Phospho.ELM Result

a database of S/T/Y phosphorylation sites

Statistics:
	Instances	42.914
	Kinases	299
	References	3.657
	Sequences	11.224
	Substrates	8.698

List of substrates found:

Substrate:

CD150 (T cell antigen receptor)

Seq-ID:

Q13291 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
antigen binding, transmembrane receptor activity	integral to membrane	positive regulation of cell proliferation, lymphocyte activation, interspecies interaction between organisms

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	307	FPAQDPCTTIYVAATEPVPES	Lck	11806999	LTP	1.00		INPP5D SH2; PTPN11 SH2; SH2D1A SH2; SH2D1B SH2	-	0.40	-	low

Substrate:

CD28 (Involved in T cell activation)

Seq-ID:

P10747 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
identical protein binding, SH3/SH2 adaptor activity, coreceptor activity	external side of plasma membrane, cytosol, integral to plasma membrane	regulatory T cell differentiation, humoral immune response, positive regulation of anti-apoptosis, regulation of defense response to virus by virus, positive regulation of interleukin-2 biosynthetic process, positive regulation of viral genome replication, cell surface receptor linked signaling pathway, cytokine biosynthetic process, positive regulation of mitosis, positive regulation of T cell proliferation, positive regulation of translation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	191	SKRSRLLHSDYMNMTPRRPGP	Lck	8992971	LTP	0.95		GRAP2 SH2; GRB2 SH2; ITK SH2; PIK3R1 SH2	-	0.44	-	medium

Substrate:

CD31 (Adhesion molecule)

Seq-ID:

Q08481 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	smooth muscle contractile fiber, cell junction, integral to membrane, soluble fraction, membrane raft	regulation of cell migration, Rho protein signal transduction, cell adhesion, wound healing

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	679	NKDPQNMDVEYTEVEVSSLEP	Lck	9624175	LTP	1.00		-	-	0.60	-	medium

Substrate:

CD33 (CD antigen)

Seq-ID:

P20138 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sugar binding, receptor activity	integral to plasma membrane	negative regulation of cell proliferation, cell-cell signaling, cell adhesion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	340	PTVEMDEELHYASLNFHGMNP	Lck	10887109	LTP	1.00		PTPN11 SH2; PTPN6 SH2	-	0.54	-	low

Substrate:

CD5 (T-cell surface glycoprotein CD5 precursor (Lymphocyte glycoprotein T1/Leu-1) (Lymphocyte antigen CD5))

Seq-ID:

P06127 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
scavenger receptor activity	integral to plasma membrane	cell recognition, cell proliferation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	453	NPTASHVDNEYSQPPRNSRLS	Lck	11298344	LTP	1.00		Lck SH2; RASA_group SH2	-	0.71	-	medium
Y	487	MQPDNSSDSDYDLHGAQRL	Lck	11298344	LTP	1.00		Lck SH2	-	0.70	-	medium

Substrate:

CTLA-4 (CD152 antigen)

Seq-ID:

P09793 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
	external side of plasma membrane, integral to membrane	immune response

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	201	KKRSPLTTGVYVKMPPTEPEC	Lck	9973379	LTP	1.00		-	-	0.36	-	low
Y	218	EPECEKQFQPYFIPIN	Lck	9973379	LTP	1.00		-	-	0.13	-	low

Substrate:

DAPP1 (Adapter molecule)

Seq-ID:

Q9UN19 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-74510 ERBB3_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphatidylinositol-3,4-bisphosphate binding, phosphatidylinositol-3,4,5-trisphosphate binding, protein tyrosine phosphatase activity, protein binding	plasma membrane, cytoplasm	protein amino acid dephosphorylation, signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	139	YPRKVEEPSIYESVRVHTAMQ	Lck	10880360	LTP	1.00		-	-	0.40	-	low

Substrate:

Erzin (Connection of cytoscheletro structure to plasma membrane)

Seq-ID:

P15311 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-73250   TB10A_HUMAN
MINT-73254   PLCB3_HUMAN
MINT-73256   NHRF1_HUMAN
MINT-3318887   1433Z_HUMAN
MINT-6380786   FES_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
cell adhesion molecule binding, actin filament binding	filopodium, cortical cytoskeleton, actin filament, cytosol, ruffle membrane, microvillus membrane, extrinsic to membrane, apical plasma membrane	membrane to membrane docking, regulation of cell shape, actin filament bundle assembly, cytoskeletal anchoring at plasma membrane, leukocyte cell-cell adhesion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	146	DYNKEVHKSGYLSSERLIPQR	Lck	12560083	LTP	0.76		-	B41	0.26	1NI2	9.61%

Substrate:

Estrogen receptor alpha (Estrogen receptor (ER) (Estradiol receptor) (ER-alpha); nuclear hormone receptor. )

Seq-ID:

P03372 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-13786   BRCA1_HUMAN
MINT-50646   STA5A_HUMAN
MINT-50709   M3K1_HUMAN
MINT-5222241   NCOA1_HUMAN
MINT-6169667   EGFR_HUMAN
MINT-6614126   SMCA4_HUMAN
MINT-6614301   CHD3_HUMAN
MINT-6614361   MTA1_HUMAN
MINT-6614421   MTA2_HUMAN
MINT-6761899   PTN1_HUMAN
MINT-6761906   PTN6_HUMAN
MINT-7013584   PA1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
beta-catenin binding, nitric-oxide synthase regulator activity, estrogen response element binding, steroid binding, zinc ion binding, sequence-specific DNA binding transcription factor activity, estrogen receptor activity	chromatin remodeling complex	response to estradiol stimulus, transcription, DNA-dependent, regulation of transcription, DNA-dependent, positive regulation of retinoic acid receptor signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	537	SMKCKNVVPLYDLLLEMLDAH	Lck	7539106	LTP	0.96		Src SH2	Hormone_recep	0.06	2IOG	27.07%

Substrate:

IKB-alpha (Major histocompatibility complex enhancer-binding protein MAD3)

Seq-ID:

P25963 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-47837   REL_HUMAN
MINT-47839   IKBB_HUMAN
MINT-47840   ELP1_HUMAN
MINT-47841   IKKA_HUMAN
MINT-47842   IKKB_HUMAN
MINT-47843   NEMO_HUMAN
MINT-47845   MCM7_HUMAN
MINT-48656   NFKB1_HUMAN
MINT-48721   NFKB2_HUMAN
MINT-48993   RELB_HUMAN
MINT-64895   MED19_HUMAN
MINT-6762163   PTN1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
nuclear localization sequence binding, identical protein binding, ubiquitin protein ligase binding, NF-kappaB binding	cytosol, I-kappaB/NF-kappaB complex, nucleus	positive regulation of gene-specific transcription from RNA polymerase II promoter, cytoplasmic sequestering of NF-kappaB, negative regulation of NF-kappaB transcription factor activity, apoptosis, anti-apoptosis, negative regulation of lipid storage, negative regulation of macrophage derived foam cell differentiation, positive regulation of cholesterol efflux, interspecies interaction between organisms, positive regulation of cellular protein metabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	42	SGLDSMKDEEYEQMVKELQEI	Lck	8797825	LTP	1.00		PIK3R1 SH2	-	0.55	-	-

Substrate:

IL-2R beta (Cytokin receptor)

Seq-ID:

P14784 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
interleukin-2 receptor activity	external side of plasma membrane, integral to plasma membrane	protein complex assembly, positive regulation of survival gene product expression, interspecies interaction between organisms

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	381	DALEIEACQVYFTYDPYSEED	Lck	10214954	LTP	1.00	-	-	0.40	-	medium
Y	381	DALEIEACQVYFTYDPYSEED	Lck	2047859	LTP	1.00	-	-	0.40	-	medium
Y	384	EIEACQVYFTYDPYSEEDPDE	Lck	10214954	LTP	1.00	-	-	0.46	-	medium
Y	384	EIEACQVYFTYDPYSEEDPDE	Lck	2047859	LTP	1.00	-	-	0.46	-	medium
Y	387	ACQVYFTYDPYSEEDPDEGVA	Lck	10214954	LTP	0.00	-	-	0.53	-	medium
Y	387	ACQVYFTYDPYSEEDPDEGVA	Lck	2047859	LTP	0.00	-	-	0.53	-	medium
Y	418	LQPLSGEDDAYCTFPSRDDLL	Lck	10214954	LTP	1.00	SHB SH2; STAT5 SH2	-	0.55	-	medium
Y	536	NARLPLNTDAYLSLQELQGQD	Lck	10214954	LTP	1.00	SHB SH2; STAT5 SH2	-	0.71	-	medium

Substrate:

ITK (Tyrosine kinase)

Seq-ID:

Q08881 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-59473   LCP2_HUMAN
MINT-61278   G3BP1_HUMAN
MINT-74558   ERBB2_HUMAN
MINT-74559   ERBB3_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
metal ion binding, non-membrane spanning protein tyrosine kinase activity, ATP binding, protein binding	plasma membrane, cytosol	protein amino acid phosphorylation, signal transduction, cellular defense response

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	512	GMTRFVLDDQYTSSTGTKFPV	Lck	9312162	LTP	1.00		-	TyrKc	0.15	-	-
Y	512	GMTRFVLDDQYTSSTGTKFPV	Lck	12842872	LTP	1.00		-	TyrKc	0.15	-	-

Substrate:

LAMP (Unclassified)

Seq-ID:

Q91GT2 [Human herpesvirus 8]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	480	QAATQPTDDLYEEVLFPRN	Lck	12915550	LTP	-		-	Herpes_LAMP2	0.68	-	low

Substrate:

LCK (proto-oncogene tyrosine-protein kinase Lck (from PhosphoBase))

Seq-ID:

P06239 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-15516   CBL_HUMAN
MINT-56730   KSYK_HUMAN
MINT-59474   LCP2_HUMAN
MINT-59476   ZAP70_HUMAN
MINT-60779   MK01_HUMAN
MINT-60782   CD3Z_HUMAN
MINT-61276   G3BP1_HUMAN
MINT-66002   CD4_HUMAN
MINT-66003   P85A_HUMAN
MINT-68489   DLG1_HUMAN
MINT-3373863   HS90A_HUMAN
MINT-3373920   GCR_HUMAN
MINT-7135817   SH22A_HUMAN
MINT-7212471   KHDR1_HUMAN
MINT-7212499   WASP_HUMAN
MINT-7218109   ADA15_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphoinositide 3-kinase binding, protein C-terminus binding, protein kinase binding, protein serine/threonine phosphatase activity, glycoprotein binding, non-membrane spanning protein tyrosine kinase activity, ATP binding, CD8 receptor binding, ATPase binding, CD4 receptor binding, SH2 domain binding	plasma membrane, cytosol, Golgi apparatus, membrane raft, pericentriolar material	protein amino acid phosphorylation, T cell differentiation, response to drug, activation of caspase activity, positive regulation of T cell activation, positive regulation of T cell receptor signaling pathway, release of sequestered calcium ion into cytosol, interspecies interaction between organisms, cellular zinc ion homeostasis, induction of apoptosis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	394	GLARLIEDNEYTAREGAKFPI	Lck	3265417	LTP	0.84		Csk SH2	TyrKc	0.18	3LCK	54.59%
Y	505	EDFFTATEGQYQPQP	Lck	8945479	LTP	0.96		Lck SH2; Src SH2; SYK SH2	-	0.49	-	-

Substrate:

LNK (Adapter molecule)

Seq-ID:

Q9UQQ2 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-74566   EGFR_HUMAN
MINT-74567   ERBB2_HUMAN
MINT-74569   ERBB3_HUMAN

GO-Terms:

Molecular Function	Cellular Component	Biological Process
signal transducer activity

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	273	CTRLEMPDNLYTFVLKVKDRT	Lck	9169414	LTP	0.03		-	PH	0.22	-	medium

Substrate:

PKC delta (Protein kinase C, delta)

Seq-ID:

P28867 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein kinase C activity, metal ion binding, insulin receptor substrate binding, ATP binding	cytoplasm, membrane	protein amino acid phosphorylation, negative regulation of insulin receptor signaling pathway, negative regulation of peptidyl-tyrosine phosphorylation, interleukin-10 production, B cell proliferation, immunoglobulin mediated immune response, interleukin-12 production

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	311	KLDTTESVGIYQGFEKKPEVS	Lck	11381116	LTP	0.16		-	-	0.33	-	low

Substrate:

PKC theta (Serine/threonine kinase)

Seq-ID:

Q04759 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-4787821 MARK3_HUMAN
MINT-4787847 MALT1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein kinase C activity, metal ion binding, ATP binding, protein binding		intracellular signaling pathway, protein amino acid phosphorylation, regulation of cell growth, membrane protein ectodomain proteolysis

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	90	DLISETTVELYSLAERCRKNN	Lck	10652356	LTP	0.00		-	-	0.23	-	-

Substrate:

PLC gamma 2 (Involved in transmembrane signaling)

Seq-ID:

P16885 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-60791   Z512B_HUMAN
MINT-74685   EGFR_HUMAN
MINT-74686   ERBB2_HUMAN
MINT-7252126   P85A_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
phosphoinositide phospholipase C activity, signal transducer activity, protein binding	plasma membrane	phospholipid catabolic process

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	743	YPVTPELLERYNMERDINSLY	Lck	12181444	LTP	0.05	-	-	0.27	-	medium
Y	753	YNMERDINSLYDVSRMYVDPS	Lck	11606584	LTP	0.37	PLCG2 SH2	-	0.26	-	medium
Y	753	YNMERDINSLYDVSRMYVDPS	Lck	12181444	LTP	0.37	PLCG2 SH2	-	0.26	-	medium
Y	759	INSLYDVSRMYVDPSEINPSM	Lck	11606584	LTP	0.98	PLCG2 SH2	-	0.33	-	medium
Y	759	INSLYDVSRMYVDPSEINPSM	Lck	12181444	LTP	0.98	PLCG2 SH2	-	0.33	-	medium
Y	1197	RPVLESEEELYSSCRQLRRRQ	Lck	15184383	LTP	1.00	-	-	0.33	-	medium
Y	1217	QEELNNQLFLYDTHQNLRNAN	Lck	15184383	LTP	1.00	-	-	0.35	-	medium

Substrate:

PTEN (Lipid phosphatase)

Seq-ID:

P60484 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-63918   SCG1_HUMAN
MINT-63919   HBA_HUMAN
MINT-63921   UT14A_HUMAN
MINT-2832448   NHRF1_HUMAN
MINT-2832646   NHRF2_HUMAN
MINT-2832742   NHRF2_MOUSE
MINT-2832984   PGFRB_HUMAN
MINT-6793823   CAV1_HUMAN
MINT-7266561   PRDX1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
magnesium ion binding, phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity, protein tyrosine phosphatase activity, phosphatidylinositol-3-phosphatase activity, lipid binding, protein serine/threonine phosphatase activity, protein tyrosine/serine/threonine phosphatase activity, phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity, enzyme binding, inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity, PDZ domain binding	cytosol, nucleus	protein stabilization, inositol phosphate dephosphorylation, central nervous system development, regulation of cyclin-dependent protein kinase activity, regulation of neuron projection development, apoptosis, positive regulation of transcription factor activity, protein amino acid dephosphorylation, canonical Wnt receptor signaling pathway, phosphoinositide dephosphorylation, negative regulation of cell migration, induction of apoptosis, negative regulation of focal adhesion assembly, negative regulation of protein kinase B signaling cascade, cell proliferation, negative regulation of protein amino acid phosphorylation

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	240	GPTRREDKFMYFEFPQPLPVC	Lck	11948419	LTP	0.46		-	PTEN_C2	0.22	1D5R	10.48%
Y	315	SIERADNDKEYLVLTLTKNDL	Lck	11948419	LTP	0.11		-	PTEN_C2	0.38	1D5R	27.95%

Substrate:

SIGLEC10 (cell adhesion molecule)

Seq-ID:

Q96LC7 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
sugar binding	plasma membrane, extracellular region, integral to membrane	cell adhesion

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	597	RFSRHSTILDYINVVPTAGPL	Lck	11733002	LTP	0.17	-	-	0.39	-	low
Y	667	ESQESQEELHYATLNFPGVRP	Lck	11733002	LTP	1.00	PTPN6 SH2	-	0.78	-	low
Y	691	ARMPKGTQADYAEVKFQ	Lck	11733002	LTP	1.00	-	-	0.74	-	low

Substrate:

SLP-76 (Adaptor molecule; involved in T cell AG receptor mediate signaling)

Seq-ID:

Q13094 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-15244   FYB_HUMAN
MINT-16513   SHC1_HUMAN
MINT-16846   CBL_HUMAN
MINT-17488   FCGR1_HUMAN
MINT-59471   ITK_MOUSE
MINT-59473   ITK_HUMAN
MINT-59474   LCK_HUMAN
MINT-2837400   PLCG1_BOVIN
MINT-4302560   STAM1_HUMAN
MINT-4302608   STAM2_HUMAN
MINT-7041321   GRAP2_HUMAN
MINT-7306527   NCK1_HUMAN
MINT-7306585   SRC_CHICK
MINT-7306598   SRC_HUMAN
MINT-7306611   FYN_HUMAN
MINT-7306624   P85A_HUMAN
MINT-7306637   PLCG1_HUMAN
MINT-7306657   GRB2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein binding	cytosol	immune response, transmembrane receptor protein tyrosine kinase signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	113	GGWSSFEEDDYESPNDDQDGE	Lck	8702662	LTP	0.99		ITK SH2; NCK SH2; PIK3R1 SH2; PTPN6 SH2; VAV1 SH2; VAV_group SH2	-	0.92	-	medium
Y	128	DDQDGEDDGDYESPNEEEEAP	Lck	8702662	LTP	0.30		ITK SH2; NCK SH2; PIK3R1 SH2; PTPN6 SH2; VAV1 SH2; VAV_group SH2	-	0.98	-	medium

Substrate:

SOCS3 (protein kinase inhibitor activity)

Seq-ID:

O14543 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

MINT-63063 PIN1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein kinase inhibitor activity		regulation of growth, negative regulation of signal transduction, anti-apoptosis, JAK-STAT cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	204	RKTVNGHLDSYEKVTQLPGPI	Lck	12783885	LTP	0.19		-	SOCS_box	0.51	-	-
Y	221	PGPIREFLDQYDAPL	Lck	15173187	LTP	0.99		CRKL SH2; NCK SH2; RASA_group SH2	SOCS_box	0.43	-	-

Substrate:

Spectrin (Cytoskeletal protein)

Seq-ID:

Q13813 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-19442   FANCA_HUMAN
MINT-48101   IKKE_HUMAN
MINT-48416   M3K3_HUMAN
MINT-49194   TAB2_HUMAN
MINT-64161   TSSC4_HUMAN
MINT-65417   DDX24_HUMAN
MINT-72663   HS90B_HUMAN
MINT-2985122   ZO1_HUMAN
MINT-3318904   1433Z_HUMAN
MINT-7211761   EVL_HUMAN
MINT-7231852   FANCG_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
calcium ion binding, structural constituent of cytoskeleton, actin binding, calmodulin binding	membrane fraction, microtubule cytoskeleton, cytosol, spectrin	actin filament capping

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	1176	EVQAVQQQEVYGMMPRDETDS	Lck	11971983	LTP	0.00		-	SPEC	0.63	-	medium

Substrate:

Tyrosine-protein phosphatase, non-receptor type 6 (Protein tyrosine phosphatase containing SH2 domains)

Seq-ID:

P29350 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-56658   TFG_HUMAN
MINT-73504   EPOR_HUMAN
MINT-74919   FCG2B_HUMAN
MINT-6761906   ESR1_HUMAN
MINT-6793815   CAV1_HUMAN
MINT-6799844   ROS_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
protein tyrosine phosphatase activity, protein binding	cytosol, nucleus, membrane	apoptosis, protein amino acid dephosphorylation, signal transduction, G-protein coupled receptor protein signaling pathway

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	536	LQSQKGQESEYGNITYPPAMK	Lck	8114715	LTP	1.00	Lck SH2; Src SH2	-	0.56	-	low
Y	564	RTSSKHKEDVYENLHTKNKRE	Lck	8114715	LTP	0.31	PIK3R1 SH2; SH3BP2 SH2	-	0.72	-	low
Y	564	RTSSKHKEDVYENLHTKNKRE	Lck	10488096	LTP	0.31	PIK3R1 SH2; SH3BP2 SH2	-	0.72	-	low

Substrate:

Vav (Adaptor molecule. GDP/GTP exchange factor in Rho/Rac molecule)

Seq-ID:

P15498 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-17467   CRK_HUMAN
MINT-2837376   PLCG1_BOVIN
MINT-4549720   3BP2_HUMAN
MINT-6743318   RAC1_HUMAN
MINT-6743347   RHOA_HUMAN
MINT-6743356   CDC42_HUMAN
MINT-7226634   ITB2_HUMAN
MINT-7226674   ABL1_HUMAN
MINT-7300569   KHDR1_MOUSE
MINT-7300587   KHDR1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
Rho guanyl-nucleotide exchange factor activity, metal ion binding, sequence-specific DNA binding transcription factor activity, protein binding	plasma membrane, cytosol	induction of apoptosis by extracellular signals, apoptosis, regulation of Rho protein signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	ELM	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	142	EEESVGDEDIYSGLSDQIDDT	Lck	16285729	LTP	1.00		Lck SH2	-	0.49	-	medium
Y	160	DDTVEEDEDLYDCVENEEAEG	Lck	16285729	LTP	1.00		-	-	0.51	-	medium

Substrate:

Vav (Adaptor molecule. GDP/GTP exchange factor in Rho/Rac molecule)

Seq-ID:

P27870 [Mus musculus]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-18284 HNRPK_MOUSE
MINT-7300603 KHDR1_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
Rho guanyl-nucleotide exchange factor activity, metal ion binding	intracellular	regulation of Rho protein signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	142	EDSALNDEDIYSGLSDQIDDT	Lck	10669745	LTP	1.00	-	-	0.46	-	-
Y	160	DDTAEEDEDLYDCVENEEAEG	Lck	10669745	LTP	1.00	-	-	0.56	-	-
Y	174	ENEEAEGDEIYEDLMRLESVP	Lck	10669745	LTP	1.00	-	-	0.49	-	-

Substrate:

Vav 2 (Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases)

Seq-ID:

P52735 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-74802   ERBB2_HUMAN
MINT-74803   ERBB3_HUMAN
MINT-7301276   3BP2_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
Rho guanyl-nucleotide exchange factor activity, metal ion binding	cytosol	induction of apoptosis by extracellular signals, angiogenesis, apoptosis, regulation of Rho protein signal transduction

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	142	EETTENDDDVYRSLEELADEH	Lck	12454019	LTP	1.00	-	-	0.54	-	low
Y	159	ADEHDLGEDIYDCVPCEDGGD	Lck	12454019	LTP	0.04	-	-	0.31	-	low
Y	172	VPCEDGGDDIYEDIIKVEVQQ	Lck	12454019	LTP	1.00	-	-	0.25	-	low

Substrate:

ZAP70 (Cytoplasmic tyrosine kinase)

Seq-ID:

P43403 [Homo sapiens]

Download:

fasta csv

Interaction Network(s):

External Source(s):

MINT Interaction(s):

[show]

MINT-59476   LCK_HUMAN
MINT-60980   SHC1_HUMAN
MINT-74806   ERBB3_HUMAN
MINT-74807   EGFR_HUMAN
MINT-3374106   HS90A_HUMAN
MINT-3382488   LAT_HUMAN

GO-Terms:

[show]

Molecular Function	Cellular Component	Biological Process
non-membrane spanning protein tyrosine kinase activity, ATP binding	cytosol, T cell receptor complex	positive thymic T cell selection, immune response, intracellular protein kinase cascade

Conservation:

Click on table headers for sorting

Res.	Pos.	Sequence	Kinase	PMID	Src	Cons.	Binding Domain	SMART/Pfam	IUPRED score	PDB	P3D Acc.
Y	292	RRIDTLNSDGYTPEPARITSP	Lck	8756661	LTP	1.00	CBL PTB; CBL SH2; CRKL SH2	-	0.65	-	-
Y	292	RRIDTLNSDGYTPEPARITSP	Lck	7961936	LTP	1.00	CBL PTB; CBL SH2; CRKL SH2	-	0.65	-	-
Y	474	ARNVLLVNRHYAKISDFGLSK	Lck	9685404	LTP	1.00	SHC_group SH2	TyrKc	0.07	1U59	13.97%
Y	492	LSKALGADDSYYTARSAGKWP	Lck	8756661	LTP	1.00	Fyn SH2	TyrKc	0.14	1U59	13.10%
Y	492	LSKALGADDSYYTARSAGKWP	Lck	7961936	LTP	1.00	Fyn SH2	TyrKc	0.14	1U59	13.10%
Y	492	LSKALGADDSYYTARSAGKWP	Lck	7642520	LTP	1.00	Fyn SH2	TyrKc	0.14	1U59	13.10%
Y	492	LSKALGADDSYYTARSAGKWP	Lck	11270871	LTP	1.00	Fyn SH2	TyrKc	0.14	1U59	13.10%
Y	493	SKALGADDSYYTARSAGKWPL	Lck	8756661	LTP	1.00	Fyn SH2	TyrKc	0.13	1U59	68.12%
Y	493	SKALGADDSYYTARSAGKWPL	Lck	7961936	LTP	1.00	Fyn SH2	TyrKc	0.13	1U59	68.12%
Y	493	SKALGADDSYYTARSAGKWPL	Lck	7642520	LTP	1.00	Fyn SH2	TyrKc	0.13	1U59	68.12%
Y	493	SKALGADDSYYTARSAGKWPL	Lck	11270871	LTP	1.00	Fyn SH2	TyrKc	0.13	1U59	68.12%