a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

HDAC7A  RIN1  Beta-catenin  MAP3K5  p53  RGS7  Raf1  WEE 1 tyrosine kinase  PTPN3  Tristetraproline  Orphan nuclear receptor NR4A1  Histone deacetylase 4  Kinase suppressor of ras-1  PCTAIRE1  Pde3a  Integrin beta 2  BAD  Cytokeratin 18  B-Raf  cdc25c  HDAC5  Phosphodiesterase 3B 

Substrate:	HDAC7A (Enzyme: Deacetylase)
Seq-ID:	Q8WUI4 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-3296507   1433Z_HUMAN MINT-3975829   1433S_HUMAN MINT-6177417   KPCD2_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process protein kinase C binding, transcription repressor binding, histone deacetylase activity histone deacetylase complex, cytoplasm negative regulation of interleukin-2 production, chromatin modification, transcription, positive regulation of cell migration involved in sprouting angiogenesis, negative regulation of osteoblast differentiation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	155	PEHFPLRKTVSEPNLKLRYKP	PKD1	15623513	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.63	-	medium
S	155	PEHFPLRKTVSEPNLKLRYKP	MARK_group	16980613	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.63	-	medium
S	155	PEHFPLRKTVSEPNLKLRYKP	PKD1	18617643	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.63	-	medium
S	155	PEHFPLRKTVSEPNLKLRYKP	PKD1	18509061	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.63	-	medium

Substrate:	RIN1 (Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation)
Seq-ID:	Q13671 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-13962   1433B_HUMAN MINT-17571   1433Z_HUMAN MINT-59456   ABL1_MOUSE MINT-59459   ABL2_HUMAN MINT-59464   RASH_HUMAN MINT-59466   ABL1_HUMAN MINT-74713   ERBB2_HUMAN MINT-74714   ERBB3_HUMAN MINT-7972262   DLG4_RAT
GO-Terms:	[show] Molecular Function Cellular Component Biological Process GTPase activator activity, protein binding plasma membrane, cytoplasm, cytoskeleton signal transduction, endocytosis
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	351	GRRRPLLRSMSAAFCSLLAPE	PKD1	11784866	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.38	-	low
S	351	GRRRPLLRSMSAAFCSLLAPE	-	18669648	HTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.38	-	low

Substrate:	Beta-catenin (Adhesion molecule)
Seq-ID:	P35222 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-46005   CADH1_HUMAN MINT-46006   CTNA1_HUMAN MINT-49803   ANDR_HUMAN MINT-49805   NCOA2_HUMAN MINT-1779698   TF7L2_HUMAN MINT-1792780   LAP2_HUMAN MINT-1792796   PKP4_HUMAN MINT-2839028   LAP2B_HUMAN MINT-2839079   EMD_HUMAN MINT-4085223   CADH5_HUMAN MINT-4085261   PARD3_HUMAN MINT-4085491   CADH2_HUMAN MINT-4508051   GSK3B_HUMAN MINT-4508065   ITF2_HUMAN MINT-4508192   AXN1_HUMAN MINT-4508216   ABL1_HUMAN MINT-4508229   APC_HUMAN MINT-6823807   HDAC1_HUMAN MINT-7023862   NFKB1_HUMAN MINT-7952417   TNIK_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process R-SMAD binding, cadherin binding, androgen receptor binding, alpha-catenin binding, kinase binding, protein phosphatase binding, transcription coactivator activity, promoter binding, signal transducer activity, estrogen receptor binding, I-SMAD binding, protein C-terminus binding Axin-APC-beta-catenin-GSK3B complex, catenin complex, transcription factor complex, perinuclear region of cytoplasm, cell cortex, protein-DNA complex, beta-catenin-TCF7L2 complex, centrosome, cell-substrate adherens junction, lateral plasma membrane positive regulation of gene-specific transcription from RNA polymerase II promoter, patterning of blood vessels, protein localization at cell surface, positive regulation of heparan sulfate proteoglycan biosynthetic process, negative regulation of cell proliferation, cellular response to indole-3-methanol, response to drug, positive regulation of anti-apoptosis, positive regulation of apoptosis, canonical Wnt receptor signaling pathway, regulation of calcium ion import, androgen receptor signaling pathway, adherens junction assembly, regulation of fibroblast proliferation, epithelial to mesenchymal transition, regulation of smooth muscle cell proliferation, cell-cell adhesion, cellular response to growth factor stimulus, positive regulation of epithelial to mesenchymal transition, regulation of angiogenesis, endothelial tube morphogenesis, negative regulation of apoptosis, transcription, regulation of centriole-centriole cohesion, regulation of centromeric sister chromatid cohesion, response to estradiol stimulus
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	552	RAHQDTQRRTSMGGTQQQFVE	-	18220336	HTP	0.83		YWHAB 14-3-3	ARM	0.57	1QZ7	72.95%
S	552	RAHQDTQRRTSMGGTQQQFVE	-	18669648	HTP	0.83		YWHAB 14-3-3	ARM	0.57	1QZ7	72.95%

Substrate:	MAP3K5 (Mitogen-activated protein kinase kinase kinase 5 (EC 2.7.1. -) (MAPK/ERK kinase kinase 5) (MEK kinase 5) (MEKK 5) (Apoptosis signal- regulating kinase 1) (ASK-1)
Seq-ID:	Q99683 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-16168   M3K3_HUMAN MINT-18083   M3K2_HUMAN MINT-18459   DAB2P_HUMAN MINT-3391607   MP2K7_HUMAN MINT-7263196   ARRB2_HUMAN MINT-7263254   ARRB1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process magnesium ion binding, protein homodimerization activity, ATP binding, caspase activator activity, MAP kinase kinase kinase activity induction of apoptosis by extracellular signals, apoptosis, activation of JUN kinase activity, interspecies interaction between organisms
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	966	AGSNEYLRSISLPVPVLVEDT	MAP3K5	10411906	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.33	-	-

Substrate:	p53 (Cellular tumor antigen p53)
Seq-ID:	P04637 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-13742   CHK2_HUMAN MINT-15878   UBP7_HUMAN MINT-16161   BRCA1_HUMAN MINT-16977   PARP1_HUMAN MINT-19990   PIN1_HUMAN MINT-24859   ASPP2_HUMAN MINT-45889   CEBPZ_HUMAN MINT-49767   ATM_HUMAN MINT-50577   SAE1_HUMAN MINT-56524   SP1_HUMAN MINT-58470   MED1_HUMAN MINT-58672   HNRL1_HUMAN MINT-60094   HIPK2_HUMAN MINT-61312   MK08_HUMAN MINT-61317   WWOX_HUMAN MINT-62206   PP1A_HUMAN MINT-63290   ARI2_HUMAN MINT-63365   KITH_HUMAN MINT-63497   ZNF24_HUMAN MINT-63537   IF2B_HUMAN MINT-63547   RAB4A_HUMAN MINT-63559   SAT1_HUMAN MINT-64119   STX5_HUMAN MINT-64188   MD2BP_HUMAN MINT-64748   K0087_HUMAN MINT-65132   HSPB1_HUMAN MINT-65272   MPH6_HUMAN MINT-68565   BMX_HUMAN MINT-74886   NPM_HUMAN MINT-74925   1433Z_HUMAN MINT-1795431   NMT1_HUMAN MINT-1891378   CDN1A_HUMAN MINT-1958329   CHK1_HUMAN MINT-2634790   RGRF1_HUMAN MINT-2858243   DVL2_HUMAN MINT-2866927   SCAM1_HUMAN MINT-3390028   KC1D_RAT MINT-3979604   P53_MOUSE MINT-4049689   NR4A1_HUMAN MINT-4052116   SYVN1_HUMAN MINT-4052873   GRP78_HUMAN MINT-4302642   HS71L_HUMAN MINT-4303978   XPO1_HUMAN MINT-4329805   TOPRS_HUMAN MINT-4793180   EGR1_HUMAN MINT-4793253   GSK3B_HUMAN MINT-4793489   PML_HUMAN MINT-5114724   ZN363_HUMAN MINT-5207405   HDAC8_HUMAN MINT-6540866   PSME3_HUMAN MINT-6540889   MDM2_HUMAN MINT-6628692   LT_SV40 MINT-6665320   CBP_HUMAN MINT-6701342   MAP1B_HUMAN MINT-7013631   PA1_HUMAN MINT-7013916   RYBP_HUMAN MINT-7103733   ANDR_HUMAN MINT-7144912   TOE1_HUMAN MINT-7222784   FRAP_HUMAN MINT-7263630   EP300_HUMAN MINT-7266250   PLK1_HUMAN MINT-7294020   FAK1_HUMAN MINT-7295816   IKKB_HUMAN MINT-7557644   GRP75_HUMAN MINT-7711943   1433S_HUMAN MINT-7717378   PHB_HUMAN MINT-7718917   SNAI1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process transcription activator activity, protease binding, DNA strand annealing activity, chromatin binding, copper ion binding, ATP binding, transcription factor binding, chaperone binding, zinc ion binding, histone acetyltransferase binding, promoter binding, sequence-specific DNA binding transcription factor activity, protein N-terminus binding, protein heterodimerization activity, protein phosphatase 2A binding, protein kinase binding, ubiquitin protein ligase binding nucleolus, nuclear matrix, insoluble fraction, protein complex, endoplasmic reticulum, PML body, mitochondrion positive regulation of gene-specific transcription from RNA polymerase II promoter, senescence, mitotic cell cycle G1/S DNA damage checkpoint, cell cycle arrest, regulation of mitochondrial membrane permeability, response to gamma radiation, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, response to tumor cell, ER overload response, DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis, interspecies interaction between organisms, Ras protein signal transduction, nucleotide-excision repair, protein tetramerization, cellular response to glucose starvation, negative regulation of helicase activity, negative regulation of cell growth, base-excision repair, activation of caspase activity by cytochrome c, cell aging
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	376	SSHLKSKKGQSTSRHKKLMFK	CDK7	9315650	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.81	-	-
S	378	HLKSKKGQSTSRHKKLMFKTE	CDK7	9315650	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.82	-	-

Substrate:	RGS7 (GTPase activating protein)
Seq-ID:	P49802 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-7252618   PLCG1_HUMAN MINT-7254286   CRK_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process signal transducer activity, protein binding heterotrimeric G-protein complex negative regulation of signal transduction, regulation of G-protein coupled receptor protein signaling pathway, G-protein coupled receptor protein signaling pathway
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	434	EHIYKLMKSDSYPRFIRSSAY	PKC_alpha	12077120	LTP	1.00		YWHAB 14-3-3; YWHAQ 14-3-3	RGS	0.22	2A72	52.46%

Substrate:	Raf1 (RAF proto-oncogene serine/threonine-protein kinase)
Seq-ID:	P04049 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-19324   KPYM_HUMAN MINT-24923   RAP1A_HUMAN MINT-45800   1433Z_HUMAN MINT-51053   K1C19_HUMAN MINT-51055   K1C18_HUMAN MINT-51056   K2C8_HUMAN MINT-56513   CNKR1_HUMAN MINT-3389399   PAK1_HUMAN MINT-3389607   PEBP1_HUMAN MINT-3975386   1433S_HUMAN MINT-6946517   RASH_HUMAN MINT-7014370   MP2K1_HUMAN MINT-7014449   AKT1_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process protein serine/threonine kinase activity, metal ion binding, receptor signaling protein activity, ATP binding, protein binding plasma membrane, cytosol, mitochondrial outer membrane protein amino acid phosphorylation, negative regulation of cell proliferation, apoptosis, Ras protein signal transduction, cell proliferation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	259	GSLSQRQRSTSTPNVHMVSTT	PKA_group	11971957	LTP	1.00	MOD_PKB_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.73	-	medium
S	259	GSLSQRQRSTSTPNVHMVSTT	PKB_group	10576742	LTP	1.00	MOD_PKB_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.73	-	medium
S	259	GSLSQRQRSTSTPNVHMVSTT	-	12801936	LTP	1.00	MOD_PKB_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.73	-	medium
S	259	GSLSQRQRSTSTPNVHMVSTT	-	18220336	HTP	1.00	MOD_PKB_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.73	-	medium
S	259	GSLSQRQRSTSTPNVHMVSTT	-	18669648	HTP	1.00	MOD_PKB_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.73	-	medium
S	621	HSLPKINRSASEPSLHRAAHT	PKA_group	11971957	LTP	0.99		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.49	-	medium
S	621	HSLPKINRSASEPSLHRAAHT	-	9091312	LTP	0.99		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.49	-	medium

Substrate:	WEE 1 tyrosine kinase (Dual specificity kinase)
Seq-ID:	P30291 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-50988   1433B_HUMAN MINT-3295375   1433Z_HUMAN MINT-3975741   1433S_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process magnesium ion binding, protein serine/threonine kinase activity, non-membrane spanning protein tyrosine kinase activity, ATP binding, protein binding nucleoplasm protein amino acid phosphorylation, cell division, mitosis
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	642	LIGKKMNRSVSLTIY	-	15150265	LTP	0.98		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.28	-	medium
S	642	LIGKKMNRSVSLTIY	-	15964826	LTP	0.98		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.28	-	medium

Substrate:	PTPN3 (protein tyrosine phosphatase activity)
Seq-ID:	P26045 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-58311   ADA17_HUMAN MINT-58318   ADA17_MOUSE MINT-3317913   1433Z_HUMAN MINT-3975189   1433S_HUMAN MINT-6797890   GHR_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process protein tyrosine phosphatase activity, cytoskeletal protein binding, phosphotyrosine binding, ATPase binding plasma membrane, cytoplasm, cytoskeleton, extrinsic to membrane protein amino acid dephosphorylation, negative regulation of mitotic cell cycle, negative regulation of membrane protein ectodomain proteolysis
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	359	VWNPAMRRSLSVEHLETKSLP	-	9341175	LTP	1.00		YWHAB 14-3-3	-	0.49	-	-
S	359	VWNPAMRRSLSVEHLETKSLP	-	18669648	HTP	1.00		YWHAB 14-3-3	-	0.49	-	-
S	835	VNYVRSLRVDSEPVLVHCSAG	-	9341175	LTP	0.76		YWHAB 14-3-3	PTPc	0.14	2B49	57.38%

Substrate:	Tristetraproline (tristetraproline (TTP) (TIS11A) (TIS11) (ZFP-36) (from PhosphoBase))
Seq-ID:	P22893 [Mus musculus]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process DNA binding, AU-rich element binding, mRNA binding, zinc ion binding cytosol, nucleus negative regulation of myeloid cell differentiation, negative regulation of inflammatory response, nuclear-transcribed mRNA poly(A) tail shortening, regulation of mRNA stability, positive regulation of nuclear-transcribed mRNA poly(A) tail shortening, RNA destabilization, intracellular protein kinase cascade
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	52	VTSRLTGRSTSLVEGRSCGWV	MAPKAPK2	14688255	LTP	1.00		YWHAB 14-3-3	-	0.45	-	low
S	178	GQPHVLRQSISFSGLPSGRRS	MAPKAPK2	14688255	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAG 14-3-3; YWHAZ 14-3-3	-	0.65	-	low

Substrate:	Tristetraproline (tristetraproline (TTP) (TIS11A) (TIS11) (ZFP-36) (from PhosphoBase))
Seq-ID:	P26651 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process DNA binding, AU-rich element binding, mRNA binding, single-stranded RNA binding, zinc ion binding, protein binding cytosol, nucleus positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	186	GHPPVLRQSISFSGLPSGRRT	-	18669648	HTP	1.00		YWHAB 14-3-3	-	0.66	-	low

Substrate:	Orphan nuclear receptor NR4A1 (Orphan nuclear receptor HMR (Early response protein NAK1) (TR3 orphan receptor))
Seq-ID:	P12813 [Mus musculus]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process sequence-specific DNA binding, protein heterodimerization activity, protein homodimerization activity, transcription activator activity, zinc ion binding, sequence-specific DNA binding transcription factor activity, steroid hormone receptor activity nucleus transcription, negative regulation of caspase activity, induction of apoptosis, positive regulation of transcription from RNA polymerase II promoter
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	354	SLKGRRGRLPSKPKQPPDASP	-	9322922	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.77	1CIT	100.82%

Substrate:	Histone deacetylase 4 (Enzyme: Deacetylase)
Seq-ID:	P56524 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-49703   MEF2A_HUMAN MINT-49706   MEF2C_HUMAN MINT-3296491   1433Z_HUMAN MINT-3975818   1433S_HUMAN MINT-6802058   HIF1A_HUMAN MINT-7144512   ZN148_HUMAN MINT-7299965   BUB1B_HUMAN MINT-7555703   ATF2_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process potassium ion binding, transcription repressor binding, specific transcriptional repressor activity, transcription activator binding, transcription activator activity, histone deacetylase activity, histone deacetylase binding, zinc ion binding histone deacetylase complex, transcriptional repressor complex B cell differentiation, negative regulation of gene-specific transcription from RNA polymerase II promoter, nervous system development, positive regulation of cell proliferation, negative regulation of transcription factor activity, positive regulation of gene-specific transcription from RNA polymerase II promoter, negative regulation of myotube differentiation, transcription, histone H4 deacetylation, positive regulation of transcription factor activity, response to denervation involved in regulation of muscle adaptation, inflammatory response, histone H3 deacetylation, response to interleukin-1, chromatin remodeling, cardiac muscle hypertrophy in response to stress, negative regulation of glycolysis, positive regulation of protein sumoylation, peptidyl-lysine deacetylation, regulation of protein binding
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	246	KDDFPLRKTASEPNLKLRSRL	-	10958686	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.64	-	low
S	246	KDDFPLRKTASEPNLKLRSRL	-	10869435	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.64	-	low
S	467	RQHRPLGRTQSAPLPQNAQAL	CaM-KIV	11470791	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.84	-	low
S	467	RQHRPLGRTQSAPLPQNAQAL	-	18669648	HTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.84	-	low
S	632	GGHRPLSRAQSSPASATFPVS	CaM-KIV	11470791	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.67	-	low
S	632	GGHRPLSRAQSSPASATFPVS	-	18669648	HTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.67	-	low

Substrate:	Kinase suppressor of ras-1 (ATP binding)
Seq-ID:	Q61097 [Mus musculus]
Download:	fasta csv
Interaction Network(s):	-
External Source(s):
MINT Interaction(s):	[show] MINT-13707   1433B_HUMAN MINT-13837   CDC37_HUMAN MINT-14037   HS90B_HUMAN MINT-16002   MP2K1_HUMAN MINT-17370   HSP71_HUMAN MINT-17529   MP2K2_HUMAN MINT-17608   MK03_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process protein serine/threonine kinase activity, metal ion binding, ATP binding, protein binding cytoplasm, membrane protein amino acid phosphorylation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	297	PSFPTLTRSKSHESQLGNRID	-	9858547	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.59	-	medium
S	392	LPLARLRRTESVPSDINNPVD	-	9858547	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.61	-	medium
S	392	LPLARLRRTESVPSDINNPVD	-	12105213	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.61	-	medium

Substrate:	PCTAIRE1 (Serine/threonine-protein kinase PCTAIRE-1)
Seq-ID:	Q00536 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process cyclin-dependent protein kinase activity, ATP binding, protein binding protein amino acid phosphorylation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	119	ISTEDINKRLSLPADIRLPEG	PKA_group	12154078	LTP	0.96	MOD_PKA_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.47	-	medium
S	119	ISTEDINKRLSLPADIRLPEG	-	17192257	HTP	0.96	MOD_PKA_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.47	-	medium
S	153	KPLSRRLRRVSLSEIGFGKLE	PKA_group	12154078	LTP	0.96	MOD_PKA_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.23	-	medium
S	153	KPLSRRLRRVSLSEIGFGKLE	-	17192257	HTP	0.96	MOD_PKA_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.23	-	medium
S	153	KPLSRRLRRVSLSEIGFGKLE	-	18669648	HTP	0.96	MOD_PKA_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.23	-	medium

Substrate:	Pde3a (Enzyme Pphosphodiesterase)
Seq-ID:	Q14432 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	MINT-3295899   1433Z_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process metal ion binding, cGMP-inhibited cyclic-nucleotide phosphodiesterase activity integral to membrane lipid metabolic process, signal transduction
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	428	KLAIPKRLRRSLPPGLLRRVS	-	16964243	HTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.49	-	medium
S	428	KLAIPKRLRRSLPPGLLRRVS	-	18669648	HTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.49	-	medium

Substrate:	Integrin beta 2 (Adhesion molecule)
Seq-ID:	P05107 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-16748   CSN3_HUMAN MINT-45894   SHC1_MOUSE MINT-45897   EPS8_HUMAN MINT-45904   RBGP1_HUMAN MINT-45912   GULP1_HUMAN MINT-45917   NUMB_MOUSE MINT-45924   DAB1_MOUSE MINT-45938   IRS1_RAT MINT-45944   DOK1_MOUSE MINT-45953   TLN1_MOUSE MINT-45956   JIP1_HUMAN MINT-50069   RANB9_HUMAN MINT-4652127   RADI_HUMAN MINT-4652150   CYH1_HUMAN MINT-7226098   ABL1_HUMAN MINT-7226365   TLN2_HUMAN MINT-7226634   VAV_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process receptor activity, protein kinase binding, glycoprotein binding integrin complex apoptosis, integrin-mediated signaling pathway, regulation of cell shape, inflammatory response, cell-cell signaling, neutrophil chemotaxis, cell-matrix adhesion, regulation of peptidyl-tyrosine phosphorylation, leukocyte cell-cell adhesion
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
T	758	NNDNPLFKSATTTVMNPKFAE	PKC_group	11700305	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Integrin_b_cyt	0.35	2JF1	93.15%
T	758	NNDNPLFKSATTTVMNPKFAE	PKC_alpha	11700305	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Integrin_b_cyt	0.35	2JF1	93.15%
T	758	NNDNPLFKSATTTVMNPKFAE	PKC_delta	11700305	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Integrin_b_cyt	0.35	2JF1	93.15%
T	758	NNDNPLFKSATTTVMNPKFAE	PKC_eta	11700305	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Integrin_b_cyt	0.35	2JF1	93.15%
T	758	NNDNPLFKSATTTVMNPKFAE	-	12682249	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Integrin_b_cyt	0.35	2JF1	93.15%

Substrate:	BAD (Bcl2-antagonist of cell death (BAD) (Bcl-2 binding component 6) (Bcl- XL/Bcl-2 associated death promoter) (Bcl-2-like 8 protein))
Seq-ID:	Q61337 [Mus musculus]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process cytosol, mitochondrial outer membrane induction of apoptosis by extracellular signals, glucose homeostasis, cytokine-mediated signaling pathway, apoptosis, positive regulation of B cell differentiation, positive regulation of T cell differentiation, glucose catabolic process, cell proliferation, regulation of caspase activity
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	112	GAMETRSRHSSYPAGTEEDEG	PKB_group	9381178	LTP	1.00	MOD_PKB_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Bcl-2_BAD	0.88	-	medium
S	112	GAMETRSRHSSYPAGTEEDEG	PKB_group	10949026	LTP	1.00	MOD_PKB_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Bcl-2_BAD	0.88	-	medium
S	112	GAMETRSRHSSYPAGTEEDEG	-	15849194	LTP	1.00	MOD_PKB_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Bcl-2_BAD	0.88	-	medium
S	112	GAMETRSRHSSYPAGTEEDEG	RSK_group	10880354	LTP	1.00	MOD_PKB_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Bcl-2_BAD	0.88	-	medium
S	112	GAMETRSRHSSYPAGTEEDEG	-	17242355	HTP	1.00	MOD_PKB_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Bcl-2_BAD	0.88	-	medium
S	112	GAMETRSRHSSYPAGTEEDEG	RSK_group	16103085	LTP	1.00	MOD_PKB_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Bcl-2_BAD	0.88	-	medium
S	112	GAMETRSRHSSYPAGTEEDEG	PKB_group	11983683	LTP	1.00	MOD_PKB_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Bcl-2_BAD	0.88	-	medium
S	136	ELSPFRGRSRSAPPNLWAAQR	PKB_group	9381178	LTP	1.00	MOD_PKB_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Bcl-2_BAD	0.66	-	medium
S	136	ELSPFRGRSRSAPPNLWAAQR	PKB_group	10949026	LTP	1.00	MOD_PKB_1	SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Bcl-2_BAD	0.66	-	medium
S	155	QRYGRELRRMSDEFEGSFKGL	RSK_group	10837486	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Bcl-2_BAD	0.60	-	medium
S	155	QRYGRELRRMSDEFEGSFKGL	-	10837473	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Bcl-2_BAD	0.60	-	medium
S	155	QRYGRELRRMSDEFEGSFKGL	-	15123689	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Bcl-2_BAD	0.60	-	medium
S	155	QRYGRELRRMSDEFEGSFKGL	RSK_group	10880354	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	Bcl-2_BAD	0.60	-	medium

Substrate:	Cytokeratin 18 (Structural protein)
Seq-ID:	P05783 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-51052   1433Z_HUMAN MINT-51055   RAF1_HUMAN MINT-61557   GRB2_HUMAN MINT-67331   EXOC8_HUMAN MINT-68023   HGS_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process structural molecule activity, protein binding centriolar satellite, keratin filament, perinuclear region of cytoplasm negative regulation of apoptosis, anatomical structure morphogenesis, cell cycle, interspecies interaction between organisms, Golgi to plasma membrane CFTR protein transport
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	34	YGARPVSSAASVYAGAGGSGS	-	9524113	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.45	-	low
S	34	YGARPVSSAASVYAGAGGSGS	-	16083285	HTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.45	-	low

Substrate:	B-Raf (B-Raf proto-oncogene serine/threonine-protein kinase)
Seq-ID:	P15056 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-50344   1433B_HUMAN MINT-50372   1433T_HUMAN MINT-2833162   KPCA_HUMAN MINT-2833238   KPCE_HUMAN MINT-2833314   KS6A2_HUMAN MINT-3295552   1433Z_HUMAN MINT-3374124   M3K1_HUMAN MINT-3975375   1433S_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process metal ion binding, ATP binding cytoplasm, nucleus protein amino acid phosphorylation, organ morphogenesis, anti-apoptosis, small GTPase mediated signal transduction
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	365	NQFGQRDRSSSAPNVHINTIE	PKB_group	10869359	LTP	1.00	MOD_PKB_1	YWHAB 14-3-3	-	0.74	-	-
S	365	NQFGQRDRSSSAPNVHINTIE	PKB_group	11410590	LTP	1.00	MOD_PKB_1	YWHAB 14-3-3	-	0.74	-	-
S	365	NQFGQRDRSSSAPNVHINTIE	SGK_group	11410590	LTP	1.00	MOD_PKB_1	YWHAB 14-3-3	-	0.74	-	-
S	365	NQFGQRDRSSSAPNVHINTIE	-	17192257	HTP	1.00	MOD_PKB_1	YWHAB 14-3-3	-	0.74	-	-
S	365	NQFGQRDRSSSAPNVHINTIE	-	18220336	HTP	1.00	MOD_PKB_1	YWHAB 14-3-3	-	0.74	-	-
S	365	NQFGQRDRSSSAPNVHINTIE	-	18669648	HTP	1.00	MOD_PKB_1	YWHAB 14-3-3	-	0.74	-	-
S	729	RSLPKIHRSASEPSLNRAGFQ	-	17192257	HTP	0.98		YWHAB 14-3-3	-	0.41	-	-
S	729	RSLPKIHRSASEPSLNRAGFQ	-	18669648	HTP	0.98		YWHAB 14-3-3	-	0.41	-	-

Substrate:	cdc25c (M-phase inducer phosphatase 3)
Seq-ID:	P30307 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-16690   PLK1_HUMAN MINT-3294433   1433Z_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process protein tyrosine phosphatase activity, WW domain binding cytosol, nucleoplasm regulation of cyclin-dependent protein kinase activity, cell division, traversing start control point of mitotic cell cycle, protein amino acid dephosphorylation, regulation of mitosis, mitosis, interspecies interaction between organisms, DNA replication, cell proliferation
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	216	VSRSGLYRSPSMPENLNRPRL	CHK2	10744722	LTP	0.98		CDC25C 14-3-3; NPHP1 14-3-3; SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	M-inducer_phosp	0.66	-	low
S	216	VSRSGLYRSPSMPENLNRPRL	-	15629715	LTP	0.98		CDC25C 14-3-3; NPHP1 14-3-3; SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	M-inducer_phosp	0.66	-	low
S	216	VSRSGLYRSPSMPENLNRPRL	CHK2	9836640	LTP	0.98		CDC25C 14-3-3; NPHP1 14-3-3; SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	M-inducer_phosp	0.66	-	low
S	216	VSRSGLYRSPSMPENLNRPRL	BRSK1	9543386	LTP	0.98		CDC25C 14-3-3; NPHP1 14-3-3; SFN 14-3-3; YWHAB 14-3-3; YWHAE 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	M-inducer_phosp	0.66	-	low

Substrate:	HDAC5 (histone deacetylase activity, specific transcriptional repressor activity)
Seq-ID:	Q9UQL6 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	[show] MINT-65796   EF1G_HUMAN MINT-3318337   1433Z_HUMAN MINT-6802102   HIF1A_HUMAN MINT-7299978   BUB1B_HUMAN MINT-7710106   PKN2_HUMAN
GO-Terms:	[show] Molecular Function Cellular Component Biological Process protein kinase C binding, transcription repressor binding, specific transcriptional repressor activity, histone deacetylase activity, transcription factor binding histone deacetylase complex, cytoplasm B cell differentiation, negative regulation of gene-specific transcription from RNA polymerase II promoter, positive regulation of gene-specific transcription from RNA polymerase II promoter, negative regulation of myotube differentiation, transcription, histone deacetylation, positive regulation of transcription factor activity, chromatin silencing, inflammatory response, negative regulation of cell migration involved in sprouting angiogenesis, chromatin remodeling, cellular response to insulin stimulus, regulation of protein binding
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	259	RDDFPLRKTASEPNLKVRSRL	CaM-KIV	11081517	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.69	-	medium
S	498	PRHRPLSRTQSSPLPQSPQAL	CaM-KIV	11081517	LTP	1.00		SFN 14-3-3; YWHAB 14-3-3; YWHAG 14-3-3; YWHAH 14-3-3; YWHAQ 14-3-3; YWHAZ 14-3-3	-	0.88	-	medium

Substrate:	Phosphodiesterase 3B (Enzyme: Phosphodiesterase)
Seq-ID:	Q13370 [Homo sapiens]
Download:	fasta csv
Interaction Network(s):
External Source(s):
MINT Interaction(s):	-
GO-Terms:	[show] Molecular Function Cellular Component Biological Process protein kinase B binding, metal ion binding, cGMP-inhibited cyclic-nucleotide phosphodiesterase activity guanyl-nucleotide exchange factor complex, microsome, integral to membrane, Golgi apparatus, endoplasmic reticulum cAMP catabolic process, signal transduction, negative regulation of cell adhesion mediated by integrin, negative regulation of cAMP-mediated signaling, cellular response to insulin stimulus, negative regulation of lipid catabolic process
Conservation:
Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
S	318	YGSCKIFRRPSLPCISREQMI	PKA_group	8626720	LTP	1.00	MOD_PKA_1	YWHAB 14-3-3	-	0.05	-	medium
S	318	YGSCKIFRRPSLPCISREQMI	-	8163498	LTP	1.00	MOD_PKA_1	YWHAB 14-3-3	-	0.05	-	medium
S	318	YGSCKIFRRPSLPCISREQMI	PKA_group	17255105	LTP	1.00	MOD_PKA_1	YWHAB 14-3-3	-	0.05	-	medium