Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

Achaete-scute homolog 1
Alpha-synuclein
ATP-binding cassette 1
BAD
Bcr
Beta-arrestin 2
BID
BIK
c-Jun
c-Myb
CD45
CD5
cdc25B
Cell division control protein 2
CHOP
Coagulation factor V
Complement C1r subcomponent
DNA topoisomerase II, alpha
E-cadherin
E2-CDC34
eIF-5
ERCC3
FAS-associated factor 1
GMF-beta
Histone deacetylase 1
Histone deacetylase 2
hnRPA1
HSF 1
HSP 90-alpha
HSP 90-beta
HSP-E7I
Hsp90 co-chaperone Cdc37
Hypothetical protein FLJ20419.
IFI 16
IGF2R
IKB-alpha
Lupus La protein
Max protein
Mitogen-activated protein kinase 9
Myocyte-specific enhancer factor 2A
Myocyte-specific enhancer factor 2C
n-myc
p65
PIP5K2A
PKB-alpha
PKD2
PP2C-alpha
Presenilin 2
Progesterone receptor
PTEN
RING-box protein 2
RNA binding protein S1
S-protein
SPI1
SRF
SRPK1
Stanniocalcin 2
Stress-induced-phosphoprotein 1
Structure specific recognition protein 1
TCF4
Telomerase-binding protein p23
TFPI
Thyroid hormone receptor alpha
TLE1
vitamin D receptor
WASP
XRCC1

Substrate:

Achaete-scute homolog 1 (Involved in neuron development)

Seq-ID:

Q02067 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding transcription factor activity	neuronal cell body, nucleus	central nervous system neuron development, spinal cord oligodendrocyte cell fate specification, transcription, stomach neuroendocrine cell differentiation, positive regulation of neurogenesis, positive regulation of neuron apoptosis, carotid body glomus cell differentiation, neuron fate specification, oligodendrocyte development, adrenal chromaffin cell differentiation, olfactory pit development, Notch signaling pathway, regulation of timing of subpallium neuron differentiation, neuron migration, positive regulation of Notch signaling pathway, lung neuroendocrine cell differentiation, pattern specification process, positive regulation of transcription from RNA polymerase II promoter, spinal cord association neuron differentiation, neuroblast proliferation, cerebral cortex development, neuroblast fate determination, subpallium neuron fate commitment

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	150	VPNGAANKKMSKVETLRSAVQ	CK2_alpha	15318167	LTP	1.00	MOD_CK2_1	-	HLH	0.57	-	low

Substrate:

Alpha-synuclein (Chaperone)

Seq-ID:

P37840 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-2515544   VIME_HUMAN
MINT-3387974   TPPP_HUMAN
MINT-7555062   HSP71_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
histone binding, ferrous iron binding, phospholipase binding, caspase inhibitor activity, dynein binding, alpha-tubulin binding, zinc ion binding, Hsp70 protein binding, kinesin binding, magnesium ion binding, calcium ion binding, tau protein binding	plasma membrane, cytosol, nucleus, axon, actin cytoskeleton, cell cortex, growth cone, fibril	response to magnesium ion, positive regulation of release of sequestered calcium ion into cytosol, response to interferon-gamma, regulation of phospholipase activity, negative regulation of platelet-derived growth factor receptor signaling pathway, positive regulation of inositol phosphate biosynthetic process, response to interleukin-1, response to iron(II) ion, synaptic vesicle endocytosis, negative regulation of monooxygenase activity, positive regulation of receptor recycling, response to lipopolysaccharide, negative regulation of norepinephrine uptake, negative regulation of exocytosis, negative regulation of histone acetylation, negative regulation of serotonin uptake, receptor internalization, cell death, negative regulation of dopamine uptake, negative regulation of transporter activity, negative regulation of thrombin receptor signaling pathway, positive regulation of endocytosis, anti-apoptosis, negative regulation of caspase activity

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	129	DPDNEAYEMPSEEGYQDYEPE	CK2_alpha	10617630	LTP	0.09		-	Synuclein	0.84	-	-

Substrate:

ATP-binding cassette 1 (Transport/cargo protein)

Seq-ID:

O95477 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-59503 SNTB2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
ATPase activity, anion transmembrane transporter activity, apolipoprotein A-I receptor activity, small GTPase binding, cholesterol binding, phospholipid binding, ATP binding, phospholipid transporter activity, syntaxin-13 binding, cholesterol transporter activity	membrane fraction, integral to plasma membrane, phagocytic vesicle, membrane raft	positive regulation of cAMP biosynthetic process, platelet dense granule organization, high-density lipoprotein particle assembly, cholesterol homeostasis, endosome transport, phospholipid homeostasis, lysosome organization, negative regulation of macrophage derived foam cell differentiation, phospholipid efflux, negative regulation of cholesterol storage, reverse cholesterol transport, Cdc42 protein signal transduction, cholesterol efflux, cholesterol metabolic process, interleukin-1 beta secretion, intracellular cholesterol transport, G-protein coupled receptor protein signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	1242	LGISSYGISETTLEEIFLKVA	CK2_alpha	15218032	LTP	1.00	MOD_CK2_1	-	-	0.22	-	medium
T	1243	GISSYGISETTLEEIFLKVAE	CK2_alpha	15218032	LTP	1.00	MOD_CK2_1	-	-	0.23	-	medium
S	1255	EEIFLKVAEESGVDAETSDGT	CK2_alpha	15218032	LTP	0.20		-	-	0.39	-	medium

Substrate:

BAD (Bcl2-antagonist of cell death (BAD) (Bcl-2 binding component 6) (Bcl- XL/Bcl-2 associated death promoter) (Bcl-2-like 8 protein))

Seq-ID:

Q61337 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	cytosol, mitochondrial outer membrane	induction of apoptosis by extracellular signals, glucose homeostasis, cytokine-mediated signaling pathway, apoptosis, positive regulation of B cell differentiation, positive regulation of T cell differentiation, glucose catabolic process, cell proliferation, regulation of caspase activity

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	117	RSRHSSYPAGTEEDEGMEEEL	CK2_alpha	15234118	LTP	0.93		-	Bcl-2_BAD	0.87	-	medium

Substrate:

Bcr (Breakpoint cluster region protein)

Seq-ID:

P11274 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-69534   AT2B1_HUMAN
MINT-69536   CLH1_HUMAN
MINT-69537   CFTR_HUMAN
MINT-69540   ZO2_HUMAN
MINT-69542   RGS12_HUMAN
MINT-4961172   AFAD_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
Rho guanyl-nucleotide exchange factor activity, protein serine/threonine kinase activity, ATP binding, GTPase activator activity	intracellular	protein amino acid phosphorylation, signal transduction, regulation of Rho protein signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1264	AIPAPDSKRQSILFSTEV	CK2_alpha	11084041	LTP	1.00		-	-	0.29	-	medium

Substrate:

Beta-arrestin 2 (Beta-arrestin 2)

Seq-ID:

P32121 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-16320   MDM2_HUMAN
MINT-61748   HIPK3_HUMAN
MINT-7263161   MK10_HUMAN
MINT-7263196   M3K5_HUMAN
MINT-7263286   MP2K4_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
ubiquitin protein ligase binding, angiotensin receptor binding	plasma membrane, cytoplasmic membrane-bounded vesicle, coated pit, nucleus	positive regulation of ERK1 and ERK2 cascade, transcription from RNA polymerase II promoter, negative regulation of NF-kappaB transcription factor activity, negative regulation of protein ubiquitination, negative regulation of signal transduction, proteasomal ubiquitin-dependent protein catabolic process, protein ubiquitination, negative regulation of natural killer cell mediated cytotoxicity, protein transport, signal transduction, sensory perception, G-protein coupled receptor internalization, transforming growth factor beta receptor signaling pathway, cell chemotaxis, desensitization of G-protein coupled receptor protein signaling pathway by arrestin

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	382	NLIEFDTNYATDDDIVFEDFA	CK2_alpha	11877451	LTP	0.01		-	-	0.18	-	medium

Substrate:

BID (Ligand)

Seq-ID:

P70444 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-15650   BCL2_MOUSE
MINT-16786   B2CL1_HUMAN
MINT-7542986   ITCH_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
ubiquitin protein ligase binding	mitochondrial membrane, cytosol	release of cytochrome c from mitochondria, positive regulation of apoptosis, regulation of mitochondrial membrane permeability, protein targeting to mitochondrion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	58	WEADLEDELQTDGSQASRSFN	CK2_alpha	11583622	LTP	1.00		-	BID	0.58	-	-

Substrate:

BIK (protein binding)

Seq-ID:

Q13323 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	integral to membrane, endomembrane system	apoptosis, induction of apoptosis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	35	PTMEVLGMTDSEEDLDPMEDF	CK2_alpha	11084041	LTP	-	MOD_CK2_1	-	-	0.61	-	medium

Substrate:

c-Jun (c-Jun (Transcription factor AP-1))

Seq-ID:

P05412 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14077   DDX21_HUMAN
MINT-68803   VE7_HPV16
MINT-68804   FOS_HUMAN
MINT-6628041   ATF2_HUMAN
MINT-6628056   CITE1_HUMAN
MINT-7148314   MK08_HUMAN
MINT-7148323   MK09_HUMAN
MINT-7148332   MK10_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription repressor activity, R-SMAD binding, RNA polymerase II transcription factor activity, enhancer binding, Rho GTPase activator activity, transcription coactivator activity, promoter binding		SMAD protein nuclear translocation, positive regulation by host of viral transcription, SMAD protein signal transduction, negative regulation of DNA binding, transforming growth factor beta receptor signaling pathway, positive regulation of transcription from RNA polymerase II promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	231	RLQALKEEPQTVPEMPGETPP	CK2_alpha	11075956	LTP	1.00	MOD_CK2_1	-	Jun	0.89	-	-

Substrate:

c-Myb (Transcription factor)

Seq-ID:

P10242 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-6802128 CLH1_HUMAN
MINT-6802201 LIN9_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
DNA binding, transcription activator activity, protein binding	nuclear matrix	transcription, regulation of transcription, DNA-dependent

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	11	MARRPRHSIYSSDEDDEDFEM	CK2_alpha	11313925	LTP	0.94	MOD_CK2_1	-	-	0.52	-	low
S	11	MARRPRHSIYSSDEDDEDFEM	CK2_alpha	7735324	LTP	0.94	MOD_CK2_1	-	-	0.52	-	low
S	12	ARRPRHSIYSSDEDDEDFEMC	CK2_alpha	11313925	LTP	1.00	MOD_CK2_1	-	-	0.51	-	low
S	12	ARRPRHSIYSSDEDDEDFEMC	CK2_alpha	7735324	LTP	1.00	MOD_CK2_1	-	-	0.51	-	low

Substrate:

CD45 (Receptor tyrosine phosphatase)

Seq-ID:

P06800 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13640 JAK1_MOUSE
MINT-17285 JAK2_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein tyrosine phosphatase activity, protein kinase binding, heparan sulfate proteoglycan binding, heparin binding	external side of plasma membrane, integral to plasma membrane, membrane raft, focal adhesion	positive regulation of MAPKKK cascade, positive thymic T cell selection, defense response to virus, negative regulation of peptidyl-tyrosine phosphorylation, protein amino acid dephosphorylation, positive regulation of antigen receptor-mediated signaling pathway, positive regulation of apoptosis, positive regulation of gamma-delta T cell differentiation, activation of MAPK activity, release of sequestered calcium ion into cytosol, negative regulation of T cell mediated cytotoxicity, positive regulation of humoral immune response mediated by circulating immunoglobulin, T cell receptor signaling pathway, regulation of B cell receptor signaling pathway, T cell proliferation, negative regulation of protein kinase activity, heterotypic cell-cell adhesion, negative regulation of protein amino acid autophosphorylation, negative thymic T cell selection, regulation of B cell differentiation, B cell proliferation, leukocyte cell-cell adhesion, negative regulation of cytokine-mediated signaling pathway, B cell differentiation, positive regulation of isotype switching to IgG isotypes, positive regulation of T cell mediated cytotoxicity, positive regulation of B cell proliferation, B cell receptor signaling pathway, regulation of cell cycle, positive regulation of alpha-beta T cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	988	LEMSKESEPESDESSDDDSDS	CK2_alpha	10066810	LTP	1.00		-	PTPc	0.91	-	low
S	991	SKESEPESDESSDDDSDSEET	CK2_alpha	10066810	LTP	1.00		-	PTPc	0.91	-	low
S	992	KESEPESDESSDDDSDSEETS	CK2_alpha	10066810	LTP	1.00		-	PTPc	0.91	-	low
S	996	PESDESSDDDSDSEETSKYIN	CK2_alpha	10066810	LTP	1.00	MOD_CK2_1	-	PTPc	0.80	-	low

Substrate:

CD45 (Receptor tyrosine phosphatase)

Seq-ID:

P08575 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein kinase binding, transmembrane receptor protein tyrosine phosphatase activity	focal adhesion, integral to plasma membrane, membrane raft	positive regulation of B cell proliferation, B cell receptor signaling pathway, regulation of S phase, immunoglobulin biosynthetic process, defense response to virus, protein amino acid dephosphorylation, positive regulation of antigen receptor-mediated signaling pathway, release of sequestered calcium ion into cytosol, negative regulation of T cell mediated cytotoxicity, T cell receptor signaling pathway, negative regulation of protein kinase activity, B cell proliferation, negative regulation of cytokine-mediated signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	999	LEMSKESEHDSDESSDDDSDS	CK2_alpha	10066810	LTP	1.00		-	PTPc	0.90	-	medium
S	1002	SKESEHDSDESSDDDSDSEEP	CK2_alpha	10066810	LTP	1.00		-	PTPc	0.92	-	medium
S	1003	KESEHDSDESSDDDSDSEEPS	CK2_alpha	10066810	LTP	1.00		-	PTPc	0.92	-	medium
S	1007	HDSDESSDDDSDSEEPSKYIN	CK2_alpha	10066810	LTP	1.00	MOD_CK2_1	-	PTPc	0.81	-	medium

Substrate:

CD5 (T-cell surface glycoprotein CD5 precursor (Lymphocyte glycoprotein T1/Leu-1) (Lymphocyte antigen CD5))

Seq-ID:

P06127 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
scavenger receptor activity	integral to plasma membrane	cell recognition, cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	482	LHRSSMQPDNSSDSDYDLHGA	CK2_alpha	9834084	LTP	1.00	-	-	0.69	-	medium
S	483	HRSSMQPDNSSDSDYDLHGAQ	CK2_alpha	9834084	LTP	1.00	-	-	0.69	-	medium
S	485	SSMQPDNSSDSDYDLHGAQRL	CK2_alpha	9834084	LTP	1.00	-	-	0.72	-	medium

Substrate:

cdc25B (Dual specificity phosphatase)

Seq-ID:

P30305 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19329   1433Z_HUMAN
MINT-19330   1433F_HUMAN
MINT-25122   1433B_HUMAN
MINT-51069   1433S_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein tyrosine phosphatase activity, protein binding	cytosol, microtubule organizing center, nucleoplasm	positive regulation of cell proliferation, cell division, protein amino acid dephosphorylation, mitosis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	186	RKSEAGSGAASSSGEDKENDG	CK2_alpha	12527891	LTP	0.18	MOD_CK2_1	-	M-inducer_phosp	0.81	-	medium
S	187	KSEAGSGAASSSGEDKENDGF	CK2_alpha	12527891	LTP	0.07	MOD_CK2_1	-	M-inducer_phosp	0.77	-	medium

Substrate:

Cell division control protein 2 (Cell division control protein 2 homolog (EC 2.7.1.-) (p34 protein kinase) (Cyclin-dependent kinase 1) (CDK1))

Seq-ID:

P06493 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-15829   1433S_HUMAN
MINT-73507   VE7_HPV16
MINT-77985   LT_SV40
MINT-1792672   TOPK_HUMAN
MINT-6166774   RGAP1_HUMAN
MINT-6549466   EF2K_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cyclin-dependent protein kinase activity, ATP binding, RNA polymerase II carboxy-terminal domain kinase activity	midbody, spindle microtubule, cytosol, nucleoplasm	cell division, positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, anti-apoptosis, protein localization to kinetochore, mitosis, anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	39	VVAMKKIRLESEEEGVPSTAI	CK2_alpha	1400350	LTP	0.51	MOD_CK2_1	-	S_TKc	0.33	-	medium

Substrate:

CHOP (Transcription factor)

Seq-ID:

P35638 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-67504 CJ119_HUMAN
MINT-68453 BATF_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, protein dimerization activity, transcription corepressor activity, sequence-specific DNA binding transcription factor activity	nucleus	regulation of transcription in response to stress, cell cycle arrest, cell redox homeostasis, response to DNA damage stimulus, regulation of transcription, DNA-dependent, mRNA transcription from RNA polymerase II promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	14	ESLPFSFGTLSSWELEAWYED	CK2_alpha	12876286	LTP	1.00	MOD_CK2_1	-	-	0.39	-	low
S	15	SLPFSFGTLSSWELEAWYEDL	CK2_alpha	12876286	LTP	1.00	MOD_CK2_1	-	-	0.38	-	low
S	31	WYEDLQEVLSSDENGGTYVSP	CK2_alpha	12876286	LTP	1.00	MOD_CK2_1	-	-	0.72	-	low

Substrate:

Coagulation factor V (Coagulation factor V)

Seq-ID:

P12259 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
oxidoreductase activity, copper ion binding	plasma membrane, extracellular region, platelet alpha granule lumen	blood coagulation, oxidation reduction, cell adhesion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	720	HDRLEPEDEESDADYDYQNRL	CK2_alpha	9525959	LTP	0.00		-	-	0.67	-	medium

Substrate:

Complement C1r subcomponent (complement C1R component precursor (EC 3.4.21.41) (from PhosphoBase))

Seq-ID:

P00736 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium ion binding, serine-type endopeptidase activity	extracellular region	proteolysis, innate immune response, complement activation, classical pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	206	ELYTEASGYISSLEYPRSYPP	CK2_alpha	8635594	LTP	1.00	MOD_CK2_1	-	CUB	0.29	-	low
S	206	ELYTEASGYISSLEYPRSYPP	CK2_alpha	8635594	LTP	1.00	MOD_CK2_1	-	CUB	0.29	-	low

Substrate:

DNA topoisomerase II, alpha (DNA topoisomerase II alpha)

Seq-ID:

P11388 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-15316 PIN1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein kinase C binding, DNA topoisomerase (ATP-hydrolyzing) activity, protein heterodimerization activity, protein C-terminus binding, protein homodimerization activity, DNA-dependent ATPase activity, chromatin binding, histone deacetylase binding, ATP binding, ubiquitin binding, drug binding	DNA topoisomerase complex (ATP-hydrolyzing), cytoplasm, chromosome, nucleoplasm	DNA repair, chromosome segregation, phosphoinositide-mediated signaling, positive regulation of apoptosis, DNA ligation, apoptotic chromosome condensation, DNA topological change, DNA replication, positive regulation of retroviral genome replication

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	1377	KELKPQKSVVSDLEADDVKGS	CK2_alpha	7961967	LTP	0.43	MOD_CK2_1	-	-	0.77	-	-
S	1525	AKKPIKYLEESDEDDLF	CK2_alpha	7961967	LTP	0.95		-	-	0.51	-	-

Substrate:

E-cadherin (Epithelial-cadherin precursor (E-cadherin) (Uvomorulin) (Cadherin-1) (CAM 120/80))

Seq-ID:

P09803 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-46039 GSK3B_RAT

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium ion binding, protein domain specific binding, beta-catenin binding, protein phosphatase binding, RPTP-like protein binding	cell-cell adherens junction, basolateral plasma membrane, integral to membrane, apical part of cell	protein metabolic process, trophectodermal cell differentiation, protein homooligomerization, regulation of branching involved in salivary gland morphogenesis, salivary gland cavitation, homophilic cell adhesion, regulation of caspase activity

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	840	DSLLVFDYEGSGSEAASLSSL	CK2_alpha	10671552	LTP	1.00	MOD_CK2_1	-	Cadherin_C	0.47	1I7W	99.18%
S	853	EAASLSSLNSSESDQDQDYDY	CK2_alpha	10671552	LTP	1.00		-	Cadherin_C	0.73	-	-
S	855	ASLSSLNSSESDQDQDYDYLN	CK2_alpha	10671552	LTP	1.00		-	Cadherin_C	0.68	-	-

Substrate:

E2-CDC34 (Enzyme: Ligase)

Seq-ID:

P49427 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-15215 CSK21_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
ATP binding, protein binding, ubiquitin-protein ligase activity	cytoplasm, nucleus	regulation of protein metabolic process, proteasomal ubiquitin-dependent protein catabolic process, G1/S transition of mitotic cell cycle, protein K48-linked ubiquitination, negative regulation of cAMP-mediated signaling, DNA-dependent DNA replication initiation, protein polyubiquitination

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	231	DSCFGDDEDDSGTEES	CK2_alpha	11546811	LTP	0.73	MOD_CK2_1	-	-	0.78	-	medium
S	231	DSCFGDDEDDSGTEES	CK2_alpha	12037680	LTP	0.73	MOD_CK2_1	-	-	0.78	-	medium

Substrate:

eIF-5 (Eukaryotic translation initiation factor 5 (eIF-5))

Seq-ID:

P55010 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
GTPase activity, translation initiation factor activity, GTP binding	cytosol

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	389	IKWLKEAEEESSGGEEEDEDE	CK2_alpha	16227438	LTP	1.00	MOD_CK2_1	-	W2	0.59	2IU1	76.23%
S	390	KWLKEAEEESSGGEEEDEDEN	CK2_alpha	16227438	LTP	0.95	MOD_CK2_1	-	W2	0.62	2IU1	43.44%

Substrate:

eIF-5 (Eukaryotic translation initiation factor 5 (eIF-5))

Seq-ID:

Q07205 [Rattus norvegicus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
translation initiation factor activity, GTP binding

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	174	KGKDKENGSVSTSETPPPPPP	CK2_alpha	11861906	LTP	0.91	MOD_CK2_1	-	-	0.95	-	medium
S	387	IKWLKEAEEESSGGEEEDEDE	CK2_alpha	11861906	LTP	1.00	MOD_CK2_1	-	W2	0.59	-	medium
S	388	KWLKEAEEESSGGEEEDEDEN	CK2_alpha	11861906	LTP	0.93	MOD_CK2_1	-	W2	0.62	-	medium

Substrate:

ERCC3 (3' to 5' DNA helicase activity, damaged DNA binding)

Seq-ID:

P19447 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein C-terminus binding, ATP binding, damaged DNA binding, transcription factor binding, protein N-terminus binding, 3`-5` DNA helicase activity	holo TFIIH complex	hair cell differentiation, nucleotide-excision repair, DNA incision, response to oxidative stress, nucleotide-excision repair, DNA damage removal, DNA topological change, nucleotide-excision repair, DNA duplex unwinding, interspecies interaction between organisms, transcription initiation from RNA polymerase II promoter, RNA elongation from RNA polymerase II promoter, induction of apoptosis, positive regulation of transcription from RNA polymerase II promoter, cell cycle checkpoint, protein localization, transcription-coupled nucleotide-excision repair

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	751	SRRFGTMSSMSGADDTVYMEY	CK2_alpha	15549133	LTP	0.98		-	-	0.39	-	medium

Substrate:

FAS-associated factor 1 (FAS-associated factor 1)

Seq-ID:

Q9UNN5 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-62159 SNIP1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein kinase regulator activity, protein kinase binding, heat shock protein binding, NF-kappaB binding	cytosol, perinuclear region of cytoplasm, CD95 death-inducing signaling complex	cytoplasmic sequestering of NF-kappaB, proteasomal ubiquitin-dependent protein catabolic process, apoptosis, positive regulation of apoptosis, positive regulation of protein complex assembly, regulation of protein catabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	289	EEQITDVHMVSDSDGDDFEDA	CK2_alpha	11378439	LTP	1.00	-	-	0.56	-	-
S	289	EEQITDVHMVSDSDGDDFEDA	CK2_alpha	12832043	LTP	1.00	-	-	0.56	-	-
S	291	QITDVHMVSDSDGDDFEDATE	CK2_alpha	11378439	LTP	1.00	-	-	0.51	-	-
S	291	QITDVHMVSDSDGDDFEDATE	CK2_alpha	12832043	LTP	1.00	-	-	0.51	-	-

Substrate:

GMF-beta (Glia maturation factor)

Seq-ID:

P60983 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
enzyme activator activity, protein kinase inhibitor activity, growth factor activity, actin binding, signal transducer activity	intracellular	nervous system development, protein amino acid phosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	53	VVLDEELEGISPDELKDELPE	CK2_alpha	9030586	LTP	1.00	MOD_CK2_1	-	ADF	0.41	-	medium

Substrate:

Histone deacetylase 1 (Cell cycle control protein)

Seq-ID:

Q13547 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-49667   SP1_HUMAN
MINT-50169   NFKB1_HUMAN
MINT-50171   TF65_HUMAN
MINT-73393   VE7_HPV16
MINT-1957407   HIF1A_HUMAN
MINT-1957435   MTA1_HUMAN
MINT-4303210   DHX30_HUMAN
MINT-4303486   NR2E3_HUMAN
MINT-4303628   RBBP7_HUMAN
MINT-4544899   NPM_HUMAN
MINT-6628404   RB_HUMAN
MINT-6628780   LT_SV40
MINT-6823807   CTNB1_HUMAN
MINT-7302173   BUB1B_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
identical protein binding, specific transcriptional repressor activity, transcription activator activity, histone deacetylase activity, histone deacetylase binding, transcription factor binding, sequence-specific DNA binding transcription factor activity	Sin3 complex, cytosol, NuRD complex	negative regulation of gene-specific transcription from RNA polymerase II promoter, positive regulation of cell proliferation, positive regulation of gene-specific transcription from RNA polymerase II promoter, transcription, negative regulation by host of viral transcription, histone H4 deacetylation, anti-apoptosis, histone H3 deacetylation, positive regulation of receptor biosynthetic process, chromatin remodeling, negative regulation of cell cycle

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	421	DKRIACEEEFSDSEEEGEGGR	CK2_alpha	11602581	LTP	0.35	MOD_CK2_1	-	-	0.73	-	medium
S	423	RIACEEEFSDSEEEGEGGRKN	CK2_alpha	11602581	LTP	0.42	MOD_CK2_1	-	-	0.76	-	medium

Substrate:

Histone deacetylase 2 (Enzyme: Deacetylase)

Seq-ID:

Q92769 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-73394   VE7_HPV16
MINT-73396   RB_HUMAN
MINT-4054286   MYBB_HUMAN
MINT-4544944   NPM_HUMAN
MINT-7302197   BUB1B_HUMAN
MINT-7761068   SRA1_HUMAN
MINT-7971268   DLG4_RAT

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, specific transcriptional repressor activity, transcription activator activity, histone deacetylase activity, enzyme binding, transcription factor binding	ESC/E(Z) complex, Sin3 complex, cytoplasm, NuRD complex	negative regulation of gene-specific transcription from RNA polymerase II promoter, positive regulation of cell proliferation, negative regulation of transcription factor activity, positive regulation of gene-specific transcription from RNA polymerase II promoter, positive regulation of proteolysis, transcription, histone deacetylation, positive regulation of receptor biosynthetic process, chromatin remodeling, negative regulation of MHC class II biosynthetic process, positive regulation of collagen biosynthetic process, maintenance of chromatin silencing, negative regulation of cell cycle

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	394	AIPEDAVHEDSGDEDGEDPDK	CK2_alpha	12082111	LTP	0.17	MOD_CK2_1	-	-	0.88	-	medium

Substrate:

hnRPA1 (RNA binding protein)

Seq-ID:

P09651 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-48852   M3K14_HUMAN
MINT-62794   BAT2_HUMAN
MINT-3296922   1433Z_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
nucleotide binding, single-stranded RNA binding, single-stranded DNA binding, protein binding	spliceosomal complex, cytoplasm, nucleolus, nucleoplasm, heterogeneous nuclear ribonucleoprotein complex	mRNA transport, nuclear import, interspecies interaction between organisms, RNA export from nucleus

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	199	ASSSQRGRSGSGNFGGGRGGG	CK2_alpha	8451194	LTP	0.27		-	-	0.70	-	-

Substrate:

HSF 1 (Transcription factor)

Seq-ID:

Q00613 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-1785958 STUB1_HUMAN
MINT-6743391 STRAP_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding transcription factor activity, protein binding	cytoplasm	transcription, regulation of transcription, DNA-dependent

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	142	IRQDSVTKLLTDVQLMKGKQE	CK2_alpha	12659875	LTP	0.15		-	HSF_DNA-bind	0.33	-	high

Substrate:

HSP 90-alpha (heat shock protein HSP 90-alpha (HSP 86) (from PhosphoBase))

Seq-ID:

P07900 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13696   SYEP_HUMAN
MINT-17372   SYMC_HUMAN
MINT-17385   SYQ_HUMAN
MINT-48053   IKKA_HUMAN
MINT-48091   IKKB_HUMAN
MINT-48120   IKKE_HUMAN
MINT-48190   NEMO_HUMAN
MINT-48342   M3K1_HUMAN
MINT-48497   M3K3_HUMAN
MINT-48682   NFKB1_HUMAN
MINT-48760   NFKB2_HUMAN
MINT-48857   M3K14_HUMAN
MINT-49053   RIPK1_HUMAN
MINT-49073   RIPK2_HUMAN
MINT-49177   TAB1_HUMAN
MINT-49213   TAB2_HUMAN
MINT-49282   TBK1_HUMAN
MINT-63931   RS3A_HUMAN
MINT-3305183   1433Z_HUMAN
MINT-3373863   LCK_HUMAN
MINT-3374106   ZAP70_HUMAN
MINT-3378991   FKBP8_HUMAN
MINT-6550966   HIF1A_HUMAN
MINT-7710224   FKBP4_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein homodimerization activity, TPR domain binding, unfolded protein binding, nitric-oxide synthase regulator activity, ATP binding	cytosol, melanosome	mitochondrial outer membrane translocase complex assembly, response to unfolded protein, positive regulation of nitric oxide biosynthetic process, mitochondrial transport, signal transduction, protein refolding, cellular chaperone-mediated protein complex assembly

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	263	EDKPEIEDVGSDEEEEKKDGD	CK2_alpha	2492519	LTP	0.10	MOD_CK2_1	-	HSP90	0.78	-	-
S	263	EDKPEIEDVGSDEEEEKKDGD	CK2_alpha	2492519	LTP	0.10	MOD_CK2_1	-	HSP90	0.78	-	-

Substrate:

HSP 90-beta (heat shock protein HSP 90-beta (HSP 84) (HSP 90) (from PhosphoBase))

Seq-ID:

P08238 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14037   KSR1_MOUSE
MINT-48062   IKKA_HUMAN
MINT-48093   IKKB_HUMAN
MINT-48125   IKKE_HUMAN
MINT-48239   NEMO_HUMAN
MINT-48358   M3K1_HUMAN
MINT-48520   M3K3_HUMAN
MINT-48688   NFKB1_HUMAN
MINT-48880   M3K14_HUMAN
MINT-49055   RIPK1_HUMAN
MINT-49181   TAB1_HUMAN
MINT-49292   TBK1_HUMAN
MINT-50960   1433B_HUMAN
MINT-65424   DDX24_HUMAN
MINT-72641   HSP71_HUMAN
MINT-72642   TCPA_HUMAN
MINT-72643   HS105_HUMAN
MINT-72644   PRKDC_HUMAN
MINT-72645   GNAI2_HUMAN
MINT-72646   XPO1_HUMAN
MINT-72647   KPYM_HUMAN
MINT-72648   G3P_HUMAN
MINT-72649   PGK1_HUMAN
MINT-72650   LDHA_HUMAN
MINT-72651   ALDOA_HUMAN
MINT-72654   FAS_HUMAN
MINT-72659   ACTG_HUMAN
MINT-72660   TPM3_HUMAN
MINT-72661   FLNA_HUMAN
MINT-72662   MYH9_HUMAN
MINT-72663   SPTA2_HUMAN
MINT-72664   NUMA1_HUMAN
MINT-72665   ACTN1_HUMAN
MINT-72666   UBA1_HUMAN
MINT-72667   PSMD1_HUMAN
MINT-72669   SYAC_HUMAN
MINT-72670   SYIM_HUMAN
MINT-72671   EF2_HUMAN
MINT-72672   EIF3H_HUMAN
MINT-72674   RLA0_HUMAN
MINT-72675   RS6_HUMAN
MINT-72677   RL7_HUMAN
MINT-72678   RS3A_HUMAN
MINT-72680   RL5_HUMAN
MINT-1786001   STUB1_HUMAN
MINT-3319575   1433Z_HUMAN
MINT-6550980   HIF1A_HUMAN
MINT-7021862   AIP_HUMAN
MINT-7021879   4EBP1_HUMAN
MINT-7305157   SGT1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
TPR domain binding, unfolded protein binding, nitric-oxide synthase regulator activity, ATP binding	melanosome	response to unfolded protein, positive regulation of nitric oxide biosynthetic process, protein folding, regulation of interferon-gamma-mediated signaling pathway, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, regulation of type I interferon-mediated signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	226	YLEKEREKEISDDEAEEEKGE	CK2_alpha	2492519	LTP	0.69	MOD_CK2_1	-	HSP90	0.70	-	-
S	255	EEKPKIEDVGSDEEDDSGKDK	CK2_alpha	2492519	LTP	0.12	MOD_CK2_1	-	HSP90	0.77	-	-

Substrate:

HSP-E7I (Heat shock-related protein)

Seq-ID:

Q61699 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
ATP binding, protein binding	cytoplasm, nucleus	response to stress, chaperone mediated protein folding requiring cofactor

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	509	EKVPTEEEDGSSLEADMECPN	CK2_alpha	12558502	LTP	0.05	MOD_CK2_1	-	HSP70	0.84	-	low

Substrate:

Hsp90 co-chaperone Cdc37 (Chaperone)

Seq-ID:

Q16543 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13837   KSR1_MOUSE
MINT-47951   IKKA_HUMAN
MINT-48072   IKKB_HUMAN
MINT-48099   IKKE_HUMAN
MINT-48158   NEMO_HUMAN
MINT-48292   M3K1_HUMAN
MINT-48407   M3K3_HUMAN
MINT-48807   M3K14_HUMAN
MINT-49260   TBK1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
unfolded protein binding, heat shock protein binding	cytoplasm	regulation of cyclin-dependent protein kinase activity, protein targeting, regulation of interferon-gamma-mediated signaling pathway, regulation of type I interferon-mediated signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	13	DYSVWDHIEVSDDEDETHPNI	CK2_alpha	12930845	LTP	1.00	MOD_CK2_1	-	CDC37_N	0.55	-	-
S	13	DYSVWDHIEVSDDEDETHPNI	CK2_alpha	15082798	LTP	1.00	MOD_CK2_1	-	CDC37_N	0.55	-	-

Substrate:

Hypothetical protein FLJ20419. (ligase activity, ubiquitin-protein ligase activity)

Seq-ID:

Q712K3 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
ATP binding, ubiquitin-protein ligase activity		regulation of protein metabolic process, protein monoubiquitination, protein K48-linked ubiquitination

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	233	EDADCYDDDDSGNEES	CK2_alpha	12037680	LTP	0.28	MOD_CK2_1	BTRC WD40	-	0.83	-	medium

Substrate:

IFI 16 (Transcription regulatory protein)

Seq-ID:

Q16666 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-1781599 ANDR_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription repressor activity, double-stranded DNA binding, protein binding	cytoplasm, nucleolus, nucleoplasm	transcription, monocyte differentiation, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, regulation of transcription, DNA-dependent, cell proliferation, response to virus

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	132	ATPGAQKRKKSTKEKAGPKGS	CK2_alpha	11115400	LTP	0.00	MOD_CK2_1	-	-	0.87	-	medium

Substrate:

IGF2R (insulin-like growth factor receptor activity, receptor activity)

Seq-ID:

P11717 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-16907   GGA1_HUMAN
MINT-3372208   PACS1_HUMAN
MINT-3372318   TGON2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
insulin-like growth factor receptor activity, glycoprotein binding, transporter activity, phosphoprotein binding	lysosomal membrane, endosome, trans-Golgi network transport vesicle, integral to plasma membrane, cell surface, endocytic vesicle	receptor-mediated endocytosis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	2409	LSSLHGDDQDSEDEVLTIPEV	CK2_alpha	8318012	LTP	1.00	MOD_CK2_1	-	-	0.59	-	medium
S	2484	STKLVSFHDDSDEDLLHI	CK2_alpha	8318012	LTP	1.00		-	-	0.51	-	medium

Substrate:

IKB-alpha (Major histocompatibility complex enhancer-binding protein MAD3)

Seq-ID:

P25963 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-47837   REL_HUMAN
MINT-47839   IKBB_HUMAN
MINT-47840   ELP1_HUMAN
MINT-47841   IKKA_HUMAN
MINT-47842   IKKB_HUMAN
MINT-47843   NEMO_HUMAN
MINT-47845   MCM7_HUMAN
MINT-48656   NFKB1_HUMAN
MINT-48721   NFKB2_HUMAN
MINT-48993   RELB_HUMAN
MINT-64895   MED19_HUMAN
MINT-6762163   PTN1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
nuclear localization sequence binding, identical protein binding, ubiquitin protein ligase binding, NF-kappaB binding	cytosol, I-kappaB/NF-kappaB complex, nucleus	positive regulation of gene-specific transcription from RNA polymerase II promoter, cytoplasmic sequestering of NF-kappaB, negative regulation of NF-kappaB transcription factor activity, apoptosis, anti-apoptosis, negative regulation of lipid storage, negative regulation of macrophage derived foam cell differentiation, positive regulation of cholesterol efflux, interspecies interaction between organisms, positive regulation of cellular protein metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	283	TLENLQMLPESEDEESYDTES	CK2_alpha	8622692	LTP	1.00	MOD_CK2_1	-	-	0.65	1IKN	91.80%
S	288	QMLPESEDEESYDTESEFTEF	CK2_alpha	8622692	LTP	1.00	MOD_CK2_1	-	-	0.70	1IKN	17.21%
T	291	PESEDEESYDTESEFTEFTED	CK2_alpha	8622692	LTP	0.00	MOD_CK2_1	-	-	0.73	1IKN	45.89%
S	293	SEDEESYDTESEFTEFTEDEL	CK2_alpha	12167702	LTP	0.79	MOD_CK2_1	-	-	0.73	1IKN	0.0%

Substrate:

IKB-alpha (Major histocompatibility complex enhancer-binding protein MAD3)

Seq-ID:

Q9Z1E3 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19530   TF65_MOUSE
MINT-50016   TF65_HUMAN
MINT-50067   KAPCA_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	cytosol, nucleus	negative regulation of myeloid cell differentiation, negative regulation of Notch signaling pathway, lipopolysaccharide-mediated signaling pathway, response to exogenous dsRNA, nucleotide-binding oligomerization domain containing 2 signaling pathway, regulation of cell proliferation, nucleotide-binding oligomerization domain containing 1 signaling pathway, protein import into nucleus, translocation, response to muramyl dipeptide, toll-like receptor 4 signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	293	SEDEESYDTESEFTEDELPYD	CK2_alpha	8668171	LTP	0.07	MOD_CK2_1	-	-	0.72	-	medium

Substrate:

Lupus La protein (lupus La protein (Sfogren syndrome type B antigen) (SS-B) (from PhosphoBase))

Seq-ID:

P05455 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-48798 M3K14_HUMAN
MINT-3297068 1433Z_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
nucleotide binding, tRNA binding, mRNA binding, protein binding	cytoplasm, ribonucleoprotein complex, nucleolus	tRNA modification, histone mRNA metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	366	QFQGKKTKFASDDEHDEHDEN	CK2_alpha	15485924	LTP	0.84	MOD_CK2_1	-	-	0.80	-	-
S	366	QFQGKKTKFASDDEHDEHDEN	CK2_alpha	9054510	LTP	0.84	MOD_CK2_1	-	-	0.80	-	-
S	366	QFQGKKTKFASDDEHDEHDEN	CK2_alpha	9054510	LTP	0.84	MOD_CK2_1	-	-	0.80	-	-

Substrate:

Max protein (Max protein)

Seq-ID:

P61244 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-25075 MYC_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription coactivator activity, sequence-specific DNA binding transcription factor activity	cytoplasm, MLL1 complex	transcription from RNA polymerase II promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	2	MSDNDDIEVESD	CK2_alpha	8247525	LTP	0.33		-	-	0.57	-	-
S	2	MSDNDDIEVESD	CK2_alpha	7735324	LTP	0.33		-	-	0.57	-	-
S	11	MSDNDDIEVESDEEQPRFQSA	CK2_alpha	8247525	LTP	0.83	MOD_CK2_1	-	-	0.79	1HLO	47.54%
S	11	MSDNDDIEVESDEEQPRFQSA	CK2_alpha	7735324	LTP	0.83	MOD_CK2_1	-	-	0.79	1HLO	47.54%

Substrate:

Mitogen-activated protein kinase 9 (Mitogen-activated protein kinase 9)

Seq-ID:

P45984 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-64910   XPO7_HUMAN
MINT-66639   K1712_HUMAN
MINT-68376   WDR62_HUMAN
MINT-7148323   JUN_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
JUN kinase activity, ATP binding, protein binding	nucleoplasm	positive regulation of macrophage derived foam cell differentiation, positive regulation of gene expression

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	404	NDISSMSTEQTLASDTDSSLD	CK2_alpha	11062067	LTP	1.00		-	-	0.72	-	low
S	407	SSMSTEQTLASDTDSSLDAST	CK2_alpha	11062067	LTP	0.83		-	-	0.77	-	low

Substrate:

Myocyte-specific enhancer factor 2A (Transcription factor)

Seq-ID:

Q02078 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-49703   HDAC4_HUMAN
MINT-3380349   SUMO1_HUMAN
MINT-7973732   DLG4_RAT

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, sequence-specific DNA binding transcription factor activity	nucleoplasm	nervous system development, transcription, apoptosis, muscle organ development, regulation of transcription, DNA-dependent, cell differentiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	289	PSSKGMMPPLSEEEELELNTQ	CK2_alpha	12586839	LTP	0.11	MOD_CK2_1	-	-	0.82	-	medium

Substrate:

Myocyte-specific enhancer factor 2C (Myocyte-specific enhancer factor 2C)

Seq-ID:

Q8CFN5 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19703   HDAC7_MOUSE
MINT-19713   TRIP6_MOUSE
MINT-19740   ACLY_MOUSE
MINT-19791   CTRO_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, transcription activator activity, histone deacetylase binding, sequence-specific DNA binding transcription factor activity	nucleus	nervous system development, outflow tract morphogenesis, transcription, smooth muscle cell differentiation, apoptosis, blood vessel remodeling, osteoblast differentiation, endochondral ossification, cardiac cell differentiation, cardiac ventricle formation, skeletal muscle tissue development, muscle cell fate determination, positive regulation of protein homodimerization activity, positive regulation of transcription from RNA polymerase II promoter, chondrocyte differentiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	59	NSTNKLFQYASTDMDKVLLKY	CK2_alpha	8663403	LTP	1.00		-	MADS	0.22	1EGW	31.15%

Substrate:

n-myc (N-myc proto-oncogene protein.)

Seq-ID:

P04198 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding transcription factor activity, protein binding	chromatin, nucleus	regulation of transcription from RNA polymerase II promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	261	ALSTSGEDTLSDSDDEDDEEE	CK2_alpha	1425701	LTP	0.21	MOD_CK2_1	-	Myc_N	0.96	-	low
S	263	STSGEDTLSDSDDEDDEEEDE	CK2_alpha	1425701	LTP	0.18	MOD_CK2_1	-	Myc_N	0.97	-	low

Substrate:

p65 (Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit), RelA)

Seq-ID:

Q04206 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-50016   IKBA_MOUSE
MINT-50017   IKBB_MOUSE
MINT-50025   KAPCA_HUMAN
MINT-50073   KS6A5_HUMAN
MINT-50084   KPCZ_HUMAN
MINT-50090   CSK21_HUMAN
MINT-50107   IKKA_HUMAN
MINT-50167   IKKB_HUMAN
MINT-50171   HDAC1_HUMAN
MINT-50175   KAT2B_HUMAN
MINT-50178   EP300_HUMAN
MINT-50179   HDAC3_HUMAN
MINT-58638   NCF1_HUMAN
MINT-62399   TF2B_HUMAN
MINT-2834593   NCOA3_HUMAN
MINT-6166971   OGT1_HUMAN
MINT-7235700   ASPP2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription repressor activity, transcription repressor binding, identical protein binding, protein kinase binding, ubiquitin protein ligase binding, transcription activator binding, transcription activator activity, RNA polymerase II transcription factor activity, enhancer binding, promoter binding, protein N-terminus binding, phosphate binding, NF-kappaB binding	cytosol, transcription factor complex	transcription, positive regulation of I-kappaB kinase/NF-kappaB cascade, cytokine-mediated signaling pathway, anti-apoptosis, defense response to virus, membrane protein intracellular domain proteolysis, cellular defense response, inflammatory response, nucleotide-binding oligomerization domain containing 2 signaling pathway, response to interleukin-1, interspecies interaction between organisms, positive regulation of NF-kappaB transcription factor activity, positive regulation of transcription from RNA polymerase II promoter, response to UV-B, negative regulation of gene-specific transcription

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	529	GAPGLPNGLLSGDEDFSSIAD	CK2_alpha	10938077	LTP	0.55	MOD_CK2_1	-	-	0.52	-	-

Substrate:

PIP5K2A (PtdIns kinase)

Seq-ID:

P48426 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
1-phosphatidylinositol-5-phosphate 4-kinase activity, 1-phosphatidylinositol-4-phosphate 5-kinase activity, ATP binding		phosphatidylinositol metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	304	EENDGEEEGESDGTHPVGTPP	CK2_alpha	10508590	LTP	0.63		-	PIPKc	0.93	-	medium

Substrate:

PKB-alpha (RAC-alpha serine/threonine kinase (EC 2.7.1.-) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT))

Seq-ID:

P31749 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13835   PDPK1_HUMAN
MINT-15213   KS6B1_HUMAN
MINT-16737   FRAP_HUMAN
MINT-17680   CDN1B_HUMAN
MINT-74931   PP2AA_HUMAN
MINT-3379039   TOPB1_HUMAN
MINT-4820691   CASP3_HUMAN
MINT-6175251   STK4_HUMAN
MINT-6742762   TERT_HUMAN
MINT-6823537   MDM2_HUMAN
MINT-7014449   RAF1_HUMAN
MINT-7146767   PLCG1_HUMAN
MINT-7232672   KPCZ_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphatidylinositol-3,4-bisphosphate binding, protein serine/threonine kinase activity, phosphatidylinositol-3,4,5-trisphosphate binding, identical protein binding, nitric-oxide synthase regulator activity, ATP binding, enzyme binding	plasma membrane, cytosol, nucleoplasm	response to UV-A, positive regulation of cell growth, regulation of neuron projection development, positive regulation of cyclin-dependent protein kinase activity involved in G1/S, glycogen biosynthetic process, response to heat, negative regulation of fatty acid beta-oxidation, insulin-like growth factor receptor signaling pathway, peptidyl-serine phosphorylation, regulation of translation, protein amino acid autophosphorylation, positive regulation of nitric-oxide synthase activity, nitric oxide biosynthetic process, positive regulation of fat cell differentiation, positive regulation of glycogen biosynthetic process, positive regulation of lipid biosynthetic process, activation of pro-apoptotic gene products, negative regulation of plasma membrane long-chain fatty acid transport, positive regulation of establishment of protein localization in plasma membrane, insulin receptor signaling pathway, positive regulation of glucose import, negative regulation of protein kinase activity, response to fluid shear stress, activation-induced cell death of T cells, protein import into nucleus, translocation, G-protein coupled receptor protein signaling pathway, positive regulation of nitric oxide biosynthetic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	129	DFRSGSPSDNSGAEEMEVSLA	CK2_alpha	15818404	LTP	0.53	MOD_CK2_1	-	-	0.63	-	-

Substrate:

PKD2 (calcium ion binding, cytoskeletal protein binding)

Seq-ID:

Q13563 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
voltage-gated sodium channel activity, calcium ion binding, protein C-terminus binding, cytoskeletal protein binding, voltage-gated chloride channel activity	plasma membrane, microtubule basal body, integral to membrane, actin cytoskeleton, endoplasmic reticulum	organ morphogenesis, cell-matrix adhesion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	812	SRSFPRSLDDSEEDDDEDSGH	CK2_alpha	14742446	LTP	1.00		-	-	0.82	-	low

Substrate:

PP2C-alpha (Ser/Thr phosphatase)

Seq-ID:

P49443 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, manganese ion binding	protein serine/threonine phosphatase complex	protein amino acid dephosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	375	LNPYKNDDTDSASTDDMW	CK2_alpha	9688543	LTP	0.27		-	-	0.62	-	low
S	377	PYKNDDTDSASTDDMW	CK2_alpha	9688543	LTP	0.05		-	-	0.67	-	low

Substrate:

Presenilin 2 (Integral membrane protein)

Seq-ID:

P49810 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13995   FLNA_HUMAN
MINT-14380   FLNB_HUMAN
MINT-14946   B2CL1_HUMAN
MINT-16271   FHL2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein binding	centrosome, Golgi membrane, nuclear inner membrane, integral to plasma membrane, kinetochore, endoplasmic reticulum membrane	induction of apoptosis by extracellular signals, membrane protein ectodomain proteolysis, apoptosis, Notch receptor processing, membrane protein intracellular domain proteolysis, positive regulation of catalytic activity, Notch signaling pathway, amyloid precursor protein catabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	7	MLTFMASDSEEEVCDER	CK2_alpha	8972483	LTP	0.11	MOD_CK2_1	-	-	0.52	-	medium
S	9	MLTFMASDSEEEVCDERTS	CK2_alpha	8972483	LTP	0.94	MOD_CK2_1	-	-	0.53	-	medium
S	330	DPEMEEDSYDSFGEPSYPEVF	CK2_alpha	9558331	LTP	0.14	MOD_CK1_1	-	PSN	0.39	-	medium
S	335	EDSYDSFGEPSYPEVFEPPLT	CK2_alpha	9558331	LTP	0.06	MOD_CK2_1	-	PSN	0.30	-	medium

Substrate:

Progesterone receptor (Progesterone receptor (PR))

Seq-ID:

P06401 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-4788079 JDP2_HUMAN
MINT-4788120 NCOR2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
steroid binding, zinc ion binding, receptor binding, sequence-specific DNA binding transcription factor activity, protein binding, steroid hormone receptor activity	cytoplasm, nucleus	transcription, cell-cell signaling

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	81	DEKTQDQQSLSDVEGAYSRAE	CK2_alpha	7983041	LTP	0.81	MOD_CK2_1	-	Prog_receptor	0.85	-	medium

Substrate:

PTEN (Lipid phosphatase)

Seq-ID:

P60484 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-63918   SCG1_HUMAN
MINT-63919   HBA_HUMAN
MINT-63921   UT14A_HUMAN
MINT-2832448   NHRF1_HUMAN
MINT-2832646   NHRF2_HUMAN
MINT-2832742   NHRF2_MOUSE
MINT-2832984   PGFRB_HUMAN
MINT-6793823   CAV1_HUMAN
MINT-7266561   PRDX1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity, protein tyrosine phosphatase activity, phosphatidylinositol-3-phosphatase activity, lipid binding, protein serine/threonine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity, phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity, enzyme binding, inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity, PDZ domain binding	cytosol, nucleus	protein stabilization, inositol phosphate dephosphorylation, central nervous system development, regulation of cyclin-dependent protein kinase activity, regulation of neuron projection development, apoptosis, positive regulation of transcription factor activity, protein amino acid dephosphorylation, canonical Wnt receptor signaling pathway, phosphoinositide dephosphorylation, negative regulation of cell migration, induction of apoptosis, negative regulation of focal adhesion assembly, negative regulation of protein kinase B signaling cascade, cell proliferation, negative regulation of protein amino acid phosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	370	SSSTSVTPDVSDNEPDHYRYS	CK2_alpha	16107342	LTP	0.79	MOD_CK2_1	-	-	0.76	-	-
S	370	SSSTSVTPDVSDNEPDHYRYS	CK2_alpha	11035045	LTP	0.79	MOD_CK2_1	-	-	0.76	-	-
S	380	SDNEPDHYRYSDTTDSDPENE	CK2_alpha	11035045	LTP	1.00		-	-	0.87	-	-
T	382	NEPDHYRYSDTTDSDPENEPF	CK2_alpha	11035045	LTP	1.00	MOD_CK2_1	-	-	0.87	-	-
S	385	DHYRYSDTTDSDPENEPFDED	CK2_alpha	11035045	LTP	1.00	MOD_CK2_1	-	-	0.86	-	-

Substrate:

RING-box protein 2 (Enzyme: Ligase)

Seq-ID:

Q9UBF6 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
copper ion binding, zinc ion binding, NEDD8 ligase activity, protein binding	cytoplasm, nucleus	anti-apoptosis, protein neddylation, induction of apoptosis by oxidative stress, response to redox state

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	10	MADVEDGEETCALASHSGSS	CK2_alpha	12748192	LTP	0.36		-	-	0.32	-	low

Substrate:

RNA binding protein S1 (RNA binding protein)

Seq-ID:

Q15287 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-66637   SFRS6_HUMAN
MINT-67264   DVL2_HUMAN
MINT-2868817   UBQL4_HUMAN
MINT-7972584   DLG4_RAT

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
nucleotide binding, RNA binding, protein binding	cytoplasm, nuclear speck	mRNA processing, transcription, nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, RNA splicing

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	53	SKDKGATKESSEKDRGRDKTR	CK2_alpha	15684395	LTP	0.42		-	-	0.92	-	low

Substrate:

S-protein (Vitronectin precursor (Serum spreading factor) (S-protein) (V75) [Contains: Vitronectin V65 subunit; Vitronectin V10 subunit; Somatomedin B)

Seq-ID:

P04004 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
scavenger receptor activity, heparin binding, integrin binding	alphav-beta3 integrin-vitronectin complex, extracellular space	positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of protein binding, positive regulation of wound healing, positive regulation of smooth muscle cell migration, immune response, positive regulation of vascular endothelial growth factor receptor signaling pathway, positive regulation of receptor-mediated endocytosis, negative regulation of endopeptidase activity, cell-matrix adhesion, cell adhesion mediated by integrin, negative regulation of blood coagulation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	69	KPQVTRGDVFTMPEDEYTVYD	CK2_alpha	9733784	LTP	0.14	MOD_CK2_1	-	-	0.54	-	-
T	76	DVFTMPEDEYTVYDDGEEKNN	CK2_alpha	9733784	LTP	0.27		-	-	0.65	-	-

Substrate:

SPI1 (Transcription factor)

Seq-ID:

P17433 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sequence-specific DNA binding, transcription activator activity, RNA binding, sequence-specific DNA binding transcription factor activity, protein binding	transcription factor complex	macrophage differentiation, transcription, anatomical structure regression, positive regulation of transcription, DNA-dependent, erythrocyte differentiation, vasculature development, induction of apoptosis, lymphocyte differentiation, lymphoid progenitor cell differentiation, myeloid dendritic cell differentiation, granulocyte differentiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	148	GERQSPPLEVSDGEADGLEPG	CK2_alpha	8456286	LTP	1.00	MOD_CK2_1	-	-	0.84	-	medium

Substrate:

SRF (Serum response factor)

Seq-ID:

P11831 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-15523 MYOD1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein homodimerization activity, specific RNA polymerase II transcription factor activity, transcription factor binding, sequence-specific DNA binding transcription factor activity, serum response element binding	cytoplasm, nucleus	senescence, transcription, positive regulation of cell differentiation, neuron development, regulation of smooth muscle cell differentiation, response to hormone stimulus, response to toxin, positive regulation of transcription via serum response element binding, response to cytokine stimulus, heart looping, positive regulation of smooth muscle contraction, cell migration involved in sprouting angiogenesis, muscle cell homeostasis, trophectodermal cell differentiation, angiogenesis involved in wound healing, positive regulation of transcription initiation from RNA polymerase II promoter

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	77	TPAPTAGALYSGSEGDSESGE	CK2_alpha	2046671	LTP	0.53	MOD_CK2_1	-	-	0.81	-	-
S	79	APTAGALYSGSEGDSESGEEE	CK2_alpha	2046671	LTP	0.46	MOD_CK2_1	-	-	0.79	-	-
S	83	GALYSGSEGDSESGEEEELGA	CK2_alpha	2046671	LTP	0.67	MOD_CK2_1	-	-	0.77	-	-

Substrate:

SRPK1 (Serine/threonine-protein kinase)

Seq-ID:

Q96SB4 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-50939 1433B_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, protein serine/threonine kinase activity, ATP binding, protein binding	cytoplasm, nucleus	protein amino acid phosphorylation, regulation of mRNA processing, mRNA processing, chromosome segregation, interspecies interaction between organisms, RNA splicing, cell differentiation, intracellular protein kinase cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	222	LPEQEEEILGSDDDEQEDPND	CK2_alpha	12565829	LTP	0.31		-	-	0.83	-	-
S	726	ATGDYLFEPHSGEEYTRDEDH	CK2_alpha	12565829	LTP	0.09	MOD_CK2_1	-	STYKc	0.37	1WBP	51.64%

Substrate:

Stanniocalcin 2 (Peptide hormone)

Seq-ID:

O76061 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-63527   RPB3_HUMAN
MINT-63641   PEBP1_HUMAN
MINT-64092   PP1R8_HUMAN
MINT-64403   AIFM1_HUMAN
MINT-65805   CHSP1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
hormone activity	extracellular region	response to nutrient, cell-cell signaling, cell surface receptor linked signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	288	GLGAQGPSGSSEWEDEQSEYS	CK2_alpha	10947959	LTP	0.23	MOD_CK2_1	-	-	0.80	-	medium

Substrate:

Stress-induced-phosphoprotein 1 (Mediates the association of the molecular chaperones HSC70 and HSP90)

Seq-ID:

Q60864 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
binding	cytoplasm, nucleus

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	189	LSVLLGVDLGSMDEEEEAATP	CK2_alpha	11154072	LTP	0.56	MOD_CK2_1	-	-	0.68	-	medium

Substrate:

Structure specific recognition protein 1 (Transcription factor)

Seq-ID:

Q08945 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-2984249   MCM7_HUMAN
MINT-2984265   NEK9_HUMAN
MINT-2984307   MCM6_HUMAN
MINT-2984332   SP16H_HUMAN
MINT-2984350   MCM3_HUMAN
MINT-2984383   MCM2_HUMAN
MINT-2984401   MCM4_HUMAN
MINT-7264943   RPA34_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
DNA binding, protein binding	cytoplasm, chromosome, nucleoplasm	transcription, DNA repair, regulation of transcription, DNA replication

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	510	SASSSSNEGDSDRDEKKRKQL	CK2_alpha	15659405	LTP	0.33		-	-	0.84	-	medium
S	688	SKKKRRRSEDSEEEELASTPP	CK2_alpha	15659405	LTP	0.66	MOD_CK2_1	-	-	0.83	-	medium

Substrate:

TCF4 (protein binding, RNA polymerase II transcription factor acti...)

Seq-ID:

P15884 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-4508065 CTNB1_HUMAN
MINT-4790867 EP300_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein heterodimerization activity, protein C-terminus binding, armadillo repeat domain binding, beta-catenin binding, sequence-specific DNA binding transcription factor activity	nucleus	transcription, orbitofrontal cortex development, positive regulation of transcription, DNA-dependent, regulation of smooth muscle cell proliferation, cerebral cortex development

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	54	HFTGSNVEDRSSSGSWGNGGH	CK2_alpha	11711551	LTP	1.00	-	-	0.78	-	low
S	55	FTGSNVEDRSSSGSWGNGGHP	CK2_alpha	11711551	LTP	0.22	-	-	0.80	-	low
S	56	TGSNVEDRSSSGSWGNGGHPS	CK2_alpha	11711551	LTP	1.00	-	-	0.82	-	low

Substrate:

Telomerase-binding protein p23 (Chaperone)

Seq-ID:

Q15185 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
prostaglandin-E synthase activity, telomerase activity, unfolded protein binding	chromosome, telomeric region, cytosol, telomerase holoenzyme complex	chaperone cofactor-dependent protein refolding, prostaglandin biosynthetic process, signal transduction, telomere maintenance

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	113	FNNWKDWEDDSDEDMSNFDRF	CK2_alpha	15040786	LTP	0.10		-	-	0.41	-	-
S	118	DWEDDSDEDMSNFDRFSEMMN	CK2_alpha	15040786	LTP	0.08		-	-	0.52	-	-

Substrate:

TFPI (endopeptidase inhibitor activity)

Seq-ID:

P10646 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
serine-type endopeptidase inhibitor activity	plasma membrane, extracellular space	blood coagulation, extrinsic pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	30	NLAPAPLNADSEEDEEHTIIT	CK2_alpha	2122883	LTP	0.24		-	-	0.47	-	medium

Substrate:

Thyroid hormone receptor alpha (thyroid hormone receptor alpha (c-ErbA) (from PhosphoBase))

Seq-ID:

P63058 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-3374311 RXRA_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription repressor activity, thyroid hormone receptor activity, steroid receptor RNA activator RNA binding, zinc ion binding, steroid hormone receptor activity	nucleus	regulation of thyroid hormone mediated signaling pathway, regulation of lipid catabolic process, regulation of myeloid cell apoptosis, cartilage condensation, positive regulation of myotube differentiation, regulation of heart contraction, erythrocyte differentiation, response to cold, positive regulation of female receptivity, cytoplasmic sequestering of transcription factor, ossification, female courtship behavior, thyroid gland development, learning or memory

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	474	SSEASSLSSSSSDEDTEVFED	CK2_alpha	7739517	LTP	-	MOD_CK2_1	-	-	0.76	-	low
S	475	SEASSLSSSSSDEDTEVFEDL	CK2_alpha	7739517	LTP	-	MOD_CK2_1	-	-	0.74	-	low

Substrate:

TLE1 (transcription factor binding)

Seq-ID:

Q04724 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-60092   HIPK2_HUMAN
MINT-63367   KITH_HUMAN
MINT-63424   PROF1_HUMAN
MINT-63539   IF2B_HUMAN
MINT-63566   SAT1_HUMAN
MINT-63940   CH10_HUMAN
MINT-64819   Q86V38_HUMAN
MINT-65107   FUBP1_HUMAN
MINT-65274   MPH6_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
transcription factor binding	nucleus	transcription, organ morphogenesis, signal transduction, negative regulation of transcription, negative regulation of Wnt receptor signaling pathway, Wnt receptor signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	239	VDDKDSSHYDSDGDKSDDNLV	CK2_alpha	15367661	LTP	0.37		-	-	0.83	-	medium

Substrate:

vitamin D receptor (Vitamin D receptor)

Seq-ID:

P11473 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
vitamin D3 receptor activity, zinc ion binding, sequence-specific DNA binding transcription factor activity, retinoid X receptor binding, steroid hormone receptor activity		negative regulation of gene-specific transcription from RNA polymerase II promoter, transcription, decidualization, negative regulation of cell proliferation, regulation of calcidiol 1-monooxygenase activity, positive regulation of vitamin D 24-hydroxylase activity

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	208	DSSSFSNLDLSEEDSDDPSVT	CK2_alpha	8622969	LTP	0.23		-	-	0.55	-	medium
S	208	DSSSFSNLDLSEEDSDDPSVT	CK2_alpha	8384219	LTP	0.23		-	-	0.55	-	medium

Substrate:

WASP (Downstream effector molecule)

Seq-ID:

P42768 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13728   FGR_HUMAN
MINT-14050   ARC1B_HUMAN
MINT-14451   NCK1_HUMAN
MINT-14847   FYN_HUMAN
MINT-25018   CDC42_HUMAN
MINT-50148   PPIP1_HUMAN
MINT-50152   PTN12_HUMAN
MINT-73063   WBP4_HUMAN
MINT-7212499   LCK_HUMAN
MINT-7218827   SNX33_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
identical protein binding, small GTPase regulator activity	cytosol, actin cytoskeleton	epidermis development, blood coagulation, immune response, defense response

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	484	MQKRSRAIHSSDEGEDQAGDE	CK2_alpha	12769847	LTP	1.00	MOD_CK2_1	-	-	0.98	-	-

Substrate:

XRCC1 (protein binding)

Seq-ID:

P18887 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-51183   CSK21_HUMAN
MINT-7247230   FYN_HUMAN
MINT-7294862   3MG_HUMAN
MINT-7294920   DPOLL_HUMAN
MINT-7294936   PARP1_HUMAN
MINT-7294980   CHK2_HUMAN
MINT-7543857   H2AX_HUMAN
MINT-7543877   TYDP1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
damaged DNA binding, protein binding	nucleoplasm	single strand break repair

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	475	QEDIDIEGVQSEGQDNGAEDS	CK2_alpha	15066279	LTP	0.11		-	-	0.91	-	medium
S	485	SEGQDNGAEDSGDTEDELRRV	CK2_alpha	15066279	LTP	1.00	MOD_CK2_1	-	-	0.94	-	medium
T	488	QDNGAEDSGDTEDELRRVAEQ	CK2_alpha	15066279	LTP	0.04	MOD_CK2_1	-	-	0.93	-	medium
S	518	EENGEDPYAGSTDENTDSEEH	CK2_alpha	15066279	LTP	1.00	MOD_CK2_1	-	-	0.98	-	medium
T	519	ENGEDPYAGSTDENTDSEEHQ	CK2_alpha	15066279	LTP	1.00	MOD_CK2_1	-	-	0.98	-	medium
T	523	DPYAGSTDENTDSEEHQEPPD	CK2_alpha	15066279	LTP	0.19	MOD_CK2_1	-	-	0.97	-	medium
S	525	YAGSTDENTDSEEHQEPPDLP	CK2_alpha	15066279	LTP	0.31	MOD_CK2_1	-	-	0.97	-	medium