List of substrates found:


Substrate: Alpha-synuclein (Chaperone)
Seq-ID: P37840 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-2515544   VIME_HUMAN
MINT-3387974   TPPP_HUMAN
MINT-7555062   HSP71_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
histone binding,
ferrous iron binding,
phospholipase binding,
caspase inhibitor activity,
dynein binding,
alpha-tubulin binding,
zinc ion binding,
Hsp70 protein binding,
kinesin binding,
magnesium ion binding,
calcium ion binding,
tau protein binding		 plasma membrane,
cytosol,
nucleus,
axon,
actin cytoskeleton,
cell cortex,
growth cone,
fibril		 response to magnesium ion,
positive regulation of release of sequestered calcium ion into cytosol,
response to interferon-gamma,
regulation of phospholipase activity,
negative regulation of platelet-derived growth factor receptor signaling pathway,
positive regulation of inositol phosphate biosynthetic process,
response to interleukin-1,
response to iron(II) ion,
synaptic vesicle endocytosis,
negative regulation of monooxygenase activity,
positive regulation of receptor recycling,
response to lipopolysaccharide,
negative regulation of norepinephrine uptake,
negative regulation of exocytosis,
negative regulation of histone acetylation,
negative regulation of serotonin uptake,
receptor internalization,
cell death,
negative regulation of dopamine uptake,
negative regulation of transporter activity,
negative regulation of thrombin receptor signaling pathway,
positive regulation of endocytosis,
anti-apoptosis,
negative regulation of caspase activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 125 DMPVDPDNEAYEMPSEEGYQD Fyn 11162638
LTP
0.26
 - Synuclein
0.82
 --

Substrate: Beta-catenin (Adhesion molecule)
Seq-ID: P35222 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-46005   CADH1_HUMAN
MINT-46006   CTNA1_HUMAN
MINT-49803   ANDR_HUMAN
MINT-49805   NCOA2_HUMAN
MINT-1779698   TF7L2_HUMAN
MINT-1792780   LAP2_HUMAN
MINT-1792796   PKP4_HUMAN
MINT-2839028   LAP2B_HUMAN
MINT-2839079   EMD_HUMAN
MINT-4085223   CADH5_HUMAN
MINT-4085261   PARD3_HUMAN
MINT-4085491   CADH2_HUMAN
MINT-4508051   GSK3B_HUMAN
MINT-4508065   ITF2_HUMAN
MINT-4508192   AXN1_HUMAN
MINT-4508216   ABL1_HUMAN
MINT-4508229   APC_HUMAN
MINT-6823807   HDAC1_HUMAN
MINT-7023862   NFKB1_HUMAN
MINT-7952417   TNIK_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
R-SMAD binding,
cadherin binding,
androgen receptor binding,
alpha-catenin binding,
kinase binding,
protein phosphatase binding,
transcription coactivator activity,
promoter binding,
signal transducer activity,
estrogen receptor binding,
I-SMAD binding,
protein C-terminus binding		 Axin-APC-beta-catenin-GSK3B complex,
catenin complex,
transcription factor complex,
perinuclear region of cytoplasm,
cell cortex,
protein-DNA complex,
beta-catenin-TCF7L2 complex,
centrosome,
cell-substrate adherens junction,
lateral plasma membrane		 positive regulation of gene-specific transcription from RNA polymerase II promoter,
patterning of blood vessels,
protein localization at cell surface,
positive regulation of heparan sulfate proteoglycan biosynthetic process,
negative regulation of cell proliferation,
cellular response to indole-3-methanol,
response to drug,
positive regulation of anti-apoptosis,
positive regulation of apoptosis,
canonical Wnt receptor signaling pathway,
regulation of calcium ion import,
androgen receptor signaling pathway,
adherens junction assembly,
regulation of fibroblast proliferation,
epithelial to mesenchymal transition,
regulation of smooth muscle cell proliferation,
cell-cell adhesion,
cellular response to growth factor stimulus,
positive regulation of epithelial to mesenchymal transition,
regulation of angiogenesis,
endothelial tube morphogenesis,
negative regulation of apoptosis,
transcription,
regulation of centriole-centriole cohesion,
regulation of centromeric sister chromatid cohesion,
response to estradiol stimulus
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 142 LKHAVVNLINYQDDAELATRA Fyn 12640114
LTP
0.94
 - ARM
0.32
 1G3J 74.24%

Substrate: c-kit (Receptor tyrosine kinase)
Seq-ID: P05532 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
stem cell factor receptor activity,
ATP binding,
protein binding		 external side of plasma membrane,
integral to membrane		 positive regulation of cell proliferation,
spermatid development,
cytokine-mediated signaling pathway,
germ cell programmed cell death,
regulation of developmental pigmentation,
response to radiation,
protein amino acid autophosphorylation,
chemotaxis,
myeloid progenitor cell differentiation,
negative regulation of programmed cell death,
transmembrane receptor protein tyrosine kinase signaling pathway,
peptidyl-tyrosine phosphorylation,
developmental pigmentation,
myeloid leukocyte differentiation,
glycosphingolipid metabolic process,
lymphoid progenitor cell differentiation,
positive regulation of MAP kinase activity,
cell proliferation,
intracellular protein kinase cascade,
positive regulation of gene expression
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 934 KQISDSTKHIYSNLANCNPNP Fyn N.N.
LTP
1.00
 - -
0.42
 - medium
Y 934 KQISDSTKHIYSNLANCNPNP Fyn 12374739
LTP
1.00
 - -
0.42
 - medium

Substrate: Caveolin-1 (May act as a scaffolding protein within the caveolar membranes )
Seq-ID: Q03135 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14113   RASH_HUMAN
MINT-15459   SRC_HUMAN
MINT-50920   MDR1_HUMAN
MINT-6764866   PTN1_HUMAN
MINT-6793815   PTN6_HUMAN
MINT-6793823   PTEN_HUMAN
MINT-6793881   PTN11_HUMAN
MINT-7234712   SDPR_HUMAN
MINT-7234742   PRDBP_HUMAN
MINT-7307629   TRXR1_HUMAN
MINT-7309906   SCRB2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
nitric-oxide synthase binding,
protein complex scaffold,
cholesterol binding,
peptidase activator activity,
receptor binding,
protein binding		 lipid particle,
basolateral plasma membrane,
caveola,
perinuclear region of cytoplasm,
apical plasma membrane,
endoplasmic reticulum,
Golgi membrane		 cellular response to starvation,
negative regulation of gene-specific transcription from RNA polymerase II promoter,
positive regulation of vasoconstriction,
inactivation of MAPK activity,
maintenance of protein location in cell,
regulation of blood coagulation,
negative regulation of BMP signaling pathway,
cholesterol homeostasis,
positive regulation of calcium ion transport into cytosol,
lipid storage,
mammary gland involution,
positive regulation of peptidyl-serine phosphorylation,
negative regulation of canonical Wnt receptor signaling pathway,
negative regulation of epithelial cell differentiation,
positive regulation of metalloenzyme activity,
negative regulation of peptidyl-serine phosphorylation,
calcium ion transport,
interspecies interaction between organisms,
cytosolic calcium ion homeostasis,
T cell costimulation,
triglyceride metabolic process,
protein homooligomerization,
vesicle organization,
negative regulation of endothelial cell proliferation,
nitric oxide homeostasis,
receptor internalization,
caveola assembly,
regulation of smooth muscle contraction,
membrane depolarization,
regulation of fatty acid metabolic process,
response to hypoxia,
response to estrogen stimulus,
positive regulation of canonical Wnt receptor signaling pathway,
response to progesterone stimulus,
negative regulation of nitric oxide biosynthetic process,
response to calcium ion,
negative regulation of MAPKKK cascade,
negative regulation of protein binding,
vasculogenesis,
skeletal muscle tissue development
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 14 GKYVDSEGHLYTVPIREQGNI Fyn 12921535
LTP
0.69
 Csk SH2 Caveolin
0.29
 - low

Substrate: CBL E3 ubiquitin protein ligase (Adaptor molecule)
Seq-ID: P22681 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-15516   LCK_HUMAN
MINT-15716   CRK_HUMAN
MINT-16022   CD2AP_HUMAN
MINT-16347   LYN_HUMAN
MINT-16846   LCP2_HUMAN
MINT-17062   FCGR1_HUMAN
MINT-17932   NCK1_HUMAN
MINT-50666   FYN_HUMAN
MINT-50717   ABL1_HUMAN
MINT-50722   CRKL_HUMAN
MINT-58331   ITCH_HUMAN
MINT-60970   RET_HUMAN
MINT-60973   EGFR_HUMAN
MINT-60978   SHC1_HUMAN
MINT-68500   P85A_HUMAN
MINT-2837344   PLCG1_BOVIN
MINT-4299918   ASAP1_HUMAN
MINT-6169713   SPY1_HUMAN
MINT-6170244   SH3G2_HUMAN
MINT-6538940   SPY4_HUMAN
MINT-6538977   KSYK_HUMAN
MINT-6539587   MET_HUMAN
MINT-6539601   SPY2_HUMAN
MINT-6539646   VGFR1_HUMAN
MINT-6539679   RON_HUMAN
MINT-6539730   SRC_HUMAN
MINT-7040249   GRB2_HUMAN
MINT-7046364   ITSN1_HUMAN
MINT-7103623   MK08_HUMAN
MINT-7211864   ARHG7_HUMAN
MINT-7214822   FYN_MOUSE
MINT-7218352   SH3K1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
SH3 domain binding,
calcium ion binding,
zinc ion binding,
sequence-specific DNA binding transcription factor activity,
signal transducer activity,
ubiquitin-protein ligase activity		 cytosol,
nucleus		 epidermal growth factor receptor signaling pathway,
positive regulation of receptor-mediated endocytosis
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 700 EQCEGEEDTEYMTPSSRPLRP Fyn 9525940
LTP
0.63
 CRKL SH2;
CRK SH2;
PIK3R2 SH2;
PLCG1 SH2;
VAV_group SH2		 -
0.85
 --
Y 731 DCDQQIDSCTYEAMYNIQSQA Fyn 9525940
LTP
0.29
 CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2		 -
0.47
 --
Y 731 DCDQQIDSCTYEAMYNIQSQA Fyn 9890970
LTP
0.29
 CRKL SH2;
CRK SH2;
Lyn SH2;
PIK3R1 SH2;
PIK3R2 SH2;
PLCG1 SH2		 -
0.47
 --
Y 774 PEESENEDDGYDVPKPPVPAV Fyn 9525940
LTP
0.28
 CRKL SH2;
CRK SH2;
PLCG1 SH2		 -
0.89
 --

Substrate: CD150 (T cell antigen receptor)
Seq-ID: Q13291 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
antigen binding,
transmembrane receptor activity		 integral to membrane positive regulation of cell proliferation,
lymphocyte activation,
interspecies interaction between organisms
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 281 TTVEKKSLTIYAQVQKPGPLQ Fyn 11806999
LTP
1.00
 FGR SH2;
INPP5D SH2;
PTPN11 SH2;
SH2D1A SH2;
SH2D1B SH2		 -
0.39
 - low
Y 307 FPAQDPCTTIYVAATEPVPES Fyn 11806999
LTP
1.00
 INPP5D SH2;
PTPN11 SH2;
SH2D1A SH2;
SH2D1B SH2		 -
0.40
 - low
Y 327 SVQETNSITVYASVTLPES   Fyn 11806999
LTP
1.00
 FGR SH2;
INPP5D SH2;
PTPN11 SH2;
SH2D1A SH2;
SH2D1B SH2		 -
0.38
 - low

Substrate: CD3 zeta (T-cell surface glycoprotein CD3 zeta chain precursor (from PhosphoBase))
Seq-ID: P20963 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-60782   LCK_HUMAN
MINT-7301967   NCK1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein homodimerization activity,
transmembrane receptor activity		 cytoplasm,
integral to membrane		 interspecies interaction between organisms
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 111 QRRKNPQEGLYNELQKDKMAE Fyn 8578591
LTP
1.00
 LIG_TYR_ITAM
 Fyn SH2;
Lck SH2;
SHC1 SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.63
 - medium
Y 123 ELQKDKMAEAYSEIGMKGERR Fyn 8578591
LTP
1.00
 LIG_TYR_ITAM
 Lck SH2;
SYK SH2;
ZAP70 SH2		 ITAM
0.49
 - medium

Substrate: CD32 (CD antigen. Binds to the Fc region of immunoglobulins gamma.)
Seq-ID: P12318 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
receptor activity,
IgG binding		 plasma membrane,
integral to membrane
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 281 KRQLEETNNDYETADGGYMTL Fyn 8756631
LTP
1.00
 - -
0.57
 - low
Y 288 NNDYETADGGYMTLNPRAPTD Fyn 8756631
LTP
0.46
 LIG_TYR_ITAM
 - -
0.66
 - low
Y 304 RAPTDDDKNIYLTLPPNDHVN Fyn 8756631
LTP
0.08
 LIG_TYR_ITAM
 - -
0.66
 - low

Substrate: CD79A (B cell antigen receptor)
Seq-ID: P11912 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transmembrane receptor activity B cell receptor complex,
external side of plasma membrane,
integral to membrane,
multivesicular body,
membrane raft		 B cell differentiation,
B cell receptor signaling pathway,
B cell proliferation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 199 EGLNLDDCSMYEDISRGLQGT Fyn 9531288
LTP
1.00
 LIG_TYR_ITAM
 BLK SH2;
SHC1 SH2		 ITAM
0.26
 - low

Substrate: CD79B (B cell antigen receptor)
Seq-ID: P40259 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
transmembrane receptor activity integral to plasma membrane immune response,
cell surface receptor linked signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 196 SKAGMEEDHTYEGLDIDQTAT Fyn 9531288
LTP
 - LIG_TYR_ITAM
 BLK SH2 ITAM
0.48
 - medium
Y 207 EGLDIDQTATYEDIVTLRTGE Fyn 9531288
LTP
 - LIG_TYR_ITAM
 BLK SH2 ITAM
0.23
 - medium

Substrate: FYN (Cytoplasmic tyrosine kinase)
Seq-ID: P06241 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-14847   WASP_HUMAN
MINT-15132   HNRPK_RAT
MINT-15408   KHDR1_HUMAN
MINT-15425   SHC1_HUMAN
MINT-16566   FYB_HUMAN
MINT-46000   CTNB1_MOUSE
MINT-50377   RASH_HUMAN
MINT-50652   MAP2_HUMAN
MINT-50666   CBL_HUMAN
MINT-61277   G3BP1_HUMAN
MINT-61574   CTNB1_RAT
MINT-2792095   PAK2_HUMAN
MINT-2792412   ADA15_HUMAN
MINT-2859062   ATX1_HUMAN
MINT-3381335   VGFR2_HUMAN
MINT-3381360   SRC_HUMAN
MINT-3381384   NCK1_HUMAN
MINT-4085360   TNR6_HUMAN
MINT-7214580   5HT6R_HUMAN
MINT-7245838   TRI39_HUMAN
MINT-7245886   ORC1_HUMAN
MINT-7245898   AKAP6_HUMAN
MINT-7245910   CENPA_HUMAN
MINT-7245922   LRBA_HUMAN
MINT-7245934   TRAIP_HUMAN
MINT-7245958   RPP38_HUMAN
MINT-7245970   HCN2_HUMAN
MINT-7246030   ASAP2_HUMAN
MINT-7246102   SYNJ2_HUMAN
MINT-7246150   RIMS1_HUMAN
MINT-7246210   DLGP4_HUMAN
MINT-7246222   LAP2B_HUMAN
MINT-7246246   TGON2_HUMAN
MINT-7246270   EPS15_HUMAN
MINT-7246306   CD2AP_HUMAN
MINT-7246318   MLL4_HUMAN
MINT-7246402   ARHGB_HUMAN
MINT-7246426   FLNC_HUMAN
MINT-7246450   SP1_HUMAN
MINT-7246474   RIMS2_HUMAN
MINT-7246522   ABL1_HUMAN
MINT-7246534   SNX12_HUMAN
MINT-7246558   M4K1_HUMAN
MINT-7246570   PRIC3_HUMAN
MINT-7246594   WNK2_HUMAN
MINT-7246630   RTN4_HUMAN
MINT-7246666   SF3B4_HUMAN
MINT-7246678   NFASC_HUMAN
MINT-7246714   GCF_HUMAN
MINT-7246726   PPR3D_HUMAN
MINT-7246750   BAZ2A_HUMAN
MINT-7246774   KI67_HUMAN
MINT-7246798   DDX41_HUMAN
MINT-7246810   DPOD1_HUMAN
MINT-7246834   FLNA_HUMAN
MINT-7246846   CDC27_HUMAN
MINT-7246870   SNX8_HUMAN
MINT-7246882   ABL2_HUMAN
MINT-7246918   ASAP1_HUMAN
MINT-7246930   MED14_HUMAN
MINT-7246954   WIPF1_HUMAN
MINT-7246978   E41L3_HUMAN
MINT-7247002   BCAR1_HUMAN
MINT-7247014   MYPT1_HUMAN
MINT-7247038   CAF1A_HUMAN
MINT-7247050   SHRM2_HUMAN
MINT-7247074   VP13A_HUMAN
MINT-7247086   CDKL5_HUMAN
MINT-7247098   ICAL_HUMAN
MINT-7247122   RRAS_HUMAN
MINT-7247134   NELFB_HUMAN
MINT-7247146   SPN90_HUMAN
MINT-7247158   CKAP5_HUMAN
MINT-7247170   FANCA_HUMAN
MINT-7247182   HDAC6_HUMAN
MINT-7247194   SNX3_HUMAN
MINT-7247206   BRPF3_HUMAN
MINT-7247230   XRCC1_HUMAN
MINT-7247242   DAB2_HUMAN
MINT-7247254   M4K5_HUMAN
MINT-7247290   STF1_HUMAN
MINT-7247302   DOCK1_HUMAN
MINT-7247350   BRCA2_HUMAN
MINT-7247374   RPGF1_HUMAN
MINT-7247422   DAG1_HUMAN
MINT-7247434   SUV92_HUMAN
MINT-7247446   FCG2B_HUMAN
MINT-7247458   FCG2C_HUMAN
MINT-7247482   CELR3_HUMAN
MINT-7247530   SOS1_HUMAN
MINT-7247554   MOS_HUMAN
MINT-7247566   SNX17_HUMAN
MINT-7306611   LCP2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
identical protein binding,
metal ion binding,
glycoprotein binding,
non-membrane spanning protein tyrosine kinase activity,
ATP binding		 plasma membrane,
endosome,
cytosol		 learning,
feeding behavior,
calcium ion transport,
interspecies interaction between organisms,
T cell receptor signaling pathway,
intracellular protein kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 28 RDGSLNQSSGYRYGTDPTPQH Fyn 9425276
LTP
0.06
 - -
0.68
 --
Y 30 GSLNQSSGYRYGTDPTPQHYP Fyn 9425276
LTP
0.56
 - -
0.61
 --
Y 39 RYGTDPTPQHYPSFGVTSIPN Fyn 9425276
LTP
0.19
 - -
0.52
 --
Y 420 GLARLIEDNEYTARQGAKFPI Fyn 1985196
LTP
1.00
 - TyrKc
0.16
 2DQ7 44.98%

Substrate: FYN-binding protein (Adaptor molecule)
Seq-ID: O15117 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-15244   LCP2_HUMAN
MINT-16566   FYN_HUMAN
MINT-7147875   SKAP1_HUMAN
MINT-7244566   ABL1_HUMAN
MINT-7250710   NCK1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein binding cytoplasm,
nucleus		 protein amino acid phosphorylation,
NLS-bearing substrate import into nucleus,
immune response,
intracellular protein kinase cascade
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 595 SRPIEDDQEVYDDVAEQDDIS Fyn 10570256
LTP
1.00
 LCP2 SH2 -
0.75
 --
Y 595 SRPIEDDQEVYDDVAEQDDIS Fyn 10409671
LTP
1.00
 LCP2 SH2 -
0.75
 --
Y 651 PKQLDMGDEVYDDVDTSDFPV Fyn 10570256
LTP
1.00
 LCP2 SH2 -
0.63
 --
Y 651 PKQLDMGDEVYDDVDTSDFPV Fyn 10409671
LTP
1.00
 LCP2 SH2 -
0.63
 --

Substrate: Glutamate [NMDA] receptor subunit epsilon 2 (Extracellular ligand gated channel)
Seq-ID: Q01097 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-50181   NMDZ1_MOUSE
MINT-2778712   KCC2A_MOUSE
MINT-2778742   AP2A1_MOUSE
MINT-6504956   DLG4_MOUSE
MINT-7975079   DLG4_RAT
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
calcium channel activity,
N-methyl-D-aspartate selective glutamate receptor activity,
zinc ion binding		 N-methyl-D-aspartate selective glutamate receptor complex,
cell junction,
presynaptic membrane,
outer membrane-bounded periplasmic space,
synaptic vesicle,
synaptosome,
postsynaptic membrane,
postsynaptic density		 suckling behavior,
behavioral response to pain,
in utero embryonic development,
startle response,
sensory organ development,
behavioral fear response,
memory,
detection of mechanical stimulus involved in sensory perception of pain,
regulation of excitatory postsynaptic membrane potential,
response to ethanol
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 932 LDFIRRESSVYDISEHRRSFT Fyn 11024032
LTP
0.20
 - NMDAR2_C
0.31
 - medium
Y 1039 SSKHSQLSDLYGKFSFKSDRY Fyn 11024032
LTP
0.18
 - NMDAR2_C
0.40
 - medium
Y 1070 VSDISTHTVTYGNIEGNAAKR Fyn 11024032
LTP
1.00
 - NMDAR2_C
0.58
 - medium
Y 1109 RREFDEIELAYRRRPPRSPDH Fyn 11024032
LTP
1.00
 - NMDAR2_C
0.60
 - medium
Y 1252 CEACKKAGNLYDISEDNSLQE Fyn 11024032
LTP
1.00
 - NMDAR2_C
0.38
 - medium
Y 1336 DKGRFMDGSPYAHMFEMPAGE Fyn 11024032
LTP
0.59
 - NMDAR2_C
0.48
 - medium
Y 1472 AFNGSSNGHVYEKLSSIESDV Fyn 12451687
LTP
1.00
 - NMDAR2_C
0.44
 - medium
Y 1472 AFNGSSNGHVYEKLSSIESDV Fyn 11024032
LTP
1.00
 - NMDAR2_C
0.44
 - medium

Substrate: Grb10 (Adapter molecule)
Seq-ID: Q13322 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-15644   IGF1R_HUMAN
MINT-16516   INSR_HUMAN
MINT-16802   EGFR_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
insulin receptor binding,
SH3/SH2 adaptor activity		 plasma membrane,
cytoplasm		 negative regulation of glycogen biosynthetic process,
negative regulation of insulin receptor signaling pathway,
negative regulation of glucose import,
positive regulation of vascular endothelial growth factor receptor signaling pathway,
negative regulation of Wnt receptor signaling pathway,
insulin receptor signaling pathway,
positive regulation of phosphorylation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 67 NDMNASLESLYSACSMQSDTV Fyn 10871840
LTP
0.81
 Fyn SH2;
Src SH2		 -
0.50
 - low

Substrate: Hic-5 (Androgen receptor binding)
Seq-ID: O43294 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-61742   HIPK3_HUMAN
MINT-2863575   UBQL4_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
I-SMAD binding,
androgen receptor binding,
transcription coactivator activity,
zinc ion binding,
Roundabout binding		 focal adhesion,
cytoplasm,
cytoskeleton,
nuclear matrix		 ubiquitin-dependent SMAD protein catabolic process,
transcription from RNA polymerase II promoter,
negative regulation of cell proliferation,
negative regulation of transforming growth factor beta receptor signaling pathway,
positive regulation of transcription, DNA-dependent,
Wnt receptor signaling pathway,
positive regulation of transforming growth factor beta receptor signaling pathway,
androgen receptor signaling pathway,
cell adhesion,
positive regulation of epithelial to mesenchymal transition
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 60 SGASGDKDHLYSTVCKPRSPK Fyn 10838081
LTP
0.08
 - -
0.75
 - medium

Substrate: Inositol 1,4,5-trisphosphate receptor type 1 (inositol 1,4,5-trisphosphate-binding protein type 1 receptor (from PhosphoBase))
Seq-ID: Q14643 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity,
calcium ion transmembrane transporter activity,
protein binding		 platelet dense tubular network membrane,
integral to membrane,
endoplasmic reticulum membrane,
platelet dense granule membrane		 response to hypoxia,
cell death
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 353 RLRNAQEKMVYSLVSVPEGND Fyn 14761954
LTP
0.95
 - MIR
0.41
 1N4K 29.26%

Substrate: ITCH (protein binding, ubiquitin-protein ligase activity)
Seq-ID: Q96J02 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19902   SH3G2_HUMAN
MINT-50139   CASL_HUMAN
MINT-58329   CBLC_HUMAN
MINT-58331   CBL_HUMAN
MINT-2881316   SGK3_HUMAN
MINT-3389173   P73_HUMAN
MINT-4050151   TRPV4_MOUSE
MINT-7542986   BID_MOUSE
MINT-7889719   SNX18_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
ribonucleoprotein binding,
CXCR chemokine receptor binding,
ubiquitin-protein ligase activity		 plasma membrane,
nucleus		 regulation of cell growth,
negative regulation of apoptosis,
apoptosis,
negative regulation of defense response to virus,
inflammatory response,
innate immune response,
protein K48-linked ubiquitination,
protein K63-linked ubiquitination,
entry of virus into host cell,
protein K29-linked ubiquitination,
response to virus
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 420 AMQQFNQRFIYGNQDLFATSQ Fyn 16387660
LTP
0.96
 - -
0.39
 - low

Substrate: LAMP (Unclassified)
Seq-ID: Q91GT2 [Human herpesvirus 8]
Download:fasta csv
Interaction Network(s): -
External Source(s):
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 480 QAATQPTDDLYEEVLFPRN   Fyn 12915550
LTP
 - - Herpes_LAMP2
0.68
 - low

Substrate: Microtubule associated protein 2 (Cytoskeletal protein)
Seq-ID: P11137 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-50652   FYN_HUMAN
MINT-50656   GRB2_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
beta-dystroglycan binding,
structural molecule activity,
calmodulin binding		 cytoplasm,
microtubule associated complex,
microtubule		 negative regulation of microtubule depolymerization
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 67 AFGEHGSQGTYSNTKENGING Fyn 15536091
LTP
1.00
 GRB2 SH2 -
0.85
 - medium

Substrate: NMT1 (Unclassified)
Seq-ID: P30419 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-1795337   CAN2_HUMAN
MINT-1795431   P53_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
glycylpeptide N-tetradecanoyltransferase activity cytosol protein lipoylation,
N-terminal protein myristoylation
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 180 KELYTLLNENYVEDDDNMFRF Fyn 11594778
LTP
1.00
 - NMT
0.13
 1RXT 25.33%

Substrate: PLC gamma 2 (Involved in transmembrane signaling)
Seq-ID: P16885 [Homo sapiens]
Download:fasta csv
Interaction Network(s): NetworKIN
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-60791   Z512B_HUMAN
MINT-74685   EGFR_HUMAN
MINT-74686   ERBB2_HUMAN
MINT-7252126   P85A_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoinositide phospholipase C activity,
signal transducer activity,
protein binding		 plasma membrane phospholipid catabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 743 YPVTPELLERYNMERDINSLY Fyn 12181444
LTP
0.05
 - -
0.27
 - medium

Substrate: PLD2 (Phospholipase D2)
Seq-ID: P97813 [Mus musculus]
Download:fasta csv
Interaction Network(s): STRING  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
NAPE-specific phospholipase D activity,
phosphoinositide binding,
phospholipase D activity,
protein binding		 brush border membrane cell communication,
G-protein coupled receptor internalization,
lipid catabolic process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 11 MTVTQKNLFPYGDYLNSSQLH Fyn 15282299
LTP
0.00
 - -
0.30
 - medium
Y 14 TQKNLFPYGDYLNSSQLHMEP Fyn 15282299
LTP
0.00
 - -
0.34
 - medium
Y 165 SARHTASKQKYLENYLNRLLT Fyn 15282299
LTP
0.31
 - PX
0.23
 - medium
Y 470 LAFGRWDDVQYRLTDLGDPSE Fyn 15282299
LTP
0.28
 - -
0.20
 - medium

Substrate: Postsynaptic density protein PSD-93 (Required for perception of chronic pain through NMDA receptor signaling)
Seq-ID: Q63622 [Rattus norvegicus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-60072   NMDE2_RAT
MINT-72861   SHAN1_RAT
MINT-72877   DLG4_RAT
MINT-73075   AT2B2_HUMAN
MINT-73076   AT2B4_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein heterodimerization activity,
protein C-terminus binding,
PDZ domain binding		 membrane fraction,
cell junction,
postsynaptic membrane,
postsynaptic density		 receptor clustering,
neuronal ion channel clustering
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 348 DDYTRPPEPVYSTVNKLCDKP Fyn 13129934
LTP
 - - -
0.56
 --

Substrate: Postsynaptic density protein PSD-93 (Required for perception of chronic pain through NMDA receptor signaling)
Seq-ID: Q91XM9 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
MINT-50218   NMDZ1_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
protein binding cell junction,
postsynaptic membrane,
postsynaptic density		 sensory perception of pain,
synaptic transmission
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 348 DDYTRPPEPVYSTVNKLCDKP Fyn 13129934
LTP
 - - -
0.58
 --

Substrate: SCAP1 (protein binding, protein-tyrosine kinase activity)
Seq-ID: Q86WV1 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):
MINT-7147875   FYB_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
antigen binding,
protein kinase binding,
transcription activator activity,
SH3/SH2 adaptor activity,
SH2 domain binding		 plasma membrane,
cytoplasm,
nucleus		 T cell receptor signaling pathway,
positive regulation of transcription from RNA polymerase II promoter
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 219 LKDLSSLTIPYEEDEEEEEKE Fyn 11909961
LTP
0.78
 - -
0.59
 --
Y 232 DEEEEEKEETYDDIDGFDSPS Fyn 11909961
LTP
1.00
 - -
0.73
 --

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