List of substrates found:

FCER1G  Estrogen receptor alpha  CD3 epsilon  Bcr  Common beta c subunit  PKC delta  FGFR-3  Gab2  FCGR2B  c-kit  MS4A2  EGFR  CD79A  IL-4R alpha  RET  CD136  PDGF-R beta  CD3 zeta  TIE2 (TEK)  Tpo-R  Amyloid beta A4 protein  TRKA  Insulin R  ErbB2 


Substrate: FCER1G (FceRI gamma)
Seq-ID: P30273 [Homo sapiens]
Download:fasta csv
Interaction Network(s):
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
IgE binding,
transmembrane receptor activity		 integral to plasma membrane cell surface receptor linked signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 65 ITSYEKSDGVYTGLSTRNQET - 18088087
HTP
1.00
 FES SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.29
 - low
Y 65 ITSYEKSDGVYTGLSTRNQET - 18083107
HTP
1.00
 FES SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.29
 - low
Y 76 TGLSTRNQETYETLKHEKPPQ - 18088087
HTP
1.00
 FES SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.54
 - low
Y 76 TGLSTRNQETYETLKHEKPPQ - 18083107
HTP
1.00
 FES SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.54
 - low

Substrate: Estrogen receptor alpha (Estrogen receptor (ER) (Estradiol receptor) (ER-alpha); nuclear hormone receptor. )
Seq-ID: P03372 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-13786   BRCA1_HUMAN
MINT-50646   STA5A_HUMAN
MINT-50709   M3K1_HUMAN
MINT-5222241   NCOA1_HUMAN
MINT-6169667   EGFR_HUMAN
MINT-6614126   SMCA4_HUMAN
MINT-6614301   CHD3_HUMAN
MINT-6614361   MTA1_HUMAN
MINT-6614421   MTA2_HUMAN
MINT-6761899   PTN1_HUMAN
MINT-6761906   PTN6_HUMAN
MINT-7013584   PA1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
beta-catenin binding,
nitric-oxide synthase regulator activity,
estrogen response element binding,
steroid binding,
zinc ion binding,
sequence-specific DNA binding transcription factor activity,
estrogen receptor activity		 chromatin remodeling complex response to estradiol stimulus,
transcription, DNA-dependent,
regulation of transcription, DNA-dependent,
positive regulation of retinoic acid receptor signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 52 VYLDSSKPAVYNYPEGAAYEF - 20101225
LTP
0.00
 SHC1 SH2 Oest_recep
0.31
 --

Substrate: CD3 epsilon (T cell surface glycoprotein)
Seq-ID: P07766 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-7213943   NCK2_HUMAN
MINT-7214058   EPS8_HUMAN
MINT-7214076   ES8L2_HUMAN
MINT-7214253   ES8L1_HUMAN
MINT-7234008   NCK1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
T cell receptor binding,
protein heterodimerization activity,
protein kinase binding,
receptor signaling complex scaffold activity,
transmembrane receptor activity,
receptor signaling protein activity		 external side of plasma membrane,
integral to plasma membrane		 signal complex assembly,
G-protein coupled receptor protein signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 188 ERPPPVPNPDYEPIRKGQRDL - 15592455
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.67
 - medium
Y 188 ERPPPVPNPDYEPIRKGQRDL - 16094384
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.67
 - medium
Y 188 ERPPPVPNPDYEPIRKGQRDL - 15659558
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.67
 - medium
Y 199 EPIRKGQRDLYSGLNQRRI   - 12522270
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.40
 - medium
Y 199 EPIRKGQRDLYSGLNQRRI   - 15144186
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.40
 - medium
Y 199 EPIRKGQRDLYSGLNQRRI   - 15592455
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.40
 - medium
Y 199 EPIRKGQRDLYSGLNQRRI   - 16094384
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.40
 - medium
Y 199 EPIRKGQRDLYSGLNQRRI   - 15659558
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.40
 - medium
Y 199 EPIRKGQRDLYSGLNQRRI   - 18083107
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.40
 - medium

Substrate: Bcr (Breakpoint cluster region protein)
Seq-ID: P11274 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-69534   AT2B1_HUMAN
MINT-69536   CLH1_HUMAN
MINT-69537   CFTR_HUMAN
MINT-69540   ZO2_HUMAN
MINT-69542   RGS12_HUMAN
MINT-4961172   AFAD_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
Rho guanyl-nucleotide exchange factor activity,
protein serine/threonine kinase activity,
ATP binding,
GTPase activator activity		 intracellular protein amino acid phosphorylation,
signal transduction,
regulation of Rho protein signal transduction
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 276 GSRPPWPPLEYQPYQSIYVGG Fes 8955135
LTP
0.00
 ABL1 SH2;
GRB10 SH2;
GRB2 SH2;
SHC1 SH2;
SHC_group SH2		 -
0.58
 - medium
Y 279 PPWPPLEYQPYQSIYVGGMME Fes 8955135
LTP
1.00
 ABL1 SH2;
GRB10 SH2;
GRB2 SH2;
SHC1 SH2;
SHC_group SH2		 -
0.58
 - medium
Y 283 PLEYQPYQSIYVGGMMEGEGK Fes 8955135
LTP
1.00
 ABL1 SH2;
GRB10 SH2;
GRB2 SH2;
SHC1 SH2;
SHC_group SH2		 -
0.61
 - medium

Substrate: Common beta c subunit (Cytokine recpetor common beta chain)
Seq-ID: P32927 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cytokine receptor activity granulocyte macrophage colony-stimulating factor receptor complex respiratory gaseous exchange
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 628 QKSPPPGSLEYLCLPAGGQVQ - 9257712
LTP
1.00
 PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2;
STAT5 SH2		 -
0.71
 - medium
Y 628 QKSPPPGSLEYLCLPAGGQVQ - 10362354
LTP
1.00
 PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2;
STAT5 SH2		 -
0.71
 - medium
Y 766 PGPVKSGFEGYVELPPIEGRS - 9257712
LTP
1.00
 PTPN11 SH2;
SHC1 SH2;
SHC_group SH2;
STAT5 SH2		 -
0.69
 - medium

Substrate: PKC delta (Protein kinase C, delta)
Seq-ID: P28867 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein kinase C activity,
metal ion binding,
insulin receptor substrate binding,
ATP binding		 cytoplasm,
membrane		 protein amino acid phosphorylation,
negative regulation of insulin receptor signaling pathway,
negative regulation of peptidyl-tyrosine phosphorylation,
interleukin-10 production,
B cell proliferation,
immunoglobulin mediated immune response,
interleukin-12 production
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 332 GSDILDNNGTYGKIWEGSTRC - 19144319
HTP
0.21
 SHC1 SH2 -
0.20
 - low

Substrate: PKC delta (Protein kinase C, delta)
Seq-ID: Q05655 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-62336   CDCP1_HUMAN
MINT-62340   SRC_HUMAN
MINT-1955124   ABL1_HUMAN
MINT-3973536   NCF1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
enzyme activator activity,
protein C-terminus binding,
metal ion binding,
insulin receptor substrate binding,
calcium-independent protein kinase C activity,
ATP binding,
enzyme binding		 plasma membrane,
cytosol,
nucleus,
endoplasmic reticulum		 protein stabilization,
protein amino acid phosphorylation,
senescence,
negative regulation of insulin receptor signaling pathway,
negative regulation of peptidyl-tyrosine phosphorylation,
signal transduction,
regulation of receptor activity,
negative regulation of protein binding
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 334 GEDMQDNSGTYGKIWEGSSKC - 18083107
HTP
0.16
 SHC1 SH2 -
0.34
 --

Substrate: FGFR-3 (Receptor tyrosine kinase)
Seq-ID: P22607 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
identical protein binding,
fibroblast growth factor binding,
fibroblast growth factor receptor activity,
ATP binding		 integral to plasma membrane positive regulation of cell proliferation,
protein amino acid phosphorylation,
MAPKKK cascade,
cell growth,
JAK-STAT cascade,
skeletal system development
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 724 DKPANCTHDLYMIMRECWHAA FGFR3 11294897
LTP
1.00
 GRB2 SH2;
SHC1 SH2		 TyrKc
0.23
 - medium

Substrate: Gab2 (Adaptor molecule)
Seq-ID: Q9UQC2 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-14688   SHC1_HUMAN
MINT-56633   MK03_HUMAN
MINT-68496   P85A_HUMAN
MINT-7220613   GRB2_HUMAN
MINT-7300434   1433B_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphatidylinositol-3,4-bisphosphate binding,
phosphatidylinositol-3,4,5-trisphosphate binding,
transmembrane receptor protein tyrosine kinase adaptor protein activity		 plasma membrane,
cytoplasm		 positive regulation of cell proliferation,
phosphoinositide-mediated signaling,
positive regulation of mast cell degranulation,
osteoclast differentiation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 614 APKKSTGSVDYLALDFQPSSP ZAP70 11572860
LTP
0.96
 PTPN11 SH2;
SHC1 SH2		 -
0.69
 - low

Substrate: FCGR2B (protein binding)
Seq-ID: P31994 [Homo sapiens]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-74919   PTN6_HUMAN
MINT-74920   SHIP1_HUMAN
MINT-7245214   SRC_HUMAN
MINT-7247446   FYN_HUMAN
MINT-7251178   NCK1_HUMAN
MINT-7252786   PLCG1_HUMAN
MINT-7254142   CRK_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor activity,
IgG binding		 plasma membrane,
integral to membrane		 immune response,
interspecies interaction between organisms
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 292 DKVGAENTITYSLLMHPDALE Lyn 8756631
LTP
1.00
 INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2		 -
0.42
 - low
Y 292 DKVGAENTITYSLLMHPDALE BLK 8756631
LTP
1.00
 INPP5D SH2;
Lyn SH2;
PIK3R1 SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2		 -
0.42
 - low

Substrate: c-kit (Receptor tyrosine kinase)
Seq-ID: P10721 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor signaling protein tyrosine kinase activity,
ATP binding,
protein binding		 integral to membrane,
extracellular space		 male gonad development,
transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 568 KVVEEINGNNYVYIDPTQLPY Kit 9799234
LTP
1.00
 Fyn SH2;
MATK SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2		 -
0.13
 --
Y 570 VEEINGNNYVYIDPTQLPYDH Kit 9799234
LTP
1.00
 Fyn SH2;
MATK SH2;
PTPN6 SH2;
SHC1 SH2		 -
0.13
 --
Y 721 ESSCSDSTNEYMDMKPGVSYV - N.N.
LTP
1.00
 MATK SH2;
PIK3R1 SH2;
PIK3R2 SH2;
SHC1 SH2		 TyrKc
0.36
 --
Y 721 ESSCSDSTNEYMDMKPGVSYV - 9038210
LTP
1.00
 MATK SH2;
PIK3R1 SH2;
PIK3R2 SH2;
SHC1 SH2		 TyrKc
0.36
 --

Substrate: MS4A2 (calcium channel activity)
Seq-ID: Q01362 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
calcium channel activity integral to plasma membrane humoral immune response,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 219 KGNKVPEDRVYEELNIYSATY - 15339926
LTP
0.12
 FES SH2;
Lyn SH2;
SHC1 SH2;
SYK SH2		 -
0.21
 - medium

Substrate: EGFR (Receptor for EGF and other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor,)
Seq-ID: P00533 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16802   GRB10_HUMAN
MINT-50935   1433Z_HUMAN
MINT-51101   ANXA1_HUMAN
MINT-51490   ARBK1_HUMAN
MINT-60973   CBL_HUMAN
MINT-61486   CRKL_HUMAN
MINT-61487   CSK_HUMAN
MINT-61490   STA5B_HUMAN
MINT-61540   GRB2_HUMAN
MINT-68514   PDC6I_HUMAN
MINT-74427   ABL1_HUMAN
MINT-74438   ABL2_HUMAN
MINT-74460   ANS1A_HUMAN
MINT-74469   APBB1_HUMAN
MINT-74479   DP13A_HUMAN
MINT-74487   BMX_HUMAN
MINT-74497   CRK_HUMAN
MINT-74535   FES_HUMAN
MINT-74551   IRS1_HUMAN
MINT-74555   IRS4_HUMAN
MINT-74562   JAK2_HUMAN
MINT-74566   SH2B3_HUMAN
MINT-74572   JIP1_HUMAN
MINT-74587   NCK1_HUMAN
MINT-74593   NUMB_HUMAN
MINT-74594   NUMBL_HUMAN
MINT-74606   P85A_HUMAN
MINT-74630   P85B_HUMAN
MINT-74659   P55G_HUMAN
MINT-74678   PLCG1_HUMAN
MINT-74685   PLCG2_HUMAN
MINT-74687   PTK6_HUMAN
MINT-74689   PTN11_HUMAN
MINT-74711   RASA1_HUMAN
MINT-74717   SH2B1_HUMAN
MINT-74720   SH22A_HUMAN
MINT-74732   SHC1_HUMAN
MINT-74746   SLAP1_HUMAN
MINT-74763   KSYK_HUMAN
MINT-74790   TLN1_HUMAN
MINT-74807   ZAP70_HUMAN
MINT-1788719   ERBB2_HUMAN
MINT-6169667   ESR1_HUMAN
MINT-6170031   SOS1_MOUSE
MINT-6170198   SH3G2_HUMAN
MINT-6170268   SH3K1_HUMAN
MINT-6793358   PTN1_HUMAN
MINT-7980526   TM1L1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
epidermal growth factor receptor activity,
protein heterodimerization activity,
identical protein binding,
receptor signaling protein tyrosine kinase activity,
double-stranded DNA binding,
ATP binding,
protein phosphatase binding,
actin filament binding,
MAP/ERK kinase kinase activity		 Shc-EGFR complex,
endosome,
basolateral plasma membrane,
integral to membrane,
extracellular space,
nucleus		 activation of phospholipase C activity,
protein insertion into membrane,
response to UV-A,
positive regulation of nitric oxide biosynthetic process,
positive regulation of cell migration,
positive regulation of cyclin-dependent protein kinase activity involved in G1/S,
positive regulation of catenin protein nuclear translocation,
regulation of nitric-oxide synthase activity,
positive regulation of protein kinase B signaling cascade,
ossification,
positive regulation of epithelial cell proliferation,
activation of phospholipase A2 activity by calcium-mediated signaling,
cell-cell adhesion,
regulation of peptidyl-tyrosine phosphorylation,
positive regulation of phosphorylation,
positive regulation of MAP kinase activity,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1197 FKGSTAENAEYLRVAPQSSEF EGFR 8845374
LTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2		 -
0.54
 --
Y 1197 FKGSTAENAEYLRVAPQSSEF - 15302935
HTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2		 -
0.54
 --
Y 1197 FKGSTAENAEYLRVAPQSSEF - 17081983
HTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2		 -
0.54
 --
Y 1197 FKGSTAENAEYLRVAPQSSEF - 18083107
HTP
1.00
 ABL1 SH2;
GRB2 SH2;
PLCG1 SH2;
PTPN6 SH2;
RASA_group SH2;
SHC1 SH2;
SHC3 SH2;
Src SH2		 -
0.54
 --

Substrate: CD79A (B cell antigen receptor)
Seq-ID: P11912 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transmembrane receptor activity B cell receptor complex,
external side of plasma membrane,
integral to membrane,
multivesicular body,
membrane raft		 B cell differentiation,
B cell receptor signaling pathway,
B cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 188 AGDEYEDENLYEGLNLDDCSM Lyn 9531288
LTP
1.00
 LIG_TYR_ITAM
 BLK SH2;
SHC1 SH2;
SYK SH2		 ITAM
0.35
 - low
Y 199 EGLNLDDCSMYEDISRGLQGT Fyn 9531288
LTP
1.00
 LIG_TYR_ITAM
 BLK SH2;
SHC1 SH2		 ITAM
0.26
 - low

Substrate: IL-4R alpha (Cytokin receptor)
Seq-ID: P24394 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
MINT-63292   ARI2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor signaling protein activity,
interleukin-4 receptor activity		 extracellular region,
integral to plasma membrane		 immune response
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 497 TPLVIAGNPAYRSFSNSLSQS - 9545332
LTP
1.00
 FRS2 PTB;
IRS1 PTB;
SHC1 SH2		 -
0.47
 - medium
Y 497 TPLVIAGNPAYRSFSNSLSQS - 9697832
LTP
1.00
 FRS2 PTB;
IRS1 PTB;
SHC1 SH2		 -
0.47
 - medium
Y 713 LVDSLGSGIVYSALTCHLCGH - 9670964
LTP
1.00
 INPP5D SH2;
PTPN11 SH2;
PTPN6 SH2;
SHC1 SH2		 -
0.17
 - medium

Substrate: RET (Probable receptor with tyrosine-protein kinase activity; important for development.)
Seq-ID: P07949 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-60970   CBL_HUMAN
MINT-60975   GRB2_HUMAN
MINT-60981   SHC1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
calcium ion binding,
transmembrane receptor protein tyrosine kinase activity,
ATP binding		 integral to membrane protein amino acid phosphorylation,
posterior midgut development,
homophilic cell adhesion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1015 LEKMMVKRRDYLDLAASTPSD - 11470823
LTP
1.00
 PLCG1 SH2;
SHC1 SH2;
Src SH2		 -
0.33
 --
Y 1015 LEKMMVKRRDYLDLAASTPSD RET 14981541
LTP
1.00
 PLCG1 SH2;
SHC1 SH2;
Src SH2		 -
0.33
 --
Y 1062 LPSTWIENKLYGMSDPNWPGE - 11470823
LTP
0.19
 FRS2 PTB;
IRS1 PTB;
PIK3R1 SH2;
SHC1 PTB;
SHC1 SH2;
SHC3 PTB;
SHC3 SH2		 -
0.43
 --
Y 1062 LPSTWIENKLYGMSDPNWPGE RET 14711813
LTP
0.19
 FRS2 PTB;
IRS1 PTB;
PIK3R1 SH2;
SHC1 PTB;
SHC1 SH2;
SHC3 PTB;
SHC3 SH2		 -
0.43
 --
Y 1062 LPSTWIENKLYGMSDPNWPGE RET 14981541
LTP
0.19
 FRS2 PTB;
IRS1 PTB;
PIK3R1 SH2;
SHC1 PTB;
SHC1 SH2;
SHC3 PTB;
SHC3 SH2		 -
0.43
 --

Substrate: CD136 (Receptor tyrosine kinase)
Seq-ID: Q04912 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
MINT-6539679   CBL_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
macrophage colony-stimulating factor receptor activity,
ATP binding,
protein binding		 integral to plasma membrane positive regulation of cell proliferation,
protein amino acid phosphorylation,
cellular component movement,
single fertilization,
transmembrane receptor protein tyrosine kinase signaling pathway,
multicellular organismal development,
defense response
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1353 QIVSALLGDHYVQLPATYMNL RON 10871856
LTP
1.00
 GRB2 SH2;
PIK3R1 SH2;
PLCG1 SH2;
SHC1 SH2		 -
0.21
 - low
Y 1360 GDHYVQLPATYMNLGPSTSHE RON 10871856
LTP
1.00
 GRB2 SH2;
PIK3R1 SH2;
PLCG1 SH2;
SHC1 SH2		 -
0.40
 - low

Substrate: PDGF-R beta (Beta platelet-derived growth factor receptor)
Seq-ID: P09619 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-2832596   NHRF2_HUMAN
MINT-2832984   PTEN_HUMAN
MINT-2833042   NHRF1_HUMAN
MINT-6762380   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
vascular endothelial growth factor receptor activity,
platelet-derived growth factor binding,
platelet activating factor receptor activity,
platelet-derived growth factor receptor binding,
ATP binding,
platelet-derived growth factor beta-receptor activity		 integral to plasma membrane positive regulation of cell proliferation,
positive regulation of cell migration,
protein amino acid autophosphorylation,
peptidyl-tyrosine phosphorylation,
cell chemotaxis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 579 IESVSSDGHEYIYVDPMQLPY PDGFR_beta 8195171
LTP
1.00
 Fyn SH2;
PIK3R1 SH2;
PLCG1 SH2;
PTPN11 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2;
SLA SH2;
Src SH2;
STAT5 SH2;
YES1 SH2		 -
0.15
 - medium
Y 740 VSLTGESDGGYMDMSKDESVD PDGFR_beta 8195171
LTP
1.00
 Fyn SH2;
NCK SH2;
PIK3R1 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2		 TyrKc
0.45
 - medium
Y 751 MDMSKDESVDYVPMLDMKGDV PDGFR_beta 8195171
LTP
1.00
 Fyn SH2;
NCK SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2;
Src SH2		 TyrKc
0.29
 - medium
Y 751 MDMSKDESVDYVPMLDMKGDV PDGFR_group 8195171
LTP
1.00
 Fyn SH2;
NCK SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2;
Src SH2		 TyrKc
0.29
 - medium
Y 771 VKYADIESSNYMAPYDNYVPS PDGFR_beta 8195171
LTP
1.00
 CRK SH2;
PLCG1 SH2;
RASA_group SH2;
SHC1 SH2;
SHC_group SH2		 TyrKc
0.25
 - medium

Substrate: CD3 zeta (T-cell surface glycoprotein CD3 zeta chain precursor (from PhosphoBase))
Seq-ID: P20963 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-60782   LCK_HUMAN
MINT-7301967   NCK1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein homodimerization activity,
transmembrane receptor activity		 cytoplasm,
integral to membrane		 interspecies interaction between organisms
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 72 PAYQQGQNQLYNELNLGRREE - 15144186
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.44
 - medium
Y 72 PAYQQGQNQLYNELNLGRREE - 15592455
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.44
 - medium
Y 72 PAYQQGQNQLYNELNLGRREE - 16094384
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.44
 - medium
Y 72 PAYQQGQNQLYNELNLGRREE - 15659558
HTP
1.00
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.44
 - medium
Y 111 QRRKNPQEGLYNELQKDKMAE Fyn 8578591
LTP
1.00
 LIG_TYR_ITAM
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.63
 - medium
Y 111 QRRKNPQEGLYNELQKDKMAE - 12522270
HTP
1.00
 LIG_TYR_ITAM
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.63
 - medium
Y 111 QRRKNPQEGLYNELQKDKMAE - 15144186
HTP
1.00
 LIG_TYR_ITAM
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.63
 - medium
Y 111 QRRKNPQEGLYNELQKDKMAE - 15592455
HTP
1.00
 LIG_TYR_ITAM
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.63
 - medium
Y 111 QRRKNPQEGLYNELQKDKMAE - 16094384
HTP
1.00
 LIG_TYR_ITAM
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.63
 - medium
Y 111 QRRKNPQEGLYNELQKDKMAE - 15659558
HTP
1.00
 LIG_TYR_ITAM
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.63
 - medium
Y 111 QRRKNPQEGLYNELQKDKMAE - 18083107
HTP
1.00
 LIG_TYR_ITAM
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.63
 - medium
Y 142 RRRGKGHDGLYQGLSTATKDT - 12522270
HTP
1.00
 Fyn SH2;
Lck SH2;
PLCG1 SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.65
 - medium
Y 142 RRRGKGHDGLYQGLSTATKDT - 15592455
HTP
1.00
 Fyn SH2;
Lck SH2;
PLCG1 SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.65
 - medium
Y 142 RRRGKGHDGLYQGLSTATKDT - 16094384
HTP
1.00
 Fyn SH2;
Lck SH2;
PLCG1 SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.65
 - medium
Y 142 RRRGKGHDGLYQGLSTATKDT - 15659558
HTP
1.00
 Fyn SH2;
Lck SH2;
PLCG1 SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.65
 - medium

Substrate: TIE2 (TEK) (PTK receptor for angiopoietin 1)
Seq-ID: Q02763 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transmembrane receptor protein tyrosine kinase activity,
ATP binding,
protein binding		 basolateral plasma membrane,
integral to plasma membrane,
cell surface,
microvillus,
apical plasma membrane,
membrane raft		 positive regulation of ERK1 and ERK2 cascade,
protein amino acid phosphorylation,
protein oligomerization,
cell-cell signaling,
positive regulation of protein kinase B signaling cascade,
regulation of cell proliferation,
transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1102 LNRMLEERKTYVNTTLYEKFT - 10521483
LTP
1.00
 GRB2 SH2;
GRB7 SH2;
PIK3R1 SH2;
PIK3R2 SH2;
SHC1 SH2		 -
0.15
 1FVR 3.49%
Y 1102 LNRMLEERKTYVNTTLYEKFT - 9632797
LTP
1.00
 GRB2 SH2;
GRB7 SH2;
PIK3R1 SH2;
PIK3R2 SH2;
SHC1 SH2		 -
0.15
 1FVR 3.49%
Y 1102 LNRMLEERKTYVNTTLYEKFT TIE2 12082108
LTP
1.00
 GRB2 SH2;
GRB7 SH2;
PIK3R1 SH2;
PIK3R2 SH2;
SHC1 SH2		 -
0.15
 1FVR 3.49%

Substrate: Tpo-R (Thrombopoietin R mlp belongs to the hematopoietic R superfamily)
Seq-ID: P40238 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
cytokine receptor activity integral to plasma membrane cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 626 CCTTHIANHSYLPLSYWQQP  - 9122198
LTP
1.00
 SHC1 SH2;
SHC PTB;
STAT5 SH2		 -
0.18
 - medium

Substrate: Amyloid beta A4 protein (Cell surface receptor)
Seq-ID: P05067 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-14547   JIP1_HUMAN
MINT-49648   APBB1_RAT
MINT-49659   GRB2_HUMAN
MINT-49660   SHC1_HUMAN
MINT-49984   ABL1_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
serine-type endopeptidase inhibitor activity,
DNA binding,
acetylcholine receptor binding,
identical protein binding,
metal ion binding,
heparin binding		 extracellular region,
dendritic shaft,
integral to plasma membrane,
coated pit,
cell surface,
Golgi apparatus,
platelet alpha granule lumen,
axon,
dendritic spine		 dendrite development,
G2 phase of mitotic cell cycle,
positive regulation of mitotic cell cycle,
regulation of multicellular organism growth,
regulation of epidermal growth factor receptor activity,
ionotropic glutamate receptor signaling pathway,
mRNA polyadenylation,
collateral sprouting in the absence of injury,
adult locomotory behavior,
extracellular matrix organization,
Notch signaling pathway,
regulation of translation,
visual learning,
neuron apoptosis,
axon midline choice point recognition,
cell adhesion,
neuron remodeling,
mating behavior,
endocytosis,
axon cargo transport,
cellular copper ion homeostasis,
protein amino acid phosphorylation,
regulation of synapse structure and activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 757 RHLSKMQQNGYENPTYKFFEQ - 11279131
LTP
1.00
 ABL1 SH2;
GRB2 SH2;
SHC1 SH2		 APP_amyloid
0.38
 --
Y 757 RHLSKMQQNGYENPTYKFFEQ - 18083107
HTP
1.00
 ABL1 SH2;
GRB2 SH2;
SHC1 SH2		 APP_amyloid
0.38
 --

Substrate: TRKA (Required for high affinity binding to nerve growth factor , neurotrophin-3 and neurotrophin-4/5r.)
Seq-ID: P04629 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
MINT-6793941   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transmembrane receptor protein tyrosine kinase activity,
neurotrophin receptor activity,
ATP binding		 endosome,
integral to plasma membrane		 activation of adenylate cyclase activity,
Ras protein signal transduction,
transmembrane receptor protein tyrosine kinase signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 496 LQGHIIENPQYFSDACVHHIK TRKA 11159935
LTP
1.00
 FRS2 PTB;
GRB2 SH2;
PLCG1 SH2;
SHC1 PTB;
SHC1 SH2		 -
0.16
 - medium
Y 496 LQGHIIENPQYFSDACVHHIK TRKA 8155326
LTP
1.00
 FRS2 PTB;
GRB2 SH2;
PLCG1 SH2;
SHC1 PTB;
SHC1 SH2		 -
0.16
 - medium
Y 791 LQALAQAPPVYLDVLG      TRKA 11159935
LTP
1.00
 MATK SH2;
PLCG1 SH2;
SHC1 SH2		 -
0.11
 - medium
Y 791 LQALAQAPPVYLDVLG      TRKA 8155326
LTP
1.00
 MATK SH2;
PLCG1 SH2;
SHC1 SH2		 -
0.11
 - medium

Substrate: Insulin R (Receptor tyrosine kinase)
Seq-ID: P06213 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-16516   GRB10_HUMAN
MINT-16842   MD2L1_HUMAN
MINT-18199   IRS2_HUMAN
MINT-19010   IRS1_HUMAN
MINT-73466   GRB10_MOUSE
MINT-6793537   INSR_RAT
MINT-6794075   IRS1_MOUSE
MINT-6794090   INSR_MOUSE
MINT-6794946   PTN1_HUMAN
MINT-6795115   IRS1_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
insulin-like growth factor receptor binding,
insulin binding,
PTB domain binding,
GTP binding,
metal ion binding,
insulin receptor substrate binding,
ATP binding,
insulin-like growth factor I binding,
insulin receptor activity,
SH2 domain binding,
phosphoinositide 3-kinase binding,
insulin-like growth factor II binding,
receptor signaling protein tyrosine kinase activity		 microsome,
caveola,
insulin receptor complex,
endosome membrane		 positive regulation of glycolysis,
positive regulation of MAPKKK cascade,
positive regulation of developmental growth,
regulation of embryonic development,
heart morphogenesis,
positive regulation of cell migration,
carbohydrate metabolic process,
protein heterotetramerization,
positive regulation of protein kinase B signaling cascade,
protein amino acid autophosphorylation,
activation of MAPK activity,
positive regulation of glycogen biosynthetic process,
positive regulation of mitosis,
peptidyl-tyrosine phosphorylation,
positive regulation of glucose import,
positive regulation of respiratory burst,
activation of protein kinase B activity,
G-protein coupled receptor protein signaling pathway,
positive regulation of DNA replication,
positive regulation of protein amino acid phosphorylation,
positive regulation of cell proliferation,
glucose homeostasis,
positive regulation of nitric oxide biosynthetic process,
transformation of host cell by virus,
regulation of gene-specific transcription
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 999 GPLYASSNPEYLSASDVFPCS INSR 8662806
LTP
1.00
 CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2		 -
0.11
 --
Y 999 GPLYASSNPEYLSASDVFPCS INSR 1658004
LTP
1.00
 CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2		 -
0.11
 --
Y 999 GPLYASSNPEYLSASDVFPCS - 8393870
LTP
1.00
 CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2		 -
0.11
 --
Y 999 GPLYASSNPEYLSASDVFPCS INSR 10340378
LTP
1.00
 CRKL SH2;
GRB10 SH2;
IRS1 PTB;
IRS2 PTB;
RASA_group SH2;
SHC1 PTB;
SHC1 SH2;
STAT5 SH2		 -
0.11
 --
Y 1361 FKRSYEEHIPYTHMNGGKKNG INSR 1321605
LTP
0.95
 Csk SH2;
GRB10 SH2;
PIK3R1 SH2;
PTPN11 SH2;
SHC1 SH2		 -
0.54
 --

Substrate: ErbB2 (Receptor tyrosine kinase)
Seq-ID: P04626 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-61505   P85B_HUMAN
MINT-74429   ABL1_HUMAN
MINT-74444   ABL2_HUMAN
MINT-74462   ANS1A_HUMAN
MINT-74470   APBB1_HUMAN
MINT-74486   BLNK_HUMAN
MINT-74488   BMX_HUMAN
MINT-74498   CRK_HUMAN
MINT-74502   CRKL_HUMAN
MINT-74508   DAB1_HUMAN
MINT-74512   DOK1_HUMAN
MINT-74521   SPT6H_HUMAN
MINT-74533   FER_HUMAN
MINT-74538   FGR_HUMAN
MINT-74540   GRAP2_HUMAN
MINT-74542   GRB2_HUMAN
MINT-74544   GRB7_HUMAN
MINT-74553   IRS1_HUMAN
MINT-74556   IRS4_HUMAN
MINT-74558   ITK_HUMAN
MINT-74561   JAK1_HUMAN
MINT-74567   SH2B3_HUMAN
MINT-74575   JIP1_HUMAN
MINT-74582   MATK_HUMAN
MINT-74590   NCK2_HUMAN
MINT-74610   P85A_HUMAN
MINT-74664   P55G_HUMAN
MINT-74680   PLCG1_HUMAN
MINT-74686   PLCG2_HUMAN
MINT-74691   PTN11_HUMAN
MINT-74712   RASA1_HUMAN
MINT-74713   RIN1_HUMAN
MINT-74722   SH22A_HUMAN
MINT-74723   SH23A_HUMAN
MINT-74724   3BP2_HUMAN
MINT-74737   SHC1_HUMAN
MINT-74747   SLAP1_HUMAN
MINT-74755   STAT1_HUMAN
MINT-74756   STAT3_HUMAN
MINT-74769   KSYK_HUMAN
MINT-74777   TEC_HUMAN
MINT-74781   TENC1_HUMAN
MINT-74786   TENS3_HUMAN
MINT-74793   TLN1_HUMAN
MINT-74794   TXK_HUMAN
MINT-74802   VAV2_HUMAN
MINT-1788719   EGFR_HUMAN
MINT-1901925   LAP2_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
epidermal growth factor receptor activity,
ErbB-3 class receptor binding,
protein heterodimerization activity,
DNA binding,
protein C-terminus binding,
identical protein binding,
receptor signaling protein tyrosine kinase activity,
ATP binding,
protein phosphatase binding		 receptor complex,
integral to membrane,
nucleus,
perinuclear region of cytoplasm		 regulation of angiogenesis,
transcription,
regulation of transcription,
phosphoinositide 3-kinase cascade,
phosphoinositide-mediated signaling,
heart development,
positive regulation of cell adhesion,
protein amino acid autophosphorylation,
positive regulation of epithelial cell proliferation,
wound healing,
positive regulation of MAP kinase activity,
cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 1221 PAFSPAFDNLYYWDQDPPERG ErbB2 11500516
LTP
0.19
 GRB2 SH2;
SHC1 SH2;
SHC_group SH2		 -
0.67
 - low

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