List of substrates found:

CD91  ErbB3  EGFR  Integrin beta 3  TRKA  Insulin R  RET  Common beta c subunit  Inositol polyphosphate 5-phosphatase 


Substrate: CD91 (Cell surface receptor)
Seq-ID: Q07954 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor activity,
calcium ion binding,
lipid transporter activity,
lipoprotein binding,
lipoprotein receptor binding,
apolipoprotein binding,
protein complex binding		 membrane fraction,
integral to plasma membrane,
coated pit,
nucleus		 lipid metabolic process,
regulation of phospholipase A2 activity,
negative regulation of Wnt receptor signaling pathway,
positive regulation of cholesterol efflux,
apoptotic cell clearance,
multicellular organismal development,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 4507 DKPTNFTNPVYATLYMGGHGS SRC 12789267
LTP
1.00
 DAB1 PTB;
GULP1 PTB;
SHC1 PTB		 -
0.41
 - low

Substrate: ErbB3 (Receptor tyrosine kinase)
Seq-ID: P21860 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-61514   CSK_HUMAN
MINT-61518   GRB2_HUMAN
MINT-61520   P85B_HUMAN
MINT-74430   ABL1_HUMAN
MINT-74454   ABL2_HUMAN
MINT-74500   CRK_HUMAN
MINT-74505   CRKL_HUMAN
MINT-74509   DAB1_HUMAN
MINT-74510   DAPP1_HUMAN
MINT-74534   FER_HUMAN
MINT-74539   FGFR1_HUMAN
MINT-74548   GRB7_HUMAN
MINT-74550   HCK_HUMAN
MINT-74559   ITK_HUMAN
MINT-74563   JAK2_HUMAN
MINT-74564   JAK3_HUMAN
MINT-74569   SH2B3_HUMAN
MINT-74588   NCK1_HUMAN
MINT-74592   NCK2_HUMAN
MINT-74617   P85A_HUMAN
MINT-74672   P55G_HUMAN
MINT-74682   PLCG1_HUMAN
MINT-74688   PTK6_HUMAN
MINT-74708   RASA1_HUMAN
MINT-74714   RIN1_HUMAN
MINT-74738   SHC1_HUMAN
MINT-74753   SRC_HUMAN
MINT-74775   KSYK_HUMAN
MINT-74784   TENC1_HUMAN
MINT-74788   TENS3_HUMAN
MINT-74795   TXK_HUMAN
MINT-74803   VAV2_HUMAN
MINT-74806   ZAP70_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein heterodimerization activity,
transmembrane receptor protein tyrosine kinase activity,
receptor signaling protein tyrosine kinase activity,
protein homodimerization activity,
protein tyrosine kinase activator activity,
ATP binding,
growth factor binding		 receptor complex,
basolateral plasma membrane,
integral to plasma membrane,
extracellular space		 protein amino acid phosphorylation,
positive regulation of phosphoinositide 3-kinase cascade,
negative regulation of signal transduction,
phosphoinositide 3-kinase cascade,
heart development,
negative regulation of secretion,
neuron apoptosis,
negative regulation of neuron apoptosis,
regulation of cell proliferation,
negative regulation of cell adhesion,
transmembrane receptor protein tyrosine kinase signaling pathway,
cranial nerve development,
wound healing,
Schwann cell differentiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1328 ATDSAFDNPDYWHSRLFPKAN - 9694850
LTP
1.00
 SHC1 PTB;
SHC_group SH2		 -
0.50
 - medium

Substrate: EGFR (Receptor for EGF and other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor,)
Seq-ID: P00533 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16802   GRB10_HUMAN
MINT-50935   1433Z_HUMAN
MINT-51101   ANXA1_HUMAN
MINT-51490   ARBK1_HUMAN
MINT-60973   CBL_HUMAN
MINT-61486   CRKL_HUMAN
MINT-61487   CSK_HUMAN
MINT-61490   STA5B_HUMAN
MINT-61540   GRB2_HUMAN
MINT-68514   PDC6I_HUMAN
MINT-74427   ABL1_HUMAN
MINT-74438   ABL2_HUMAN
MINT-74460   ANS1A_HUMAN
MINT-74469   APBB1_HUMAN
MINT-74479   DP13A_HUMAN
MINT-74487   BMX_HUMAN
MINT-74497   CRK_HUMAN
MINT-74535   FES_HUMAN
MINT-74551   IRS1_HUMAN
MINT-74555   IRS4_HUMAN
MINT-74562   JAK2_HUMAN
MINT-74566   SH2B3_HUMAN
MINT-74572   JIP1_HUMAN
MINT-74587   NCK1_HUMAN
MINT-74593   NUMB_HUMAN
MINT-74594   NUMBL_HUMAN
MINT-74606   P85A_HUMAN
MINT-74630   P85B_HUMAN
MINT-74659   P55G_HUMAN
MINT-74678   PLCG1_HUMAN
MINT-74685   PLCG2_HUMAN
MINT-74687   PTK6_HUMAN
MINT-74689   PTN11_HUMAN
MINT-74711   RASA1_HUMAN
MINT-74717   SH2B1_HUMAN
MINT-74720   SH22A_HUMAN
MINT-74732   SHC1_HUMAN
MINT-74746   SLAP1_HUMAN
MINT-74763   KSYK_HUMAN
MINT-74790   TLN1_HUMAN
MINT-74807   ZAP70_HUMAN
MINT-1788719   ERBB2_HUMAN
MINT-6169667   ESR1_HUMAN
MINT-6170031   SOS1_MOUSE
MINT-6170198   SH3G2_HUMAN
MINT-6170268   SH3K1_HUMAN
MINT-6793358   PTN1_HUMAN
MINT-7980526   TM1L1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
epidermal growth factor receptor activity,
protein heterodimerization activity,
identical protein binding,
receptor signaling protein tyrosine kinase activity,
double-stranded DNA binding,
ATP binding,
protein phosphatase binding,
actin filament binding,
MAP/ERK kinase kinase activity		 Shc-EGFR complex,
endosome,
basolateral plasma membrane,
integral to membrane,
extracellular space,
nucleus		 activation of phospholipase C activity,
protein insertion into membrane,
response to UV-A,
positive regulation of nitric oxide biosynthetic process,
positive regulation of cell migration,
positive regulation of cyclin-dependent protein kinase activity involved in G1/S,
positive regulation of catenin protein nuclear translocation,
regulation of nitric-oxide synthase activity,
positive regulation of protein kinase B signaling cascade,
ossification,
positive regulation of epithelial cell proliferation,
activation of phospholipase A2 activity by calcium-mediated signaling,
cell-cell adhesion,
regulation of peptidyl-tyrosine phosphorylation,
positive regulation of phosphorylation,
positive regulation of MAP kinase activity,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1110 RPAGSVQNPVYHNQPLNPAPS EGFR 8845374
LTP
1.00
 GRB2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 PTB;
Src SH2;
STAT3 SH2		 -
0.80
 --
Y 1110 RPAGSVQNPVYHNQPLNPAPS - 15302935
HTP
1.00
 GRB2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 PTB;
Src SH2;
STAT3 SH2		 -
0.80
 --
Y 1172 SHQISLDNPDYQQDFFPKEAK EGFR 8845374
LTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 PTB;
SHC3 PTB;
Src SH2;
VAV2 SH2		 -
0.67
 --
Y 1172 SHQISLDNPDYQQDFFPKEAK - 15302935
HTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 PTB;
SHC3 PTB;
Src SH2;
VAV2 SH2		 -
0.67
 --
Y 1172 SHQISLDNPDYQQDFFPKEAK - 17081983
HTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 PTB;
SHC3 PTB;
Src SH2;
VAV2 SH2		 -
0.67
 --
Y 1172 SHQISLDNPDYQQDFFPKEAK - 18083107
HTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 PTB;
SHC3 PTB;
Src SH2;
VAV2 SH2		 -
0.67
 --

Substrate: Integrin beta 3 (Platelet membrane glycoprotein IIIa)
Seq-ID: P05106 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-25081   ITAV_HUMAN
MINT-45900   EPS8_HUMAN
MINT-45905   RBGP1_HUMAN
MINT-45913   GULP1_HUMAN
MINT-45916   RGS12_HUMAN
MINT-45923   DAB1_MOUSE
MINT-45928   DAB2_MOUSE
MINT-45939   IRS1_RAT
MINT-45952   TLN1_MOUSE
MINT-45957   JIP1_HUMAN
MINT-45960   LIN10_CAEEL
MINT-61480   TENC1_HUMAN
MINT-61568   DOK1_MOUSE
MINT-61569   NUMB_MOUSE
MINT-1795026   TLN1_HUMAN
MINT-6794817   PTN1_HUMAN
MINT-7384376   SRC_MOUSE
MINT-7384444   LYN_HUMAN
MINT-7384460   YES_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor activity,
vascular endothelial growth factor receptor 2 binding,
identical protein binding,
platelet-derived growth factor receptor binding,
cell adhesion molecule binding		 integrin complex,
alphav-beta3 integrin-vitronectin complex,
platelet alpha granule membrane		 positive regulation of peptidyl-tyrosine phosphorylation,
positive regulation of endothelial cell proliferation,
regulation of bone resorption,
blood coagulation,
negative regulation of lipid transport,
tube development,
activation of protein kinase activity,
integrin-mediated signaling pathway,
positive regulation of vascular endothelial growth factor receptor signaling pathway,
negative regulation of lipid storage,
negative regulation of macrophage derived foam cell differentiation,
cell-matrix adhesion,
interspecies interaction between organisms,
smooth muscle cell migration,
negative regulation of lipoprotein metabolic process,
angiogenesis involved in wound healing,
positive regulation of endothelial cell migration,
negative regulation of low-density lipoprotein receptor biosynthetic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 773 AKWDTANNPLYKEATSTFTNI - 8631894
LTP
1.00
 GRB2 SH2;
PTPN11 SH2;
SHC1 PTB;
TLN1 PTB		 Integrin_b_cyt
0.26
 --
Y 773 AKWDTANNPLYKEATSTFTNI SRC 15699036
LTP
1.00
 GRB2 SH2;
PTPN11 SH2;
SHC1 PTB;
TLN1 PTB		 Integrin_b_cyt
0.26
 --
Y 773 AKWDTANNPLYKEATSTFTNI - 18088087
HTP
1.00
 GRB2 SH2;
PTPN11 SH2;
SHC1 PTB;
TLN1 PTB		 Integrin_b_cyt
0.26
 --
Y 773 AKWDTANNPLYKEATSTFTNI SRC 18398066
LTP
1.00
 GRB2 SH2;
PTPN11 SH2;
SHC1 PTB;
TLN1 PTB		 Integrin_b_cyt
0.26
 --
Y 785 EATSTFTNITYRGT        SYK 8631894
LTP
0.98
 PTPN11 SH2;
SHC1 PTB;
SYK SH2		 Integrin_b_cyt
0.26
 --
Y 785 EATSTFTNITYRGT        SRC 8631894
LTP
0.98
 PTPN11 SH2;
SHC1 PTB;
SYK SH2		 Integrin_b_cyt
0.26
 --
Y 785 EATSTFTNITYRGT        - 18088087
HTP
0.98
 PTPN11 SH2;
SHC1 PTB;
SYK SH2		 Integrin_b_cyt
0.26
 --

Substrate: TRKA (Required for high affinity binding to nerve growth factor , neurotrophin-3 and neurotrophin-4/5r.)
Seq-ID: P04629 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
MINT-6793941   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transmembrane receptor protein tyrosine kinase activity,
neurotrophin receptor activity,
ATP binding		 endosome,
integral to plasma membrane		 activation of adenylate cyclase activity,
Ras protein signal transduction,
transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 496 LQGHIIENPQYFSDACVHHIK TRKA 11159935
LTP
1.00
 FRS2 PTB;
GRB2 SH2;
PLCG1 SH2;
SHC1 PTB;
SHC1 SH2		 -
0.16
 - medium
Y 496 LQGHIIENPQYFSDACVHHIK TRKA 8155326
LTP
1.00
 FRS2 PTB;
GRB2 SH2;
PLCG1 SH2;
SHC1 PTB;
SHC1 SH2		 -
0.16
 - medium

Substrate: Insulin R (Receptor tyrosine kinase)
Seq-ID: P06213 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16516   GRB10_HUMAN
MINT-16842   MD2L1_HUMAN
MINT-18199   IRS2_HUMAN
MINT-19010   IRS1_HUMAN
MINT-73466   GRB10_MOUSE
MINT-6793537   INSR_RAT
MINT-6794075   IRS1_MOUSE
MINT-6794090   INSR_MOUSE
MINT-6794946   PTN1_HUMAN
MINT-6795115   IRS1_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
insulin-like growth factor receptor binding,
insulin binding,
PTB domain binding,
GTP binding,
metal ion binding,
insulin receptor substrate binding,
ATP binding,
insulin-like growth factor I binding,
insulin receptor activity,
SH2 domain binding,
phosphoinositide 3-kinase binding,
insulin-like growth factor II binding,
receptor signaling protein tyrosine kinase activity		 microsome,
caveola,
insulin receptor complex,
endosome membrane		 positive regulation of glycolysis,
positive regulation of MAPKKK cascade,
positive regulation of developmental growth,
regulation of embryonic development,
heart morphogenesis,
positive regulation of cell migration,
carbohydrate metabolic process,
protein heterotetramerization,
positive regulation of protein kinase B signaling cascade,
protein amino acid autophosphorylation,
activation of MAPK activity,
positive regulation of glycogen biosynthetic process,
positive regulation of mitosis,
peptidyl-tyrosine phosphorylation,
positive regulation of glucose import,
positive regulation of respiratory burst,
activation of protein kinase B activity,
G-protein coupled receptor protein signaling pathway,
positive regulation of DNA replication,
positive regulation of protein amino acid phosphorylation,
positive regulation of cell proliferation,
glucose homeostasis,
positive regulation of nitric oxide biosynthetic process,
transformation of host cell by virus,
regulation of gene-specific transcription
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 999 GPLYASSNPEYLSASDVFPCS INSR 8662806
LTP
1.00
 CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2		 -
0.11
 --
Y 999 GPLYASSNPEYLSASDVFPCS INSR 1658004
LTP
1.00
 CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2		 -
0.11
 --
Y 999 GPLYASSNPEYLSASDVFPCS - 8393870
LTP
1.00
 CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2		 -
0.11
 --
Y 999 GPLYASSNPEYLSASDVFPCS INSR 10340378
LTP
1.00
 CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2		 -
0.11
 --

Substrate: RET (Probable receptor with tyrosine-protein kinase activity; important for development.)
Seq-ID: P07949 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-60970   CBL_HUMAN
MINT-60975   GRB2_HUMAN
MINT-60981   SHC1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
calcium ion binding,
transmembrane receptor protein tyrosine kinase activity,
ATP binding		 integral to membrane protein amino acid phosphorylation,
posterior midgut development,
homophilic cell adhesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1062 LPSTWIENKLYGMSDPNWPGE - 11470823
LTP
0.19
 FRS2 PTB;
IRS1 PTB;
PIK3R1 SH2;
SHC1 PTB;
SHC1 SH2;
SHC3 PTB;
SHC3 SH2		 -
0.43
 --
Y 1062 LPSTWIENKLYGMSDPNWPGE RET 14711813
LTP
0.19
 FRS2 PTB;
IRS1 PTB;
PIK3R1 SH2;
SHC1 PTB;
SHC1 SH2;
SHC3 PTB;
SHC3 SH2		 -
0.43
 --
Y 1062 LPSTWIENKLYGMSDPNWPGE RET 14981541
LTP
0.19
 FRS2 PTB;
IRS1 PTB;
PIK3R1 SH2;
SHC1 PTB;
SHC1 SH2;
SHC3 PTB;
SHC3 SH2		 -
0.43
 --

Substrate: Common beta c subunit (Cytokine recpetor common beta chain)
Seq-ID: P26955 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cytokine receptor activity integral to membrane
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 595 QLPSFDFNGPYLGPPQSHSLP SRC 16437163
LTP
1.00
 SHC1 PTB -
0.75
 - medium

Substrate: Common beta c subunit (Cytokine recpetor common beta chain)
Seq-ID: P32927 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cytokine receptor activity granulocyte macrophage colony-stimulating factor receptor complex respiratory gaseous exchange
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 593 QASSFDFNGPYLGPPHSRSLP - 9257712
LTP
1.00
 PTPN11 SH2;
SHC1 PTB;
SHC_group SH2		 -
0.76
 - medium
Y 593 QASSFDFNGPYLGPPHSRSLP - 10362354
LTP
1.00
 PTPN11 SH2;
SHC1 PTB;
SHC_group SH2		 -
0.76
 - medium

Substrate: Inositol polyphosphate 5-phosphatase (Lipid phosphatase)
Seq-ID: O15357 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
MINT-58385   GAB1_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
actin binding,
SH3 domain binding,
SH2 domain binding		 cytosol,
actin cortical patch		 actin filament organization,
endocytosis,
cell adhesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 986 PPKNSFNNPAYYVLEGVPHQL SRC 12235291
LTP
1.00
 SHC1 PTB -
0.67
 --
Y 986 PPKNSFNNPAYYVLEGVPHQL - 12522270
HTP
1.00
 SHC1 PTB -
0.67
 --
Y 986 PPKNSFNNPAYYVLEGVPHQL - 15592455
HTP
1.00
 SHC1 PTB -
0.67
 --
Y 986 PPKNSFNNPAYYVLEGVPHQL - 17081983
HTP
1.00
 SHC1 PTB -
0.67
 --
Y 986 PPKNSFNNPAYYVLEGVPHQL - 18083107
HTP
1.00
 SHC1 PTB -
0.67
 --
Y 986 PPKNSFNNPAYYVLEGVPHQL - 18669648
HTP
1.00
 SHC1 PTB -
0.67
 --

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