PTPN11 SH2;
SH2D1A SH2;
SH2D1B SH2
-
0.38
- low
Y 327 SVQETNSITVYASVTLPES   Lyn 15315965
LTP
1.00
FGR SH2;
INPP5D SH2;
PTPN11 SH2;
SH2D1A SH2;
SH2D1B SH2
-
0.38
- low


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