List of substrates found:

Histone deacetylase 4  Raf1  Integrin beta 2  RIN1  WEE 1 tyrosine kinase  BAD  Pde3a  Cytokeratin 18  HDAC7A  Orphan nuclear receptor NR4A1  Glucocorticoid receptor  cdc25c  CHK1  PCTAIRE1  Tristetraproline  MAP3K5  Kinase suppressor of ras-1  p53  HDAC5 


Substrate: Histone deacetylase 4 (Enzyme: Deacetylase)
Seq-ID: P56524 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-49703   MEF2A_HUMAN
MINT-49706   MEF2C_HUMAN
MINT-3296491   1433Z_HUMAN
MINT-3975818   1433S_HUMAN
MINT-6802058   HIF1A_HUMAN
MINT-7144512   ZN148_HUMAN
MINT-7299965   BUB1B_HUMAN
MINT-7555703   ATF2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
potassium ion binding,
transcription repressor binding,
specific transcriptional repressor activity,
transcription activator binding,
transcription activator activity,
histone deacetylase activity,
histone deacetylase binding,
zinc ion binding		 histone deacetylase complex,
transcriptional repressor complex		 B cell differentiation,
negative regulation of gene-specific transcription from RNA polymerase II promoter,
nervous system development,
positive regulation of cell proliferation,
negative regulation of transcription factor activity,
positive regulation of gene-specific transcription from RNA polymerase II promoter,
negative regulation of myotube differentiation,
transcription,
histone H4 deacetylation,
positive regulation of transcription factor activity,
response to denervation involved in regulation of muscle adaptation,
inflammatory response,
histone H3 deacetylation,
response to interleukin-1,
chromatin remodeling,
cardiac muscle hypertrophy in response to stress,
negative regulation of glycolysis,
positive regulation of protein sumoylation,
peptidyl-lysine deacetylation,
regulation of protein binding
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 246 KDDFPLRKTASEPNLKLRSRL - 10958686
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.64
 - low
S 246 KDDFPLRKTASEPNLKLRSRL - 10869435
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.64
 - low
S 467 RQHRPLGRTQSAPLPQNAQAL CaM-KIV 11470791
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.84
 - low
S 467 RQHRPLGRTQSAPLPQNAQAL - 18669648
HTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.84
 - low
S 632 GGHRPLSRAQSSPASATFPVS CaM-KIV 11470791
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.67
 - low
S 632 GGHRPLSRAQSSPASATFPVS - 18669648
HTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.67
 - low

Substrate: Raf1 (RAF proto-oncogene serine/threonine-protein kinase)
Seq-ID: P04049 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19324   KPYM_HUMAN
MINT-24923   RAP1A_HUMAN
MINT-45800   1433Z_HUMAN
MINT-51053   K1C19_HUMAN
MINT-51055   K1C18_HUMAN
MINT-51056   K2C8_HUMAN
MINT-56513   CNKR1_HUMAN
MINT-3389399   PAK1_HUMAN
MINT-3389607   PEBP1_HUMAN
MINT-3975386   1433S_HUMAN
MINT-6946517   RASH_HUMAN
MINT-7014370   MP2K1_HUMAN
MINT-7014449   AKT1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
metal ion binding,
receptor signaling protein activity,
ATP binding,
protein binding		 plasma membrane,
cytosol,
mitochondrial outer membrane		 protein amino acid phosphorylation,
negative regulation of cell proliferation,
apoptosis,
Ras protein signal transduction,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 259 GSLSQRQRSTSTPNVHMVSTT PKA_group 11971957
LTP
1.00
 MOD_PKB_1
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.73
 - medium
S 259 GSLSQRQRSTSTPNVHMVSTT PKB_group 10576742
LTP
1.00
 MOD_PKB_1
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.73
 - medium
S 259 GSLSQRQRSTSTPNVHMVSTT - 12801936
LTP
1.00
 MOD_PKB_1
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.73
 - medium
S 259 GSLSQRQRSTSTPNVHMVSTT - 18220336
HTP
1.00
 MOD_PKB_1
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.73
 - medium
S 259 GSLSQRQRSTSTPNVHMVSTT - 18669648
HTP
1.00
 MOD_PKB_1
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.73
 - medium
S 621 HSLPKINRSASEPSLHRAAHT PKA_group 11971957
LTP
0.99
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.49
 - medium
S 621 HSLPKINRSASEPSLHRAAHT - 9091312
LTP
0.99
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.49
 - medium

Substrate: Integrin beta 2 (Adhesion molecule)
Seq-ID: P05107 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-16748   CSN3_HUMAN
MINT-45894   SHC1_MOUSE
MINT-45897   EPS8_HUMAN
MINT-45904   RBGP1_HUMAN
MINT-45912   GULP1_HUMAN
MINT-45917   NUMB_MOUSE
MINT-45924   DAB1_MOUSE
MINT-45938   IRS1_RAT
MINT-45944   DOK1_MOUSE
MINT-45953   TLN1_MOUSE
MINT-45956   JIP1_HUMAN
MINT-50069   RANB9_HUMAN
MINT-4652127   RADI_HUMAN
MINT-4652150   CYH1_HUMAN
MINT-7226098   ABL1_HUMAN
MINT-7226365   TLN2_HUMAN
MINT-7226634   VAV_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor activity,
protein kinase binding,
glycoprotein binding		 integrin complex apoptosis,
integrin-mediated signaling pathway,
regulation of cell shape,
inflammatory response,
cell-cell signaling,
neutrophil chemotaxis,
cell-matrix adhesion,
regulation of peptidyl-tyrosine phosphorylation,
leukocyte cell-cell adhesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 758 NNDNPLFKSATTTVMNPKFAE PKC_group 11700305
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 Integrin_b_cyt
0.35
 2JF1 93.15%
T 758 NNDNPLFKSATTTVMNPKFAE PKC_alpha 11700305
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 Integrin_b_cyt
0.35
 2JF1 93.15%
T 758 NNDNPLFKSATTTVMNPKFAE PKC_delta 11700305
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 Integrin_b_cyt
0.35
 2JF1 93.15%
T 758 NNDNPLFKSATTTVMNPKFAE PKC_eta 11700305
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 Integrin_b_cyt
0.35
 2JF1 93.15%
T 758 NNDNPLFKSATTTVMNPKFAE - 12682249
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 Integrin_b_cyt
0.35
 2JF1 93.15%

Substrate: RIN1 (Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation)
Seq-ID: Q13671 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13962   1433B_HUMAN
MINT-17571   1433Z_HUMAN
MINT-59456   ABL1_MOUSE
MINT-59459   ABL2_HUMAN
MINT-59464   RASH_HUMAN
MINT-59466   ABL1_HUMAN
MINT-74713   ERBB2_HUMAN
MINT-74714   ERBB3_HUMAN
MINT-7972262   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
GTPase activator activity,
protein binding		 plasma membrane,
cytoplasm,
cytoskeleton		 signal transduction,
endocytosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 351 GRRRPLLRSMSAAFCSLLAPE PKD1 11784866
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.38
 - low
S 351 GRRRPLLRSMSAAFCSLLAPE - 18669648
HTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.38
 - low

Substrate: WEE 1 tyrosine kinase (Dual specificity kinase)
Seq-ID: P30291 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-50988   1433B_HUMAN
MINT-3295375   1433Z_HUMAN
MINT-3975741   1433S_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
magnesium ion binding,
protein serine/threonine kinase activity,
non-membrane spanning protein tyrosine kinase activity,
ATP binding,
protein binding		 nucleoplasm protein amino acid phosphorylation,
cell division,
mitosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 642 LIGKKMNRSVSLTIY       - 15150265
LTP
0.98
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.28
 - medium
S 642 LIGKKMNRSVSLTIY       - 15964826
LTP
0.98
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.28
 - medium

Substrate: BAD (Bcl2-antagonist of cell death (BAD) (Bcl-2 binding component 6) (Bcl- XL/Bcl-2 associated death promoter) (Bcl-2-like 8 protein))
Seq-ID: Q61337 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cytosol,
mitochondrial outer membrane		 induction of apoptosis by extracellular signals,
glucose homeostasis,
cytokine-mediated signaling pathway,
apoptosis,
positive regulation of B cell differentiation,
positive regulation of T cell differentiation,
glucose catabolic process,
cell proliferation,
regulation of caspase activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 112 GAMETRSRHSSYPAGTEEDEG PKB_group 9381178
LTP
1.00
 MOD_PKB_1
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 Bcl-2_BAD
0.88
 - medium
S 112 GAMETRSRHSSYPAGTEEDEG PKB_group 10949026
LTP
1.00
 MOD_PKB_1
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 Bcl-2_BAD
0.88
 - medium
S 112 GAMETRSRHSSYPAGTEEDEG - 15849194
LTP
1.00
 MOD_PKB_1
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 Bcl-2_BAD
0.88
 - medium
S 112 GAMETRSRHSSYPAGTEEDEG RSK_group 10880354
LTP
1.00
 MOD_PKB_1
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 Bcl-2_BAD
0.88
 - medium
S 112 GAMETRSRHSSYPAGTEEDEG - 17242355
HTP
1.00
 MOD_PKB_1
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 Bcl-2_BAD
0.88
 - medium
S 112 GAMETRSRHSSYPAGTEEDEG RSK_group 16103085
LTP
1.00
 MOD_PKB_1
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 Bcl-2_BAD
0.88
 - medium
S 112 GAMETRSRHSSYPAGTEEDEG PKB_group 11983683
LTP
1.00
 MOD_PKB_1
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 Bcl-2_BAD
0.88
 - medium
S 136 ELSPFRGRSRSAPPNLWAAQR PKB_group 9381178
LTP
1.00
 MOD_PKB_1
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 Bcl-2_BAD
0.66
 - medium
S 136 ELSPFRGRSRSAPPNLWAAQR PKB_group 10949026
LTP
1.00
 MOD_PKB_1
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 Bcl-2_BAD
0.66
 - medium
S 155 QRYGRELRRMSDEFEGSFKGL RSK_group 10837486
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 Bcl-2_BAD
0.60
 - medium
S 155 QRYGRELRRMSDEFEGSFKGL - 10837473
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 Bcl-2_BAD
0.60
 - medium
S 155 QRYGRELRRMSDEFEGSFKGL - 15123689
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 Bcl-2_BAD
0.60
 - medium
S 155 QRYGRELRRMSDEFEGSFKGL RSK_group 10880354
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 Bcl-2_BAD
0.60
 - medium

Substrate: Pde3a (Enzyme Pphosphodiesterase)
Seq-ID: Q14432 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-3295899   1433Z_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
metal ion binding,
cGMP-inhibited cyclic-nucleotide phosphodiesterase activity		 integral to membrane lipid metabolic process,
signal transduction
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 428 KLAIPKRLRRSLPPGLLRRVS - 16964243
HTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.49
 - medium
S 428 KLAIPKRLRRSLPPGLLRRVS - 18669648
HTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.49
 - medium

Substrate: Cytokeratin 18 (Structural protein)
Seq-ID: P05783 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-51052   1433Z_HUMAN
MINT-51055   RAF1_HUMAN
MINT-61557   GRB2_HUMAN
MINT-67331   EXOC8_HUMAN
MINT-68023   HGS_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
structural molecule activity,
protein binding		 centriolar satellite,
keratin filament,
perinuclear region of cytoplasm		 negative regulation of apoptosis,
anatomical structure morphogenesis,
cell cycle,
interspecies interaction between organisms,
Golgi to plasma membrane CFTR protein transport
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 34 YGARPVSSAASVYAGAGGSGS - 9524113
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.45
 - low
S 34 YGARPVSSAASVYAGAGGSGS - 16083285
HTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.45
 - low

Substrate: HDAC7A (Enzyme: Deacetylase)
Seq-ID: Q8WUI4 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-3296507   1433Z_HUMAN
MINT-3975829   1433S_HUMAN
MINT-6177417   KPCD2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein kinase C binding,
transcription repressor binding,
histone deacetylase activity		 histone deacetylase complex,
cytoplasm		 negative regulation of interleukin-2 production,
chromatin modification,
transcription,
positive regulation of cell migration involved in sprouting angiogenesis,
negative regulation of osteoblast differentiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 155 PEHFPLRKTVSEPNLKLRYKP PKD1 15623513
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.63
 - medium
S 155 PEHFPLRKTVSEPNLKLRYKP MARK_group 16980613
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.63
 - medium
S 155 PEHFPLRKTVSEPNLKLRYKP PKD1 18617643
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.63
 - medium
S 155 PEHFPLRKTVSEPNLKLRYKP PKD1 18509061
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.63
 - medium

Substrate: Orphan nuclear receptor NR4A1 (Orphan nuclear receptor HMR (Early response protein NAK1) (TR3 orphan receptor))
Seq-ID: P12813 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
sequence-specific DNA binding,
protein heterodimerization activity,
protein homodimerization activity,
transcription activator activity,
zinc ion binding,
sequence-specific DNA binding transcription factor activity,
steroid hormone receptor activity		 nucleus transcription,
negative regulation of caspase activity,
induction of apoptosis,
positive regulation of transcription from RNA polymerase II promoter
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 354 SLKGRRGRLPSKPKQPPDASP - 9322922
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.77
 1CIT 100.82%

Substrate: Glucocorticoid receptor (Transcription factor)
Seq-ID: P04150 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14116   1433S_HUMAN
MINT-3373920   LCK_HUMAN
MINT-3373954   CD4_HUMAN
MINT-3374054   CD3D_HUMAN
MINT-6771456   KS6A5_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
sequence-specific DNA binding,
glucocorticoid receptor activity,
steroid binding,
zinc ion binding,
sequence-specific DNA binding transcription factor activity,
protein binding		 mitochondrial matrix,
nucleus		 transcription from RNA polymerase II promoter,
chromatin modification,
response to protein stimulus,
superior temporal gyrus development,
regulation of transcription, DNA-dependent
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 134 ESIANLNRSTSVPENPKSSAS - 18669648
HTP
0.15
 SFN 14-3-3 GCR
0.72
 - low

Substrate: cdc25c (M-phase inducer phosphatase 3)
Seq-ID: P30307 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16690   PLK1_HUMAN
MINT-3294433   1433Z_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein tyrosine phosphatase activity,
WW domain binding		 cytosol,
nucleoplasm		 regulation of cyclin-dependent protein kinase activity,
cell division,
traversing start control point of mitotic cell cycle,
protein amino acid dephosphorylation,
regulation of mitosis,
mitosis,
interspecies interaction between organisms,
DNA replication,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 216 VSRSGLYRSPSMPENLNRPRL CHK2 10744722
LTP
0.98
 CDC25C 14-3-3;
NPHP1 14-3-3;
SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 M-inducer_phosp
0.66
 - low
S 216 VSRSGLYRSPSMPENLNRPRL - 15629715
LTP
0.98
 CDC25C 14-3-3;
NPHP1 14-3-3;
SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 M-inducer_phosp
0.66
 - low
S 216 VSRSGLYRSPSMPENLNRPRL CHK2 9836640
LTP
0.98
 CDC25C 14-3-3;
NPHP1 14-3-3;
SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 M-inducer_phosp
0.66
 - low
S 216 VSRSGLYRSPSMPENLNRPRL BRSK1 9543386
LTP
0.98
 CDC25C 14-3-3;
NPHP1 14-3-3;
SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 M-inducer_phosp
0.66
 - low

Substrate: CHK1 (Serine/threonine-protein kinase Chk1)
Seq-ID: O14757 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-51394   CSK2B_HUMAN
MINT-1958329   P53_HUMAN
MINT-4793746   RB_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
ATP binding,
protein binding		 condensed nuclear chromosome,
microtubule organizing center,
nucleoplasm		 protein amino acid phosphorylation,
regulation of cyclin-dependent protein kinase activity,
senescence,
DNA repair,
reciprocal meiotic recombination,
negative regulation of cell proliferation,
DNA damage checkpoint,
gamete generation,
DNA replication
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 345 IDKLVQGISFSQPTCPDHMLL ATR 11390642
LTP
1.00
 MOD_PIKK_1
 SFN 14-3-3;
YWHAZ 14-3-3		 -
0.30
 --
S 345 IDKLVQGISFSQPTCPDHMLL ATR 10859164
LTP
1.00
 MOD_PIKK_1
 SFN 14-3-3;
YWHAZ 14-3-3		 -
0.30
 --
S 345 IDKLVQGISFSQPTCPDHMLL ATM 15533933
LTP
1.00
 MOD_PIKK_1
 SFN 14-3-3;
YWHAZ 14-3-3		 -
0.30
 --
S 345 IDKLVQGISFSQPTCPDHMLL ATR 15533933
LTP
1.00
 MOD_PIKK_1
 SFN 14-3-3;
YWHAZ 14-3-3		 -
0.30
 --
S 345 IDKLVQGISFSQPTCPDHMLL - 15674326
LTP
1.00
 MOD_PIKK_1
 SFN 14-3-3;
YWHAZ 14-3-3		 -
0.30
 --

Substrate: PCTAIRE1 (Serine/threonine-protein kinase PCTAIRE-1)
Seq-ID: Q00536 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cyclin-dependent protein kinase activity,
ATP binding,
protein binding		 protein amino acid phosphorylation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 119 ISTEDINKRLSLPADIRLPEG PKA_group 12154078
LTP
0.96
 MOD_PKA_1
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.47
 - medium
S 119 ISTEDINKRLSLPADIRLPEG - 17192257
HTP
0.96
 MOD_PKA_1
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.47
 - medium
S 153 KPLSRRLRRVSLSEIGFGKLE PKA_group 12154078
LTP
0.96
 MOD_PKA_1
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.23
 - medium
S 153 KPLSRRLRRVSLSEIGFGKLE - 17192257
HTP
0.96
 MOD_PKA_1
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.23
 - medium
S 153 KPLSRRLRRVSLSEIGFGKLE - 18669648
HTP
0.96
 MOD_PKA_1
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.23
 - medium

Substrate: Tristetraproline (tristetraproline (TTP) (TIS11A) (TIS11) (ZFP-36) (from PhosphoBase))
Seq-ID: P22893 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
DNA binding,
AU-rich element binding,
mRNA binding,
zinc ion binding		 cytosol,
nucleus		 negative regulation of myeloid cell differentiation,
negative regulation of inflammatory response,
nuclear-transcribed mRNA poly(A) tail shortening,
regulation of mRNA stability,
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening,
RNA destabilization,
intracellular protein kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 178 GQPHVLRQSISFSGLPSGRRS MAPKAPK2 14688255
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAG 14-3-3;
YWHAZ 14-3-3		 -
0.65
 - low

Substrate: MAP3K5 (Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.1. -) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1)
Seq-ID: Q99683 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16168   M3K3_HUMAN
MINT-18083   M3K2_HUMAN
MINT-18459   DAB2P_HUMAN
MINT-3391607   MP2K7_HUMAN
MINT-7263196   ARRB2_HUMAN
MINT-7263254   ARRB1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
magnesium ion binding,
protein homodimerization activity,
ATP binding,
caspase activator activity,
MAP kinase kinase kinase activity		 induction of apoptosis by extracellular signals,
apoptosis,
activation of JUN kinase activity,
interspecies interaction between organisms
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 966 AGSNEYLRSISLPVPVLVEDT MAP3K5 10411906
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.33
 --

Substrate: Kinase suppressor of ras-1 (ATP binding)
Seq-ID: Q61097 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13707   1433B_HUMAN
MINT-13837   CDC37_HUMAN
MINT-14037   HS90B_HUMAN
MINT-16002   MP2K1_HUMAN
MINT-17370   HSP71_HUMAN
MINT-17529   MP2K2_HUMAN
MINT-17608   MK03_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein serine/threonine kinase activity,
metal ion binding,
ATP binding,
protein binding		 cytoplasm,
membrane		 protein amino acid phosphorylation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 297 PSFPTLTRSKSHESQLGNRID - 9858547
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.59
 - medium
S 392 LPLARLRRTESVPSDINNPVD - 9858547
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.61
 - medium
S 392 LPLARLRRTESVPSDINNPVD - 12105213
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.61
 - medium

Substrate: p53 (Cellular tumor antigen p53)
Seq-ID: P04637 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-13742   CHK2_HUMAN
MINT-15878   UBP7_HUMAN
MINT-16161   BRCA1_HUMAN
MINT-16977   PARP1_HUMAN
MINT-19990   PIN1_HUMAN
MINT-24859   ASPP2_HUMAN
MINT-45889   CEBPZ_HUMAN
MINT-49767   ATM_HUMAN
MINT-50577   SAE1_HUMAN
MINT-56524   SP1_HUMAN
MINT-58470   MED1_HUMAN
MINT-58672   HNRL1_HUMAN
MINT-60094   HIPK2_HUMAN
MINT-61312   MK08_HUMAN
MINT-61317   WWOX_HUMAN
MINT-62206   PP1A_HUMAN
MINT-63290   ARI2_HUMAN
MINT-63365   KITH_HUMAN
MINT-63497   ZNF24_HUMAN
MINT-63537   IF2B_HUMAN
MINT-63547   RAB4A_HUMAN
MINT-63559   SAT1_HUMAN
MINT-64119   STX5_HUMAN
MINT-64188   MD2BP_HUMAN
MINT-64748   K0087_HUMAN
MINT-65132   HSPB1_HUMAN
MINT-65272   MPH6_HUMAN
MINT-68565   BMX_HUMAN
MINT-74886   NPM_HUMAN
MINT-74925   1433Z_HUMAN
MINT-1795431   NMT1_HUMAN
MINT-1891378   CDN1A_HUMAN
MINT-1958329   CHK1_HUMAN
MINT-2634790   RGRF1_HUMAN
MINT-2858243   DVL2_HUMAN
MINT-2866927   SCAM1_HUMAN
MINT-3390028   KC1D_RAT
MINT-3979604   P53_MOUSE
MINT-4049689   NR4A1_HUMAN
MINT-4052116   SYVN1_HUMAN
MINT-4052873   GRP78_HUMAN
MINT-4302642   HS71L_HUMAN
MINT-4303978   XPO1_HUMAN
MINT-4329805   TOPRS_HUMAN
MINT-4793180   EGR1_HUMAN
MINT-4793253   GSK3B_HUMAN
MINT-4793489   PML_HUMAN
MINT-5114724   ZN363_HUMAN
MINT-5207405   HDAC8_HUMAN
MINT-6540866   PSME3_HUMAN
MINT-6540889   MDM2_HUMAN
MINT-6628692   LT_SV40
MINT-6665320   CBP_HUMAN
MINT-6701342   MAP1B_HUMAN
MINT-7013631   PA1_HUMAN
MINT-7013916   RYBP_HUMAN
MINT-7103733   ANDR_HUMAN
MINT-7144912   TOE1_HUMAN
MINT-7222784   FRAP_HUMAN
MINT-7263630   EP300_HUMAN
MINT-7266250   PLK1_HUMAN
MINT-7294020   FAK1_HUMAN
MINT-7295816   IKKB_HUMAN
MINT-7557644   GRP75_HUMAN
MINT-7711943   1433S_HUMAN
MINT-7717378   PHB_HUMAN
MINT-7718917   SNAI1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transcription activator activity,
protease binding,
DNA strand annealing activity,
chromatin binding,
copper ion binding,
ATP binding,
transcription factor binding,
chaperone binding,
zinc ion binding,
histone acetyltransferase binding,
promoter binding,
sequence-specific DNA binding transcription factor activity,
protein N-terminus binding,
protein heterodimerization activity,
protein phosphatase 2A binding,
protein kinase binding,
ubiquitin protein ligase binding		 nucleolus,
nuclear matrix,
insoluble fraction,
protein complex,
endoplasmic reticulum,
PML body,
mitochondrion		 positive regulation of gene-specific transcription from RNA polymerase II promoter,
senescence,
mitotic cell cycle G1/S DNA damage checkpoint,
cell cycle arrest,
regulation of mitochondrial membrane permeability,
response to gamma radiation,
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator,
response to tumor cell,
ER overload response,
DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis,
interspecies interaction between organisms,
Ras protein signal transduction,
nucleotide-excision repair,
protein tetramerization,
cellular response to glucose starvation,
negative regulation of helicase activity,
negative regulation of cell growth,
base-excision repair,
activation of caspase activity by cytochrome c,
cell aging
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 376 SSHLKSKKGQSTSRHKKLMFK CDK7 9315650
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.81
 --
S 378 HLKSKKGQSTSRHKKLMFKTE CDK7 9315650
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAE 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.82
 --

Substrate: HDAC5 (histone deacetylase activity, specific transcriptional repressor activity)
Seq-ID: Q9UQL6 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-65796   EF1G_HUMAN
MINT-3318337   1433Z_HUMAN
MINT-6802102   HIF1A_HUMAN
MINT-7299978   BUB1B_HUMAN
MINT-7710106   PKN2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein kinase C binding,
transcription repressor binding,
specific transcriptional repressor activity,
histone deacetylase activity,
transcription factor binding		 histone deacetylase complex,
cytoplasm		 B cell differentiation,
negative regulation of gene-specific transcription from RNA polymerase II promoter,
positive regulation of gene-specific transcription from RNA polymerase II promoter,
negative regulation of myotube differentiation,
transcription,
histone deacetylation,
positive regulation of transcription factor activity,
chromatin silencing,
inflammatory response,
negative regulation of cell migration involved in sprouting angiogenesis,
chromatin remodeling,
cellular response to insulin stimulus,
regulation of protein binding
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 259 RDDFPLRKTASEPNLKVRSRL CaM-KIV 11081517
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.69
 - medium
S 498 PRHRPLSRTQSSPLPQSPQAL CaM-KIV 11081517
LTP
1.00
 SFN 14-3-3;
YWHAB 14-3-3;
YWHAG 14-3-3;
YWHAH 14-3-3;
YWHAQ 14-3-3;
YWHAZ 14-3-3		 -
0.88
 - medium

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