List of substrates found:

FCER1G  Estrogen receptor alpha  CD3 epsilon  Bcr  Common beta c subunit  PKC delta  FGFR-3  Gab2  FCGR2B  c-kit  MS4A2  EGFR  CD79A  IL-4R alpha  RET  CD136  PDGF-R beta  CD3 zeta  TIE2 (TEK)  Tpo-R  Amyloid beta A4 protein  TRKA  Insulin R  ErbB2 


Substrate: FCER1G (FceRI gamma)
Seq-ID: P30273 [Homo sapiens]
Interaction Network(s):
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 65 ITSYEKSDGVYTGLSTRNQET - 18088087
HTP
1.00
FES SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.29
- low
Y 65 ITSYEKSDGVYTGLSTRNQET - 18083107
HTP
1.00
FES SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.29
- low
Y 76 TGLSTRNQETYETLKHEKPPQ - 18088087
HTP
1.00
FES SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.54
- low
Y 76 TGLSTRNQETYETLKHEKPPQ - 18083107
HTP
1.00
FES SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.54
- low

Substrate: Estrogen receptor alpha (Estrogen receptor (ER) (Estradiol receptor) (ER-alpha); nuclear hormone receptor. )
Seq-ID: P03372 [Homo sapiens]
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 52 VYLDSSKPAVYNYPEGAAYEF - 20101225
LTP
0.00
SHC1 SH2 Oest_recep
0.31
--

Substrate: CD3 epsilon (T cell surface glycoprotein)
Seq-ID: P07766 [Homo sapiens]
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 188 ERPPPVPNPDYEPIRKGQRDL - 15592455
HTP
1.00
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.67
- medium
Y 188 ERPPPVPNPDYEPIRKGQRDL - 16094384
HTP
1.00
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.67
- medium
Y 188 ERPPPVPNPDYEPIRKGQRDL - 15659558
HTP
1.00
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.67
- medium
Y 199 EPIRKGQRDLYSGLNQRRI   - 12522270
HTP
1.00
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.40
- medium
Y 199 EPIRKGQRDLYSGLNQRRI   - 15144186
HTP
1.00
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.40
- medium
Y 199 EPIRKGQRDLYSGLNQRRI   - 15592455
HTP
1.00
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.40
- medium
Y 199 EPIRKGQRDLYSGLNQRRI   - 16094384
HTP
1.00
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.40
- medium
Y 199 EPIRKGQRDLYSGLNQRRI   - 15659558
HTP
1.00
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.40
- medium
Y 199 EPIRKGQRDLYSGLNQRRI   - 18083107
HTP
1.00
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.40
- medium

Substrate: Bcr (Breakpoint cluster region protein)
Seq-ID: P11274 [Homo sapiens]
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 276 GSRPPWPPLEYQPYQSIYVGG Fes 8955135
LTP
0.00
ABL1 SH2;
GRB10 SH2;
GRB2 SH2;
SHC1 SH2;
SHC_group SH2
-
0.58
- medium
Y 279 PPWPPLEYQPYQSIYVGGMME Fes 8955135
LTP
1.00
ABL1 SH2;
GRB10 SH2;
GRB2 SH2;
SHC1 SH2;
SHC_group SH2
-
0.58
- medium
Y 283 PLEYQPYQSIYVGGMMEGEGK Fes 8955135
LTP
1.00
ABL1 SH2;
GRB10 SH2;
GRB2 SH2;
SHC1 SH2;
SHC_group SH2
-
0.61
- medium

Substrate: Common beta c subunit (Cytokine recpetor common beta chain)
Seq-ID: P32927 [Homo sapiens]
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 628 QKSPPPGSLEYLCLPAGGQVQ - 9257712
LTP
1.00
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2;
STAT5 SH2
-
0.71
- medium
Y 628 QKSPPPGSLEYLCLPAGGQVQ - 10362354
LTP
1.00
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2;
STAT5 SH2
-
0.71
- medium
Y 766 PGPVKSGFEGYVELPPIEGRS - 9257712
LTP
1.00
PTPN11 SH2;
SHC1 SH2;
SHC_group SH2;
STAT5 SH2
-
0.69
- medium

Substrate: PKC delta (Protein kinase C, delta)
Seq-ID: P28867 [Mus musculus]
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 332 GSDILDNNGTYGKIWEGSTRC - 19144319
HTP
0.21
SHC1 SH2 -
0.20
- low

Substrate: PKC delta (Protein kinase C, delta)
Seq-ID: Q05655 [Homo sapiens]
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 334 GEDMQDNSGTYGKIWEGSSKC - 18083107
HTP
0.16
SHC1 SH2 -
0.34
--

Substrate: FGFR-3 (Receptor tyrosine kinase)
Seq-ID: P22607 [Homo sapiens]
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 724 DKPANCTHDLYMIMRECWHAA FGFR3 11294897
LTP
1.00
GRB2 SH2;
SHC1 SH2
TyrKc
0.23
- medium

Substrate: Gab2 (Adaptor molecule)
Seq-ID: Q9UQC2 [Homo sapiens]
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 614 APKKSTGSVDYLALDFQPSSP ZAP70 11572860
LTP
0.96
PTPN11 SH2;
SHC1 SH2
-
0.69
- low

Substrate: FCGR2B (protein binding)
Seq-ID: P31994 [Homo sapiens]
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 292 DKVGAENTITYSLLMHPDALE Lyn 8756631
LTP
1.00
INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2
-
0.42
- low
Y 292 DKVGAENTITYSLLMHPDALE BLK 8756631
LTP
1.00
INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2
-
0.42
- low

Substrate: c-kit (Receptor tyrosine kinase)
Seq-ID: P10721 [Homo sapiens]
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 568 KVVEEINGNNYVYIDPTQLPY Kit 9799234
LTP
1.00
Fyn SH2;
MATK SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2
-
0.13
--
Y 570 VEEINGNNYVYIDPTQLPYDH Kit 9799234
LTP
1.00
Fyn SH2;
MATK SH2;
PTPN6 SH2;
SHC1 SH2
-
0.13
--
Y 721 ESSCSDSTNEYMDMKPGVSYV - N.N.
LTP
1.00
MATK SH2;
PIK3R1 SH2;
PIK3R2 SH2;
SHC1 SH2
TyrKc
0.36
--
Y 721 ESSCSDSTNEYMDMKPGVSYV - 9038210
LTP
1.00
MATK SH2;
PIK3R1 SH2;
PIK3R2 SH2;
SHC1 SH2
TyrKc
0.36
--

Substrate: MS4A2 (calcium channel activity)
Seq-ID: Q01362 [Homo sapiens]
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 219 KGNKVPEDRVYEELNIYSATY - 15339926
LTP
0.12
FES SH2;
Lyn SH2;
SHC1 SH2;
SYK SH2
-
0.21
- medium

Substrate: EGFR (Receptor for EGF and other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor,)
Seq-ID: P00533 [Homo sapiens]
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1197 FKGSTAENAEYLRVAPQSSEF EGFR 8845374
LTP
1.00
ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2
-
0.54
--
Y 1197 FKGSTAENAEYLRVAPQSSEF - 15302935
HTP
1.00
ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2
-
0.54
--
Y 1197 FKGSTAENAEYLRVAPQSSEF - 17081983
HTP
1.00
ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2
-
0.54
--
Y 1197 FKGSTAENAEYLRVAPQSSEF - 18083107
HTP
1.00
ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2
-
0.54
--

Substrate: CD79A (B cell antigen receptor)
Seq-ID: P11912 [Homo sapiens]
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 188 AGDEYEDENLYEGLNLDDCSM Lyn 9531288
LTP
1.00
LIG_TYR_ITAM
BLK SH2;
SHC1 SH2;
SYK SH2
ITAM
0.35
- low
Y 199 EGLNLDDCSMYEDISRGLQGT Fyn 9531288
LTP
1.00
LIG_TYR_ITAM
BLK SH2;
SHC1 SH2
ITAM
0.26
- low

Substrate: IL-4R alpha (Cytokin receptor)
Seq-ID: P24394 [Homo sapiens]
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 497 TPLVIAGNPAYRSFSNSLSQS - 9545332
LTP
1.00
FRS2 PTB;
IRS1 PTB;
SHC1 SH2
-
0.47
- medium
Y 497 TPLVIAGNPAYRSFSNSLSQS - 9697832
LTP
1.00
FRS2 PTB;
IRS1 PTB;
SHC1 SH2
-
0.47
- medium
Y 713 LVDSLGSGIVYSALTCHLCGH - 9670964
LTP
1.00
INPP5D SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2
-
0.17
- medium

Substrate: RET (Probable receptor with tyrosine-protein kinase activity; important for development.)
Seq-ID: P07949 [Homo sapiens]
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1015 LEKMMVKRRDYLDLAASTPSD - 11470823
LTP
1.00
PLCG1 SH2;
SHC1 SH2;
Src SH2
-
0.33
--
Y 1015 LEKMMVKRRDYLDLAASTPSD RET 14981541
LTP
1.00
PLCG1 SH2;
SHC1 SH2;
Src SH2
-
0.33
--
Y 1062 LPSTWIENKLYGMSDPNWPGE - 11470823
LTP
0.19
FRS2 PTB;
IRS1 PTB;
PIK3R1 SH2;
SHC1 PTB;
SHC1 SH2;
SHC3 PTB;
SHC3 SH2
-
0.43
--
Y 1062 LPSTWIENKLYGMSDPNWPGE RET 14711813
LTP
0.19
FRS2 PTB;
IRS1 PTB;
PIK3R1 SH2;
SHC1 PTB;
SHC1 SH2;
SHC3 PTB;
SHC3 SH2
-
0.43
--
Y 1062 LPSTWIENKLYGMSDPNWPGE RET 14981541
LTP
0.19
FRS2 PTB;
IRS1 PTB;
PIK3R1 SH2;
SHC1 PTB;
SHC1 SH2;
SHC3 PTB;
SHC3 SH2
-
0.43
--

Substrate: CD136 (Receptor tyrosine kinase)
Seq-ID: Q04912 [Homo sapiens]
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1353 QIVSALLGDHYVQLPATYMNL RON 10871856
LTP
1.00
GRB2 SH2;
PIK3R1 SH2;
PLCG1 SH2;
SHC1 SH2
-
0.21
- low
Y 1360 GDHYVQLPATYMNLGPSTSHE RON 10871856
LTP
1.00
GRB2 SH2;
PIK3R1 SH2;
PLCG1 SH2;
SHC1 SH2
-
0.40
- low

Substrate: PDGF-R beta (Beta platelet-derived growth factor receptor)
Seq-ID: P09619 [Homo sapiens]
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 579 IESVSSDGHEYIYVDPMQLPY PDGFR_beta 8195171
LTP
1.00
Fyn SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2;
SLA SH2;
Src SH2;
STAT5 SH2;
YES1 SH2
-
0.15
- medium
Y 740 VSLTGESDGGYMDMSKDESVD PDGFR_beta 8195171
LTP
1.00
Fyn SH2;
NCK SH2;
PIK3R1 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2
TyrKc
0.45
- medium
Y 751 MDMSKDESVDYVPMLDMKGDV PDGFR_beta 8195171
LTP
1.00
Fyn SH2;
NCK SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2;
Src SH2
TyrKc
0.29
- medium
Y 751 MDMSKDESVDYVPMLDMKGDV PDGFR_group 8195171
LTP
1.00
Fyn SH2;
NCK SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2;
Src SH2
TyrKc
0.29
- medium
Y 771 VKYADIESSNYMAPYDNYVPS PDGFR_beta 8195171
LTP
1.00
CRK SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2
TyrKc
0.25
- medium

Substrate: CD3 zeta (T-cell surface glycoprotein CD3 zeta chain precursor (from PhosphoBase))
Seq-ID: P20963 [Homo sapiens]
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 72 PAYQQGQNQLYNELNLGRREE - 15144186
HTP
1.00
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.44
- medium
Y 72 PAYQQGQNQLYNELNLGRREE - 15592455
HTP
1.00
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.44
- medium
Y 72 PAYQQGQNQLYNELNLGRREE - 16094384
HTP
1.00
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.44
- medium
Y 72 PAYQQGQNQLYNELNLGRREE - 15659558
HTP
1.00
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.44
- medium
Y 111 QRRKNPQEGLYNELQKDKMAE Fyn 8578591
LTP
1.00
LIG_TYR_ITAM
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.63
- medium
Y 111 QRRKNPQEGLYNELQKDKMAE - 12522270
HTP
1.00
LIG_TYR_ITAM
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.63
- medium
Y 111 QRRKNPQEGLYNELQKDKMAE - 15144186
HTP
1.00
LIG_TYR_ITAM
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.63
- medium
Y 111 QRRKNPQEGLYNELQKDKMAE - 15592455
HTP
1.00
LIG_TYR_ITAM
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.63
- medium
Y 111 QRRKNPQEGLYNELQKDKMAE - 16094384
HTP
1.00
LIG_TYR_ITAM
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.63
- medium
Y 111 QRRKNPQEGLYNELQKDKMAE - 15659558
HTP
1.00
LIG_TYR_ITAM
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.63
- medium
Y 111 QRRKNPQEGLYNELQKDKMAE - 18083107
HTP
1.00
LIG_TYR_ITAM
Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.63
- medium
Y 142 RRRGKGHDGLYQGLSTATKDT - 12522270
HTP
1.00
Fyn SH2;
Lck SH2;
PLCG1 SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.65
- medium
Y 142 RRRGKGHDGLYQGLSTATKDT - 15592455
HTP
1.00
Fyn SH2;
Lck SH2;
PLCG1 SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.65
- medium
Y 142 RRRGKGHDGLYQGLSTATKDT - 16094384
HTP
1.00
Fyn SH2;
Lck SH2;
PLCG1 SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.65
- medium
Y 142 RRRGKGHDGLYQGLSTATKDT - 15659558
HTP
1.00
Fyn SH2;
Lck SH2;
PLCG1 SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2
ITAM
0.65
- medium

Substrate: TIE2 (TEK) (PTK receptor for angiopoietin 1)
Seq-ID: Q02763 [Homo sapiens]
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1102 LNRMLEERKTYVNTTLYEKFT - 10521483
LTP
1.00
GRB2 SH2;
GRB7 SH2;
PIK3R1 SH2;
PIK3R2 SH2;
SHC1 SH2
-
0.15
1FVR 3.49%
Y 1102 LNRMLEERKTYVNTTLYEKFT - 9632797
LTP
1.00
GRB2 SH2;
GRB7 SH2;
PIK3R1 SH2;
PIK3R2 SH2;
SHC1 SH2
-
0.15
1FVR 3.49%
Y 1102 LNRMLEERKTYVNTTLYEKFT TIE2 12082108
LTP
1.00
GRB2 SH2;
GRB7 SH2;
PIK3R1 SH2;
PIK3R2 SH2;
SHC1 SH2
-
0.15
1FVR 3.49%

Substrate: Tpo-R (Thrombopoietin R mlp belongs to the hematopoietic R superfamily)
Seq-ID: P40238 [Homo sapiens]
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cytokine receptor activity integral to plasma membrane cell proliferation
Conservation:

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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 626 CCTTHIANHSYLPLSYWQQP  - 9122198
LTP
1.00
SHC1 SH2;
SHC PTB;
STAT5 SH2
-
0.18
- medium

Substrate: Amyloid beta A4 protein (Cell surface receptor)
Seq-ID: P05067 [Homo sapiens]
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 757 RHLSKMQQNGYENPTYKFFEQ - 11279131
LTP
1.00
ABL1 SH2;
GRB2 SH2;
SHC1 SH2
APP_amyloid
0.38
--
Y 757 RHLSKMQQNGYENPTYKFFEQ - 18083107
HTP
1.00
ABL1 SH2;
GRB2 SH2;
SHC1 SH2
APP_amyloid
0.38
--

Substrate: TRKA (Required for high affinity binding to nerve growth factor , neurotrophin-3 and neurotrophin-4/5r.)
Seq-ID: P04629 [Homo sapiens]
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
GO-Terms:
[show]
Conservation:

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Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 496 LQGHIIENPQYFSDACVHHIK TRKA 11159935
LTP
1.00
FRS2 PTB;
GRB2 SH2;
PLCG1 SH2;
SHC1 PTB;
SHC1 SH2
-
0.16
- medium
Y 496 LQGHIIENPQYFSDACVHHIK TRKA 8155326
LTP
1.00
FRS2 PTB;
GRB2 SH2;
PLCG1 SH2;
SHC1 PTB;
SHC1 SH2
-
0.16
- medium
Y 791 LQALAQAPPVYLDVLG      TRKA 11159935
LTP
1.00
MATK SH2;
PLCG1 SH2;
SHC1 SH2
-
0.11
- medium
Y 791 LQALAQAPPVYLDVLG      TRKA 8155326
LTP
1.00
MATK SH2;
PLCG1 SH2;
SHC1 SH2
-
0.11
- medium

Substrate: Insulin R (Receptor tyrosine kinase)
Seq-ID: P06213 [Homo sapiens]
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
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Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 999 GPLYASSNPEYLSASDVFPCS INSR 8662806
LTP
1.00
CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2
-
0.11
--
Y 999 GPLYASSNPEYLSASDVFPCS INSR 1658004
LTP
1.00
CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2
-
0.11
--
Y 999 GPLYASSNPEYLSASDVFPCS - 8393870
LTP
1.00
CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2
-
0.11
--
Y 999 GPLYASSNPEYLSASDVFPCS INSR 10340378
LTP
1.00
CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2
-
0.11
--
Y 1361 FKRSYEEHIPYTHMNGGKKNG INSR 1321605
LTP
0.95
Csk SH2;
GRB10 SH2;
PIK3R1 SH2;
PTPN11 SH2;
SHC1 SH2
-
0.54
--

Substrate: ErbB2 (Receptor tyrosine kinase)
Seq-ID: P04626 [Homo sapiens]
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:

Click here to enable the multiple sequence alignment viewer Jalview (requires Java browser plugin).
Try the unsigned version of the java plugin if the first link does not work for you...
Alternatively, you can download the alignment, conservation features, and phosphosite features to load into Jalview Desktop.
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1221 PAFSPAFDNLYYWDQDPPERG ErbB2 11500516
LTP
0.19
GRB2 SH2;
SHC1 SH2;
SHC_group SH2
-
0.67
- low


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