List of substrates found:


Substrate: 14-3-3 beta/alpha (14-3-3 protein beta/alpha (protein kinase C inhibitor protein-1) (from PhosphoBase))
Seq-ID: P31946 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13707   KSR1_MOUSE
MINT-13962   RIN1_HUMAN
MINT-15934   TPD53_HUMAN
MINT-17162   TSC2_HUMAN
MINT-19367   KS6A1_HUMAN
MINT-24750   BID_HUMAN
MINT-25122   MPIP2_HUMAN
MINT-48491   M3K3_HUMAN
MINT-50344   BRAF_HUMAN
MINT-50346   HSP71_HUMAN
MINT-50347   PI4KB_HUMAN
MINT-50348   U520_HUMAN
MINT-50938   LBR_HUMAN
MINT-50939   SRPK1_HUMAN
MINT-50940   PRKDC_HUMAN
MINT-50943   AFAD_HUMAN
MINT-50945   LARP1_HUMAN
MINT-50946   FRYL_HUMAN
MINT-50947   CSK21_HUMAN
MINT-50948   TSC1_HUMAN
MINT-50949   P85B_HUMAN
MINT-50950   KINH_HUMAN
MINT-50951   UBP8_HUMAN
MINT-50952   SF13A_HUMAN
MINT-50953   ZO2_HUMAN
MINT-50954   STK38_HUMAN
MINT-50956   ACINU_HUMAN
MINT-50957   RABX5_HUMAN
MINT-50958   MYCB2_HUMAN
MINT-50959   C1QBP_HUMAN
MINT-50960   HS90B_HUMAN
MINT-50961   S4A7_HUMAN
MINT-50962   EDC3_HUMAN
MINT-50963   E41L3_HUMAN
MINT-50964   RMD3_HUMAN
MINT-50967   MEP50_HUMAN
MINT-50969   GRP78_HUMAN
MINT-50970   RIOK1_HUMAN
MINT-50971   SON_HUMAN
MINT-50972   TBB5_HUMAN
MINT-50973   PARD3_HUMAN
MINT-50974   SRRM2_HUMAN
MINT-50975   KIF23_HUMAN
MINT-50976   GAPD1_HUMAN
MINT-50977   ALS2_HUMAN
MINT-50978   RGAP1_HUMAN
MINT-50979   M3K2_HUMAN
MINT-50980   OSBL3_HUMAN
MINT-50981   MILK1_HUMAN
MINT-50982   MPRIP_HUMAN
MINT-50983   FRMD6_HUMAN
MINT-50984   MARK3_HUMAN
MINT-50985   PI3R4_HUMAN
MINT-50986   ST38L_HUMAN
MINT-50987   DOCK4_HUMAN
MINT-50988   WEE1_HUMAN
MINT-50991   KLC1_HUMAN
MINT-50992   LSR_HUMAN
MINT-50995   RAI14_HUMAN
MINT-50997   MYCPP_HUMAN
MINT-50998   Q8IXP7_HUMAN
MINT-50999   IRS2_HUMAN
MINT-51527   MARK2_HUMAN
MINT-7233039   IRK2_MOUSE
MINT-7300434   GAB2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoserine binding,
protein domain specific binding,
histone deacetylase binding		 cytosol,
melanosome,
perinuclear region of cytoplasm		 cytoplasmic sequestering of protein,
negative regulation of protein amino acid dephosphorylation,
positive regulation of catalytic activity,
Ras protein signal transduction,
activation of pro-apoptotic gene products
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 186 FSVFYYEILNSPEKACSLAKT MAPK8 15696159
LTP
0.59
 MOD_ProDKin_1
 - 14_3_3
0.11
 2BQ0 15.57%

Substrate: 14-3-3 zeta/delta (14-3-3 protein zeta/delta (Protein kinase C inhibitor protein-1) (KCIP-1) (Factor activating exoenzyme S) (FAS))
Seq-ID: P63104 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14323   FOXO3_HUMAN
MINT-14772   PRLR_HUMAN
MINT-17015   IL9R_HUMAN
MINT-17278   KC1A_HUMAN
MINT-17367   TPD53_HUMAN
MINT-17571   RIN1_HUMAN
MINT-17818   ATX1_HUMAN
MINT-19329   MPIP2_HUMAN
MINT-19336   ADA23_HUMAN
MINT-45800   RAF1_HUMAN
MINT-48206   NEMO_HUMAN
MINT-48480   M3K3_HUMAN
MINT-50358   HSP71_HUMAN
MINT-50935   EGFR_HUMAN
MINT-51005   IF4A3_HUMAN
MINT-51010   TRA2B_HUMAN
MINT-51012   DFFA_HUMAN
MINT-51013   STK38_HUMAN
MINT-51018   E41L3_HUMAN
MINT-51019   MEP50_HUMAN
MINT-51020   RO52_HUMAN
MINT-51021   TBB5_HUMAN
MINT-51022   ZO2_HUMAN
MINT-51025   KLC4_HUMAN
MINT-51027   Q8IXP7_HUMAN
MINT-51051   K1C19_HUMAN
MINT-51052   K1C18_HUMAN
MINT-63980   KU70_HUMAN
MINT-74924   KAPCA_HUMAN
MINT-74925   P53_HUMAN
MINT-3294407   MPIP1_HUMAN
MINT-3294433   MPIP3_HUMAN
MINT-3294883   MARK2_HUMAN
MINT-3295089   NUMA1_HUMAN
MINT-3295217   PCM1_HUMAN
MINT-3295255   NDE1_HUMAN
MINT-3295375   WEE1_HUMAN
MINT-3295392   CDK18_HUMAN
MINT-3295415   CDK17_HUMAN
MINT-3295530   MARK3_HUMAN
MINT-3295552   BRAF_HUMAN
MINT-3295573   MPRIP_HUMAN
MINT-3295597   ARHG2_HUMAN
MINT-3295618   RHG21_HUMAN
MINT-3295674   GAPD1_HUMAN
MINT-3295696   ARHGG_HUMAN
MINT-3295740   ATLA2_HUMAN
MINT-3295774   LIPB1_HUMAN
MINT-3295882   IRS2_HUMAN
MINT-3295899   PDE3A_HUMAN
MINT-3295953   LIMA1_HUMAN
MINT-3295975   CALM_HUMAN
MINT-3295996   PARD3_HUMAN
MINT-3296030   SI1L3_HUMAN
MINT-3296068   APC_HUMAN
MINT-3296095   NOLC1_HUMAN
MINT-3296132   NUCL_HUMAN
MINT-3296152   NPM_HUMAN
MINT-3296187   PSMD2_HUMAN
MINT-3296221   THIO_HUMAN
MINT-3296237   PRDX1_HUMAN
MINT-3296270   CE170_HUMAN
MINT-3296359   PYRG1_HUMAN
MINT-3296408   NADK_HUMAN
MINT-3296440   NDKB_HUMAN
MINT-3296457   KITH_HUMAN
MINT-3296491   HDAC4_HUMAN
MINT-3296507   HDAC7_HUMAN
MINT-3296523   YBOX1_HUMAN
MINT-3296639   HAT1_HUMAN
MINT-3296655   H4_HUMAN
MINT-3296701   H2A1_HUMAN
MINT-3296729   SPT6H_HUMAN
MINT-3296749   DNMT1_HUMAN
MINT-3296781   RUVB2_HUMAN
MINT-3296831   HNRPF_HUMAN
MINT-3296856   HNRH2_HUMAN
MINT-3296872   HNRPK_HUMAN
MINT-3296888   PCBP1_HUMAN
MINT-3296904   HNRPC_HUMAN
MINT-3296922   ROA1_HUMAN
MINT-3296956   DDX1_HUMAN
MINT-3296972   DDX3X_HUMAN
MINT-3297068   LA_HUMAN
MINT-3297088   RS3_HUMAN
MINT-3297112   RLA0_HUMAN
MINT-3297147   RL19_HUMAN
MINT-3297169   RL5_HUMAN
MINT-3297185   RLA2_HUMAN
MINT-3297202   RS7_HUMAN
MINT-3297276   SYEP_HUMAN
MINT-3297301   PABP2_HUMAN
MINT-3297322   PABP4_HUMAN
MINT-3297360   GCN1L_HUMAN
MINT-3297377   IF4G1_HUMAN
MINT-3297431   EIF3F_HUMAN
MINT-3297456   EF2_HUMAN
MINT-3297472   EF1A1_HUMAN
MINT-3297494   EF1B_HUMAN
MINT-3297642   KINH_HUMAN
MINT-3297660   KLC2_HUMAN
MINT-3297714   DYHC1_HUMAN
MINT-3297730   TBA1B_HUMAN
MINT-3297793   VIME_HUMAN
MINT-3297814   LMNA_HUMAN
MINT-3297843   LMNB1_HUMAN
MINT-3297866   ANXA2_HUMAN
MINT-3297886   ANXA1_HUMAN
MINT-3297917   ACTB_HUMAN
MINT-3297984   TLN1_HUMAN
MINT-3298006   FSCN1_HUMAN
MINT-3298028   HAKAI_HUMAN
MINT-3298189   PROF1_HUMAN
MINT-3298215   COF1_HUMAN
MINT-3304213   K6PP_HUMAN
MINT-3304235   F262_HUMAN
MINT-3304340   FAS_HUMAN
MINT-3304385   ACSL4_HUMAN
MINT-3304469   G3P_HUMAN
MINT-3304487   KCRU_HUMAN
MINT-3304522   LDHB_HUMAN
MINT-3304540   LDHA_HUMAN
MINT-3304560   SPRE_HUMAN
MINT-3304637   KPYM_HUMAN
MINT-3304676   TKT_HUMAN
MINT-3304695   ALDOA_HUMAN
MINT-3304712   ENOA_HUMAN
MINT-3304765   TPIS_HUMAN
MINT-3304790   TCPQ_HUMAN
MINT-3304899   TCPA_HUMAN
MINT-3305086   CH60_HUMAN
MINT-3305120   GRP78_HUMAN
MINT-3305183   HS90A_HUMAN
MINT-3305276   HS105_HUMAN
MINT-3305331   HSPB1_HUMAN
MINT-3305423   PPIA_HUMAN
MINT-3305616   TRAP1_HUMAN
MINT-3305679   HS71L_HUMAN
MINT-3305799   IPO7_HUMAN
MINT-3305862   IMB1_HUMAN
MINT-3306240   TIF1B_HUMAN
MINT-3306314   CIC_HUMAN
MINT-3306548   LMO7_HUMAN
MINT-3306606   VIR_HUMAN
MINT-3306625   FL2D_HUMAN
MINT-3306813   ZC3HD_HUMAN
MINT-3307270   PERQ2_HUMAN
MINT-3307331   LARP1_HUMAN
MINT-3307383   FNBP2_HUMAN
MINT-3307403   SMAG2_HUMAN
MINT-3307456   TERA_HUMAN
MINT-3307546   TPD52_HUMAN
MINT-3307735   MYCB2_HUMAN
MINT-3307756   MCM3_HUMAN
MINT-3307783   ASPP2_HUMAN
MINT-3307813   P3C2B_HUMAN
MINT-3307838   FRAP_HUMAN
MINT-3308034   PAK4_HUMAN
MINT-3308059   RPGF2_HUMAN
MINT-3308248   IQGA1_HUMAN
MINT-3308267   RPGP1_HUMAN
MINT-3308328   ATLA3_HUMAN
MINT-3308436   SRGP1_HUMAN
MINT-3308521   AFAD_HUMAN
MINT-3308685   LIPB1_HUMAN
MINT-3317863   TSC2_HUMAN
MINT-3317888   AKTS1_HUMAN
MINT-3317913   PTN3_HUMAN
MINT-3317930   YAP1_HUMAN
MINT-3317972   SH3B4_HUMAN
MINT-3317988   PSMD1_HUMAN
MINT-3318133   UBP8_HUMAN
MINT-3318149   CAND1_HUMAN
MINT-3318217   UBA1_HUMAN
MINT-3318321   PYR1_HUMAN
MINT-3318337   HDAC5_HUMAN
MINT-3318368   PRI2_HUMAN
MINT-3318428   PTBP1_HUMAN
MINT-3318458   HNRPU_HUMAN
MINT-3318488   DCP1A_HUMAN
MINT-3318520   DHX9_HUMAN
MINT-3318572   SRRM2_HUMAN
MINT-3318588   SYVC_HUMAN
MINT-3318610   SYIC_HUMAN
MINT-3318644   SYAC_HUMAN
MINT-3318676   EIF3A_HUMAN
MINT-3318692   IF4A1_HUMAN
MINT-3318708   KIF23_HUMAN
MINT-3318724   KLC3_HUMAN
MINT-3318808   FLNA_HUMAN
MINT-3318838   CING_HUMAN
MINT-3318854   AHNK_HUMAN
MINT-3318871   DESP_HUMAN
MINT-3318887   EZRI_HUMAN
MINT-3318904   SPTA2_HUMAN
MINT-3318920   SPTB2_HUMAN
MINT-3318937   VINC_HUMAN
MINT-3318960   ACTN4_HUMAN
MINT-3318976   PGAM1_HUMAN
MINT-3319004   PGK1_HUMAN
MINT-3319021   S27A2_HUMAN
MINT-3319127   PANK2_HUMAN
MINT-3319198   PURA1_HUMAN
MINT-3319239   CGL_HUMAN
MINT-3319281   TFR1_HUMAN
MINT-3319320   GRP75_HUMAN
MINT-3319337   HSP7C_HUMAN
MINT-3319393   FKBP4_HUMAN
MINT-3319394   HSP74_HUMAN
MINT-3319575   HS90B_HUMAN
MINT-3319592   XPO1_HUMAN
MINT-3319626   NFAC1_HUMAN
MINT-3319708   NUFP1_HUMAN
MINT-3319791   SET_HUMAN
MINT-3319822   CV028_HUMAN
MINT-3319865   TBCD4_HUMAN
MINT-3319899   KIBRA_HUMAN
MINT-3319917   RAI14_HUMAN
MINT-3319945   MVP_HUMAN
MINT-3319979   1433S_HUMAN
MINT-3319998   ESYT1_HUMAN
MINT-3320046   EDC3_HUMAN
MINT-3320063   MYCPP_HUMAN
MINT-3320079   CLH1_HUMAN
MINT-3320095   MYOF_HUMAN
MINT-3320159   SCAM2_HUMAN
MINT-7262288   KPCE_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein domain specific binding,
transcription factor binding		 melanosome anti-apoptosis,
signal transduction
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 184 FSVFYYEILNSPEKACSLAKT MAPK8 15071501
LTP
 - MOD_ProDKin_1
 - 14_3_3
0.08
 2O02 27.05%

Substrate: Amyloid-like protein 2 (Integral membrane protein)
Seq-ID: Q06481 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-60793   Z512B_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
serine-type endopeptidase inhibitor activity,
DNA binding,
identical protein binding		 plasma membrane,
integral to membrane,
nucleus		 G-protein coupled receptor protein signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 736 HGIVEVDPMLTPEERHLNKMQ MAPK8 14970211
LTP
0.92
 MOD_ProDKin_1
 - APP_amyloid
0.46
 - low

Substrate: Atrophin 1 (Transcription regulatory protein)
Seq-ID: P54259 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-2855063   TRIP6_HUMAN
MINT-2857363   CACB1_HUMAN
MINT-2857800   CRIP2_HUMAN
MINT-2858167   RERE_HUMAN
MINT-2858224   DVL2_HUMAN
MINT-2858628   EWS_HUMAN
MINT-2859138   G3P_HUMAN
MINT-2860743   MBP_HUMAN
MINT-2861721   K6PL_HUMAN
MINT-2861816   PLS1_HUMAN
MINT-2862031   PSA3_HUMAN
MINT-2863180   SIAH1_HUMAN
MINT-2864385   BAT2_HUMAN
MINT-2864594   BAT3_HUMAN
MINT-2864917   RBM10_HUMAN
MINT-2865111   NCK2_HUMAN
MINT-2866029   MTG8R_HUMAN
MINT-2868122   PSME3_HUMAN
MINT-2868323   BAIP2_HUMAN
MINT-2868607   SPAG5_HUMAN
MINT-2869261   WWP2_HUMAN
MINT-2870255   K0913_HUMAN
MINT-2871114   MYST4_HUMAN
MINT-2871399   PKCB1_HUMAN
MINT-2871705   ZN363_HUMAN
MINT-2871908   NOC2L_HUMAN
MINT-2874537   MA7D1_HUMAN
MINT-2875806   PERQ1_HUMAN
MINT-2877182   SYVN1_HUMAN
MINT-2878203   LENG8_HUMAN
MINT-2879232   STXB4_HUMAN
MINT-7974362   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein domain specific binding cytoplasm,
nucleus		 central nervous system development,
cell death
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 734 EPAEEYETPESPVPPARSPSP MAPK8 12812981
LTP
0.71
 MOD_ProDKin_1
 - Atrophin-1
0.94
 - medium

Substrate: BAD (Bcl2-antagonist of cell death (BAD) (Bcl-2 binding component 6) (Bcl- XL/Bcl-2 associated death promoter) (Bcl-2-like 8 protein))
Seq-ID: Q61337 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cytosol,
mitochondrial outer membrane		 induction of apoptosis by extracellular signals,
glucose homeostasis,
cytokine-mediated signaling pathway,
apoptosis,
positive regulation of B cell differentiation,
positive regulation of T cell differentiation,
glucose catabolic process,
cell proliferation,
regulation of caspase activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 128 EEDEGMEEELSPFRGRSRSAP MAPK8 12189144
LTP
0.92
 MOD_ProDKin_1
 - Bcl-2_BAD
0.86
 - medium
T 201 WDRNLGKGGSTPSQ        MAPK8 14967141
LTP
0.59
 MOD_ProDKin_1
 - Bcl-2_BAD
0.78
 - medium

Substrate: Bcl-2 (Apoptosis regulator Bcl-2)
Seq-ID: P10415 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-13660   B2L11_MOUSE
MINT-51440   MK01_HUMAN
MINT-51443   PP2AA_HUMAN
MINT-56637   FKBP8_HUMAN
MINT-56639   MK08_HUMAN
MINT-58237   CANB1_HUMAN
MINT-6629252   B2L11_HUMAN
MINT-7235965   ASPP2_HUMAN
MINT-7712827   BECN1_HUMAN
MINT-7717145   NAF1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein heterodimerization activity,
protein homodimerization activity,
transcription activator activity,
protease binding,
BH3 domain binding,
sequence-specific DNA binding		 nuclear membrane,
integral to membrane,
mitochondrial outer membrane,
endoplasmic reticulum membrane		 negative regulation of cellular pH reduction,
positive regulation of cell growth,
regulation of protein homodimerization activity,
response to toxin,
anti-apoptosis,
humoral immune response,
defense response to virus,
release of cytochrome c from mitochondria,
response to drug,
regulation of mitochondrial membrane potential,
regulation of mitochondrial membrane permeability,
regulation of protein heterodimerization activity,
response to cytokine stimulus,
apoptosis in response to endoplasmic reticulum stress,
neuron apoptosis,
female pregnancy,
negative regulation of neuron apoptosis,
response to iron ion,
activation of pro-apoptotic gene products,
negative regulation of mitochondrial depolarization,
response to nicotine,
protein polyubiquitination,
B cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 70 AASRDPVARTSPLQTPAAPGA MAPK8 10567572
LTP
1.00
 MOD_ProDKin_1
 PIN1 WW -
0.75
 --
S 87 APGAAAGPALSPVPPVVHLTL MAPK8 10567572
LTP
0.32
 MOD_ProDKin_1
 PIN1 WW -
0.43
 --

Substrate: Bcl-2 (Apoptosis regulator Bcl-2)
Seq-ID: P10417 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
MINT-15650   BID_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein heterodimerization activity,
protein phosphatase 2A binding,
transcription activator activity,
transcription factor binding		 microsome,
myelin sheath,
integral to membrane,
endoplasmic reticulum membrane,
nuclear membrane,
mitochondrial outer membrane,
cytosol		 branching involved in ureteric bud morphogenesis,
melanocyte differentiation,
response to hydrogen peroxide,
positive regulation of smooth muscle cell migration,
positive regulation of peptidyl-serine phosphorylation,
protein amino acid dephosphorylation,
regulation of mitochondrial membrane potential,
endoplasmic reticulum calcium ion homeostasis,
actin filament organization,
positive regulation of neuron maturation,
positive regulation of skeletal muscle fiber development,
B cell homeostasis,
ossification,
negative regulation of cell migration,
regulation of glycoprotein biosynthetic process,
organ growth,
pigment granule organization,
B cell lineage commitment,
cell-cell adhesion,
mesenchymal cell development,
regulation of protein stability,
response to UV-B,
spleen development,
CD8-positive, alpha-beta T cell lineage commitment,
focal adhesion assembly,
positive regulation of melanocyte differentiation,
positive regulation of cell proliferation,
homeostasis of number of cells within a tissue,
regulation of cell-matrix adhesion,
melanin metabolic process,
male gonad development,
response to protein stimulus,
negative regulation of cell growth,
thymus development,
anti-apoptosis,
cell aging,
G1/S transition of mitotic cell cycle,
release of cytochrome c from mitochondria,
regulation of mitochondrial membrane permeability,
response to gamma radiation,
peptidyl-serine phosphorylation,
negative regulation of ossification,
negative regulation of calcium ion transport into cytosol,
positive regulation of multicellular organism growth,
regulation of viral genome replication,
behavioral fear response,
neuron apoptosis,
regulation of protein localization,
cochlear nucleus development,
glomerulus development,
negative regulation of neuron apoptosis,
oxygen and reactive oxygen species metabolic process,
T cell homeostasis,
negative regulation of myeloid cell apoptosis,
axon regeneration,
developmental growth,
digestive tract morphogenesis,
negative regulation of mitotic cell cycle,
regulation of nitrogen utilization,
T cell differentiation in the thymus,
peptidyl-threonine phosphorylation,
lymphoid progenitor cell differentiation,
oocyte development,
ovarian follicle development,
renal system process,
ear development,
negative regulation of osteoblast proliferation,
gland morphogenesis,
hair follicle morphogenesis,
response to toxin,
cell growth,
response to drug,
positive regulation of catalytic activity,
post-embryonic development,
metanephros development,
response to cytokine stimulus,
negative regulation of retinal cell programmed cell death
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 70 AVHREMAARTSPLRPLVATAG MAPK8 11323415
LTP
0.08
 MOD_ProDKin_1
 - -
0.43
 - medium

Substrate: Bcl-2-like protein 11 (Unclassified)
Seq-ID: O43521-2 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
MINT-4980380   MCL1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein binding plasma membrane,
mitochondrion,
cytosol,
endomembrane system		 induction of apoptosis by extracellular signals,
activation of pro-apoptotic gene products
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 44 TSLQTEPQDRSPAPMSCDKST MAPK8 12591950
LTP
0.92
 MOD_ProDKin_1
 - -
0.87
 - medium

Substrate: Bcl-2-like protein 11 (Unclassified)
Seq-ID: O54918 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13660   BCL2_HUMAN
MINT-13878   B2CL1_HUMAN
MINT-17381   MCL1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
microtubule binding mitochondrion,
peripheral to membrane of membrane fraction,
membrane		 B cell apoptosis,
post-embryonic organ morphogenesis,
male gonad development,
thymus development,
kidney development,
in utero embryonic development,
positive regulation of apoptosis,
regulation of developmental pigmentation,
tube formation,
B cell homeostasis,
cell-matrix adhesion,
regulation of organ growth,
spermatogenesis,
T cell homeostasis,
mammary gland development,
myeloid cell homeostasis,
odontogenesis of dentine-containing tooth,
developmental pigmentation,
spleen development,
ear development
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 55 DGEGDRCPHGSPQGPLAPPAS MAPK8 12818176
LTP
0.29
 MOD_ProDKin_1
 - -
0.95
 - medium
S 65 SPQGPLAPPASPGPFATRSPL MAPK8 12818176
LTP
0.94
 MOD_ProDKin_1
 PIN1 WW -
0.80
 - medium
S 73 PASPGPFATRSPLFIFVRRSS MAPK8 12818176
LTP
1.00
 MOD_ProDKin_1
 - -
0.50
 - medium

Substrate: BCL2L1 (identical protein binding)
Seq-ID: Q07817 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-13878   B2L11_MOUSE
MINT-14699   BAD_HUMAN
MINT-14946   PSN2_HUMAN
MINT-16205   PSN1_HUMAN
MINT-16786   BID_MOUSE
MINT-56640   MK08_HUMAN
MINT-56641   FKBP8_HUMAN
MINT-1955144   ABL1_HUMAN
MINT-7014585   BECN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
identical protein binding nuclear membrane,
integral to membrane,
mitochondrial outer membrane		 release of cytochrome c from mitochondria,
regulation of mitochondrial membrane potential,
regulation of mitochondrial membrane permeability,
negative regulation of survival gene product expression,
response to cytokine stimulus
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 47 APEGTESEMETPSAINGNPSW MAPK8 10617621
LTP
0.00
 MOD_ProDKin_1
 - -
0.78
 --
S 62 NGNPSWHLADSPAVNGATGHS MAPK8 12633850
LTP
0.31
 MOD_ProDKin_1
 - -
0.54
 --
T 115 FSDLTSQLHITPGTAYQSFEQ MAPK8 10617621
LTP
1.00
 MOD_ProDKin_1
 - BCL
0.31
 3FDL 34.93%

Substrate: c-Jun (c-Jun (Transcription factor AP-1))
Seq-ID: P05412 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14077   DDX21_HUMAN
MINT-68803   VE7_HPV16
MINT-68804   FOS_HUMAN
MINT-6628041   ATF2_HUMAN
MINT-6628056   CITE1_HUMAN
MINT-7148314   MK08_HUMAN
MINT-7148323   MK09_HUMAN
MINT-7148332   MK10_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription repressor activity,
R-SMAD binding,
RNA polymerase II transcription factor activity, enhancer binding,
Rho GTPase activator activity,
transcription coactivator activity,
promoter binding		 SMAD protein nuclear translocation,
positive regulation by host of viral transcription,
SMAD protein signal transduction,
negative regulation of DNA binding,
transforming growth factor beta receptor signaling pathway,
positive regulation of transcription from RNA polymerase II promoter
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 63 LRAKNSDLLTSPDVGLLKLAS MAPK8 8137421
LTP
1.00
 MOD_ProDKin_1
 PIN1 WW Jun
0.43
 --
S 63 LRAKNSDLLTSPDVGLLKLAS MAPK8 11948398
LTP
1.00
 MOD_ProDKin_1
 PIN1 WW Jun
0.43
 --
S 73 SPDVGLLKLASPELERLIIQS MAPK8 8137421
LTP
1.00
 MOD_ProDKin_1
 PIN1 WW Jun
0.34
 --

Substrate: Cyclic-AMP-dependent transcription factor ATF-2 (Transcription factor)
Seq-ID: P15336 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-1788416   JUNB_HUMAN
MINT-6628041   JUN_HUMAN
MINT-6628046   CITE1_HUMAN
MINT-6699865   I2BP1_HUMAN
MINT-7555703   HDAC4_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
sequence-specific DNA binding,
protein dimerization activity,
RNA polymerase II transcription factor activity,
transcription coactivator activity,
zinc ion binding,
sequence-specific DNA binding transcription factor activity		 nucleoplasm transcription,
regulation of transcription, DNA-dependent
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 53 DSVIVADQTPTPTRFLKNCEE MAPK8 11971971
LTP
0.00
 MOD_ProDKin_1
 - -
0.51
 --
T 53 DSVIVADQTPTPTRFLKNCEE MAPK8 11896587
LTP
0.00
 MOD_ProDKin_1
 - -
0.51
 --

Substrate: Cytokeratin 8 (keratin, type II cytoskeletal 8 (cytokeratin 8) (K8) (CK8) (from PhosphoBase))
Seq-ID: P05787 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-51056   RAF1_HUMAN
MINT-61555   GRB2_HUMAN
MINT-2984733   ZO1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
structural molecule activity,
protein binding		 cytoplasm,
keratin filament		 cytoskeleton organization,
interspecies interaction between organisms
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 74 TAVTVNQSLLSPLVLEVDPNI MAPK8 11781324
LTP
0.18
 MOD_ProDKin_1
 - -
0.28
 - low

Substrate: ETS domain protein Elk-3 (Transcription factor)
Seq-ID: P41971 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
sequence-specific DNA binding transcription factor activity nucleus transcription,
angiogenesis,
regulation of transcription, DNA-dependent,
wound healing
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 359 LPSIHFWSSLSPVAPLSPARL MAPK8 11042694
LTP
1.00
 MOD_ProDKin_1
 - -
0.26
 - medium
S 365 WSSLSPVAPLSPARLQGPNTL MAPK8 11042694
LTP
0.75
 MOD_ProDKin_1
 - -
0.39
 - medium

Substrate: Forkhead box protein O4 (Putative fork head domain transcription factor AFX1 (Forkhead box protein O4))
Seq-ID: P98177 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
MINT-7299691   OGT1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
enzyme binding,
transcription factor binding,
sequence-specific DNA binding transcription factor activity		 cytosol,
nucleus		 transcription from RNA polymerase II promoter,
negative regulation of angiogenesis,
G1 phase of mitotic cell cycle,
negative regulation of cell proliferation,
cell cycle arrest,
negative regulation of smooth muscle cell differentiation,
muscle organ development,
regulation of transcription, DNA-dependent,
cell differentiation,
insulin receptor signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 451 ASAPIPKALGTPVLTPPTEAA MAPK8 15538382
LTP
0.01
 MOD_ProDKin_1
 - -
0.68
 - medium
T 455 IPKALGTPVLTPPTEAASQDR MAPK8 15538382
LTP
0.49
 MOD_ProDKin_1
 - -
0.78
 - medium

Substrate: Histone H3.3 (DNA binding protein)
Seq-ID: P84245 [Rattus norvegicus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA binding nucleus,
nucleosome		 brain development,
nucleosome assembly,
response to hormone stimulus
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 29 KQLATKAARKSAPSTGGVKKP MAPK8 11278789
LTP
0.70
 - -
0.70
 - medium

Substrate: hnRNPK (Ribonucleoprotein)
Seq-ID: P61978 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-2859758   PCBP1_HUMAN
MINT-3296872   1433Z_HUMAN
MINT-6803834   ANM1_HUMAN
MINT-6803896   ANM3_HUMAN
MINT-7035260   SRC_HUMAN
MINT-7974306   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA binding,
RNA binding,
protein binding		 spliceosomal complex,
cytoplasm,
nucleoplasm,
heterogeneous nuclear ribonucleoprotein complex		 mRNA processing,
signal transduction,
interspecies interaction between organisms,
RNA splicing
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 353 ETWDSAIDTWSPSEWQMAYEP MAPK8 11259409
LTP
0.37
 MOD_ProDKin_1
 - -
0.57
 --

Substrate: ITCH (protein binding, ubiquitin-protein ligase activity)
Seq-ID: Q8C863 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-7040747   RBP1_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein binding,
ubiquitin-protein ligase activity		 plasma membrane,
membrane fraction,
cytoplasmic vesicle,
nucleus,
cell cortex		 positive regulation of protein catabolic process,
negative regulation of apoptosis,
apoptosis,
positive regulation of T cell anergy,
negative regulation of alpha-beta T cell proliferation,
negative regulation of defense response to virus,
innate immune response,
protein K48-linked ubiquitination,
protein ubiquitination involved in ubiquitin-dependent protein catabolic process,
protein K63-linked ubiquitination,
protein K29-linked ubiquitination,
protein polyubiquitination,
response to virus
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 199 GENKRANGNNSPSLSNGGFKP MAPK8 16446428
LTP
0.40
 MOD_ProDKin_1
 - -
0.88
 - medium
T 222 PPRPSRPPPPTPRRPASVNGS MAPK8 16446428
LTP
0.50
 MOD_ProDKin_1
 - -
0.98
 - medium
S 232 TPRRPASVNGSPSTNSDSDGS MAPK8 16446428
LTP
0.39
 MOD_ProDKin_1
 - -
0.96
 - medium

Substrate: jdp2 (protein dimerization activity, sequence-specific DNA binding)
Seq-ID: ENSMUSP00000043430 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription repressor activity,
sequence-specific DNA binding		 nucleus transcription,
negative regulation of transcription from RNA polymerase II promoter
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 148 TCIVRTDSVRTPESEGNPLLE MAPK8 11602244
LTP
1.00
 MOD_ProDKin_1
 - -
0.61
 - medium

Substrate: JNK-interacting protein 1 (Transcription factor)
Seq-ID: Q9UQF2 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-14547   A4_HUMAN
MINT-45956   ITB2_HUMAN
MINT-45957   ITB3_HUMAN
MINT-45958   ITB7_HUMAN
MINT-45971   A4_MOUSE
MINT-63239   RECQ5_HUMAN
MINT-74572   EGFR_HUMAN
MINT-74575   ERBB2_HUMAN
MINT-6629291   M3K7_HUMAN
MINT-6629296   MP2K7_HUMAN
MINT-6629301   MK08_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein kinase inhibitor activity,
MAP-kinase scaffold activity,
kinesin binding		 nucleus,
perinuclear region of cytoplasm		 vesicle-mediated transport
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 103 QMDLIDATGDTPGAEDDEEDD MAPK8 12756254
LTP
0.11
 MOD_ProDKin_1
 - -
0.93
 - low

Substrate: PPARG (Transcription factor)
Seq-ID: P37231 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
specific transcriptional repressor activity,
transcription activator binding,
transcription activator activity,
arachidonic acid binding,
zinc ion binding,
promoter binding,
sequence-specific DNA binding transcription factor activity,
drug binding,
retinoid X receptor binding,
prostaglandin receptor activity,
steroid hormone receptor activity		 cytosol,
nucleus		 negative regulation of gene-specific transcription from RNA polymerase II promoter,
positive regulation of gene-specific transcription from RNA polymerase II promoter,
regulation of blood pressure,
epithelial cell differentiation,
white fat cell differentiation,
lipoprotein transport,
negative regulation of receptor biosynthetic process,
negative regulation of sequestering of triglyceride,
positive regulation of transcription factor activity,
activation of caspase activity,
placenta development,
cell fate commitment,
cell maturation,
innate immune response,
lipid homeostasis,
negative regulation of macrophage derived foam cell differentiation,
low-density lipoprotein receptor biosynthetic process,
monocyte differentiation,
regulation of cholesterol transporter activity,
response to lipid,
long-chain fatty acid transport,
positive regulation of fat cell differentiation,
response to low-density lipoprotein stimulus,
cellular response to insulin stimulus,
negative regulation of cholesterol storage,
induction of apoptosis,
transcription,
glucose homeostasis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 112 YQSAIKVEPASPPYYSEKTQL MAPK8 9030579
LTP
1.00
 MOD_ProDKin_1
 - -
0.37
 - medium

Substrate: SFN (protein binding, protein kinase C inhibitor activity)
Seq-ID: P31947 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14116   GCR_HUMAN
MINT-15829   CDC2_HUMAN
MINT-17572   BAX_HUMAN
MINT-17710   TSC2_HUMAN
MINT-51069   MPIP2_HUMAN
MINT-66103   BAD_HUMAN
MINT-66436   PKHF2_HUMAN
MINT-66797   PLK4_HUMAN
MINT-2983605   KAP2_HUMAN
MINT-3319979   1433Z_HUMAN
MINT-3974750   ABLM1_HUMAN
MINT-3974770   SHRM1_HUMAN
MINT-3974833   RHGBA_HUMAN
MINT-3974844   RHG21_HUMAN
MINT-3974900   ARHGH_HUMAN
MINT-3974919   ARHGG_HUMAN
MINT-3974941   BCAR1_HUMAN
MINT-3974952   CING_HUMAN
MINT-3974974   GAN_HUMAN
MINT-3974985   GRB7_HUMAN
MINT-3975007   LAD1_HUMAN
MINT-3975066   MARK1_HUMAN
MINT-3975077   MARK2_HUMAN
MINT-3975099   PAK4_HUMAN
MINT-3975110   PAR3L_HUMAN
MINT-3975121   PARD3_HUMAN
MINT-3975132   PKP2_HUMAN
MINT-3975156   PKP3_HUMAN
MINT-3975167   LIPB1_HUMAN
MINT-3975178   LIPB2_HUMAN
MINT-3975189   PTN3_HUMAN
MINT-3975200   RGAP1_HUMAN
MINT-3975242   RHPN2_HUMAN
MINT-3975290   SHRM3_HUMAN
MINT-3975301   SI1L1_HUMAN
MINT-3975312   SI1L3_HUMAN
MINT-3975342   ZO2_HUMAN
MINT-3975353   APC_HUMAN
MINT-3975364   ARAF_HUMAN
MINT-3975375   BRAF_HUMAN
MINT-3975386   RAF1_HUMAN
MINT-3975397   CSK21_HUMAN
MINT-3975408   DTX2_HUMAN
MINT-3975419   DYR1A_HUMAN
MINT-3975430   IRS1_HUMAN
MINT-3975441   IRS2_HUMAN
MINT-3975452   M3K2_HUMAN
MINT-3975485   SIN1_HUMAN
MINT-3975507   OSBL3_HUMAN
MINT-3975518   P3C2B_HUMAN
MINT-3975529   PI4KB_HUMAN
MINT-3975555   PPR3D_HUMAN
MINT-3975592   PTN2_HUMAN
MINT-3975603   SASH1_HUMAN
MINT-3975614   SH23A_HUMAN
MINT-3975625   SH3B4_HUMAN
MINT-3975636   SHCBP_HUMAN
MINT-3975647   ST5_HUMAN
MINT-3975686   TNK1_HUMAN
MINT-3975697   JUB_HUMAN
MINT-3975708   KIF23_HUMAN
MINT-3975719   MARK3_HUMAN
MINT-3975741   WEE1_HUMAN
MINT-3975752   MLTK_HUMAN
MINT-3975807   UBP8_HUMAN
MINT-3975818   HDAC4_HUMAN
MINT-3975829   HDAC7_HUMAN
MINT-3975864   ZN638_HUMAN
MINT-3975875   MYCB2_HUMAN
MINT-3975886   TRI32_HUMAN
MINT-3975897   KINH_HUMAN
MINT-3975908   KLC2_HUMAN
MINT-3976028   KLC1_HUMAN
MINT-3976039   CYH2_HUMAN
MINT-3976105   SYNJ2_HUMAN
MINT-3976116   SF13A_HUMAN
MINT-3976127   HNRPU_HUMAN
MINT-3976138   SRRM2_HUMAN
MINT-3976149   ISCU_HUMAN
MINT-3976160   ANS1A_HUMAN
MINT-3976193   LMO7_HUMAN
MINT-3976316   MPRIP_HUMAN
MINT-3976327   SG223_HUMAN
MINT-3976338   EDC3_HUMAN
MINT-3976408   REEP4_HUMAN
MINT-3976446   UBP43_HUMAN
MINT-3976465   F117B_HUMAN
MINT-3976484   FA53B_HUMAN
MINT-3976506   PACS2_HUMAN
MINT-3976629   REEP3_HUMAN
MINT-3976640   PDZ11_HUMAN
MINT-3976660   RICTR_HUMAN
MINT-3976701   ERRFI_HUMAN
MINT-7711943   P53_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein domain specific binding,
protein kinase C inhibitor activity		 cytoplasm,
extracellular space,
nucleus		 negative regulation of caspase activity,
release of cytochrome c from mitochondria,
signal transduction,
negative regulation of protein kinase activity,
DNA damage response, signal transduction resulting in induction of apoptosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 186 FSVFHYEIANSPEEAISLAKT MAPK8 15071501
LTP
0.79
 MOD_ProDKin_1
 - 14_3_3
0.25
 1YWT 17.21%

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