List of substrates found:

EPHB3  p56(dok-2)  EGFR  SOCS3  IGF1-R  CD5  Insulin R  Gab1  PDGF-R beta  p62DOK  EPHB2 


Substrate: EPHB3 (Receptor for member of the ephrinB family)
Seq-ID: P54753 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-58214   AFAD_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
ephrin receptor activity,
ATP binding,
protein binding		 integral to plasma membrane protein amino acid phosphorylation,
transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 614 GMKVYIDPFTYEDPNEAVREF EphB3 9674711
LTP
1.00
 CRK SH2;
Fyn SH2;
RASA_group SH2		 -
0.26
 - low

Substrate: p56(dok-2) (Adapter molecule)
Seq-ID: O60496 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
identical protein binding,
insulin receptor binding
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 271 PASLPRPDSPYSRPHDSLPPP - 10508618
LTP
0.07
 RASA_group SH2 -
0.84
 - medium
Y 299 APRPRGQEGEYAVPFDAVARS - 10508618
LTP
1.00
 RASA_group SH2 -
0.65
 - medium
Y 299 APRPRGQEGEYAVPFDAVARS - 12522270
HTP
1.00
 RASA_group SH2 -
0.65
 - medium
Y 299 APRPRGQEGEYAVPFDAVARS - 15144186
HTP
1.00
 RASA_group SH2 -
0.65
 - medium
Y 299 APRPRGQEGEYAVPFDAVARS - 15592455
HTP
1.00
 RASA_group SH2 -
0.65
 - medium
Y 299 APRPRGQEGEYAVPFDAVARS - 16094384
HTP
1.00
 RASA_group SH2 -
0.65
 - medium
Y 299 APRPRGQEGEYAVPFDAVARS - 18083107
HTP
1.00
 RASA_group SH2 -
0.65
 - medium

Substrate: EGFR (Receptor for EGF and other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor,)
Seq-ID: P00533 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16802   GRB10_HUMAN
MINT-50935   1433Z_HUMAN
MINT-51101   ANXA1_HUMAN
MINT-51490   ARBK1_HUMAN
MINT-60973   CBL_HUMAN
MINT-61486   CRKL_HUMAN
MINT-61487   CSK_HUMAN
MINT-61490   STA5B_HUMAN
MINT-61540   GRB2_HUMAN
MINT-68514   PDC6I_HUMAN
MINT-74427   ABL1_HUMAN
MINT-74438   ABL2_HUMAN
MINT-74460   ANS1A_HUMAN
MINT-74469   APBB1_HUMAN
MINT-74479   DP13A_HUMAN
MINT-74487   BMX_HUMAN
MINT-74497   CRK_HUMAN
MINT-74535   FES_HUMAN
MINT-74551   IRS1_HUMAN
MINT-74555   IRS4_HUMAN
MINT-74562   JAK2_HUMAN
MINT-74566   SH2B3_HUMAN
MINT-74572   JIP1_HUMAN
MINT-74587   NCK1_HUMAN
MINT-74593   NUMB_HUMAN
MINT-74594   NUMBL_HUMAN
MINT-74606   P85A_HUMAN
MINT-74630   P85B_HUMAN
MINT-74659   P55G_HUMAN
MINT-74678   PLCG1_HUMAN
MINT-74685   PLCG2_HUMAN
MINT-74687   PTK6_HUMAN
MINT-74689   PTN11_HUMAN
MINT-74711   RASA1_HUMAN
MINT-74717   SH2B1_HUMAN
MINT-74720   SH22A_HUMAN
MINT-74732   SHC1_HUMAN
MINT-74746   SLAP1_HUMAN
MINT-74763   KSYK_HUMAN
MINT-74790   TLN1_HUMAN
MINT-74807   ZAP70_HUMAN
MINT-1788719   ERBB2_HUMAN
MINT-6169667   ESR1_HUMAN
MINT-6170031   SOS1_MOUSE
MINT-6170198   SH3G2_HUMAN
MINT-6170268   SH3K1_HUMAN
MINT-6793358   PTN1_HUMAN
MINT-7980526   TM1L1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
epidermal growth factor receptor activity,
protein heterodimerization activity,
identical protein binding,
receptor signaling protein tyrosine kinase activity,
double-stranded DNA binding,
ATP binding,
protein phosphatase binding,
actin filament binding,
MAP/ERK kinase kinase activity		 Shc-EGFR complex,
endosome,
basolateral plasma membrane,
integral to membrane,
extracellular space,
nucleus		 activation of phospholipase C activity,
protein insertion into membrane,
response to UV-A,
positive regulation of nitric oxide biosynthetic process,
positive regulation of cell migration,
positive regulation of cyclin-dependent protein kinase activity involved in G1/S,
positive regulation of catenin protein nuclear translocation,
regulation of nitric-oxide synthase activity,
positive regulation of protein kinase B signaling cascade,
ossification,
positive regulation of epithelial cell proliferation,
activation of phospholipase A2 activity by calcium-mediated signaling,
cell-cell adhesion,
regulation of peptidyl-tyrosine phosphorylation,
positive regulation of phosphorylation,
positive regulation of MAP kinase activity,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1016 DMDDVVDADEYLIPQQGFFSS SRC 8845374
LTP
1.00
 CRK SH2;
PLCG1 SH2;
RASA_group SH2;
Src SH2		 -
0.41
 1XKK 41.92%
Y 1016 DMDDVVDADEYLIPQQGFFSS - 7680558
LTP
1.00
 CRK SH2;
PLCG1 SH2;
RASA_group SH2;
Src SH2		 -
0.41
 1XKK 41.92%
Y 1016 DMDDVVDADEYLIPQQGFFSS - 15302935
HTP
1.00
 CRK SH2;
PLCG1 SH2;
RASA_group SH2;
Src SH2		 -
0.41
 1XKK 41.92%
Y 1069 PIKEDSFLQRYSSDPTGALTE - 15302935
HTP
1.00
 PLCG1 SH2;
RASA_group SH2		 -
0.57
 --
Y 1069 PIKEDSFLQRYSSDPTGALTE - 17081983
HTP
1.00
 PLCG1 SH2;
RASA_group SH2		 -
0.57
 --
Y 1069 PIKEDSFLQRYSSDPTGALTE - 18669648
HTP
1.00
 PLCG1 SH2;
RASA_group SH2		 -
0.57
 --
Y 1092 IDDTFLPVPEYINQSVPKRPA EGFR 8845374
LTP
0.05
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2		 -
0.57
 --
Y 1092 IDDTFLPVPEYINQSVPKRPA - 15302935
HTP
0.05
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2		 -
0.57
 --
Y 1092 IDDTFLPVPEYINQSVPKRPA - 17081983
HTP
0.05
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2		 -
0.57
 --
Y 1092 IDDTFLPVPEYINQSVPKRPA - 18083107
HTP
0.05
 GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2		 -
0.57
 --
Y 1110 RPAGSVQNPVYHNQPLNPAPS EGFR 8845374
LTP
1.00
 GRB2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 PTB;
Src SH2;
STAT3 SH2		 -
0.80
 --
Y 1110 RPAGSVQNPVYHNQPLNPAPS - 15302935
HTP
1.00
 GRB2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 PTB;
Src SH2;
STAT3 SH2		 -
0.80
 --
Y 1125 LNPAPSRDPHYQDPHSTAVGN SRC 8845374
LTP
1.00
 PLCG1 SH2;
RASA_group SH2;
Src SH2		 -
0.86
 --
Y 1125 LNPAPSRDPHYQDPHSTAVGN SRC 11983694
LTP
1.00
 PLCG1 SH2;
RASA_group SH2;
Src SH2		 -
0.86
 --
Y 1125 LNPAPSRDPHYQDPHSTAVGN SRC 10075741
LTP
1.00
 PLCG1 SH2;
RASA_group SH2;
Src SH2		 -
0.86
 --
Y 1172 SHQISLDNPDYQQDFFPKEAK EGFR 8845374
LTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 PTB;
SHC3 PTB;
Src SH2;
VAV2 SH2		 -
0.67
 --
Y 1172 SHQISLDNPDYQQDFFPKEAK - 15302935
HTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 PTB;
SHC3 PTB;
Src SH2;
VAV2 SH2		 -
0.67
 --
Y 1172 SHQISLDNPDYQQDFFPKEAK - 17081983
HTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 PTB;
SHC3 PTB;
Src SH2;
VAV2 SH2		 -
0.67
 --
Y 1172 SHQISLDNPDYQQDFFPKEAK - 18083107
HTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 PTB;
SHC3 PTB;
Src SH2;
VAV2 SH2		 -
0.67
 --
Y 1197 FKGSTAENAEYLRVAPQSSEF EGFR 8845374
LTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2		 -
0.54
 --
Y 1197 FKGSTAENAEYLRVAPQSSEF - 15302935
HTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2		 -
0.54
 --
Y 1197 FKGSTAENAEYLRVAPQSSEF - 17081983
HTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2		 -
0.54
 --
Y 1197 FKGSTAENAEYLRVAPQSSEF - 18083107
HTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2		 -
0.54
 --

Substrate: SOCS3 (protein kinase inhibitor activity)
Seq-ID: O14543 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
MINT-63063   PIN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein kinase inhibitor activity regulation of growth,
negative regulation of signal transduction,
anti-apoptosis,
JAK-STAT cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 221 PGPIREFLDQYDAPL       - 12783885
LTP
0.99
 CRKL SH2;
NCK SH2;
RASA_group SH2		 SOCS_box
0.43
 --
Y 221 PGPIREFLDQYDAPL       Lck 15173187
LTP
0.99
 CRKL SH2;
NCK SH2;
RASA_group SH2		 SOCS_box
0.43
 --

Substrate: IGF1-R (Receptor tyrosine kinase)
Seq-ID: P08069 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-15644   GRB10_HUMAN
MINT-18053   IRS2_HUMAN
MINT-1774754   ARHGC_MOUSE
MINT-1774976   ARHGC_HUMAN
MINT-6800783   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoinositide 3-kinase binding,
identical protein binding,
insulin-like growth factor receptor activity,
insulin binding,
metal ion binding,
insulin receptor binding,
insulin receptor substrate binding,
ATP binding,
insulin-like growth factor I binding		 microsome,
integral to plasma membrane		 positive regulation of DNA replication,
positive regulation of cell proliferation,
positive regulation of cell migration,
anti-apoptosis,
phosphoinositide 3-kinase cascade,
phosphoinositide-mediated signaling,
immune response,
protein amino acid autophosphorylation,
insulin receptor signaling pathway,
protein tetramerization
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 980 GVLYASVNPEYFSAADVYVPD IGF1R 8550552
LTP
1.00
 CRK SH2;
IRS1 PTB;
RASA_group SH2;
SHC PTB		 -
0.07
 1P4O 89.96%
Y 980 GVLYASVNPEYFSAADVYVPD IGF1R 8940173
LTP
1.00
 CRK SH2;
IRS1 PTB;
RASA_group SH2;
SHC PTB		 -
0.07
 1P4O 89.96%
Y 980 GVLYASVNPEYFSAADVYVPD - 7537849
LTP
1.00
 CRK SH2;
IRS1 PTB;
RASA_group SH2;
SHC PTB		 -
0.07
 1P4O 89.96%
Y 980 GVLYASVNPEYFSAADVYVPD - 7559478
LTP
1.00
 CRK SH2;
IRS1 PTB;
RASA_group SH2;
SHC PTB		 -
0.07
 1P4O 89.96%

Substrate: CD5 (T-cell surface glycoprotein CD5 precursor (Lymphocyte glycoprotein T1/Leu-1) (Lymphocyte antigen CD5))
Seq-ID: P06127 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
scavenger receptor activity integral to plasma membrane cell recognition,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 453 NPTASHVDNEYSQPPRNSRLS - 12522270
HTP
1.00
 Lck SH2;
RASA_group SH2		 -
0.71
 - medium
Y 453 NPTASHVDNEYSQPPRNSRLS - 15144186
HTP
1.00
 Lck SH2;
RASA_group SH2		 -
0.71
 - medium
Y 453 NPTASHVDNEYSQPPRNSRLS Lck 11298344
LTP
1.00
 Lck SH2;
RASA_group SH2		 -
0.71
 - medium
Y 453 NPTASHVDNEYSQPPRNSRLS - 15659558
HTP
1.00
 Lck SH2;
RASA_group SH2		 -
0.71
 - medium

Substrate: Insulin R (Receptor tyrosine kinase)
Seq-ID: P06213 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16516   GRB10_HUMAN
MINT-16842   MD2L1_HUMAN
MINT-18199   IRS2_HUMAN
MINT-19010   IRS1_HUMAN
MINT-73466   GRB10_MOUSE
MINT-6793537   INSR_RAT
MINT-6794075   IRS1_MOUSE
MINT-6794090   INSR_MOUSE
MINT-6794946   PTN1_HUMAN
MINT-6795115   IRS1_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
insulin-like growth factor receptor binding,
insulin binding,
PTB domain binding,
GTP binding,
metal ion binding,
insulin receptor substrate binding,
ATP binding,
insulin-like growth factor I binding,
insulin receptor activity,
SH2 domain binding,
phosphoinositide 3-kinase binding,
insulin-like growth factor II binding,
receptor signaling protein tyrosine kinase activity		 microsome,
caveola,
insulin receptor complex,
endosome membrane		 positive regulation of glycolysis,
positive regulation of MAPKKK cascade,
positive regulation of developmental growth,
regulation of embryonic development,
heart morphogenesis,
positive regulation of cell migration,
carbohydrate metabolic process,
protein heterotetramerization,
positive regulation of protein kinase B signaling cascade,
protein amino acid autophosphorylation,
activation of MAPK activity,
positive regulation of glycogen biosynthetic process,
positive regulation of mitosis,
peptidyl-tyrosine phosphorylation,
positive regulation of glucose import,
positive regulation of respiratory burst,
activation of protein kinase B activity,
G-protein coupled receptor protein signaling pathway,
positive regulation of DNA replication,
positive regulation of protein amino acid phosphorylation,
positive regulation of cell proliferation,
glucose homeostasis,
positive regulation of nitric oxide biosynthetic process,
transformation of host cell by virus,
regulation of gene-specific transcription
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 999 GPLYASSNPEYLSASDVFPCS INSR 8662806
LTP
1.00
 CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2		 -
0.11
 --
Y 999 GPLYASSNPEYLSASDVFPCS INSR 1658004
LTP
1.00
 CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2		 -
0.11
 --
Y 999 GPLYASSNPEYLSASDVFPCS - 8393870
LTP
1.00
 CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2		 -
0.11
 --
Y 999 GPLYASSNPEYLSASDVFPCS INSR 10340378
LTP
1.00
 CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2		 -
0.11
 --

Substrate: Gab1 (Multisubstrate docking protein downstream in the signaling pathways of different RTK.)
Seq-ID: Q13480 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-58395   GRB2_HUMAN
MINT-58403   GRAP2_HUMAN
MINT-58404   MET_HUMAN
MINT-68564   BMX_HUMAN
MINT-1893011   P85A_HUMAN
MINT-6169406   PTN11_HUMAN
MINT-6169502   PAXI_HUMAN
MINT-7971128   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3/SH2 adaptor activity cytosol epidermal growth factor receptor signaling pathway,
insulin receptor signaling pathway,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 317 YDIPPTPGNTYQIPRTFPEGT - 16497976
HTP
0.24
 CRKL SH2;
CRK SH2;
PLCG1 SH2;
RASA_group SH2		 -
0.74
 - low

Substrate: PDGF-R beta (Beta platelet-derived growth factor receptor)
Seq-ID: P09619 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-2832596   NHRF2_HUMAN
MINT-2832984   PTEN_HUMAN
MINT-2833042   NHRF1_HUMAN
MINT-6762380   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
vascular endothelial growth factor receptor activity,
platelet-derived growth factor binding,
platelet activating factor receptor activity,
platelet-derived growth factor receptor binding,
ATP binding,
platelet-derived growth factor beta-receptor activity		 integral to plasma membrane positive regulation of cell proliferation,
positive regulation of cell migration,
protein amino acid autophosphorylation,
peptidyl-tyrosine phosphorylation,
cell chemotaxis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 579 IESVSSDGHEYIYVDPMQLPY PDGFR_beta 8195171
LTP
1.00
 Fyn SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2;
SLA SH2;
Src SH2;
STAT5 SH2;
YES1 SH2		 -
0.15
 - medium
Y 581 SVSSDGHEYIYVDPMQLPYDS PDGFR_beta 8617789
LTP
1.00
 Fyn SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2;
RASA_group SH2;
SLA SH2;
Src SH2;
STAT5 SH2;
YES1 SH2		 -
0.16
 - medium
Y 740 VSLTGESDGGYMDMSKDESVD PDGFR_beta 8195171
LTP
1.00
 Fyn SH2;
NCK SH2;
PIK3R1 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2		 TyrKc
0.45
 - medium
Y 751 MDMSKDESVDYVPMLDMKGDV PDGFR_beta 8195171
LTP
1.00
 Fyn SH2;
NCK SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2;
Src SH2		 TyrKc
0.29
 - medium
Y 751 MDMSKDESVDYVPMLDMKGDV PDGFR_group 8195171
LTP
1.00
 Fyn SH2;
NCK SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2;
Src SH2		 TyrKc
0.29
 - medium
Y 771 VKYADIESSNYMAPYDNYVPS PDGFR_beta 8195171
LTP
1.00
 CRK SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2		 TyrKc
0.25
 - medium
Y 857 LARDIMRDSNYISKGSTFLPL PDGFR_beta 10821867
LTP
1.00
 Fyn SH2;
RASA_group SH2;
Src SH2;
YES1 SH2		 TyrKc
0.08
 - medium
Y 857 LARDIMRDSNYISKGSTFLPL PDGFR_group 10821867
LTP
1.00
 Fyn SH2;
RASA_group SH2;
Src SH2;
YES1 SH2		 TyrKc
0.08
 - medium
Y 857 LARDIMRDSNYISKGSTFLPL PDGFR_beta 2550144
LTP
1.00
 Fyn SH2;
RASA_group SH2;
Src SH2;
YES1 SH2		 TyrKc
0.08
 - medium
Y 857 LARDIMRDSNYISKGSTFLPL PDGFR_group 2550144
LTP
1.00
 Fyn SH2;
RASA_group SH2;
Src SH2;
YES1 SH2		 TyrKc
0.08
 - medium

Substrate: p62DOK (Docking protein, common target of PTKs)
Seq-ID: Q99704 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-74512   ERBB2_HUMAN
MINT-7974670   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
insulin receptor binding cytosol,
perinuclear region of cytoplasm		 transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 296 QELLDSPPALYAEPLDSLRIA - 12087092
LTP
0.05
 ABL1 SH2;
CRKL SH2;
RASA_group SH2		 -
0.48
 --
Y 296 QELLDSPPALYAEPLDSLRIA - 10688886
LTP
0.05
 ABL1 SH2;
CRKL SH2;
RASA_group SH2		 -
0.48
 --
Y 315 IAPCPSQDSLYSDPLDSTSAQ - 12087092
LTP
1.00
 ABL1 SH2;
CRKL SH2;
RASA_group SH2		 -
0.66
 --
Y 315 IAPCPSQDSLYSDPLDSTSAQ - 10688886
LTP
1.00
 ABL1 SH2;
CRKL SH2;
RASA_group SH2		 -
0.66
 --
Y 315 IAPCPSQDSLYSDPLDSTSAQ - 18083107
HTP
1.00
 ABL1 SH2;
CRKL SH2;
RASA_group SH2		 -
0.66
 --
Y 362 KLTDPKEDPIYDEPEGLAPVP - 12087092
LTP
1.00
 ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2		 -
0.82
 --
Y 362 KLTDPKEDPIYDEPEGLAPVP INSR 11551902
LTP
1.00
 ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2		 -
0.82
 --
Y 362 KLTDPKEDPIYDEPEGLAPVP - 10688886
LTP
1.00
 ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2		 -
0.82
 --
Y 362 KLTDPKEDPIYDEPEGLAPVP - 15592455
HTP
1.00
 ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2		 -
0.82
 --
Y 362 KLTDPKEDPIYDEPEGLAPVP - 16094384
HTP
1.00
 ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2		 -
0.82
 --
Y 377 GLAPVPPQGLYDLPREPKDAW - 12087092
LTP
1.00
 ABL1 SH2;
CRKL SH2;
INPP5D SH2;
RASA_group SH2		 -
0.62
 --
Y 377 GLAPVPPQGLYDLPREPKDAW - 10688886
LTP
1.00
 ABL1 SH2;
CRKL SH2;
INPP5D SH2;
RASA_group SH2		 -
0.62
 --
Y 377 GLAPVPPQGLYDLPREPKDAW - 15592455
HTP
1.00
 ABL1 SH2;
CRKL SH2;
INPP5D SH2;
RASA_group SH2		 -
0.62
 --
Y 377 GLAPVPPQGLYDLPREPKDAW - 16094384
HTP
1.00
 ABL1 SH2;
CRKL SH2;
INPP5D SH2;
RASA_group SH2		 -
0.62
 --
Y 398 WCQARVKEEGYELPYNPATDD - 12087092
LTP
0.17
 ABL1 SH2;
CRKL SH2;
RASA_group SH2		 -
0.48
 --
Y 398 WCQARVKEEGYELPYNPATDD INSR 11551902
LTP
0.17
 ABL1 SH2;
CRKL SH2;
RASA_group SH2		 -
0.48
 --
Y 398 WCQARVKEEGYELPYNPATDD - 10688886
LTP
0.17
 ABL1 SH2;
CRKL SH2;
RASA_group SH2		 -
0.48
 --
Y 398 WCQARVKEEGYELPYNPATDD - 15592455
HTP
0.17
 ABL1 SH2;
CRKL SH2;
RASA_group SH2		 -
0.48
 --
Y 398 WCQARVKEEGYELPYNPATDD - 16094384
HTP
0.17
 ABL1 SH2;
CRKL SH2;
RASA_group SH2		 -
0.48
 --
Y 409 ELPYNPATDDYAVPPPRSTKP - 12087092
LTP
1.00
 ABL1 SH2;
CRKL SH2;
RASA_group SH2		 -
0.72
 --
Y 409 ELPYNPATDDYAVPPPRSTKP - 10688886
LTP
1.00
 ABL1 SH2;
CRKL SH2;
RASA_group SH2		 -
0.72
 --
Y 409 ELPYNPATDDYAVPPPRSTKP - 15592455
HTP
1.00
 ABL1 SH2;
CRKL SH2;
RASA_group SH2		 -
0.72
 --
Y 409 ELPYNPATDDYAVPPPRSTKP - 16094384
HTP
1.00
 ABL1 SH2;
CRKL SH2;
RASA_group SH2		 -
0.72
 --

Substrate: EPHB2 (Receptor for member of the ephrinB family)
Seq-ID: P54763 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-3388251   EPHA4_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transmembrane-ephrin receptor activity,
axon guidance receptor activity,
ATP binding,
receptor binding		 neuronal cell body,
integral to plasma membrane,
synapse		 negative regulation of axonogenesis,
retinal ganglion cell axon guidance,
positive regulation of long-term neuronal synaptic plasticity,
ephrin receptor signaling pathway,
learning,
camera-type eye morphogenesis,
central nervous system projection neuron axonogenesis,
peptidyl-tyrosine phosphorylation,
optic nerve morphogenesis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 604 SGHMTPGMKIYIDPFTYEDPN EphB2 10572014
LTP
1.00
 RASA_group SH2;
SH2D3C SH2		 -
0.30
 1JPA 15.60%
Y 604 SGHMTPGMKIYIDPFTYEDPN - 10542222
LTP
1.00
 RASA_group SH2;
SH2D3C SH2		 -
0.30
 1JPA 15.60%
Y 604 SGHMTPGMKIYIDPFTYEDPN - 9233798
LTP
1.00
 RASA_group SH2;
SH2D3C SH2		 -
0.30
 1JPA 15.60%
Y 610 GMKIYIDPFTYEDPNEAVREF EphB2 8622893
LTP
1.00
 Fyn SH2;
RASA_group SH2;
Src SH2		 -
0.22
 1JPA 19.72%
Y 610 GMKIYIDPFTYEDPNEAVREF EphB2 10572014
LTP
1.00
 Fyn SH2;
RASA_group SH2;
Src SH2		 -
0.22
 1JPA 19.72%
Y 610 GMKIYIDPFTYEDPNEAVREF - 9233798
LTP
1.00
 Fyn SH2;
RASA_group SH2;
Src SH2		 -
0.22
 1JPA 19.72%
Y 610 GMKIYIDPFTYEDPNEAVREF EphB2 9632142
LTP
1.00
 Fyn SH2;
RASA_group SH2;
Src SH2		 -
0.22
 1JPA 19.72%

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