Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

Substrate:

cAMP-dependent protein kinase, alpha-catalytic subunit (cAMP-dependent protein kinase)

Seq-ID:

P05132 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-4051315 PDE3A_MOUSE
MINT-7211789 LIPS_RAT

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cAMP-dependent protein kinase activity, ATP binding	plasma membrane, mitochondrion, neuromuscular junction, cytosol, nucleoplasm	mesoderm formation, positive regulation of protein export from nucleus, protein amino acid autophosphorylation, cellular response to parathyroid hormone stimulus

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	198	FAKRVKGRTWTLCGTPEYLAP	PDK-1	12372837	LTP	0.95		-	S_TKc	0.09	1RDQ	47.26%

Substrate:

Integrin beta 3 (Platelet membrane glycoprotein IIIa)

Seq-ID:

P05106 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-25081   ITAV_HUMAN
MINT-45900   EPS8_HUMAN
MINT-45905   RBGP1_HUMAN
MINT-45913   GULP1_HUMAN
MINT-45916   RGS12_HUMAN
MINT-45923   DAB1_MOUSE
MINT-45928   DAB2_MOUSE
MINT-45939   IRS1_RAT
MINT-45952   TLN1_MOUSE
MINT-45957   JIP1_HUMAN
MINT-45960   LIN10_CAEEL
MINT-61480   TENC1_HUMAN
MINT-61568   DOK1_MOUSE
MINT-61569   NUMB_MOUSE
MINT-1795026   TLN1_HUMAN
MINT-6794817   PTN1_HUMAN
MINT-7384376   SRC_MOUSE
MINT-7384444   LYN_HUMAN
MINT-7384460   YES_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
receptor activity, vascular endothelial growth factor receptor 2 binding, identical protein binding, platelet-derived growth factor receptor binding, cell adhesion molecule binding	integrin complex, alphav-beta3 integrin-vitronectin complex, platelet alpha granule membrane	positive regulation of peptidyl-tyrosine phosphorylation, positive regulation of endothelial cell proliferation, regulation of bone resorption, blood coagulation, negative regulation of lipid transport, tube development, activation of protein kinase activity, integrin-mediated signaling pathway, positive regulation of vascular endothelial growth factor receptor signaling pathway, negative regulation of lipid storage, negative regulation of macrophage derived foam cell differentiation, cell-matrix adhesion, interspecies interaction between organisms, smooth muscle cell migration, negative regulation of lipoprotein metabolic process, angiogenesis involved in wound healing, positive regulation of endothelial cell migration, negative regulation of low-density lipoprotein receptor biosynthetic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	777	TANNPLYKEATSTFTNITYRG	PDK-1	10896934	LTP	1.00		-	Integrin_b_cyt	0.27	-	-
T	779	NNPLYKEATSTFTNITYRGT	PDK-1	10896934	LTP	1.00		-	Integrin_b_cyt	0.27	-	-

Substrate:

MAP2K1 (Dual specificity mitogen-activated protein kinase kinase 1 (EC 2.7.1.-) (MAP kinase kinase 1) (MAPKK 1) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK1))

Seq-ID:

Q02750 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-16002   KSR1_MOUSE
MINT-3391583   M3K1_HUMAN
MINT-4300484   MK01_HUMAN
MINT-7014370   RAF1_HUMAN
MINT-7014390   MK03_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, MAP kinase kinase activity, ATP binding, protein tyrosine kinase activity	cytosol	senescence, negative regulation of cell proliferation, cell cycle arrest, chemotaxis, Ras protein signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	222	SGQLIDSMANSFVGTRSYMSP	PDK-1	15175348	LTP	1.00		-	S_TKc	0.28	-	-

Substrate:

MAP2K2 ( Ser/Thr protein kinase)

Seq-ID:

P36507 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-17529 KSR1_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, ATP binding, protein tyrosine kinase activity, protein binding	extracellular region, cytosol	protein amino acid phosphorylation, Ras protein signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	226	SGQLIDSMANSFVGTRSYMAP	PDK-1	15175348	LTP	1.00		-	S_TKc	0.28	-	-

Substrate:

MAP3K5 (Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.1. -) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1)

Seq-ID:

Q99683 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-16168   M3K3_HUMAN
MINT-18083   M3K2_HUMAN
MINT-18459   DAB2P_HUMAN
MINT-3391607   MP2K7_HUMAN
MINT-7263196   ARRB2_HUMAN
MINT-7263254   ARRB1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, protein homodimerization activity, ATP binding, caspase activator activity, MAP kinase kinase kinase activity		induction of apoptosis by extracellular signals, apoptosis, activation of JUN kinase activity, interspecies interaction between organisms

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	838	RLAGINPCTETFTGTLQYMAP	PDK-1	15755722	LTP	1.00		-	S_TKc	0.24	2CLQ	86.30%

Substrate:

PDK1 (3-phosphoinositide dependent protein kinase-1; serine/threonine kinase)

Seq-ID:

O15530 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13835   AKT1_HUMAN
MINT-14377   KS6B1_HUMAN
MINT-15996   1433F_HUMAN
MINT-16333   1433T_HUMAN
MINT-17466   FRAP_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
3-phosphoinositide-dependent protein kinase activity, ATP binding, protein binding	plasma membrane, cytosol	intracellular signaling pathway, actin cytoskeleton organization, cellular response to insulin stimulus, positive regulation of establishment of protein localization in plasma membrane, negative regulation of protein kinase activity, peptidyl-threonine phosphorylation, activation of protein kinase B activity

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	25	QSSVVLCSCPSPSMVRTQTES	PDK-1	10455013	LTP	0.91	-	-	0.53	-	-
S	241	SPESKQARANSFVGTAQYVSP	PDK-1	10455013	LTP	1.00	YWHAH 14-3-3; YWHAQ 14-3-3	S_TKc	0.25	1UU3	123.77%
S	393	FGCMQVSSSSSSHSLSASDTG	PDK-1	10455013	LTP	0.93	-	-	0.43	-	-
S	396	MQVSSSSSSHSLSASDTGLPQ	PDK-1	10455013	LTP	0.60	-	-	0.53	-	-
S	410	SDTGLPQRSGSNIEQYIHDLD	PDK-1	10455013	LTP	0.72	-	-	0.49	1W1D	31.15%
T	513	ELRPEAKNFKTFFVHTPNRTY	PDK-1	16780920	LTP	1.00	-	-	0.29	1W1D	13.70%

Substrate:

PKB-alpha (RAC-alpha serine/threonine kinase (EC 2.7.1.-) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT))

Seq-ID:

P31749 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13835   PDPK1_HUMAN
MINT-15213   KS6B1_HUMAN
MINT-16737   FRAP_HUMAN
MINT-17680   CDN1B_HUMAN
MINT-74931   PP2AA_HUMAN
MINT-3379039   TOPB1_HUMAN
MINT-4820691   CASP3_HUMAN
MINT-6175251   STK4_HUMAN
MINT-6742762   TERT_HUMAN
MINT-6823537   MDM2_HUMAN
MINT-7014449   RAF1_HUMAN
MINT-7146767   PLCG1_HUMAN
MINT-7232672   KPCZ_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphatidylinositol-3,4-bisphosphate binding, protein serine/threonine kinase activity, phosphatidylinositol-3,4,5-trisphosphate binding, identical protein binding, nitric-oxide synthase regulator activity, ATP binding, enzyme binding	plasma membrane, cytosol, nucleoplasm	response to UV-A, positive regulation of cell growth, regulation of neuron projection development, positive regulation of cyclin-dependent protein kinase activity involved in G1/S, glycogen biosynthetic process, response to heat, negative regulation of fatty acid beta-oxidation, insulin-like growth factor receptor signaling pathway, peptidyl-serine phosphorylation, regulation of translation, protein amino acid autophosphorylation, positive regulation of nitric-oxide synthase activity, nitric oxide biosynthetic process, positive regulation of fat cell differentiation, positive regulation of glycogen biosynthetic process, positive regulation of lipid biosynthetic process, activation of pro-apoptotic gene products, negative regulation of plasma membrane long-chain fatty acid transport, positive regulation of establishment of protein localization in plasma membrane, insulin receptor signaling pathway, positive regulation of glucose import, negative regulation of protein kinase activity, response to fluid shear stress, activation-induced cell death of T cells, protein import into nucleus, translocation, G-protein coupled receptor protein signaling pathway, positive regulation of nitric oxide biosynthetic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	308	EGIKDGATMKTFCGTPEYLAP	PDK-1	9868760	LTP	1.00	-	S_TKc	0.22	3CQU	71.92%
T	308	EGIKDGATMKTFCGTPEYLAP	PDK-1	15718470	LTP	1.00	-	S_TKc	0.22	3CQU	71.92%
S	473	SERRPHFPQFSYSASGTA	PDK-1	10226025	LTP	0.95	-	S_TK_X	0.52	3CQU	51.66%

Substrate:

PKB-alpha (RAC-alpha serine/threonine kinase (EC 2.7.1.-) (RAC-PK-alpha) (Protein kinase B) (PKB) (C-AKT))

Seq-ID:

P31750 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-4049581   PDE3A_MOUSE
MINT-6175057   STK4_HUMAN
MINT-6793722   PTN1_HUMAN
MINT-6978911   HS90A_MOUSE
MINT-6978941   UBIQ_MOUSE

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, ATP binding	plasma membrane, spindle, cytosol, lamellipodium, nucleus	response to food, glycogen cell development involved in embryonic placenta development, protein ubiquitination, regulation of neuron projection development, maternal placenta development, glycogen biosynthetic process, apoptotic mitochondrial changes, germ cell development, inflammatory response, insulin-like growth factor receptor signaling pathway, peptidyl-serine phosphorylation, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, anagen, positive regulation of sodium ion transport, regulation of translation, labyrinthine layer blood vessel development, protein catabolic process, protein kinase B signaling cascade, glucose transport, insulin receptor signaling pathway, regulation of survival gene product expression

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	308	EGIKDGATMKTFCGTPEYLAP	PDK-1	12682057	LTP	1.00		-	S_TKc	0.22	-	medium
T	308	EGIKDGATMKTFCGTPEYLAP	PDK-1	19047061	LTP	1.00		-	S_TKc	0.22	-	medium

Substrate:

PKB-beta (RAC-beta serine/threonine protein kinase (EC 2.7.1.-) (RAC-PK-beta) (Protein kinase Akt-2) (Protein kinase B, beta) (PKB beta))

Seq-ID:

P31751 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-4820707 CASP3_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, ATP binding, protein binding	cytosol, nucleus	positive regulation of fatty acid beta-oxidation, positive regulation of glycogen biosynthetic process, negative regulation of plasma membrane long-chain fatty acid transport, insulin receptor signaling pathway, positive regulation of glucose import

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	309	EGISDGATMKTFCGTPEYLAP	PDK-1	9512493	LTP	1.00		-	S_TKc	0.23	1O6K	47.26%

Substrate:

PKB-gamma (RAC-gamma serine/threonine protein kinase (EC 2.7.1.-) (RAC-PK-gamma) (Protein kinase Akt-3) (Protein kinase B, gamma) (PKB gamma) (STK-2))

Seq-ID:

Q9Y243 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-4820732 CASP3_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, ATP binding, protein binding	cytoplasm, membrane	protein amino acid phosphorylation, signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	305	EGITDAATMKTFCGTPEYLAP	PDK-1	9512493	LTP	1.00		-	S_TKc	0.19	-	medium

Substrate:

PKC delta (Protein kinase C, delta)

Seq-ID:

P09215 [Rattus norvegicus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein kinase binding, metal ion binding, calcium-independent protein kinase C activity, ATP binding	membrane fraction, mitochondrion, nucleus, membrane	intracellular signaling pathway, positive regulation of MAPKKK cascade, cellular response to glucose starvation, response to amino acid stimulus, response to hypoxia, response to hydrogen peroxide, response to organic cyclic substance, aging, response to drug, response to heat, response to glucose stimulus, protein amino acid autophosphorylation, collagen metabolic process, aspartate transport, response to mechanical stimulus, cellular response to insulin stimulus, induction of apoptosis, positive regulation of glucose import, positive regulation of MAP kinase activity, response to ethanol

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	505	ENIFGENRASTFCGTPDYIAP	PDK-1	9748166	LTP	1.00		-	S_TKc	0.14	-	medium

Substrate:

PKC delta (Protein kinase C, delta)

Seq-ID:

Q05655 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-62336   CDCP1_HUMAN
MINT-62340   SRC_HUMAN
MINT-1955124   ABL1_HUMAN
MINT-3973536   NCF1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
enzyme activator activity, protein C-terminus binding, metal ion binding, insulin receptor substrate binding, calcium-independent protein kinase C activity, ATP binding, enzyme binding	plasma membrane, cytosol, nucleus, endoplasmic reticulum	protein stabilization, protein amino acid phosphorylation, senescence, negative regulation of insulin receptor signaling pathway, negative regulation of peptidyl-tyrosine phosphorylation, signal transduction, regulation of receptor activity, negative regulation of protein binding

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	507	ENIFGESRASTFCGTPDYIAP	PDK-1	9748166	LTP	1.00		-	S_TKc	0.14	-	-

Substrate:

PKC epsilon (Serine/threonine kinase)

Seq-ID:

Q02156 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-2833238   BRAF_HUMAN
MINT-2833275   KPCA_HUMAN
MINT-2833498   KS6A2_HUMAN
MINT-7262288   1433Z_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
enzyme activator activity, metal ion binding, ATP binding, enzyme binding, signal transducer activity	plasma membrane, endoplasmic reticulum	protein amino acid phosphorylation, induction of apoptosis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	566	EGILNGVTTTTFCGTPDYIAP	PDK-1	11964154	LTP	1.00		-	S_TKc	0.14	-	medium

Substrate:

PKC zeta (Protein kinase C, zeta)

Seq-ID:

Q05513 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-50084   TF65_HUMAN
MINT-4085674   PAR6A_HUMAN
MINT-4085708   JAM1_HUMAN
MINT-4298316   NUMB_DROME
MINT-7232672   AKT1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein kinase C activity, insulin receptor substrate binding, ATP binding, zinc ion binding	endosome, cytosol	negative regulation of insulin receptor signaling pathway, anti-apoptosis, negative regulation of peptidyl-tyrosine phosphorylation, signal transduction, peptidyl-serine phosphorylation, negative regulation of protein complex assembly

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	410	EGLGPGDTTSTFCGTPNYIAP	PDK-1	9748166	LTP	0.98		-	S_TKc	0.31	-	medium
T	410	EGLGPGDTTSTFCGTPNYIAP	PDK-1	10075713	LTP	0.98		-	S_TKc	0.31	-	medium

Substrate:

PKC-like 1 (Protein Kinase N)

Seq-ID:

Q16512 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
histone binding, protein kinase C binding, protein kinase C activity, ligand-dependent nuclear receptor transcription coactivator activity, androgen receptor binding, histone kinase activity (H3-T11 specific), GTP-Rho binding, chromatin binding, histone deacetylase binding, Rac GTPase binding, ATP binding	plasma membrane, endosome, nucleus	transcription, activation of JUN kinase activity, regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	774	EGMGYGDRTSTFCGTPEFLAP	PDK-1	10792047	LTP	1.00		-	S_TKc	0.23	-	medium

Substrate:

Protein kinase N2 (Serine/threonine kinase)

Seq-ID:

O08874 [Rattus norvegicus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein kinase C activity, histone deacetylase binding, ATP binding	cytoplasm	protein amino acid phosphorylation, signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	952	EDVSNFDDEFTSEAPILTPPR	PDK-1	10753910	LTP	1.00		-	S_TK_X	0.54	-	low

Substrate:

Protein kinase N2 (Serine/threonine kinase)

Seq-ID:

Q16513 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-73310   PTN13_HUMAN
MINT-3390627   PDK1_HUMAN
MINT-7136634   NCK2_HUMAN
MINT-7710106   HDAC5_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein kinase C activity, histone deacetylase binding, ATP binding	cytoplasm	protein amino acid phosphorylation, signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	816	EGMGYGDRTSTFCGTPEFLAP	PDK-1	10753910	LTP	0.97		-	S_TKc	0.22	-	medium

Substrate:

Ribosomal protein S6 kinase 1 (p70 S6 kinase)

Seq-ID:

P23443 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14377   PDPK1_HUMAN
MINT-14953   4EBP1_MOUSE
MINT-15213   AKT1_HUMAN
MINT-15292   CDC42_HUMAN
MINT-51122   COASY_HUMAN
MINT-74872   TAU_HUMAN
MINT-74874   TAU_HUMAN
MINT-3390512   PDK1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
ATP binding, protein kinase activity, protein binding	cell junction, cytoplasm, cytosol, synapse, mitochondrial outer membrane, synaptosome, nucleus	TOR signaling cascade, negative regulation of apoptosis, positive regulation of mitotic cell cycle, apoptosis, G1/S transition of mitotic cell cycle, phosphoinositide-mediated signaling, positive regulation of translational initiation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	252	ESIHDGTVTHTFCGTIEYMAP	PDK-1	9445476	LTP	0.96	-	S_TKc	0.15	-	low
T	412	ESANQVFLGFTYVAPSVLESV	PDK-1	15388791	LTP	0.94	-	S_TK_X	0.23	-	low
T	412	ESANQVFLGFTYVAPSVLESV	PDK-1	12183455	LTP	0.94	-	S_TK_X	0.23	-	low
S	427	SVLESVKEKFSFEPKIRSPRR	PDK-1	9271440	LTP	0.37	-	-	0.40	-	low

Substrate:

S6K-alpha 1 (Ribosomal protein S6 kinase alpha 1)

Seq-ID:

Q15418 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-17060   EF2K_HUMAN
MINT-19367   1433B_HUMAN
MINT-2793474   IF4B_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, protein serine/threonine kinase activity, ATP binding, protein binding	cytosol, nucleoplasm	protein amino acid phosphorylation, intracellular protein kinase cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	221	EAIDHEKKAYSFCGTVEYMAP	PDK-1	10480933	LTP	1.00		-	S_TKc	0.16	-	-

Substrate:

S6K-alpha 3 (Serine/threonine kinase)

Seq-ID:

P18654 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-68551 SHAN1_RAT
MINT-68552 SHAN3_RAT

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, protein serine/threonine kinase activity, ATP binding		protein amino acid phosphorylation, intracellular protein kinase cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	577	QLRAENGLLMTPCYTANFVAP	PDK-1	10480933	LTP	1.00		-	S_TKc	0.12	2QR8	31.51%

Substrate:

Ser/thr-protein kinase Sgk3 (Serine/threonine kinase)

Seq-ID:

Q96BR1 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-2881316 ITCH_HUMAN
MINT-2881402 PDK1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, phosphoinositide binding, ATP binding, protein binding	early endosome, cytoplasmic membrane-bounded vesicle	protein amino acid phosphorylation, response to stress, cell communication

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	320	EGIAISDTTTTFCGTPEYLAP	PDK-1	10548550	LTP	-		-	S_TKc	0.16	-	low

Substrate:

Serine/threonine-protein kinase PAK 1 (Ser/Thr protein kinase family)

Seq-ID:

Q13153 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-14030   CDC42_HUMAN
MINT-61476   NCK1_HUMAN
MINT-1771821   CD11B_HUMAN
MINT-1953519   GIT1_HUMAN
MINT-1953555   GIT2_HUMAN
MINT-3389399   RAF1_HUMAN
MINT-6541935   SRC8_HUMAN
MINT-7211888   SH3K1_HUMAN
MINT-7212697   ARHG7_HUMAN
MINT-7217644   RAC1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, collagen binding, ATP binding	focal adhesion, cytosol, Golgi apparatus	ER-nucleus signaling pathway, apoptosis, positive regulation of JUN kinase activity, protein amino acid autophosphorylation, cytoskeleton organization

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	423	QITPEQSKRSTMVGTPYWMAP	PDK-1	10995762	LTP	1.00		-	S_TKc	0.37	3FXZ	72.60%

Substrate:

Serine/threonine-protein kinase Sgk1 (Serine/threonine kinase)

Seq-ID:

O00141 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-56642 CREB1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, ATP binding, protein binding	plasma membrane, nucleus, endoplasmic reticulum	protein amino acid phosphorylation, response to stress, apoptosis, sodium ion transport

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	256	ENIEHNSTTSTFCGTPEYLAP	PDK-1	10191262	LTP	1.00		-	S_TKc	0.29	2R5T	76.03%
S	422	KEAAEAFLGFSYAPPTDSFL	PDK-1	10191262	LTP	1.00		-	S_TK_X	0.19	-	-

Substrate:

SGK2 (potassium channel regulator activity, protein kinase CK2 activity)

Seq-ID:

Q9HBY8 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein serine/threonine kinase activity, potassium channel regulator activity, sodium channel regulator activity, ATP binding		protein amino acid phosphorylation, response to oxidative stress, intracellular protein kinase cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	253	EGVEPEDTTSTFCGTPEYLAP	PDK-1	10548550	LTP	1.00		-	S_TKc	0.36	-	medium

Substrate:

Testis-specific kinase 3 (Ser/Thr kinase)

Seq-ID:

Q9D2E1 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, protein serine/threonine kinase activity, ATP binding	intracellular	intracellular signaling pathway, protein amino acid phosphorylation, sperm capacitation, multicellular organismal development

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	168	LPKSRRELSQTFCGSTAYAAP	PDK-1	16336268	LTP	1.00		-	S_TKc	0.23	-	low