List of substrates found:

EPHB3  p56(dok-2)  EGFR  SOCS3  IGF1-R  CD5  Insulin R  Gab1  PDGF-R beta  p62DOK  EPHB2 


Substrate: EPHB3 (Receptor for member of the ephrinB family)
Seq-ID: P54753 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 614 GMKVYIDPFTYEDPNEAVREF EphB3 9674711
LTP
1.00
CRK SH2;
Fyn SH2;
RASA_group SH2
-
0.26
- low

Substrate: p56(dok-2) (Adapter molecule)
Seq-ID: O60496 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
identical protein binding,
insulin receptor binding
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 271 PASLPRPDSPYSRPHDSLPPP - 10508618
LTP
0.07
RASA_group SH2 -
0.84
- medium
Y 299 APRPRGQEGEYAVPFDAVARS - 10508618
LTP
1.00
RASA_group SH2 -
0.65
- medium
Y 299 APRPRGQEGEYAVPFDAVARS - 12522270
HTP
1.00
RASA_group SH2 -
0.65
- medium
Y 299 APRPRGQEGEYAVPFDAVARS - 15144186
HTP
1.00
RASA_group SH2 -
0.65
- medium
Y 299 APRPRGQEGEYAVPFDAVARS - 15592455
HTP
1.00
RASA_group SH2 -
0.65
- medium
Y 299 APRPRGQEGEYAVPFDAVARS - 16094384
HTP
1.00
RASA_group SH2 -
0.65
- medium
Y 299 APRPRGQEGEYAVPFDAVARS - 18083107
HTP
1.00
RASA_group SH2 -
0.65
- medium

Substrate: EGFR (Receptor for EGF and other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor,)
Seq-ID: P00533 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1016 DMDDVVDADEYLIPQQGFFSS SRC 8845374
LTP
1.00
CRK SH2;
PLCG1 SH2;
RASA_group SH2;
Src SH2
-
0.41
1XKK 41.92%
Y 1016 DMDDVVDADEYLIPQQGFFSS - 7680558
LTP
1.00
CRK SH2;
PLCG1 SH2;
RASA_group SH2;
Src SH2
-
0.41
1XKK 41.92%
Y 1016 DMDDVVDADEYLIPQQGFFSS - 15302935
HTP
1.00
CRK SH2;
PLCG1 SH2;
RASA_group SH2;
Src SH2
-
0.41
1XKK 41.92%
Y 1069 PIKEDSFLQRYSSDPTGALTE - 15302935
HTP
1.00
PLCG1 SH2;
RASA_group SH2
-
0.57
--
Y 1069 PIKEDSFLQRYSSDPTGALTE - 17081983
HTP
1.00
PLCG1 SH2;
RASA_group SH2
-
0.57
--
Y 1069 PIKEDSFLQRYSSDPTGALTE - 18669648
HTP
1.00
PLCG1 SH2;
RASA_group SH2
-
0.57
--
Y 1092 IDDTFLPVPEYINQSVPKRPA EGFR 8845374
LTP
0.05
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2
-
0.57
--
Y 1092 IDDTFLPVPEYINQSVPKRPA - 15302935
HTP
0.05
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2
-
0.57
--
Y 1092 IDDTFLPVPEYINQSVPKRPA - 17081983
HTP
0.05
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2
-
0.57
--
Y 1092 IDDTFLPVPEYINQSVPKRPA - 18083107
HTP
0.05
GRB2 SH2;
Lck SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
STAT3 SH2
-
0.57
--
Y 1110 RPAGSVQNPVYHNQPLNPAPS EGFR 8845374
LTP
1.00
GRB2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 PTB;
Src SH2;
STAT3 SH2
-
0.80
--
Y 1110 RPAGSVQNPVYHNQPLNPAPS - 15302935
HTP
1.00
GRB2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 PTB;
Src SH2;
STAT3 SH2
-
0.80
--
Y 1125 LNPAPSRDPHYQDPHSTAVGN SRC 8845374
LTP
1.00
PLCG1 SH2;
RASA_group SH2;
Src SH2
-
0.86
--
Y 1125 LNPAPSRDPHYQDPHSTAVGN SRC 11983694
LTP
1.00
PLCG1 SH2;
RASA_group SH2;
Src SH2
-
0.86
--
Y 1125 LNPAPSRDPHYQDPHSTAVGN SRC 10075741
LTP
1.00
PLCG1 SH2;
RASA_group SH2;
Src SH2
-
0.86
--
Y 1172 SHQISLDNPDYQQDFFPKEAK EGFR 8845374
LTP
1.00
ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 PTB;
SHC3 PTB;
Src SH2;
VAV2 SH2
-
0.67
--
Y 1172 SHQISLDNPDYQQDFFPKEAK - 15302935
HTP
1.00
ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 PTB;
SHC3 PTB;
Src SH2;
VAV2 SH2
-
0.67
--
Y 1172 SHQISLDNPDYQQDFFPKEAK - 17081983
HTP
1.00
ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 PTB;
SHC3 PTB;
Src SH2;
VAV2 SH2
-
0.67
--
Y 1172 SHQISLDNPDYQQDFFPKEAK - 18083107
HTP
1.00
ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 PTB;
SHC3 PTB;
Src SH2;
VAV2 SH2
-
0.67
--
Y 1197 FKGSTAENAEYLRVAPQSSEF EGFR 8845374
LTP
1.00
ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2
-
0.54
--
Y 1197 FKGSTAENAEYLRVAPQSSEF - 15302935
HTP
1.00
ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2
-
0.54
--
Y 1197 FKGSTAENAEYLRVAPQSSEF - 17081983
HTP
1.00
ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2
-
0.54
--
Y 1197 FKGSTAENAEYLRVAPQSSEF - 18083107
HTP
1.00
ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2
-
0.54
--

Substrate: SOCS3 (protein kinase inhibitor activity)
Seq-ID: O14543 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 221 PGPIREFLDQYDAPL       - 12783885
LTP
0.99
CRKL SH2;
NCK SH2;
RASA_group SH2
SOCS_box
0.43
--
Y 221 PGPIREFLDQYDAPL       Lck 15173187
LTP
0.99
CRKL SH2;
NCK SH2;
RASA_group SH2
SOCS_box
0.43
--

Substrate: IGF1-R (Receptor tyrosine kinase)
Seq-ID: P08069 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 980 GVLYASVNPEYFSAADVYVPD IGF1R 8550552
LTP
1.00
CRK SH2;
IRS1 PTB;
RASA_group SH2;
SHC PTB
-
0.07
1P4O 89.96%
Y 980 GVLYASVNPEYFSAADVYVPD IGF1R 8940173
LTP
1.00
CRK SH2;
IRS1 PTB;
RASA_group SH2;
SHC PTB
-
0.07
1P4O 89.96%
Y 980 GVLYASVNPEYFSAADVYVPD - 7537849
LTP
1.00
CRK SH2;
IRS1 PTB;
RASA_group SH2;
SHC PTB
-
0.07
1P4O 89.96%
Y 980 GVLYASVNPEYFSAADVYVPD - 7559478
LTP
1.00
CRK SH2;
IRS1 PTB;
RASA_group SH2;
SHC PTB
-
0.07
1P4O 89.96%

Substrate: CD5 (T-cell surface glycoprotein CD5 precursor (Lymphocyte glycoprotein T1/Leu-1) (Lymphocyte antigen CD5))
Seq-ID: P06127 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
scavenger receptor activity integral to plasma membrane cell recognition,
cell proliferation
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 453 NPTASHVDNEYSQPPRNSRLS - 12522270
HTP
1.00
Lck SH2;
RASA_group SH2
-
0.71
- medium
Y 453 NPTASHVDNEYSQPPRNSRLS - 15144186
HTP
1.00
Lck SH2;
RASA_group SH2
-
0.71
- medium
Y 453 NPTASHVDNEYSQPPRNSRLS Lck 11298344
LTP
1.00
Lck SH2;
RASA_group SH2
-
0.71
- medium
Y 453 NPTASHVDNEYSQPPRNSRLS - 15659558
HTP
1.00
Lck SH2;
RASA_group SH2
-
0.71
- medium

Substrate: Insulin R (Receptor tyrosine kinase)
Seq-ID: P06213 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 999 GPLYASSNPEYLSASDVFPCS INSR 8662806
LTP
1.00
CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2
-
0.11
--
Y 999 GPLYASSNPEYLSASDVFPCS INSR 1658004
LTP
1.00
CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2
-
0.11
--
Y 999 GPLYASSNPEYLSASDVFPCS - 8393870
LTP
1.00
CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2
-
0.11
--
Y 999 GPLYASSNPEYLSASDVFPCS INSR 10340378
LTP
1.00
CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2
-
0.11
--

Substrate: Gab1 (Multisubstrate docking protein downstream in the signaling pathways of different RTK.)
Seq-ID: Q13480 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 317 YDIPPTPGNTYQIPRTFPEGT - 16497976
HTP
0.24
CRKL SH2;
CRK SH2;
PLCG1 SH2;
RASA_group SH2
-
0.74
- low

Substrate: PDGF-R beta (Beta platelet-derived growth factor receptor)
Seq-ID: P09619 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 579 IESVSSDGHEYIYVDPMQLPY PDGFR_beta 8195171
LTP
1.00
Fyn SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2;
SLA SH2;
Src SH2;
STAT5 SH2;
YES1 SH2
-
0.15
- medium
Y 581 SVSSDGHEYIYVDPMQLPYDS PDGFR_beta 8617789
LTP
1.00
Fyn SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2;
RASA_group SH2;
SLA SH2;
Src SH2;
STAT5 SH2;
YES1 SH2
-
0.16
- medium
Y 740 VSLTGESDGGYMDMSKDESVD PDGFR_beta 8195171
LTP
1.00
Fyn SH2;
NCK SH2;
PIK3R1 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2
TyrKc
0.45
- medium
Y 751 MDMSKDESVDYVPMLDMKGDV PDGFR_beta 8195171
LTP
1.00
Fyn SH2;
NCK SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2;
Src SH2
TyrKc
0.29
- medium
Y 751 MDMSKDESVDYVPMLDMKGDV PDGFR_group 8195171
LTP
1.00
Fyn SH2;
NCK SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2;
Src SH2
TyrKc
0.29
- medium
Y 771 VKYADIESSNYMAPYDNYVPS PDGFR_beta 8195171
LTP
1.00
CRK SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2
TyrKc
0.25
- medium
Y 857 LARDIMRDSNYISKGSTFLPL PDGFR_beta 10821867
LTP
1.00
Fyn SH2;
RASA_group SH2;
Src SH2;
YES1 SH2
TyrKc
0.08
- medium
Y 857 LARDIMRDSNYISKGSTFLPL PDGFR_group 10821867
LTP
1.00
Fyn SH2;
RASA_group SH2;
Src SH2;
YES1 SH2
TyrKc
0.08
- medium
Y 857 LARDIMRDSNYISKGSTFLPL PDGFR_beta 2550144
LTP
1.00
Fyn SH2;
RASA_group SH2;
Src SH2;
YES1 SH2
TyrKc
0.08
- medium
Y 857 LARDIMRDSNYISKGSTFLPL PDGFR_group 2550144
LTP
1.00
Fyn SH2;
RASA_group SH2;
Src SH2;
YES1 SH2
TyrKc
0.08
- medium

Substrate: p62DOK (Docking protein, common target of PTKs)
Seq-ID: Q99704 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Try the unsigned version of the java plugin if the first link does not work for you...
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Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 296 QELLDSPPALYAEPLDSLRIA - 12087092
LTP
0.05
ABL1 SH2;
CRKL SH2;
RASA_group SH2
-
0.48
--
Y 296 QELLDSPPALYAEPLDSLRIA - 10688886
LTP
0.05
ABL1 SH2;
CRKL SH2;
RASA_group SH2
-
0.48
--
Y 315 IAPCPSQDSLYSDPLDSTSAQ - 12087092
LTP
1.00
ABL1 SH2;
CRKL SH2;
RASA_group SH2
-
0.66
--
Y 315 IAPCPSQDSLYSDPLDSTSAQ - 10688886
LTP
1.00
ABL1 SH2;
CRKL SH2;
RASA_group SH2
-
0.66
--
Y 315 IAPCPSQDSLYSDPLDSTSAQ - 18083107
HTP
1.00
ABL1 SH2;
CRKL SH2;
RASA_group SH2
-
0.66
--
Y 362 KLTDPKEDPIYDEPEGLAPVP - 12087092
LTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2
-
0.82
--
Y 362 KLTDPKEDPIYDEPEGLAPVP INSR 11551902
LTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2
-
0.82
--
Y 362 KLTDPKEDPIYDEPEGLAPVP - 10688886
LTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2
-
0.82
--
Y 362 KLTDPKEDPIYDEPEGLAPVP - 15592455
HTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2
-
0.82
--
Y 362 KLTDPKEDPIYDEPEGLAPVP - 16094384
HTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
NCK SH2;
RASA_group SH2
-
0.82
--
Y 377 GLAPVPPQGLYDLPREPKDAW - 12087092
LTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
RASA_group SH2
-
0.62
--
Y 377 GLAPVPPQGLYDLPREPKDAW - 10688886
LTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
RASA_group SH2
-
0.62
--
Y 377 GLAPVPPQGLYDLPREPKDAW - 15592455
HTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
RASA_group SH2
-
0.62
--
Y 377 GLAPVPPQGLYDLPREPKDAW - 16094384
HTP
1.00
ABL1 SH2;
CRKL SH2;
INPP5D SH2;
RASA_group SH2
-
0.62
--
Y 398 WCQARVKEEGYELPYNPATDD - 12087092
LTP
0.17
ABL1 SH2;
CRKL SH2;
RASA_group SH2
-
0.48
--
Y 398 WCQARVKEEGYELPYNPATDD INSR 11551902
LTP
0.17
ABL1 SH2;
CRKL SH2;
RASA_group SH2
-
0.48
--
Y 398 WCQARVKEEGYELPYNPATDD - 10688886
LTP
0.17
ABL1 SH2;
CRKL SH2;
RASA_group SH2
-
0.48
--
Y 398 WCQARVKEEGYELPYNPATDD - 15592455
HTP
0.17
ABL1 SH2;
CRKL SH2;
RASA_group SH2
-
0.48
--
Y 398 WCQARVKEEGYELPYNPATDD - 16094384
HTP
0.17
ABL1 SH2;
CRKL SH2;
RASA_group SH2
-
0.48
--
Y 409 ELPYNPATDDYAVPPPRSTKP - 12087092
LTP
1.00
ABL1 SH2;
CRKL SH2;
RASA_group SH2
-
0.72
--
Y 409 ELPYNPATDDYAVPPPRSTKP - 10688886
LTP
1.00
ABL1 SH2;
CRKL SH2;
RASA_group SH2
-
0.72
--
Y 409 ELPYNPATDDYAVPPPRSTKP - 15592455
HTP
1.00
ABL1 SH2;
CRKL SH2;
RASA_group SH2
-
0.72
--
Y 409 ELPYNPATDDYAVPPPRSTKP - 16094384
HTP
1.00
ABL1 SH2;
CRKL SH2;
RASA_group SH2
-
0.72
--

Substrate: EPHB2 (Receptor for member of the ephrinB family)
Seq-ID: P54763 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 604 SGHMTPGMKIYIDPFTYEDPN EphB2 10572014
LTP
1.00
RASA_group SH2;
SH2D3C SH2
-
0.30
1JPA 15.60%
Y 604 SGHMTPGMKIYIDPFTYEDPN - 10542222
LTP
1.00
RASA_group SH2;
SH2D3C SH2
-
0.30
1JPA 15.60%
Y 604 SGHMTPGMKIYIDPFTYEDPN - 9233798
LTP
1.00
RASA_group SH2;
SH2D3C SH2
-
0.30
1JPA 15.60%
Y 610 GMKIYIDPFTYEDPNEAVREF EphB2 8622893
LTP
1.00
Fyn SH2;
RASA_group SH2;
Src SH2
-
0.22
1JPA 19.72%
Y 610 GMKIYIDPFTYEDPNEAVREF EphB2 10572014
LTP
1.00
Fyn SH2;
RASA_group SH2;
Src SH2
-
0.22
1JPA 19.72%
Y 610 GMKIYIDPFTYEDPNEAVREF - 9233798
LTP
1.00
Fyn SH2;
RASA_group SH2;
Src SH2
-
0.22
1JPA 19.72%
Y 610 GMKIYIDPFTYEDPNEAVREF EphB2 9632142
LTP
1.00
Fyn SH2;
RASA_group SH2;
Src SH2
-
0.22
1JPA 19.72%


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